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Conserved domains on  [gi|46409310|ref|NP_997219|]
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zinc finger protein 467 isoform 1 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
190-565 4.95e-14

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 74.73  E-value: 4.95e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46409310 190 CPDCGRSFTQRAHMLLHQRSHRGERPFPCS--ECDKRFSKKAHLTRHLRTHTGERPY-PCAECGKRFSQKIHLGSHQKTH 266
Cdd:COG5048  36 CPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDlNSKSLPLSNSKASSSSLSSSSS 115

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46409310 267 TGERPFPCTECEKRFRKKTHLIRHQRIHTGERPYQCAQCARSF--------THKQHLVRHQRVHQTAGPARPSPDSSASP 338
Cdd:COG5048 116 NSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSvntpqsnsLHPPLPANSLSKDPSSNLSLLISSNVSTS 195

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46409310 339 HSTAPSPTP-SFPGPKPFACSDCGLSFGwKKNLATHQCLHRSEGRPfgCDECALGATVDAPAAKPLASAPGGPGCGPGSD 417
Cdd:COG5048 196 IPSSSENSPlSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSL--LSQSPSSLSSSDSSSSASESPRSSLPTASSQS 272

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46409310 418 PVVPQRAPSGERSFF----CPDCGRGFSHGQHLARHPR--VHTGE--RPFACT--QCDRRFGSRPNLVAHSRAHSGARPF 487
Cdd:COG5048 273 SSPNESDSSSEKGFSlpikSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPA 352

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46409310 488 AC--AQCGRRFSRKSHLGRHQAVH-----TGSRPHACAV--CARSFSSKTNLVRHQAIHTGSRP--FSCPQCGKSFSRKT 556
Cdd:COG5048 353 KEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHY 432


                ....*....
gi 46409310 557 HLVRHQLIH 565
Cdd:COG5048 433 NLIPHKKIH 441
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
190-565 4.95e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 74.73  E-value: 4.95e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46409310 190 CPDCGRSFTQRAHMLLHQRSHRGERPFPCS--ECDKRFSKKAHLTRHLRTHTGERPY-PCAECGKRFSQKIHLGSHQKTH 266
Cdd:COG5048  36 CPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDlNSKSLPLSNSKASSSSLSSSSS 115

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46409310 267 TGERPFPCTECEKRFRKKTHLIRHQRIHTGERPYQCAQCARSF--------THKQHLVRHQRVHQTAGPARPSPDSSASP 338
Cdd:COG5048 116 NSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSvntpqsnsLHPPLPANSLSKDPSSNLSLLISSNVSTS 195

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46409310 339 HSTAPSPTP-SFPGPKPFACSDCGLSFGwKKNLATHQCLHRSEGRPfgCDECALGATVDAPAAKPLASAPGGPGCGPGSD 417
Cdd:COG5048 196 IPSSSENSPlSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSL--LSQSPSSLSSSDSSSSASESPRSSLPTASSQS 272

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46409310 418 PVVPQRAPSGERSFF----CPDCGRGFSHGQHLARHPR--VHTGE--RPFACT--QCDRRFGSRPNLVAHSRAHSGARPF 487
Cdd:COG5048 273 SSPNESDSSSEKGFSlpikSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPA 352

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46409310 488 AC--AQCGRRFSRKSHLGRHQAVH-----TGSRPHACAV--CARSFSSKTNLVRHQAIHTGSRP--FSCPQCGKSFSRKT 556
Cdd:COG5048 353 KEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHY 432


                ....*....
gi 46409310 557 HLVRHQLIH 565
Cdd:COG5048 433 NLIPHKKIH 441
zf-H2C2_2 pfam13465
Zinc-finger double domain;
230-255 2.76e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 2.76e-05
                          10        20
                  ....*....|....*....|....*.
gi 46409310   230 HLTRHLRTHTGERPYPCAECGKRFSQ 255
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
190-565 4.95e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 74.73  E-value: 4.95e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46409310 190 CPDCGRSFTQRAHMLLHQRSHRGERPFPCS--ECDKRFSKKAHLTRHLRTHTGERPY-PCAECGKRFSQKIHLGSHQKTH 266
Cdd:COG5048  36 CPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDlNSKSLPLSNSKASSSSLSSSSS 115

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46409310 267 TGERPFPCTECEKRFRKKTHLIRHQRIHTGERPYQCAQCARSF--------THKQHLVRHQRVHQTAGPARPSPDSSASP 338
Cdd:COG5048 116 NSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSvntpqsnsLHPPLPANSLSKDPSSNLSLLISSNVSTS 195

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46409310 339 HSTAPSPTP-SFPGPKPFACSDCGLSFGwKKNLATHQCLHRSEGRPfgCDECALGATVDAPAAKPLASAPGGPGCGPGSD 417
Cdd:COG5048 196 IPSSSENSPlSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSL--LSQSPSSLSSSDSSSSASESPRSSLPTASSQS 272

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46409310 418 PVVPQRAPSGERSFF----CPDCGRGFSHGQHLARHPR--VHTGE--RPFACT--QCDRRFGSRPNLVAHSRAHSGARPF 487
Cdd:COG5048 273 SSPNESDSSSEKGFSlpikSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPA 352

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46409310 488 AC--AQCGRRFSRKSHLGRHQAVH-----TGSRPHACAV--CARSFSSKTNLVRHQAIHTGSRP--FSCPQCGKSFSRKT 556
Cdd:COG5048 353 KEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHY 432


                ....*....
gi 46409310 557 HLVRHQLIH 565
Cdd:COG5048 433 NLIPHKKIH 441
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
242-565 5.11e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.18  E-value: 5.11e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46409310 242 RPYPCAECGKRFSQKIHLGSHQKTHTGERPFPCT--ECEKRFRKKTHLIRHQRIHTGERPYQCAQCarsfthkqhlvRHQ 319
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKS-----------LPL 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46409310 320 RVHQTAGPARPSPDSSASPHSTAPSPTPSFPGPKPFACSDCGLSFgwKKNLATHQCLHRSEGRPfgcdecalgatVDAPA 399
Cdd:COG5048 101 SNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISN--LRNNPLPGNNSSSVNTP-----------QSNSL 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46409310 400 AKPLASAPGGPGCGPGSDPVVPQRAPSGERSFFCPDCGRGFSHGQHLARHPRVHTGERPFACTQCDRRFGSRPNLVAHSR 479
Cdd:COG5048 168 HPPLPANSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSS 247

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46409310 480 AHSGARPFACAQCGR------RFSRKSHLGRHQAVHTG-SRPHACAVCARSFSSKTNLVRHQ--AIHTGS--RPFSCP-- 546
Cdd:COG5048 248 LSSSDSSSSASESPRsslptaSSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPys 327

                       330
                ....*....|....*....
gi 46409310 547 QCGKSFSRKTHLVRHQLIH 565
Cdd:COG5048 328 LCGKLFSRNDALKRHILLH 346
zf-H2C2_2 pfam13465
Zinc-finger double domain;
230-255 2.76e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 2.76e-05
                          10        20
                  ....*....|....*....|....*.
gi 46409310   230 HLTRHLRTHTGERPYPCAECGKRFSQ 255
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
529-554 1.34e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.34e-04
                          10        20
                  ....*....|....*....|....*.
gi 46409310   529 NLVRHQAIHTGSRPFSCPQCGKSFSR 554
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
286-311 7.52e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.52e-04
                          10        20
                  ....*....|....*....|....*.
gi 46409310   286 HLIRHQRIHTGERPYQCAQCARSFTH 311
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 216-238 9.22e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.89  E-value: 9.22e-04
                          10        20
                  ....*....|....*....|...
gi 46409310   216 FPCSECDKRFSKKAHLTRHLRTH 238
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 543-565 1.12e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.51  E-value: 1.12e-03
                          10        20
                  ....*....|....*....|...
gi 46409310   543 FSCPQCGKSFSRKTHLVRHQLIH 565
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
187-318 1.85e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 1.85e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46409310 187 PCACPDCGRSFTQRAHMLLHQRS--HRGE--RPFPCSE--CDKRFSKKAHLTRHLRTHTGERPYPC--AECGKRFSQKI- 257
Cdd:COG5048 289 PIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLn 368

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46409310 258 --HLGSHQK--------------------------------THTGERP--FPCTECEKRFRKKTHLIRHQRIHTGERPYQ 301
Cdd:COG5048 369 nePPQSLQQykdlkndkksetlsnscirnfkrdsnlslhiiTHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLL 448

                       170
                ....*....|....*..
gi 46409310 302 CAQCaRSFTHKQHLVRH 318
Cdd:COG5048 449 CSIL-KSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
261-281 3.66e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.66e-03
                          10        20
                  ....*....|....*....|.
gi 46409310   261 SHQKTHTGERPFPCTECEKRF 281
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 272-294 4.39e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 4.39e-03
                          10        20
                  ....*....|....*....|...
gi 46409310   272 FPCTECEKRFRKKTHLIRHQRIH 294
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
202-227 4.45e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.45e-03
                          10        20
                  ....*....|....*....|....*.
gi 46409310   202 HMLLHQRSHRGERPFPCSECDKRFSK 227
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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