|
Name |
Accession |
Description |
Interval |
E-value |
| LamGL |
smart00560 |
LamG-like jellyroll fold domain; |
146-283 |
3.56e-36 |
|
LamG-like jellyroll fold domain;
:
Pssm-ID: 214722 [Multi-domain] Cd Length: 133 Bit Score: 135.24 E-value: 3.56e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 146 ASFTLAVWLKPEQQGVMCVIEKtvdGQIVFKLTISEKETMFYYRTV--NGLQPPIKVMTLGRIlvKKWIHLSVQVHQ--T 221
Cdd:smart00560 1 GSFTLEAWVKLESAGGSQPIIT---GAAVAQPTISEKALTFFLRAKsvQGWQTARTGATADWI--GVWVHLAGVYDGgaG 75
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1796365450 222 KISFFINGVEKDHTPFnarTLSGSITDFASGTvQIGQSLNGLEQFVGRMQDFRLYQVALTNR 283
Cdd:smart00560 76 KLSLYVNGVEVATSET---QPSPSSGNLPQGG-RILLGGAGGENFSGRLDEVRVYNRALTAR 133
|
|
| Laminin_N super family |
cl02806 |
Laminin N-terminal (Domain VI); |
291-516 |
1.99e-29 |
|
Laminin N-terminal (Domain VI);
The actual alignment was detected with superfamily member pfam00055:
Pssm-ID: 470680 Cd Length: 230 Bit Score: 119.61 E-value: 1.99e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 291 GDLL---RLHAQSHCrcpGSHPRvhplaQRYCIPNDAG-----DTADNRVSRLnpeAHPLSFV---NDNDVGTSWVSNvf 359
Cdd:pfam00055 6 GNLAfgrEVSATSTC---GLNGP-----ERYCILSGLEggkkcFICDSRDPHN---SHPPSNLtdsNNGTNETWWQSE-- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 360 TNITQLNQgVTISVDLEnGQYQVFYIIIQFFSPQPTEIRIQRKKENSLDWEDWQYFARNC-GAFGMKNNGDLE-KPDSVN 437
Cdd:pfam00055 73 TGVIQYEN-VNLTLDLG-KEFHFTYLILKFKSPRPAAMVLERSTDFGKTWQPYQYFASDCrRTFGRPSGPSRGiKDDEVI 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 438 CLQL-SNFTPYSRGNVTFSILtpgpNYRPGYNNFYNTPSLQEFVKATQIRFHFH-----GQYYTTETAVNLRHrYYAVDE 511
Cdd:pfam00055 151 CTSEySDISPLTGGEVIFSTL----EGRPSANIFDYSPELQDWLTATNIRIRLLrlhtlGDELLDDPSVLRKY-YYAISD 225
|
....*
gi 1796365450 512 ITISG 516
Cdd:pfam00055 226 ISVGG 230
|
|
| LamG |
cd00110 |
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ... |
1716-1868 |
1.76e-25 |
|
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.
:
Pssm-ID: 238058 [Multi-domain] Cd Length: 151 Bit Score: 105.58 E-value: 1.76e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1716 GAQFLGAGFLELhPYMFHGGMNFEISFKFRTDQLNGLLLFVYNKDGPDFLAMELKSGILTFRLNTSLAFTQVDllLGLSY 1795
Cdd:cd00110 1 GVSFSGSSYVRL-PTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGSGSLVLS--SKTPL 77
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1796365450 1796 CNGKWNKVIIKKEGSFISASVNG--LMKHASESGDQPLVVNSPVYVGGIPQELLNSYQHlcLEQGFGGCMKDVKF 1868
Cdd:cd00110 78 NDGQWHSVSVERNGRSVTLSVDGerVVESGSPGGSALLNLDGPLYLGGLPEDLKSPGLP--VSPGFVGCIRDLKV 150
|
|
| LamG |
cd00110 |
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ... |
1519-1678 |
2.67e-25 |
|
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.
:
Pssm-ID: 238058 [Multi-domain] Cd Length: 151 Bit Score: 104.81 E-value: 2.67e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1519 GIRFIGNGYCKFPSSthPVNTDFTGIKASFRTKVPEGLIVFAASpGNQEEYFALQLKKGRLYFLFDPQGSPVEVTTTNdh 1598
Cdd:cd00110 1 GVSFSGSSYVRLPTL--PAPRTRLSISFSFRTTSPNGLLLYAGS-QNGGDFLALELEDGRLVLRYDLGSGSLVLSSKT-- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1599 gkQYSDGKWHEIIAIRHQAFGQITLDGIYTGSSAILNGSTVIGDNTGVFLGGLPRSYtilRKDPEIIQKGFVGCLKDVHF 1678
Cdd:cd00110 76 --PLNDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDL---KSPGLPVSPGFVGCIRDLKV 150
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
4342-4765 |
5.79e-18 |
|
Fibronectin type 3 domain [General function prediction only];
:
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 91.60 E-value: 5.79e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4342 STSKPTSITTLEAAPSEVSPPDLWAVSATQMNVCWSPPTVQNGKITKYLVRydnkeSLAGQGLCLLVSHLQPYSQYNFSL 4421
Cdd:COG3401 51 SPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSG-----SVGGATNTGLTSSDEVPSPAVGTA 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4422 VACTNGGCTASVSKSAWTMEALPENMDSPTLQVTGSESIEITWKPPRNPNGQIRSYelrrDGTIVYTGLETRYRDFTLTP 4501
Cdd:COG3401 126 TTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVA----TTSLTVTSTTLVDGGGDIEP 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4502 GVEYSYTVTASNSQG-GILSPLV---KDRTSPSAPSGMeppKLQARGPQEILVNWDPPvrTNGDIINYTLFIRElfERET 4577
Cdd:COG3401 202 GTTYYYRVAATDTGGeSAPSNEVsvtTPTTPPSAPTGL---TATADTPGSVTLSWDPV--TESDATGYRVYRSN--SGDG 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4578 KIIHINTTHNSfgmqSYIVNQLKPFHRYEIRIQACTTLGCAS--SDWTFIQTPEIAPlmQPPPHLEVQMAPGGfqpTVSL 4655
Cdd:COG3401 275 PFTKVATVTTT----SYTDTGLTNGTTYYYRVTAVDAAGNESapSNVVSVTTDLTPP--AAPSGLTATAVGSS---SITL 345
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4656 LWTGPlqPNGKVLYYELYRrqiATQPRKSNPVLIYNGSSTSFIDSELLPFTEYEYQVWAVNSAGK--APS------SWTW 4727
Cdd:COG3401 346 SWTAS--SDADVTGYNVYR---STSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNesAPSeevsatTASA 420
|
410 420 430
....*....|....*....|....*....|....*...
gi 1796365450 4728 CRTGPAPPEGLRAPTFHVISSTQAVVNISAPGKPNGIV 4765
Cdd:COG3401 421 ASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVL 458
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
3450-3846 |
5.81e-17 |
|
Fibronectin type 3 domain [General function prediction only];
:
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 88.52 E-value: 5.81e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 3450 TIHTGSVNTYSYTDVNLKPYMTYEYRISAWNSYGRG-LSKAVRARTKEDVPqgvSPPTWTKIDNLEDTIV-LNWRKPiqS 3527
Cdd:COG3401 183 TSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESaPSNEVSVTTPTTPP---SAPTGLTATADTPGSVtLSWDPV--T 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 3528 NGPIIYYILLR--NGIERF----RGTSLSFSDKeGIQPFQEYSYQLKACTVAGC-ATSSKVVAATTQGVPesilPPSITA 3600
Cdd:COG3401 258 ESDATGYRVYRsnSGDGPFtkvaTVTTTSYTDT-GLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTP----PAAPSG 332
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 3601 LSAVA-----LHLSWSvpEKSNGVIKEYQI-RQVGKG----LIHTDTTDrRQHTVTGLQPYTNYSFTLTACTSAGCTS-- 3668
Cdd:COG3401 333 LTATAvgsssITLSWT--ASSDADVTGYNVyRSTSGGgtytKIAETVTT-TSYTDTGLTPGTTYYYKVTAVDAAGNESap 409
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 3669 SEPFLGQTLQAAP-----EGVWVTPRHIIINSTTVELYWSLPEKPNGLVSQYQLSRNGNLLFLGGSEEQNFTDKNLEPNS 3743
Cdd:COG3401 410 SEEVSATTASAASgesltASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANL 489
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 3744 RYTYKLEVKTGGGSSASDDYIVQTPMSTPEEIYPPYNITVIGPYSI-FVAWIPPGILIPEIPVEYNVLLNDGSVTPLAFS 3822
Cdd:COG3401 490 SVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASPvTVGASTGDVLITDLVSLTTSASSSVSGAGLGSG 569
|
410 420
....*....|....*....|....*.
gi 1796365450 3823 VGHHQSTLLENLTP--FTQYEIRIQA 3846
Cdd:COG3401 570 NLYLITTLGGSLLTttSTNTNDVAGV 595
|
|
| FN3 super family |
cl27307 |
Fibronectin type 3 domain [General function prediction only]; |
2685-3074 |
1.13e-14 |
|
Fibronectin type 3 domain [General function prediction only];
The actual alignment was detected with superfamily member COG3401:
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 81.20 E-value: 1.13e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2685 DKTSALSPWTKYEYRVLMSTLHGGTNSSAWVEVT---TRPSRPAGVQppvVTVLEPDAVQVTWKPPliQNGDILSYEIH- 2760
Cdd:COG3401 194 DGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTtptTPPSAPTGLT---ATADTPGSVTLSWDPV--TESDATGYRVYr 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2761 --MPDPH---ITLTNVTSAVlsqkVTHLIPFTNYSVTIVAcSGGNGYLGGCTESLptYVTTHPTVPQNVGPLSVIPLSES 2835
Cdd:COG3401 269 snSGDGPftkVATVTTTSYT----DTGLTNGTTYYYRVTA-VDAAGNESAPSNVV--SVTTDLTPPAAPSGLTATAVGSS 341
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2836 YVVISWQPPSkpnGPNL-RYELLRRKIqqplASNPPEDLNRwhnIYSGTQwlYEDKGLSRFTTYEYMLFVHNSVGFT--P 2912
Cdd:COG3401 342 SITLSWTASS---DADVtGYNVYRSTS----GGGTYTKIAE---TVTTTS--YTDTGLTPGTTYYYKVTAVDAAGNEsaP 409
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2913 SREVTVTTLAGLPERGANLTASVLNHTAIDVRWAKPTVQDLQGEVEYYTLFWSSATSNDSLKILPDVNshvighLKPNTE 2992
Cdd:COG3401 410 SEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTV------TATTTD 483
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2993 YWIFISVFNGVHSINSAGLHATTCDGEPQGMLPPEVVIINSTAVRVIWTSP--SNPNGVVTEYSIYVNNKLYKTGMNVPG 3070
Cdd:COG3401 484 TTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASpvTVGASTGDVLITDLVSLTTSASSSVSG 563
|
....
gi 1796365450 3071 SFIL 3074
Cdd:COG3401 564 AGLG 567
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
900-948 |
3.35e-14 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
:
Pssm-ID: 238012 Cd Length: 50 Bit Score: 69.69 E-value: 3.35e-14
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 1796365450 900 CECDSLGTLPGTiCDPISGQCLCVPNRQGRRCNQCQPGFYISPGNATGC 948
Cdd:cd00055 2 CDCNGHGSLSGQ-CDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGGGC 49
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
641-691 |
9.85e-14 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
:
Pssm-ID: 395007 Cd Length: 49 Bit Score: 68.15 E-value: 9.85e-14
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 1796365450 641 CDCDTVGTRNGSilCDQIGGQCNCKRHVSGRQCNQCQNGFYNLQELDPDGC 691
Cdd:pfam00053 1 CDCNPHGSLSDT--CDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
950-1000 |
2.18e-13 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
:
Pssm-ID: 238012 Cd Length: 50 Bit Score: 67.38 E-value: 2.18e-13
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 1796365450 950 PCSCHTTGAVNHICNSLTGQCVCQDAsIAGQRCDQCKDHYFGFDPQTGRCQ 1000
Cdd:cd00055 1 PCDCNGHGSLSGQCDPGTGQCECKPN-TTGRRCDRCAPGYYGLPSQGGGCQ 50
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
747-795 |
3.79e-13 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
:
Pssm-ID: 395007 Cd Length: 49 Bit Score: 66.61 E-value: 3.79e-13
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 1796365450 747 CQCNLHGSVNKFCNPHSGQCECKKEAKGLQCDTCRENFYGLDVTNCKAC 795
Cdd:pfam00053 1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
2533-2619 |
1.87e-12 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
:
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 65.98 E-value: 1.87e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2533 PGPVVPPILLDVKSRMMLVTWQHPRKSNGVITHYNIYLH------GRLYLRTPGNVTNCTVMHLHPYTAYKFQVEACTSK 2606
Cdd:cd00063 1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYRekgsgdWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80
|
90
....*....|...
gi 1796365450 2607 GCSLSPESQTVWT 2619
Cdd:cd00063 81 GESPPSESVTVTT 93
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
847-897 |
3.56e-12 |
|
Laminin-type epidermal growth factor-like domai;
:
Pssm-ID: 214543 Cd Length: 46 Bit Score: 63.87 E-value: 3.56e-12
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 1796365450 847 CNCDKTGTINGSllCNKSTGQCPCKLGVTGLRCNQCEPHRYNltiDNFQHC 897
Cdd:smart00180 1 CDCDPGGSASGT--CDPDTGQCECKPNVTGRRCDRCAPGYYG---DGPPGC 46
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
794-844 |
4.17e-12 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
:
Pssm-ID: 238012 Cd Length: 50 Bit Score: 63.53 E-value: 4.17e-12
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 1796365450 794 ACDCDTAGSLPGTvCNAKTGQCICKPNVEGRQCNKCLEGnFYLRQNNSFLC 844
Cdd:cd00055 1 PCDCNGHGSLSGQ-CDPGTGQCECKPNTTGRRCDRCAPG-YYGLPSQGGGC 49
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
1242-1357 |
7.24e-12 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
:
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 64.44 E-value: 7.24e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1242 PPQRLsppKMQKISSTELHVEWSPPAELNGIIIRYELYMRRLRSTKETTSEESRvfqssgwlsphsfvesanenalkPPQ 1321
Cdd:cd00063 3 PPTNL---RVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTP-----------------------GSE 56
|
90 100 110
....*....|....*....|....*....|....*..
gi 1796365450 1322 TMTTITGLEPYTKYEFRVLAVNMAG-SVSSAWVSERT 1357
Cdd:cd00063 57 TSYTLTGLKPGTEYEFRVRAVNGGGeSPPSESVTVTT 93
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
3964-4057 |
7.98e-12 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
:
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 64.44 E-value: 7.98e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 3964 PPQDfpaPWAQATSAHSVLLNWTKPESPNGIISHYRVVYQERPDDptfnsPTVHAFTVKGTSHQAHLYGLEPFTTYRIGV 4043
Cdd:cd00063 3 PPTN---LRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSG-----DWKEVEVTPGSETSYTLTGLKPGTEYEFRV 74
|
90
....*....|....
gi 1796365450 4044 VAANHAGEilSPWT 4057
Cdd:cd00063 75 RAVNGGGE--SPPS 86
|
|
| FN3 super family |
cl27307 |
Fibronectin type 3 domain [General function prediction only]; |
1103-1469 |
8.12e-12 |
|
Fibronectin type 3 domain [General function prediction only];
The actual alignment was detected with superfamily member COG3401:
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 71.96 E-value: 8.12e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1103 YPYSIQYFLDTDLLPYTKYSYYIETTNVHGSTrsvAVTYKTKPGVPEGNLTLSYIIPIGSDSVTLTWTTLSNQSGPIEKY 1182
Cdd:COG3401 93 GLTTLTGSGSVGGATNTGLTSSDEVPSPAVGT---ATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVV 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1183 IlscAPLAGGQPCVSYEGHETSATIW-----NLVPFAKYDFSVQACTSGGC-LHSLPITVTTAQAPPQRLSPPKMQKISS 1256
Cdd:COG3401 170 V---SPDTSATAAVATTSLTVTSTTLvdgggDIEPGTTYYYRVAATDTGGEsAPSNEVSVTTPTTPPSAPTGLTATADTP 246
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1257 TELHVEWSPPAELNgiIIRYELYmrrlRSTKettseesrvfqssgwlSPHSFVESANENAlkppqTMTTITGLEPYTKYE 1336
Cdd:COG3401 247 GSVTLSWDPVTESD--ATGYRVY----RSNS----------------GDGPFTKVATVTT-----TSYTDTGLTNGTTYY 299
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1337 FRVLAVNMAGSVS--SAWVSERTGESAPvfmIPPSVF---PLSSYSLNISWEKPADNvtrgKVVGYDInmlsEQSPQQSI 1411
Cdd:COG3401 300 YRVTAVDAAGNESapSNVVSVTTDLTPP---AAPSGLtatAVGSSSITLSWTASSDA----DVTGYNV----YRSTSGGG 368
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1796365450 1412 PmaFSQLLHTAKsqELSYTVEGLKPYRIYEFTITLCNSVGCVTSASGAGQTLAAAPAQ 1469
Cdd:COG3401 369 T--YTKIAETVT--TTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAAS 422
|
|
| FN3 super family |
cl27307 |
Fibronectin type 3 domain [General function prediction only]; |
2252-2722 |
3.11e-11 |
|
Fibronectin type 3 domain [General function prediction only];
The actual alignment was detected with superfamily member COG3401:
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 70.03 E-value: 3.11e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2252 YSPDSFNVSWTEPEYPNGVITSYGLYLDGILIHNSSELSYRAYGFAPWSLHSFRVQAC-----TAKGCALGPLVENRTLE 2326
Cdd:COG3401 42 VVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGsgsvgGATNTGLTSSDEVPSPA 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2327 APPEGTVNVFVKTQGSRKAHVRWEAPFRPNGLLTHSVLFTGIFYVDPVG--NNYTLLNVTKVMYSGEETNLWVLIDGLVP 2404
Cdd:COG3401 122 VGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVspDTSATAAVATTSLTVTSTTLVDGGGDIEP 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2405 FTNYTVQVNISN----SQGSLITDPITIAMPPGAPDGVlppRLSSATPTSLQVVWSTPARNNAPGsprYQLQmRSGDSTH 2480
Cdd:COG3401 202 GTTYYYRVAATDtggeSAPSNEVSVTTPTTPPSAPTGL---TATADTPGSVTLSWDPVTESDATG---YRVY-RSNSGDG 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2481 GFLELfsNPSASLSYEVSDLQPYTEYMFRLVASNGFG--SAHSSwipfmTAEDKPGPVVPPILLDVKSRMML-----VTW 2553
Cdd:COG3401 275 PFTKV--ATVTTTSYTDTGLTNGTTYYYRVTAVDAAGneSAPSN-----VVSVTTDLTPPAAPSGLTATAVGsssitLSW 347
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2554 QHPrkSNGVITHYNIY---LHGRLYLR--TPGNVTNCTVMHLHPYTAYKFQVEACTSKGCSLSPESQTVWTLPGAPEGIP 2628
Cdd:COG3401 348 TAS--SDADVTGYNVYrstSGGGTYTKiaETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAASGES 425
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2629 SPELFSDTPTSVIISWQPPTHPNGLVENFTIERRVKGKEEVTTLVTLPRSHSMRFIDKTSALSPWTKYEYRVLMSTLHGG 2708
Cdd:COG3401 426 LTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSV 505
|
490
....*....|....
gi 1796365450 2709 TNSSAWVEVTTRPS 2722
Cdd:COG3401 506 TNSVSVIGASAAAA 519
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
694-733 |
1.08e-10 |
|
Laminin-type epidermal growth factor-like domai;
:
Pssm-ID: 214543 Cd Length: 46 Bit Score: 59.63 E-value: 1.08e-10
10 20 30 40
....*....|....*....|....*....|....*....|
gi 1796365450 694 CNCNTSGTVDGdiTCHQNSGQCKCKANVIGLRCDHCNFGF 733
Cdd:smart00180 1 CDCDPGGSASG--TCDPDTGQCECKPNVTGRRCDRCAPGY 38
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
4826-4927 |
1.09e-10 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
:
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 60.97 E-value: 1.09e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4826 PAPPSGLsspQIGTLASRTASFRWSPPMFPNGVIHSYELQFHvACPPDSALPCTPSQI-ETKYTglgqkasLGGLQPYTT 4904
Cdd:cd00063 1 PSPPTNL---RVTDVTSTSVTLSWTPPEDDGGPITGYVVEYR-EKGSGDWKEVEVTPGsETSYT-------LTGLKPGTE 69
|
90 100
....*....|....*....|....
gi 1796365450 4905 YKLRVVAHNEVG-STASEWISFTT 4927
Cdd:cd00063 70 YEFRVRAVNGGGeSPPSESVTVTT 93
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
1001-1037 |
1.56e-10 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
:
Pssm-ID: 238012 Cd Length: 50 Bit Score: 59.29 E-value: 1.56e-10
10 20 30
....*....|....*....|....*....|....*..
gi 1796365450 1001 PCNCHLSGALNETCHLVTGQCFCKQFVTGSKCDACVP 1037
Cdd:cd00055 1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAP 37
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
3866-3960 |
1.72e-09 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
:
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 57.89 E-value: 1.72e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 3866 APMDLNspvLKALGSACIEIKWMPPEKPNGIIINYFIYRRPAGIEEESVLFVWSEGALEFMDEGdtLRPFTLYEYRVRAC 3945
Cdd:cd00063 3 PPTNLR---VTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTG--LKPGTEYEFRVRAV 77
|
90
....*....|....*
gi 1796365450 3946 NSKGsvESLWSLTQT 3960
Cdd:cd00063 78 NGGG--ESPPSESVT 90
|
|
| FN3 super family |
cl27307 |
Fibronectin type 3 domain [General function prediction only]; |
3927-4190 |
1.74e-09 |
|
Fibronectin type 3 domain [General function prediction only];
The actual alignment was detected with superfamily member COG3401:
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 64.25 E-value: 1.74e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 3927 DEGDTLRPFTLYEYRVRACNSKG----SVESLWSLTQTLEAPPQDFPapwAQATSAHSVLLNWTKPESPNgiISHYRvVY 4002
Cdd:COG3401 194 DGGGDIEPGTTYYYRVAATDTGGesapSNEVSVTTPTTPPSAPTGLT---ATADTPGSVTLSWDPVTESD--ATGYR-VY 267
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4003 QERPDDPTFNSPTvhafTVKGTSHQAHlyGLEPFTTYRIGVVAANHAGEIlSPW------TLIQTLESSPSGLRNfiveQ 4076
Cdd:COG3401 268 RSNSGDGPFTKVA----TVTTTSYTDT--GLTNGTTYYYRVTAVDAAGNE-SAPsnvvsvTTDLTPPAAPSGLTA----T 336
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4077 KENGRALLLQWSEPmrTNGVIKTYNIFSDGFLE--YSGLNR-----QFLFRRLDPFTLYTLTLEACTRAGC--AHSAPQP 4147
Cdd:COG3401 337 AVGSSSITLSWTAS--SDADVTGYNVYRSTSGGgtYTKIAEtvtttSYTDTGLTPGTTYYYKVTAVDAAGNesAPSEEVS 414
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 1796365450 4148 LWTDEAPPDSQL-----APTVHSVKSTSVELSWSEPVNPNGKIIRYEV 4190
Cdd:COG3401 415 ATTASAASGESLtasvdAVPLTDVAGATAAASAASNPGVSAAVLADGG 462
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
4161-4247 |
4.24e-07 |
|
Fibronectin type III domain;
:
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 50.49 E-value: 4.24e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4161 PTVHSVKSTSVELSWSEPVNPNGKIIRYEVIRRcfegkawgnqtiQADEKIVFTEYNTERNTFMYNDTGLQPWTQCEYKI 4240
Cdd:pfam00041 6 LTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYR------------PKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRV 73
|
....*..
gi 1796365450 4241 YTWNSAG 4247
Cdd:pfam00041 74 QAVNGGG 80
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
574-639 |
1.63e-06 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
:
Pssm-ID: 238012 Cd Length: 50 Bit Score: 47.73 E-value: 1.63e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1796365450 574 PCQCNSH---SKSCHYnisvdpfpfehfrgGGGVCDdCEHNTTGRNCELCKDYFFRqvgaDPSAIDVCK 639
Cdd:cd00055 1 PCDCNGHgslSGQCDP--------------GTGQCE-CKPNTTGRRCDRCAPGYYG----LPSQGGGCQ 50
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
4268-4351 |
1.07e-05 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
:
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 47.11 E-value: 1.07e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4268 PPVISYVSMNPQKLLISWIPPEQSNGIIQSYRLQRNEMLYPF-----SFDPVTFNYTDEELLPFSTYSYALQACTSGGCS 4342
Cdd:cd00063 4 PTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDwkeveVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGES 83
|
90
....*....|
gi 1796365450 4343 T-SKPTSITT 4351
Cdd:cd00063 84 PpSESVTVTT 93
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
1956-2051 |
1.85e-05 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
:
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 46.34 E-value: 1.85e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1956 SVPTPSRVRSLNGYSIEVTWDEPVV-RGVIEKYILKaYSEDSTRPPRmpsaSAEFVNTSNLTGILTGLLPFKNYAVTLTA 2034
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEDdGGPITGYVVE-YREKGSGDWK----EVEVTPGSETSYTLTGLKPGTEYEFRVRA 76
|
90
....*....|....*..
gi 1796365450 2035 CTLAGCTESSHALNIST 2051
Cdd:cd00063 77 VNGGGESPPSESVTVTT 93
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1058-1132 |
3.66e-05 |
|
Fibronectin type III domain;
:
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 45.10 E-value: 3.66e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1058 PPPRG---QVQSSSAINLSWSPPDSPNAHWLTYSLlrdgfeIYTTEDQYPYSIQYFLD--------TDLLPYTKYSYYIE 1126
Cdd:pfam00041 1 SAPSNltvTDVTSTSLTVSWTPPPDGNGPITGYEV------EYRPKNSGEPWNEITVPgtttsvtlTGLKPGTEYEVRVQ 74
|
....*.
gi 1796365450 1127 TTNVHG 1132
Cdd:pfam00041 75 AVNGGG 80
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
517-565 |
5.93e-05 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
:
Pssm-ID: 238012 Cd Length: 50 Bit Score: 43.50 E-value: 5.93e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 1796365450 517 RCQCHGHAD---NCDTTSqpYRCLCsqESFTEGLHCDRCLPLYNDKPFRQGD 565
Cdd:cd00055 1 PCDCNGHGSlsgQCDPGT--GQCEC--KPNTTGRRCDRCAPGYYGLPSQGGG 48
|
|
| FN3 super family |
cl27307 |
Fibronectin type 3 domain [General function prediction only]; |
1865-2127 |
7.97e-03 |
|
Fibronectin type 3 domain [General function prediction only];
The actual alignment was detected with superfamily member COG3401:
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 42.68 E-value: 7.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1865 DVKFTRGAVVNLASVSSGAVRVNLDGCLSTDSAVNCRGNDSILVYQGKEQSVYEGGLQPFTEYLYRVIASHEGG-SVYSD 1943
Cdd:COG3401 143 LGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGeSAPSN 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1944 WSRGRTTGAAPqSVPTPSRVRSLNGYSIEVTWDEPVVRGVIEKYILKAYSEDSTrpprmpsaSAEFVNTSNLTGILTGLL 2023
Cdd:COG3401 223 EVSVTTPTTPP-SAPTGLTATADTPGSVTLSWDPVTESDATGYRVYRSNSGDGP--------FTKVATVTTTSYTDTGLT 293
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2024 PFKNYAVTLTACTLAGcTES--SHALNISTPQEAPQEVQPPVAKSLPSSLLL-SWNPPkkANGIITQYCLY----MDGRL 2096
Cdd:COG3401 294 NGTTYYYRVTAVDAAG-NESapSNVVSVTTDLTPPAAPSGLTATAVGSSSITlSWTAS--SDADVTGYNVYrstsGGGTY 370
|
250 260 270
....*....|....*....|....*....|....
gi 1796365450 2097 IY---SGSEENYIVTDLAVFTPHQFLLSACTHVG 2127
Cdd:COG3401 371 TKiaeTVTTTSYTDTGLTPGTTYYYKVTAVDAAG 404
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| LamGL |
smart00560 |
LamG-like jellyroll fold domain; |
146-283 |
3.56e-36 |
|
LamG-like jellyroll fold domain;
Pssm-ID: 214722 [Multi-domain] Cd Length: 133 Bit Score: 135.24 E-value: 3.56e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 146 ASFTLAVWLKPEQQGVMCVIEKtvdGQIVFKLTISEKETMFYYRTV--NGLQPPIKVMTLGRIlvKKWIHLSVQVHQ--T 221
Cdd:smart00560 1 GSFTLEAWVKLESAGGSQPIIT---GAAVAQPTISEKALTFFLRAKsvQGWQTARTGATADWI--GVWVHLAGVYDGgaG 75
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1796365450 222 KISFFINGVEKDHTPFnarTLSGSITDFASGTvQIGQSLNGLEQFVGRMQDFRLYQVALTNR 283
Cdd:smart00560 76 KLSLYVNGVEVATSET---QPSPSSGNLPQGG-RILLGGAGGENFSGRLDEVRVYNRALTAR 133
|
|
| Laminin_N |
pfam00055 |
Laminin N-terminal (Domain VI); |
291-516 |
1.99e-29 |
|
Laminin N-terminal (Domain VI);
Pssm-ID: 459653 Cd Length: 230 Bit Score: 119.61 E-value: 1.99e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 291 GDLL---RLHAQSHCrcpGSHPRvhplaQRYCIPNDAG-----DTADNRVSRLnpeAHPLSFV---NDNDVGTSWVSNvf 359
Cdd:pfam00055 6 GNLAfgrEVSATSTC---GLNGP-----ERYCILSGLEggkkcFICDSRDPHN---SHPPSNLtdsNNGTNETWWQSE-- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 360 TNITQLNQgVTISVDLEnGQYQVFYIIIQFFSPQPTEIRIQRKKENSLDWEDWQYFARNC-GAFGMKNNGDLE-KPDSVN 437
Cdd:pfam00055 73 TGVIQYEN-VNLTLDLG-KEFHFTYLILKFKSPRPAAMVLERSTDFGKTWQPYQYFASDCrRTFGRPSGPSRGiKDDEVI 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 438 CLQL-SNFTPYSRGNVTFSILtpgpNYRPGYNNFYNTPSLQEFVKATQIRFHFH-----GQYYTTETAVNLRHrYYAVDE 511
Cdd:pfam00055 151 CTSEySDISPLTGGEVIFSTL----EGRPSANIFDYSPELQDWLTATNIRIRLLrlhtlGDELLDDPSVLRKY-YYAISD 225
|
....*
gi 1796365450 512 ITISG 516
Cdd:pfam00055 226 ISVGG 230
|
|
| LamG |
cd00110 |
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ... |
1716-1868 |
1.76e-25 |
|
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.
Pssm-ID: 238058 [Multi-domain] Cd Length: 151 Bit Score: 105.58 E-value: 1.76e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1716 GAQFLGAGFLELhPYMFHGGMNFEISFKFRTDQLNGLLLFVYNKDGPDFLAMELKSGILTFRLNTSLAFTQVDllLGLSY 1795
Cdd:cd00110 1 GVSFSGSSYVRL-PTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGSGSLVLS--SKTPL 77
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1796365450 1796 CNGKWNKVIIKKEGSFISASVNG--LMKHASESGDQPLVVNSPVYVGGIPQELLNSYQHlcLEQGFGGCMKDVKF 1868
Cdd:cd00110 78 NDGQWHSVSVERNGRSVTLSVDGerVVESGSPGGSALLNLDGPLYLGGLPEDLKSPGLP--VSPGFVGCIRDLKV 150
|
|
| LamG |
cd00110 |
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ... |
1519-1678 |
2.67e-25 |
|
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.
Pssm-ID: 238058 [Multi-domain] Cd Length: 151 Bit Score: 104.81 E-value: 2.67e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1519 GIRFIGNGYCKFPSSthPVNTDFTGIKASFRTKVPEGLIVFAASpGNQEEYFALQLKKGRLYFLFDPQGSPVEVTTTNdh 1598
Cdd:cd00110 1 GVSFSGSSYVRLPTL--PAPRTRLSISFSFRTTSPNGLLLYAGS-QNGGDFLALELEDGRLVLRYDLGSGSLVLSSKT-- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1599 gkQYSDGKWHEIIAIRHQAFGQITLDGIYTGSSAILNGSTVIGDNTGVFLGGLPRSYtilRKDPEIIQKGFVGCLKDVHF 1678
Cdd:cd00110 76 --PLNDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDL---KSPGLPVSPGFVGCIRDLKV 150
|
|
| Laminin_G_2 |
pfam02210 |
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ... |
1548-1678 |
6.81e-25 |
|
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.
Pssm-ID: 460494 [Multi-domain] Cd Length: 126 Bit Score: 102.88 E-value: 6.81e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1548 FRTKVPEGLIVFAASPGNqeEYFALQLKKGRLYFLFDPQGSPVEVTTTndhGKQYSDGKWHEIIAIRHQAFGQITLDGIY 1627
Cdd:pfam02210 1 FRTRQPNGLLLYAGGGGS--DFLALELVNGRLVLRYDLGSGPESLLSS---GKNLNDGQWHSVRVERNGNTLTLSVDGQT 75
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1796365450 1628 TGSSAILNGSTVIGDNTGVFLGGLPRSytiLRKDPEIIQKGFVGCLKDVHF 1678
Cdd:pfam02210 76 VVSSLPPGESLLLNLNGPLYLGGLPPL---LLLPALPVRAGFVGCIRDVRV 123
|
|
| LamG |
smart00282 |
Laminin G domain; |
1544-1678 |
1.34e-22 |
|
Laminin G domain;
Pssm-ID: 214598 [Multi-domain] Cd Length: 132 Bit Score: 96.64 E-value: 1.34e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1544 IKASFRTKVPEGLIVFAASpGNQEEYFALQLKKGRLYFLFDPQGSPVEVTTTNdhgKQYSDGKWHEIIAIRHQAFGQITL 1623
Cdd:smart00282 2 ISFSFRTTSPNGLLLYAGS-KGGGDYLALELRDGRLVLRYDLGSGPARLTSDP---TPLNDGQWHRVAVERNGRSVTLSV 77
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 1796365450 1624 DGiYTGSSAILNGSTVIGD-NTGVFLGGLPRSytiLRKDPEIIQKGFVGCLKDVHF 1678
Cdd:smart00282 78 DG-GNRVSGESPGGLTILNlDGPLYLGGLPED---LKLPPLPVTPGFRGCIRNLKV 129
|
|
| LamNT |
smart00136 |
Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related ... |
313-516 |
1.18e-21 |
|
Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related protein such as Unc-6/ netrins.
Pssm-ID: 214532 Cd Length: 238 Bit Score: 97.43 E-value: 1.18e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 313 PLAQRYCIPNDAG------DTADNRVSRLNpeaHPLSFV---NDNDVGTSWVSnvfTNITQLNQGVTISVDLENgQYQVF 383
Cdd:smart00136 29 PGPERYCKLVGHTeqgkkcDYCDARNPRRS---HPAENLtdgNNPNNPTWWQS---EPLSNGPQNVNLTLDLGK-EFHVT 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 384 YIIIQFFSPQPTEIRIQRKKENSlDWEDWQYFARNCGA-FGMKNNGDLEKP--DSVNCL-QLSNFTPYSRGNVTFSILTP 459
Cdd:smart00136 102 YVILKFCSPRPSLWILERSDFGK-TWQPWQYFSSDCRRtFGRPPRGPITKGneDEVICTsEYSDIVPLEGGEIAFSLLEG 180
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1796365450 460 gpnyRPGYNNFYNTPSLQEFVKATQIRFHFH-----GQYYTTETAVNLRHRYYAVDEITISG 516
Cdd:smart00136 181 ----RPSATDFDNSPVLQEWVTATNIRVRLTrlrtlGDELMDDRPEVTRRYYYAISDIAVGG 238
|
|
| LamG |
smart00282 |
Laminin G domain; |
1739-1868 |
9.06e-21 |
|
Laminin G domain;
Pssm-ID: 214598 [Multi-domain] Cd Length: 132 Bit Score: 91.25 E-value: 9.06e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1739 EISFKFRTDQLNGLLLFVYNKDGPDFLAMELKSG--ILTFRLNTSLAFTQVDlllGLSYCNGKWNKVIIKKEGSFISASV 1816
Cdd:smart00282 1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGrlVLRYDLGSGPARLTSD---PTPLNDGQWHRVAVERNGRSVTLSV 77
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1796365450 1817 NGLMKHASES--GDQPLVVNSPVYVGGIPQELLNSyqHLCLEQGFGGCMKDVKF 1868
Cdd:smart00282 78 DGGNRVSGESpgGLTILNLDGPLYLGGLPEDLKLP--PLPVTPGFRGCIRNLKV 129
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
4342-4765 |
5.79e-18 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 91.60 E-value: 5.79e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4342 STSKPTSITTLEAAPSEVSPPDLWAVSATQMNVCWSPPTVQNGKITKYLVRydnkeSLAGQGLCLLVSHLQPYSQYNFSL 4421
Cdd:COG3401 51 SPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSG-----SVGGATNTGLTSSDEVPSPAVGTA 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4422 VACTNGGCTASVSKSAWTMEALPENMDSPTLQVTGSESIEITWKPPRNPNGQIRSYelrrDGTIVYTGLETRYRDFTLTP 4501
Cdd:COG3401 126 TTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVA----TTSLTVTSTTLVDGGGDIEP 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4502 GVEYSYTVTASNSQG-GILSPLV---KDRTSPSAPSGMeppKLQARGPQEILVNWDPPvrTNGDIINYTLFIRElfERET 4577
Cdd:COG3401 202 GTTYYYRVAATDTGGeSAPSNEVsvtTPTTPPSAPTGL---TATADTPGSVTLSWDPV--TESDATGYRVYRSN--SGDG 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4578 KIIHINTTHNSfgmqSYIVNQLKPFHRYEIRIQACTTLGCAS--SDWTFIQTPEIAPlmQPPPHLEVQMAPGGfqpTVSL 4655
Cdd:COG3401 275 PFTKVATVTTT----SYTDTGLTNGTTYYYRVTAVDAAGNESapSNVVSVTTDLTPP--AAPSGLTATAVGSS---SITL 345
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4656 LWTGPlqPNGKVLYYELYRrqiATQPRKSNPVLIYNGSSTSFIDSELLPFTEYEYQVWAVNSAGK--APS------SWTW 4727
Cdd:COG3401 346 SWTAS--SDADVTGYNVYR---STSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNesAPSeevsatTASA 420
|
410 420 430
....*....|....*....|....*....|....*...
gi 1796365450 4728 CRTGPAPPEGLRAPTFHVISSTQAVVNISAPGKPNGIV 4765
Cdd:COG3401 421 ASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVL 458
|
|
| Laminin_G_2 |
pfam02210 |
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ... |
1744-1868 |
9.61e-18 |
|
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.
Pssm-ID: 460494 [Multi-domain] Cd Length: 126 Bit Score: 82.47 E-value: 9.61e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1744 FRTDQLNGLLLFVyNKDGPDFLAMELKSGILTFRLNTSLAfTQVDLLLGLSYCNGKWNKVIIKKEGSFISASVNGLMKHA 1823
Cdd:pfam02210 1 FRTRQPNGLLLYA-GGGGSDFLALELVNGRLVLRYDLGSG-PESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVS 78
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 1796365450 1824 S--ESGDQPLVVNSPVYVGGIPQELLNSYQHlcLEQGFGGCMKDVKF 1868
Cdd:pfam02210 79 SlpPGESLLLNLNGPLYLGGLPPLLLLPALP--VRAGFVGCIRDVRV 123
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
3450-3846 |
5.81e-17 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 88.52 E-value: 5.81e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 3450 TIHTGSVNTYSYTDVNLKPYMTYEYRISAWNSYGRG-LSKAVRARTKEDVPqgvSPPTWTKIDNLEDTIV-LNWRKPiqS 3527
Cdd:COG3401 183 TSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESaPSNEVSVTTPTTPP---SAPTGLTATADTPGSVtLSWDPV--T 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 3528 NGPIIYYILLR--NGIERF----RGTSLSFSDKeGIQPFQEYSYQLKACTVAGC-ATSSKVVAATTQGVPesilPPSITA 3600
Cdd:COG3401 258 ESDATGYRVYRsnSGDGPFtkvaTVTTTSYTDT-GLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTP----PAAPSG 332
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 3601 LSAVA-----LHLSWSvpEKSNGVIKEYQI-RQVGKG----LIHTDTTDrRQHTVTGLQPYTNYSFTLTACTSAGCTS-- 3668
Cdd:COG3401 333 LTATAvgsssITLSWT--ASSDADVTGYNVyRSTSGGgtytKIAETVTT-TSYTDTGLTPGTTYYYKVTAVDAAGNESap 409
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 3669 SEPFLGQTLQAAP-----EGVWVTPRHIIINSTTVELYWSLPEKPNGLVSQYQLSRNGNLLFLGGSEEQNFTDKNLEPNS 3743
Cdd:COG3401 410 SEEVSATTASAASgesltASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANL 489
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 3744 RYTYKLEVKTGGGSSASDDYIVQTPMSTPEEIYPPYNITVIGPYSI-FVAWIPPGILIPEIPVEYNVLLNDGSVTPLAFS 3822
Cdd:COG3401 490 SVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASPvTVGASTGDVLITDLVSLTTSASSSVSGAGLGSG 569
|
410 420
....*....|....*....|....*.
gi 1796365450 3823 VGHHQSTLLENLTP--FTQYEIRIQA 3846
Cdd:COG3401 570 NLYLITTLGGSLLTttSTNTNDVAGV 595
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
2685-3074 |
1.13e-14 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 81.20 E-value: 1.13e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2685 DKTSALSPWTKYEYRVLMSTLHGGTNSSAWVEVT---TRPSRPAGVQppvVTVLEPDAVQVTWKPPliQNGDILSYEIH- 2760
Cdd:COG3401 194 DGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTtptTPPSAPTGLT---ATADTPGSVTLSWDPV--TESDATGYRVYr 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2761 --MPDPH---ITLTNVTSAVlsqkVTHLIPFTNYSVTIVAcSGGNGYLGGCTESLptYVTTHPTVPQNVGPLSVIPLSES 2835
Cdd:COG3401 269 snSGDGPftkVATVTTTSYT----DTGLTNGTTYYYRVTA-VDAAGNESAPSNVV--SVTTDLTPPAAPSGLTATAVGSS 341
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2836 YVVISWQPPSkpnGPNL-RYELLRRKIqqplASNPPEDLNRwhnIYSGTQwlYEDKGLSRFTTYEYMLFVHNSVGFT--P 2912
Cdd:COG3401 342 SITLSWTASS---DADVtGYNVYRSTS----GGGTYTKIAE---TVTTTS--YTDTGLTPGTTYYYKVTAVDAAGNEsaP 409
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2913 SREVTVTTLAGLPERGANLTASVLNHTAIDVRWAKPTVQDLQGEVEYYTLFWSSATSNDSLKILPDVNshvighLKPNTE 2992
Cdd:COG3401 410 SEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTV------TATTTD 483
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2993 YWIFISVFNGVHSINSAGLHATTCDGEPQGMLPPEVVIINSTAVRVIWTSP--SNPNGVVTEYSIYVNNKLYKTGMNVPG 3070
Cdd:COG3401 484 TTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASpvTVGASTGDVLITDLVSLTTSASSSVSG 563
|
....
gi 1796365450 3071 SFIL 3074
Cdd:COG3401 564 AGLG 567
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
900-948 |
3.35e-14 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 69.69 E-value: 3.35e-14
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 1796365450 900 CECDSLGTLPGTiCDPISGQCLCVPNRQGRRCNQCQPGFYISPGNATGC 948
Cdd:cd00055 2 CDCNGHGSLSGQ-CDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGGGC 49
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
900-948 |
4.71e-14 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 69.26 E-value: 4.71e-14
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 1796365450 900 CECDSLGTLPGTiCDPISGQCLCVPNRQGRRCNQCQPGFYISPGNatGC 948
Cdd:smart00180 1 CDCDPGGSASGT-CDPDTGQCECKPNVTGRRCDRCAPGYYGDGPP--GC 46
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
900-948 |
5.43e-14 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 68.92 E-value: 5.43e-14
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 1796365450 900 CECDSLGTLPGTiCDPISGQCLCVPNRQGRRCNQCQPGFY-ISPGNATGC 948
Cdd:pfam00053 1 CDCNPHGSLSDT-CDPETGQCLCKPGVTGRHCDRCKPGYYgLPSDPPQGC 49
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
641-691 |
9.85e-14 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 68.15 E-value: 9.85e-14
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 1796365450 641 CDCDTVGTRNGSilCDQIGGQCNCKRHVSGRQCNQCQNGFYNLQELDPDGC 691
Cdd:pfam00053 1 CDCNPHGSLSDT--CDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
640-691 |
1.73e-13 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 67.76 E-value: 1.73e-13
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 1796365450 640 PCDCDTVGTRNGSilCDQIGGQCNCKRHVSGRQCNQCQNGFYNLQElDPDGC 691
Cdd:cd00055 1 PCDCNGHGSLSGQ--CDPGTGQCECKPNTTGRRCDRCAPGYYGLPS-QGGGC 49
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
950-1000 |
2.18e-13 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 67.38 E-value: 2.18e-13
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 1796365450 950 PCSCHTTGAVNHICNSLTGQCVCQDAsIAGQRCDQCKDHYFGFDPQTGRCQ 1000
Cdd:cd00055 1 PCDCNGHGSLSGQCDPGTGQCECKPN-TTGRRCDRCAPGYYGLPSQGGGCQ 50
|
|
| Laminin_G_3 |
pfam13385 |
Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin ... |
146-285 |
2.89e-13 |
|
Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.
Pssm-ID: 463865 [Multi-domain] Cd Length: 151 Bit Score: 70.49 E-value: 2.89e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 146 ASFTLAVWLKPEQ--QGVMCVIEKTVDGQIVFKLTiSEKETMFYYRTVNGLqpPIKVMTLGRILVKKWIHLSVQVHQTKI 223
Cdd:pfam13385 17 SDFTVSAWVKPDSlpGWARAIISSSGGGGYSLGLD-GDGRLRFAVNGGNGG--WDTVTSGASVPLGQWTHVAVTYDGGTL 93
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1796365450 224 SFFINGVEKDhtpfnARTLSGSITDFASGTVQIGQSLNGLEQFVGRMQDFRLYQVALTNREI 285
Cdd:pfam13385 94 RLYVNGVLVG-----SSTLTGGPPPGTGGPLYIGRSPGGDDYFNGLIDEVRIYDRALSAAEI 150
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
641-691 |
3.77e-13 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 66.57 E-value: 3.77e-13
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 1796365450 641 CDCDTVGTRNGSilCDQIGGQCNCKRHVSGRQCNQCQNGFYNlqeLDPDGC 691
Cdd:smart00180 1 CDCDPGGSASGT--CDPDTGQCECKPNVTGRRCDRCAPGYYG---DGPPGC 46
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
747-795 |
3.79e-13 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 66.61 E-value: 3.79e-13
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 1796365450 747 CQCNLHGSVNKFCNPHSGQCECKKEAKGLQCDTCRENFYGLDVTNCKAC 795
Cdd:pfam00053 1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
746-788 |
7.18e-13 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 65.84 E-value: 7.18e-13
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 1796365450 746 PCQCNLHGSVNKFCNPHSGQCECKKEAKGLQCDTCRENFYGLD 788
Cdd:cd00055 1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLP 43
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
2533-2619 |
1.87e-12 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 65.98 E-value: 1.87e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2533 PGPVVPPILLDVKSRMMLVTWQHPRKSNGVITHYNIYLH------GRLYLRTPGNVTNCTVMHLHPYTAYKFQVEACTSK 2606
Cdd:cd00063 1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYRekgsgdWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80
|
90
....*....|...
gi 1796365450 2607 GCSLSPESQTVWT 2619
Cdd:cd00063 81 GESPPSESVTVTT 93
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
847-897 |
3.56e-12 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 63.87 E-value: 3.56e-12
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 1796365450 847 CNCDKTGTINGSllCNKSTGQCPCKLGVTGLRCNQCEPHRYNltiDNFQHC 897
Cdd:smart00180 1 CDCDPGGSASGT--CDPDTGQCECKPNVTGRRCDRCAPGYYG---DGPPGC 46
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
747-792 |
4.00e-12 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 63.48 E-value: 4.00e-12
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 1796365450 747 CQCNLHGSVNKFCNPHSGQCECKKEAKGLQCDTCRENFYGLDVTNC 792
Cdd:smart00180 1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
794-844 |
4.17e-12 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 63.53 E-value: 4.17e-12
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 1796365450 794 ACDCDTAGSLPGTvCNAKTGQCICKPNVEGRQCNKCLEGnFYLRQNNSFLC 844
Cdd:cd00055 1 PCDCNGHGSLSGQ-CDPGTGQCECKPNTTGRRCDRCAPG-YYGLPSQGGGC 49
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
795-834 |
4.37e-12 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 63.48 E-value: 4.37e-12
10 20 30 40
....*....|....*....|....*....|....*....|
gi 1796365450 795 CDCDTAGSLPGTvCNAKTGQCICKPNVEGRQCNKCLEGNF 834
Cdd:smart00180 1 CDCDPGGSASGT-CDPDTGQCECKPNVTGRRCDRCAPGYY 39
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
1242-1357 |
7.24e-12 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 64.44 E-value: 7.24e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1242 PPQRLsppKMQKISSTELHVEWSPPAELNGIIIRYELYMRRLRSTKETTSEESRvfqssgwlsphsfvesanenalkPPQ 1321
Cdd:cd00063 3 PPTNL---RVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTP-----------------------GSE 56
|
90 100 110
....*....|....*....|....*....|....*..
gi 1796365450 1322 TMTTITGLEPYTKYEFRVLAVNMAG-SVSSAWVSERT 1357
Cdd:cd00063 57 TSYTLTGLKPGTEYEFRVRAVNGGGeSPPSESVTVTT 93
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
846-898 |
7.34e-12 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 63.14 E-value: 7.34e-12
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1796365450 846 PCNCDKTGTINGSllCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTiDNFQHCQ 898
Cdd:cd00055 1 PCDCNGHGSLSGQ--CDPGTGQCECKPNTTGRRCDRCAPGYYGLP-SQGGGCQ 50
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
3964-4057 |
7.98e-12 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 64.44 E-value: 7.98e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 3964 PPQDfpaPWAQATSAHSVLLNWTKPESPNGIISHYRVVYQERPDDptfnsPTVHAFTVKGTSHQAHLYGLEPFTTYRIGV 4043
Cdd:cd00063 3 PPTN---LRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSG-----DWKEVEVTPGSETSYTLTGLKPGTEYEFRV 74
|
90
....*....|....
gi 1796365450 4044 VAANHAGEilSPWT 4057
Cdd:cd00063 75 RAVNGGGE--SPPS 86
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
1103-1469 |
8.12e-12 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 71.96 E-value: 8.12e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1103 YPYSIQYFLDTDLLPYTKYSYYIETTNVHGSTrsvAVTYKTKPGVPEGNLTLSYIIPIGSDSVTLTWTTLSNQSGPIEKY 1182
Cdd:COG3401 93 GLTTLTGSGSVGGATNTGLTSSDEVPSPAVGT---ATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVV 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1183 IlscAPLAGGQPCVSYEGHETSATIW-----NLVPFAKYDFSVQACTSGGC-LHSLPITVTTAQAPPQRLSPPKMQKISS 1256
Cdd:COG3401 170 V---SPDTSATAAVATTSLTVTSTTLvdgggDIEPGTTYYYRVAATDTGGEsAPSNEVSVTTPTTPPSAPTGLTATADTP 246
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1257 TELHVEWSPPAELNgiIIRYELYmrrlRSTKettseesrvfqssgwlSPHSFVESANENAlkppqTMTTITGLEPYTKYE 1336
Cdd:COG3401 247 GSVTLSWDPVTESD--ATGYRVY----RSNS----------------GDGPFTKVATVTT-----TSYTDTGLTNGTTYY 299
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1337 FRVLAVNMAGSVS--SAWVSERTGESAPvfmIPPSVF---PLSSYSLNISWEKPADNvtrgKVVGYDInmlsEQSPQQSI 1411
Cdd:COG3401 300 YRVTAVDAAGNESapSNVVSVTTDLTPP---AAPSGLtatAVGSSSITLSWTASSDA----DVTGYNV----YRSTSGGG 368
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1796365450 1412 PmaFSQLLHTAKsqELSYTVEGLKPYRIYEFTITLCNSVGCVTSASGAGQTLAAAPAQ 1469
Cdd:COG3401 369 T--YTKIAETVT--TTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAAS 422
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1150-1227 |
9.67e-12 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 63.97 E-value: 9.67e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1150 GNLTlsyIIPIGSDSVTLTWTTLSNQSGPIEKYILSCAPLAGGQPCVSYE--GHETSATIWNLVPFAKYDFSVQACTSGG 1227
Cdd:pfam00041 4 SNLT---VTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITvpGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
951-996 |
1.29e-11 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 62.33 E-value: 1.29e-11
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 1796365450 951 CSCHTTGAVNHICNSLTGQCVCQDAsIAGQRCDQCKDHYFGFDPQT 996
Cdd:smart00180 1 CDCDPGGSASGTCDPDTGQCECKPN-VTGRRCDRCAPGYYGDGPPG 45
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
847-897 |
1.57e-11 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 61.99 E-value: 1.57e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 1796365450 847 CNCDKTGTINGSllCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTIDNFQHC 897
Cdd:pfam00053 1 CDCNPHGSLSDT--CDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
3969-4057 |
1.61e-11 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 63.20 E-value: 1.61e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 3969 PAPW---AQATSAHSVLLNWTKPESPNGIISHYRVVYQERpddptfNSPTVHA-FTVKGTSHQAHLYGLEPFTTYRIGVV 4044
Cdd:pfam00041 1 SAPSnltVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPK------NSGEPWNeITVPGTTTSVTLTGLKPGTEYEVRVQ 74
|
90
....*....|...
gi 1796365450 4045 AANHAGEilSPWT 4057
Cdd:pfam00041 75 AVNGGGE--GPPS 85
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
1145-1238 |
1.92e-11 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 63.28 E-value: 1.92e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1145 PGVPEgNLTLSyiiPIGSDSVTLTWTTLSNQSGPIEKYILSCAPLAGGQP--CVSYEGHETSATIWNLVPFAKYDFSVQA 1222
Cdd:cd00063 1 PSPPT-NLRVT---DVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWkeVEVTPGSETSYTLTGLKPGTEYEFRVRA 76
|
90
....*....|....*..
gi 1796365450 1223 CTSGGC-LHSLPITVTT 1238
Cdd:cd00063 77 VNGGGEsPPSESVTVTT 93
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
2252-2722 |
3.11e-11 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 70.03 E-value: 3.11e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2252 YSPDSFNVSWTEPEYPNGVITSYGLYLDGILIHNSSELSYRAYGFAPWSLHSFRVQAC-----TAKGCALGPLVENRTLE 2326
Cdd:COG3401 42 VVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGsgsvgGATNTGLTSSDEVPSPA 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2327 APPEGTVNVFVKTQGSRKAHVRWEAPFRPNGLLTHSVLFTGIFYVDPVG--NNYTLLNVTKVMYSGEETNLWVLIDGLVP 2404
Cdd:COG3401 122 VGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVspDTSATAAVATTSLTVTSTTLVDGGGDIEP 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2405 FTNYTVQVNISN----SQGSLITDPITIAMPPGAPDGVlppRLSSATPTSLQVVWSTPARNNAPGsprYQLQmRSGDSTH 2480
Cdd:COG3401 202 GTTYYYRVAATDtggeSAPSNEVSVTTPTTPPSAPTGL---TATADTPGSVTLSWDPVTESDATG---YRVY-RSNSGDG 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2481 GFLELfsNPSASLSYEVSDLQPYTEYMFRLVASNGFG--SAHSSwipfmTAEDKPGPVVPPILLDVKSRMML-----VTW 2553
Cdd:COG3401 275 PFTKV--ATVTTTSYTDTGLTNGTTYYYRVTAVDAAGneSAPSN-----VVSVTTDLTPPAAPSGLTATAVGsssitLSW 347
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2554 QHPrkSNGVITHYNIY---LHGRLYLR--TPGNVTNCTVMHLHPYTAYKFQVEACTSKGCSLSPESQTVWTLPGAPEGIP 2628
Cdd:COG3401 348 TAS--SDADVTGYNVYrstSGGGTYTKiaETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAASGES 425
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2629 SPELFSDTPTSVIISWQPPTHPNGLVENFTIERRVKGKEEVTTLVTLPRSHSMRFIDKTSALSPWTKYEYRVLMSTLHGG 2708
Cdd:COG3401 426 LTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSV 505
|
490
....*....|....
gi 1796365450 2709 TNSSAWVEVTTRPS 2722
Cdd:COG3401 506 TNSVSVIGASAAAA 519
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
2432-2528 |
3.83e-11 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 62.51 E-value: 3.83e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2432 PGAPDGVlppRLSSATPTSLQVVWSTPARNNAPGSpRYQLQMRSGDSThGFLELFSNPSASLSYEVSDLQPYTEYMFRLV 2511
Cdd:cd00063 1 PSPPTNL---RVTDVTSTSVTLSWTPPEDDGGPIT-GYVVEYREKGSG-DWKEVEVTPGSETSYTLTGLKPGTEYEFRVR 75
|
90
....*....|....*...
gi 1796365450 2512 ASNGFG-SAHSSWIPFMT 2528
Cdd:cd00063 76 AVNGGGeSPPSESVTVTT 93
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
795-849 |
4.08e-11 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 60.83 E-value: 4.08e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 1796365450 795 CDCDTAGSLPGTvCNAKTGQCICKPNVEGRQCNKCLEGnFYLRQNNSflclPCNC 849
Cdd:pfam00053 1 CDCNPHGSLSDT-CDPETGQCLCKPGVTGRHCDRCKPG-YYGLPSDP----PQGC 49
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
951-1004 |
7.34e-11 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 60.06 E-value: 7.34e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 1796365450 951 CSCHTTGAVNHICNSLTGQCVCQDaSIAGQRCDQCKDHYFGFDPqtgrCQPCNC 1004
Cdd:pfam00053 1 CDCNPHGSLSDTCDPETGQCLCKP-GVTGRHCDRCKPGYYGLPS----DPPQGC 49
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
694-733 |
1.08e-10 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 59.63 E-value: 1.08e-10
10 20 30 40
....*....|....*....|....*....|....*....|
gi 1796365450 694 CNCNTSGTVDGdiTCHQNSGQCKCKANVIGLRCDHCNFGF 733
Cdd:smart00180 1 CDCDPGGSASG--TCDPDTGQCECKPNVTGRRCDRCAPGY 38
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
4826-4927 |
1.09e-10 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 60.97 E-value: 1.09e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4826 PAPPSGLsspQIGTLASRTASFRWSPPMFPNGVIHSYELQFHvACPPDSALPCTPSQI-ETKYTglgqkasLGGLQPYTT 4904
Cdd:cd00063 1 PSPPTNL---RVTDVTSTSVTLSWTPPEDDGGPITGYVVEYR-EKGSGDWKEVEVTPGsETSYT-------LTGLKPGTE 69
|
90 100
....*....|....*....|....
gi 1796365450 4905 YKLRVVAHNEVG-STASEWISFTT 4927
Cdd:cd00063 70 YEFRVRAVNGGGeSPPSESVTVTT 93
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
693-745 |
1.16e-10 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 59.68 E-value: 1.16e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1796365450 693 PCNCNTSGTVDGdiTCHQNSGQCKCKANVIGLRCDHCNFGFkFLRSFNDVGCE 745
Cdd:cd00055 1 PCDCNGHGSLSG--QCDPGTGQCECKPNTTGRRCDRCAPGY-YGLPSQGGGCQ 50
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
1001-1037 |
1.56e-10 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 59.29 E-value: 1.56e-10
10 20 30
....*....|....*....|....*....|....*..
gi 1796365450 1001 PCNCHLSGALNETCHLVTGQCFCKQFVTGSKCDACVP 1037
Cdd:cd00055 1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAP 37
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
694-749 |
2.94e-10 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 58.52 E-value: 2.94e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 1796365450 694 CNCNTSGTVDGdiTCHQNSGQCKCKANVIGLRCDHCNFGFkflrsFNDVGCEPCQC 749
Cdd:pfam00053 1 CDCNPHGSLSD--TCDPETGQCLCKPGVTGRHCDRCKPGY-----YGLPSDPPQGC 49
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1242-1346 |
3.98e-10 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 59.35 E-value: 3.98e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1242 PPQRLSppkMQKISSTELHVEWSPPAELNGIIIRYELymrrlrsTKETTSEESRVFQSSgwlsphsfvesanenaLKPPQ 1321
Cdd:pfam00041 2 APSNLT---VTDVTSTSLTVSWTPPPDGNGPITGYEV-------EYRPKNSGEPWNEIT----------------VPGTT 55
|
90 100
....*....|....*....|....*
gi 1796365450 1322 TMTTITGLEPYTKYEFRVLAVNMAG 1346
Cdd:pfam00041 56 TSVTLTGLKPGTEYEVRVQAVNGGG 80
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
4529-4627 |
4.69e-10 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 59.43 E-value: 4.69e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4529 PSAPSGmepPKLQARGPQEILVNWDPPVRTNGDIINYTLFIRELFERETKIIHINTTHNSfgmqSYIVNQLKPFHRYEIR 4608
Cdd:cd00063 1 PSPPTN---LRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSET----SYTLTGLKPGTEYEFR 73
|
90 100
....*....|....*....|
gi 1796365450 4609 IQACTTLGC-ASSDWTFIQT 4627
Cdd:cd00063 74 VRAVNGGGEsPPSESVTVTT 93
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
1002-1037 |
1.40e-09 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 56.55 E-value: 1.40e-09
10 20 30
....*....|....*....|....*....|....*.
gi 1796365450 1002 CNCHLSGALNETCHLVTGQCFCKQFVTGSKCDACVP 1037
Cdd:smart00180 1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAP 36
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
1002-1037 |
1.45e-09 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 56.59 E-value: 1.45e-09
10 20 30
....*....|....*....|....*....|....*.
gi 1796365450 1002 CNCHLSGALNETCHLVTGQCFCKQFVTGSKCDACVP 1037
Cdd:pfam00053 1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKP 36
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
3866-3960 |
1.72e-09 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 57.89 E-value: 1.72e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 3866 APMDLNspvLKALGSACIEIKWMPPEKPNGIIINYFIYRRPAGIEEESVLFVWSEGALEFMDEGdtLRPFTLYEYRVRAC 3945
Cdd:cd00063 3 PPTNLR---VTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTG--LKPGTEYEFRVRAV 77
|
90
....*....|....*
gi 1796365450 3946 NSKGsvESLWSLTQT 3960
Cdd:cd00063 78 NGGG--ESPPSESVT 90
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
3927-4190 |
1.74e-09 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 64.25 E-value: 1.74e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 3927 DEGDTLRPFTLYEYRVRACNSKG----SVESLWSLTQTLEAPPQDFPapwAQATSAHSVLLNWTKPESPNgiISHYRvVY 4002
Cdd:COG3401 194 DGGGDIEPGTTYYYRVAATDTGGesapSNEVSVTTPTTPPSAPTGLT---ATADTPGSVTLSWDPVTESD--ATGYR-VY 267
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4003 QERPDDPTFNSPTvhafTVKGTSHQAHlyGLEPFTTYRIGVVAANHAGEIlSPW------TLIQTLESSPSGLRNfiveQ 4076
Cdd:COG3401 268 RSNSGDGPFTKVA----TVTTTSYTDT--GLTNGTTYYYRVTAVDAAGNE-SAPsnvvsvTTDLTPPAAPSGLTA----T 336
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4077 KENGRALLLQWSEPmrTNGVIKTYNIFSDGFLE--YSGLNR-----QFLFRRLDPFTLYTLTLEACTRAGC--AHSAPQP 4147
Cdd:COG3401 337 AVGSSSITLSWTAS--SDADVTGYNVYRSTSGGgtYTKIAEtvtttSYTDTGLTPGTTYYYKVTAVDAAGNesAPSEEVS 414
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 1796365450 4148 LWTDEAPPDSQL-----APTVHSVKSTSVELSWSEPVNPNGKIIRYEV 4190
Cdd:COG3401 415 ATTASAASGESLtasvdAVPLTDVAGATAAASAASNPGVSAAVLADGG 462
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
3590-3676 |
2.07e-09 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 57.51 E-value: 2.07e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 3590 PESILPPSITALSAVALHLSWSVPEKSNGVIKEYQIRQVGKGL-----IHTDTTDRRQHTVTGLQPYTNYSFTLTACTSA 3664
Cdd:cd00063 1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSgdwkeVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80
|
90
....*....|...
gi 1796365450 3665 GC-TSSEPFLGQT 3676
Cdd:cd00063 81 GEsPPSESVTVTT 93
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
3596-3665 |
2.35e-09 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 57.04 E-value: 2.35e-09
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1796365450 3596 PSITALSAVALHLSWSVPEKSNGVIKEYQI--RQVGKGLIHTDTT---DRRQHTVTGLQPYTNYSFTLTACTSAG 3665
Cdd:pfam00041 6 LTVTDVTSTSLTVSWTPPPDGNGPITGYEVeyRPKNSGEPWNEITvpgTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
2724-2799 |
2.77e-09 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 57.12 E-value: 2.77e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2724 PAGVQPPVVTVLEPDAVQVTWKPPLIQNGDILSYEIHM----PDPHITLTNVTSAVLSQKVTHLIPFTNYSVTIVACSGG 2799
Cdd:cd00063 1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYrekgSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
2441-2522 |
4.48e-09 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 56.27 E-value: 4.48e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2441 PRLSSATPTSLQVVWSTPARNNAPGSpRYQLQMRSGDSTHGFLElFSNPSASLSYEVSDLQPYTEYMFRLVASNGFGSAH 2520
Cdd:pfam00041 6 LTVTDVTSTSLTVSWTPPPDGNGPIT-GYEVEYRPKNSGEPWNE-ITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGP 83
|
..
gi 1796365450 2521 SS 2522
Cdd:pfam00041 84 PS 85
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
1242-1347 |
4.57e-09 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 56.08 E-value: 4.57e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1242 PPQRLsppKMQKISSTELHVEWSPPAELNGI--IIRYELYMRRLRSTKETTSEesrvfqssgwlsphsfvesanenalKP 1319
Cdd:smart00060 3 PPSNL---RVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYREEGSEWKEVNV-------------------------TP 54
|
90 100
....*....|....*....|....*...
gi 1796365450 1320 PQTMTTITGLEPYTKYEFRVLAVNMAGS 1347
Cdd:smart00060 55 SSTSYTLTGLKPGTEYEFRVRAVNGAGE 82
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
2435-2518 |
5.78e-09 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 56.08 E-value: 5.78e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2435 PDGVLPPRLSSATPTSLQVVWSTPARNNaPGSPRYQLQMRSGDSTHGFLELFSNPSaSLSYEVSDLQPYTEYMFRLVASN 2514
Cdd:smart00060 1 PSPPSNLRVTDVTSTSVTLSWEPPPDDG-ITGYIVGYRVEYREEGSEWKEVNVTPS-STSYTLTGLKPGTEYEFRVRAVN 78
|
....
gi 1796365450 2515 GFGS 2518
Cdd:smart00060 79 GAGE 82
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
1368-1451 |
6.96e-09 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 55.70 E-value: 6.96e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1368 PSVFPLSSYSLNISWEKPADNVTRGKVVGYDINMLSEQSPQQSIpmafsqllhTAKSQELSYTVEGLKPYRIYEFTITLC 1447
Cdd:smart00060 7 LRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEV---------NVTPSSTSYTLTGLKPGTEYEFRVRAV 77
|
....
gi 1796365450 1448 NSVG 1451
Cdd:smart00060 78 NGAG 81
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
2727-2799 |
1.11e-08 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 55.11 E-value: 1.11e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2727 VQPPVVTVLEPDAVQVTWKPPLIQNGDILSYEIH-------MPDPHITLTNVTSAVlsqKVTHLIPFTNYSVTIVACSGG 2799
Cdd:pfam00041 3 PSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEyrpknsgEPWNEITVPGTTTSV---TLTGLKPGTEYEVRVQAVNGG 79
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
3964-4051 |
1.38e-08 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 54.93 E-value: 1.38e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 3964 PPQDfpaPWAQATSAHSVLLNWTKPESPNGI--ISHYRVVYQErpddptfNSPTVHAFTVKGTSHQAHLYGLEPFTTYRI 4041
Cdd:smart00060 3 PPSN---LRVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYRE-------EGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
|
90
....*....|
gi 1796365450 4042 GVVAANHAGE 4051
Cdd:smart00060 73 RVRAVNGAGE 82
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
2534-2614 |
1.42e-08 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 54.73 E-value: 1.42e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2534 GPVVPPILLDVKSRMMLVTWQHPRKSNGVITHYNIYL------HGRLYLRTPGNVTNCTVMHLHPYTAYKFQVEACTSKG 2607
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYrpknsgEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
....*..
gi 1796365450 2608 CslSPES 2614
Cdd:pfam00041 81 E--GPPS 85
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
2533-2609 |
6.39e-08 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 53.00 E-value: 6.39e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2533 PGPVVPPILLDVKSRMMLVTWQHPRKSNGV--ITHYNIYLHGRLY----LRTPGNVTNCTVMHLHPYTAYKFQVEACTSK 2606
Cdd:smart00060 1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYREEGSewkeVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80
|
...
gi 1796365450 2607 GCS 2609
Cdd:smart00060 81 GEG 83
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
3735-4027 |
8.98e-08 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 58.86 E-value: 8.98e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 3735 TDKNLEPNSRYTYKLEVKTGGGSSASDDYIVQTPMSTPEEiyPPYNITV--IGPYSIFVAWIPPgiliPEIPVE-YNVLL 3811
Cdd:COG3401 195 GGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPS--APTGLTAtaDTPGSVTLSWDPV----TESDATgYRVYR 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 3812 ---NDGSVTPLAFSVGhhQSTLLENLTPFTQYEIRIQA--CQNGSCGVSSRMFVKTPEAAPmdlNSPV-LKA--LGSACI 3883
Cdd:COG3401 269 snsGDGPFTKVATVTT--TSYTDTGLTNGTTYYYRVTAvdAAGNESAPSNVVSVTTDLTPP---AAPSgLTAtaVGSSSI 343
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 3884 EIKWMPPekPNGIIINYFIYRRPAGIEEESVLFVwSEGALEFMDEGdtLRPFTLYEYRVRACNSKGsVESLWS----LTQ 3959
Cdd:COG3401 344 TLSWTAS--SDADVTGYNVYRSTSGGGTYTKIAE-TVTTTSYTDTG--LTPGTTYYYKVTAVDAAG-NESAPSeevsATT 417
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 3960 TLEAPPQDFPAPWAQATSAHSVLLNW-TKPESPNGIISH-YRVVYQERPDDPTFNSPTVHAFTVKGTSHQ 4027
Cdd:COG3401 418 ASAASGESLTASVDAVPLTDVAGATAaASAASNPGVSAAvLADGGDTGNAVPFTTTSSTVTATTTDTTTA 487
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
4357-4428 |
1.17e-07 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 52.42 E-value: 1.17e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4357 SEVSPPDLWAVSATQMNVCWSPPTVQNGKITKYLVRY--------DNKESLAGQGLCLLVSHLQPYSQYNFSLVACTNGG 4428
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYrpknsgepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
4529-4616 |
1.30e-07 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 52.23 E-value: 1.30e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4529 PSAPSGmepPKLQARGPQEILVNWDPPVRTNGD--IINYTLFIRELFERETKIIHINTTHnsfgmqSYIVNQLKPFHRYE 4606
Cdd:smart00060 1 PSPPSN---LRVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYREEGSEWKEVNVTPSST------SYTLTGLKPGTEYE 71
|
90
....*....|
gi 1796365450 4607 IRIQACTTLG 4616
Cdd:smart00060 72 FRVRAVNGAG 81
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
3590-3665 |
1.73e-07 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 51.85 E-value: 1.73e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 3590 PESILPPSITALSAVALHLSWSVPEKSNGV--IKEYQIRQVGKG---LIHTDTTDRRQHTVTGLQPYTNYSFTLTACTSA 3664
Cdd:smart00060 1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYREEGsewKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80
|
.
gi 1796365450 3665 G 3665
Cdd:smart00060 81 G 81
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
4826-4917 |
3.30e-07 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 51.08 E-value: 3.30e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4826 PAPPSGLsspQIGTLASRTASFRWSPPMFPNGviHSYELQFHVACPPDSA--LPCTPSQIETKYTglgqkasLGGLQPYT 4903
Cdd:smart00060 1 PSPPSNL---RVTDVTSTSVTLSWEPPPDDGI--TGYIVGYRVEYREEGSewKEVNVTPSSTSYT-------LTGLKPGT 68
|
90
....*....|....
gi 1796365450 4904 TYKLRVVAHNEVGS 4917
Cdd:smart00060 69 EYEFRVRAVNGAGE 82
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
2724-2799 |
4.13e-07 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 50.69 E-value: 4.13e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2724 PAGVQPPVVTVLEPDAVQVTWKPPLIQNGD--ILSYEIHMPDPHITLT--NVTSAVLSQKVTHLIPFTNYSVTIVACSGG 2799
Cdd:smart00060 1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYREEGSEWKevNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
4161-4247 |
4.24e-07 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 50.49 E-value: 4.24e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4161 PTVHSVKSTSVELSWSEPVNPNGKIIRYEVIRRcfegkawgnqtiQADEKIVFTEYNTERNTFMYNDTGLQPWTQCEYKI 4240
Cdd:pfam00041 6 LTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYR------------PKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRV 73
|
....*..
gi 1796365450 4241 YTWNSAG 4247
Cdd:pfam00041 74 QAVNGGG 80
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
4828-4916 |
6.52e-07 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 50.11 E-value: 6.52e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4828 PPSGLSSPQIGtlaSRTASFRWSPPMFPNGVIHSYELQFHVACPPDSALPCTPSQIETKYTglgqkasLGGLQPYTTYKL 4907
Cdd:pfam00041 2 APSNLTVTDVT---STSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVT-------LTGLKPGTEYEV 71
|
....*....
gi 1796365450 4908 RVVAHNEVG 4916
Cdd:pfam00041 72 RVQAVNGGG 80
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
4161-4247 |
7.26e-07 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 50.19 E-value: 7.26e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4161 PTVHSVKSTSVELSWSEPVNPNGKIIRYEVIRRCFEGKAWgnqtiqadeKIVFTEYNTERNtfmYNDTGLQPWTQCEYKI 4240
Cdd:cd00063 7 LRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDW---------KEVEVTPGSETS---YTLTGLKPGTEYEFRV 74
|
....*..
gi 1796365450 4241 YTWNSAG 4247
Cdd:cd00063 75 RAVNGGG 81
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
3873-3950 |
1.35e-06 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 49.15 E-value: 1.35e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 3873 PVLKALGSACIEIKWMPPEKPNGI--IINYFIYRRPAGIEEESVLFVWSEGALEFMDegdtLRPFTLYEYRVRACNSKGS 3950
Cdd:smart00060 7 LRVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTG----LKPGTEYEFRVRAVNGAGE 82
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
574-639 |
1.63e-06 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 47.73 E-value: 1.63e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1796365450 574 PCQCNSH---SKSCHYnisvdpfpfehfrgGGGVCDdCEHNTTGRNCELCKDYFFRqvgaDPSAIDVCK 639
Cdd:cd00055 1 PCDCNGHgslSGQCDP--------------GTGQCE-CKPNTTGRRCDRCAPGYYG----LPSQGGGCQ 50
|
|
| COG4733 |
COG4733 |
Phage-related protein, tail protein J [Mobilome: prophages, transposons]; |
3938-4080 |
4.43e-06 |
|
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
Pssm-ID: 443767 [Multi-domain] Cd Length: 978 Bit Score: 53.41 E-value: 4.43e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 3938 YEYRVRACNSKGsVESLWSLTQT-----LEAPPqdfPAP-WAQATSA-HSVLLNWTKPESPNgiISHYRVVYQERPDdpt 4010
Cdd:COG4733 599 YEVRVRAINALG-VSSAWAASSEttvtgKTAPP---PAPtGLTATGGlGGITLSWSFPVDAD--TLRTEIRYSTTGD--- 669
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4011 FNSPTVHAFTVKGTSHQAHlyGLEPFTTYRIGVVAANHAGEIlSPWTLIQTLESSPSGLRNFIVEQKENG 4080
Cdd:COG4733 670 WASATVAQALYPGNTYTLA--GLKAGQTYYYRARAVDRSGNV-SAWWVSGQASADAAGILDAITGQILET 736
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
4155-4247 |
7.61e-06 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 47.22 E-value: 7.61e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4155 PDSQLAPTVHSVKSTSVELSWSEPVNPN--GKIIRYEVIRRcfegkawgnqtiqaDEKIVFTEYNTERNTFMYNDTGLQP 4232
Cdd:smart00060 1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGitGYIVGYRVEYR--------------EEGSEWKEVNVTPSSTSYTLTGLKP 66
|
90
....*....|....*
gi 1796365450 4233 WTQCEYKIYTWNSAG 4247
Cdd:smart00060 67 GTEYEFRVRAVNGAG 81
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
4268-4351 |
1.07e-05 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 47.11 E-value: 1.07e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4268 PPVISYVSMNPQKLLISWIPPEQSNGIIQSYRLQRNEMLYPF-----SFDPVTFNYTDEELLPFSTYSYALQACTSGGCS 4342
Cdd:cd00063 4 PTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDwkeveVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGES 83
|
90
....*....|
gi 1796365450 4343 T-SKPTSITT 4351
Cdd:cd00063 84 PpSESVTVTT 93
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
1956-2051 |
1.85e-05 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 46.34 E-value: 1.85e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1956 SVPTPSRVRSLNGYSIEVTWDEPVV-RGVIEKYILKaYSEDSTRPPRmpsaSAEFVNTSNLTGILTGLLPFKNYAVTLTA 2034
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEDdGGPITGYVVE-YREKGSGDWK----EVEVTPGSETSYTLTGLKPGTEYEFRVRA 76
|
90
....*....|....*..
gi 1796365450 2035 CTLAGCTESSHALNIST 2051
Cdd:cd00063 77 VNGGGESPPSESVTVTT 93
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1956-2044 |
2.38e-05 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 45.87 E-value: 2.38e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1956 SVPTPSRVRSLNGYSIEVTWDEP-VVRGVIEKYILKAYSEDSTRPPRmpsasaEFVNTSNLTG-ILTGLLPFKNYAVTLT 2033
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPpDGNGPITGYEVEYRPKNSGEPWN------EITVPGTTTSvTLTGLKPGTEYEVRVQ 74
|
90
....*....|.
gi 1796365450 2034 ACTLAGCTESS 2044
Cdd:pfam00041 75 AVNGGGEGPPS 85
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
4262-4342 |
2.84e-05 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 45.48 E-value: 2.84e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4262 PPEGLSppvISYVsmNPQKLLISWIPPEQSNGIIQSYRLQR---NEMLYPFSF--DPVTFNYTDEELLPFSTYSYALQAC 4336
Cdd:pfam00041 2 APSNLT---VTDV--TSTSLTVSWTPPPDGNGPITGYEVEYrpkNSGEPWNEItvPGTTTSVTLTGLKPGTEYEVRVQAV 76
|
....*.
gi 1796365450 4337 TSGGCS 4342
Cdd:pfam00041 77 NGGGEG 82
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1058-1132 |
3.66e-05 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 45.10 E-value: 3.66e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1058 PPPRG---QVQSSSAINLSWSPPDSPNAHWLTYSLlrdgfeIYTTEDQYPYSIQYFLD--------TDLLPYTKYSYYIE 1126
Cdd:pfam00041 1 SAPSNltvTDVTSTSLTVSWTPPPDGNGPITGYEV------EYRPKNSGEPWNEITVPgtttsvtlTGLKPGTEYEVRVQ 74
|
....*.
gi 1796365450 1127 TTNVHG 1132
Cdd:pfam00041 75 AVNGGG 80
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
575-629 |
4.72e-05 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 43.45 E-value: 4.72e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 1796365450 575 CQCN---SHSKSCHYNisvdpfpfehfrggGGVCDdCEHNTTGRNCELCKDYFFRQVG 629
Cdd:smart00180 1 CDCDpggSASGTCDPD--------------TGQCE-CKPNVTGRRCDRCAPGYYGDGP 43
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
517-565 |
5.93e-05 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 43.50 E-value: 5.93e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 1796365450 517 RCQCHGHAD---NCDTTSqpYRCLCsqESFTEGLHCDRCLPLYNDKPFRQGD 565
Cdd:cd00055 1 PCDCNGHGSlsgQCDPGT--GQCEC--KPNTTGRRCDRCAPGYYGLPSQGGG 48
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
3883-3949 |
6.52e-05 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 44.33 E-value: 6.52e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1796365450 3883 IEIKWMPPEKPNGIIINYFIYRRPAGIEEESVLF--VWSEGALEFMDegdtLRPFTLYEYRVRACNSKG 3949
Cdd:pfam00041 16 LTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEItvPGTTTSVTLTG----LKPGTEYEVRVQAVNGGG 80
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
575-632 |
1.13e-04 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 42.73 E-value: 1.13e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1796365450 575 CQCN---SHSKSCHynisvdpfpfehfrGGGGVCDdCEHNTTGRNCELCKDYFFRQVGADP 632
Cdd:pfam00053 1 CDCNphgSLSDTCD--------------PETGQCL-CKPGVTGRHCDRCKPGYYGLPSDPP 46
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
518-560 |
3.74e-04 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 41.18 E-value: 3.74e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 1796365450 518 CQCHGHA---DNCDttSQPYRCLCSQesFTEGLHCDRCLPLYNDKP 560
Cdd:pfam00053 1 CDCNPHGslsDTCD--PETGQCLCKP--GVTGRHCDRCKPGYYGLP 42
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
4267-4342 |
3.82e-04 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 42.22 E-value: 3.82e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4267 SPPVISYVSMNPQKLLISWIPPEQSNGI--IQSYRLQRNEMLYPF---SFDPVTFNYTDEELLPFSTYSYALQACTSGGC 4341
Cdd:smart00060 3 PPSNLRVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYREEGSEWkevNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGE 82
|
.
gi 1796365450 4342 S 4342
Cdd:smart00060 83 G 83
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
1060-1143 |
1.23e-03 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 40.94 E-value: 1.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1060 PRGQVQSSSAINLSWSPPDSPNAHWLTYSLLR--DGFEIYTTEDQYPYSIQYFLDTDLLPYTKYSYYIETTNVHG-STRS 1136
Cdd:cd00063 7 LRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYreKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGeSPPS 86
|
....*..
gi 1796365450 1137 VAVTYKT 1143
Cdd:cd00063 87 ESVTVTT 93
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
1956-2039 |
1.52e-03 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 40.68 E-value: 1.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1956 SVPTPSRVRSLNGYSIEVTWDEPVvRGVIEKYILKAYSEDSTRPPRMPSASaefVNTSNLTGILTGLLPFKNYAVTLTAC 2035
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPP-DDGITGYIVGYRVEYREEGSEWKEVN---VTPSSTSYTLTGLKPGTEYEFRVRAV 77
|
....
gi 1796365450 2036 TLAG 2039
Cdd:smart00060 78 NGAG 81
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
518-561 |
1.63e-03 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 39.22 E-value: 1.63e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 1796365450 518 CQCH--GHADN-CDTTSqpYRCLCsqESFTEGLHCDRCLPLYNDKPF 561
Cdd:smart00180 1 CDCDpgGSASGtCDPDT--GQCEC--KPNVTGRRCDRCAPGYYGDGP 43
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
1058-1133 |
2.16e-03 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 40.29 E-value: 2.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1058 PPPRGQVQ----SSSAINLSWSPPDSPNAHW--LTYSLLRDGFEIYTTEDQYPYSIQYFLDTDLLPYTKYSYYIETTNVH 1131
Cdd:smart00060 1 PSPPSNLRvtdvTSTSVTLSWEPPPDDGITGyiVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80
|
..
gi 1796365450 1132 GS 1133
Cdd:smart00060 81 GE 82
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
1865-2127 |
7.97e-03 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 42.68 E-value: 7.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1865 DVKFTRGAVVNLASVSSGAVRVNLDGCLSTDSAVNCRGNDSILVYQGKEQSVYEGGLQPFTEYLYRVIASHEGG-SVYSD 1943
Cdd:COG3401 143 LGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGeSAPSN 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1944 WSRGRTTGAAPqSVPTPSRVRSLNGYSIEVTWDEPVVRGVIEKYILKAYSEDSTrpprmpsaSAEFVNTSNLTGILTGLL 2023
Cdd:COG3401 223 EVSVTTPTTPP-SAPTGLTATADTPGSVTLSWDPVTESDATGYRVYRSNSGDGP--------FTKVATVTTTSYTDTGLT 293
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2024 PFKNYAVTLTACTLAGcTES--SHALNISTPQEAPQEVQPPVAKSLPSSLLL-SWNPPkkANGIITQYCLY----MDGRL 2096
Cdd:COG3401 294 NGTTYYYRVTAVDAAG-NESapSNVVSVTTDLTPPAAPSGLTATAVGSSSITlSWTAS--SDADVTGYNVYrstsGGGTY 370
|
250 260 270
....*....|....*....|....*....|....
gi 1796365450 2097 IY---SGSEENYIVTDLAVFTPHQFLLSACTHVG 2127
Cdd:COG3401 371 TKiaeTVTTTSYTDTGLTPGTTYYYKVTAVDAAG 404
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| LamGL |
smart00560 |
LamG-like jellyroll fold domain; |
146-283 |
3.56e-36 |
|
LamG-like jellyroll fold domain;
Pssm-ID: 214722 [Multi-domain] Cd Length: 133 Bit Score: 135.24 E-value: 3.56e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 146 ASFTLAVWLKPEQQGVMCVIEKtvdGQIVFKLTISEKETMFYYRTV--NGLQPPIKVMTLGRIlvKKWIHLSVQVHQ--T 221
Cdd:smart00560 1 GSFTLEAWVKLESAGGSQPIIT---GAAVAQPTISEKALTFFLRAKsvQGWQTARTGATADWI--GVWVHLAGVYDGgaG 75
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1796365450 222 KISFFINGVEKDHTPFnarTLSGSITDFASGTvQIGQSLNGLEQFVGRMQDFRLYQVALTNR 283
Cdd:smart00560 76 KLSLYVNGVEVATSET---QPSPSSGNLPQGG-RILLGGAGGENFSGRLDEVRVYNRALTAR 133
|
|
| Laminin_N |
pfam00055 |
Laminin N-terminal (Domain VI); |
291-516 |
1.99e-29 |
|
Laminin N-terminal (Domain VI);
Pssm-ID: 459653 Cd Length: 230 Bit Score: 119.61 E-value: 1.99e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 291 GDLL---RLHAQSHCrcpGSHPRvhplaQRYCIPNDAG-----DTADNRVSRLnpeAHPLSFV---NDNDVGTSWVSNvf 359
Cdd:pfam00055 6 GNLAfgrEVSATSTC---GLNGP-----ERYCILSGLEggkkcFICDSRDPHN---SHPPSNLtdsNNGTNETWWQSE-- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 360 TNITQLNQgVTISVDLEnGQYQVFYIIIQFFSPQPTEIRIQRKKENSLDWEDWQYFARNC-GAFGMKNNGDLE-KPDSVN 437
Cdd:pfam00055 73 TGVIQYEN-VNLTLDLG-KEFHFTYLILKFKSPRPAAMVLERSTDFGKTWQPYQYFASDCrRTFGRPSGPSRGiKDDEVI 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 438 CLQL-SNFTPYSRGNVTFSILtpgpNYRPGYNNFYNTPSLQEFVKATQIRFHFH-----GQYYTTETAVNLRHrYYAVDE 511
Cdd:pfam00055 151 CTSEySDISPLTGGEVIFSTL----EGRPSANIFDYSPELQDWLTATNIRIRLLrlhtlGDELLDDPSVLRKY-YYAISD 225
|
....*
gi 1796365450 512 ITISG 516
Cdd:pfam00055 226 ISVGG 230
|
|
| LamG |
cd00110 |
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ... |
1716-1868 |
1.76e-25 |
|
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.
Pssm-ID: 238058 [Multi-domain] Cd Length: 151 Bit Score: 105.58 E-value: 1.76e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1716 GAQFLGAGFLELhPYMFHGGMNFEISFKFRTDQLNGLLLFVYNKDGPDFLAMELKSGILTFRLNTSLAFTQVDllLGLSY 1795
Cdd:cd00110 1 GVSFSGSSYVRL-PTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGSGSLVLS--SKTPL 77
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1796365450 1796 CNGKWNKVIIKKEGSFISASVNG--LMKHASESGDQPLVVNSPVYVGGIPQELLNSYQHlcLEQGFGGCMKDVKF 1868
Cdd:cd00110 78 NDGQWHSVSVERNGRSVTLSVDGerVVESGSPGGSALLNLDGPLYLGGLPEDLKSPGLP--VSPGFVGCIRDLKV 150
|
|
| LamG |
cd00110 |
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ... |
1519-1678 |
2.67e-25 |
|
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.
Pssm-ID: 238058 [Multi-domain] Cd Length: 151 Bit Score: 104.81 E-value: 2.67e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1519 GIRFIGNGYCKFPSSthPVNTDFTGIKASFRTKVPEGLIVFAASpGNQEEYFALQLKKGRLYFLFDPQGSPVEVTTTNdh 1598
Cdd:cd00110 1 GVSFSGSSYVRLPTL--PAPRTRLSISFSFRTTSPNGLLLYAGS-QNGGDFLALELEDGRLVLRYDLGSGSLVLSSKT-- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1599 gkQYSDGKWHEIIAIRHQAFGQITLDGIYTGSSAILNGSTVIGDNTGVFLGGLPRSYtilRKDPEIIQKGFVGCLKDVHF 1678
Cdd:cd00110 76 --PLNDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDL---KSPGLPVSPGFVGCIRDLKV 150
|
|
| Laminin_G_2 |
pfam02210 |
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ... |
1548-1678 |
6.81e-25 |
|
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.
Pssm-ID: 460494 [Multi-domain] Cd Length: 126 Bit Score: 102.88 E-value: 6.81e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1548 FRTKVPEGLIVFAASPGNqeEYFALQLKKGRLYFLFDPQGSPVEVTTTndhGKQYSDGKWHEIIAIRHQAFGQITLDGIY 1627
Cdd:pfam02210 1 FRTRQPNGLLLYAGGGGS--DFLALELVNGRLVLRYDLGSGPESLLSS---GKNLNDGQWHSVRVERNGNTLTLSVDGQT 75
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1796365450 1628 TGSSAILNGSTVIGDNTGVFLGGLPRSytiLRKDPEIIQKGFVGCLKDVHF 1678
Cdd:pfam02210 76 VVSSLPPGESLLLNLNGPLYLGGLPPL---LLLPALPVRAGFVGCIRDVRV 123
|
|
| LamG |
smart00282 |
Laminin G domain; |
1544-1678 |
1.34e-22 |
|
Laminin G domain;
Pssm-ID: 214598 [Multi-domain] Cd Length: 132 Bit Score: 96.64 E-value: 1.34e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1544 IKASFRTKVPEGLIVFAASpGNQEEYFALQLKKGRLYFLFDPQGSPVEVTTTNdhgKQYSDGKWHEIIAIRHQAFGQITL 1623
Cdd:smart00282 2 ISFSFRTTSPNGLLLYAGS-KGGGDYLALELRDGRLVLRYDLGSGPARLTSDP---TPLNDGQWHRVAVERNGRSVTLSV 77
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 1796365450 1624 DGiYTGSSAILNGSTVIGD-NTGVFLGGLPRSytiLRKDPEIIQKGFVGCLKDVHF 1678
Cdd:smart00282 78 DG-GNRVSGESPGGLTILNlDGPLYLGGLPED---LKLPPLPVTPGFRGCIRNLKV 129
|
|
| LamNT |
smart00136 |
Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related ... |
313-516 |
1.18e-21 |
|
Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related protein such as Unc-6/ netrins.
Pssm-ID: 214532 Cd Length: 238 Bit Score: 97.43 E-value: 1.18e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 313 PLAQRYCIPNDAG------DTADNRVSRLNpeaHPLSFV---NDNDVGTSWVSnvfTNITQLNQGVTISVDLENgQYQVF 383
Cdd:smart00136 29 PGPERYCKLVGHTeqgkkcDYCDARNPRRS---HPAENLtdgNNPNNPTWWQS---EPLSNGPQNVNLTLDLGK-EFHVT 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 384 YIIIQFFSPQPTEIRIQRKKENSlDWEDWQYFARNCGA-FGMKNNGDLEKP--DSVNCL-QLSNFTPYSRGNVTFSILTP 459
Cdd:smart00136 102 YVILKFCSPRPSLWILERSDFGK-TWQPWQYFSSDCRRtFGRPPRGPITKGneDEVICTsEYSDIVPLEGGEIAFSLLEG 180
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1796365450 460 gpnyRPGYNNFYNTPSLQEFVKATQIRFHFH-----GQYYTTETAVNLRHRYYAVDEITISG 516
Cdd:smart00136 181 ----RPSATDFDNSPVLQEWVTATNIRVRLTrlrtlGDELMDDRPEVTRRYYYAISDIAVGG 238
|
|
| Laminin_G_1 |
pfam00054 |
Laminin G domain; |
1548-1678 |
4.72e-21 |
|
Laminin G domain;
Pssm-ID: 395008 [Multi-domain] Cd Length: 131 Bit Score: 91.99 E-value: 4.72e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1548 FRTKVPEGLIVFAASPgNQEEYFALQLKKGRLYFLFDPqGSPVEVTTtndHGKQYSDGKWHEIIAIRHQAFGQITLDGIY 1627
Cdd:pfam00054 1 FRTTEPSGLLLYNGTQ-TERDFLALELRDGRLEVSYDL-GSGAAVVR---SGDKLNDGKWHSVELERNGRSGTLSVDGEA 75
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 1796365450 1628 TGSSAILNGSTVIGD-NTGVFLGGLPRSYTILRKDPeiIQKGFVGCLKDVHF 1678
Cdd:pfam00054 76 RPTGESPLGATTDLDvDGPLYVGGLPSLGVKKRRLA--ISPSFDGCIRDVIV 125
|
|
| LamG |
smart00282 |
Laminin G domain; |
1739-1868 |
9.06e-21 |
|
Laminin G domain;
Pssm-ID: 214598 [Multi-domain] Cd Length: 132 Bit Score: 91.25 E-value: 9.06e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1739 EISFKFRTDQLNGLLLFVYNKDGPDFLAMELKSG--ILTFRLNTSLAFTQVDlllGLSYCNGKWNKVIIKKEGSFISASV 1816
Cdd:smart00282 1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGrlVLRYDLGSGPARLTSD---PTPLNDGQWHRVAVERNGRSVTLSV 77
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1796365450 1817 NGLMKHASES--GDQPLVVNSPVYVGGIPQELLNSyqHLCLEQGFGGCMKDVKF 1868
Cdd:smart00282 78 DGGNRVSGESpgGLTILNLDGPLYLGGLPEDLKLP--PLPVTPGFRGCIRNLKV 129
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
4342-4765 |
5.79e-18 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 91.60 E-value: 5.79e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4342 STSKPTSITTLEAAPSEVSPPDLWAVSATQMNVCWSPPTVQNGKITKYLVRydnkeSLAGQGLCLLVSHLQPYSQYNFSL 4421
Cdd:COG3401 51 SPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSG-----SVGGATNTGLTSSDEVPSPAVGTA 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4422 VACTNGGCTASVSKSAWTMEALPENMDSPTLQVTGSESIEITWKPPRNPNGQIRSYelrrDGTIVYTGLETRYRDFTLTP 4501
Cdd:COG3401 126 TTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVA----TTSLTVTSTTLVDGGGDIEP 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4502 GVEYSYTVTASNSQG-GILSPLV---KDRTSPSAPSGMeppKLQARGPQEILVNWDPPvrTNGDIINYTLFIRElfERET 4577
Cdd:COG3401 202 GTTYYYRVAATDTGGeSAPSNEVsvtTPTTPPSAPTGL---TATADTPGSVTLSWDPV--TESDATGYRVYRSN--SGDG 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4578 KIIHINTTHNSfgmqSYIVNQLKPFHRYEIRIQACTTLGCAS--SDWTFIQTPEIAPlmQPPPHLEVQMAPGGfqpTVSL 4655
Cdd:COG3401 275 PFTKVATVTTT----SYTDTGLTNGTTYYYRVTAVDAAGNESapSNVVSVTTDLTPP--AAPSGLTATAVGSS---SITL 345
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4656 LWTGPlqPNGKVLYYELYRrqiATQPRKSNPVLIYNGSSTSFIDSELLPFTEYEYQVWAVNSAGK--APS------SWTW 4727
Cdd:COG3401 346 SWTAS--SDADVTGYNVYR---STSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNesAPSeevsatTASA 420
|
410 420 430
....*....|....*....|....*....|....*...
gi 1796365450 4728 CRTGPAPPEGLRAPTFHVISSTQAVVNISAPGKPNGIV 4765
Cdd:COG3401 421 ASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVL 458
|
|
| Laminin_G_2 |
pfam02210 |
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ... |
1744-1868 |
9.61e-18 |
|
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.
Pssm-ID: 460494 [Multi-domain] Cd Length: 126 Bit Score: 82.47 E-value: 9.61e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1744 FRTDQLNGLLLFVyNKDGPDFLAMELKSGILTFRLNTSLAfTQVDLLLGLSYCNGKWNKVIIKKEGSFISASVNGLMKHA 1823
Cdd:pfam02210 1 FRTRQPNGLLLYA-GGGGSDFLALELVNGRLVLRYDLGSG-PESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVS 78
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 1796365450 1824 S--ESGDQPLVVNSPVYVGGIPQELLNSYQHlcLEQGFGGCMKDVKF 1868
Cdd:pfam02210 79 SlpPGESLLLNLNGPLYLGGLPPLLLLPALP--VRAGFVGCIRDVRV 123
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
3450-3846 |
5.81e-17 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 88.52 E-value: 5.81e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 3450 TIHTGSVNTYSYTDVNLKPYMTYEYRISAWNSYGRG-LSKAVRARTKEDVPqgvSPPTWTKIDNLEDTIV-LNWRKPiqS 3527
Cdd:COG3401 183 TSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESaPSNEVSVTTPTTPP---SAPTGLTATADTPGSVtLSWDPV--T 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 3528 NGPIIYYILLR--NGIERF----RGTSLSFSDKeGIQPFQEYSYQLKACTVAGC-ATSSKVVAATTQGVPesilPPSITA 3600
Cdd:COG3401 258 ESDATGYRVYRsnSGDGPFtkvaTVTTTSYTDT-GLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTP----PAAPSG 332
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 3601 LSAVA-----LHLSWSvpEKSNGVIKEYQI-RQVGKG----LIHTDTTDrRQHTVTGLQPYTNYSFTLTACTSAGCTS-- 3668
Cdd:COG3401 333 LTATAvgsssITLSWT--ASSDADVTGYNVyRSTSGGgtytKIAETVTT-TSYTDTGLTPGTTYYYKVTAVDAAGNESap 409
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 3669 SEPFLGQTLQAAP-----EGVWVTPRHIIINSTTVELYWSLPEKPNGLVSQYQLSRNGNLLFLGGSEEQNFTDKNLEPNS 3743
Cdd:COG3401 410 SEEVSATTASAASgesltASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANL 489
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 3744 RYTYKLEVKTGGGSSASDDYIVQTPMSTPEEIYPPYNITVIGPYSI-FVAWIPPGILIPEIPVEYNVLLNDGSVTPLAFS 3822
Cdd:COG3401 490 SVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASPvTVGASTGDVLITDLVSLTTSASSSVSGAGLGSG 569
|
410 420
....*....|....*....|....*.
gi 1796365450 3823 VGHHQSTLLENLTP--FTQYEIRIQA 3846
Cdd:COG3401 570 NLYLITTLGGSLLTttSTNTNDVAGV 595
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
2685-3074 |
1.13e-14 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 81.20 E-value: 1.13e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2685 DKTSALSPWTKYEYRVLMSTLHGGTNSSAWVEVT---TRPSRPAGVQppvVTVLEPDAVQVTWKPPliQNGDILSYEIH- 2760
Cdd:COG3401 194 DGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTtptTPPSAPTGLT---ATADTPGSVTLSWDPV--TESDATGYRVYr 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2761 --MPDPH---ITLTNVTSAVlsqkVTHLIPFTNYSVTIVAcSGGNGYLGGCTESLptYVTTHPTVPQNVGPLSVIPLSES 2835
Cdd:COG3401 269 snSGDGPftkVATVTTTSYT----DTGLTNGTTYYYRVTA-VDAAGNESAPSNVV--SVTTDLTPPAAPSGLTATAVGSS 341
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2836 YVVISWQPPSkpnGPNL-RYELLRRKIqqplASNPPEDLNRwhnIYSGTQwlYEDKGLSRFTTYEYMLFVHNSVGFT--P 2912
Cdd:COG3401 342 SITLSWTASS---DADVtGYNVYRSTS----GGGTYTKIAE---TVTTTS--YTDTGLTPGTTYYYKVTAVDAAGNEsaP 409
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2913 SREVTVTTLAGLPERGANLTASVLNHTAIDVRWAKPTVQDLQGEVEYYTLFWSSATSNDSLKILPDVNshvighLKPNTE 2992
Cdd:COG3401 410 SEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTV------TATTTD 483
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2993 YWIFISVFNGVHSINSAGLHATTCDGEPQGMLPPEVVIINSTAVRVIWTSP--SNPNGVVTEYSIYVNNKLYKTGMNVPG 3070
Cdd:COG3401 484 TTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASpvTVGASTGDVLITDLVSLTTSASSSVSG 563
|
....
gi 1796365450 3071 SFIL 3074
Cdd:COG3401 564 AGLG 567
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
900-948 |
3.35e-14 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 69.69 E-value: 3.35e-14
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 1796365450 900 CECDSLGTLPGTiCDPISGQCLCVPNRQGRRCNQCQPGFYISPGNATGC 948
Cdd:cd00055 2 CDCNGHGSLSGQ-CDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGGGC 49
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
900-948 |
4.71e-14 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 69.26 E-value: 4.71e-14
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 1796365450 900 CECDSLGTLPGTiCDPISGQCLCVPNRQGRRCNQCQPGFYISPGNatGC 948
Cdd:smart00180 1 CDCDPGGSASGT-CDPDTGQCECKPNVTGRRCDRCAPGYYGDGPP--GC 46
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
900-948 |
5.43e-14 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 68.92 E-value: 5.43e-14
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 1796365450 900 CECDSLGTLPGTiCDPISGQCLCVPNRQGRRCNQCQPGFY-ISPGNATGC 948
Cdd:pfam00053 1 CDCNPHGSLSDT-CDPETGQCLCKPGVTGRHCDRCKPGYYgLPSDPPQGC 49
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
641-691 |
9.85e-14 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 68.15 E-value: 9.85e-14
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 1796365450 641 CDCDTVGTRNGSilCDQIGGQCNCKRHVSGRQCNQCQNGFYNLQELDPDGC 691
Cdd:pfam00053 1 CDCNPHGSLSDT--CDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
|
|
| Laminin_G_1 |
pfam00054 |
Laminin G domain; |
1744-1868 |
1.01e-13 |
|
Laminin G domain;
Pssm-ID: 395008 [Multi-domain] Cd Length: 131 Bit Score: 71.19 E-value: 1.01e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1744 FRTDQLNGLLLFVYNKDGPDFLAMELKSGILTFRLNtsLAFTQVDLLLGLSYCNGKWNKVIIKKEGSFISASVNGLMKHA 1823
Cdd:pfam00054 1 FRTTEPSGLLLYNGTQTERDFLALELRDGRLEVSYD--LGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARPT 78
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1796365450 1824 SES---GDQPLVVNSPVYVGGIPQELLNSYqHLCLEQGFGGCMKDVKF 1868
Cdd:pfam00054 79 GESplgATTDLDVDGPLYVGGLPSLGVKKR-RLAISPSFDGCIRDVIV 125
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
3477-3793 |
1.09e-13 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 77.74 E-value: 1.09e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 3477 SAWNSYGRGLSKAVRARTKEDVPQGVSPPTWTKIDNLEDTIVLNWRKPIQSNGPIIYYILLRNGIERFRGTSLSFS---- 3552
Cdd:COG3401 113 SSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTsttl 192
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 3553 --DKEGIQPFQEYSYQLKACTVAGCATSSKVVAATTQGVPesilPPSITALSAVA-----LHLSWSVPEKSNgvIKEYQI 3625
Cdd:COG3401 193 vdGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTP----PSAPTGLTATAdtpgsVTLSWDPVTESD--ATGYRV 266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 3626 --RQVGKG---LIHTDTTdrRQHTVTGLQPYTNYSFTLTACTSAGCTS--SEP---FLGQTLQAAPEGVWVTprhiIINS 3695
Cdd:COG3401 267 yrSNSGDGpftKVATVTT--TSYTDTGLTNGTTYYYRVTAVDAAGNESapSNVvsvTTDLTPPAAPSGLTAT----AVGS 340
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 3696 TTVELYWSlpEKPNGLVSQYQLSRN----GNLLFLGGSEEQN-FTDKNLEPNSRYTYKLEVKTGGG--SSASDDYIVQTP 3768
Cdd:COG3401 341 SSITLSWT--ASSDADVTGYNVYRStsggGTYTKIAETVTTTsYTDTGLTPGTTYYYKVTAVDAAGneSAPSEEVSATTA 418
|
330 340
....*....|....*....|....*
gi 1796365450 3769 MSTPEEIYPPYNITVIGPYSIFVAW 3793
Cdd:COG3401 419 SAASGESLTASVDAVPLTDVAGATA 443
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
640-691 |
1.73e-13 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 67.76 E-value: 1.73e-13
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 1796365450 640 PCDCDTVGTRNGSilCDQIGGQCNCKRHVSGRQCNQCQNGFYNLQElDPDGC 691
Cdd:cd00055 1 PCDCNGHGSLSGQ--CDPGTGQCECKPNTTGRRCDRCAPGYYGLPS-QGGGC 49
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
950-1000 |
2.18e-13 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 67.38 E-value: 2.18e-13
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 1796365450 950 PCSCHTTGAVNHICNSLTGQCVCQDAsIAGQRCDQCKDHYFGFDPQTGRCQ 1000
Cdd:cd00055 1 PCDCNGHGSLSGQCDPGTGQCECKPN-TTGRRCDRCAPGYYGLPSQGGGCQ 50
|
|
| Laminin_G_3 |
pfam13385 |
Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin ... |
146-285 |
2.89e-13 |
|
Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.
Pssm-ID: 463865 [Multi-domain] Cd Length: 151 Bit Score: 70.49 E-value: 2.89e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 146 ASFTLAVWLKPEQ--QGVMCVIEKTVDGQIVFKLTiSEKETMFYYRTVNGLqpPIKVMTLGRILVKKWIHLSVQVHQTKI 223
Cdd:pfam13385 17 SDFTVSAWVKPDSlpGWARAIISSSGGGGYSLGLD-GDGRLRFAVNGGNGG--WDTVTSGASVPLGQWTHVAVTYDGGTL 93
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1796365450 224 SFFINGVEKDhtpfnARTLSGSITDFASGTVQIGQSLNGLEQFVGRMQDFRLYQVALTNREI 285
Cdd:pfam13385 94 RLYVNGVLVG-----SSTLTGGPPPGTGGPLYIGRSPGGDDYFNGLIDEVRIYDRALSAAEI 150
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
641-691 |
3.77e-13 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 66.57 E-value: 3.77e-13
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 1796365450 641 CDCDTVGTRNGSilCDQIGGQCNCKRHVSGRQCNQCQNGFYNlqeLDPDGC 691
Cdd:smart00180 1 CDCDPGGSASGT--CDPDTGQCECKPNVTGRRCDRCAPGYYG---DGPPGC 46
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
747-795 |
3.79e-13 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 66.61 E-value: 3.79e-13
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 1796365450 747 CQCNLHGSVNKFCNPHSGQCECKKEAKGLQCDTCRENFYGLDVTNCKAC 795
Cdd:pfam00053 1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
746-788 |
7.18e-13 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 65.84 E-value: 7.18e-13
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 1796365450 746 PCQCNLHGSVNKFCNPHSGQCECKKEAKGLQCDTCRENFYGLD 788
Cdd:cd00055 1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLP 43
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
2533-2619 |
1.87e-12 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 65.98 E-value: 1.87e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2533 PGPVVPPILLDVKSRMMLVTWQHPRKSNGVITHYNIYLH------GRLYLRTPGNVTNCTVMHLHPYTAYKFQVEACTSK 2606
Cdd:cd00063 1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYRekgsgdWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80
|
90
....*....|...
gi 1796365450 2607 GCSLSPESQTVWT 2619
Cdd:cd00063 81 GESPPSESVTVTT 93
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
847-897 |
3.56e-12 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 63.87 E-value: 3.56e-12
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 1796365450 847 CNCDKTGTINGSllCNKSTGQCPCKLGVTGLRCNQCEPHRYNltiDNFQHC 897
Cdd:smart00180 1 CDCDPGGSASGT--CDPDTGQCECKPNVTGRRCDRCAPGYYG---DGPPGC 46
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
747-792 |
4.00e-12 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 63.48 E-value: 4.00e-12
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 1796365450 747 CQCNLHGSVNKFCNPHSGQCECKKEAKGLQCDTCRENFYGLDVTNC 792
Cdd:smart00180 1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
794-844 |
4.17e-12 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 63.53 E-value: 4.17e-12
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 1796365450 794 ACDCDTAGSLPGTvCNAKTGQCICKPNVEGRQCNKCLEGnFYLRQNNSFLC 844
Cdd:cd00055 1 PCDCNGHGSLSGQ-CDPGTGQCECKPNTTGRRCDRCAPG-YYGLPSQGGGC 49
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
795-834 |
4.37e-12 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 63.48 E-value: 4.37e-12
10 20 30 40
....*....|....*....|....*....|....*....|
gi 1796365450 795 CDCDTAGSLPGTvCNAKTGQCICKPNVEGRQCNKCLEGNF 834
Cdd:smart00180 1 CDCDPGGSASGT-CDPDTGQCECKPNVTGRRCDRCAPGYY 39
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
4309-4585 |
6.02e-12 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 72.34 E-value: 6.02e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4309 FSFDPVTFNYTDEELLPFSTYSYALQACTSGGCST-SKPTSITTLEAAPSevSPPDLWAVSAT--QMNVCWSPPTVQNgk 4385
Cdd:COG3401 185 LTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESApSNEVSVTTPTTPPS--APTGLTATADTpgSVTLSWDPVTESD-- 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4386 ITKYLVRYDNKES-----LA-GQGLCLLVSHLQPYSQYNFSLVACTNGGCT--ASVSKSAWTMEALPENMDSPTLQVTGS 4457
Cdd:COG3401 261 ATGYRVYRSNSGDgpftkVAtVTTTSYTDTGLTNGTTYYYRVTAVDAAGNEsaPSNVVSVTTDLTPPAAPSGLTATAVGS 340
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4458 ESIEITWKPprNPNGQIRSYELRRDGT-------IVYTGLETRYRDFTLTPGVEYSYTVTASNSQG---------GILSP 4521
Cdd:COG3401 341 SSITLSWTA--SSDADVTGYNVYRSTSgggtytkIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGnesapseevSATTA 418
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1796365450 4522 LVKDRTSPSAPSGMEPPKLQARGPQEILVNWDPPVRTNGDIINYTLFIRELFERETKIIHINTT 4585
Cdd:COG3401 419 SAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTT 482
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
1242-1357 |
7.24e-12 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 64.44 E-value: 7.24e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1242 PPQRLsppKMQKISSTELHVEWSPPAELNGIIIRYELYMRRLRSTKETTSEESRvfqssgwlsphsfvesanenalkPPQ 1321
Cdd:cd00063 3 PPTNL---RVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTP-----------------------GSE 56
|
90 100 110
....*....|....*....|....*....|....*..
gi 1796365450 1322 TMTTITGLEPYTKYEFRVLAVNMAG-SVSSAWVSERT 1357
Cdd:cd00063 57 TSYTLTGLKPGTEYEFRVRAVNGGGeSPPSESVTVTT 93
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
846-898 |
7.34e-12 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 63.14 E-value: 7.34e-12
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1796365450 846 PCNCDKTGTINGSllCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTiDNFQHCQ 898
Cdd:cd00055 1 PCDCNGHGSLSGQ--CDPGTGQCECKPNTTGRRCDRCAPGYYGLP-SQGGGCQ 50
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
3964-4057 |
7.98e-12 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 64.44 E-value: 7.98e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 3964 PPQDfpaPWAQATSAHSVLLNWTKPESPNGIISHYRVVYQERPDDptfnsPTVHAFTVKGTSHQAHLYGLEPFTTYRIGV 4043
Cdd:cd00063 3 PPTN---LRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSG-----DWKEVEVTPGSETSYTLTGLKPGTEYEFRV 74
|
90
....*....|....
gi 1796365450 4044 VAANHAGEilSPWT 4057
Cdd:cd00063 75 RAVNGGGE--SPPS 86
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
1103-1469 |
8.12e-12 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 71.96 E-value: 8.12e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1103 YPYSIQYFLDTDLLPYTKYSYYIETTNVHGSTrsvAVTYKTKPGVPEGNLTLSYIIPIGSDSVTLTWTTLSNQSGPIEKY 1182
Cdd:COG3401 93 GLTTLTGSGSVGGATNTGLTSSDEVPSPAVGT---ATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVV 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1183 IlscAPLAGGQPCVSYEGHETSATIW-----NLVPFAKYDFSVQACTSGGC-LHSLPITVTTAQAPPQRLSPPKMQKISS 1256
Cdd:COG3401 170 V---SPDTSATAAVATTSLTVTSTTLvdgggDIEPGTTYYYRVAATDTGGEsAPSNEVSVTTPTTPPSAPTGLTATADTP 246
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1257 TELHVEWSPPAELNgiIIRYELYmrrlRSTKettseesrvfqssgwlSPHSFVESANENAlkppqTMTTITGLEPYTKYE 1336
Cdd:COG3401 247 GSVTLSWDPVTESD--ATGYRVY----RSNS----------------GDGPFTKVATVTT-----TSYTDTGLTNGTTYY 299
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1337 FRVLAVNMAGSVS--SAWVSERTGESAPvfmIPPSVF---PLSSYSLNISWEKPADNvtrgKVVGYDInmlsEQSPQQSI 1411
Cdd:COG3401 300 YRVTAVDAAGNESapSNVVSVTTDLTPP---AAPSGLtatAVGSSSITLSWTASSDA----DVTGYNV----YRSTSGGG 368
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1796365450 1412 PmaFSQLLHTAKsqELSYTVEGLKPYRIYEFTITLCNSVGCVTSASGAGQTLAAAPAQ 1469
Cdd:COG3401 369 T--YTKIAETVT--TTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAAS 422
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1150-1227 |
9.67e-12 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 63.97 E-value: 9.67e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1150 GNLTlsyIIPIGSDSVTLTWTTLSNQSGPIEKYILSCAPLAGGQPCVSYE--GHETSATIWNLVPFAKYDFSVQACTSGG 1227
Cdd:pfam00041 4 SNLT---VTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITvpGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
951-996 |
1.29e-11 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 62.33 E-value: 1.29e-11
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 1796365450 951 CSCHTTGAVNHICNSLTGQCVCQDAsIAGQRCDQCKDHYFGFDPQT 996
Cdd:smart00180 1 CDCDPGGSASGTCDPDTGQCECKPN-VTGRRCDRCAPGYYGDGPPG 45
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
847-897 |
1.57e-11 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 61.99 E-value: 1.57e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 1796365450 847 CNCDKTGTINGSllCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTIDNFQHC 897
Cdd:pfam00053 1 CDCNPHGSLSDT--CDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
3969-4057 |
1.61e-11 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 63.20 E-value: 1.61e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 3969 PAPW---AQATSAHSVLLNWTKPESPNGIISHYRVVYQERpddptfNSPTVHA-FTVKGTSHQAHLYGLEPFTTYRIGVV 4044
Cdd:pfam00041 1 SAPSnltVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPK------NSGEPWNeITVPGTTTSVTLTGLKPGTEYEVRVQ 74
|
90
....*....|...
gi 1796365450 4045 AANHAGEilSPWT 4057
Cdd:pfam00041 75 AVNGGGE--GPPS 85
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
1145-1238 |
1.92e-11 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 63.28 E-value: 1.92e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1145 PGVPEgNLTLSyiiPIGSDSVTLTWTTLSNQSGPIEKYILSCAPLAGGQP--CVSYEGHETSATIWNLVPFAKYDFSVQA 1222
Cdd:cd00063 1 PSPPT-NLRVT---DVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWkeVEVTPGSETSYTLTGLKPGTEYEFRVRA 76
|
90
....*....|....*..
gi 1796365450 1223 CTSGGC-LHSLPITVTT 1238
Cdd:cd00063 77 VNGGGEsPPSESVTVTT 93
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
2252-2722 |
3.11e-11 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 70.03 E-value: 3.11e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2252 YSPDSFNVSWTEPEYPNGVITSYGLYLDGILIHNSSELSYRAYGFAPWSLHSFRVQAC-----TAKGCALGPLVENRTLE 2326
Cdd:COG3401 42 VVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGsgsvgGATNTGLTSSDEVPSPA 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2327 APPEGTVNVFVKTQGSRKAHVRWEAPFRPNGLLTHSVLFTGIFYVDPVG--NNYTLLNVTKVMYSGEETNLWVLIDGLVP 2404
Cdd:COG3401 122 VGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVspDTSATAAVATTSLTVTSTTLVDGGGDIEP 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2405 FTNYTVQVNISN----SQGSLITDPITIAMPPGAPDGVlppRLSSATPTSLQVVWSTPARNNAPGsprYQLQmRSGDSTH 2480
Cdd:COG3401 202 GTTYYYRVAATDtggeSAPSNEVSVTTPTTPPSAPTGL---TATADTPGSVTLSWDPVTESDATG---YRVY-RSNSGDG 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2481 GFLELfsNPSASLSYEVSDLQPYTEYMFRLVASNGFG--SAHSSwipfmTAEDKPGPVVPPILLDVKSRMML-----VTW 2553
Cdd:COG3401 275 PFTKV--ATVTTTSYTDTGLTNGTTYYYRVTAVDAAGneSAPSN-----VVSVTTDLTPPAAPSGLTATAVGsssitLSW 347
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2554 QHPrkSNGVITHYNIY---LHGRLYLR--TPGNVTNCTVMHLHPYTAYKFQVEACTSKGCSLSPESQTVWTLPGAPEGIP 2628
Cdd:COG3401 348 TAS--SDADVTGYNVYrstSGGGTYTKiaETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAASGES 425
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2629 SPELFSDTPTSVIISWQPPTHPNGLVENFTIERRVKGKEEVTTLVTLPRSHSMRFIDKTSALSPWTKYEYRVLMSTLHGG 2708
Cdd:COG3401 426 LTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSV 505
|
490
....*....|....
gi 1796365450 2709 TNSSAWVEVTTRPS 2722
Cdd:COG3401 506 TNSVSVIGASAAAA 519
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
2432-2528 |
3.83e-11 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 62.51 E-value: 3.83e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2432 PGAPDGVlppRLSSATPTSLQVVWSTPARNNAPGSpRYQLQMRSGDSThGFLELFSNPSASLSYEVSDLQPYTEYMFRLV 2511
Cdd:cd00063 1 PSPPTNL---RVTDVTSTSVTLSWTPPEDDGGPIT-GYVVEYREKGSG-DWKEVEVTPGSETSYTLTGLKPGTEYEFRVR 75
|
90
....*....|....*...
gi 1796365450 2512 ASNGFG-SAHSSWIPFMT 2528
Cdd:cd00063 76 AVNGGGeSPPSESVTVTT 93
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
795-849 |
4.08e-11 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 60.83 E-value: 4.08e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 1796365450 795 CDCDTAGSLPGTvCNAKTGQCICKPNVEGRQCNKCLEGnFYLRQNNSflclPCNC 849
Cdd:pfam00053 1 CDCNPHGSLSDT-CDPETGQCLCKPGVTGRHCDRCKPG-YYGLPSDP----PQGC 49
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
2621-2719 |
6.18e-11 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 61.74 E-value: 6.18e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2621 PGAPEGIpspELFSDTPTSVIISWQPPTHPNGLVENFTIERRVKGKEEVTTL-VTLPRSHSMRFIDktsaLSPWTKYEYR 2699
Cdd:cd00063 1 PSPPTNL---RVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVeVTPGSETSYTLTG----LKPGTEYEFR 73
|
90 100
....*....|....*....|
gi 1796365450 2700 VLMSTLHGGTNSSAWVEVTT 2719
Cdd:cd00063 74 VRAVNGGGESPPSESVTVTT 93
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
951-1004 |
7.34e-11 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 60.06 E-value: 7.34e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 1796365450 951 CSCHTTGAVNHICNSLTGQCVCQDaSIAGQRCDQCKDHYFGFDPqtgrCQPCNC 1004
Cdd:pfam00053 1 CDCNPHGSLSDTCDPETGQCLCKP-GVTGRHCDRCKPGYYGLPS----DPPQGC 49
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
694-733 |
1.08e-10 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 59.63 E-value: 1.08e-10
10 20 30 40
....*....|....*....|....*....|....*....|
gi 1796365450 694 CNCNTSGTVDGdiTCHQNSGQCKCKANVIGLRCDHCNFGF 733
Cdd:smart00180 1 CDCDPGGSASG--TCDPDTGQCECKPNVTGRRCDRCAPGY 38
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
4826-4927 |
1.09e-10 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 60.97 E-value: 1.09e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4826 PAPPSGLsspQIGTLASRTASFRWSPPMFPNGVIHSYELQFHvACPPDSALPCTPSQI-ETKYTglgqkasLGGLQPYTT 4904
Cdd:cd00063 1 PSPPTNL---RVTDVTSTSVTLSWTPPEDDGGPITGYVVEYR-EKGSGDWKEVEVTPGsETSYT-------LTGLKPGTE 69
|
90 100
....*....|....*....|....
gi 1796365450 4905 YKLRVVAHNEVG-STASEWISFTT 4927
Cdd:cd00063 70 YEFRVRAVNGGGeSPPSESVTVTT 93
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
1051-1243 |
1.13e-10 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 68.11 E-value: 1.13e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1051 SKTPFQQPPP-----RGQVQSSSAINLSWSPPDSPNAhwltysllrDGFEIY-TTEDQYPYSI------QYFLDTDLLPY 1118
Cdd:COG3401 225 SVTTPTTPPSaptglTATADTPGSVTLSWDPVTESDA---------TGYRVYrSNSGDGPFTKvatvttTSYTDTGLTNG 295
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1119 TKYSYYIETTNVHG--STRSVAV---TYKTKPGVPEgNLTLSYiipIGSDSVTLTWTtlSNQSGPIEKYILSCAPLAGGQ 1193
Cdd:COG3401 296 TTYYYRVTAVDAAGneSAPSNVVsvtTDLTPPAAPS-GLTATA---VGSSSITLSWT--ASSDADVTGYNVYRSTSGGGT 369
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1796365450 1194 PCVSYEGH-ETSATIWNLVPFAKYDFSVQACTSGGC--LHSLPITVTTAQAPP 1243
Cdd:COG3401 370 YTKIAETVtTTSYTDTGLTPGTTYYYKVTAVDAAGNesAPSEEVSATTASAAS 422
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
693-745 |
1.16e-10 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 59.68 E-value: 1.16e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1796365450 693 PCNCNTSGTVDGdiTCHQNSGQCKCKANVIGLRCDHCNFGFkFLRSFNDVGCE 745
Cdd:cd00055 1 PCDCNGHGSLSG--QCDPGTGQCECKPNTTGRRCDRCAPGY-YGLPSQGGGCQ 50
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
1001-1037 |
1.56e-10 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 59.29 E-value: 1.56e-10
10 20 30
....*....|....*....|....*....|....*..
gi 1796365450 1001 PCNCHLSGALNETCHLVTGQCFCKQFVTGSKCDACVP 1037
Cdd:cd00055 1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAP 37
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
4592-4807 |
2.65e-10 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 66.95 E-value: 2.65e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4592 QSYIVNQLKPFHRYEIRIQACTTLGCASSDWTFIQTPEIAPLMqPPPHLEVQMAPGGfqpTVSLLWTGPlqPNGKVLYYE 4671
Cdd:COG3401 192 LVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPS-APTGLTATADTPG---SVTLSWDPV--TESDATGYR 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4672 LYRRQIATQPrksnPVLIYNGSSTSFIDSELLPFTEYEYQVWAVNSAGK--APS---SWTWCRTGPAPPEGLRAPtfhVI 4746
Cdd:COG3401 266 VYRSNSGDGP----FTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNesAPSnvvSVTTDLTPPAAPSGLTAT---AV 338
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1796365450 4747 SSTQAVVNISAPgkPNGIVSLYRLFSSSAHG--AETVLSEGMATQQTLHGLQAFTNYSIGVEA 4807
Cdd:COG3401 339 GSSSITLSWTAS--SDADVTGYNVYRSTSGGgtYTKIAETVTTTSYTDTGLTPGTTYYYKVTA 399
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
694-749 |
2.94e-10 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 58.52 E-value: 2.94e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 1796365450 694 CNCNTSGTVDGdiTCHQNSGQCKCKANVIGLRCDHCNFGFkflrsFNDVGCEPCQC 749
Cdd:pfam00053 1 CDCNPHGSLSD--TCDPETGQCLCKPGVTGRHCDRCKPGY-----YGLPSDPPQGC 49
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1242-1346 |
3.98e-10 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 59.35 E-value: 3.98e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1242 PPQRLSppkMQKISSTELHVEWSPPAELNGIIIRYELymrrlrsTKETTSEESRVFQSSgwlsphsfvesanenaLKPPQ 1321
Cdd:pfam00041 2 APSNLT---VTDVTSTSLTVSWTPPPDGNGPITGYEV-------EYRPKNSGEPWNEIT----------------VPGTT 55
|
90 100
....*....|....*....|....*
gi 1796365450 1322 TMTTITGLEPYTKYEFRVLAVNMAG 1346
Cdd:pfam00041 56 TSVTLTGLKPGTEYEVRVQAVNGGG 80
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
4529-4627 |
4.69e-10 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 59.43 E-value: 4.69e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4529 PSAPSGmepPKLQARGPQEILVNWDPPVRTNGDIINYTLFIRELFERETKIIHINTTHNSfgmqSYIVNQLKPFHRYEIR 4608
Cdd:cd00063 1 PSPPTN---LRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSET----SYTLTGLKPGTEYEFR 73
|
90 100
....*....|....*....|
gi 1796365450 4609 IQACTTLGC-ASSDWTFIQT 4627
Cdd:cd00063 74 VRAVNGGGEsPPSESVTVTT 93
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
1002-1037 |
1.40e-09 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 56.55 E-value: 1.40e-09
10 20 30
....*....|....*....|....*....|....*.
gi 1796365450 1002 CNCHLSGALNETCHLVTGQCFCKQFVTGSKCDACVP 1037
Cdd:smart00180 1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAP 36
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
1002-1037 |
1.45e-09 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 56.59 E-value: 1.45e-09
10 20 30
....*....|....*....|....*....|....*.
gi 1796365450 1002 CNCHLSGALNETCHLVTGQCFCKQFVTGSKCDACVP 1037
Cdd:pfam00053 1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKP 36
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
3866-3960 |
1.72e-09 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 57.89 E-value: 1.72e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 3866 APMDLNspvLKALGSACIEIKWMPPEKPNGIIINYFIYRRPAGIEEESVLFVWSEGALEFMDEGdtLRPFTLYEYRVRAC 3945
Cdd:cd00063 3 PPTNLR---VTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTG--LKPGTEYEFRVRAV 77
|
90
....*....|....*
gi 1796365450 3946 NSKGsvESLWSLTQT 3960
Cdd:cd00063 78 NGGG--ESPPSESVT 90
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
3927-4190 |
1.74e-09 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 64.25 E-value: 1.74e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 3927 DEGDTLRPFTLYEYRVRACNSKG----SVESLWSLTQTLEAPPQDFPapwAQATSAHSVLLNWTKPESPNgiISHYRvVY 4002
Cdd:COG3401 194 DGGGDIEPGTTYYYRVAATDTGGesapSNEVSVTTPTTPPSAPTGLT---ATADTPGSVTLSWDPVTESD--ATGYR-VY 267
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4003 QERPDDPTFNSPTvhafTVKGTSHQAHlyGLEPFTTYRIGVVAANHAGEIlSPW------TLIQTLESSPSGLRNfiveQ 4076
Cdd:COG3401 268 RSNSGDGPFTKVA----TVTTTSYTDT--GLTNGTTYYYRVTAVDAAGNE-SAPsnvvsvTTDLTPPAAPSGLTA----T 336
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4077 KENGRALLLQWSEPmrTNGVIKTYNIFSDGFLE--YSGLNR-----QFLFRRLDPFTLYTLTLEACTRAGC--AHSAPQP 4147
Cdd:COG3401 337 AVGSSSITLSWTAS--SDADVTGYNVYRSTSGGgtYTKIAEtvtttSYTDTGLTPGTTYYYKVTAVDAAGNesAPSEEVS 414
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 1796365450 4148 LWTDEAPPDSQL-----APTVHSVKSTSVELSWSEPVNPNGKIIRYEV 4190
Cdd:COG3401 415 ATTASAASGESLtasvdAVPLTDVAGATAAASAASNPGVSAAVLADGG 462
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
3590-3676 |
2.07e-09 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 57.51 E-value: 2.07e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 3590 PESILPPSITALSAVALHLSWSVPEKSNGVIKEYQIRQVGKGL-----IHTDTTDRRQHTVTGLQPYTNYSFTLTACTSA 3664
Cdd:cd00063 1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSgdwkeVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80
|
90
....*....|...
gi 1796365450 3665 GC-TSSEPFLGQT 3676
Cdd:cd00063 81 GEsPPSESVTVTT 93
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
3596-3665 |
2.35e-09 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 57.04 E-value: 2.35e-09
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1796365450 3596 PSITALSAVALHLSWSVPEKSNGVIKEYQI--RQVGKGLIHTDTT---DRRQHTVTGLQPYTNYSFTLTACTSAG 3665
Cdd:pfam00041 6 LTVTDVTSTSLTVSWTPPPDGNGPITGYEVeyRPKNSGEPWNEITvpgTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
4636-4730 |
2.71e-09 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 57.12 E-value: 2.71e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4636 PPPHLEVQMAPGGfqpTVSLLWTGPLQPNGKVLYYELYRRQiaTQPRKSNPVLIYNGSSTSFIDSELLPFTEYEYQVWAV 4715
Cdd:cd00063 3 PPTNLRVTDVTST---SVTLSWTPPEDDGGPITGYVVEYRE--KGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAV 77
|
90
....*....|....*.
gi 1796365450 4716 NSAGK-APSSWTWCRT 4730
Cdd:cd00063 78 NGGGEsPPSESVTVTT 93
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
2724-2799 |
2.77e-09 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 57.12 E-value: 2.77e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2724 PAGVQPPVVTVLEPDAVQVTWKPPLIQNGDILSYEIHM----PDPHITLTNVTSAVLSQKVTHLIPFTNYSVTIVACSGG 2799
Cdd:cd00063 1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYrekgSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
2441-2522 |
4.48e-09 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 56.27 E-value: 4.48e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2441 PRLSSATPTSLQVVWSTPARNNAPGSpRYQLQMRSGDSTHGFLElFSNPSASLSYEVSDLQPYTEYMFRLVASNGFGSAH 2520
Cdd:pfam00041 6 LTVTDVTSTSLTVSWTPPPDGNGPIT-GYEVEYRPKNSGEPWNE-ITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGP 83
|
..
gi 1796365450 2521 SS 2522
Cdd:pfam00041 84 PS 85
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
1242-1347 |
4.57e-09 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 56.08 E-value: 4.57e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1242 PPQRLsppKMQKISSTELHVEWSPPAELNGI--IIRYELYMRRLRSTKETTSEesrvfqssgwlsphsfvesanenalKP 1319
Cdd:smart00060 3 PPSNL---RVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYREEGSEWKEVNV-------------------------TP 54
|
90 100
....*....|....*....|....*...
gi 1796365450 1320 PQTMTTITGLEPYTKYEFRVLAVNMAGS 1347
Cdd:smart00060 55 SSTSYTLTGLKPGTEYEFRVRAVNGAGE 82
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
2435-2518 |
5.78e-09 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 56.08 E-value: 5.78e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2435 PDGVLPPRLSSATPTSLQVVWSTPARNNaPGSPRYQLQMRSGDSTHGFLELFSNPSaSLSYEVSDLQPYTEYMFRLVASN 2514
Cdd:smart00060 1 PSPPSNLRVTDVTSTSVTLSWEPPPDDG-ITGYIVGYRVEYREEGSEWKEVNVTPS-STSYTLTGLKPGTEYEFRVRAVN 78
|
....
gi 1796365450 2515 GFGS 2518
Cdd:smart00060 79 GAGE 82
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
1368-1451 |
6.96e-09 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 55.70 E-value: 6.96e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1368 PSVFPLSSYSLNISWEKPADNVTRGKVVGYDINMLSEQSPQQSIpmafsqllhTAKSQELSYTVEGLKPYRIYEFTITLC 1447
Cdd:smart00060 7 LRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEV---------NVTPSSTSYTLTGLKPGTEYEFRVRAV 77
|
....
gi 1796365450 1448 NSVG 1451
Cdd:smart00060 78 NGAG 81
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
2727-2799 |
1.11e-08 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 55.11 E-value: 1.11e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2727 VQPPVVTVLEPDAVQVTWKPPLIQNGDILSYEIH-------MPDPHITLTNVTSAVlsqKVTHLIPFTNYSVTIVACSGG 2799
Cdd:pfam00041 3 PSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEyrpknsgEPWNEITVPGTTTSV---TLTGLKPGTEYEVRVQAVNGG 79
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
3964-4051 |
1.38e-08 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 54.93 E-value: 1.38e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 3964 PPQDfpaPWAQATSAHSVLLNWTKPESPNGI--ISHYRVVYQErpddptfNSPTVHAFTVKGTSHQAHLYGLEPFTTYRI 4041
Cdd:smart00060 3 PPSN---LRVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYRE-------EGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
|
90
....*....|
gi 1796365450 4042 GVVAANHAGE 4051
Cdd:smart00060 73 RVRAVNGAGE 82
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
2534-2614 |
1.42e-08 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 54.73 E-value: 1.42e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2534 GPVVPPILLDVKSRMMLVTWQHPRKSNGVITHYNIYL------HGRLYLRTPGNVTNCTVMHLHPYTAYKFQVEACTSKG 2607
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYrpknsgEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
....*..
gi 1796365450 2608 CslSPES 2614
Cdd:pfam00041 81 E--GPPS 85
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
1145-1227 |
3.63e-08 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 53.77 E-value: 3.63e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1145 PGVPEgNLTLSyiiPIGSDSVTLTWT--TLSNQSGPIEKYILSCAPLAGGQPCVSYEGHETSATIWNLVPFAKYDFSVQA 1222
Cdd:smart00060 1 PSPPS-NLRVT---DVTSTSVTLSWEppPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
|
....*
gi 1796365450 1223 CTSGG 1227
Cdd:smart00060 77 VNGAG 81
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
2533-2609 |
6.39e-08 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 53.00 E-value: 6.39e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2533 PGPVVPPILLDVKSRMMLVTWQHPRKSNGV--ITHYNIYLHGRLY----LRTPGNVTNCTVMHLHPYTAYKFQVEACTSK 2606
Cdd:smart00060 1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYREEGSewkeVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80
|
...
gi 1796365450 2607 GCS 2609
Cdd:smart00060 81 GEG 83
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
2636-2700 |
7.17e-08 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 52.80 E-value: 7.17e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1796365450 2636 TPTSVIISWQPPTHPNGLVENFTIERRVKGKEEVTTLVTLPRS-HSMRFidktSALSPWTKYEYRV 2700
Cdd:pfam00041 12 TSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITVPGTtTSVTL----TGLKPGTEYEVRV 73
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
3735-4027 |
8.98e-08 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 58.86 E-value: 8.98e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 3735 TDKNLEPNSRYTYKLEVKTGGGSSASDDYIVQTPMSTPEEiyPPYNITV--IGPYSIFVAWIPPgiliPEIPVE-YNVLL 3811
Cdd:COG3401 195 GGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPS--APTGLTAtaDTPGSVTLSWDPV----TESDATgYRVYR 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 3812 ---NDGSVTPLAFSVGhhQSTLLENLTPFTQYEIRIQA--CQNGSCGVSSRMFVKTPEAAPmdlNSPV-LKA--LGSACI 3883
Cdd:COG3401 269 snsGDGPFTKVATVTT--TSYTDTGLTNGTTYYYRVTAvdAAGNESAPSNVVSVTTDLTPP---AAPSgLTAtaVGSSSI 343
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 3884 EIKWMPPekPNGIIINYFIYRRPAGIEEESVLFVwSEGALEFMDEGdtLRPFTLYEYRVRACNSKGsVESLWS----LTQ 3959
Cdd:COG3401 344 TLSWTAS--SDADVTGYNVYRSTSGGGTYTKIAE-TVTTTSYTDTG--LTPGTTYYYKVTAVDAAG-NESAPSeevsATT 417
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 3960 TLEAPPQDFPAPWAQATSAHSVLLNW-TKPESPNGIISH-YRVVYQERPDDPTFNSPTVHAFTVKGTSHQ 4027
Cdd:COG3401 418 ASAASGESLTASVDAVPLTDVAGATAaASAASNPGVSAAvLADGGDTGNAVPFTTTSSTVTATTTDTTTA 487
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
2818-2920 |
1.10e-07 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 52.50 E-value: 1.10e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2818 PTVPQNvgpLSVIPLSESYVVISWQPPSKPNGPNLRYELLRRkiqqplasnpPEDLNRWHNI----YSGTQwlYEDKGLS 2893
Cdd:cd00063 1 PSPPTN---LRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYR----------EKGSGDWKEVevtpGSETS--YTLTGLK 65
|
90 100
....*....|....*....|....*...
gi 1796365450 2894 RFTTYEYMLFVHNSVGF-TPSREVTVTT 2920
Cdd:cd00063 66 PGTEYEFRVRAVNGGGEsPPSESVTVTT 93
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
4357-4428 |
1.17e-07 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 52.42 E-value: 1.17e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4357 SEVSPPDLWAVSATQMNVCWSPPTVQNGKITKYLVRY--------DNKESLAGQGLCLLVSHLQPYSQYNFSLVACTNGG 4428
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYrpknsgepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
4356-4439 |
1.21e-07 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 52.50 E-value: 1.21e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4356 PSEVSPPDLWAVSATQMNVCWSPPTVQNGKITKYLVRYDNK--------ESLAGQGLCLLVSHLQPYSQYNFSLVACTNG 4427
Cdd:cd00063 1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKgsgdwkevEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80
|
90
....*....|...
gi 1796365450 4428 GC-TASVSKSAWT 4439
Cdd:cd00063 81 GEsPPSESVTVTT 93
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
4529-4616 |
1.30e-07 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 52.23 E-value: 1.30e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4529 PSAPSGmepPKLQARGPQEILVNWDPPVRTNGD--IINYTLFIRELFERETKIIHINTTHnsfgmqSYIVNQLKPFHRYE 4606
Cdd:smart00060 1 PSPPSN---LRVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYREEGSEWKEVNVTPSST------SYTLTGLKPGTEYE 71
|
90
....*....|
gi 1796365450 4607 IRIQACTTLG 4616
Cdd:smart00060 72 FRVRAVNGAG 81
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
3590-3665 |
1.73e-07 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 51.85 E-value: 1.73e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 3590 PESILPPSITALSAVALHLSWSVPEKSNGV--IKEYQIRQVGKG---LIHTDTTDRRQHTVTGLQPYTNYSFTLTACTSA 3664
Cdd:smart00060 1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYREEGsewKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80
|
.
gi 1796365450 3665 G 3665
Cdd:smart00060 81 G 81
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
4444-4516 |
3.08e-07 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 51.34 E-value: 3.08e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4444 PENMDSPTLQVTGSESIEITWKPPRNPNGQIRSYELRRDGTI--------VYTGLETRYRDFTLTPGVEYSYTVTASNSQ 4515
Cdd:cd00063 1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGsgdwkeveVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80
|
.
gi 1796365450 4516 G 4516
Cdd:cd00063 81 G 81
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
4530-4616 |
3.29e-07 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 50.88 E-value: 3.29e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4530 SAPSGmepPKLQARGPQEILVNWDPPVRTNGDIINYTLFIRELfERETKIIHINTTHNSFgmqSYIVNQLKPFHRYEIRI 4609
Cdd:pfam00041 1 SAPSN---LTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPK-NSGEPWNEITVPGTTT---SVTLTGLKPGTEYEVRV 73
|
....*..
gi 1796365450 4610 QACTTLG 4616
Cdd:pfam00041 74 QAVNGGG 80
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
4826-4917 |
3.30e-07 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 51.08 E-value: 3.30e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4826 PAPPSGLsspQIGTLASRTASFRWSPPMFPNGviHSYELQFHVACPPDSA--LPCTPSQIETKYTglgqkasLGGLQPYT 4903
Cdd:smart00060 1 PSPPSNL---RVTDVTSTSVTLSWEPPPDDGI--TGYIVGYRVEYREEGSewKEVNVTPSSTSYT-------LTGLKPGT 68
|
90
....*....|....
gi 1796365450 4904 TYKLRVVAHNEVGS 4917
Cdd:smart00060 69 EYEFRVRAVNGAGE 82
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
2724-2799 |
4.13e-07 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 50.69 E-value: 4.13e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2724 PAGVQPPVVTVLEPDAVQVTWKPPLIQNGD--ILSYEIHMPDPHITLT--NVTSAVLSQKVTHLIPFTNYSVTIVACSGG 2799
Cdd:smart00060 1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYREEGSEWKevNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
4161-4247 |
4.24e-07 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 50.49 E-value: 4.24e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4161 PTVHSVKSTSVELSWSEPVNPNGKIIRYEVIRRcfegkawgnqtiQADEKIVFTEYNTERNTFMYNDTGLQPWTQCEYKI 4240
Cdd:pfam00041 6 LTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYR------------PKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRV 73
|
....*..
gi 1796365450 4241 YTWNSAG 4247
Cdd:pfam00041 74 QAVNGGG 80
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
4636-4719 |
4.56e-07 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 50.69 E-value: 4.56e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4636 PPPHLEVQMAPGGfqpTVSLLWTGPLQPN--GKVLYYELYRRQIATQPRKSNPvliyNGSSTSFIDSELLPFTEYEYQVW 4713
Cdd:smart00060 3 PPSNLRVTDVTST---SVTLSWEPPPDDGitGYIVGYRVEYREEGSEWKEVNV----TPSSTSYTLTGLKPGTEYEFRVR 75
|
....*.
gi 1796365450 4714 AVNSAG 4719
Cdd:smart00060 76 AVNGAG 81
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
2621-2707 |
6.42e-07 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 50.31 E-value: 6.42e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2621 PGAPEGIpspELFSDTPTSVIISWQPPTHPNGlvENFTIERRVKGKEEVTTLVTLPRSHSMRFIDKTSaLSPWTKYEYRV 2700
Cdd:smart00060 1 PSPPSNL---RVTDVTSTSVTLSWEPPPDDGI--TGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTG-LKPGTEYEFRV 74
|
....*..
gi 1796365450 2701 LMSTLHG 2707
Cdd:smart00060 75 RAVNGAG 81
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
4828-4916 |
6.52e-07 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 50.11 E-value: 6.52e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4828 PPSGLSSPQIGtlaSRTASFRWSPPMFPNGVIHSYELQFHVACPPDSALPCTPSQIETKYTglgqkasLGGLQPYTTYKL 4907
Cdd:pfam00041 2 APSNLTVTDVT---STSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVT-------LTGLKPGTEYEV 71
|
....*....
gi 1796365450 4908 RVVAHNEVG 4916
Cdd:pfam00041 72 RVQAVNGGG 80
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1368-1451 |
6.71e-07 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 50.11 E-value: 6.71e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1368 PSVFPLSSYSLNISWEKPADNvtRGKVVGYDI--NMLSEQSPQQSIpmafsqllhTAKSQELSYTVEGLKPYRIYEFTIT 1445
Cdd:pfam00041 6 LTVTDVTSTSLTVSWTPPPDG--NGPITGYEVeyRPKNSGEPWNEI---------TVPGTTTSVTLTGLKPGTEYEVRVQ 74
|
....*.
gi 1796365450 1446 LCNSVG 1451
Cdd:pfam00041 75 AVNGGG 80
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
2925-3015 |
7.12e-07 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 50.19 E-value: 7.12e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2925 PERGANLTASVLNHTAIDVRWAKPTvqDLQGEVEYYTLFWSSATSNDSLKI---LPDVNSHVIGHLKPNTEYWIFISVFN 3001
Cdd:cd00063 1 PSPPTNLRVTDVTSTSVTLSWTPPE--DDGGPITGYVVEYREKGSGDWKEVevtPGSETSYTLTGLKPGTEYEFRVRAVN 78
|
90
....*....|....*
gi 1796365450 3002 GVH-SINSAGLHATT 3015
Cdd:cd00063 79 GGGeSPPSESVTVTT 93
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
4161-4247 |
7.26e-07 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 50.19 E-value: 7.26e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4161 PTVHSVKSTSVELSWSEPVNPNGKIIRYEVIRRCFEGKAWgnqtiqadeKIVFTEYNTERNtfmYNDTGLQPWTQCEYKI 4240
Cdd:cd00063 7 LRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDW---------KEVEVTPGSETS---YTLTGLKPGTEYEFRV 74
|
....*..
gi 1796365450 4241 YTWNSAG 4247
Cdd:cd00063 75 RAVNGGG 81
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
1368-1451 |
1.34e-06 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 49.42 E-value: 1.34e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1368 PSVFPLSSYSLNISWEKPADNvtRGKVVGYDINMLSEQSPQqsipmafSQLLHTAKSQELSYTVEGLKPYRIYEFTITLC 1447
Cdd:cd00063 7 LRVTDVTSTSVTLSWTPPEDD--GGPITGYVVEYREKGSGD-------WKEVEVTPGSETSYTLTGLKPGTEYEFRVRAV 77
|
....
gi 1796365450 1448 NSVG 1451
Cdd:cd00063 78 NGGG 81
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
3873-3950 |
1.35e-06 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 49.15 E-value: 1.35e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 3873 PVLKALGSACIEIKWMPPEKPNGI--IINYFIYRRPAGIEEESVLFVWSEGALEFMDegdtLRPFTLYEYRVRACNSKGS 3950
Cdd:smart00060 7 LRVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTG----LKPGTEYEFRVRAVNGAGE 82
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
574-639 |
1.63e-06 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 47.73 E-value: 1.63e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1796365450 574 PCQCNSH---SKSCHYnisvdpfpfehfrgGGGVCDdCEHNTTGRNCELCKDYFFRqvgaDPSAIDVCK 639
Cdd:cd00055 1 PCDCNGHgslSGQCDP--------------GTGQCE-CKPNTTGRRCDRCAPGYYG----LPSQGGGCQ 50
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
3975-4371 |
2.30e-06 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 54.24 E-value: 2.30e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 3975 ATSAHSVLLNWTKPESPNGIISHYRVVYQERPDDPTFNSPTVHAFTVKGTSHQAHLYGLEPFTTYRIGVVAANHAGE-IL 4053
Cdd:COG3401 141 YALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGEsAP 220
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4054 SPW---TLIQTLESSPSGLRnfiVEQKENGRaLLLQWSEPmrTNGVIKTYNIF-----SDGFLEYSGLNR-QFLFRRLDP 4124
Cdd:COG3401 221 SNEvsvTTPTTPPSAPTGLT---ATADTPGS-VTLSWDPV--TESDATGYRVYrsnsgDGPFTKVATVTTtSYTDTGLTN 294
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4125 FTLYTLTLEACTRAGcAHSAP-QPLW--TDEAPPDSQLAPTVHSVKSTSVELSWSEpvNPNGKIIRYEVIRrcfegKAWG 4201
Cdd:COG3401 295 GTTYYYRVTAVDAAG-NESAPsNVVSvtTDLTPPAAPSGLTATAVGSSSITLSWTA--SSDADVTGYNVYR-----STSG 366
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4202 NQTiqadekivFTEYNTERNTFMYNDTGLQPWTQCEYKIYTWNSAGHTCSSWNVVR-TLQAPPEGLSPPVISYVSMNPQK 4280
Cdd:COG3401 367 GGT--------YTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSaTTASAASGESLTASVDAVPLTDV 438
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4281 LLISWIPPEQSNGIIQSYRLQ---RNEMLYPFSFDPVTFNYTDEELLPFSTYSYALQACTSGGCSTSKPTSITTLEAAPS 4357
Cdd:COG3401 439 AGATAAASAASNPGVSAAVLAdggDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAA 518
|
410
....*....|....
gi 1796365450 4358 EVSPPDLWAVSATQ 4371
Cdd:COG3401 519 AVGGAPDGTPNVTG 532
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
1053-1184 |
3.40e-06 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 53.47 E-value: 3.40e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1053 TPFQQPPP-----RGQVQSSSAINLSWSPPDSPNAHwlTYSLLRDGFE------IYTTEDQYPYSiqyflDTDLLPYTKY 1121
Cdd:COG3401 321 TTDLTPPAapsglTATAVGSSSITLSWTASSDADVT--GYNVYRSTSGggtytkIAETVTTTSYT-----DTGLTPGTTY 393
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1796365450 1122 SYYIETTNVHG--STRSVAVTYKTKPGVPEGNLTLSYIIPIGSDSVTLTWTTLSNQSGPIEKYIL 1184
Cdd:COG3401 394 YYKVTAVDAAGneSAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVL 458
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
2930-3015 |
3.54e-06 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 48.18 E-value: 3.54e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2930 NLTASVLNHTAIDVRWAKPTvqDLQGEVEYYTLFWSSATSNDSLK---ILPDVNSHVIGHLKPNTEYwifisVFNgVHSI 3006
Cdd:pfam00041 5 NLTVTDVTSTSLTVSWTPPP--DGNGPITGYEVEYRPKNSGEPWNeitVPGTTTSVTLTGLKPGTEY-----EVR-VQAV 76
|
....*....
gi 1796365450 3007 NSAGLHATT 3015
Cdd:pfam00041 77 NGGGEGPPS 85
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
3026-3087 |
3.60e-06 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 48.26 E-value: 3.60e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1796365450 3026 PEVVIINSTAVRVIWTSPSNPNGVVTEYSIYVNNKLYKTGMNVPG------SFILRDLSPFTIYDIQV 3087
Cdd:cd00063 7 LRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVtpgsetSYTLTGLKPGTEYEFRV 74
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
3777-3856 |
3.90e-06 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 47.79 E-value: 3.90e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 3777 PPYNITV--IGPYSIFVAWIPPGILIPEIpVEYNVL---LNDGSVTPLAFSVGHHQSTLLENLTPFTQYEIRIQACQNGS 3851
Cdd:pfam00041 2 APSNLTVtdVTSTSLTVSWTPPPDGNGPI-TGYEVEyrpKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
....*
gi 1796365450 3852 CGVSS 3856
Cdd:pfam00041 81 EGPPS 85
|
|
| COG4733 |
COG4733 |
Phage-related protein, tail protein J [Mobilome: prophages, transposons]; |
3938-4080 |
4.43e-06 |
|
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
Pssm-ID: 443767 [Multi-domain] Cd Length: 978 Bit Score: 53.41 E-value: 4.43e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 3938 YEYRVRACNSKGsVESLWSLTQT-----LEAPPqdfPAP-WAQATSA-HSVLLNWTKPESPNgiISHYRVVYQERPDdpt 4010
Cdd:COG4733 599 YEVRVRAINALG-VSSAWAASSEttvtgKTAPP---PAPtGLTATGGlGGITLSWSFPVDAD--TLRTEIRYSTTGD--- 669
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4011 FNSPTVHAFTVKGTSHQAHlyGLEPFTTYRIGVVAANHAGEIlSPWTLIQTLESSPSGLRNFIVEQKENG 4080
Cdd:COG4733 670 WASATVAQALYPGNTYTLA--GLKAGQTYYYRARAVDRSGNV-SAWWVSGQASADAAGILDAITGQILET 736
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
4652-4724 |
5.54e-06 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 47.41 E-value: 5.54e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1796365450 4652 TVSLLWTGPLQPNGKVLYYELYRRQiATQPRKSNPVLIyNGSSTSFIDSELLPFTEYEYQVWAVNSAGKAPSS 4724
Cdd:pfam00041 15 SLTVSWTPPPDGNGPITGYEVEYRP-KNSGEPWNEITV-PGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
4155-4247 |
7.61e-06 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 47.22 E-value: 7.61e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4155 PDSQLAPTVHSVKSTSVELSWSEPVNPN--GKIIRYEVIRRcfegkawgnqtiqaDEKIVFTEYNTERNTFMYNDTGLQP 4232
Cdd:smart00060 1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGitGYIVGYRVEYR--------------EEGSEWKEVNVTPSSTSYTLTGLKP 66
|
90
....*....|....*
gi 1796365450 4233 WTQCEYKIYTWNSAG 4247
Cdd:smart00060 67 GTEYEFRVRAVNGAG 81
|
|
| VSP |
pfam03302 |
Giardia variant-specific surface protein; |
617-967 |
7.87e-06 |
|
Giardia variant-specific surface protein;
Pssm-ID: 146106 [Multi-domain] Cd Length: 397 Bit Score: 51.89 E-value: 7.87e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 617 CELCKDYFF------RQVGADPSAIDVCKPC-------------------------DCDTVGTRNGSILCD--QIGGQC- 662
Cdd:pfam03302 1 CDECKPGYElsadktKCTSSAPCKTENCKACsndkrevceecnsnnyltptsqcidDCAKIGNYYYTTNANnkKICKECt 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 663 --NCKRHVSGRQCNQCQNGFYnlqeLDPDGCSPCNCNtsgtvdgditchqnsgqCKCKANVIGLRCDHCNFGfKFLRSFN 740
Cdd:pfam03302 81 vaNCKTCEDQGQCQACNDGFY----KSGDACSPCHES-----------------CKTCSGGTASDCTECLTG-KALRYGN 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 741 DvgcepcqcNLHGSVNKFCNPHSGQCECKkeakglqcdTCrenfyGLDVTNCKAC-DCDTAGSLP-GTVCNAKTGQCI-- 816
Cdd:pfam03302 139 D--------GTKGTCGEGCTTGTGAGACK---------TC-----GLTIDGTSYCsECATETEYPqNGVCTSTAARATat 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 817 CK-PNVEGRQCNKCLEGnfYLRQNNSflclpcnCDKTGTINGSLLCNKSTGQCPCKLGVTGLRCNQcephryNLTIDNFQ 895
Cdd:pfam03302 197 CKaSSVANGMCSSCANG--YFRMNGG-------CYETTKFPGKSVCEEANSGGTCQKEAPGYKLNN------GDLVTCSP 261
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1796365450 896 HCQMCECDSLGTLPGTICDPISGQC-LC-----VPNRQGRRCNQCQPGFYISpgnATGCLPC-SCHTTGAVNHICNSLT 967
Cdd:pfam03302 262 GCKTCTSNTVCTTCMDGYVKTSDSCtKCdssceTCTGATTTCKTCATGYYKS---GTGCVSCtSSESDNGITGVKGCLN 337
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
4450-4516 |
8.00e-06 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 46.84 E-value: 8.00e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1796365450 4450 PTLQVT--GSESIEITWKPPRNPNGQ--IRSYELRRDG------TIVYTGLETRYRDFTLTPGVEYSYTVTASNSQG 4516
Cdd:smart00060 5 SNLRVTdvTSTSVTLSWEPPPDDGITgyIVGYRVEYREegsewkEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
4268-4351 |
1.07e-05 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 47.11 E-value: 1.07e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4268 PPVISYVSMNPQKLLISWIPPEQSNGIIQSYRLQRNEMLYPF-----SFDPVTFNYTDEELLPFSTYSYALQACTSGGCS 4342
Cdd:cd00063 4 PTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDwkeveVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGES 83
|
90
....*....|
gi 1796365450 4343 T-SKPTSITT 4351
Cdd:cd00063 84 PpSESVTVTT 93
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
3680-3767 |
1.45e-05 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 46.72 E-value: 1.45e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 3680 APEGVWVTPrhiiINSTTVELYWSLPEKPNGLVSQYQL------SRNGNLLFLGGSEEQNFTDKNLEPNSRYTYKLEVKT 3753
Cdd:cd00063 3 PPTNLRVTD----VTSTSVTLSWTPPEDDGGPITGYVVeyrekgSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVN 78
|
90
....*....|....*
gi 1796365450 3754 GGGSSA-SDDYIVQT 3767
Cdd:cd00063 79 GGGESPpSESVTVTT 93
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
1956-2051 |
1.85e-05 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 46.34 E-value: 1.85e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1956 SVPTPSRVRSLNGYSIEVTWDEPVV-RGVIEKYILKaYSEDSTRPPRmpsaSAEFVNTSNLTGILTGLLPFKNYAVTLTA 2034
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEDdGGPITGYVVE-YREKGSGDWK----EVEVTPGSETSYTLTGLKPGTEYEFRVRA 76
|
90
....*....|....*..
gi 1796365450 2035 CTLAGCTESSHALNIST 2051
Cdd:cd00063 77 VNGGGESPPSESVTVTT 93
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
2241-2313 |
2.25e-05 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 45.95 E-value: 2.25e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2241 PEGVPAPKAHSYSPDSFNVSWTEPEYPNGVITSYGLYLDG--------ILIHNSSELSYRAYGFAPWSLHSFRVQACTAK 2312
Cdd:cd00063 1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREkgsgdwkeVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80
|
.
gi 1796365450 2313 G 2313
Cdd:cd00063 81 G 81
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1956-2044 |
2.38e-05 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 45.87 E-value: 2.38e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1956 SVPTPSRVRSLNGYSIEVTWDEP-VVRGVIEKYILKAYSEDSTRPPRmpsasaEFVNTSNLTG-ILTGLLPFKNYAVTLT 2033
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPpDGNGPITGYEVEYRPKNSGEPWN------EITVPGTTTSvTLTGLKPGTEYEVRVQ 74
|
90
....*....|.
gi 1796365450 2034 ACTLAGCTESS 2044
Cdd:pfam00041 75 AVNGGGEGPPS 85
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
4444-4516 |
2.45e-05 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 45.48 E-value: 2.45e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4444 PENmdsPTLQVTGSESIEITWKPPRNPNGQIRSYELRR------DGTIVYTGLETRYR-DFT-LTPGVEYSYTVTASNSQ 4515
Cdd:pfam00041 3 PSN---LTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYrpknsgEPWNEITVPGTTTSvTLTgLKPGTEYEVRVQAVNGG 79
|
.
gi 1796365450 4516 G 4516
Cdd:pfam00041 80 G 80
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
4262-4342 |
2.84e-05 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 45.48 E-value: 2.84e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4262 PPEGLSppvISYVsmNPQKLLISWIPPEQSNGIIQSYRLQR---NEMLYPFSF--DPVTFNYTDEELLPFSTYSYALQAC 4336
Cdd:pfam00041 2 APSNLT---VTDV--TSTSLTVSWTPPPDGNGPITGYEVEYrpkNSGEPWNEItvPGTTTSVTLTGLKPGTEYEVRVQAV 76
|
....*.
gi 1796365450 4337 TSGGCS 4342
Cdd:pfam00041 77 NGGGEG 82
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
2930-3003 |
3.57e-05 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 45.30 E-value: 3.57e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1796365450 2930 NLTASVLNHTAIDVRWAKPTVQDLQGEVEYYTLFWSSATSN-DSLKILPDVNSHVIGHLKPNTEYWIFISVFNGV 3003
Cdd:smart00060 6 NLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEwKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
3031-3087 |
3.59e-05 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 45.10 E-value: 3.59e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1796365450 3031 INSTAVRVIWTSPSNPNGVVTEYSIY---VNNKLYKTGMNVPG---SFILRDLSPFTIYDIQV 3087
Cdd:pfam00041 11 VTSTSLTVSWTPPPDGNGPITGYEVEyrpKNSGEPWNEITVPGtttSVTLTGLKPGTEYEVRV 73
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1058-1132 |
3.66e-05 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 45.10 E-value: 3.66e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1058 PPPRG---QVQSSSAINLSWSPPDSPNAHWLTYSLlrdgfeIYTTEDQYPYSIQYFLD--------TDLLPYTKYSYYIE 1126
Cdd:pfam00041 1 SAPSNltvTDVTSTSLTVSWTPPPDGNGPITGYEV------EYRPKNSGEPWNEITVPgtttsvtlTGLKPGTEYEVRVQ 74
|
....*.
gi 1796365450 1127 TTNVHG 1132
Cdd:pfam00041 75 AVNGGG 80
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
4356-4428 |
4.52e-05 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 44.91 E-value: 4.52e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4356 PSEVSPPDLWAVSATQMNVCWSPP--TVQNGKITKYLVRYDNKESL------AGQGLCLLVSHLQPYSQYNFSLVACTNG 4427
Cdd:smart00060 1 PSPPSNLRVTDVTSTSVTLSWEPPpdDGITGYIVGYRVEYREEGSEwkevnvTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80
|
.
gi 1796365450 4428 G 4428
Cdd:smart00060 81 G 81
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
575-629 |
4.72e-05 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 43.45 E-value: 4.72e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 1796365450 575 CQCN---SHSKSCHYNisvdpfpfehfrggGGVCDdCEHNTTGRNCELCKDYFFRQVG 629
Cdd:smart00180 1 CDCDpggSASGTCDPD--------------TGQCE-CKPNVTGRRCDRCAPGYYGDGP 43
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
517-565 |
5.93e-05 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 43.50 E-value: 5.93e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 1796365450 517 RCQCHGHAD---NCDTTSqpYRCLCsqESFTEGLHCDRCLPLYNDKPFRQGD 565
Cdd:cd00055 1 PCDCNGHGSlsgQCDPGT--GQCEC--KPNTTGRRCDRCAPGYYGLPSQGGG 48
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
2210-2465 |
6.13e-05 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 49.62 E-value: 6.13e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2210 PGNKYLIKLGACTGGGC-TVSEASEALTDEDIPEGVPAPKAHSYSPDSFNVSWTEPEYPNgvITSYGLYLDGI------L 2282
Cdd:COG3401 201 PGTTYYYRVAATDTGGEsAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESD--ATGYRVYRSNSgdgpftK 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2283 IHNSSELSYRAYGFAPWSLHSFRVQACTAKGC--ALGPLVENRTLEAPPEGTVNVFVKTQGSRKAHVRWEAPfrpngllt 2360
Cdd:COG3401 279 VATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNesAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTAS-------- 350
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2361 HSVLFTG--IFYVDPVGNNYTLLNVTkvmysgeETNLWVLIDGLVPFTNYTVQVNISNSQG--SLITDPITiAMPPGAPD 2436
Cdd:COG3401 351 SDADVTGynVYRSTSGGGTYTKIAET-------VTTTSYTDTGLTPGTTYYYKVTAVDAAGneSAPSEEVS-ATTASAAS 422
|
250 260
....*....|....*....|....*....
gi 1796365450 2437 GVLPPRLSSATPTSLQVVWSTPARNNAPG 2465
Cdd:COG3401 423 GESLTASVDAVPLTDVAGATAAASAASNP 451
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
3883-3949 |
6.52e-05 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 44.33 E-value: 6.52e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1796365450 3883 IEIKWMPPEKPNGIIINYFIYRRPAGIEEESVLF--VWSEGALEFMDegdtLRPFTLYEYRVRACNSKG 3949
Cdd:pfam00041 16 LTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEItvPGTTTSVTLTG----LKPGTEYEVRVQAVNGGG 80
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
3777-3856 |
7.78e-05 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 44.41 E-value: 7.78e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 3777 PPYNITV--IGPYSIFVAWIPPGILIPEIpVEYNVLL---NDGSVTPLAFSVGHHQSTLLENLTPFTQYEIRIQACQNGS 3851
Cdd:cd00063 3 PPTNLRVtdVTSTSVTLSWTPPEDDGGPI-TGYVVEYrekGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
....*
gi 1796365450 3852 CGVSS 3856
Cdd:cd00063 82 ESPPS 86
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
575-632 |
1.13e-04 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 42.73 E-value: 1.13e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1796365450 575 CQCN---SHSKSCHynisvdpfpfehfrGGGGVCDdCEHNTTGRNCELCKDYFFRQVGADP 632
Cdd:pfam00053 1 CDCNphgSLSDTCD--------------PETGQCL-CKPGVTGRHCDRCKPGYYGLPSDPP 46
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
2824-2912 |
1.24e-04 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 43.56 E-value: 1.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2824 VGPLSVIPLSESYVVISWQPPSKPNGPNLRYELLRRkiqqplasnPPEDLNRWHNIY-SGTQWLYEDKGLSRFTTYEYML 2902
Cdd:pfam00041 3 PSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYR---------PKNSGEPWNEITvPGTTTSVTLTGLKPGTEYEVRV 73
|
90
....*....|
gi 1796365450 2903 FVHNSVGFTP 2912
Cdd:pfam00041 74 QAVNGGGEGP 83
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
2821-2909 |
2.29e-04 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 42.99 E-value: 2.29e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2821 PQNVGPLSVIPLSESYVVISWQPPSKPN--GPNLRYELLRRkiqqplasnppEDLNRWHNIYSGTQWL-YEDKGLSRFTT 2897
Cdd:smart00060 1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGitGYIVGYRVEYR-----------EEGSEWKEVNVTPSSTsYTLTGLKPGTE 69
|
90
....*....|..
gi 1796365450 2898 YEYMLFVHNSVG 2909
Cdd:smart00060 70 YEFRVRAVNGAG 81
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
518-560 |
3.74e-04 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 41.18 E-value: 3.74e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 1796365450 518 CQCHGHA---DNCDttSQPYRCLCSQesFTEGLHCDRCLPLYNDKP 560
Cdd:pfam00053 1 CDCNPHGslsDTCD--PETGQCLCKP--GVTGRHCDRCKPGYYGLP 42
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
4267-4342 |
3.82e-04 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 42.22 E-value: 3.82e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4267 SPPVISYVSMNPQKLLISWIPPEQSNGI--IQSYRLQRNEMLYPF---SFDPVTFNYTDEELLPFSTYSYALQACTSGGC 4341
Cdd:smart00060 3 PPSNLRVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYREEGSEWkevNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGE 82
|
.
gi 1796365450 4342 S 4342
Cdd:smart00060 83 G 83
|
|
| COG4733 |
COG4733 |
Phage-related protein, tail protein J [Mobilome: prophages, transposons]; |
4451-4627 |
5.06e-04 |
|
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
Pssm-ID: 443767 [Multi-domain] Cd Length: 978 Bit Score: 46.86 E-value: 5.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4451 TLQVTGSESIEITWKPPRNPNgqirSYEL--RRDG---TIVYTGLETRYRDFTLTPGvEYSYTVTASNSQGgILSP---- 4521
Cdd:COG4733 545 VAQGTAVTTLTVSWDAPAGAV----AYEVewRRDDgnwVSVPRTSGTSFEVPGIYAG-DYEVRVRAINALG-VSSAwaas 618
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 4522 ----LVKDRTSPSAPSGMEPpklqARGPQEILVNWDPPVrtNGDIINYtlfirELFERETKIIHINTTHNSFG-MQSYIV 4596
Cdd:COG4733 619 settVTGKTAPPPAPTGLTA----TGGLGGITLSWSFPV--DADTLRT-----EIRYSTTGDWASATVAQALYpGNTYTL 687
|
170 180 190
....*....|....*....|....*....|.
gi 1796365450 4597 NQLKPFHRYEIRIQACTTLGCASSDWTFIQT 4627
Cdd:COG4733 688 AGLKAGQTYYYRARAVDRSGNVSAWWVSGQA 718
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
3503-3586 |
6.22e-04 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 42.10 E-value: 6.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 3503 SPPTWTKIDNL-EDTIVLNWRKPIQSNGPIIYYILLRNG--------IERFRGTSLSFSDKeGIQPFQEYSYQLKACTVA 3573
Cdd:cd00063 2 SPPTNLRVTDVtSTSVTLSWTPPEDDGGPITGYVVEYREkgsgdwkeVEVTPGSETSYTLT-GLKPGTEYEFRVRAVNGG 80
|
90
....*....|...
gi 1796365450 3574 GCATSSKVVAATT 3586
Cdd:cd00063 81 GESPPSESVTVTT 93
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
3449-3494 |
7.06e-04 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 41.71 E-value: 7.06e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 1796365450 3449 ETIHTGSVNTYSYTDVNLKPYMTYEYRISAWNSYGRG-LSKAVRART 3494
Cdd:cd00063 47 KEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESpPSESVTVTT 93
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
2241-2313 |
7.14e-04 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 41.45 E-value: 7.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2241 PEGVPAPKAHSYSPDSFNVSWTEPEYPNGV--ITSYGLYLDG------ILIHNSSELSYRAYGFAPWSLHSFRVQACTAK 2312
Cdd:smart00060 1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYREegsewkEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80
|
.
gi 1796365450 2313 G 2313
Cdd:smart00060 81 G 81
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
1060-1143 |
1.23e-03 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 40.94 E-value: 1.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1060 PRGQVQSSSAINLSWSPPDSPNAHWLTYSLLR--DGFEIYTTEDQYPYSIQYFLDTDLLPYTKYSYYIETTNVHG-STRS 1136
Cdd:cd00063 7 LRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYreKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGeSPPS 86
|
....*..
gi 1796365450 1137 VAVTYKT 1143
Cdd:cd00063 87 ESVTVTT 93
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
3680-3758 |
1.31e-03 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 40.68 E-value: 1.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 3680 APEGVWVTPrhiiINSTTVELYWSLPEKPN------GLVSQYQLSRNGNLLFLGGSEEQNFTDKNLEPNSRYTYKLEVKT 3753
Cdd:smart00060 3 PPSNLRVTD----VTSTSVTLSWEPPPDDGitgyivGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVN 78
|
....*
gi 1796365450 3754 GGGSS 3758
Cdd:smart00060 79 GAGEG 83
|
|
| Pur_ac_phosph_N |
pfam16656 |
Purple acid Phosphatase, N-terminal domain; This domain is found at the N-terminus of Purple ... |
1256-1357 |
1.49e-03 |
|
Purple acid Phosphatase, N-terminal domain; This domain is found at the N-terminus of Purple acid phosphatase proteins.
Pssm-ID: 465220 [Multi-domain] Cd Length: 93 Bit Score: 40.86 E-value: 1.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1256 STELHVEWSPPAELNGIIIRYELYMRRLRSTKETTSEE-SRVFQSSGWLspHSFvesanenalkppqtmtTITGLEPYTK 1334
Cdd:pfam16656 12 STSMTVSWVTPSAVTSPVVQYGTSSSALTSTATATSSTyTTGDGGTGYI--HRA----------------TLTGLEPGTT 73
|
90 100
....*....|....*....|...
gi 1796365450 1335 YEFRVLAvnmAGSVSSAWVSERT 1357
Cdd:pfam16656 74 YYYRVGD---DNGGWSEVYSFTT 93
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
1956-2039 |
1.52e-03 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 40.68 E-value: 1.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1956 SVPTPSRVRSLNGYSIEVTWDEPVvRGVIEKYILKAYSEDSTRPPRMPSASaefVNTSNLTGILTGLLPFKNYAVTLTAC 2035
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPP-DDGITGYIVGYRVEYREEGSEWKEVN---VTPSSTSYTLTGLKPGTEYEFRVRAV 77
|
....
gi 1796365450 2036 TLAG 2039
Cdd:smart00060 78 NGAG 81
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
518-561 |
1.63e-03 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 39.22 E-value: 1.63e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 1796365450 518 CQCH--GHADN-CDTTSqpYRCLCsqESFTEGLHCDRCLPLYNDKPF 561
Cdd:smart00180 1 CDCDpgGSASGtCDPDT--GQCEC--KPNVTGRRCDRCAPGYYGDGP 43
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
2329-2428 |
1.72e-03 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 40.56 E-value: 1.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2329 PEGTVNVFVKTQGSRKAHVRWEAPFRPNGLLTHsvlFTgIFYVDPVGNNYTLLNVTKVmysgeeTNLWVLIDGLVPFTNY 2408
Cdd:cd00063 1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITG---YV-VEYREKGSGDWKEVEVTPG------SETSYTLTGLKPGTEY 70
|
90 100
....*....|....*....|.
gi 1796365450 2409 TVQVNISNSQG-SLITDPITI 2428
Cdd:cd00063 71 EFRVRAVNGGGeSPPSESVTV 91
|
|
| Pur_ac_phosph_N |
pfam16656 |
Purple acid Phosphatase, N-terminal domain; This domain is found at the N-terminus of Purple ... |
3973-4061 |
1.86e-03 |
|
Purple acid Phosphatase, N-terminal domain; This domain is found at the N-terminus of Purple acid phosphatase proteins.
Pssm-ID: 465220 [Multi-domain] Cd Length: 93 Bit Score: 40.47 E-value: 1.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 3973 AQATSAHSVLLNWTKPESPNGIISHYRVVYQERPDDPTFNSPTVHAFT-VKGTSHQAHLYGLEPFTTYRIGVVAANHage 4051
Cdd:pfam16656 7 SLTGDSTSMTVSWVTPSAVTSPVVQYGTSSSALTSTATATSSTYTTGDgGTGYIHRATLTGLEPGTTYYYRVGDDNG--- 83
|
90
....*....|
gi 1796365450 4052 ILSPWTLIQT 4061
Cdd:pfam16656 84 GWSEVYSFTT 93
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
1058-1133 |
2.16e-03 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 40.29 E-value: 2.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1058 PPPRGQVQ----SSSAINLSWSPPDSPNAHW--LTYSLLRDGFEIYTTEDQYPYSIQYFLDTDLLPYTKYSYYIETTNVH 1131
Cdd:smart00060 1 PSPPSNLRvtdvTSTSVTLSWEPPPDDGITGyiVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80
|
..
gi 1796365450 1132 GS 1133
Cdd:smart00060 81 GE 82
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
2244-2313 |
2.25e-03 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 40.09 E-value: 2.25e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1796365450 2244 VPAPKAHSYSPDSFNVSWTEPEYPNGVITSY---------GLYLDGILIHNsSELSYRAYGFAPWSLHSFRVQACTAKG 2313
Cdd:pfam00041 3 PSNLTVTDVTSTSLTVSWTPPPDGNGPITGYeveyrpknsGEPWNEITVPG-TTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
3445-3485 |
2.55e-03 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 39.91 E-value: 2.55e-03
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 1796365450 3445 SSAEETIHTGSVNTYSYTDVNLKPYMTYEYRISAWNSYGRG 3485
Cdd:smart00060 43 EGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGEG 83
|
|
| TNFRSF4 |
cd13406 |
Tumor necrosis factor receptor superfamily member 4 (TNFRSF4), also known as CD134 or OXO40; ... |
930-1008 |
3.64e-03 |
|
Tumor necrosis factor receptor superfamily member 4 (TNFRSF4), also known as CD134 or OXO40; TNFRSF4 (also known as OX40, ACT35, CD134, IMD16, TXGP1L) activates NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. It also promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. It is primarily expressed on activated CD4+ and CD8+ T cells, where it is transiently expressed and upregulated on the most recently antigen-activated T cells within inflammatory lesions. This makes it an attractive target to modulate immune responses, i.e. TNFRSF4 (OX40) blocking agents to inhibit adverse inflammation or agonists to enhance immune responses. An artificially created biologic fusion protein, OX40-immunoglobulin (OX40-Ig), prevents OX40 from reaching the T-cell receptors, thus reducing the T-cell response. Some single nucleotide polymorphisms (SNPs) of its natural ligand OX40 ligand (OX40L, CD252), which is also found on activated T cells, have been associated with systemic lupus erythematosus.
Pssm-ID: 276911 [Multi-domain] Cd Length: 142 Bit Score: 40.84 E-value: 3.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 930 RCNQCQPGFYISPGNATGCLPCSchttgavnhICNSLTGQC-----------VC--------QDASIAGQRCDQCKDHYF 990
Cdd:cd13406 35 VCSPCEPGFYNEAVNYEPCKPCT---------QCNQRSGSEekqkctktsdtVCrcrpgtqpLDSYKPGVDCVPCPPGHF 105
|
90
....*....|....*....
gi 1796365450 991 GfDPQTGRCQP-CNCHLSG 1008
Cdd:cd13406 106 S-RGDNQACKPwTNCSLAG 123
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
2334-2419 |
4.64e-03 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 39.32 E-value: 4.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2334 NVFVKTQGSRKAHVRWEAPFRPNGLLTHsvlFTgIFYVDPVGNNYTL-LNVTKVMYSgeetnlwVLIDGLVPFTNYTVQV 2412
Cdd:pfam00041 5 NLTVTDVTSTSLTVSWTPPPDGNGPITG---YE-VEYRPKNSGEPWNeITVPGTTTS-------VTLTGLKPGTEYEVRV 73
|
....*..
gi 1796365450 2413 NISNSQG 2419
Cdd:pfam00041 74 QAVNGGG 80
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
3777-3846 |
7.06e-03 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 38.75 E-value: 7.06e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1796365450 3777 PPYNITV--IGPYSIFVAWIPPGILIPEIP-VEYNVLLNDGSVTPLAFSVGHHQ-STLLENLTPFTQYEIRIQA 3846
Cdd:smart00060 3 PPSNLRVtdVTSTSVTLSWEPPPDDGITGYiVGYRVEYREEGSEWKEVNVTPSStSYTLTGLKPGTEYEFRVRA 76
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
1865-2127 |
7.97e-03 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 42.68 E-value: 7.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1865 DVKFTRGAVVNLASVSSGAVRVNLDGCLSTDSAVNCRGNDSILVYQGKEQSVYEGGLQPFTEYLYRVIASHEGG-SVYSD 1943
Cdd:COG3401 143 LGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGeSAPSN 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 1944 WSRGRTTGAAPqSVPTPSRVRSLNGYSIEVTWDEPVVRGVIEKYILKAYSEDSTrpprmpsaSAEFVNTSNLTGILTGLL 2023
Cdd:COG3401 223 EVSVTTPTTPP-SAPTGLTATADTPGSVTLSWDPVTESDATGYRVYRSNSGDGP--------FTKVATVTTTSYTDTGLT 293
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796365450 2024 PFKNYAVTLTACTLAGcTES--SHALNISTPQEAPQEVQPPVAKSLPSSLLL-SWNPPkkANGIITQYCLY----MDGRL 2096
Cdd:COG3401 294 NGTTYYYRVTAVDAAG-NESapSNVVSVTTDLTPPAAPSGLTATAVGSSSITlSWTAS--SDADVTGYNVYrstsGGGTY 370
|
250 260 270
....*....|....*....|....*....|....
gi 1796365450 2097 IY---SGSEENYIVTDLAVFTPHQFLLSACTHVG 2127
Cdd:COG3401 371 TKiaeTVTTTSYTDTGLTPGTTYYYKVTAVDAAG 404
|
|
| |
