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Conserved domains on  [gi|62461588|ref|NP_997485|]
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type 2 lactosamine alpha-2,3-sialyltransferase [Rattus norvegicus]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 10466376)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.-.-
Gene Ontology:  GO:0006486|GO:0008373
PubMed:  9334165

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 114-319 2.73e-139

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467712  Cd Length: 206  Bit Score: 392.57  E-value: 2.73e-139
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 114 PCKRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLGHEEEVGKRTTFRLFYPESVFSDPSHYDPNTTAVLVVFKPQD 193
Cdd:cd23984   1 SCKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESIFSDPSHYDPNTTVVLIPFKPHD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 194 LRWLMEILIGKKINTDGFWKKPALKLIYKQYQIRILDPYIIREAAFQLLRFPRVFPKDQKPKHPTTGIIALTLAFHICSE 273
Cdd:cd23984  81 LRWLLDLLMGKKVSAKGFWKKPALNLIYKPNQIRILNPFILRIAAYELLHFPKRFPKEKKPKHPTTGIIAITLALHICNE 160

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 62461588 274 VHLAGFKYNFYTPDSPLHYYGNATMSLMKKNAYHNLTAEQLFLKNL 319
Cdd:cd23984 161 VHIAGFKYDFSNLNSTLHYYGNETMSVMTKNEYHNISAEQKFLKDL 206
 
Name Accession Description Interval E-value
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 114-319 2.73e-139

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 392.57  E-value: 2.73e-139
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 114 PCKRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLGHEEEVGKRTTFRLFYPESVFSDPSHYDPNTTAVLVVFKPQD 193
Cdd:cd23984   1 SCKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESIFSDPSHYDPNTTVVLIPFKPHD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 194 LRWLMEILIGKKINTDGFWKKPALKLIYKQYQIRILDPYIIREAAFQLLRFPRVFPKDQKPKHPTTGIIALTLAFHICSE 273
Cdd:cd23984  81 LRWLLDLLMGKKVSAKGFWKKPALNLIYKPNQIRILNPFILRIAAYELLHFPKRFPKEKKPKHPTTGIIAITLALHICNE 160

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 62461588 274 VHLAGFKYNFYTPDSPLHYYGNATMSLMKKNAYHNLTAEQLFLKNL 319
Cdd:cd23984 161 VHIAGFKYDFSNLNSTLHYYGNETMSVMTKNEYHNISAEQKFLKDL 206
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 109-323 1.39e-73

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 227.49  E-value: 1.39e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588   109 EFDTVPCKRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLGHEEEVGKRTTFRLFYPESVFSD-------PSHYDPN 181
Cdd:pfam00777  37 PFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKTTLRTMNPESAIDSkygnlgfSHPRDPF 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588   182 TTAVLVVFKPQDLRWLMEILIGKKINTD----GFWKKPALKLiyKQYQIRILDPYIIREAAFQLLRFPRVfpkdqKPKHP 257
Cdd:pfam00777 117 VEFVLVPFKGRDLLWLPAFLTKGNVSRSlrvlYTLKEVKIPV--DPDKVLFLHPDFLRYVANFWLRSHGL-----KGRRP 189

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 62461588   258 TTGIIALTLAFHICSEVHLAGFKYNFYTPDSPLHYYGNATMSLMKKNAYHNLTAEQLFLKNLIKKK 323
Cdd:pfam00777 190 STGLLMLSLALHLCDEVSLYGFGPFLDSRGNSHHYYDNVLMKKGGFYGVHDMPFEFKLLQKLHKEG 255
 
Name Accession Description Interval E-value
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 114-319 2.73e-139

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 392.57  E-value: 2.73e-139
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 114 PCKRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLGHEEEVGKRTTFRLFYPESVFSDPSHYDPNTTAVLVVFKPQD 193
Cdd:cd23984   1 SCKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESIFSDPSHYDPNTTVVLIPFKPHD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 194 LRWLMEILIGKKINTDGFWKKPALKLIYKQYQIRILDPYIIREAAFQLLRFPRVFPKDQKPKHPTTGIIALTLAFHICSE 273
Cdd:cd23984  81 LRWLLDLLMGKKVSAKGFWKKPALNLIYKPNQIRILNPFILRIAAYELLHFPKRFPKEKKPKHPTTGIIAITLALHICNE 160

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 62461588 274 VHLAGFKYNFYTPDSPLHYYGNATMSLMKKNAYHNLTAEQLFLKNL 319
Cdd:cd23984 161 VHIAGFKYDFSNLNSTLHYYGNETMSVMTKNEYHNISAEQKFLKDL 206
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 114-319 1.23e-110

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 320.01  E-value: 1.23e-110
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 114 PCKRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLGHEEEVGKRTTFRLFYPESVFSDPSHYDPNTTAVLVVFKPQD 193
Cdd:cd23967   1 SCRRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFRMFYPESAFRDPEEYDSDWLLVLVPFKSMD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 194 LRWLMEILIGKKINT-DGFWKKPALKLIYKQYQIRILDPYIIREAAFQLLRFPrvFPKDQKPKHPTTGIIALTLAFHICS 272
Cdd:cd23967  81 LLWLQAVIKGKKPNGkGGFWKKIATSVPKPPKKIRILNPYILQEAAFDLIGLP--MNGKQGKNVPTTGIIAIVMALHYCD 158

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 62461588 273 EVHLAGFKYNFYTPDSPLHYYGNATMSLMKKNAYHNLTAEQLFLKNL 319
Cdd:cd23967 159 EVDIAGFGYDPSDPNAPLHYYDSLTMKAIKRSWTHNVTKEKKYLKKL 205
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 114-319 6.75e-83

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 249.58  E-value: 6.75e-83
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 114 PCKRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLGHEEEVGKRTTFRLFYPESVFSDPS-HYDPNTTAVLVVFKPQ 192
Cdd:cd23982   1 RCRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFYPESAQFDPGiENDPDTLLVLVPFKPL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 193 DLRWLMEILIGKKINTDGFWKKPALKLIYKQYQIRILDPYIIREAAFQLLRFPRvfpKDQKPKHPTTGIIALTLAFHICS 272
Cdd:cd23982  81 DFYWLYEILSNEKRVRKGFWKQPPRIWDANPKQIRILNPYYTYVAATKLLQVPG---QRKKKQKPTTGLLAITLALHLCD 157

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 62461588 273 EVHLAGFKY-NFYTPDSPLHYYGNATMSLMkKNAYHNLTAEQLFLKNL 319
Cdd:cd23982 158 EVHIAGFGYpDNGNSNQPIHYYNQITLKSM-ANSGHNLNAEAQAIQRL 204
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 114-319 7.75e-74

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 226.93  E-value: 7.75e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 114 PCKRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLGHEEEVGKRTTFRLFYPESVFSDPSHYDPNTTAVLVVFKPQD 193
Cdd:cd23983   1 TCRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEGAPKSEQEYDPTSLFVAVLFKSVD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 194 LRWLMEILIGKKI---NTDGFWKKPALKLIYKQYQIRILDPYIIREAAFQLLRFP----RVFPKDQkpKHPTTGIIALTL 266
Cdd:cd23983  81 FAWLKAMVKKEPLsfwSRLFFWKEVADSIPLKPSQFRILNPLIIKETALDILQYPepqsRLWGWDK--NVPTLGVTAVVL 158

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 62461588 267 AFHICSEVHLAGFKYNFYTPDSPLHYYGNATMSLMKKNAYHNLTAEQLFLKNL 319
Cdd:cd23983 159 ATHLCDEVSLAGFGYDLSQPHAPLHYYDSVCMAAMNTQTMHNVTKETKFLKKL 211
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 109-323 1.39e-73

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 227.49  E-value: 1.39e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588   109 EFDTVPCKRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLGHEEEVGKRTTFRLFYPESVFSD-------PSHYDPN 181
Cdd:pfam00777  37 PFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKTTLRTMNPESAIDSkygnlgfSHPRDPF 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588   182 TTAVLVVFKPQDLRWLMEILIGKKINTD----GFWKKPALKLiyKQYQIRILDPYIIREAAFQLLRFPRVfpkdqKPKHP 257
Cdd:pfam00777 117 VEFVLVPFKGRDLLWLPAFLTKGNVSRSlrvlYTLKEVKIPV--DPDKVLFLHPDFLRYVANFWLRSHGL-----KGRRP 189

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 62461588   258 TTGIIALTLAFHICSEVHLAGFKYNFYTPDSPLHYYGNATMSLMKKNAYHNLTAEQLFLKNLIKKK 323
Cdd:pfam00777 190 STGLLMLSLALHLCDEVSLYGFGPFLDSRGNSHHYYDNVLMKKGGFYGVHDMPFEFKLLQKLHKEG 255
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 115-319 2.97e-70

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 217.48  E-value: 2.97e-70
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 115 CKRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLGHEEEVGKRTTFRLFYPESVFSDPSHYDPNTTAVLVVFKPQDL 194
Cdd:cd23981   2 CRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKPEQYEKDSLFVLAGFKWQDF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 195 RWLMEILIGKKIN-TDGFWKKPALKLIYKQYQIRILDPYIIREAAFQLLRFPRVFPKDQKPKHPTTGIIALTLAFHICSE 273
Cdd:cd23981  82 KWLKYIVYKEKVSaSDGFWKSVATRVPREPHEIRILNPYFIQEAAFSFIGLPFNNGLMGRGNIPTLGSVAITMALHNCDE 161

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 62461588 274 VHLAGFKYNFYTPDSPLHYYGNATMSLMKKNAYHNLTAEQLFLKNL 319
Cdd:cd23981 162 VAVAGFGYDMNTPNAPLHYYETIKMSAIKESWTHNIQREKEFLRKL 207
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 81-312 1.22e-37

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 135.85  E-value: 1.22e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588  81 FLLPYGVKTFE-SYFRSALSKLQSCDLFGEF----DTVPCKRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLGHEE 155
Cdd:cd23964  43 YKLPFGWGGLNrEVVERLLRNLNLTSSRYMFvlrgGRPRCIRCAVVGNGGILNGSGKGKEIDAHDYVFRVNHALTKGFEK 122

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 156 EVGKRTTFRLFYPESVF-SDPSHY--DPNTTAVLVVFKPQDLRWLMEILIGKKINT---DGFWKKPALKLIYKQYQIRIL 229
Cdd:cd23964 123 DVGTKTSFYTFFPESLHnSLLKHVpqDKDTKYLFIPFKIRDYDYLDAVLSGKPVPDgcdKGKRPPPLFGPKLNATNVRLL 202

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 230 DPYIIREAAFQLLRFPRVFpkdqkpkHPTTGIIALTLAFHICSEVHLAGFKYNfytPDSPLHYYGNATMSLMKKNAYHNL 309
Cdd:cd23964 203 HPDFIRYLFNRWLNSSTSY-------RPTTGALMLLTALHTCDQVSVYGFGYD---PRFSLHYYDKTFVKFTVFYANHDF 272


                ...
gi 62461588 310 TAE 312
Cdd:cd23964 273 TNE 275
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 105-323 1.69e-37

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 135.10  E-value: 1.69e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 105 DLFGEFDTVPCKRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLGHEEEVGKRTTFRLFYPESVfsdpSHYDPNTTA 184
Cdd:cd23966  67 NPYRTRDPNRCRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFMYPESA----VDLDPGVHL 142

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 185 VLVVFKPQDLRWLMEILIGKKINTDGFWKKPALKLIYKqyQIRILDPYIIREAAFQLLrfprvfpkDQKPKHPTTGIIAL 264
Cdd:cd23966 143 VLVPFKVLDLQWLISALTTGEITRTYTPVKRFIKADKD--KVLVINPAFIKYVHDNWT--------EHHGRYPSTGFLAL 212

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 62461588 265 TLAFHICSEVHLAGF----KYNFYtpdsplHYY-GNATMSLMKKNAYHNLTAEQLFLKNLIKKK 323
Cdd:cd23966 213 IFALHICDEVSVFGFgadsKGNWH------HYWeKNRSAGAFRKTGVHDADFESDIIKKLAKEG 270
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 118-319 3.00e-37

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 132.10  E-value: 3.00e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 118 CVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLGHEEEVGKRTTFRL-------FYPESVFSDPSHYDPNTTAVLVVFK 190
Cdd:cd19952   1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVlnskwagFYLRGPRCGCHPLPLEEEVVLILSR 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 191 PQDlrwlmeiligkkinTDGFWKKPALKLIYKQyqirildPYIIREAAFQLL-----RFPRVFPK-DQKPKHPTTGIIAL 264
Cdd:cd19952  81 AAA--------------ADFKRLKRRKKRHDNA-------VLLLTDPAPDLLsyvrkRLEKLGLKsFFGGNAPSSGLLAV 139

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 62461588 265 TLAFHICSEVHLAGF-KYNFYTPDSPLHYYGNATMSLMkkNAYHNLTAEQLFLKNL 319
Cdd:cd19952 140 LLALQLCDSVDLYGFgVDSGHAPKVPYHYYDLVEAEEG--TAVHSFDLEAELLRAL 193
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 105-319 9.30e-28

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 109.20  E-value: 9.30e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 105 DLFGEFDTVPCKRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLGHEEEVGKRTTFRLFYPESVfsdpSHYDPNTTA 184
Cdd:cd23980  71 DPLLEKRLVSCRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTTHHFVYPESF----RELAQNVSM 146

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 185 VLVVFKPQDLRWLMEILIGKKINTDgFWKKPAlKLIYKQYQIRILDPYIIREAAFQLLRfprvfpkdQKPKHPTTGIIAL 264
Cdd:cd23980 147 ILVPFKTLDLEWVISATTTGTISHT-YVPVPR-KIKVKKEKILIYHPAFIKYVFDRWLQ--------GHGRYPSTGILSV 216

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 265 TLAFHICSEVHLAGF----KYNFYtpdsplHYY-GNATMSLMKKNAYHNLTAEQLFLKNL 319
Cdd:cd23980 217 IFSLHVCDEVDLYGFgadsKGNWH------HYWeNNPSAGAFRKTGVHDGDFESNVTTIL 270
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 116-319 7.16e-26

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 103.89  E-value: 7.16e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 116 KRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLGHEEEVGKRTTFRLFYPEsVFSDPSHYDPNTT----AVLVVFKP 191
Cdd:cd23968  46 NTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKGFEKDVGSKTTLRLINSQ-ILSKPEFNFLTDPlyrnVTLLVWDP 124

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 192 QdlrwlmeiligkKINTDG--FWKKPALKLI--YKQYQIR-------ILDPYIIREAAFQLLRFprvFPKDQKPKHPTTG 260
Cdd:cd23968 125 S------------SYNVNLekWYKKPDFDFFpnYIKYRRRhpeepfyLIDPRFLWRLWDILQEY---TPEKIKPNPPSSG 189

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 62461588 261 IIALTLAFHICSEVHLagfkYNFYTP--DSPL-HYYGNATMSLMKKNAYHNLTAEQLFLKNL 319
Cdd:cd23968 190 FIGIVLMLHLCDWVDV----YEYVPSvrQTDRcHYYDVEKDLACTLGAWHPLAAEKLLVRHL 247
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 115-294 2.50e-25

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 101.55  E-value: 2.50e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 115 CKRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLGHEEEVGKRTTFRLF-YP--ESVFSDPSHYDPNTTA-VLVVFk 190
Cdd:cd23965   1 CDTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRVVsHSslPRLLRNAILLLAGTRApTVVVF- 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 191 pqdlrWLMEIligkKINTDGFWKKPALKLIYKQYqiRILDPYIIREAafQLLRFPRVFPKDQ-KPKHPT-----TGIIAL 264
Cdd:cd23965  80 -----WGPET----KMNKDGAGKYNLLRSLSKKY--PDVEFYSLTPE--KMDYADELFEKETgKSRIKSgtwlsTGWFTM 146

                       170       180       190
                ....*....|....*....|....*....|....*
gi 62461588 265 TLAFHICSEVHLAGFKYNFY-----TPDSPLHYYG 294
Cdd:cd23965 147 LLALDVCDEIKVYGMVPENYcrehpNSKVPYHYYE 181
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 116-329 5.26e-25

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 101.57  E-value: 5.26e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 116 KRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLGHEEEVGKRTTFRLFYPESVfsdpSHYDPNTTavlvvfKPQDLR 195
Cdd:cd23963  64 KTCAVVGNSGILLGSGCGKEIDSHDFVIRCNLPPIKGFEKDVGRKTNLTTLNPSIL----KRRYNSLK------KNRDRD 133

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 196 WLMEILigKKINTDGFWKKPALKLIYKQYQIRILDPYIIREAAFQLL----RFPRVFPK----DQKPKHPTTGIIALTLA 267
Cdd:cd23963 134 KFLNRL--KEYNGSILWYPKFSFKSSTNLLLKAARALKKNGLNLTVVysnpEHFLAVQKfwkrRGLEKRPSTGLYLVSLA 211

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 62461588 268 FHICSEVHLAGFkYNFYTpDS-----PLHYYGNATMSLMKKNayHNLTAEQLFLKNLiKKKMVINLT 329
Cdd:cd23963 212 LTFCDEIHLYGF-WPFPT-DPngrpvPYHYYDDLSPSTKNKV--HNMPEEFKLLREL-HKKGVLKLH 273
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 107-279 3.48e-24

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 99.56  E-value: 3.48e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 107 FGEFDTVPCKRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLGHEEEVGKRTTFRLFYPESVFSDPshydPNTTAVL 186
Cdd:cd23979  72 YRSWDPSRCRRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTTHHFMYPESAKNLP----ANVSFVL 147

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 187 VVFKPQDLRWLMEILIGKKINTDGFWKKPALKLiyKQYQIRILDPyiireaAFqllrFPRVFPK--DQKPKHPTTGIIAL 264
Cdd:cd23979 148 VPFKTLDLLWITSALSTGQIRFTYAPVKQFLRV--DKDKVQIYNP------AF----FKYIHDRwtEHHGRYPSTGMLVL 215

                       170
                ....*....|....*
gi 62461588 265 TLAFHICSEVHLAGF 279
Cdd:cd23979 216 FFALHVCDEVNVYGF 230
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 115-303 6.75e-21

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 90.97  E-value: 6.75e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 115 CKRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLGHEEEVGKRTTFRLFYPESVFSDPSHY----------DPNTTA 184
Cdd:cd23973  83 CIRCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYEEDVGTRTSFYVHTAHSITSSLMILqkrgfknipqDKDIKY 162

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 185 VLVVFKPQDLRWLMEILIGKKINTDGFWKKPALKLIYKQYQIR---ILDPYIIREAAFQLLRFPRVFPKDQKPKHPTTGI 261
Cdd:cd23973 163 ILFPEGPRDYQWLEALLKNKTIPSGAYYGRRPRSYFSGDFTEDkylVLHPDFLRYVKNRFLRSKTLKGKYWAIYRPTTGA 242

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 62461588 262 IALTLAFHICSEVHLAGF------KYNFYTPD---SPLHYYGNATMSLMKK 303
Cdd:cd23973 243 FLLLTALHLCDTVSAYGFitedyrKYPDHYYDkkkTKLVFYINHDFRLEKK 293
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 114-322 7.63e-19

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 84.76  E-value: 7.63e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 114 PCKRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLGHEEEVGKRTTFRLF------YPESVFSDPSHYdpnTTAVLV 187
Cdd:cd23985  44 PLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTAGFQQDVGTKTTIRLInsqlvtTEKHKFLKDSLY---NEGILI 120

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 188 VFKPQDLrwlmeiligkKINTDGFWKKPALKLI--YKQYqiRILDP----YIIR-EAAFQLL-RFPRVFPKDQKPKHPTT 259
Cdd:cd23985 121 VWDPAPY----------HSDIPEWYKNPDYNFFenYKTY--RRLNPnqpfYILHpQMQWELWdIIQENSPEEIQPNPPSS 188

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 62461588 260 GIIALTLAFHICSEVHLagfkYNFYTPDSP---LHYYGNATMSLMKKNAYHNLtaeqLFLKNLIKK 322
Cdd:cd23985 189 GMLGIILMMTLCDQVDV----YEFLPSKRKtdvCHYYQKFFDRACTMGAYHPL----LYEKNLVKH 246
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 114-295 1.02e-16

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 79.41  E-value: 1.02e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 114 PCKRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLGHEEEVGKRTTFRLFYPESVFSDPSHYD-------PNTTAVL 186
Cdd:cd23974  83 PCIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTSFYTFSTNTLMNSLRAYAgvgfngpPQSKETR 162

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 187 VVFKPQDLR--WLMEILIGKKINTDG--FWKKPALKL--IYKQYQIRILDPYIIREAAFQLLRFPRVFPKDQKPKHPTTG 260
Cdd:cd23974 163 YIFLPDHDRdyLLVKAALTHTPIDRGrdKSKRPSKYFgkDVTAEKFKIYHPDFIRYLRNRFLWSPILNTKQRDIYRPSTG 242

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 62461588 261 IIALTLAFHICSEVHlagfKYNFYTPDSPL---HYYGN 295
Cdd:cd23974 243 AVMLLAALHTCDQVS----AYGFMTPDYGKysdHYYDK 276
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 116-321 5.26e-16

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 76.80  E-value: 5.26e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 116 KRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLGHEEEVGKRTTFRLFYPEsVFSDPSHYDPNTT----AVLVVFKP 191
Cdd:cd23986  50 RSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRIINSQ-ILTNPNHHFIDSSlykdVILVAWDP 128

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 192 QDLrwlmeiligkKINTDGFWKKPALKLI--YKQYQIRILD-PYIIREAAF--QLLRFPRVFPKDQ-KPKHPTTGIIALT 265
Cdd:cd23986 129 APY----------SANLHKWYKKPDYNLFtpYVQYRKRNPNqPFYILHPKFiwQLWDIIQENTQEKiQPNPPSSGFIGIL 198

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 62461588 266 LAFHICSEVHLAGFKYNFYTPDSpLHY---YGNATMSLmkkNAYHNLTAEQLFLKNLIK 321
Cdd:cd23986 199 IMMSMCREVHVYEYIPSVRQTDL-CHYherYYDAACTL---GAYHPLLYEKLLIQRMNK 253
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 116-329 5.32e-16

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 77.05  E-value: 5.32e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 116 KRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLGHEEEVGKRTTFRLFYPesvfSDPSHYDPNttavlvVFKPQDLR 195
Cdd:cd23970  69 NTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNLTTFNP----SILEKYYNN------LLTIQDRN 138

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 196 WLMEILigKKINTDGFWkKPALKLIYKQYQIRILDPYIIreaafQLLRFPRV---FP-------------KDQKPKHPTT 259
Cdd:cd23970 139 NFFLSL--KKLDGAILW-IPAFFFHTSATVTRTLVDFFV-----EHRGQLKVqlaWPgnimqhvnrywktKHLSPKRLST 210

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 62461588 260 GIIALTLAFHICSEVHLAGFkYNFYT----PDSPLHYYGN-ATMSLMKKNAYHNLTAEQLFLKNLiKKKMVINLT 329
Cdd:cd23970 211 GILMYTLASAICEEIHLYGF-WPFGFdptgTPLPYHYYDKkGTKFTTKWQESHQLPAEFVLLYKM-HGAGVLKLT 283
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 115-293 5.18e-14

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 70.27  E-value: 5.18e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 115 CKRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLGHEEEVGKRTTFRLFYPESVFSdpshydpnttavlVVFKPQDL 194
Cdd:cd23978   1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRVVAHSSVYR-------------VLRRPQEF 67

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 195 --RWLMEILIgkkintdgFW------KKPALKLIYKQYQ-----IRILDPYII---REAAFQLLrFPRVFPKDQKPKHP- 257
Cdd:cd23978  68 lnRTPETTLI--------FWgppnkmQKDGKSNLFRIIQrasmtFPNMSAFVVsprRMRQFDDL-FRGETGRDRKKSHSw 138

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 62461588 258 -TTGIIALTLAFHICSEVHLAGF-KYNFYTPDS-----PLHYY 293
Cdd:cd23978 139 lSTGWFTMVIAVELCDNVHVYGMvPPNYCSKRPtpkkmPYHYY 181
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 115-293 2.15e-13

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 68.42  E-value: 2.15e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 115 CKRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLGHEEEVGKRTTFRLFYPESV---FSDPSHY--DPNTTaVLVVF 189
Cdd:cd23975   1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTSVpllLKNPDYFfkETNET-IYVIW 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 190 KP-----QDLRWLMEILIGKKINtdgfwkkpalklIYKQYQIrildpYIIREAafQLLRFPRVFPKD------QKPKHPT 258
Cdd:cd23975  80 GPfrnmrKDGKGIVYNMLKKAVE------------SYPQAKI-----YVTTEK--RMSYCDTVFKKEtgkdrvQSGSYLS 140

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 62461588 259 TGIIALTLAFHICSEVHLAGFKYNFYTPDS-----PLHYY 293
Cdd:cd23975 141 TGWFTLILAMDACYGIHVYGMINDTYCKTEgyrkvPYHYY 180
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 116-323 8.70e-13

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 67.44  E-value: 8.70e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 116 KRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLGHEEEVGKRTTFRLFYPeSVFSDPSHYDPNTTavlvvfkpqDLR 195
Cdd:cd23969  65 RTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVGTKSNLTTMNP-SVIPHAYGDLVNAT---------DKE 134

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 196 WLMEILigKKINTDGFWkKPALKLIYKQYQIRILDPYIIREAAFQLLRFP--------RVFPKDQK--PKHPTTGIIALT 265
Cdd:cd23969 135 KFVERL--RQLGDSILW-IPAFVSKGGEEHVQWTNEIILKHKLNVKTAYPplrlnhaiRGYWLTTKfrIKRPSTGLLMYT 211

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 62461588 266 LAFHICSEVHLAGFkYNFyTPD---SPL--HYYGNATMSLmkKNAYHNLTAEQLFLKNLIKKK 323
Cdd:cd23969 212 LATRFCDEIHLYGF-YPF-SEDgngRAVkyHYYDNRKYLT--TARPHKMPEEFRALRSLHQRG 270
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 115-326 3.00e-12

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 65.27  E-value: 3.00e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 115 CKRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLGHEEEVGKRTTFRLFYPESV----FSDPSHYDPNTTAVLVVFK 190
Cdd:cd23977   1 CRRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRVVSHTSVplllRNQGYFFQQSRDTKYVIWG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 191 PqdLRWLMEILIGKKINTdgfwkKPALKLIYKQYQIrildpYIIREAAFQLLrfPRVFpKDQKPKHP-------TTGIIA 263
Cdd:cd23977  81 P--ERNMDRDGGGKTYRA-----LLTLAKMYPHLQV-----YTLTEEKMAYC--DGVF-QNETGKNRmksgsflSTGWFT 145

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 62461588 264 LTLAFHICSEVHLAGFKYNFYT-----PDSPLHYY-----GNATMSLMKKNAY---HNLTAEQLFLKNLIKKKMVI 326
Cdd:cd23977 146 MILALELCEEILVYGMVSDSYCrnknhSSVPYHYYekgrlDECRMYLVHERAPrggHRFITEKAIFSRWAKRKKIR 221
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 49-300 3.23e-12

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 66.00  E-value: 3.23e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588  49 PAFASLLRFPqfYPFLCKADFVKVAATYGTNNFLLPYGVKTF-ESYFRSALSKL---QSCDLFGEFDTVP-CKRCVVVGN 123
Cdd:cd23972  13 PHFRGLFNFD--IPVLLWGQHFTPALWDRLSQRKVPYGWKGLsHQVVASTLSLLndsANAKLFFPRDTPGkCIRCAVVGN 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 124 GGVLKNKTLGAKIDSYDVIIRMNNGPVLGHEEEVGKRTTFRLF-----------YPESVFsdpsHYDPNTTAVLVVFKPQ 192
Cdd:cd23972  91 GGILNGSRQGRAIDAHDYVFRLNGAVIKGFEEDVGTKTSFYGFtvntmknslisYWNLGF----TRTPQGQDLQYIFIPS 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 193 DLR---WLMEILIGKKI-----NTDGFWKKPALKLIYKQYqiRILDPYIIREAAFQLLRFPRVFPKDQKPKHPTTGIIAL 264
Cdd:cd23972 167 DIRdyvMLRSAILGVPVpegldKGDRPHKYFGPEASAKKF--KLLHPDFISYLTDRFLKSKLLNTHYGHLYMPSTGALML 244

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 62461588 265 TLAFHICSEVHLAGF---KYN-----FYTPDS-PLHYYGNATMSL 300
Cdd:cd23972 245 LTALHTCDQVSAYGFitsNYWkfsdhYYERKKkPLVFYANHDMLL 289
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 116-314 5.71e-12

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 64.98  E-value: 5.71e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 116 KRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLGHEEEVGKRTTFRLFYPE----------------------SVFS 173
Cdd:cd23988  65 KTCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVEFAADVGTKSDFITMNPSvvqrafggfrnesdrekfvhrlSMLN 144

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 174 DPSHYDPnttAVLVVFKPQDLRWLMEILIGKKINTDGFWkkPALKLIYKQYQIRILDPYIIreaafqllrfprvfpkdqk 253
Cdd:cd23988 145 DSVLWIP---AFMVKGGEKHVEWVNALILKNKLKVRTAY--PSLRLIHAVRGYWLTNKVNI------------------- 200

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 62461588 254 pKHPTTGIIALTLAFHICSEVHLAGF------------KYNFYTpDSPLHYYGNAT---MSLMKK--NAYHNLTAEQL 314
Cdd:cd23988 201 -KRPSTGLLMYTLATRFCDEIHLYGFwpfpkdangnpvKYHYYD-DLKYRYFSNAGphrMPLEFKtlNVLHNRGALKL 276
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 116-319 1.30e-11

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 64.19  E-value: 1.30e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 116 KRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLGHEEEVGKRTTFRLFYPESV---FSDPShydpNTT--------- 183
Cdd:cd23987  65 KTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGTKTDLVTMNPSVVqraFEDLV----NETwkekflqrl 140

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 184 -----------AVLVVFKPQDLRWLMEILIGKKINTDGFWkkPALKLIYKQYQIRILDPYIIreaafqllrfprvfpkdq 252
Cdd:cd23987 141 qslngsilwipAFMAKGGEERVEWVNDLILKHHINVRTAY--PSLRLLHAVRGYWLTNKVHI------------------ 200

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 253 kpKHPTTGIIALTLAFHICSEVHLAGFKYNFYTPD-SPL--HYYGNATMSLMKKNAYHNLTAEQLFLKNL 319
Cdd:cd23987 201 --KRPTTGLLMYTLATRFCNRIHLYGFWPFPRDQNqNPVkyHYYDSLKYGYTSQASPHTMPLEFKALKNL 268
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 110-322 8.88e-11

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 61.50  E-value: 8.88e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 110 FDTVPCKRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPvLGHEEEVGKRTTFrlfypesVFSDPShydpnttavlvvf 189
Cdd:cd23971  59 FSNKPLKTCAVVGNGGILKNSSCGREIDSADFVIRCNLPP-LNDSKDVGSKTNL-------VTANPS------------- 117

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 190 kpqdlrwlmeILIGKKINTDGfWKKPALKLIyKQYQ------------------IRILdpYIIRE-AAFQLLRF--PR-- 246
Cdd:cd23971 118 ----------ILREKFHNLKK-RRRPFVERM-KVYGnallllpafsytsntepsLRAL--YTLEDfGSPQKVLFfnPEyl 183

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 247 ----VFPKDQ--KPKHPTTGIIALTLAFHICSEVHLAGF-KYNFYTPDSPL--HYYGNatmsLMKKNAYHNLTAEQLFLK 317
Cdd:cd23971 184 rnlsRYWKSKglKARRLSTGLMLVSAALELCENVHLYGFwPFSTDLDGNPIshHYYDN----VLPKKGVHAMPEEFLRYL 259


                ....*
gi 62461588 318 NLIKK 322
Cdd:cd23971 260 KLHSQ 264
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 113-321 1.59e-08

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 54.84  E-value: 1.59e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 113 VPCKRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVL-GHEEEVGKRTTFrlfypesVFSDPSHYDPnttavlvvfKP 191
Cdd:cd23989  61 LPLKKCSVVGNGGILKNSGCGQQIDRADFVMRCNLPPLSrEYTDDVGTKTQL-------VTANPSIIDK---------RF 124

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 192 QDLRW-------LMEILIGKKINTDGFWKKPALKLIYKQYQIrILDPYIIREAAF---QLLRFPRVF--PKDQKPKHPTT 259
Cdd:cd23989 125 QNLLWsrksfveSMKVYGRSYIYMPAFSMKTGTDPSLRVYYT-LADVGANQTVLFanpNFLRNVGKFwkSKGVHAKRLST 203

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 62461588 260 GIIALTLAFHICSEVHLAGF-KYNFYTPDSPL--HYYGNatmsLMKKNAYHNLTAEQLFLKNLIK 321
Cdd:cd23989 204 GLFLVSAALGLCEEVTIYGFwPFSVDLDERTIshHYYDN----VLPDSGFHAMPEEFLQLWHLHK 264
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 116-295 3.40e-08

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 53.69  E-value: 3.40e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 116 KRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLG-HEEEVGKRTTFRLFYPESV---FSDPSHYDPNTTAVLVVFKP 191
Cdd:cd23990  65 KKCAVVGNGGILKNSKCGREIDSADFVFRCNLPPISEkYVRDVGVKTDVVTINPSIIterFHKLEKWRRPFYEVLQVYEN 144

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 192 QDLrwLMEILIGKKiNTD-GFWKKPALKLIYKQYQIRILDP-YIIREAAFQLLRFPRVfpkdqkpKHPTTGIIALTLAFH 269
Cdd:cd23990 145 ASV--VLPAFYNTR-NTDvSIRVKYVLDDFESQQAVYYFHPqYLLNVSRFWLRQGVRA-------KRISSGLMLVTAALE 214

                       170       180       190
                ....*....|....*....|....*....|
gi 62461588 270 ICSEVHLAGFkYNFYTPDSPL----HYYGN 295
Cdd:cd23990 215 LCEEVHLYGF-WAFPMNPSGIfithHYYDN 243
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 110-324 4.13e-08

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 53.60  E-value: 4.13e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 110 FDTVPCKRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLGHE-EEVGKRTTFrlfypesVFSDPShydpnttavlvv 188
Cdd:cd23991  59 FRGYPYKQCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGNIsKDVGSKTNL-------VTANPS------------ 119

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 189 fkpqdlrwlmeiLIGKKINTDGFWKKPALKLIYKQYQIRILDPYIIREA----AFQLLRFPRVFPKDQKPK--HPT---- 258
Cdd:cd23991 120 ------------IISIKYAKLNERRKPFLETVSVYGDAFLLLPAFSYRSntalSFKVYYTLEDFKAKQKVIffHPIylkh 187

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 259 ----------------TGIIALTLAFHICSEVHLAGF-KYNFYTPDSPL--HYYGNatmsLMKKNAYHNLTAE-----QL 314
Cdd:cd23991 188 laqfwrskgvqvyrlsTGLMITSAALELCEEVKLYGFwPFSKNTEGKPIshHYYDN----QLPKPGFHSMPKEfyqllQL 263

                       250
                ....*....|
gi 62461588 315 FLKNLIKKKM 324
Cdd:cd23991 264 HSKGILKLQF 273
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 115-293 7.61e-08

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 52.56  E-value: 7.61e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 115 CKRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLGHEEEVGKRTTFRLFYPESVfsdpshydpnttavlvvfkPQDL 194
Cdd:cd23976  15 CKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSI-------------------QRIL 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62461588 195 RWLMEILIGKKINTDGFW------KKPALKLIYKQYQI--RI---LDPYIIREAafQLLRFPRVFP----KDQKPKHP-- 257
Cdd:cd23976  76 RNRNELLNVSQGTVFIFWgpsnymRRDGKGLVYNNLQLmnQIlpkLKVYTITRH--KMLQFDELFKretgKDRKISNTwl 153

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 62461588 258 TTGIIALTLAFHICSEVHLAG-----FKYNFYTPDSPLHYY 293
Cdd:cd23976 154 STGWFTMIIALELCDRINVYGmvppdFCRDPNHPSVPYHYY 194
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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