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Conserved domains on  [gi|190610002|ref|NP_998763|]
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zinc finger protein 543 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

CATH:  3.30.160.60
Gene Ontology:  GO:0003700|GO:0046872
PubMed:  22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
9-69 1.91e-29

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 110.37  E-value: 1.91e-29
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 190610002     9 VTFEDVAVTFTQEEWGQLDAAQRTLYQEVMLETCGLLMSLGCPLFKPELIYQLDHRQELWM 69
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
223-562 6.22e-14

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 74.35  E-value: 6.22e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190610002 223 QVKPYECTECGKTFSKSTHLLQHLIIHTGEKPYKCM--ECGKAFNRRSHLTRHQRIHSGE-------------------- 280
Cdd:COG5048   30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNpsdlnskslplsnskassss 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190610002 281 ---------KPYKCSECGKAFTHRSTFVLHHRSHTGEKPFVCKECGKAFRDRPGFIRHYIIHTGEkpyecIECGKAFNRR 351
Cdd:COG5048  110 lsssssnsnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAN-----SLSKDPSSNL 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190610002 352 SYLTwHQQIHTGVKPFECNECGKAFCESADLIQHYIIHTGEKPYKCMECGKAFNRrsHLKQHQRIHTGeKPYECSECGKA 431
Cdd:COG5048  185 SLLI-SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPK--SLLSQSPSSLS-SSDSSSSASES 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190610002 432 FTHCSTFVLHKRTH----------TGEKPYECKECGKAFSDRADLIRHF--SIHTGE--KPYECVE--CGKAFNRSSHLT 495
Cdd:COG5048  261 PRSSLPTASSQSSSpnesdsssekGFSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALK 340

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190610002 496 RHQQIHTGEKPYECI-------------------------------------QCGKAFCRSANLIRHSIIHTGEKPYEC- 537
Cdd:COG5048  341 RHILLHTSISPAKEKllnssskfspllnneppqslqqykdlkndkksetlsnSCIRNFKRDSNLSLHIITHLSFRPYNCk 420

                        410       420
                 ....*....|....*....|....*.
gi 190610002 538 -SECGKAFNRGSSLTHHQRIHTGRNP 562
Cdd:COG5048  421 nPPCSKSFNRHYNLIPHKKIHTNHAP 446
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
75-329 1.37e-04

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.69  E-value: 1.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190610002  75 SQSSYPGDNTKPkTTEPTFSHLALPEEVLLQEQLTQGASKNSQLgqSKDQDGPSEMQEVHLKIGIGPQRGKLLEKMSSER 154
Cdd:COG5048  207 SSYSIPSSSSDQ-NLENSSSSLPLTTNSQLSPKSLLSQSPSSLS--SSDSSSSASESPRSSLPTASSQSSSPNESDSSSE 283

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190610002 155 DGLGSDDgVCTKITQKQvSTEGDL---YECDSHgpvtdalIREEKNSYKCEE--CGKVFKKNALLVQHERIHTQVKPYEC 229
Cdd:COG5048  284 KGFSLPI-KSKQCNISF-SRSSPLtrhLRSVNH-------SGESLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKE 354

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190610002 230 --TECGKTFSKSTH--LLQHLIIHTGEKPYK---CM--ECGKAFNRRSHLTRH--QRIHSGEKPYKCSECGKAFThRSTF 298
Cdd:COG5048  355 klLNSSSKFSPLLNnePPQSLQQYKDLKNDKkseTLsnSCIRNFKRDSNLSLHiiTHLSFRPYNCKNPPCSKSFN-RHYN 433

                        250       260       270
                 ....*....|....*....|....*....|.
gi 190610002 299 VLHHRSHTGEKPFVCKECGKAFRDRPGFIRH 329
Cdd:COG5048  434 LIPHKKIHTNHAPLLCSILKSFRRDLDLSNH 464
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
9-69 1.91e-29

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 110.37  E-value: 1.91e-29
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 190610002     9 VTFEDVAVTFTQEEWGQLDAAQRTLYQEVMLETCGLLMSLGCPLFKPELIYQLDHRQELWM 69
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 8-49 5.97e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 88.68  E-value: 5.97e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 190610002    8 SVTFEDVAVTFTQEEWGQLDAAQRTLYQEVMLETCGLLMSLG 49
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 9-48 7.51e-19

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 79.90  E-value: 7.51e-19
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 190610002   9 VTFEDVAVTFTQEEWGQLDAAQRTLYQEVMLETCGLLMSL 48
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
223-562 6.22e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 74.35  E-value: 6.22e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190610002 223 QVKPYECTECGKTFSKSTHLLQHLIIHTGEKPYKCM--ECGKAFNRRSHLTRHQRIHSGE-------------------- 280
Cdd:COG5048   30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNpsdlnskslplsnskassss 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190610002 281 ---------KPYKCSECGKAFTHRSTFVLHHRSHTGEKPFVCKECGKAFRDRPGFIRHYIIHTGEkpyecIECGKAFNRR 351
Cdd:COG5048  110 lsssssnsnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAN-----SLSKDPSSNL 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190610002 352 SYLTwHQQIHTGVKPFECNECGKAFCESADLIQHYIIHTGEKPYKCMECGKAFNRrsHLKQHQRIHTGeKPYECSECGKA 431
Cdd:COG5048  185 SLLI-SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPK--SLLSQSPSSLS-SSDSSSSASES 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190610002 432 FTHCSTFVLHKRTH----------TGEKPYECKECGKAFSDRADLIRHF--SIHTGE--KPYECVE--CGKAFNRSSHLT 495
Cdd:COG5048  261 PRSSLPTASSQSSSpnesdsssekGFSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALK 340

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190610002 496 RHQQIHTGEKPYECI-------------------------------------QCGKAFCRSANLIRHSIIHTGEKPYEC- 537
Cdd:COG5048  341 RHILLHTSISPAKEKllnssskfspllnneppqslqqykdlkndkksetlsnSCIRNFKRDSNLSLHIITHLSFRPYNCk 420

                        410       420
                 ....*....|....*....|....*.
gi 190610002 538 -SECGKAFNRGSSLTHHQRIHTGRNP 562
Cdd:COG5048  421 nPPCSKSFNRHYNLIPHKKIHTNHAP 446
zf-H2C2_2 pfam13465
Zinc-finger double domain;
409-434 6.85e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.74  E-value: 6.85e-06
                          10        20
                  ....*....|....*....|....*.
gi 190610002  409 HLKQHQRIHTGEKPYECSECGKAFTH 434
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
75-329 1.37e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.69  E-value: 1.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190610002  75 SQSSYPGDNTKPkTTEPTFSHLALPEEVLLQEQLTQGASKNSQLgqSKDQDGPSEMQEVHLKIGIGPQRGKLLEKMSSER 154
Cdd:COG5048  207 SSYSIPSSSSDQ-NLENSSSSLPLTTNSQLSPKSLLSQSPSSLS--SSDSSSSASESPRSSLPTASSQSSSPNESDSSSE 283

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190610002 155 DGLGSDDgVCTKITQKQvSTEGDL---YECDSHgpvtdalIREEKNSYKCEE--CGKVFKKNALLVQHERIHTQVKPYEC 229
Cdd:COG5048  284 KGFSLPI-KSKQCNISF-SRSSPLtrhLRSVNH-------SGESLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKE 354

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190610002 230 --TECGKTFSKSTH--LLQHLIIHTGEKPYK---CM--ECGKAFNRRSHLTRH--QRIHSGEKPYKCSECGKAFThRSTF 298
Cdd:COG5048  355 klLNSSSKFSPLLNnePPQSLQQYKDLKNDKkseTLsnSCIRNFKRDSNLSLHiiTHLSFRPYNCKNPPCSKSFN-RHYN 433

                        250       260       270
                 ....*....|....*....|....*....|.
gi 190610002 299 VLHHRSHTGEKPFVCKECGKAFRDRPGFIRH 329
Cdd:COG5048  434 LIPHKKIHTNHAPLLCSILKSFRRDLDLSNH 464
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
9-69 1.91e-29

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 110.37  E-value: 1.91e-29
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 190610002     9 VTFEDVAVTFTQEEWGQLDAAQRTLYQEVMLETCGLLMSLGCPLFKPELIYQLDHRQELWM 69
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 8-49 5.97e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 88.68  E-value: 5.97e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 190610002    8 SVTFEDVAVTFTQEEWGQLDAAQRTLYQEVMLETCGLLMSLG 49
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 9-48 7.51e-19

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 79.90  E-value: 7.51e-19
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 190610002   9 VTFEDVAVTFTQEEWGQLDAAQRTLYQEVMLETCGLLMSL 48
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
223-562 6.22e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 74.35  E-value: 6.22e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190610002 223 QVKPYECTECGKTFSKSTHLLQHLIIHTGEKPYKCM--ECGKAFNRRSHLTRHQRIHSGE-------------------- 280
Cdd:COG5048   30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNpsdlnskslplsnskassss 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190610002 281 ---------KPYKCSECGKAFTHRSTFVLHHRSHTGEKPFVCKECGKAFRDRPGFIRHYIIHTGEkpyecIECGKAFNRR 351
Cdd:COG5048  110 lsssssnsnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAN-----SLSKDPSSNL 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190610002 352 SYLTwHQQIHTGVKPFECNECGKAFCESADLIQHYIIHTGEKPYKCMECGKAFNRrsHLKQHQRIHTGeKPYECSECGKA 431
Cdd:COG5048  185 SLLI-SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPK--SLLSQSPSSLS-SSDSSSSASES 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190610002 432 FTHCSTFVLHKRTH----------TGEKPYECKECGKAFSDRADLIRHF--SIHTGE--KPYECVE--CGKAFNRSSHLT 495
Cdd:COG5048  261 PRSSLPTASSQSSSpnesdsssekGFSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALK 340

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190610002 496 RHQQIHTGEKPYECI-------------------------------------QCGKAFCRSANLIRHSIIHTGEKPYEC- 537
Cdd:COG5048  341 RHILLHTSISPAKEKllnssskfspllnneppqslqqykdlkndkksetlsnSCIRNFKRDSNLSLHIITHLSFRPYNCk 420

                        410       420
                 ....*....|....*....|....*.
gi 190610002 538 -SECGKAFNRGSSLTHHQRIHTGRNP 562
Cdd:COG5048  421 nPPCSKSFNRHYNLIPHKKIHTNHAP 446
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
253-593 1.73e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.81  E-value: 1.73e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190610002 253 KPYKCMECGKAFNRRSHLTRHQRIHSGEKPYKCS--ECGKAFTHRSTFVLHHRSHTGEKPFVCKecgKAFRDRPGFIRHY 330
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNS---KSLPLSNSKASSS 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190610002 331 IIhtgekpyecIECGKAFNRRSYL---TWHQQIHTGVKPFE-------------CNECGKAFCESADLIQHYIIHtgekp 394
Cdd:COG5048  109 SL---------SSSSSNSNDNNLLsshSLPPSSRDPQLPDLlsisnlrnnplpgNNSSSVNTPQSNSLHPPLPAN----- 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190610002 395 ykcMECGKAFNRRSHLKQHQRIHTGEKPYECSECGKA--FTHCSTFvlHKRTHTgEKPYECKECGKAFSDRADLIRHFSI 472
Cdd:COG5048  175 ---SLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSysIPSSSSD--QNLENS-SSSLPLTTNSQLSPKSLLSQSPSSL 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190610002 473 HTGEKPYECVECGKAFNRSSHLTRHQQIHTGE-------KPYECIQCGKAFCRSANLIRH--SIIHTGE--KPYECSE-- 539
Cdd:COG5048  249 SSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYsl 328

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....
gi 190610002 540 CGKAFNRGSSLTHHQRIHTGRNPtivtdvgRPFMTAQTSVNIQELLLGKEFLNI 593
Cdd:COG5048  329 CGKLFSRNDALKRHILLHTSISP-------AKEKLLNSSSKFSPLLNNEPPQSL 375
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
197-430 1.28e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.40  E-value: 1.28e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190610002 197 NSYKCEECGKVFKKNALLVQHERIHTQVKPYECTECGKTFSKSTHLLQHLIIHTGE-------KPYKCMECGKAFNRRSH 269
Cdd:COG5048  225 SSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSP 304

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190610002 270 LTRHQR--IHSGE--KPYKCSE--CGKAFTHRSTFVLHHRSHTGEKPFVCKEC-------GKAFRDRPGFIRHYIIHTGE 336
Cdd:COG5048  305 LTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKND 384

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190610002 337 KPYECI--ECGKAFNRRSYLTWHQQIHTGVKPFECnecgkafcesadliqhyiihtgekpyKCMECGKAFNRRSHLKQHQ 414
Cdd:COG5048  385 KKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNC--------------------------KNPPCSKSFNRHYNLIPHK 438

                        250
                 ....*....|....*.
gi 190610002 415 RIHTGEKPYECSECGK 430
Cdd:COG5048  439 KIHTNHAPLLCSILKS 454
zf-H2C2_2 pfam13465
Zinc-finger double domain;
409-434 6.85e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.74  E-value: 6.85e-06
                          10        20
                  ....*....|....*....|....*.
gi 190610002  409 HLKQHQRIHTGEKPYECSECGKAFTH 434
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
197-353 1.94e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.38  E-value: 1.94e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190610002 197 NSYKCEECGKVFKKNALLVQHER--IHTQ--VKPYECTE--CGKTFSKSTHLLQHLIIHTGEKPYKCMEC------GKAF 264
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGesLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfSPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190610002 265 NRRSHLTRHQRIHSGEKPYKC---SECGKAFTHRSTFVLHHRSHTGEKPFVCK--ECGKAFRDRPGFIRHYIIHTGEKPY 339
Cdd:COG5048  368 NNEPPQSLQQYKDLKNDKKSEtlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        170
                 ....*....|....
gi 190610002 340 ECIECGKAFNRRSY 353
Cdd:COG5048  448 LCSILKSFRRDLDL 461
zf-H2C2_2 pfam13465
Zinc-finger double domain;
269-294 1.96e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 1.96e-05
                          10        20
                  ....*....|....*....|....*.
gi 190610002  269 HLTRHQRIHSGEKPYKCSECGKAFTH 294
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
241-266 6.92e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 6.92e-05
                          10        20
                  ....*....|....*....|....*.
gi 190610002  241 HLLQHLIIHTGEKPYKCMECGKAFNR 266
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
521-546 8.51e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 8.51e-05
                          10        20
                  ....*....|....*....|....*.
gi 190610002  521 NLIRHSIIHTGEKPYECSECGKAFNR 546
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
75-329 1.37e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.69  E-value: 1.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190610002  75 SQSSYPGDNTKPkTTEPTFSHLALPEEVLLQEQLTQGASKNSQLgqSKDQDGPSEMQEVHLKIGIGPQRGKLLEKMSSER 154
Cdd:COG5048  207 SSYSIPSSSSDQ-NLENSSSSLPLTTNSQLSPKSLLSQSPSSLS--SSDSSSSASESPRSSLPTASSQSSSPNESDSSSE 283

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190610002 155 DGLGSDDgVCTKITQKQvSTEGDL---YECDSHgpvtdalIREEKNSYKCEE--CGKVFKKNALLVQHERIHTQVKPYEC 229
Cdd:COG5048  284 KGFSLPI-KSKQCNISF-SRSSPLtrhLRSVNH-------SGESLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKE 354

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190610002 230 --TECGKTFSKSTH--LLQHLIIHTGEKPYK---CM--ECGKAFNRRSHLTRH--QRIHSGEKPYKCSECGKAFThRSTF 298
Cdd:COG5048  355 klLNSSSKFSPLLNnePPQSLQQYKDLKNDKkseTLsnSCIRNFKRDSNLSLHiiTHLSFRPYNCKNPPCSKSFN-RHYN 433

                        250       260       270
                 ....*....|....*....|....*....|.
gi 190610002 299 VLHHRSHTGEKPFVCKECGKAFRDRPGFIRH 329
Cdd:COG5048  434 LIPHKKIHTNHAPLLCSILKSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
493-516 1.47e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.47e-04
                          10        20
                  ....*....|....*....|....
gi 190610002  493 HLTRHQQIHTGEKPYECIQCGKAF 516
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
441-461 2.87e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.87e-04
                          10        20
                  ....*....|....*....|.
gi 190610002  441 HKRTHTGEKPYECKECGKAFS 461
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
381-406 3.46e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.46e-04
                          10        20
                  ....*....|....*....|....*.
gi 190610002  381 DLIQHYIIHTGEKPYKCMECGKAFNR 406
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 255-277 4.41e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.66  E-value: 4.41e-04
                          10        20
                  ....*....|....*....|...
gi 190610002  255 YKCMECGKAFNRRSHLTRHQRIH 277
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
328-350 5.76e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.76e-04
                          10        20
                  ....*....|....*....|...
gi 190610002  328 RHYIIHTGEKPYECIECGKAFNR 350
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 335-418 7.03e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 7.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190610002 335 GEKPYEC--IECGKAFNRRSYLTWHQqIHtgvkpfecNECGKAFCESADLIQHYIIHTGEKPYKCMECGKAFNRRSHLKQ 412
Cdd:COG5189  346 DGKPYKCpvEGCNKKYKNQNGLKYHM-LH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 190610002 413 HqRIHT 418
Cdd:COG5189  417 H-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
214-238 8.04e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 8.04e-04
                          10        20
                  ....*....|....*....|....*
gi 190610002  214 LVQHERIHTQVKPYECTECGKTFSK 238
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 395-417 8.59e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.89  E-value: 8.59e-04
                          10        20
                  ....*....|....*....|...
gi 190610002  395 YKCMECGKAFNRRSHLKQHQRIH 417
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
353-376 1.66e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.66e-03
                          10        20
                  ....*....|....*....|....
gi 190610002  353 YLTWHQQIHTGVKPFECNECGKAF 376
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 479-501 1.96e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 1.96e-03
                          10        20
                  ....*....|....*....|...
gi 190610002  479 YECVECGKAFNRSSHLTRHQQIH 501
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
301-320 4.62e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.62e-03
                          10        20
                  ....*....|....*....|
gi 190610002  301 HHRSHTGEKPFVCKECGKAF 320
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
465-490 4.81e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.81e-03
                          10        20
                  ....*....|....*....|....*.
gi 190610002  465 DLIRHFSIHTGEKPYECVECGKAFNR 490
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 535-557 9.05e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 9.05e-03
                          10        20
                  ....*....|....*....|...
gi 190610002  535 YECSECGKAFNRGSSLTHHQRIH 557
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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