BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827690   7 SVFAYESSVHSTNVLLSLNDQRKKDVLCDVTIFVEGQRFRAHRSVLAACSSYFHSRIVGQADGELNITLPEEVTVKGFEP 86
Cdd:cd18277   1 SVFAYESSVHSTNVLLSLNDQRKKDVLCDVTILVEGQRFRAHRSVLAACSSYFHSRIVGQADAELNITLPEEVTVKGFEP 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 45827690  87 LIQFAYTAKLILSKENVDEVCKCVEFLSVHNIEESCFQFL 126
Cdd:cd18277  81 LIQFAYTAKLILSKDNVDEVCKCVEFLSVHNIEESCFQFL 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827690   7 SVFAYESSVHSTNVLLSLNDQRKKDVLCDVTIFVEGQRFRAHRSVLAACSSYFHSRIVGQADGELNITLPEEVTVKGFEP 86
Cdd:cd18277   1 SVFAYESSVHSTNVLLSLNDQRKKDVLCDVTILVEGQRFRAHRSVLAACSSYFHSRIVGQADAELNITLPEEVTVKGFEP 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 45827690  87 LIQFAYTAKLILSKENVDEVCKCVEFLSVHNIEESCFQFL 126
Cdd:cd18277  81 LIQFAYTAKLILSKDNVDEVCKCVEFLSVHNIEESCFQFL 120

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827690    24 LNDQRKKDVLCDVTIFVEGQRFRAHRSVLAACSSYFHSRIVGQADGELNITLP-EEVTVKGFEPLIQFAYTAKLIlSKEN 102
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITlDDVSPEDFEALLEFMYTGKLI-SEEN 79

                          90       100
                  ....*....|....*....|....*
gi 45827690   103 VDEVCKCVEFLSVHNIEESCFQFLK 127
Cdd:pfam00651  80 VDDLLAAADKLQIPSLVDKCEEFLI 104

bZIP Maf transcription factor; Maf transcription factors contain a conserved basic region leucine zipper (bZIP) domain, which mediates their dimerization and DNA binding property. Thus, this family is probably related to pfam00170. This family also includes the DNA_binding domain of Skn-1, this domain lacks the leucine zipper found in other bZip domains, and binds DNA is a monomer.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 45827690   528 FNAQRIISLSRNDFQSLLKmhKLTPEQLDCIHDIRRRSKNRIAAQRCRKRKLDCIQNLESEIEKLQSEKESLLKERD 604
Cdd:pfam03131   1 LSDEELLSMSVREFNRFLR--GLTEEEVIRLKQRRRRLKNRGYAQSCRKRRLQQKESLEKERSELREQLERLVQELS 75

hypothetical protein; Provisional

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827690   11 YESSVHSTNVLLSLNDQRKKDVLCDVTIFV-EGQRFRAHRSVLAACSSYFHS-----RIVGQADGELNITLPEEVTVKGf 84
Cdd:PHA02713   3 IDDIKHNRRVVSNISNLLDDDILCDVIITIgDGEEIKAHKTILAAGSKYFRTlfttpMIIRDLVTRVNLQMFDKDAVKN- 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 45827690   85 epLIQFAYTAKliLSKENVDEVCKCVEFLSVHNIEESCFQFLK 127
Cdd:PHA02713  82 --IVQYLYNRH--ISSMNVIDVLKCADYLLIDDLVTDCESYIK 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827690   7 SVFAYESSVHSTNVLLSLNDQRKKDVLCDVTIFVEGQRFRAHRSVLAACSSYFHSRIVGQADGELNITLPEEVTVKGFEP 86
Cdd:cd18277   1 SVFAYESSVHSTNVLLSLNDQRKKDVLCDVTILVEGQRFRAHRSVLAACSSYFHSRIVGQADAELNITLPEEVTVKGFEP 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 45827690  87 LIQFAYTAKLILSKENVDEVCKCVEFLSVHNIEESCFQFL 126
Cdd:cd18277  81 LIQFAYTAKLILSKDNVDEVCKCVEFLSVHNIEESCFQFL 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827690   4 SENSVFAYESSVHSTNVLLSLNDQRKKDVLCDVTIFVEGQRFRAHRSVLAACSSYFHSRIVGQADGELNITLPEEVTVKG 83
Cdd:cd18278   2 TESPMYVYESTVHCTNILLCLNDQRKQDILCDVTLIVEGKEFRAHRAVLAACSEYFLQALVGQTENDLVVSLPEEVTARG 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 45827690  84 FEPLIQFAYTAKLILSKENVDEVCKCVEFLSVHNIEESCFQFL 126
Cdd:cd18278  82 FGPLLQFAYTAKLLLSRENIQEVIRCAEFLRMHNLEDSCFRFL 124

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827690  15 VHSTNVLLSLNDQRKKDVLCDVTIFVEGQRFRAHRSVLAACSSYFHSRIVGQADGELNITLPEE--------VTVKGFEP 86
Cdd:cd18228   1 SHSQELLGKLNSLRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFRSKLVGQASPRLVLVSPAGkcvldlhhVTVTGFAP 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 45827690  87 LIQFAYTAKLILSKENVDEVCKCVEFLSVHNIEESCFQFLK 127
Cdd:cd18228  81 LLEYAYTSTLSINTENIIDVLAAASYMQMFNVANTCSEFMK 121

Basic leucine zipper (bZIP) domain of Cap'n'Collar (CNC) transcription factors: a DNA-binding and dimerization domain; CNC proteins form a subfamily of Basic leucine zipper (bZIP) transcription factors that are defined by a conserved 43-amino acid region (called the CNC domain) located N-terminal to the bZIP DNA-binding domain. This subfamily includes Drosophila Cnc and four vertebrate counterparts, NFE2 (nuclear factor, erythroid-derived 2), NFE2-like 1 or NFE2-related factor 1 (NFE2L1 or Nrf1), NFE2L2 (or Nrf2), and NFE2L3 (or Nrf3). It also includes BACH1 and BACH2, which contain an additional BTB domain (Broad complex###Tramtrack###Bric-a-brac domain, also known as the POZ [poxvirus and zinc finger] domain). CNC proteins function during development and/or contribute in maintaining homeostasis during stress responses. In flies, Cnc functions both in development and in stress responses. In vertebrates, several CNC proteins encoded by distinct genes show varying functions and expression patterns. NFE2 is required for the proper development of platelets while the three Nrfs function in stress responses. Nrf2, the most extensively studied member of this subfamily, acts as a xenobiotic-activated receptor that regulates the adaptive response to oxidants and electrophiles. BACH1 forms heterodimers with small Mafs such as MafK to function as a repressor of heme oxygenase-1 (HO-1) gene (Hmox-1) enhancers. BACH2 is a B-cell specific transcription factor that plays a critical role in oxidative stress-mediated apoptosis. bZIP factors act in networks of homo and heterodimers in the regulation of a diverse set of cellular processes. The bZIP structural motif contains a basic region and a leucine zipper, composed of alpha helices with leucine residues 7 amino acids apart, which stabilize dimerization with a parallel leucine zipper domain. Dimerization of leucine zippers creates a pair of the adjacent basic regions that bind DNA and undergo conformational change. Dimerization occurs in a specific and predictable manner resulting in hundreds of dimers having unique effects on transcription.

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 45827690 554 QLDCIHDIRRRSKNRIAAQRCRKRKLDCIQNLESEIEKLQSEKESLLKERDHILSTLGETKQNLTGLC 621
Cdd:cd14698   1 QLQLIRDIRRRGKNKVAAQNCRKRKLDQISTLEDEVDELKEEKEKLLKERDELEAETREMKDKYSQLY 68

Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain; This subfamily is composed of NFE2 and NFE2-like proteins including NFE2-like 1 or NFE2-related factor 1 (NFE2L1 or Nrf1), NFE2L2 (or Nrf2), and NFE2L3 (or Nrf3). These are Cap'n'Collar (CNC) Basic leucine zipper (bZIP) transcription factors that are defined by a conserved 43-amino acid region (called the CNC domain) located N-terminal to the bZIP DNA-binding domain. NFE2 functions in development; it is required for the proper development of platelets. The three Nrfs function in stress responses. Nrf2, the most extensively studied member of this subfamily, acts as a xenobiotic-activated receptor that regulates the adaptive response to oxidants and electrophiles. As the master regulator of the antioxidant defense pathway, it plays roles in the biology of inflammation, obesity, and cancer. Nrf1 is an essential protein that binds to the antioxidant response element (ARE) and is also involved in regulating oxidative stress. In addition, it also regulates genes involved in cell and tissue differentiation, inflammation, and hepatocyte homeostasis. bZIP factors act in networks of homo and heterodimers in the regulation of a diverse set of cellular processes. The bZIP structural motif contains a basic region and a leucine zipper, composed of alpha helices with leucine residues 7 amino acids apart, which stabilize dimerization with a parallel leucine zipper domain. Dimerization of leucine zippers creates a pair of the adjacent basic regions that bind DNA and undergo conformational change. Dimerization occurs in a specific and predictable manner resulting in hundreds of dimers having unique effects on transcription.

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 45827690 554 QLDCIHDIRRRSKNRIAAQRCRKRKLDCIQNLESEIEKLQSEKESLLKERDHILSTLGETKQNLTGLC 621
Cdd:cd14720   1 QLALIRDIRRRGKNKVAAQNCRKRKLDNIVGLEDEVEQLQRQREKLLREKAENAKSLREMKQKLNDLY 68

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827690  16 HSTNVLLSLNDQRKKDVLCDVTIFVEGQRFRAHRSVLAACSSYFHSRIVGQADGELN-ITLPEEVTVKGFEPLIQFAYTA 94
Cdd:cd18215   2 HASDVLLNLNRLRSRDILTDVVLVVGREQFRAHKTVLMACSGLFYSIFTDQLKNNVSvINLDPEIEPEGFRILLDFMYTS 81

                        90       100       110
                ....*....|....*....|....*....|.
gi 45827690  95 KLILSKENVDEVCKCVEFLSVHNIEESCFQF 125
Cdd:cd18215  82 RLNLREGNIMAVMATAMYLQMEHVVDTCRKF 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827690  16 HSTNVLLSLNDQRKKDVLCDVTIFVEGQRFRAHRSVLAACSSYFHSRIV-GQADGELNITLPEEVTVKGFEPLIQFAYTA 94
Cdd:cd18326   8 HSSDILSSLNEQRTQGLLCDVVILVEGREFPTHRSVLAACSQYFKKLFTsGAVVDQQNVYEIDFVSAEALTALLDFAYTA 87

                        90       100       110
                ....*....|....*....|....*....|..
gi 45827690  95 KLILSKENVDEVCKCVEFLSVHNIEESCFQFL 126
Cdd:cd18326  88 TLTVSTSNVGDILSAARLLEIPAVSHVCADLL 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827690  16 HSTNVLLSLNDQRKKDVLCDVTIFVEGQRFRAHRSVLAACSSYFHSRIVGQAD-GELNITlpeevTVKGFEPLIQFAYTA 94
Cdd:cd18206   5 HSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFRMLFVDQKDvVHLDIS-----NAAGLGQVLEFMYTA 79

                        90       100       110
                ....*....|....*....|....*....|.
gi 45827690  95 KLILSKENVDEVCKCVEFLSVHNIEESCFQF 125
Cdd:cd18206  80 KLSLSPENVDDVLAVATFLQMQDIVTACHAL 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827690  16 HSTNVLLSLNDQRKKDVLCDVTIFVEGQRFRAHRSVLAACSSYFHSRI--VGQADGELNITLPEEVTVKGFEPLIQFAYT 93
Cdd:cd18230   4 HYRHLLRELNEQRQHGILCDVCIIVEGKIFKAHKNVLLGSSRYFKTLYcqVQKTSDQATVTHLDIVTAQGFKAIIDFMYS 83

                        90       100       110
                ....*....|....*....|....*....|....
gi 45827690  94 AKLILSKENVDEVCKCVEFLSVHNIEESCFQFLK 127
Cdd:cd18230  84 AHLALTSKNVIEVMSAASYLQMTDIVQACHNFIK 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827690  16 HSTNVLLSLNDQRKKDVLCDVTIFVEGQRFRAHRSVLAACSSYFHSRIVGQADG------ELNITLPEEVTVkgfepLIQ 89
Cdd:cd18198   8 HSSEILSGLNEQRTQGLLCDVVILVQGREYRTHRSVLAACSQYFKKLFTSGAVVdqqnvyEIDFVSPEALTA-----LLE 82

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 45827690  90 FAYTAKLILSKENVDEVCKCVEFLSVHNIEESCFQFLK 127
Cdd:cd18198  83 FAYTATLTVSTANVGDILSAARLLEIPCVSHVCAEILD 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827690  20 VLLSLNDQRKKDVLCDVTIFVEGQRFRAHRSVLAACSSYFHSRIV---GQADGELNITLPEEVTVKGFEPLIQFAYTAKL 96
Cdd:cd18201   8 LLQELNEQRKKGILCDVNIVVSGKVFRAHKNILVAGSRFFKTLYCftnKESCDQTTVTHLDVVAVQGFSVILDFMYSGNL 87

                        90       100       110
                ....*....|....*....|....*....|.
gi 45827690  97 ILSKENVDEVCKCVEFLSVHNIEESCFQFLK 127
Cdd:cd18201  88 VLTSQNAIEVMSVASYLQMTEVVQSCRNFIK 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827690  17 STNVLLSLNDQRKKDVLCDVTIFVEGQRFRAHRSVLAACSSYFHSRIVgqADGELNITLPEEVTVKGFEPLIQFAYTAKL 96
Cdd:cd18210   5 TSSLLESLNQQRMEGKLCDISIHVQGRVFRAHRAVLAASSPYFHDQVL--LKNMSSISLPGVMDPGAFESVLASAYTGKL 82

                        90       100       110
                ....*....|....*....|....*....|
gi 45827690  97 ILSKENVDEVCKCVEFLSVHNIEESCFQFL 126
Cdd:cd18210  83 TMLADEIVNYLTVGSVLQMWHIVDKCTELL 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827690  16 HSTNVLLSLNDQRKKDVLCDVTIFVEGQRFRAHRSVLAACSSYFHSRIVGQADG------ELNITLPEEVTVkgfepLIQ 89
Cdd:cd18328   8 HSSEVLCSLNEQRHDGLLCDVVLIVQDQEYRTHRSVLAACSKYFKKLFTAGTLAdqpyvyEIDFVTPEALSA-----ILE 82

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 45827690  90 FAYTAKLILSKENVDEVCKCVEFLSVHNIEESCFQFL 126
Cdd:cd18328  83 FAYTSTLTITTSNVKHILNAAQMLEIQCIINVCLEIM 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827690  16 HSTNVLLSLNDQRKKDVLCDVTIFVEGQRFRAHRSVLAACSSY----FHSRivGQADGELNITLpEEVTVKGFEPLIQFA 91
Cdd:cd18306   1 HPESVLAKLNALRKNRQFCDVILQVGGHEIPAHRAVLACASPYlfelFSSD--SDGESILTVKL-DGLDPDAVEVLVNYA 77

                        90       100       110
                ....*....|....*....|....*....|....*
gi 45827690  92 YTAKLILSKENVDEVCKCVEFLSVHNIEESCFQFL 126
Cdd:cd18306  78 YTSRLEVPADLVKSVYSAAKKLKMDRVKKACGDFL 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827690  13 SSVHSTNVLLSLNDQRKKDVLCDVTIFVEGQRFRAHRSVLAACSSYFHSRIVGQADGELNITLPEEVTVKGFEPLIQFAY 92
Cdd:cd18212   3 SKTHKDTVLTNFEEQRKKDFLCDITLIVENVQFRAHKALLAASSEYFSMMFADEGEVGQSIYMLEGMVAETFGALLEFIY 82

                        90       100
                ....*....|....*....|....*.
gi 45827690  93 TAKLILSKENVDEVCKCVEFLSVHNI 118
Cdd:cd18212  83 TGCLQVGEKSLEQILATAQFLKVNDL 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827690  14 SVHSTNVLlslNDQRKKDVLCDVTIFVEGQRFRAHRSVLAACSSYFHSRIVGQadgeLNITLPEEVTVKGFEP-----LI 88
Cdd:cd18240   1 SAMACNVF---NELRLEGKLCDVVIRVNGVEFPAHRNILCACSPYFRALFTNG----WNETEKKVYKIPGVSPemmelII 73

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 45827690  89 QFAYTAKLILSKENVDE-------------VCKCVEFLSVHNIEESC 122
Cdd:cd18240  74 EYAYTRTVPITAENVEEllpaadqfnimgiVKACCDFLEDQLCPENC 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827690   9 FAYESSVHSTNVLLSLNDQRKKD-VLCDVTIFVEGQRFRAHRSVLAACSSYFHSRIVGQ--ADGELNITLPEEVTVKGFE 85
Cdd:cd18207   2 YTYQVSQHSADMLHNLNQQRKSGgRFCDVLLRVGEESFPAHRAVLAACSEYFESVFSAQegDGGTPRELEMHTISSKVFG 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 45827690  86 PLIQFAYTAKLILSKENVDEVCKCVEFLSVHNIEESCFQFLK 127
Cdd:cd18207  82 DILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIDICQEVIK 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827690  18 TNVLLSLNDQRKKDVLCDVTIFVEGQRFRAHRSVLAACSSYFHSRIVG--QADGELNITLPEEVTVKGFEPLIQFAYTAK 95
Cdd:cd18330   3 TKLLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLIHyiQDSGRHSTASLDIVTSEAFSIILDFLYSGK 82

                        90       100
                ....*....|....*....|....*..
gi 45827690  96 LILSKENVDEVCKCVEFLSVHNIEESC 122
Cdd:cd18330  83 LDLCSENVIEVMSAASYLQMTDVVNFC 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827690  16 HSTNVLLSLNDQRKKDVLCDVTIFVEGQRFRAHRSVLAACSSYFHSRIVgqADGELNITlPEEVTVKGFEPLIQFAYTAK 95
Cdd:cd18334   4 HAKQLLLQLNQQRAKGFLCDVIIVVENALFRAHKNILAASSMYFKSLVL--HDNLINLD-TDMVNPTVFRQILDFIYTGK 80

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 45827690  96 LILS----KENVDEVCKCVEFLSVHNIEESCFQFLK 127
Cdd:cd18334  81 LLTSdqpgEQNFNALLTAASYLQLHDLAALCRKKLK 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827690  12 ESSVHSTNVLLSLNDQRKKDVLCDVTIFVEGQRFRAHRSVLAACSSYFHSR----IVGQADGELNItlpEEVTVKGFEPL 87
Cdd:cd18261   7 QSKSHKDAVLAALNQQRNDGILCDITLVAEEQKFHAHKAVLAACSDYFRAMfslcMVESEADEVNL---HGVTSLGLKQA 83

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 45827690  88 IQFAYTAKLILSKENVDEVCKCVEFLSVHNIEESCFQFL-----KFKFLD 132
Cdd:cd18261  84 LDFAYTGQILLEPGVIQDVLAAGSHLQLLELLSLCSHYLiqelnSFNYLD 133

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827690  13 SSVHSTNVLLSLNDQRKKDVLCDVTIFVEGQRFRAHRSVLAACSSYFHSRIVgqadGELNITLPEEVTVKGFEP-----L 87
Cdd:cd18242   1 TNSHAKSILNTMNSLRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFT----SEMSEKGKSEVELQGLTAstmeiL 76

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 45827690  88 IQFAYTAKLILSKENVDEVCKCVEFLSVHNIEESCFQFL 126
Cdd:cd18242  77 LDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFL 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827690  16 HSTNVLLSLNDQRKKDVLCDVTIFVEGQRFRAHRSVLAACSSYFHSRIVGQADGELNITLPEE-VTVKGFEPLIQFAYTA 94
Cdd:cd18324   6 HSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHLFYKDQLDKRDIVHLNSDiVTAPAFALLLEFMYEG 85

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 45827690  95 KLILSKENVDEVCKCVEFLSVHNIEESCFQFLKFKfldSTADQQECPRKK-CFSSHCQ 151
Cdd:cd18324  86 KLQFKDLPIEDVLAAASYLHMYDIVKVCKKKLKEK---ATTEADSTKKEEdASSCSDK 140

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827690  16 HSTNVLLSLNDQRKKDVLCDVTIFVEGQRFRAHRSVLAACSSYFHSRIVgqADGELNITlPEEVTVKGFEPLIQFAYTAK 95
Cdd:cd18216   3 HATQLLLQLNNQRTKGFLCDVIIVVENSLFRAHKNVLAASSGYFKSLVL--HDNLIHLD-QDMVSPTVFQQILDFIYTGK 79

                        90       100       110
                ....*....|....*....|....*....|....*
gi 45827690  96 LILSKE---NVDEVCKCVEFLSVHNIEESCFQFLK 127
Cdd:cd18216  80 LLDSLFeepNLSEVLAAANYLQLPDLAALCRSKLK 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827690  16 HSTNVLLSLNDQRKKDVLCDVTIFVEGQRFRAHRSVLAACSSYFHSRIVgqadGELNITLPEEVTVKGFEP-----LIQF 90
Cdd:cd18338   4 HMKKAFKVMNELRSQNLLCDVTIVAEDVEIAAHRVVLAACSPYFHAMFT----GEMSESRAKRVRIKEVDGwtlkmLIDY 79

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 45827690  91 AYTAKLILSKENVDEVCKCVEFLSVHNIEESCFQFL 126
Cdd:cd18338  80 VYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFL 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827690  16 HSTNVLLSLNDQRKKDVLCDVTIFVEGQRFRAHRSVLAACSSYFHSRIVGQADG-ELNITLPEEVTVKGFEPLIQFAYTA 94
Cdd:cd18323   6 HSRHLLQSLREQRHQGFLCDCTVLVGSTQFLAHRAVLASCSPFFHMFYKEQLDKrDLVCINNEIVTAPAFSLLLEFMYEG 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 45827690  95 KLILSKENVDEVCKCVEFLSVHNIEESCFQFLKFKFL---DST 134
Cdd:cd18323  86 RLSFNDTPVEDVLAAASYLHMNDIVKVCKKRLQARALaeaDST 128