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Conserved domains on  [gi|289666758|ref|NP_997208|]
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protein C-mannosyl-transferase DPY19L3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Dpy19L3 cd20181
C-mannosyltransferase Dpy-19-like protein 3 (Dpy19L3); Dpy19 proteins are ...
46-712 0e+00

C-mannosyltransferase Dpy-19-like protein 3 (Dpy19L3); Dpy19 proteins are C-mannosyltransferases that mediate C-mannosylation of tryptophan residues on target proteins. C-mannosylation is the attachment of alpha-mannose to the indole C2 carbon of the first tryptophan residue in the consensus amino acid sequence Trp-Xaa-Xaa-Trp/Cys through a C-C bond. This reaction takes place in the endoplasmic reticulum (ER) lumen. Dpy19 is a transmembrane domain family whose name is derived from the Caenorhabditis elegans Dumpy mutant. In humans Dpy19L3 (also called protein Dpy-19 homolog 3) is a C-mannosyltransferase of R-spondin.


:

Pssm-ID: 439134  Cd Length: 667  Bit Score: 1271.69  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758  46 SLTIGGTIALCIGLLTSVYLATLHENDLWFSNIKEVEREISFRTECGLYYSYYKQMLQAPTLVQGFHGLIYDNKTESMKT 125
Cdd:cd20181    1 STTVGGTVALCIGLLTSVYVATLHENDLWFSNIKEVEREISFRTECGLYYSYYKQMLQAPSIQQGFHGLIYDNKTESMRT 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758 126 INLLQRMNIYQEVFLSILYRVLPIQKYLEPVYFYIYTLFGLQAIYVTALYITSWLLSGTWLSGLLAAFWYVTNRIDTTRV 205
Cdd:cd20181   81 INLLQRMNIYQEVFLSVLYRVLPIQKYLEPVYFYIYTLFGLQAVYVIALYITSWLLSGTWLSGLLAAVWYITNRIDTTRV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758 206 EFTIPLRENWALPFFAIQIAAITYFLRPNLQPLSERLTLLAIFISTFLFSLTWQFNQFMMLMQALVLFTLDSLDMLPAVK 285
Cdd:cd20181  161 EFTIPLRENWALPFFAIQIAAITYFLRPNLQPLQERLTLLAIFISTFLFSLTWQFNQFMMLIQALVLFTLDCLDMLPTAK 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758 286 ATWLYGIQITSLLLVCILQFFNSMILGSLLISFNLSVFIARKLQKNLKTGSFLNRLGKLLLHLFMVLCLTLFLNNIIKKI 365
Cdd:cd20181  241 VTWLYGIQISGLLLVCILQFFNSMILGSLLLSFNLSVLIVRKLQKNLKTGSFLNRLGKLLLHLALVLCLTLFLNNIIKKI 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758 366 LNLKSDEHIFKFLKAKFGLGATRDFDANLYLCEEAFGLLPFNTFGRLSDTLLFYAYIFVLSITVIVAFVVAFHNLSDSTN 445
Cdd:cd20181  321 LNLKSDEHIFKFLKAKFGFGATRDFDANLYLCEEAFGLLPFNTFERLSDTLLFYAYIFVLLLTVIVAAVVAFHNLSDSTN 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758 446 QQSVGKMEKGTVDLKPETAYNLIHTILFGFLALSTMRMKYLWTSHMCVFASFGLCSPEIWELLLKSVHLYNPKRICIMRY 525
Cdd:cd20181  401 QQSMGKMEKGTVDLKPEVAYNLIHTILFGFLALSTMRMKYLWTSHMCVFASFGLCSTELWELLLKSVHLYNPKRIRVMRY 480
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758 526 SVPILILLYLCYKFWPGMMDELSELREFYDPDTVELMNWINSNTPRKAVFAGSMQLLAGVKLCTGRTLTNHPHYEDSSLR 605
Cdd:cd20181  481 SVPILTLLYLCYKFWPGLMDELSELREFYDPDTVELMNWINSNTPRKAVFAGSMQLLAGVKLCTGRTLTNHPHYEDKSLR 560
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758 606 ERTRAVYQIYAKRAPEEVHALLRSFGTDYVILEDSICYERRHRRGCRLRDLLDIANGHMMDGPGENDPDLKPADHPRFCE 685
Cdd:cd20181  561 ERTRQVYQIYAKRSPEEVHALLRSFGTDYVILEDSICYERRHRRGCRLRDLLDIANGHIMDGPGENDPDLKPADHPRFCE 640
                        650       660
                 ....*....|....*....|....*..
gi 289666758 686 EIKRNLPPYVAYFTRVFQNKTFHVYKL 712
Cdd:cd20181  641 EIKRNLPSYAAYFTRVFQNKTFHVYKL 667
 
Name Accession Description Interval E-value
Dpy19L3 cd20181
C-mannosyltransferase Dpy-19-like protein 3 (Dpy19L3); Dpy19 proteins are ...
46-712 0e+00

C-mannosyltransferase Dpy-19-like protein 3 (Dpy19L3); Dpy19 proteins are C-mannosyltransferases that mediate C-mannosylation of tryptophan residues on target proteins. C-mannosylation is the attachment of alpha-mannose to the indole C2 carbon of the first tryptophan residue in the consensus amino acid sequence Trp-Xaa-Xaa-Trp/Cys through a C-C bond. This reaction takes place in the endoplasmic reticulum (ER) lumen. Dpy19 is a transmembrane domain family whose name is derived from the Caenorhabditis elegans Dumpy mutant. In humans Dpy19L3 (also called protein Dpy-19 homolog 3) is a C-mannosyltransferase of R-spondin.


Pssm-ID: 439134  Cd Length: 667  Bit Score: 1271.69  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758  46 SLTIGGTIALCIGLLTSVYLATLHENDLWFSNIKEVEREISFRTECGLYYSYYKQMLQAPTLVQGFHGLIYDNKTESMKT 125
Cdd:cd20181    1 STTVGGTVALCIGLLTSVYVATLHENDLWFSNIKEVEREISFRTECGLYYSYYKQMLQAPSIQQGFHGLIYDNKTESMRT 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758 126 INLLQRMNIYQEVFLSILYRVLPIQKYLEPVYFYIYTLFGLQAIYVTALYITSWLLSGTWLSGLLAAFWYVTNRIDTTRV 205
Cdd:cd20181   81 INLLQRMNIYQEVFLSVLYRVLPIQKYLEPVYFYIYTLFGLQAVYVIALYITSWLLSGTWLSGLLAAVWYITNRIDTTRV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758 206 EFTIPLRENWALPFFAIQIAAITYFLRPNLQPLSERLTLLAIFISTFLFSLTWQFNQFMMLMQALVLFTLDSLDMLPAVK 285
Cdd:cd20181  161 EFTIPLRENWALPFFAIQIAAITYFLRPNLQPLQERLTLLAIFISTFLFSLTWQFNQFMMLIQALVLFTLDCLDMLPTAK 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758 286 ATWLYGIQITSLLLVCILQFFNSMILGSLLISFNLSVFIARKLQKNLKTGSFLNRLGKLLLHLFMVLCLTLFLNNIIKKI 365
Cdd:cd20181  241 VTWLYGIQISGLLLVCILQFFNSMILGSLLLSFNLSVLIVRKLQKNLKTGSFLNRLGKLLLHLALVLCLTLFLNNIIKKI 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758 366 LNLKSDEHIFKFLKAKFGLGATRDFDANLYLCEEAFGLLPFNTFGRLSDTLLFYAYIFVLSITVIVAFVVAFHNLSDSTN 445
Cdd:cd20181  321 LNLKSDEHIFKFLKAKFGFGATRDFDANLYLCEEAFGLLPFNTFERLSDTLLFYAYIFVLLLTVIVAAVVAFHNLSDSTN 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758 446 QQSVGKMEKGTVDLKPETAYNLIHTILFGFLALSTMRMKYLWTSHMCVFASFGLCSPEIWELLLKSVHLYNPKRICIMRY 525
Cdd:cd20181  401 QQSMGKMEKGTVDLKPEVAYNLIHTILFGFLALSTMRMKYLWTSHMCVFASFGLCSTELWELLLKSVHLYNPKRIRVMRY 480
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758 526 SVPILILLYLCYKFWPGMMDELSELREFYDPDTVELMNWINSNTPRKAVFAGSMQLLAGVKLCTGRTLTNHPHYEDSSLR 605
Cdd:cd20181  481 SVPILTLLYLCYKFWPGLMDELSELREFYDPDTVELMNWINSNTPRKAVFAGSMQLLAGVKLCTGRTLTNHPHYEDKSLR 560
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758 606 ERTRAVYQIYAKRAPEEVHALLRSFGTDYVILEDSICYERRHRRGCRLRDLLDIANGHMMDGPGENDPDLKPADHPRFCE 685
Cdd:cd20181  561 ERTRQVYQIYAKRSPEEVHALLRSFGTDYVILEDSICYERRHRRGCRLRDLLDIANGHIMDGPGENDPDLKPADHPRFCE 640
                        650       660
                 ....*....|....*....|....*..
gi 289666758 686 EIKRNLPPYVAYFTRVFQNKTFHVYKL 712
Cdd:cd20181  641 EIKRNLPSYAAYFTRVFQNKTFHVYKL 667
Dpy19 pfam10034
Q-cell neuroblast polarization; Dyp-19, formerly known as DUF2211, is a transmembrane domain ...
55-712 0e+00

Q-cell neuroblast polarization; Dyp-19, formerly known as DUF2211, is a transmembrane domain family that is required to orient the neuroblast cells, QR and QL accurately on the anterior-posterior axis: QL and QR are born in the same anterior-posterior position, but polarise and migrate left-right asymmetrically, QL migrating towards the posterior and QR migrating towards the anterior. It is also required, with unc-40, to express mab-5 correctly in the Q cell descendants. The Dpy-19 protein derives from the C. elegans DUMPY mutant, Swiss:P34413.


Pssm-ID: 462945  Cd Length: 646  Bit Score: 866.15  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758   55 LCIGLLTSVYLATLHENDLWFSNIKEVEREISFRTECGLYYSYYKQMLQAPTLVQGFHGLIYDNKTESMKTINLLQRMNI 134
Cdd:pfam10034   1 VGSGILYALHVSTLFENDRWFSHLSELEREISFRTEMGLYYSYYKTIIEAPSFLEGLYQLMNDNRTEYPDTINALQRFNL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758  135 YQEVFLSILYRVLP-IQKYL-EPVYFYIYTLFGLQAIYVTALYITSWLLSGTWLSGLLAAFWYVTNRIDTTRVEFTIPLR 212
Cdd:pfam10034  81 YPEVILAILYRIFRgIQNYLgEPVYFYIYFVFGLQGVYVSALFLYGWYLSGSWLGGILAVLWFFFNHGETTRVEWTPPLR 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758  213 ENWALPFFAIQIAAITYFLRP-NLQPLSERLTLLAIFISTFLFSLTWQFNQFMMLMQALVLFTLDSLDMLPAVKATWLYG 291
Cdd:pfam10034 161 ENFALPFFALQMLALTYILKRkNISSASELFCYILLSASTFLFLLTWQFSQFVLLTQILSLFLLDSLGLVPSKKVAKIYL 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758  292 IQITSLLLVCILQFFNSMILGSLLISFNLSVFIARKLQKNLKTGSFLNRLGKLLLHLFMVLCLTLFLNNIIKKILNLKSD 371
Cdd:pfam10034 241 SHLISLLLAFVLQFGNSMLLTSPLLSSLISILLIRYLQPNMKKGRFSFRLLKLLLHGLLVLFGTLTLKLLIKKLLNVEDD 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758  372 EHIFKFLKAKFGLGATRDFDANLYLCEEAFGLLPFNTFGRLSDTLLFYAYIFVLSITVIVAFVVAFHNL----SDSTNQQ 447
Cdd:pfam10034 321 AHIFDFLKAKFGLNSTRDFDTNLYTCAEEFDFLSKETFLRLTKTLLLPFYILVLLILLIKVLQSIYRRLkrykLSQAPMQ 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758  448 SVGKMEKGTVDLKPET----AYNLIHTILFGFLALSTMRMKYLWTSHMCVFASFGlCSPEIWELLLKsvhlynpkriCIM 523
Cdd:pfam10034 401 ESLPLEDGRIGERPELngevVYHVLQLLAFGLLALLIMRLKLLWTPHMCVFASLG-ASKQLWHFLFK----------KIF 469
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758  524 RYSVPILILLYLCYKFWPGMMDELSELREFYDPDTVELMNWINSNTPRKAVFAGSMQLLAGVKLCTGRTLTNHPHYEDSS 603
Cdd:pfam10034 470 SSAVPTVILASMSYKGFPNIQEELSILGEFYNPDTEELMEWIKSNTPKDAVFAGSMPLMATVKLSTGRPIVNHPHYEDAG 549
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758  604 LRERTRAVYQIYAKRAPEEVHALLRSFGTDYVILEDSICYERRHRRGCRLRDLLDIANGHmmdgpgendpDLKPADHPRF 683
Cdd:pfam10034 550 LRERTEDVYSVYSRKPAEDVYKILTSLKVNYVILEDSICSERSRRRGCRMLDIWDVEDGH----------CPANRKGPRF 619
                         650       660
                  ....*....|....*....|....*....
gi 289666758  684 CEEIKrnLPPYVAYFTRVFQNKTFHVYKL 712
Cdd:pfam10034 620 CHEIK--LSNYVPYFTRVFWNRSYHVYKV 646
 
Name Accession Description Interval E-value
Dpy19L3 cd20181
C-mannosyltransferase Dpy-19-like protein 3 (Dpy19L3); Dpy19 proteins are ...
46-712 0e+00

C-mannosyltransferase Dpy-19-like protein 3 (Dpy19L3); Dpy19 proteins are C-mannosyltransferases that mediate C-mannosylation of tryptophan residues on target proteins. C-mannosylation is the attachment of alpha-mannose to the indole C2 carbon of the first tryptophan residue in the consensus amino acid sequence Trp-Xaa-Xaa-Trp/Cys through a C-C bond. This reaction takes place in the endoplasmic reticulum (ER) lumen. Dpy19 is a transmembrane domain family whose name is derived from the Caenorhabditis elegans Dumpy mutant. In humans Dpy19L3 (also called protein Dpy-19 homolog 3) is a C-mannosyltransferase of R-spondin.


Pssm-ID: 439134  Cd Length: 667  Bit Score: 1271.69  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758  46 SLTIGGTIALCIGLLTSVYLATLHENDLWFSNIKEVEREISFRTECGLYYSYYKQMLQAPTLVQGFHGLIYDNKTESMKT 125
Cdd:cd20181    1 STTVGGTVALCIGLLTSVYVATLHENDLWFSNIKEVEREISFRTECGLYYSYYKQMLQAPSIQQGFHGLIYDNKTESMRT 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758 126 INLLQRMNIYQEVFLSILYRVLPIQKYLEPVYFYIYTLFGLQAIYVTALYITSWLLSGTWLSGLLAAFWYVTNRIDTTRV 205
Cdd:cd20181   81 INLLQRMNIYQEVFLSVLYRVLPIQKYLEPVYFYIYTLFGLQAVYVIALYITSWLLSGTWLSGLLAAVWYITNRIDTTRV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758 206 EFTIPLRENWALPFFAIQIAAITYFLRPNLQPLSERLTLLAIFISTFLFSLTWQFNQFMMLMQALVLFTLDSLDMLPAVK 285
Cdd:cd20181  161 EFTIPLRENWALPFFAIQIAAITYFLRPNLQPLQERLTLLAIFISTFLFSLTWQFNQFMMLIQALVLFTLDCLDMLPTAK 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758 286 ATWLYGIQITSLLLVCILQFFNSMILGSLLISFNLSVFIARKLQKNLKTGSFLNRLGKLLLHLFMVLCLTLFLNNIIKKI 365
Cdd:cd20181  241 VTWLYGIQISGLLLVCILQFFNSMILGSLLLSFNLSVLIVRKLQKNLKTGSFLNRLGKLLLHLALVLCLTLFLNNIIKKI 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758 366 LNLKSDEHIFKFLKAKFGLGATRDFDANLYLCEEAFGLLPFNTFGRLSDTLLFYAYIFVLSITVIVAFVVAFHNLSDSTN 445
Cdd:cd20181  321 LNLKSDEHIFKFLKAKFGFGATRDFDANLYLCEEAFGLLPFNTFERLSDTLLFYAYIFVLLLTVIVAAVVAFHNLSDSTN 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758 446 QQSVGKMEKGTVDLKPETAYNLIHTILFGFLALSTMRMKYLWTSHMCVFASFGLCSPEIWELLLKSVHLYNPKRICIMRY 525
Cdd:cd20181  401 QQSMGKMEKGTVDLKPEVAYNLIHTILFGFLALSTMRMKYLWTSHMCVFASFGLCSTELWELLLKSVHLYNPKRIRVMRY 480
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758 526 SVPILILLYLCYKFWPGMMDELSELREFYDPDTVELMNWINSNTPRKAVFAGSMQLLAGVKLCTGRTLTNHPHYEDSSLR 605
Cdd:cd20181  481 SVPILTLLYLCYKFWPGLMDELSELREFYDPDTVELMNWINSNTPRKAVFAGSMQLLAGVKLCTGRTLTNHPHYEDKSLR 560
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758 606 ERTRAVYQIYAKRAPEEVHALLRSFGTDYVILEDSICYERRHRRGCRLRDLLDIANGHMMDGPGENDPDLKPADHPRFCE 685
Cdd:cd20181  561 ERTRQVYQIYAKRSPEEVHALLRSFGTDYVILEDSICYERRHRRGCRLRDLLDIANGHIMDGPGENDPDLKPADHPRFCE 640
                        650       660
                 ....*....|....*....|....*..
gi 289666758 686 EIKRNLPPYVAYFTRVFQNKTFHVYKL 712
Cdd:cd20181  641 EIKRNLPSYAAYFTRVFQNKTFHVYKL 667
Dpy19 pfam10034
Q-cell neuroblast polarization; Dyp-19, formerly known as DUF2211, is a transmembrane domain ...
55-712 0e+00

Q-cell neuroblast polarization; Dyp-19, formerly known as DUF2211, is a transmembrane domain family that is required to orient the neuroblast cells, QR and QL accurately on the anterior-posterior axis: QL and QR are born in the same anterior-posterior position, but polarise and migrate left-right asymmetrically, QL migrating towards the posterior and QR migrating towards the anterior. It is also required, with unc-40, to express mab-5 correctly in the Q cell descendants. The Dpy-19 protein derives from the C. elegans DUMPY mutant, Swiss:P34413.


Pssm-ID: 462945  Cd Length: 646  Bit Score: 866.15  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758   55 LCIGLLTSVYLATLHENDLWFSNIKEVEREISFRTECGLYYSYYKQMLQAPTLVQGFHGLIYDNKTESMKTINLLQRMNI 134
Cdd:pfam10034   1 VGSGILYALHVSTLFENDRWFSHLSELEREISFRTEMGLYYSYYKTIIEAPSFLEGLYQLMNDNRTEYPDTINALQRFNL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758  135 YQEVFLSILYRVLP-IQKYL-EPVYFYIYTLFGLQAIYVTALYITSWLLSGTWLSGLLAAFWYVTNRIDTTRVEFTIPLR 212
Cdd:pfam10034  81 YPEVILAILYRIFRgIQNYLgEPVYFYIYFVFGLQGVYVSALFLYGWYLSGSWLGGILAVLWFFFNHGETTRVEWTPPLR 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758  213 ENWALPFFAIQIAAITYFLRP-NLQPLSERLTLLAIFISTFLFSLTWQFNQFMMLMQALVLFTLDSLDMLPAVKATWLYG 291
Cdd:pfam10034 161 ENFALPFFALQMLALTYILKRkNISSASELFCYILLSASTFLFLLTWQFSQFVLLTQILSLFLLDSLGLVPSKKVAKIYL 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758  292 IQITSLLLVCILQFFNSMILGSLLISFNLSVFIARKLQKNLKTGSFLNRLGKLLLHLFMVLCLTLFLNNIIKKILNLKSD 371
Cdd:pfam10034 241 SHLISLLLAFVLQFGNSMLLTSPLLSSLISILLIRYLQPNMKKGRFSFRLLKLLLHGLLVLFGTLTLKLLIKKLLNVEDD 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758  372 EHIFKFLKAKFGLGATRDFDANLYLCEEAFGLLPFNTFGRLSDTLLFYAYIFVLSITVIVAFVVAFHNL----SDSTNQQ 447
Cdd:pfam10034 321 AHIFDFLKAKFGLNSTRDFDTNLYTCAEEFDFLSKETFLRLTKTLLLPFYILVLLILLIKVLQSIYRRLkrykLSQAPMQ 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758  448 SVGKMEKGTVDLKPET----AYNLIHTILFGFLALSTMRMKYLWTSHMCVFASFGlCSPEIWELLLKsvhlynpkriCIM 523
Cdd:pfam10034 401 ESLPLEDGRIGERPELngevVYHVLQLLAFGLLALLIMRLKLLWTPHMCVFASLG-ASKQLWHFLFK----------KIF 469
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758  524 RYSVPILILLYLCYKFWPGMMDELSELREFYDPDTVELMNWINSNTPRKAVFAGSMQLLAGVKLCTGRTLTNHPHYEDSS 603
Cdd:pfam10034 470 SSAVPTVILASMSYKGFPNIQEELSILGEFYNPDTEELMEWIKSNTPKDAVFAGSMPLMATVKLSTGRPIVNHPHYEDAG 549
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758  604 LRERTRAVYQIYAKRAPEEVHALLRSFGTDYVILEDSICYERRHRRGCRLRDLLDIANGHmmdgpgendpDLKPADHPRF 683
Cdd:pfam10034 550 LRERTEDVYSVYSRKPAEDVYKILTSLKVNYVILEDSICSERSRRRGCRMLDIWDVEDGH----------CPANRKGPRF 619
                         650       660
                  ....*....|....*....|....*....
gi 289666758  684 CEEIKrnLPPYVAYFTRVFQNKTFHVYKL 712
Cdd:pfam10034 620 CHEIK--LSNYVPYFTRVFWNRSYHVYKV 646
Dpy19 cd20177
C-mannosyltransferase Dpy19; Dpy19 proteins are C-mannosyltransferases that mediate ...
46-709 0e+00

C-mannosyltransferase Dpy19; Dpy19 proteins are C-mannosyltransferases that mediate C-mannosylation of tryptophan residues on target proteins. C-mannosylation is the attachment of alpha-mannose to the indole C2 carbon of the first tryptophan residue in the consensus amino acid sequence Trp-Xaa-Xaa-Trp/Cys through a C-C bond. This reaction takes place in the endoplasmic reticulum (ER) lumen. Dpy19 is a transmembrane domain family whose name is derived from the Caenorhabditis elegans Dumpy mutant.


Pssm-ID: 439130  Cd Length: 657  Bit Score: 807.64  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758  46 SLTIGGTIALCIGLLTSVYLATLHENDLWFSNIKEVEREISFRTECGLYYSYYKQMLQAPTLVQGFHGLIYDNKTESMKT 125
Cdd:cd20177    1 KILLGLLLALLVGVLYSLHLSTLFENDRHFSHLSELEREMTFRTEMGLYYSYYKQLIEAPSFLEGLYKLTHDNVTEYPHT 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758 126 INLLQRMNIYQEVFLSILYRVLPIQK--------------------------YLEPVYFYIYTLFGLQAIYVTALYITSW 179
Cdd:cd20177   81 INTLKRFNLYPEVILAILYRVFPSIAnyfgiptkqcwqvrgedlppvescegLGEPAYFYIYVVFGLNGLVAGLLFLYGW 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758 180 LLSGTWLSGLLAAFWYVTNRIDTTRVEFTIPLRENWALPFFAIQIAAITYFLRPNLqplSERLTLLAIFISTFLFSLTWQ 259
Cdd:cd20177  161 LLSGSILGGLLTVAFFFFNHGEATRVQWTPPLRESFAYPFLLLQILLITIYLRSNI---GKRFHLLAISISTFLFMLMWQ 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758 260 FNQFMMLMQALVLFTLDSLDMLPAVKATWLYGIQITSLLLVCILQFFNSMILGSLLISFNLSVFIARKLQKNLKTgSFLN 339
Cdd:cd20177  238 FSQFALLTQILSLFALYVLGYIPSSKVQTIILSHLISLLLAFVLLFGNEMLLTSLYLSSLLAFLIILYLQLRLKK-SFKF 316
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758 340 RLGKLLLHLFMVLCLTLFLNNIIKKILNLKSDEHIFKFLKAKFGLGatRDFDANLYLCEEAFGLLPFNTFGRLSDTLLFY 419
Cdd:cd20177  317 KLIIWLLQLILVFLGTLGLKLLLSKLLNVEDDAHIFKILKSKFGDY--RDFDTRLYTCAAEFDFLSLETFLRLSKTLLLP 394
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758 420 AYIFVLSITVIVAFVVAFHNLSDSTNQQSVgKMEKGTVDLKPETAYNLIHTILFGFLALSTMRMKYLWTSHMCVFASFGL 499
Cdd:cd20177  395 LYIVVLVVIAFLFLRVRLLTLNDSTLKESV-NFTDSRLILNPEIVYNVLQLLAFGLLAILIMRLKLFWTPHMCILASLLL 473
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758 500 CSPEIWELLLKSvhlynpkricIMRYSVPILILLYLCYKFWPGMMDELSELREFYDPDTVELMNWINSNTPRKAVFAGSM 579
Cdd:cd20177  474 SKKLLWKLLLKK----------IFRLAVLFALLASMSYPGIPNLQEELSILGEFSNPDTEELMEWIKDNTPPDAVFAGSM 543
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758 580 QLLAGVKLCTGRTLTNHPHYEDSSLRERTRAVYQIYAKRAPEEVHALLRSFGTDYVILEDSICYErRHRRGCRLRDLLDI 659
Cdd:cd20177  544 PLMANVKLSTGRPIVNHPHYEDAGLRERTKQVYSMYSRRPAEEVYNILKKLGVNYIILEDSICLS-RRRDGCSLPDIWDL 622
                        650       660       670       680       690
                 ....*....|....*....|....*....|....*....|....*....|
gi 289666758 660 ANGHMMDGPGendpdlkpadhprfcEEIKRNLPPYVAYFTRVFQNKTFHV 709
Cdd:cd20177  623 EDPHNRGKPP---------------LCIRLLLEDYVPYFKLVFSNKTYRV 657
Dpy19L4 cd20180
C-mannosyltransferase Dpy-19-like protein 4 (Dpy19L4); Dpy19 proteins are ...
47-711 0e+00

C-mannosyltransferase Dpy-19-like protein 4 (Dpy19L4); Dpy19 proteins are C-mannosyltransferases that mediate C-mannosylation of tryptophan residues on target proteins. C-mannosylation is the attachment of alpha-mannose to the indole C2 carbon of the first tryptophan residue in the consensus amino acid sequence Trp-Xaa-Xaa-Trp/Cys through a C-C bond. This reaction takes place in the endoplasmic reticulum (ER) lumen. Dpy19 is a transmembrane domain family whose name is derived from the Caenorhabditis elegans Dumpy mutant. The function of Dpy19L4 (also called protein Dpy-19 homolog 4) is unknown.


Pssm-ID: 439133  Cd Length: 664  Bit Score: 609.15  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758  47 LTIGGTIALCIGLLTSVYLATLHENDLWFSNIKEVEREISFRTECGLYYSYYKQMLQAPTLVQGFHGLIYDNKTESMKTI 126
Cdd:cd20180    2 IFFGCLAAVTSGMMYAVYLSTYHERKFWFSNRQELEREITFQGDSAIYYSYYKDMLKAPSFERGVYELTHNNKTVSLKTI 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758 127 NLLQRMNIYQEVFLSILYRVLPIQKYLEPVYFYIYTLFGLQAIYVTALYITSWLLSGTWLSGLLAAFWYVTNRIDTTRVE 206
Cdd:cd20180   82 NAVQQMSLYPELIASVLYQATGSNEVIEPVYFYIGIVFGLQGIYVTALFVTSWLMSGTWLAGMLTVAWFIINRVDTTRIE 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758 207 FTIPLRENWALPFFAIQIAAITYFLRPNLQPLSERLTLLAIFISTFLFSLTWQFNQFMMLMQALVLFTLDSLDMLPAVKA 286
Cdd:cd20180  162 YSIPLRENWALPYFACQVAALTGYLKSNLNTYAERFCYLLMSASTYTFMMMWEYSHYVLFLQAISLFLLDSFSLEQSDKV 241
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758 287 TWLYGIQITSLLLVCILQFFNSMILGSLLISFNLSVFIARKLQKNLKTGSFLNRLgKLLLHLFMVLCLTLFLNNIIKKIL 366
Cdd:cd20180  242 YEVYKVYLFSLFLGYLLQFENPALLVSPLLSLVAALMLAKCLQLNMKKGPFVAKM-IKVLHFYLVCTLTITLNFIMKMFV 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758 367 NLKSDEHIFKFLKAKFGLGATRDFDANLYLCEEAFGLLPFNTFGRLSDTLLFYAYIFVLSITVIVAFVVAFHNLSDSTNQ 446
Cdd:cd20180  321 PHKENEHLLKFLEVKFGLNTTKNFTMNWLLCQESLQAPSQDFFLRLTQSSLLPFYILVLIICLLSMLQVIFRRLSGKPLK 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758 447 QSVgKMEKGTVDLKPETAYNLIHTILFGFLALSTMRMKYLWTSHMCVFASFGLCSPEIWELLLKSVHLYNPKRIC---IM 523
Cdd:cd20180  401 ETV-TLEDGRIGERPEIVYHVIHTILLGSLAMLFEGMKYLWTPYVCMLAAFGVCSPELWMTLFKWLRLRTVHPILlalIL 479
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758 524 RYSVPILILLYLCYKFWPGMMDELSELREFYDPDTVELMNWINSNTPRKAVFAGSMQLLAGVKLCTGRTLTNHPHYEDSS 603
Cdd:cd20180  480 SMAVPTIIGFSLWKEFFPRLMTELSELQEFYDPDTVELMTWIKRQAPVAAVFAGSPQLMGTIKLCTGWMVTSLPLYNDDD 559
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758 604 LRERTRAVYQIYAKRAPEEVHALLRSFGTDYVILEDSICYERRHRRGCRLRDLLDIANGHMMDGPGENdpdLKPADHPRF 683
Cdd:cd20180  560 LLKRNENIYQIYSKRSAEDIYKILTSYKANYLIIEDAICNEVGPVRGCRVKDLLDIANGHVVCEEGDK---YTYSKYGRF 636
                        650       660
                 ....*....|....*....|....*...
gi 289666758 684 CEEIKRNLPPYVAYFTRVFQNKTFHVYK 711
Cdd:cd20180  637 CHEIKINYSPYVNYFTRVYWNRSYFVYK 664
Dpy19L1 cd20178
C-mannosyltransferase Dpy-19-like protein 1 (Dpy19L1); Dpy19 proteins are ...
53-709 1.06e-88

C-mannosyltransferase Dpy-19-like protein 1 (Dpy19L1); Dpy19 proteins are C-mannosyltransferases that mediate C-mannosylation of tryptophan residues on target proteins. C-mannosylation is the attachment of alpha-mannose to the indole C2 carbon of the first tryptophan residue in the consensus amino acid sequence Trp-Xaa-Xaa-Trp/Cys through a C-C bond. This reaction takes place in the endoplasmic reticulum (ER) lumen. Dpy19 is a transmembrane domain family whose name is derived from the Caenorhabditis elegans Dumpy mutant. Dpy19L1 (also called protein Dpy-19 homolog 1) regulates neurite extension during development.


Pssm-ID: 439131  Cd Length: 652  Bit Score: 291.37  E-value: 1.06e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758  53 IALCIGLLTSVYLATLHENDLWFSNIKEVEREISFRTECGLYYSYYKQMLQAPTLVQGFHGLIYDNKTESMKTINLLQRM 132
Cdd:cd20178    8 LAALAGVLHWSHITHLFENDRHFSHLSTLEREMAFRTEMGLYYSYFKTIIEAPSFLNGVWMIMNDRLTEYPLVINTLKRF 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758 133 NIYQEVFLSILYRV-------LPIQ----------KYLEPV----------YFYIYTLFGLQAIYVTALYITSWLLSGTW 185
Cdd:cd20178   88 NLYPEVVLASWYRIytgimdfFGIQtktcwtvnrgEGLSPVesceglgdpaYFYVAVIFLLNGLMMSLFFIYGTYLSGSR 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758 186 LSGLLAAFWYVTNRIDTTRVEFTIPLRENWALPFFAIQIAAITYFLRpnlQPLSERLTLLAIFISTFLFSLTWQFNQFMM 265
Cdd:cd20178  168 LGGVVTVLCFFFNHGECTRVMWTPPLRESFSYPFLVLQMLLVTYILR---APNLGRGSLIALCISNVLFMLPWQFAQFVL 244
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758 266 LMQALVLFTLDSLDMLPAVKATWLYGIQITSLLLVCILQFFNSMILGSLLISFNLSVFIARKLQKNLkTGSFLNRLGKLL 345
Cdd:cd20178  245 LTQIASLFAVYVVGYIDSCKLQKILYAHMISLVVCFVLMFGNSMLLTSYYASSLVIIWGILALRPKF-LKVNKSEVSLWV 323
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758 346 LHLFMVLCLTLFLNNIIKKILNLKSDEHIFKFLKAKFglGATRDFDANLYLCEEAFGLLPFNTFGRLSDTLLFYAYIFVL 425
Cdd:cd20178  324 IQGCAWLFGTVILKYLTSKVFGIADDAHIGNLLKSKF--TSYKDFDTLMYTCAAEFDFMEKETPLRYTKTLLLPVVLVVF 401
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758 426 SITVIVAFVVAFHNLSDSTNQQSVGKMEKGtvdlkpETAYNLIHTILFGFLALSTMRMKYLWTSHMCVFASFgLCSPEIW 505
Cdd:cd20178  402 AAIARKTIKDLWGVLAKKATHTRKEQFAHG------ELVYHALQLLAYAVLAILIMRLKLFLTPHMCVMASL-VCSRQLF 474
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758 506 ELLLKSVHlynpkricimRYSVPILILLYLCYKFWPGMMDELSELREFYDPDTVELMNWINSNTPRKAVFAGSMQLLAGV 585
Cdd:cd20178  475 GWLFCKVH----------PQAVVFAILAAMAIQGSANLQTQWNIIGEFSNLPQEELLEWIKYNTKPDAVFAGAMPTMASV 544
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758 586 KLCTGRTLTNHPHYEDSSLRERTRAVYQIYAKRAPEEVHALLRSFGTDYVILEDSICYERRHrrgcrlrdlldianghmm 665
Cdd:cd20178  545 KLSALRPIVNHPHYEDAGLRARTKIVYSMYSRKPAEEVKRELMKLGVNYYILEESWCVRRSK------------------ 606
                        650       660       670       680       690
                 ....*....|....*....|....*....|....*....|....*....|
gi 289666758 666 dgPGENDPDLKPADHPR------FCEEIKRNLPPyvaYFTRVFQNKTFHV 709
Cdd:cd20178  607 --PGCSMPEIWDVEDPDnagktpLCTLMSKDSRP---HFTTVFENSVYKV 651
Dpy19L2 cd20179
C-mannosyltransferase Dpy-19-like protein 2 (Dpy19L2); Dpy19 proteins are ...
53-709 1.30e-64

C-mannosyltransferase Dpy-19-like protein 2 (Dpy19L2); Dpy19 proteins are C-mannosyltransferases that mediate C-mannosylation of tryptophan residues on target proteins. C-mannosylation is the attachment of alpha-mannose to the indole C2 carbon of the first tryptophan residue in the consensus amino acid sequence Trp-Xaa-Xaa-Trp/Cys through a C-C bond. This reaction takes place in the endoplasmic reticulum (ER) lumen. Dpy19 is a transmembrane domain family whose name is derived from the Caenorhabditis elegans Dumpy mutant. Dpy19L2 (also called protein Dpy-19 homolog 2) deletion is a major cause of globozoospermia.


Pssm-ID: 439132  Cd Length: 652  Bit Score: 226.47  E-value: 1.30e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758  53 IALCIGLLTSVYLATLHENDLWFSNIKEVEREISFRTECGLYYSYYKQMLQAPTLVQGFHGLIYDNKTESMKTINLLQRM 132
Cdd:cd20179   10 IAVFVAILHWLHLVTLFENDRHFSHLSSLEREMTFRTEMGLYYSYFKTIIEAPSFLEGLWMIMNDRLTEYPLIINAIKRF 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758 133 NIYQEVFLSILYRVL---------------------PIQKYL------EPVYFYIYTLFGLQAIYVTALYITSWLLSGTW 185
Cdd:cd20179   90 HLYPEVIIASWYCTFmgimnlfgletktcwnvtriePLNEVQsceglgDPACFYVGVIFILNGLMMGLFFMYGAYLSGTQ 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758 186 LSGLLAAFWYVTNRIDTTRVEFTIPLRENWALPFFAIQIAAITYFLRPNlqpLSERLTLLAIFISTFLFSLTWQFNQFMM 265
Cdd:cd20179  170 LGGLITVLCFFFNHGEATRVMWTPPLRESFSYPFLVLQMCILTLILRTS---SNDRRPFIALCLSNVAFMLPWQFAQFIL 246
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758 266 LMQALVLFTLDSLDMLPAVKATWLYGIQITSLLLVCILQFFNSMILGSLLISFNLSVFIArkLQKNLKtgsfLNRLGKLL 345
Cdd:cd20179  247 FTQIASLFPMYVVGYIEPSKFQKIIYMNMISVTLSFILMFGNSMYLSSYYSSSLLMTWAI--ILKRNE----IQKLGVSK 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758 346 LHLFMV-----LCLTLFLNNIIKKILNLKSDEHIFKFLKAKfgLGATRDFDANLYLCEEAFGLLPFNTFGRLSDTLLfya 420
Cdd:cd20179  321 LNFWLIqgsawWCGTIILKFLTSKILGVSDHIRLSDLIAAR--ILRYTDFDTLIYTCAPEFDFMEKATPLRYTKTLL--- 395
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758 421 yifvLSITVIVAFVVAFHNLSDSTNQQSVGKMEKGTVDLKPETAYNLIHTILFGFLALSTMRMKYLWTSHMCVFASFgLC 500
Cdd:cd20179  396 ----LPVVMVITCFIFKKTVRDISYVLATNIYLRKQLLEHSELAFHTLQLLVFTALAILIMRLKMFLTPHMCVMASL-IC 470
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758 501 SPEIWELLLKSVHLYNpkricimrysVPILILLYLCYKFWPGMMDELSELREFYDPDTVELMNWINSNTPRKAVFAGSMQ 580
Cdd:cd20179  471 SRQLFGWLFRRVRFEK----------VIFGILTVMSIQGYANLRNQWSIIGEFNNLPQEELLQWIKYSTTSDAVFAGAMP 540
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666758 581 LLAGVKLCTGRTLTNHPHYEDSSLRERTRAVYQIYAKRAPEEVHALLRSFGTDYVILEDSICYeRRHRRGCRLRDLLDIA 660
Cdd:cd20179  541 TMASIKLSTLHPIVNHPHYEDADLRARTKIVYSTYSRKSAKEVRDKLLELHVNYYVLEEAWCV-VRTKPGCSMLEIWDVE 619
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|....*....
gi 289666758 661 nghmmdgpgendpDLKPADHPRFCEEIKRNLPPyvaYFTRVFQNKTFHV 709
Cdd:cd20179  620 -------------DPSNAANPPLCSVLLEDARP---YFTTVFQNSVYRV 652
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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