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Conserved domains on  [gi|161016770|ref|NP_997086|]
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proline-rich protein 36 [Mus musculus]

Protein Classification

APache family protein( domain architecture ID 10634040)

APache family protein is a DUF4596 domain-containing protein similar to Homo sapiens AP2-interacting clathrin-endocytosis protein (APache, also known as KIAA1107) that is involved in clathrin-mediated endocytosis at the synapse

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 434-842 1.20e-12

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 72.66  E-value: 1.20e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770  434 PPPRAVISSSPPPLIQNMPPNQASSA------TLPQETLSAMPF-----SPAPLSLASSPPQLLPSPPISPQNLPTSLVT 502
Cdd:PHA03247 2559 APPAAPDRSVPPPRPAPRPSEPAVTSrarrpdAPPQSARPRAPVddrgdPRGPAPPSPLPPDTHAPDPPPPSPSPAANEP 2638

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770  503 SSQLPLSTPFRANFSESPPLPRATLANRTTPSLQDPLflAISPPVSSSTSISPPL--PTSSVVTPPLRLPLSQTLPTSQA 580
Cdd:PHA03247 2639 DPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQ--ASSPPQRPRRRAARPTvgSLTSLADPPPPPPTPEPAPHALV 2716

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770  581 SLLTLPPSLASSPQPATPPPLALSPLSTQLSTGSPSLQASPSFLPTPPMQPRALPSPSLQAPPVTYPLPLSSPPASPPLP 660
Cdd:PHA03247 2717 SATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRE 2796

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770  661 ALLSPPASPPLESPLSPSASPSSPLATP-PPEAPPSLGSPTLSPLATPPPQTPPLAF-----------PPLPASTSSLDT 728
Cdd:PHA03247 2797 SLPSPWDPADPPAAVLAPAAALPPAASPaGPLPPPTSAQPTAPPPPPGPPPPSLPLGgsvapggdvrrRPPSRSPAAKPA 2876

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770  729 ATCFPQGPLLALPPLQTSPSPLTIPCPQTPPSLALPSLQSPSSPLATATPPLQIPLVVLPTLQTPPSPLTTFPPGVPPGL 808
Cdd:PHA03247 2877 APARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPS 2956

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 161016770  809 TSPVVQPPSPPASPPLQAPR-RPPTPGPDVPITGP 842
Cdd:PHA03247 2957 GAVPQPWLGALVPGRVAVPRfRVPQPAPSREAPAS 2991
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 12-620 4.09e-11

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 67.66  E-value: 4.09e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770   12 APRMPSSRPPGLLTPRPPsgsARPPPPVTTAALRVLEangAMGRRSLVERAPGVCKAALPQTSKAALPQTSKAALPQTSK 91
Cdd:PHA03247 2508 APPAPSRLAPAILPDEPV---GEPVHPRMLTWIRGLE---ELASDDAGDPPPPLPPAAPPAAPDRSVPPPRPAPRPSEPA 2581

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770   92 AALPQTSKAALPQTTIHGAPARSAGAGPRSPANRPPASGKGERAPMKTPGQGSISSPGRASSGIARPGPVVQKRLQPPTK 171
Cdd:PHA03247 2582 VTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRV 2661

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770  172 EPSARGKTPETPKR-NTLNSGTRRVLSADSLGPTSGAPSPAITRRSRAPAtevglPQPAPSARQRPLTTEAARKPGSSAS 250
Cdd:PHA03247 2662 SRPRRARRLGRAAQaSSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPA-----PHALVSATPLPPGPAAARQASPALP 2736

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770  251 EPSATELSPAFRRRSVAGGSLQKPVSRSLIPSATPQLSPSrSGVSPRVTPRAPAHTSQLKSKGQQALHPTQTTVPRKNKP 330
Cdd:PHA03247 2737 AAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPA-AGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPA 2815

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770  331 SVQSLIPASSLVTPTPPGASSVQGPDDPSQTTLPPSPPTTPPLPASLQLLQPQASSQAVPHSQSG--QGSPSPPPLSLQN 408
Cdd:PHA03247 2816 AALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARppVRRLARPAVSRST 2895

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770  409 LPSTPATPPLLAPPTSLDTEEASDSPPPRAVISSSPPPLIQNMPPNQASSATLPQETLSAMPFSPAPLSLASSPPQLLPS 488
Cdd:PHA03247 2896 ESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVP 2975

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770  489 PPISPQNLPtslvtssqlPLSTPfranfsESPPLPRATLANRTTPSLQDPLFLAIS---PPVSSSTSISPPLPTSSVVTP 565
Cdd:PHA03247 2976 RFRVPQPAP---------SREAP------ASSTPPLTGHSLSRVSSWASSLALHEEtdpPPVSLKQTLWPPDDTEDSDAD 3040

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 161016770  566 PLRLPLSQTLPTSQASLLTLPPSLASSPQPATPPPLALSPLSTQLSTGSPSLQAS 620
Cdd:PHA03247 3041 SLFDSDSERSDLEALDPLPPEPHDPFAHEPDPATPEAGARESPSSQFGPPPLSAN 3095
DUF4596 pfam15363
Domain of unknown function (DUF4596); This domain family is found in eukaryotes, and is ...
 1056-1098 7.96e-10

Domain of unknown function (DUF4596); This domain family is found in eukaryotes, and is approximately 50 amino acids in length. There is a conserved ELET sequence motif. There are two completely conserved residues (S and E) that may be functionally important.


:

Pssm-ID: 464673  Cd Length: 46  Bit Score: 55.31  E-value: 7.96e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 161016770  1056 RWAELLSPLDESRASITsVTSFSPDDVASPQGDWTVVEVETFH 1098
Cdd:pfam15363    5 RWSELSSPLDDSSASIT-VTSFSPEDGCSPQGEWTILELETQH 46
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
 434-842 1.20e-12

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 72.66  E-value: 1.20e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770  434 PPPRAVISSSPPPLIQNMPPNQASSA------TLPQETLSAMPF-----SPAPLSLASSPPQLLPSPPISPQNLPTSLVT 502
Cdd:PHA03247 2559 APPAAPDRSVPPPRPAPRPSEPAVTSrarrpdAPPQSARPRAPVddrgdPRGPAPPSPLPPDTHAPDPPPPSPSPAANEP 2638

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770  503 SSQLPLSTPFRANFSESPPLPRATLANRTTPSLQDPLflAISPPVSSSTSISPPL--PTSSVVTPPLRLPLSQTLPTSQA 580
Cdd:PHA03247 2639 DPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQ--ASSPPQRPRRRAARPTvgSLTSLADPPPPPPTPEPAPHALV 2716

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770  581 SLLTLPPSLASSPQPATPPPLALSPLSTQLSTGSPSLQASPSFLPTPPMQPRALPSPSLQAPPVTYPLPLSSPPASPPLP 660
Cdd:PHA03247 2717 SATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRE 2796

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770  661 ALLSPPASPPLESPLSPSASPSSPLATP-PPEAPPSLGSPTLSPLATPPPQTPPLAF-----------PPLPASTSSLDT 728
Cdd:PHA03247 2797 SLPSPWDPADPPAAVLAPAAALPPAASPaGPLPPPTSAQPTAPPPPPGPPPPSLPLGgsvapggdvrrRPPSRSPAAKPA 2876

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770  729 ATCFPQGPLLALPPLQTSPSPLTIPCPQTPPSLALPSLQSPSSPLATATPPLQIPLVVLPTLQTPPSPLTTFPPGVPPGL 808
Cdd:PHA03247 2877 APARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPS 2956

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 161016770  809 TSPVVQPPSPPASPPLQAPR-RPPTPGPDVPITGP 842
Cdd:PHA03247 2957 GAVPQPWLGALVPGRVAVPRfRVPQPAPSREAPAS 2991
PHA03247 PHA03247
large tegument protein UL36; Provisional
 12-620 4.09e-11

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 67.66  E-value: 4.09e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770   12 APRMPSSRPPGLLTPRPPsgsARPPPPVTTAALRVLEangAMGRRSLVERAPGVCKAALPQTSKAALPQTSKAALPQTSK 91
Cdd:PHA03247 2508 APPAPSRLAPAILPDEPV---GEPVHPRMLTWIRGLE---ELASDDAGDPPPPLPPAAPPAAPDRSVPPPRPAPRPSEPA 2581

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770   92 AALPQTSKAALPQTTIHGAPARSAGAGPRSPANRPPASGKGERAPMKTPGQGSISSPGRASSGIARPGPVVQKRLQPPTK 171
Cdd:PHA03247 2582 VTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRV 2661

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770  172 EPSARGKTPETPKR-NTLNSGTRRVLSADSLGPTSGAPSPAITRRSRAPAtevglPQPAPSARQRPLTTEAARKPGSSAS 250
Cdd:PHA03247 2662 SRPRRARRLGRAAQaSSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPA-----PHALVSATPLPPGPAAARQASPALP 2736

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770  251 EPSATELSPAFRRRSVAGGSLQKPVSRSLIPSATPQLSPSrSGVSPRVTPRAPAHTSQLKSKGQQALHPTQTTVPRKNKP 330
Cdd:PHA03247 2737 AAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPA-AGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPA 2815

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770  331 SVQSLIPASSLVTPTPPGASSVQGPDDPSQTTLPPSPPTTPPLPASLQLLQPQASSQAVPHSQSG--QGSPSPPPLSLQN 408
Cdd:PHA03247 2816 AALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARppVRRLARPAVSRST 2895

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770  409 LPSTPATPPLLAPPTSLDTEEASDSPPPRAVISSSPPPLIQNMPPNQASSATLPQETLSAMPFSPAPLSLASSPPQLLPS 488
Cdd:PHA03247 2896 ESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVP 2975

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770  489 PPISPQNLPtslvtssqlPLSTPfranfsESPPLPRATLANRTTPSLQDPLFLAIS---PPVSSSTSISPPLPTSSVVTP 565
Cdd:PHA03247 2976 RFRVPQPAP---------SREAP------ASSTPPLTGHSLSRVSSWASSLALHEEtdpPPVSLKQTLWPPDDTEDSDAD 3040

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 161016770  566 PLRLPLSQTLPTSQASLLTLPPSLASSPQPATPPPLALSPLSTQLSTGSPSLQAS 620
Cdd:PHA03247 3041 SLFDSDSERSDLEALDPLPPEPHDPFAHEPDPATPEAGARESPSSQFGPPPLSAN 3095
DUF4596 pfam15363
Domain of unknown function (DUF4596); This domain family is found in eukaryotes, and is ...
 1056-1098 7.96e-10

Domain of unknown function (DUF4596); This domain family is found in eukaryotes, and is approximately 50 amino acids in length. There is a conserved ELET sequence motif. There are two completely conserved residues (S and E) that may be functionally important.


Pssm-ID: 464673  Cd Length: 46  Bit Score: 55.31  E-value: 7.96e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 161016770  1056 RWAELLSPLDESRASITsVTSFSPDDVASPQGDWTVVEVETFH 1098
Cdd:pfam15363    5 RWSELSSPLDDSSASIT-VTSFSPEDGCSPQGEWTILELETQH 46
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 381-779 6.77e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.52  E-value: 6.77e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770   381 QPQASSQAVPHSQSGQGSPSPPPLSLQNLPSTPATPPLLAPPTSLDTEEASDSPPPRAVISSSPP-PLIQNMPPNQASSA 459
Cdd:pfam03154  163 QQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPhTLIQQTPTLHPQRL 242

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770   460 TLPQETLSAMPFSPAPlslassppqllpsPPISPQNLPTSLVTSSQLPLSTPFRANFSESPPLPRATLANRTTPSLQDPL 539
Cdd:pfam03154  243 PSPHPPLQPMTQPPPP-------------SQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQV 309

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770   540 FLAISPPVSSSTSISPPLPTSSVVTPPLRLPLSQTLPTSQASLL------TLPPSLASSPQPATPPPLALSPLSTQLSTG 613
Cdd:pfam03154  310 PPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPhikpppTTPIPQLPNPQSHKHPPHLSGPSPFQMNSN 389

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770   614 SPSLQASPSFLPTPPMQPRALPSPSLQAPPvtYPLPLSSPPASPPLPALLSPPASPPLESPLSPSASPSSPLATPPPEAP 693
Cdd:pfam03154  390 LPPPPALKPLSSLSTHHPPSAHPPPLQLMP--QSQQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPF 467

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770   694 PSLGSPTLSPLATPPPQTPPLAFPPLPASTSSLDTATCFPQGPLLALPPLQTSPSPLTIP-CPQTPPslalPSLQSPSSP 772
Cdd:pfam03154  468 VPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVSCPLPPVQIKEEALDEAeEPESPP----PPPRSPSPE 543


                   ....*..
gi 161016770   773 LATATPP 779
Cdd:pfam03154  544 PTVVNTP 550
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
 434-842 1.20e-12

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 72.66  E-value: 1.20e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770  434 PPPRAVISSSPPPLIQNMPPNQASSA------TLPQETLSAMPF-----SPAPLSLASSPPQLLPSPPISPQNLPTSLVT 502
Cdd:PHA03247 2559 APPAAPDRSVPPPRPAPRPSEPAVTSrarrpdAPPQSARPRAPVddrgdPRGPAPPSPLPPDTHAPDPPPPSPSPAANEP 2638

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770  503 SSQLPLSTPFRANFSESPPLPRATLANRTTPSLQDPLflAISPPVSSSTSISPPL--PTSSVVTPPLRLPLSQTLPTSQA 580
Cdd:PHA03247 2639 DPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQ--ASSPPQRPRRRAARPTvgSLTSLADPPPPPPTPEPAPHALV 2716

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770  581 SLLTLPPSLASSPQPATPPPLALSPLSTQLSTGSPSLQASPSFLPTPPMQPRALPSPSLQAPPVTYPLPLSSPPASPPLP 660
Cdd:PHA03247 2717 SATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRE 2796

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770  661 ALLSPPASPPLESPLSPSASPSSPLATP-PPEAPPSLGSPTLSPLATPPPQTPPLAF-----------PPLPASTSSLDT 728
Cdd:PHA03247 2797 SLPSPWDPADPPAAVLAPAAALPPAASPaGPLPPPTSAQPTAPPPPPGPPPPSLPLGgsvapggdvrrRPPSRSPAAKPA 2876

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770  729 ATCFPQGPLLALPPLQTSPSPLTIPCPQTPPSLALPSLQSPSSPLATATPPLQIPLVVLPTLQTPPSPLTTFPPGVPPGL 808
Cdd:PHA03247 2877 APARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPS 2956

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 161016770  809 TSPVVQPPSPPASPPLQAPR-RPPTPGPDVPITGP 842
Cdd:PHA03247 2957 GAVPQPWLGALVPGRVAVPRfRVPQPAPSREAPAS 2991
PHA03247 PHA03247
large tegument protein UL36; Provisional
 12-620 4.09e-11

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 67.66  E-value: 4.09e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770   12 APRMPSSRPPGLLTPRPPsgsARPPPPVTTAALRVLEangAMGRRSLVERAPGVCKAALPQTSKAALPQTSKAALPQTSK 91
Cdd:PHA03247 2508 APPAPSRLAPAILPDEPV---GEPVHPRMLTWIRGLE---ELASDDAGDPPPPLPPAAPPAAPDRSVPPPRPAPRPSEPA 2581

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770   92 AALPQTSKAALPQTTIHGAPARSAGAGPRSPANRPPASGKGERAPMKTPGQGSISSPGRASSGIARPGPVVQKRLQPPTK 171
Cdd:PHA03247 2582 VTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRV 2661

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770  172 EPSARGKTPETPKR-NTLNSGTRRVLSADSLGPTSGAPSPAITRRSRAPAtevglPQPAPSARQRPLTTEAARKPGSSAS 250
Cdd:PHA03247 2662 SRPRRARRLGRAAQaSSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPA-----PHALVSATPLPPGPAAARQASPALP 2736

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770  251 EPSATELSPAFRRRSVAGGSLQKPVSRSLIPSATPQLSPSrSGVSPRVTPRAPAHTSQLKSKGQQALHPTQTTVPRKNKP 330
Cdd:PHA03247 2737 AAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPA-AGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPA 2815

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770  331 SVQSLIPASSLVTPTPPGASSVQGPDDPSQTTLPPSPPTTPPLPASLQLLQPQASSQAVPHSQSG--QGSPSPPPLSLQN 408
Cdd:PHA03247 2816 AALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARppVRRLARPAVSRST 2895

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770  409 LPSTPATPPLLAPPTSLDTEEASDSPPPRAVISSSPPPLIQNMPPNQASSATLPQETLSAMPFSPAPLSLASSPPQLLPS 488
Cdd:PHA03247 2896 ESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVP 2975

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770  489 PPISPQNLPtslvtssqlPLSTPfranfsESPPLPRATLANRTTPSLQDPLFLAIS---PPVSSSTSISPPLPTSSVVTP 565
Cdd:PHA03247 2976 RFRVPQPAP---------SREAP------ASSTPPLTGHSLSRVSSWASSLALHEEtdpPPVSLKQTLWPPDDTEDSDAD 3040

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 161016770  566 PLRLPLSQTLPTSQASLLTLPPSLASSPQPATPPPLALSPLSTQLSTGSPSLQAS 620
Cdd:PHA03247 3041 SLFDSDSERSDLEALDPLPPEPHDPFAHEPDPATPEAGARESPSSQFGPPPLSAN 3095
DUF4596 pfam15363
Domain of unknown function (DUF4596); This domain family is found in eukaryotes, and is ...
 1056-1098 7.96e-10

Domain of unknown function (DUF4596); This domain family is found in eukaryotes, and is approximately 50 amino acids in length. There is a conserved ELET sequence motif. There are two completely conserved residues (S and E) that may be functionally important.


Pssm-ID: 464673  Cd Length: 46  Bit Score: 55.31  E-value: 7.96e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 161016770  1056 RWAELLSPLDESRASITsVTSFSPDDVASPQGDWTVVEVETFH 1098
Cdd:pfam15363    5 RWSELSSPLDDSSASIT-VTSFSPEDGCSPQGEWTILELETQH 46
PHA03247 PHA03247
large tegument protein UL36; Provisional
 119-715 1.57e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 56.10  E-value: 1.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770  119 PRSPANRPPASGKGERAPMKTPGQGSISSPGRAssgiARPGPVVQKrlqpPTKEPSARGKTPETPKRNTLNSGTRRVLSA 198
Cdd:PHA03247 2475 PGAPVYRRPAEARFPFAAGAAPDPGGGGPPDPD----APPAPSRLA----PAILPDEPVGEPVHPRMLTWIRGLEELASD 2546

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770  199 DSLGPTSGAPSPAitrRSRAPATEVGLPQPAPSARQRPLTTEAAR----------------------KPGSSASEPSATE 256
Cdd:PHA03247 2547 DAGDPPPPLPPAA---PPAAPDRSVPPPRPAPRPSEPAVTSRARRpdappqsarprapvddrgdprgPAPPSPLPPDTHA 2623

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770  257 LSPAFRRRSVAGGSLQKPVSRSLIPSATPQLSPSRSGVSPRVTPRAPAHTSQLKSKGQ----QALHPTQTTVPRKNKPSV 332
Cdd:PHA03247 2624 PDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQrprrRAARPTVGSLTSLADPPP 2703

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770  333 QSLIPASSlVTPTPPGASSVQGPDDPSQTTLPPSPPTTPPLPASLQLLQPQASSQAVPHSQSGQGSPSPPPLSLQNLPST 412
Cdd:PHA03247 2704 PPPTPEPA-PHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRR 2782

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770  413 PATPPLLAPPTSLDTEEASDSPPPRAVISSSPPPliqNMPPNQASSATLPQETlSAMPFSPAPLSlASSPPQLLPSPPIS 492
Cdd:PHA03247 2783 LTRPAVASLSESRESLPSPWDPADPPAAVLAPAA---ALPPAASPAGPLPPPT-SAQPTAPPPPP-GPPPPSLPLGGSVA 2857

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770  493 P----QNLPTSLVTSSQLPLSTPFRANFSESPPLPRATLANRTTPSLQDPLFLAISPPVSSSTSISPPLPTSSVVTPPLR 568
Cdd:PHA03247 2858 PggdvRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPP 2937

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770  569 LPLSQTLPTSQASLLTLPPSLASSPQPATPPPLALSPLSTQLSTGSPSLQASPSflPTPPMQPRALPSPSLQAPPVTYPL 648
Cdd:PHA03247 2938 RPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPAS--STPPLTGHSLSRVSSWASSLALHE 3015

                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 161016770  649 PLSSPPASPPLPALLSPPASPPLESPLSPSASPSSPLATPPPEAPPSLGSPTLSPLATPPP----QTPPLA 715
Cdd:PHA03247 3016 ETDPPPVSLKQTLWPPDDTEDSDADSLFDSDSERSDLEALDPLPPEPHDPFAHEPDPATPEagarESPSSQ 3086
PHA03247 PHA03247
large tegument protein UL36; Provisional
 11-405 4.11e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.48  E-value: 4.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770   11 TAPRMPSSRPPGLLTPRPPSGSARPPPPVTTAALRVLEANGAMGRRSLVERAPGVCKAALPQTSKAALPQTSKAALPQTS 90
Cdd:PHA03247 2715 LVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSES 2794

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770   91 KAALPQTSKAALPQTTIHG-APARSAGAGPRSPANRPPASGKGERAPMKTPGQGSISSPGrassGIARPGPVvqkRLQPP 169
Cdd:PHA03247 2795 RESLPSPWDPADPPAAVLApAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGG----SVAPGGDV---RRRPP 2867

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770  170 TKEPSARGKTPETPK-RNTLNSGTRRVLSADSLGPTSGA--PSPAITRRSRAPATEVGLPQPAPSARQRPLTTEAARKPG 246
Cdd:PHA03247 2868 SRSPAAKPAAPARPPvRRLARPAVSRSTESFALPPDQPErpPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTT 2947

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770  247 SSASEPSATELSPAFRRRSVAGGSLqkPVSRSLIPSATPQLSPSRSGVSPRVTPRAPAHTSQLKSkgqQALHPTQTTVPR 326
Cdd:PHA03247 2948 DPAGAGEPSGAVPQPWLGALVPGRV--AVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASS---LALHEETDPPPV 3022

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 161016770  327 KNKpsvQSLIPASSLVTPTPPGASSVQGPDDPSQTTLPPSPPTTPPLPASLQLLQPQASSQAVPHSQSGqgspsPPPLS 405
Cdd:PHA03247 3023 SLK---QTLWPPDDTEDSDADSLFDSDSERSDLEALDPLPPEPHDPFAHEPDPATPEAGARESPSSQFG-----PPPLS 3093
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
12-215 7.78e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 46.79  E-value: 7.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770   12 APRMPSSRPPGLLTPRPPSGSARPPPPVTTAALRVLEANGAMGRRSLVERAPGVCKAALPQTSKAALPQTSKAALPqtSK 91
Cdd:PRK12323  383 AQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAAAP--AA 460

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770   92 AALPQTSKAALPQTTIHGAPARSAGAGPRSPANR--PPASGKGERAPMKTPGQGSISSPGRASSGIARPGPVVQKRLQPP 169
Cdd:PRK12323  461 AARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDdpPPWEELPPEFASPAPAQPDAAPAGWVAESIPDPATADPDDAFET 540

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 161016770  170 TKEPSARGKTPETPKRNT-LNSGTRRVLSADSLGPTSGAPSPAITRR 215
Cdd:PRK12323  541 LAPAPAAAPAPRAAAATEpVVAPRPPRASASGLPDMFDGDWPALAAR 587
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 11-256 9.04e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 46.70  E-value: 9.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770   11 TAPRMPSSRPPGLLTPRPPSGSARPPPPVTTAALRVLEANGAMGRRSLVERAPGVCKAALPQTSKAALPQTSKAALPQTS 90
Cdd:PHA03307  182 TARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPA 261

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770   91 KAALP---QTSKAALPQTTIHGAPARSAGAGPRSPANRPPASGKGERAPMKTPGQGSISSPGRASSGIARPGPVVQKRLQ 167
Cdd:PHA03307  262 PITLPtriWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAV 341

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770  168 PPTKEPSARGKTPETPKRNTLNSGTRRVLSADSLGPTSGAPSPAITRRSRAPATEVGLPQPAPSARQRPLTTEAARKPGS 247
Cdd:PHA03307  342 SPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAGRPRPSPLDAGA 421


                  ....*....
gi 161016770  248 SASEPSATE 256
Cdd:PHA03307  422 ASGAFYARY 430
PHA03247 PHA03247
large tegument protein UL36; Provisional
 555-988 1.19e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.47  E-value: 1.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770  555 PPLPTSSVVTPPlrlplSQTLPTSQASLLTLPPSLASSPQPATPPPLALSPLSTQLSTGSPSLQASPSFLP---TPPMQP 631
Cdd:PHA03247 2553 PPLPPAAPPAAP-----DRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPpdtHAPDPP 2627

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770  632 RALPSPSLQAPPVTYPLPLSSPPASPPLPALLSPPASPPLESPLSPSASPSSPLATPPPEAPPSLGSptLSPLATPPPQt 711
Cdd:PHA03247 2628 PPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGS--LTSLADPPPP- 2704

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770  712 pPLAFPPLPASTSSLDTATCFPQGPLLALPPLQTSPSPLTIPC----------PQTPPSLALP-SLQSPSSPLATATPPL 780
Cdd:PHA03247 2705 -PPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAgpatpggparPARPPTTAGPpAPAPPAAPAAGPPRRL 2783

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770  781 QIPLVVLPTLQTPPSPLTTFPPGVPPGLTSPVVQPPSPPASPPLQAPRRPPTPGPDVPITGP------------------ 842
Cdd:PHA03247 2784 TRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPpppslplggsvapggdvr 2863

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770  843 -RLTLALAPAPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGCPTISPAPDADLAACHPASWSRSSAPQLA 921
Cdd:PHA03247 2864 rRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPL 2943

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 161016770  922 VRSTPGVPLPWPPTAGPGSSDGLCTIYESEGPESVAPTPGSLDVEPEPMPGSGSAKVTAADCAGASS 988
Cdd:PHA03247 2944 APTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASS 3010
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 8-307 5.34e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 44.39  E-value: 5.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770    8 KSGTAPRMPSSRPPGLLTPRPPSGSARPPPPVTTAALRVLEAngamgrrslverAPGVCKAALPQTSKAALPQTSKAALP 87
Cdd:PHA03307   96 APASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEM------------LRPVGSPGPPPAASPPAAGASPAAVA 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770   88 QTSKAALPQTSKAALPQTTIHGAPARSAGAGPRSPANRPPASGKGERAPMKTPGQGSISSPGRASSGIARPGPVVQKRLQ 167
Cdd:PHA03307  164 SDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSE 243

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770  168 PPTKEPSARGKTPE-TPKRNTLNSGTRRVLSADSLGPTSGAPSPAITRRSRAPATEVGLPQPAPSARQRPLTTEAARKPG 246
Cdd:PHA03307  244 SSGCGWGPENECPLpRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRE 323

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 161016770  247 SSASEPSATELSPafRRRSVAGGSLQKPVSRSLIPSATPQLSPSRSGVSPRVTPRAPAHTS 307
Cdd:PHA03307  324 SSSSSTSSSSESS--RGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASA 382
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
76-287 5.76e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 44.10  E-value: 5.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770   76 AALPQTSKAALPQTSKAALPQTSKAALPQTTIHGAPARSAGAGPRSPANRPPASGKGERAPMKTPGQGSISSPGRASSGI 155
Cdd:PRK12323  372 AGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPA 451

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770  156 ARPGPVVQKRLQPPTKEPSARGKTPETPKRNTLNSGTRRVLSAD-----SLGPTSGAPSPAITRRSRAPATEVGLPQPAP 230
Cdd:PRK12323  452 PAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDpppweELPPEFASPAPAQPDAAPAGWVAESIPDPAT 531

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 161016770  231 SARQRPLTTEAARKPGSSASEPSATELSPAFRRRSVAGGSLQKPVSRSLIPSATPQL 287
Cdd:PRK12323  532 ADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMFDGDWPALAARL 588
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
24-250 1.43e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 42.56  E-value: 1.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770   24 LTPRPPSGSARPPPPvttAALRVLEANGAMGRRSLVERAPgvckaALPQTSKAALPQTSKAALPQTSKAALPQTSKAALP 103
Cdd:PRK12323  363 FRPGQSGGGAGPATA---AAAPVAQPAPAAAAPAAAAPAP-----AAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALA 434

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770  104 QTtiHGAPARSAGAGPRSPANRPPASGKGERAPMKTPGQGSISSPGRASSGIARPGPVVQKRLQPPTKEPSArgkTPETP 183
Cdd:PRK12323  435 AA--RQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPP---EFASP 509

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 161016770  184 KRNTLNSGTRRVLSADSLGPTSGAPSPAitrrsRAPATEVGLPQPAPSARQRPLTTEAARKPGSSAS 250
Cdd:PRK12323  510 APAQPDAAPAGWVAESIPDPATADPDDA-----FETLAPAPAAAPAPRAAAATEPVVAPRPPRASAS 571
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 109-446 1.74e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 42.67  E-value: 1.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770  109 GAPARSAGAGPRSPANRPPASGKGERAPMKTPGQGSISSPGRASSGIARPGPVVQKRLQPPTKEPSARGKTPETPKRNTL 188
Cdd:PRK07764  398 APSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPT 477

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770  189 nsgtrrvlSADSLGPTSGAPSPAITRRSRAPATEVGlPQPAPSARQ-----------RPLTTEAARKPGSSASEPSATEL 257
Cdd:PRK07764  478 --------AAPAPAPPAAPAPAAAPAAPAAPAAPAG-ADDAATLRErwpeilaavpkRSRKTWAILLPEATVLGVRGDTL 548

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770  258 SPAFRR-------------------------------------RSVAGGSLQKPVSRSLIPSATPQLSPSRSGV-----S 295
Cdd:PRK07764  549 VLGFSTgglarrfaspgnaevlvtalaeelggdwqveavvgpaPGAAGGEGPPAPASSGPPEEAARPAAPAAPAapaapA 628

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770  296 PRVTPRAPAHTSQLKSKGQQALHPTQTTVPRknkPSVQSLIPASSLVTPTPPGASSVQGPDDPSQTTLPPSPPTTPPLPA 375
Cdd:PRK07764  629 PAGAAAAPAEASAAPAPGVAAPEHHPKHVAV---PDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAP 705

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 161016770  376 SLQLLQPQASSQAVPHSQSGQGSPSPPPLSLQNLPSTPATPPLLAPPTSLDTEEASDSPPPRAVISSSPPP 446
Cdd:PRK07764  706 AATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPP 776
PHA03247 PHA03247
large tegument protein UL36; Provisional
 586-1007 5.93e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.08  E-value: 5.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770  586 PPSLASSPQPATPPPLALSPLSTQLSTGSPSLQASPSFLPTPPMQPRALPSPSLQAPPvtyplplssppASPPLPALLSP 665
Cdd:PHA03247 2512 PSRLAPAILPDEPVGEPVHPRMLTWIRGLEELASDDAGDPPPPLPPAAPPAAPDRSVP-----------PPRPAPRPSEP 2580

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770  666 PASPPLESPLSPSASPSSPLATPPPEAPPSLGSPTLSPLATPPPQTPPLAFPPLPASTSSLDTATCFPQgpllalPPLQT 745
Cdd:PHA03247 2581 AVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPP------ERPRD 2654

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770  746 SPSPLTIPCPQTPPSLALPSlqSPSSPLATATPPLQIPLVV-LPTLQTPPSPltTFPPGVPPGLTSPVVQPPSPPASPPL 824
Cdd:PHA03247 2655 DPAPGRVSRPRRARRLGRAA--QASSPPQRPRRRAARPTVGsLTSLADPPPP--PPTPEPAPHALVSATPLPPGPAAARQ 2730

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770  825 QAPRRPPTPGPDVPITGPRLTLALAPAPPPPPSRSPSSTLSGPDLAGHSSSATSTPeelrgydSGPEGCPTISPAPDADL 904
Cdd:PHA03247 2731 ASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRP-------AVASLSESRESLPSPWD 2803

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770  905 AACHPASWSrSSAPQLAVRSTPGVPLPWPPTAGPGSSdglctiyesegPESVAPTPGSLDVEPEPMPGSGSAKVTAADCA 984
Cdd:PHA03247 2804 PADPPAAVL-APAAALPPAASPAGPLPPPTSAQPTAP-----------PPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSP 2871

                         410       420
                  ....*....|....*....|...
gi 161016770  985 GASSRSPKSARLGELPLGALQAS 1007
Cdd:PHA03247 2872 AAKPAAPARPPVRRLARPAVSRS 2894
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 381-779 6.77e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.52  E-value: 6.77e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770   381 QPQASSQAVPHSQSGQGSPSPPPLSLQNLPSTPATPPLLAPPTSLDTEEASDSPPPRAVISSSPP-PLIQNMPPNQASSA 459
Cdd:pfam03154  163 QQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPhTLIQQTPTLHPQRL 242

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770   460 TLPQETLSAMPFSPAPlslassppqllpsPPISPQNLPTSLVTSSQLPLSTPFRANFSESPPLPRATLANRTTPSLQDPL 539
Cdd:pfam03154  243 PSPHPPLQPMTQPPPP-------------SQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQV 309

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770   540 FLAISPPVSSSTSISPPLPTSSVVTPPLRLPLSQTLPTSQASLL------TLPPSLASSPQPATPPPLALSPLSTQLSTG 613
Cdd:pfam03154  310 PPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPhikpppTTPIPQLPNPQSHKHPPHLSGPSPFQMNSN 389

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770   614 SPSLQASPSFLPTPPMQPRALPSPSLQAPPvtYPLPLSSPPASPPLPALLSPPASPPLESPLSPSASPSSPLATPPPEAP 693
Cdd:pfam03154  390 LPPPPALKPLSSLSTHHPPSAHPPPLQLMP--QSQQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPF 467

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016770   694 PSLGSPTLSPLATPPPQTPPLAFPPLPASTSSLDTATCFPQGPLLALPPLQTSPSPLTIP-CPQTPPslalPSLQSPSSP 772
Cdd:pfam03154  468 VPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVSCPLPPVQIKEEALDEAeEPESPP----PPPRSPSPE 543


                   ....*..
gi 161016770   773 LATATPP 779
Cdd:pfam03154  544 PTVVNTP 550
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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