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Conserved domains on  [gi|47086659|ref|NP_997855|]
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phospholipase A-2-activating protein [Danio rerio]

Protein Classification

WD repeat PLAP family protein( domain architecture ID 10078051)

WD repeat PLAP family protein containing WD40, PFU, and PUL domains, similar to vertebrate phospholipase A-2-activating protein (PLAP or PLAA), a ubiquitin-binding protein involved in protein ubiquitination, sorting and degradation

CATH:  2.130.10.10
Gene Ontology:  GO:0005515|GO:0043130
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PUL pfam08324
PUL domain; The PUL (PLAP, Ufd3p and Lub1p) domain is a novel alpha-helical Ub-associated ...
 536-791 6.17e-71

PUL domain; The PUL (PLAP, Ufd3p and Lub1p) domain is a novel alpha-helical Ub-associated domain. It directly binds to Cdc48, a chaperone-like AAA ATPase that collects ubiquitylated substrates.


:

Pssm-ID: 462428  Cd Length: 261  Bit Score: 233.38  E-value: 6.17e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086659   536 PNTDGVMFEQSNTAQILGKLRELNTSAPADHKLSDAALDCLEKLLNLvteLPNLEQPTAEQITVLWRAC-HWPEDIVFPV 614
Cdd:pfam08324   1 PQKTYLSFKKANLDKILKKLGEFNGGEPKVLALSPEELATLEALLSF---LESSSSASEADIELLLKILtSWPPEDRFPA 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086659   615 LDILRLAVRHPEVNAHLCGGtEGASLCNHLLGLMSPEGKAANQMLALRTLCNCFTASHGRALLLGQRDAVLSRAGDLRTV 694
Cdd:pfam08324  78 LDLLRLLALDPRVAAYFAEE-EGGKTISTLLSLLISSGLYALRMLALRLLCNLFSSPLGRQLLLSHFDSILSTLASLLSS 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086659   695 C----NKNIHVALATLVLNYAGRLY--GQPAEIEAKAQCLSVASTALEVVQ-DKEAVFRLLVALGTTV--SGDSTAKDLA 765
Cdd:pfam08324 157 SlldsNKNLRIALATLLLNYAVLLHkeKSPLSEEDQVELLAALLEALSTEEeDSEALYRLLVALGTLVyaPDGEVLADLA 236

                         250       260
                  ....*....|....*....|....*.
gi 47086659   766 RSLGVNSQISKYARVSEPaKVGECCR 791
Cdd:pfam08324 237 QVLDAASWVKKAKKKKEP-RIKEVGS 261
PFU pfam09070
PFU (PLAA family ubiquitin binding); This domain is found N terminal to pfam08324 and binds to ...
 346-457 2.11e-62

PFU (PLAA family ubiquitin binding); This domain is found N terminal to pfam08324 and binds to ubiquitin.


:

Pssm-ID: 462670  Cd Length: 111  Bit Score: 204.68  E-value: 2.11e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086659   346 PGNRDGQTRLIKEGSN-VEAYQWSMSDGRWMKIGDVVGGSSqqSSKRVMYEGKEYDFVFTIDVNEGGPPMKLPYNVTDDP 424
Cdd:pfam09070   1 PGKKEGQVKMVREGNGvVEAYQWSAAEQQWEKIGDVVGSAG--SSQKKEYEGKEYDYVFDVDIEDGKPPLKLPYNVGDNP 78

                          90       100       110
                  ....*....|....*....|....*....|...
gi 47086659   425 WLVAHNFLQKNDLSPMFLDQVANFIIENTKGHT 457
Cdd:pfam09070  79 YEAAQKFLARNELPQSYLDQVVNFIIKNTGGVT 111
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 9-297 1.59e-61

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 209.11  E-value: 1.59e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086659   9 LRSSLPAHDMDVRglaAVAF-PDGAF-VSVSRDRTARVWVPNPSEnqsftEMHCMNGHSNFVSCvCIISPNETYPrgltA 86
Cdd:cd00200   1 LRRTLKGHTGGVT---CVAFsPDGKLlATGSGDGTIKVWDLETGE-----LLRTLKGHTGPVRD-VAASADGTYL----A 67

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086659  87 TGGHDNNICVFSLDRPDPLFTLKGHKNTVCTLSAGKFGTIL-SGSWDTTAKVW--LGEKCMMTLQGHTAAVWAVLILPEQ 163
Cdd:cd00200  68 SGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILsSSSRDKTIKVWdvETGKCLTTLRGHTDWVNSVAFSPDG 147

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086659 164 GLMLSGSADKTIKLW--KAGRCEKTYTGHEDSVRGLAVIND-VEFFSCSNDASIRRW-MVTGECVQVYYGHTNYIYSIAV 239
Cdd:cd00200 148 TFVASSSQDGTIKLWdlRTGKCVATLTGHTGEVNSVAFSPDgEKLLSSSSDGTIKLWdLSTGKCLGTLRGHENGVNSVAF 227

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 47086659 240 FPNGKDFISTGEDRTLRVW--KEGECSQTIRLPAQSVWCCCILPNG-DIAVGASDGIIRVF 297
Cdd:cd00200 228 SPDGYLLASGSEDGTIRVWdlRTGECVQTLSGHTNSVTSLAWSPDGkRLASGSADGTIRIW 288
 
Name Accession Description Interval E-value
PUL pfam08324
PUL domain; The PUL (PLAP, Ufd3p and Lub1p) domain is a novel alpha-helical Ub-associated ...
 536-791 6.17e-71

PUL domain; The PUL (PLAP, Ufd3p and Lub1p) domain is a novel alpha-helical Ub-associated domain. It directly binds to Cdc48, a chaperone-like AAA ATPase that collects ubiquitylated substrates.


Pssm-ID: 462428  Cd Length: 261  Bit Score: 233.38  E-value: 6.17e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086659   536 PNTDGVMFEQSNTAQILGKLRELNTSAPADHKLSDAALDCLEKLLNLvteLPNLEQPTAEQITVLWRAC-HWPEDIVFPV 614
Cdd:pfam08324   1 PQKTYLSFKKANLDKILKKLGEFNGGEPKVLALSPEELATLEALLSF---LESSSSASEADIELLLKILtSWPPEDRFPA 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086659   615 LDILRLAVRHPEVNAHLCGGtEGASLCNHLLGLMSPEGKAANQMLALRTLCNCFTASHGRALLLGQRDAVLSRAGDLRTV 694
Cdd:pfam08324  78 LDLLRLLALDPRVAAYFAEE-EGGKTISTLLSLLISSGLYALRMLALRLLCNLFSSPLGRQLLLSHFDSILSTLASLLSS 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086659   695 C----NKNIHVALATLVLNYAGRLY--GQPAEIEAKAQCLSVASTALEVVQ-DKEAVFRLLVALGTTV--SGDSTAKDLA 765
Cdd:pfam08324 157 SlldsNKNLRIALATLLLNYAVLLHkeKSPLSEEDQVELLAALLEALSTEEeDSEALYRLLVALGTLVyaPDGEVLADLA 236

                         250       260
                  ....*....|....*....|....*.
gi 47086659   766 RSLGVNSQISKYARVSEPaKVGECCR 791
Cdd:pfam08324 237 QVLDAASWVKKAKKKKEP-RIKEVGS 261
PFU pfam09070
PFU (PLAA family ubiquitin binding); This domain is found N terminal to pfam08324 and binds to ...
 346-457 2.11e-62

PFU (PLAA family ubiquitin binding); This domain is found N terminal to pfam08324 and binds to ubiquitin.


Pssm-ID: 462670  Cd Length: 111  Bit Score: 204.68  E-value: 2.11e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086659   346 PGNRDGQTRLIKEGSN-VEAYQWSMSDGRWMKIGDVVGGSSqqSSKRVMYEGKEYDFVFTIDVNEGGPPMKLPYNVTDDP 424
Cdd:pfam09070   1 PGKKEGQVKMVREGNGvVEAYQWSAAEQQWEKIGDVVGSAG--SSQKKEYEGKEYDYVFDVDIEDGKPPLKLPYNVGDNP 78

                          90       100       110
                  ....*....|....*....|....*....|...
gi 47086659   425 WLVAHNFLQKNDLSPMFLDQVANFIIENTKGHT 457
Cdd:pfam09070  79 YEAAQKFLARNELPQSYLDQVVNFIIKNTGGVT 111
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 9-297 1.59e-61

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 209.11  E-value: 1.59e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086659   9 LRSSLPAHDMDVRglaAVAF-PDGAF-VSVSRDRTARVWVPNPSEnqsftEMHCMNGHSNFVSCvCIISPNETYPrgltA 86
Cdd:cd00200   1 LRRTLKGHTGGVT---CVAFsPDGKLlATGSGDGTIKVWDLETGE-----LLRTLKGHTGPVRD-VAASADGTYL----A 67

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086659  87 TGGHDNNICVFSLDRPDPLFTLKGHKNTVCTLSAGKFGTIL-SGSWDTTAKVW--LGEKCMMTLQGHTAAVWAVLILPEQ 163
Cdd:cd00200  68 SGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILsSSSRDKTIKVWdvETGKCLTTLRGHTDWVNSVAFSPDG 147

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086659 164 GLMLSGSADKTIKLW--KAGRCEKTYTGHEDSVRGLAVIND-VEFFSCSNDASIRRW-MVTGECVQVYYGHTNYIYSIAV 239
Cdd:cd00200 148 TFVASSSQDGTIKLWdlRTGKCVATLTGHTGEVNSVAFSPDgEKLLSSSSDGTIKLWdLSTGKCLGTLRGHENGVNSVAF 227

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 47086659 240 FPNGKDFISTGEDRTLRVW--KEGECSQTIRLPAQSVWCCCILPNG-DIAVGASDGIIRVF 297
Cdd:cd00200 228 SPDGYLLASGSEDGTIRVWdlRTGECVQTLSGHTNSVTSLAWSPDGkRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
8-296 2.22e-52

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 187.81  E-value: 2.22e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086659   8 RLRSSLPAHDMDVRglaAVAF-PDGAF-VSVSRDRTARVW-VPNPSENQSFTemhcmnGHSNFVSCVCIiSPNETYprgL 84
Cdd:COG2319 111 LLLRTLTGHTGAVR---SVAFsPDGKTlASGSADGTVRLWdLATGKLLRTLT------GHSGAVTSVAF-SPDGKL---L 177

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086659  85 tATGGHDNNICVFSLDRPDPLFTLKGHKNTVCTLS---AGKfgTILSGSWDTTAKVW--LGEKCMMTLQGHTAAVWAVLI 159
Cdd:COG2319 178 -ASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAfspDGK--LLASGSADGTVRLWdlATGKLLRTLTGHSGSVRSVAF 254

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086659 160 LPEQGLMLSGSADKTIKLWKA--GRCEKTYTGHEDSVRGLAVINDVEFF-SCSNDASIRRW-MVTGECVQVYYGHTNYIY 235
Cdd:COG2319 255 SPDGRLLASGSADGTVRLWDLatGELLRTLTGHSGGVNSVAFSPDGKLLaSGSDDGTVRLWdLATGKLLRTLTGHTGAVR 334

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 47086659 236 SIAVFPNGKDFISTGEDRTLRVW--KEGECSQTIRLPAQSVWCCCILPNGDIAVGAS-DGIIRV 296
Cdd:COG2319 335 SVAFSPDGKTLASGSDDGTVRLWdlATGELLRTLTGHTGAVTSVAFSPDGRTLASGSaDGTVRL 398
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 220-259 9.47e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.54  E-value: 9.47e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 47086659    220 TGECVQVYYGHTNYIYSIAVFPNGKDFISTGEDRTLRVWK 259
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
142-178 2.43e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.73  E-value: 2.43e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 47086659   142 KCMMTLQGHTAAVWAVLILPEQGLMLSGSADKTIKLW 178
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
PUL pfam08324
PUL domain; The PUL (PLAP, Ufd3p and Lub1p) domain is a novel alpha-helical Ub-associated ...
 536-791 6.17e-71

PUL domain; The PUL (PLAP, Ufd3p and Lub1p) domain is a novel alpha-helical Ub-associated domain. It directly binds to Cdc48, a chaperone-like AAA ATPase that collects ubiquitylated substrates.


Pssm-ID: 462428  Cd Length: 261  Bit Score: 233.38  E-value: 6.17e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086659   536 PNTDGVMFEQSNTAQILGKLRELNTSAPADHKLSDAALDCLEKLLNLvteLPNLEQPTAEQITVLWRAC-HWPEDIVFPV 614
Cdd:pfam08324   1 PQKTYLSFKKANLDKILKKLGEFNGGEPKVLALSPEELATLEALLSF---LESSSSASEADIELLLKILtSWPPEDRFPA 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086659   615 LDILRLAVRHPEVNAHLCGGtEGASLCNHLLGLMSPEGKAANQMLALRTLCNCFTASHGRALLLGQRDAVLSRAGDLRTV 694
Cdd:pfam08324  78 LDLLRLLALDPRVAAYFAEE-EGGKTISTLLSLLISSGLYALRMLALRLLCNLFSSPLGRQLLLSHFDSILSTLASLLSS 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086659   695 C----NKNIHVALATLVLNYAGRLY--GQPAEIEAKAQCLSVASTALEVVQ-DKEAVFRLLVALGTTV--SGDSTAKDLA 765
Cdd:pfam08324 157 SlldsNKNLRIALATLLLNYAVLLHkeKSPLSEEDQVELLAALLEALSTEEeDSEALYRLLVALGTLVyaPDGEVLADLA 236

                         250       260
                  ....*....|....*....|....*.
gi 47086659   766 RSLGVNSQISKYARVSEPaKVGECCR 791
Cdd:pfam08324 237 QVLDAASWVKKAKKKKEP-RIKEVGS 261
PFU pfam09070
PFU (PLAA family ubiquitin binding); This domain is found N terminal to pfam08324 and binds to ...
 346-457 2.11e-62

PFU (PLAA family ubiquitin binding); This domain is found N terminal to pfam08324 and binds to ubiquitin.


Pssm-ID: 462670  Cd Length: 111  Bit Score: 204.68  E-value: 2.11e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086659   346 PGNRDGQTRLIKEGSN-VEAYQWSMSDGRWMKIGDVVGGSSqqSSKRVMYEGKEYDFVFTIDVNEGGPPMKLPYNVTDDP 424
Cdd:pfam09070   1 PGKKEGQVKMVREGNGvVEAYQWSAAEQQWEKIGDVVGSAG--SSQKKEYEGKEYDYVFDVDIEDGKPPLKLPYNVGDNP 78

                          90       100       110
                  ....*....|....*....|....*....|...
gi 47086659   425 WLVAHNFLQKNDLSPMFLDQVANFIIENTKGHT 457
Cdd:pfam09070  79 YEAAQKFLARNELPQSYLDQVVNFIIKNTGGVT 111
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 9-297 1.59e-61

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 209.11  E-value: 1.59e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086659   9 LRSSLPAHDMDVRglaAVAF-PDGAF-VSVSRDRTARVWVPNPSEnqsftEMHCMNGHSNFVSCvCIISPNETYPrgltA 86
Cdd:cd00200   1 LRRTLKGHTGGVT---CVAFsPDGKLlATGSGDGTIKVWDLETGE-----LLRTLKGHTGPVRD-VAASADGTYL----A 67

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086659  87 TGGHDNNICVFSLDRPDPLFTLKGHKNTVCTLSAGKFGTIL-SGSWDTTAKVW--LGEKCMMTLQGHTAAVWAVLILPEQ 163
Cdd:cd00200  68 SGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILsSSSRDKTIKVWdvETGKCLTTLRGHTDWVNSVAFSPDG 147

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086659 164 GLMLSGSADKTIKLW--KAGRCEKTYTGHEDSVRGLAVIND-VEFFSCSNDASIRRW-MVTGECVQVYYGHTNYIYSIAV 239
Cdd:cd00200 148 TFVASSSQDGTIKLWdlRTGKCVATLTGHTGEVNSVAFSPDgEKLLSSSSDGTIKLWdLSTGKCLGTLRGHENGVNSVAF 227

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 47086659 240 FPNGKDFISTGEDRTLRVW--KEGECSQTIRLPAQSVWCCCILPNG-DIAVGASDGIIRVF 297
Cdd:cd00200 228 SPDGYLLASGSEDGTIRVWdlRTGECVQTLSGHTNSVTSLAWSPDGkRLASGSADGTIRIW 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 62-329 2.07e-56

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 195.25  E-value: 2.07e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086659  62 NGHSNFVSCVCIISPNETYprgltATGGHDNNICVFSLDRPDPLFTLKGHKNTVCTLSAGKFGT-ILSGSWDTTAKVW-- 138
Cdd:cd00200   6 KGHTGGVTCVAFSPDGKLL-----ATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTyLASGSSDKTIRLWdl 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086659 139 LGEKCMMTLQGHTAAVWAVLILPEQGLMLSGSADKTIKLW--KAGRCEKTYTGHEDSVRGLAVINDVEF-FSCSNDASIR 215
Cdd:cd00200  81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWdvETGKCLTTLRGHTDWVNSVAFSPDGTFvASSSQDGTIK 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086659 216 RW-MVTGECVQVYYGHTNYIYSIAVFPNGKDFISTGEDRTLRVW--KEGECSQTIRLPAQSVWCCCILPNGDIAVGAS-D 291
Cdd:cd00200 161 LWdLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWdlSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSeD 240

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 47086659 292 GIIRVF-TESEDRVasaQDLQAFEDELSKAVIDPKTGDL 329
Cdd:cd00200 241 GTIRVWdLRTGECV---QTLSGHTNSVTSLAWSPDGKRL 276
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-259 2.13e-53

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 186.77  E-value: 2.13e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086659   8 RLRSSLPAHDMDVRGLAAVAFpDGAFVSVSRDRTARVWvpNPSENQSFTEMHcmnGHSNFVSCVCIiSPNetypRGLTAT 87
Cdd:cd00200  42 ELLRTLKGHTGPVRDVAASAD-GTYLASGSSDKTIRLW--DLETGECVRTLT---GHTSYVSSVAF-SPD----GRILSS 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086659  88 GGHDNNICVFSLDRPDPLFTLKGHKNTVCTLSAGKFGTIL-SGSWDTTAKVW--LGEKCMMTLQGHTAAVWAVLILPEQG 164
Cdd:cd00200 111 SSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVaSSSQDGTIKLWdlRTGKCVATLTGHTGEVNSVAFSPDGE 190

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086659 165 LMLSGSADKTIKLW--KAGRCEKTYTGHEDSVRGLAVINDVEFF-SCSNDASIRRW-MVTGECVQVYYGHTNYIYSIAVF 240
Cdd:cd00200 191 KLLSSSSDGTIKLWdlSTGKCLGTLRGHENGVNSVAFSPDGYLLaSGSEDGTIRVWdLRTGECVQTLSGHTNSVTSLAWS 270

                       250
                ....*....|....*....
gi 47086659 241 PNGKDFISTGEDRTLRVWK 259
Cdd:cd00200 271 PDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
8-296 2.22e-52

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 187.81  E-value: 2.22e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086659   8 RLRSSLPAHDMDVRglaAVAF-PDGAF-VSVSRDRTARVW-VPNPSENQSFTemhcmnGHSNFVSCVCIiSPNETYprgL 84
Cdd:COG2319 111 LLLRTLTGHTGAVR---SVAFsPDGKTlASGSADGTVRLWdLATGKLLRTLT------GHSGAVTSVAF-SPDGKL---L 177

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086659  85 tATGGHDNNICVFSLDRPDPLFTLKGHKNTVCTLS---AGKfgTILSGSWDTTAKVW--LGEKCMMTLQGHTAAVWAVLI 159
Cdd:COG2319 178 -ASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAfspDGK--LLASGSADGTVRLWdlATGKLLRTLTGHSGSVRSVAF 254

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086659 160 LPEQGLMLSGSADKTIKLWKA--GRCEKTYTGHEDSVRGLAVINDVEFF-SCSNDASIRRW-MVTGECVQVYYGHTNYIY 235
Cdd:COG2319 255 SPDGRLLASGSADGTVRLWDLatGELLRTLTGHSGGVNSVAFSPDGKLLaSGSDDGTVRLWdLATGKLLRTLTGHTGAVR 334

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 47086659 236 SIAVFPNGKDFISTGEDRTLRVW--KEGECSQTIRLPAQSVWCCCILPNGDIAVGAS-DGIIRV 296
Cdd:COG2319 335 SVAFSPDGKTLASGSDDGTVRLWdlATGELLRTLTGHTGAVTSVAFSPDGRTLASGSaDGTVRL 398
WD40 COG2319
WD40 repeat [General function prediction only];
8-296 1.53e-47

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 173.94  E-value: 1.53e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086659   8 RLRSSLPAHDMDVRGLAAvaFPDGA-FVSVSRDRTARVW-VPNPSENQSFTemhcmnGHSNFVSCVCIiSPNETYprglT 85
Cdd:COG2319  69 ALLATLLGHTAAVLSVAF--SPDGRlLASASADGTVRLWdLATGLLLRTLT------GHTGAVRSVAF-SPDGKT----L 135

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086659  86 ATGGHDNNICVFSLDRPDPLFTLKGHKNTVCTLS---AGKfgTILSGSWDTTAKVW--LGEKCMMTLQGHTAAVWAVLIL 160
Cdd:COG2319 136 ASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAfspDGK--LLASGSDDGTVRLWdlATGKLLRTLTGHTGAVRSVAFS 213

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086659 161 PEQGLMLSGSADKTIKLW--KAGRCEKTYTGHEDSVRGLAVINDVEFF-SCSNDASIRRW-MVTGECVQVYYGHTNYIYS 236
Cdd:COG2319 214 PDGKLLASGSADGTVRLWdlATGKLLRTLTGHSGSVRSVAFSPDGRLLaSGSADGTVRLWdLATGELLRTLTGHSGGVNS 293

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 47086659 237 IAVFPNGKDFISTGEDRTLRVW--KEGECSQTIRLPAQSVWCCCILPNGDIAV-GASDGIIRV 296
Cdd:COG2319 294 VAFSPDGKLLASGSDDGTVRLWdlATGKLLRTLTGHTGAVRSVAFSPDGKTLAsGSDDGTVRL 356
WD40 COG2319
WD40 repeat [General function prediction only];
8-258 5.32e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 169.71  E-value: 5.32e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086659   8 RLRSSLPAHDMDVRglaAVAF-PDGAF-VSVSRDRTARVWvpnpsENQSFTEMHCMNGHSNFVSCVCIiSPNETYprgLt 85
Cdd:COG2319 153 KLLRTLTGHSGAVT---SVAFsPDGKLlASGSDDGTVRLW-----DLATGKLLRTLTGHTGAVRSVAF-SPDGKL---L- 219

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086659  86 ATGGHDNNICVFSLDRPDPLFTLKGHKNTVCTLSA---GKfgTILSGSWDTTAKVW--LGEKCMMTLQGHTAAVWAVLIL 160
Cdd:COG2319 220 ASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFspdGR--LLASGSADGTVRLWdlATGELLRTLTGHSGGVNSVAFS 297

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086659 161 PEQGLMLSGSADKTIKLWKA--GRCEKTYTGHEDSVRGLAVINDVEF-FSCSNDASIRRW-MVTGECVQVYYGHTNYIYS 236
Cdd:COG2319 298 PDGKLLASGSDDGTVRLWDLatGKLLRTLTGHTGAVRSVAFSPDGKTlASGSDDGTVRLWdLATGELLRTLTGHTGAVTS 377

                       250       260
                ....*....|....*....|..
gi 47086659 237 IAVFPNGKDFISTGEDRTLRVW 258
Cdd:COG2319 378 VAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
8-297 7.25e-42

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 157.77  E-value: 7.25e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086659   8 RLRSSLPAHDMDVRGLAAVAFPDGAFVSVSRDRTARVWVPNPSENQSFTemhcmnGHSNFVSCVcIISPNetypRGLTAT 87
Cdd:COG2319  27 ALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLL------GHTAAVLSV-AFSPD----GRLLAS 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086659  88 GGHDNNICVFSLDRPDPLFTLKGHKNTVCTLSA---GKfgTILSGSWDTTAKVW--LGEKCMMTLQGHTAAVWAVLILPE 162
Cdd:COG2319  96 ASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFspdGK--TLASGSADGTVRLWdlATGKLLRTLTGHSGAVTSVAFSPD 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086659 163 QGLMLSGSADKTIKLW--KAGRCEKTYTGHEDSVRGLAVIND---VefFSCSNDASIRRW-MVTGECVQVYYGHTNYIYS 236
Cdd:COG2319 174 GKLLASGSDDGTVRLWdlATGKLLRTLTGHTGAVRSVAFSPDgklL--ASGSADGTVRLWdLATGKLLRTLTGHSGSVRS 251

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 47086659 237 IAVFPNGKDFISTGEDRTLRVW--KEGECSQTIRLPAQSVWCCCILPNGD-IAVGASDGIIRVF 297
Cdd:COG2319 252 VAFSPDGRLLASGSADGTVRLWdlATGELLRTLTGHSGGVNSVAFSPDGKlLASGSDDGTVRLW 315
WD40 COG2319
WD40 repeat [General function prediction only];
8-180 7.32e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.93  E-value: 7.32e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086659   8 RLRSSLPAHDMDVRglaAVAF-PDGAF-VSVSRDRTARVWVPNPSEnqsftEMHCMNGHSNFVSCVCIiSPNETYprglT 85
Cdd:COG2319 237 KLLRTLTGHSGSVR---SVAFsPDGRLlASGSADGTVRLWDLATGE-----LLRTLTGHSGGVNSVAF-SPDGKL----L 303

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086659  86 ATGGHDNNICVFSLDRPDPLFTLKGHKNTVCTLSAGKFG-TILSGSWDTTAKVW--LGEKCMMTLQGHTAAVWAVLILPE 162
Cdd:COG2319 304 ASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGkTLASGSDDGTVRLWdlATGELLRTLTGHTGAVTSVAFSPD 383

                       170
                ....*....|....*...
gi 47086659 163 QGLMLSGSADKTIKLWKA 180
Cdd:COG2319 384 GRTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 223-338 2.21e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 59.27  E-value: 2.21e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086659 223 CVQVYYGHTNYIYSIAVFPNGKDFISTGEDRTLRVW--KEGECSQTIRLPAQSVWCCCILPNGD-IAVGASDGIIRVFTE 299
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWdlETGELLRTLKGHTGPVRDVAASADGTyLASGSSDKTIRLWDL 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 47086659 300 SEDRVASAqdLQAFEDELSKAVIDPK------TGDLGDIKIEELP 338
Cdd:cd00200  81 ETGECVRT--LTGHTSYVSSVAFSPDgrilssSSRDKTIKVWDVE 123
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 220-259 9.47e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.54  E-value: 9.47e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 47086659    220 TGECVQVYYGHTNYIYSIAVFPNGKDFISTGEDRTLRVWK 259
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 142-179 1.32e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.46  E-value: 1.32e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 47086659    142 KCMMTLQGHTAAVWAVLILPEQGLMLSGSADKTIKLWK 179
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
142-178 2.43e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.73  E-value: 2.43e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 47086659   142 KCMMTLQGHTAAVWAVLILPEQGLMLSGSADKTIKLW 178
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
221-258 4.38e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.95  E-value: 4.38e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 47086659   221 GECVQVYYGHTNYIYSIAVFPNGKDFISTGEDRTLRVW 258
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
104-138 7.13e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 7.13e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 47086659   104 PLFTLKGHKNTVCTLSAGKFGT-ILSGSWDTTAKVW 138
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKlLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 181-217 9.27e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 9.27e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 47086659    181 GRCEKTYTGHEDSVRGLAVINDVEFF-SCSNDASIRRW 217
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLaSGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
181-217 2.97e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 2.97e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 47086659   181 GRCEKTYTGHEDSVRGLAVINDVEFF-SCSNDASIRRW 217
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLaSGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 261-297 3.27e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 3.27e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 47086659    261 GECSQTIRLPAQSVWCCCILPNGD-IAVGASDGIIRVF 297
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKyLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 104-138 4.85e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 4.85e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 47086659    104 PLFTLKGHKNTVCTLSAGKFGTIL-SGSWDTTAKVW 138
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLaSGSDDGTIKLW 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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