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Conserved domains on  [gi|55742589|ref|NP_998343|]
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regulator of chromosome condensation [Danio rerio]

Protein Classification

RCC1-like domain-containing protein( domain architecture ID 20422823)

RCC1 (regulator of chromosome condensation)-like (RLD) domain-containing protein harbors a versatile domain which may perform many different functions, including guanine nucleotide exchange on small GTP-binding proteins, enzyme inhibition or interaction with proteins and lipids

Gene Ontology:  GO:0005085|GO:0007165
PubMed:  18442486

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 70-414 1.26e-59

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


:

Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 197.51  E-value: 1.26e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742589  70 VQAVAGGMHTVCLSDTGNVYTFGCNDEGALGRDTSeeGSETVPAKVDLGEKIIQVSAGDSHSAALTEDGGVYVWGSfrDN 149
Cdd:COG5184   1 TQVAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTT--TDRSTPVRVPGLSNVVAVAAGGDHTCALKADGTVWCWGN--NS 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742589 150 NGVIGLLEPMKKcTVPVKVPIDKPVVKIVSGNDHLVMLTAHGELYTSGCGEQGQLGRVAEhfANRGGrkglmrllePQMV 229
Cdd:COG5184  77 YGQLGDGTTTDR-TTPVKVPGLTGVVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTT--TNRLT---------PVQV 144

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742589 230 iikPRGKVVFTDVFCGAYFTFAVSKEGHVYGFGLSNYHQLGTQSTNTCFVPVKLSSFknstTSWVGFSGGQHHTLCLNSE 309
Cdd:COG5184 145 ---DAGLSGVVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVGGL----SGVVAVAAGGDHSCALKSD 217

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742589 310 GKAYSLGRAEYGRLGLGkDVGEKSEPTVVPGISDVQVVACGASVSYAVTKQGSVFSWGMGTNLQLGTGEEEDEWSPVEMT 389
Cdd:COG5184 218 GTVWCWGSNSSGQLGDG-TTTDRATPVQVAGLTGVVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVKVP 296

                       330       340
                ....*....|....*....|....*
gi 55742589 390 GkqLENrvVLSVSSGGQHTVLLVKD 414
Cdd:COG5184 297 G--LSG--VVAVAAGSSHTCALLTD 317
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
34-82 1.70e-06

Regulator of chromosome condensation (RCC1) repeat;


:

Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 44.82  E-value: 1.70e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 55742589    34 KGLVLVLGQGDVGQLGLGEDVmERKKPALVTLPEG--IVQAVAGGMHTVCL 82
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTE-NVLVPQKVEGLSGnkVVQVACGGDHTVAL 50
 
Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 70-414 1.26e-59

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 197.51  E-value: 1.26e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742589  70 VQAVAGGMHTVCLSDTGNVYTFGCNDEGALGRDTSeeGSETVPAKVDLGEKIIQVSAGDSHSAALTEDGGVYVWGSfrDN 149
Cdd:COG5184   1 TQVAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTT--TDRSTPVRVPGLSNVVAVAAGGDHTCALKADGTVWCWGN--NS 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742589 150 NGVIGLLEPMKKcTVPVKVPIDKPVVKIVSGNDHLVMLTAHGELYTSGCGEQGQLGRVAEhfANRGGrkglmrllePQMV 229
Cdd:COG5184  77 YGQLGDGTTTDR-TTPVKVPGLTGVVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTT--TNRLT---------PVQV 144

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742589 230 iikPRGKVVFTDVFCGAYFTFAVSKEGHVYGFGLSNYHQLGTQSTNTCFVPVKLSSFknstTSWVGFSGGQHHTLCLNSE 309
Cdd:COG5184 145 ---DAGLSGVVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVGGL----SGVVAVAAGGDHSCALKSD 217

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742589 310 GKAYSLGRAEYGRLGLGkDVGEKSEPTVVPGISDVQVVACGASVSYAVTKQGSVFSWGMGTNLQLGTGEEEDEWSPVEMT 389
Cdd:COG5184 218 GTVWCWGSNSSGQLGDG-TTTDRATPVQVAGLTGVVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVKVP 296

                       330       340
                ....*....|....*....|....*
gi 55742589 390 GkqLENrvVLSVSSGGQHTVLLVKD 414
Cdd:COG5184 297 G--LSG--VVAVAAGSSHTCALLTD 317
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
361-411 2.95e-10

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 55.22  E-value: 2.95e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 55742589   361 GSVFSWGMGTNLQLGTGEEEDEWSPVEMTGkqLENRVVLSVSSGGQHTVLL 411
Cdd:pfam00415   2 GRVYTWGRNDYGQLGLGTTENVLVPQKVEG--LSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
34-82 1.70e-06

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 44.82  E-value: 1.70e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 55742589    34 KGLVLVLGQGDVGQLGLGEDVmERKKPALVTLPEG--IVQAVAGGMHTVCL 82
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTE-NVLVPQKVEGLSGnkVVQVACGGDHTVAL 50
 
Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 70-414 1.26e-59

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 197.51  E-value: 1.26e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742589  70 VQAVAGGMHTVCLSDTGNVYTFGCNDEGALGRDTSeeGSETVPAKVDLGEKIIQVSAGDSHSAALTEDGGVYVWGSfrDN 149
Cdd:COG5184   1 TQVAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTT--TDRSTPVRVPGLSNVVAVAAGGDHTCALKADGTVWCWGN--NS 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742589 150 NGVIGLLEPMKKcTVPVKVPIDKPVVKIVSGNDHLVMLTAHGELYTSGCGEQGQLGRVAEhfANRGGrkglmrllePQMV 229
Cdd:COG5184  77 YGQLGDGTTTDR-TTPVKVPGLTGVVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTT--TNRLT---------PVQV 144

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742589 230 iikPRGKVVFTDVFCGAYFTFAVSKEGHVYGFGLSNYHQLGTQSTNTCFVPVKLSSFknstTSWVGFSGGQHHTLCLNSE 309
Cdd:COG5184 145 ---DAGLSGVVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVGGL----SGVVAVAAGGDHSCALKSD 217

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742589 310 GKAYSLGRAEYGRLGLGkDVGEKSEPTVVPGISDVQVVACGASVSYAVTKQGSVFSWGMGTNLQLGTGEEEDEWSPVEMT 389
Cdd:COG5184 218 GTVWCWGSNSSGQLGDG-TTTDRATPVQVAGLTGVVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVKVP 296

                       330       340
                ....*....|....*....|....*
gi 55742589 390 GkqLENrvVLSVSSGGQHTVLLVKD 414
Cdd:COG5184 297 G--LSG--VVAVAAGSSHTCALLTD 317
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 41-386 1.06e-55

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 187.11  E-value: 1.06e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742589  41 GQGDVGQLGLGeDVMERKKPALVTLPEGIVQAVAGGMHTVCLSDTGNVYTFGCNDEGALGRDTSeeGSETVPAKVDLGEK 120
Cdd:COG5184  23 GDNSYGQLGDG-TTTDRSTPVRVPGLSNVVAVAAGGDHTCALKADGTVWCWGNNSYGQLGDGTT--TDRTTPVKVPGLTG 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742589 121 IIQVSAGDSHSAALTEDGGVYVWGSfrDNNGVIGLLEPMKKcTVPVKVPI-DKPVVKIVSGNDHLVMLTAHGELYTSGCG 199
Cdd:COG5184 100 VVAVAAGYYHSCALKSDGTVWCWGD--NSSGQLGDGTTTNR-LTPVQVDAgLSGVVAIAAGGYHTCALKSDGTVWCWGAN 176

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742589 200 EQGQLGRVaeHFANRggrkglmrlLEPQMViikpRGKVVFTDVFCGAYFTFAVSKEGHVYGFGLSNYHQLGTQSTNTCFV 279
Cdd:COG5184 177 SYGQLGDG--TTTDR---------PTPVQV----GGLSGVVAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTTTDRAT 241

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742589 280 PVKLSSFknstTSWVGFSGGQHHTLCLNSEGKAYSLGRAEYGRLGLGkDVGEKSEPTVVPGISDVQVVACGASVSYAVTK 359
Cdd:COG5184 242 PVQVAGL----TGVVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDG-TTTDRSTPVKVPGLSGVVAVAAGSSHTCALLT 316

                       330       340
                ....*....|....*....|....*..
gi 55742589 360 QGSVFSWGMGTNLQLGTGEEEDEWSPV 386
Cdd:COG5184 317 DGTVWCWGDNAYGQLGDGTTTDRSTPV 343
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 35-206 1.22e-26

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 109.30  E-value: 1.22e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742589  35 GLVLVLGQGDVGQLGLGeDVMERKKPALVTLPEGIVQAVAGGMHTVCLSDTGNVYTFGCNDEGALGRDTSeeGSETVPAK 114
Cdd:COG5184 168 GTVWCWGANSYGQLGDG-TTTDRPTPVQVGGLSGVVAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTT--TDRATPVQ 244

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742589 115 VDLGEKIIQVSAGDSHSAALTEDGGVYVWGsfRDNNGVIGLLEPMKKcTVPVKVPIDKPVVKIVSGNDHLVMLTAHGELY 194
Cdd:COG5184 245 VAGLTGVVAIAAGGSHTCALKSDGTVWCWG--DNSYGQLGDGTTTDR-STPVKVPGLSGVVAVAAGSSHTCALLTDGTVW 321

                       170
                ....*....|..
gi 55742589 195 TSGCGEQGQLGR 206
Cdd:COG5184 322 CWGDNAYGQLGD 333
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
361-411 2.95e-10

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 55.22  E-value: 2.95e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 55742589   361 GSVFSWGMGTNLQLGTGEEEDEWSPVEMTGkqLENRVVLSVSSGGQHTVLL 411
Cdd:pfam00415   2 GRVYTWGRNDYGQLGLGTTENVLVPQKVEG--LSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
255-306 5.31e-10

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 54.45  E-value: 5.31e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 55742589   255 EGHVYGFGLSNYHQLGTQSTNTCFVPVKLSSFKNSttSWVGFSGGQHHTLCL 306
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGN--KVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
86-134 5.80e-10

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 54.45  E-value: 5.80e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 55742589    86 GNVYTFGCNDEGALGRDTSEegSETVPAKV--DLGEKIIQVSAGDSHSAAL 134
Cdd:pfam00415   2 GRVYTWGRNDYGQLGLGTTE--NVLVPQKVegLSGNKVVQVACGGDHTVAL 50
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
121-145 7.79e-07

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 45.11  E-value: 7.79e-07
                          10        20
                  ....*....|....*....|....*
gi 55742589   121 IIQVSAGDSHSAALTEDGGVYVWGS 145
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGD 25
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
34-82 1.70e-06

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 44.82  E-value: 1.70e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 55742589    34 KGLVLVLGQGDVGQLGLGEDVmERKKPALVTLPEG--IVQAVAGGMHTVCL 82
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTE-NVLVPQKVEGLSGnkVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
309-357 7.55e-05

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 40.19  E-value: 7.55e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 55742589   309 EGKAYSLGRAEYGRLGLGKDVgEKSEPTVVPGISD--VQVVACGASVSYAV 357
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTE-NVLVPQKVEGLSGnkVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
191-252 1.27e-04

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 39.42  E-value: 1.27e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 55742589   191 GELYTSGCGEQGQLGRVAEHfanrggrkglmRLLEPQMVIIKPRGKVVftDVFCGAYFTFAV 252
Cdd:pfam00415   2 GRVYTWGRNDYGQLGLGTTE-----------NVLVPQKVEGLSGNKVV--QVACGGDHTVAL 50
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
239-268 4.35e-04

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 37.40  E-value: 4.35e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 55742589   239 FTDVFCGAYFTFAVSKEGHVYGFGLSNYHQ 268
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
69-97 4.43e-04

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 37.40  E-value: 4.43e-04
                          10        20
                  ....*....|....*....|....*....
gi 55742589    69 IVQAVAGGMHTVCLSDTGNVYTFGCNDEG 97
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYG 29
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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