|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
10-417 |
0e+00 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 664.80 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 10 RATIFLAMFVGYTLYYFNRKTFSFVMPSVMQEITLDKDDLGLITSSQSLAYAISKFISGVLSDQMSARWLFSIGLFTVGG 89
Cdd:cd17343 1 QLTIFASMFVGYTLYYFNRKSFSFVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 90 INVIFSQSSSVAVFSGLWFLNGLGQGLGWPPCAKVLRKWFEPSQFGTWWAVLSCSMNLAGCLGPIIATLMAQSYSWRSTL 169
Cdd:cd17343 81 TTVAFSGSSSVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSYGWRSTL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 170 SISGLTCVVTSIFCLIIIRNEPSEVGLPNIEAGAKKGK-GGSSKNESTFKEFIFSPYLWLMSLGYLVVFGVKTAYTDWGQ 248
Cdd:cd17343 161 SISGTVAVVMSVVCLLFIKNEPSDVGLNNIEEEESKGKkKKSPRGESTLKELLLSPFLWLLSLGYLVVFGVKTAVTDWGQ 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 249 LFLIQDKGQSALMGSSFMSALEIGGLLGSLAAGFLSDRAVAKHGLRLYGNPRHGLLLSMMAGMCVSMYLFRTTVTAHSSN 328
Cdd:cd17343 241 LFLIQDKGQSALTGSSFMSSLEVGGFVGSIAAGYLSDWAVAKHGSSSRGNPRMPLALVFMAGLTVSLHLFRVHITSDSSE 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 329 VWILLLGAAFGFSSYGPIALFGVLANESAPSNYCGTSHAIVALMANVGGFLSGLPFGTVAKHHGWNTAFWVAEIACMVTT 408
Cdd:cd17343 321 LFILLLGFLIGFSLYGPIAIFGVIANESAPSHLCGTSHAIVALAANVGGVLAGLPFSYIAKHYDWRTAFLLLEILCAITV 400
|
....*....
gi 47550765 409 VGYFLLRNI 417
Cdd:cd17343 401 VILFLLRNI 409
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
18-397 |
3.07e-125 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 367.47 E-value: 3.07e-125
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 18 FVGYTLYYFNRKTFSFVMPSVMQEITLDKDDLGLITSSQSLAYAISKFISGVLSDQMSARWLFSIGLFTVGGINVIFSQS 97
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 98 SSVAVFSGLWFLNGLGQGLGWPPCAKVLRKWFEPSQFGTWWAVLSCSMNLAGCLGPIIATL-MAQSYSWRSTLSISGLTC 176
Cdd:TIGR00881 81 TSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFgIAELYSWHWVFIVPGIIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 177 VVTSIFCLIIIRNEPSEVGLPNIE--------AGAKKGKGGSSKNESTFKEFIFSPYLWLMSLGYLVVFGVKTAYTDWGQ 248
Cdd:TIGR00881 161 IIVSLICFLLLRDSPQSCGLPPAEempneepdGDAEKKEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVRTGILDWSP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 249 LFLIQDKGQSALMGSSFMSALEIGGLLGSLAAGFLSDravakhglRLYGNPRHGLLLSMMAGMCVSMYLFRTTVTAhsSN 328
Cdd:TIGR00881 241 LYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSD--------KLFNGRRGPLAVFFMALIIVSLLVYWLNPAA--NP 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 47550765 329 VWILLLGAAFGFSSYGPIALFGVLANESAPSNYCGTSHAIVALMANVGGFLSGLPFGTVAKHHGWNTAF 397
Cdd:TIGR00881 311 LMDLICLFALGFLVYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFGWAGAF 379
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
13-415 |
3.13e-103 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 310.75 E-value: 3.13e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 13 IFLAMFVGYTLYYFNRKTFSFVMPSVMQEITLDKDDLGLITSSQSLAYAISKFISGVLSDQMSARWLFSIGLFTVGGINV 92
Cdd:cd17312 4 IFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 93 IFSQSSSVAVFSGLWFLNGLGQGLGWPPCAKVLRKWFEPSQFGTWWAVLSCSMNLAGCLGPIIATLMAQSYSWRSTLSIS 172
Cdd:cd17312 84 FMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVP 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 173 GLTCVVTSIFCLIIIRNEPsevglpnieagakkgkggssknestfkefifsPYLWLMSLGYLVVFGVKTAYTDWGQLFLI 252
Cdd:cd17312 164 GIVGLVVAIILFFFLRDSP--------------------------------PYVWVLSLAYAFVYIVRYACLDWGPLYLY 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 253 QDKGQSALMGSSFMSALEIGGLLGSLAAGFLSDravakhglRLYGNPRHGLLLSMMAGMCVSMYLFRTTVtahSSNVWIL 332
Cdd:cd17312 212 EVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSD--------KLFGGRRAPIAVIYMLLMTLSLALFWFFP---HNKLLSI 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 333 LLGAAFGFSSYGPIALFGVLANESAPSNY-CGTSHAIVALMANVGGFLSGLPFGTVAKHHGWNTAFWVAEIACMVTTVGY 411
Cdd:cd17312 281 VLLFLIGFFVGGPINLIGGAAAQDIGRKEaAGTATGFVGLFGYLGASLAGLPLGYIIDHYGWSTVFYFLISAALLSVLLL 360
|
....
gi 47550765 412 FLLR 415
Cdd:cd17312 361 LSLW 364
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
6-414 |
2.94e-79 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 251.55 E-value: 2.94e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 6 YGYYRATIFLAMFVGYTLYYFNRKTFSFVMPSVMQEITLDKDDLGLITSSQSLAYAISKFISGVLSDQMSARWLFSIGLF 85
Cdd:PRK11663 17 YRYWRRHILITMYLGYALFYFTRKSFNAAMPEMLADLGLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 86 TVGGINVIFSQSSSVAVFSGLWFLNGLGQGLGWPPCAKVLRKWFEPSQFGTWWAVLSCSMNLAGCLGPIIATLMAQSYSW 165
Cdd:PRK11663 97 ATGIINILFGFSSSLWAFALLWVLNAFFQGWGWPVCAKLLTAWYSRTERGGWWAIWNTAHNVGGALIPLVVGAIALHYGW 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 166 RSTLSISGLTCVVTSIFCLIIIRNEPSEVGLPNI--------EAGAKKGKGGSSKNESTFKEFIFSPYLWLMSLGYLVVF 237
Cdd:PRK11663 177 RYGMMIAGIIAIVVGLFLCWRLRDKPQAMGLPSVgewrhdalELAQQQEGAGLSRKEILTKYVLLNPYIWLLSFSYVLVY 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 238 GVKTAYTDWGQLFLIQDKGQSALMGSSFMSALEIGGLLGSLAAGFLSDravakhglRLYGNPRHGLLLSMMAGMCVSMYL 317
Cdd:PRK11663 257 VVRAAINDWGNLYMSETLGVDLVTANSAVSMFELGGFIGALVAGWGSD--------KLFNGNRGPMNLIFAAGILLSVGS 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 318 FRTTVTAHssnvwILLLGAAF---GFSSYGPIALFGVLANESAPSNYCGTSHAIVALMANVGGFLSGLPFGTVAKHHGWN 394
Cdd:PRK11663 329 LWLMPFAS-----YVMQAACFftiGFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYLGAALSGYPLAKVLEIWHWT 403
|
410 420
....*....|....*....|
gi 47550765 395 TAFWVaeIACMVTTVGYFLL 414
Cdd:PRK11663 404 GFFVV--ISIAAGISALLLL 421
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
10-409 |
2.00e-71 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 229.21 E-value: 2.00e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 10 RATIFLAMFVGYTLYYFNRKTFSFVMPSVMQEITLDKDDLGLITSSQSLAYAISKFISGVLSDQMSARWLFSIGLFTVGG 89
Cdd:cd17488 1 RIHILASMFIGYAVFYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 90 INVIFSQSSSVAVFSGLWFLNGLGQGLGWPPCAKVLRKWFEPSQFGTWWAVLSCSMNLAGCLGPIIATLMAQSYSWRSTL 169
Cdd:cd17488 81 INILFGFSSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTYGWRAGM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 170 SISGLTCVVTSIFCLIIIRNEPsevglpnieagakkgkggssknestfkefifsPYLWLMSLGYLVVFGVKTAYTDWGQL 249
Cdd:cd17488 161 YVPGIIAILMGIVLCWRLRDRP--------------------------------PYIWLLAFCYVLVYVVRTAINDWGNL 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 250 FLIQDKGQSALMGSSFMSALEIGGLLGSLAAGFLSDravakhglRLYGNPRHGLLLSMMAGMCVSMYLFRTTVTAHssnv 329
Cdd:cd17488 209 YLSETHGYSLVKANSAVSLFEVGGLIGALVAGWGSD--------KLFKGNRGPMNLIFALGLLVSVGALWLVPVHS---- 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 330 WILLLGAAF--GFSSYGPIALFGVLANESAPSNYCGTSHAIVALMANVGGFLSGLPFGTVAKHHGWNTAFWVAEIACMVT 407
Cdd:cd17488 277 YWLLATCFFtiGFFVFGPQMLIGMAAAECSHKDAAGSATGFVGLFAYLGAALAGYPLAKVIESWGWSGFFIVISIAAAIS 356
|
..
gi 47550765 408 TV 409
Cdd:cd17488 357 GL 358
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
10-415 |
2.68e-69 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 225.20 E-value: 2.68e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 10 RATIFLAMFVGYTLYYFNRKTFSFVMPSVMQEITLDKDDLGLITSSQSLAYAISKFISGVLSDQMSARWLFSIGLFTVGG 89
Cdd:cd17345 1 RWQVFLGIFIGYAGYYLVRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 90 INVIF----SQSSSVAVFSGLWFLNGLGQGLGWPPCAKVLRKWFEPSQFGTWWAVLSCSMNLAGCLGPIIATLMAQ---S 162
Cdd:cd17345 81 INILIgfvpSATSSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAifgD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 163 YSWRSTLSISGLTCVVTSIFCLIIIRNEPSEVGLPNIE-----AGAKKGKGGSSKNEST---FKEFIF-SPYLWLMSLG- 232
Cdd:cd17345 161 GWWRGAFIFPAIIAIIVAVIVLFLGKDTPESEGLPPIEeykgdYPEEADGEEEEQELSAweiFVKYVLkNKLLWYIAIAn 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 233 ---YLVVFGVktayTDWGQLFLIQDKGQSALMGSSFMSALEIGGLLGSLAAGFLSDravakhglRLYGNPRhglllSMMA 309
Cdd:cd17345 241 vfvYLVRYGI----LDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSD--------KLFKGRR-----APTG 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 310 GMCVSMYLFRTTVTAHSSNVWILLLGAAF-GFSSYGPIALFGVLANESAPSNYCGTSHAIVALMANVGG-FLSGLPFGTV 387
Cdd:cd17345 304 IIFMILVIVALIVYWLAPNVLVDLIALIAlGFLIYGPVMLIGLQALELVPKKAAGTAAGLTGLFGYLGGsVLATALIGII 383
|
410 420
....*....|....*....|....*...
gi 47550765 388 AKHHGWNTAFWVAEIACMVTTVGYFLLR 415
Cdd:cd17345 384 VDHFGWNGGFIVLLASCILAIIFLALVA 411
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
3-415 |
1.31e-56 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 190.47 E-value: 1.31e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 3 KTGYGYYRATIFLAMFVGYTLYYFNRKTFSFVMPSVMQEITLDKDDLGLITSSQSLAYAISKFISGVLSDQMSARWLFSI 82
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 83 GLFTVGGINVIFSQSSSVAVFSGLWFLNGLGQGLGWPPCAKVLRKWFEPSQFGTWWAVLSCSMNLAGCLGPIIATLMAQS 162
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 163 YSWRSTLSISGLTCVVTSIFcliiirnepsevglpnieagakkgkggssknestfkefifspYLWLMSLGYLVVFGVKTA 242
Cdd:COG2271 161 FGWRAAFLILGLPGLLLALL------------------------------------------RFWLLALAYFLVYFALYG 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 243 YTDWGQLFLIQDKGQSALMGSSFMSALEIGGLLGSLAAGFLSDRavakhglrlYGNPRHGLLLSMMAGMCVSMYLFRTTv 322
Cdd:COG2271 199 FLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDR---------LGRRRKLVLAIGLLLAALALLLLALL- 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 323 tahSSNVWILLLGAAFGFSSYGPIALFGVLANESAPSNYCGTSHAIVALMANVGGFLSGLPFGTVAKHHGWNTAFWVAEI 402
Cdd:COG2271 269 ---PSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAA 345
|
410
....*....|...
gi 47550765 403 ACMVTTVGYFLLR 415
Cdd:COG2271 346 LALLAALLALLLL 358
|
|
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
6-409 |
1.64e-38 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 144.47 E-value: 1.64e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 6 YGYYRATIFLAMFVGYTLYYFNRKTFSFVMPSVMQEiTLDKDDLGLITSSQSLAYAISKFISGVLSDQMSARWLFSIGLF 85
Cdd:PRK11273 23 YRRLRWQIFLGIFFGYAAYYLVRKNFALAMPYLVEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLI 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 86 TVGGINVIFS----QSSSVAVFSGLWFLNGLGQGLGWPPCAKVLRKWFEPSQFGTWWAVLSCSMNLAGCLGPIIATL-MA 160
Cdd:PRK11273 102 LAAAVMLFMGfvpwATSSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGLPPLLFLLgMA 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 161 QSYSWRSTLSISGLTCVVTSIFCLIIIRNEPSEVGLPNIEAGAK---KGKGGSSKNESTFKEfIFSPY------LWLMSL 231
Cdd:PRK11273 182 WFNDWHAALYMPAFAAILVALFAFAMMRDTPQSCGLPPIEEYKNdypDDYNEKHEQELTAKQ-IFMQYvlpnklLWYIAI 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 232 GYLVVFGVKTAYTDWGQLFLIQDKGqSALMGSSFMSAL-EIGGLLGSLAAGFLSDRAvakhglrLYGNprhglllSMMAG 310
Cdd:PRK11273 261 ANVFVYLLRYGILDWSPTYLKEVKH-FALDKSSWAYFLyEYAGIPGTLLCGWMSDKV-------FRGN-------RGATG 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 311 McvsmyLFRTTVTAHSSNVWI---------LLLGAAFGFSSYGPIALFGVLANESAPSNYCGTSHAIVALMANVGGFLSG 381
Cdd:PRK11273 326 V-----FFMTLVTIATIVYWLnpagnptvdMACMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVAA 400
|
410 420
....*....|....*....|....*....
gi 47550765 382 -LPFGTVAKHHGWNTAFWVAEIACMVTTV 409
Cdd:PRK11273 401 sAIVGYTVDFFGWDGGFMVMIGGSILAVI 429
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
9-415 |
1.33e-34 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 132.70 E-value: 1.33e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 9 YRATIFLAMFVGYTLYYFNRKTFSFVMPSVMQEITLDKDDLGLITSSQSLAYAISKFISGVLSDQMSARWLFSIGLFTVG 88
Cdd:COG2223 2 GRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 89 GINVIFSQSSSVAVFSGLWFLNGLGQGLGWPPCAKVLRKWFEPSQFGTWWAVLSCSMNLAGCLGPIIATLMAQSYSWRST 168
Cdd:COG2223 82 IGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 169 LSISGLTCVVTSIFCLIIIRNEPSEVGLPnieagakkgkggSSKNESTFKEFIFSPYLWLMSLGYLVVFGVKTAYTDWGQ 248
Cdd:COG2223 162 FLILGILLLVVAVLAWLFLRDPPAGAAAA------------AKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLP 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 249 LFLIQDKGQSALMGSSFMSALEIGGLLGSLAAGFLSDRAvakhglrlygnPRHGLLLSMMAGMCVSMYLFrttVTAHSSN 328
Cdd:COG2223 230 PYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRI-----------GGRRVLLIVFALMALGLLLL---ALALGSL 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 329 VWILLLGAAFGFSSYGPIALFGVLANESAPSNYCGTSHAIVALMANVGGFLSGLPFGTVAKHHG-WNTAFWVAEIACMVT 407
Cdd:COG2223 296 WLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVA 375
|
....*...
gi 47550765 408 TVGYFLLR 415
Cdd:COG2223 376 LVLTLLLY 383
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
10-414 |
6.36e-31 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 121.52 E-value: 6.36e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 10 RATIFLAMFVGYTLYYFNRKTFSFVMPSVMQEITLDKDDLGLITSSQSLAYAISKFISGVLSDQMSARWLFSIGLFTVGG 89
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 90 INVIFSQSSSVAVFSGLWFLNGLGQGLGWPPCAKVLRKWFEPSQFGTWWAVLSCSMNLAGCLGPIIATLMAQSYSWRSTL 169
Cdd:cd17319 81 FTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 170 SISGLTCVVTSIFCLIIIRNepsevglpnieagakkgkggssknestfkefifspyLWLMSLGYLVVFGVKTAYTDWGQL 249
Cdd:cd17319 161 IIEGLLGLLLAVLWWFYLRQ------------------------------------VWGLALGYFGINYALYGLLTWLPT 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 250 FLIQDKGQSaLMGSSFMSALE-IGGLLGSLAAGFLSDravakhglRLYGNPRHGLLLSMMAGMCVSMYLFrttVTAHSSN 328
Cdd:cd17319 205 YLKQARGFS-LKQVGLLAAIPfLAGAIGMILGGRLSD--------RLLRGARRLVIIIGLLLAAVGLLLA---YLTTSPV 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 329 VWILLLGAAFGFsSYGPIALFGVLANESAPSNYCGTSHAIVALMANVGGFLSGLPFGT-VAKHHGWNTAFWVAEIACMVT 407
Cdd:cd17319 273 VAVILLSLAGFG-IGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYlVDATGSYTAAFLFLAAVALLA 351
|
....*..
gi 47550765 408 TVGYFLL 414
Cdd:cd17319 352 ALLVLLL 358
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
17-380 |
8.42e-29 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 115.59 E-value: 8.42e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 17 MFVGYTLYYFNRKTFSFVMPSVM-QEITLDKDDLGLITSSQSLAYAISKFISGVLSDQMSARWLFSIGLFTVGGINVIFS 95
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLaEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 96 QSSSVAVFSGLWFLNGLGQGLGWPPCAKVLRKWFEPSQFGTWWAVLSCSMNLAGCLGPIIATLMAQSYSWRSTLSISGLT 175
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 176 CVVTSIFCLIIIRNEPSEVGLPNIEAGAKKGKGgssknestFKEFIFSPYLWLMsLGYLVVFGVKTAYTDWGQLFlIQDK 255
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLSLIVA--------WKALLRDPVLWLL-LALLLFGFAFFGLLTYLPLY-QEVL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 256 GQSALMGSSFMSALEIGGLLGSLAAGFLSDRAVAKHGLRlygnprhgLLLSMMAGMCVSMYLFRTTVTAHSSNVWILLLG 335
Cdd:pfam07690 231 GLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLL--------LALLLLILAALGLLLLSLTLSSLWLLLALLLLG 302
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 47550765 336 AAFGFSsygpIALFGVLANESAPSNYCGTSHAIVALMANVGGFLS 380
Cdd:pfam07690 303 FGFGLV----FPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
8-380 |
9.06e-29 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 115.46 E-value: 9.06e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 8 YYRATIFLAMFVGYTLYYFNRKTFSFVMPSVMQEITLDKDDLGLITSSQSLAYAISKFISGVLSDQMSARWLFSIGLFTV 87
Cdd:COG2814 6 RRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 88 GGINVIFSQSSSVAVFSGLWFLNGLGQGLGWPPCAKVLRKWFEPSQFGTWWAVLSCSMNLAGCLGPIIATLMAQSYSWRS 167
Cdd:COG2814 86 ALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRW 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 168 TLSISGLTCVVTSIFCLIIIRNEPSEVglpnieagakkgkggSSKNESTFKEFIFSPYLWLMSLGYLVVFGVKTAYTDWG 247
Cdd:COG2814 166 VFLVNAVLALLALLLLLRLLPESRPAA---------------RARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 248 QLFLIQDKGQSALMGSSFMSALEIGGLLGSLAAGFLSDRAvakhglrlygnPRHGLLLSMMAGMCVSMYLFrttvtAHSS 327
Cdd:COG2814 231 PLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRF-----------GRRRLLLIGLLLLALGLLLL-----ALAG 294
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 47550765 328 NVWILLLGAA-FGFSSYGPIALFGVLANESAPSNYCGTSHAIVALMANVGGFLS 380
Cdd:COG2814 295 SLWLLLLALFlLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
17-412 |
2.14e-27 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 112.13 E-value: 2.14e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 17 MFVGYTLYYFNRKTFSFVMPSVMQEITLDKDDLGLITSSQSLAYAISKFISGVLSDQMSARWLFSIGLFTVGGINVIFSQ 96
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 97 SSSVAVFSGLWFLNGLGQGLGWPPCAKVLRKWFEPSQFGTWWAVLSCSMNLAGCLGPIIATLMAQ--SYSWRSTLSISGL 174
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASslGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 175 TCVVTSIFCLIIIRNEPSEVGLPNIEAGAKKGKGGssknestFKEFIFSPYLWLMSLGYLVVFGVKTAYTDWGQLFLIQD 254
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEASSKSVLKL-------LKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 255 KGQSALMGSSFMSALEIGGLLGSLAAGFLSDRavakhglrlyGNPRHGLLLSMMAGMCVSMYLFrttvTAHSSNVWILLL 334
Cdd:cd06174 234 GGLSVAVAGLLLSLFGLAGALGSLLLGLLSDR----------LIGRKPLLLIGLLLMALGLALL----LLAPSLLLLLLL 299
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 47550765 335 GAAFGFSSYGPIALFGVLANESAPSNYCGTSHAIVALMANVGGFLSGLPFGTV-AKHHGWNTAFWVAEIACMVTTVGYF 412
Cdd:cd06174 300 LLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLlAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
14-419 |
9.87e-24 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 102.82 E-value: 9.87e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 14 FLAMFVGYTLYYFNRKTFSFVMPSVMQEITLDKDDLGLITSSQSLAYAISKFISGVLSDQMSARWLFSIGLFTVGGINVI 93
Cdd:PRK09556 31 YLVVFIGYLTMYLIRKNFKAAQNDMISTYGLSTTELGMIGLGFSITYGVGKTLVGYYADGKNTKQFLPFLLILSAICMLG 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 94 FS-----QSSSVAVFSGLWFLNGLGQGLGWPPCAKVLRKWFEPSQFGTWWAVLSCSMNLAGCLGPIIATLMAQSY---SW 165
Cdd:PRK09556 111 FGaslgsGSVSLGLMIALWALSGFFQSTGGPCSYSTITRWTPRRKRGRFLGFWNISHNLGGAGAGGVALWGANYFfdgHV 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 166 RSTLSISGLTCVVTSIFCLIIIRNEPSEVGL---------PNIEAGAKKGKGGSSKNEsTFKEF-IFSPYLWLMSLGYLV 235
Cdd:PRK09556 191 IGMFIFPSIIALIIGFIGLRYGSDSPEELGWgkaeeifgePISEEDKETESTDMTKWQ-IFVEYvLKNPVIWLLCFANIF 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 236 VFGVKTAYTDWGQLFLIQDKGQSALMGSSFMSALEIGGLLGSLAAGFLSDRAvakhglrlygNPRHGLLlsmmAGMCVSM 315
Cdd:PRK09556 270 LYIVRIGIDNWSPVYAFQELGFSKEDAINTFTLFEIGALVGSLLWGWLSDLA----------NGRRALV----ACIALAL 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 316 YLFRTTVTAHSSNVWILLLGA-AFGFSSYGPIALFGVLANESAPSN--------------YCGTSHAIVALMANVGGFLS 380
Cdd:PRK09556 336 IIFTLGVYQHATSEYMYLASLfALGFLVFGPQLLIGVAAVGFVPKKaigvangikgtfayLFGDSFAKVGLGMIADPTKN 415
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 47550765 381 GLP-FGTVAkhHGWN---TAFWVAEIACMV--TTVGYFLLRNIRT 419
Cdd:PRK09556 416 GTPiFGYTL--TGWAgtfAALDIAAIGCIClmAIVAVMEERKIRR 458
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
36-413 |
2.53e-22 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 97.69 E-value: 2.53e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 36 PSVMQEITLDKDDLGLITSSQSLAYAISKFISGVLSDQMSARWLFSIGLFTVGGINVIFSQSSSVAVFSGLWFLNGLGQG 115
Cdd:cd17475 20 PFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 116 LGWPPCAKVLRKWFEPSQFGTWWAVLSCSMNLAGCLGPIIATLMAQSYSWRSTLSISGLTCVVTSIFCLIIIRNEPSEVG 195
Cdd:cd17475 100 SVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREPPAASA 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 196 LPNIEAGAKKGKggssknestfKEFIFSPYLWLMSLGYLVVFGVKTAYTDWGQLFLIQDKGQSALMGSSFMSALEIGGLL 275
Cdd:cd17475 180 ATESASTLLRSL----------KEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGAL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 276 GSLAAGFLSDRAVAkhGLRLygnprhgLLLSMMAGMCVSMYLFRTTVTAHSSNVWILLLGAAFGFSSYGPIALFGVLANE 355
Cdd:cd17475 250 GRIGLGRVSDRVFG--GRRR-------PVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGWNGLYLTLVAE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 47550765 356 SAPSNYCGTSHAIVALMANVGGFLSGLPFG-TVAKHHGWNTAfWVAEIACMVTTVGYFL 413
Cdd:cd17475 321 SAGPEQAGTALGLANTINFIGIAIGPPLFGlLVDATHSYAPA-WLALALLLVLAALLLL 378
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
13-415 |
3.02e-19 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 88.79 E-value: 3.02e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 13 IFLAMFVGYTLYYfnrkTFSFVMPSVMQEITLDKDDLGLITSSQSLAYAISKFISGVLSDQMSARWLFSIGLFTVGGINV 92
Cdd:cd17325 1 LSLALFLDMLGYG----IIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 93 IFSQSSSVAVFSGLWFLNGLGQGLGWPPCAKVLRKWFEPSQFGTWWAVLSCSMNLAGCLGPIIATLMAQSYSWRSTLSIS 172
Cdd:cd17325 77 LFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVC 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 173 GLTCVVTSIFCLIIIRNEPSEvglpnieagAKKGKGGSSKNESTFKEFIFSPYLWLMSLGYLVVFGVKTAYTDWGQLFLI 252
Cdd:cd17325 157 AALALLALVLALLLLPEPRPP---------PNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAA 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 253 QDKGQSALMGSSFMSALEIGGLLGSLAAGFLSDRAvakhglrlygnPRHGLLLSMMAGMCVSMYLFrttvtAHSSNVWIL 332
Cdd:cd17325 228 ELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRI-----------GRKPLILIGLLLSAVALLLL-----PLATSFWLL 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 333 LLGAAF---GFSSYGPiALFGVLANESAPSNYcGTSHAIVALMANVGGFLSGLPFGTVAKHHGWNTAFWVAEIACMVTTV 409
Cdd:cd17325 292 LLLLALlglGLGLVFP-ATLALLADIVPPEGR-GTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAV 369
|
....*.
gi 47550765 410 GYFLLR 415
Cdd:cd17325 370 LFLLLR 375
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
34-416 |
3.88e-19 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 88.78 E-value: 3.88e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 34 VMPSVMQEITLDKDDLGLITSSQSLAYAISKFISGVLSDQMSARWLFSIGLFTVGGINVIFSQSSSVAVFSGLWFLNGLG 113
Cdd:COG2807 40 LLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAG 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 114 QGLGWPPCAKVLRKWFePSQFGTWWAVLSCSMNLAGCLGPIIATLMAQSYSWRSTLSISGLTCVVTSIFCLIIIRNEPSE 193
Cdd:COG2807 120 IAVGNVLLPGLIKRWF-PDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAA 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 194 vglpnieagakkgkGGSSKNESTFKEFIFSPYLWLMSLGYLVVFGVKTAYTDWGQLFLiQDKGQSALMGSSFMSALEIGG 273
Cdd:COG2807 199 --------------AAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPIL-RDAGLSAATAGLLLSLFQLAG 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 274 LLGSLAAGFLSDRAvakhglrlygNPRHGLLLSMMAGMCVSMYLFrTTVTAHSSNVWILLLGAAFGfssyGPIALFGVLA 353
Cdd:COG2807 264 IPGSLLVPLLADRL----------GDRRPLLLLLGLLGLAGLLGL-LLAPGSLPWLWAVLLGLGQG----GLFPLALTLI 328
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 47550765 354 NESAPSNycGTSHAIVALMANVGGFLSGL-PFGTVAKH---HGWNTAFWVAEIACMVTTV-GYFLLRN 416
Cdd:COG2807 329 GLRARTP--AEAAALSGMAQSVGYLLAALgPLLVGALHdatGSWTAALLLLAALAVLMLVaGLLAGRP 394
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
11-406 |
3.05e-18 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 85.79 E-value: 3.05e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 11 ATIFLAMFVGYTLyyfnRKTFSFVMPSVMQEITLDKDDLGLITSSQSLAYAISKFISGVLSDQMSARWLFSIGLFTVGGI 90
Cdd:cd17355 6 AVTFLILILSWGI----RYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 91 NVIFSQSSSVAVFSGLWFLNGLGQ--GLGWPPCAKVLRKWFEPSQfGTWWAVLSCSMNLAGCLGPIIATLMAQSYSWRST 168
Cdd:cd17355 82 LVLLALATSLWQLYLLWGLLGGGGagTLAAVAFATVAAWWFERRR-GLALGILTAGGGLGSLVFLPLGAALIEAFGWRTA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 169 LSISGLTCVVTSIFCLIIIRNEPSEVGLPNIEAGAKKGkggsskNESTFKEFIFSPYLWLMSLGYLVVfGVKTAYTDWGQ 248
Cdd:cd17355 161 LLVLALLALLVLVPVLLLLRRRPADLALRAYDDASPAS------PGSTLKEALRSASFWLLALAFFLC-GFAVVGLIVHL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 249 LFLIQDKGQSALMGSSFMSALEIGGLLGSLAAGFLSDRavakhglrlyGNPRHGLLLSMMAGMCVSMYLFRTTVTAHssn 328
Cdd:cd17355 234 VPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDR----------YSPRRLLAASYALRALGLALLLLLPFPPL--- 300
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 47550765 329 vWILLLGAAFGFSSYGPIALFGVLANESAPSNYCGTSHAIVALMANVGGFLSGLPFGTVAKHHGWNTAFWVAEIACMV 406
Cdd:cd17355 301 -ALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGL 377
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
14-414 |
1.11e-16 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 81.12 E-value: 1.11e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 14 FLAMFVGYTLYYFNRKTFSFVMPSVMQEITLDKDDLGLITSSQSLAYAISKFISGVLSDQMSARWL-----FSIGLFTVG 88
Cdd:cd06173 1 FRLLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLliladLLRALLAAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 89 GINVIFSQSSSVAVFSGLWFLNGLGQGLGWPPCAKVLRKWFEPSQFGTWWAVLSCSMNLAGCLGPIIATLMAQSYSWRST 168
Cdd:cd06173 81 LALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 169 LSISGLTCVVTSIFCLIIIRNEPSEVGLPNIEAGAKKGKGgssknestFKEFIFSPYLWLMSLGYLVVFGVKTAYTDWGQ 248
Cdd:cd06173 161 FAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLREG--------LRYLRRSPLLRLLLLALALFALLGGALTVLLP 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 249 LFLIQDKGQSALMGSSFMSALEIGGLLGSLAAGFLSDRavakhglrlygNPRHGLLLSMMAGMCVSMYLFrttvtAHSSN 328
Cdd:cd06173 233 LLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKR-----------RRRGRLLLIGALLLGLALLVL-----GLSPS 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 329 VWILLLGAAFGFSSYGPI-ALFGVLANESAPSNYCGTSHAIVALMANVGGFLSGLPFGTVAKHHGWNTAFWVAEIACMVT 407
Cdd:cd06173 297 LWLLLAALFLLGLAGGLFnVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLA 376
|
....*..
gi 47550765 408 TVGYFLL 414
Cdd:cd06173 377 ALLLLLL 383
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
34-420 |
1.46e-15 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 77.97 E-value: 1.46e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 34 VMPSVMQEITLDKDDLGLITSSQSLAYAISKFISGVLSDQMSARWLFSIGLFTVGGINVIFSQSSSVAVFSGLWFLNGLG 113
Cdd:COG0738 30 LIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLG 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 114 QGLGWPPCAKVLRkWFEPSQFGTWWAVLSCSMNLAGCLGPIIATLMAQ---SYSWRSTLSISGLTCVVTSIFCLIiirne 190
Cdd:COG0738 110 LGLLDVAANPYVA-ALGPETAASRLNLLHAFFSLGALLGPLLGGLLILlglSLSWHLPYLILAVLLLLLALLFLR----- 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 191 pseVGLPNIEAGAKKGKGGSSKNESTFKEfifsPYLWLMSLGYLVVFGVKTAYTDWGQLFLIQDKGQSALMGSSFMSALE 270
Cdd:COG0738 184 ---SKLPEIEEEEEEAAGSAASLKSLLKN----PRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFW 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 271 IGGLLGSLAAGFLSDRAvakhglrlygnPRHGLLLSMMAGMCVSMYLFRTTVTAHSSNVWILLLGaaFGFSSYGPIALfg 350
Cdd:COG0738 257 GGMTIGRFLGGFLLKRF-----------GPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVG--LGLSLMFPTIF-- 321
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 47550765 351 VLANESAPSNYCGTShAIVALMANVGGFLSGLPFGTVAKHHGWNTAFWVAEIAC-MVTTVGYFLLRNIRTK 420
Cdd:COG0738 322 SLALDGLGKRTAAAV-SAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYlLILLLALALKRKRRKK 391
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
17-347 |
5.19e-15 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 76.12 E-value: 5.19e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 17 MFVGYTLYYFNRKTFSFVMPSVMQEITLDKDDLGLITSSQSLAYAISKFISGVLSDQMSARWLFSIGLFTVGGINVIFSQ 96
Cdd:cd17328 4 LFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSF 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 97 SSSVAVFSGLWFLNGLGQGLGWPPCAKVLRKWFEPSQFGTWWAVLSCSMNLAGCLGPIIATLMAQS-YSWRSTLSISGLT 175
Cdd:cd17328 84 APNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQAtGGWRWAFRVTGVL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 176 CVVTSIFCLIIIRNEPSevglpnieAGAKKGKGGSSKNESTF---KEFIFSPYLWLMSLGYLVVFGVKTAYTDWGQLFL- 251
Cdd:cd17328 164 GVLLAILLLLFVREPPR--------GAAEGGVMAKSTATSFLadlKALAKNPSFILSTLGFTAVSFVTGALAFWAPTFFl 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 252 ---IQDKGQSALMGSSFMSALEIGGLLGSLAAGFLSDRAVAKhglrlygNPRHGLLLSMMaGMCVSMYLFRTTVTAHSSN 328
Cdd:cd17328 236 rafGVGDLSSADVGLIFGAITCIAGVLGVLLGGILADRLRRK-------TPRADPLVCAV-GLLAAAPFLFLALVLALSN 307
|
330 340
....*....|....*....|...
gi 47550765 329 VW----ILLLGAAFGFSSYGPIA 347
Cdd:cd17328 308 LLlawvLLFLGEFLLSLNWAPVF 330
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
14-414 |
8.82e-14 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 72.33 E-value: 8.82e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 14 FLAMFVGYTLYYFNRKTFSFVMPSVMQEITLDKDDLGLITSSQSLAYAISKFISGVLSDQMSAR--WLFSIGLFTVGGIN 91
Cdd:cd17371 1 FWAAFLGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVrvLVITILLFAVFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 92 VIFSQssSVAVFSGLWFLNGLGQGLGWPPCAKVLRKWFEPSQFGTWWAVLSCSMNLAGCLGPIIATLMAQ----SYSWRS 167
Cdd:cd17371 81 CGFAQ--NYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPllppEIAWRV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 168 TLsisgLTCVVTSIFCLIIIRNepsevgLPNIEAGAKKGKGGSSKNESTFKEFIFSP-YLWLMSLGYLVVFGVKTAY--- 243
Cdd:cd17371 159 LF----LLGALPALLVLFIRRF------VKEPPQWQAARAARRHFADRPSLRELFSPpLLRTTLLASLLATGALGGYygi 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 244 TDWGQLFLIQDKGQSALMGSSFMSALEIGGLLGSLAAGFLSDRavakhglrlYGNPRHGLLLSMMAGMCVSMYLFrttvt 323
Cdd:cd17371 229 TTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADR---------IGRRNNFALFALGSAISILLYFF----- 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 324 AHSSNVWILLLGAAFGFSSYGPIALFGVLANESAPSNYCGTSHAIVALMANVGGFLSGLPFGTVAKHHGWNTAF-WVAEI 402
Cdd:cd17371 295 LPLSPTLILILGFPLGFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLATSGSLGTAIaVFAAV 374
|
410
....*....|..
gi 47550765 403 ACMVTTVGYFLL 414
Cdd:cd17371 375 YYIAGLVLALLL 386
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
34-402 |
1.07e-13 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 71.82 E-value: 1.07e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 34 VMPSVMQEITLDKDDLGLITSSQSLAYAISKFISGVLSDQMSARWLFSIGLFTVGGINVIFSQSSSVAVFSGLWFLNGLG 113
Cdd:cd17478 18 LLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 114 QGLGWPPCAKVLRKwFEPSQFGTWWAVLSCSMNLAGCLGPIIATLMAQSYSWRSTLSISGLTCVVTSIFCLIIIRnepse 193
Cdd:cd17478 98 SAAFHPEGARLASQ-AAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRP----- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 194 vglPNIEAGAKKGKGGSSKNESTFKEFIFSPYLWLMSLGYLVVFGVKTAYTdwgqlFLIQDKGQSALMGSSFMSALEIGG 273
Cdd:cd17478 172 ---LKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLP-----FYLVQRGYSLVFAGLLLSLFLFAG 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 274 LLGSLAAGFLSDRavakHGLRLygnprhgLLLSMMAGMCVSMYLFrttvtAHSSNVWILLLGAAFGFSSYGPIALFGVLA 353
Cdd:cd17478 244 AIGTLIGGPLSDR----FGRRR-------VIIASLLLAAPFLLLF-----LLTPGIWSYILLVLAGFLLFASFPVTVVLA 307
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 47550765 354 NESAPsNYCGTSHAIVALMANVGGFLSGLPFGTVAKHHGWNTAFWVAEI 402
Cdd:cd17478 308 QELLP-GNVGLASGLMMGLSFGLGGIGAPVLGALADAFGLESVLLILAL 355
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
14-382 |
3.16e-12 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 67.77 E-value: 3.16e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 14 FLAMFV-GYTLyyfnrKTFSFVMPSVMQEITLDKDDLGLITSSQSLAYAISKFISGVLSDQMSARWLFSIGLFTVGGINV 92
Cdd:TIGR00895 23 FLIMLMdGYDL-----AAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 93 IFSQSSSVAVFSGLWFLNGLGQGlGWPPCAKVLRKWFEPSQF-GTWWAVLSCSMNLAGCLGPIIATLMAQSYSWRSTLSI 171
Cdd:TIGR00895 98 LCALATNVTQLLILRFLAGLGLG-GLMPNLNALVSEYAPKRFrGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYV 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 172 SGLTCVVTSIFCLI--------IIRNEPSEVG------LPNIEAGAKKGKGGSSKNESTFKEF---IFS-------PYLW 227
Cdd:TIGR00895 177 GGIAPLLLLLLLMRflpesidfLVSKRPETVRrivnaiAPQMQAEAQSALPEQKSTQGTKRSVfkaLFQgktaritVLLW 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 228 LM-SLGYLVVFGVktayTDWGQlFLIQDKGQSALMGSSFMSALEIGGLLGSLAAGFLSDRAvakhglrlygNPRHGLLLS 306
Cdd:TIGR00895 257 LLyFMLLVGVYFL----TNWLP-KLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRL----------GPRVTALLL 321
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 47550765 307 MMAGMCVSMYLFrttvTAHSSNVwILLLGAAFGFSSYGPIALFGVLANESAPSNYCGTShaiVALMANVGGFLSGL 382
Cdd:TIGR00895 322 LLGAVFAVLVGS----TLFSPTL-LLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATG---VGWAIGIGRLGAII 389
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
14-414 |
5.56e-12 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 66.47 E-value: 5.56e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 14 FLAMFVGYTLYYFNRKTFSFVMPSVMQEIT--LDKDDLGLITSSQSLAYAISKFISGVLSDQMSARWLFSIGLFTVGGIN 91
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSlgLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 92 VIFSQSSSVAVFSGLWFLNGLGQGLGWPPCAKVLRKWFEPSQFGTWWAVLSCSMN----LAGCLGPIIATLMAQSYSWRS 167
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWAlgalLAALVASLLIPLLSGDWGWRI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 168 TLSISGLTCVVTsifcliiirnepsevglpnieagakkgkggssknestfkeFIFSPYLWLMSLGYLVVFGVKTAYTDWG 247
Cdd:cd17316 161 LFLIGALPALLA----------------------------------------LLLRRRTLLLILLWFFISFGYYGLTTFL 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 248 QLFLIQDKGQSALMGSSFMSALEIGGLLGSLAAGFLSDRAvakhglrlygnPRHGLLLSMMAGMCVSMYLFrtTVTAHSS 327
Cdd:cd17316 201 PTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRI-----------GRKKTLVIGLILSGILALPL--FYLLSGS 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 328 NVWILLLGAAFGFSSYGPIALFGVLANESAPSNYCGTSHAIVALMANVGGFLSGLPFGTVAKHHGWNTAFWVaeIACMVT 407
Cdd:cd17316 268 PTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPAL--ILALLA 345
|
....*..
gi 47550765 408 TVGYFLL 414
Cdd:cd17316 346 IVALIVA 352
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
35-413 |
5.99e-12 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 66.58 E-value: 5.99e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 35 MPSVMQEITLDKDDLGLITSSQSLAYAISKFISGVLSDQMSARWLFSIGLFTVGGINVIFSQSSSVAVFSGLWFLNGLGQ 114
Cdd:cd17333 19 GPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGA 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 115 GLGwPPCAKVLRKWFEPSQFGTWWAVLSCSMNLAGCLGPIIATLM-AQSYSWRSTLSISGLTCVVTSIFCLIIIRNEPSE 193
Cdd:cd17333 99 GIL-DTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLlTSELSWSWAYLIIGLIYLLLAILILLTLFPELPS 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 194 VGLPNIEAGAKKgkggsskneSTFKEFIFSPYLWLMSLGYLVVFGVKTAYTDWGQLFLIQDKGQSALMGSSFMSALEIGG 273
Cdd:cd17333 178 ARNPQQSVGAFS---------ASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGI 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 274 LLGSLAAGFLSDRAVAKHGLRLYGnprhgllLSMMAGMCVSMYlfrttvtaHSSNVWILLLGAAFGFSSYGPIALFGVLA 353
Cdd:cd17333 249 TIGRLLGGPISRRIKPHTLLVLSG-------SGALLGLLILLL--------APTLVVGLVATALLGLFMAALFPTILSLG 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 47550765 354 NESAP-SNYCGTSHAIValMANVGGFLSGLPFGTVAKHHGWNTAFWVAEIACMVTTVGYFL 413
Cdd:cd17333 314 ISNLPyAKGKGTSVLLA--AGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAIIFVLALL 372
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
50-400 |
7.43e-12 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 66.42 E-value: 7.43e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 50 GLITSSQSLAYAISKFISGVLSDQMSAR--WLFSIGLFTVGGINVIFSQSSSVAVFSGlwFLNGLGQGLGWPPCAKVLRK 127
Cdd:cd17324 37 GLLVSAYALGYALGALLLGPLSDRIERRrlLLVLLLLFILGNLLAALAPSFALLLLAR--ALAGLAHGGFWAIAAAYAAD 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 128 WFEPSQFGTWWAVLSCSMNLAGCLGPIIATLMAQSYSWRSTLSISGLTCVVTSIFCLIIIRNEPSEvglpnieagakkgK 207
Cdd:cd17324 115 LVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPK-------------K 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 208 GGSSKNESTFKEFIFSPYLWL-MSLGYLVVFGVKTAYTdWGQLFLIQDKGQSALMGSSFMSALEIGGLLGSLAAGFLSDR 286
Cdd:cd17324 182 PGSLGLLSSLLLLLRNPRLRLaYLITFLLFGGFFALYT-YLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADR 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 287 AVAKhglrlygnprhgLLLSMMAGMCVSMYLFrttvTAHSSNVWILLLGAA-FGFSSYGPIALFGVLANESAPSNYcGTS 365
Cdd:cd17324 261 GGRR------------ALLIALLLLAAALLLL----TLLGPSPLLLLVGLVlWGLGFFAAHSALQTRVLRLAPEAR-GLA 323
|
330 340 350
....*....|....*....|....*....|....*
gi 47550765 366 HAIVALMANVGGFLSGLPFGTVAKHHGWNTAFWVA 400
Cdd:cd17324 324 SSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVG 358
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
11-187 |
2.26e-11 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 64.90 E-value: 2.26e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 11 ATIFLAMFVGYTLYYFNRKTFSFVMpsvMQEITLDKDDLGLITSSQSLAYAISKFISGVLSDQMSARWLFSIGLFTVGGI 90
Cdd:cd17325 202 LALFLAIFVLAFAFGALEPFLPLYA---AELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVA 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 91 NVIFSQSSSVAVFSGLWFLNGLGQGLGWPPCAKVLRKWFEPSQFGTWWAVLSCSMNLAGCLGPIIATLMAQSYSWRSTLS 170
Cdd:cd17325 279 LLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFL 358
|
170
....*....|....*..
gi 47550765 171 ISGLTCVVTSIFCLIII 187
Cdd:cd17325 359 AAAALLLLAAVLFLLLR 375
|
|
| MFS_SLC37A3 |
cd17342 |
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ... |
13-162 |
4.66e-11 |
|
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340900 [Multi-domain] Cd Length: 399 Bit Score: 64.26 E-value: 4.66e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 13 IFLAMFVGYTLYYFNRKTFSFVMPSVMQEIT---------------------LDKDD----LGLITSSQSLAYAISKFIS 67
Cdd:cd17342 4 VFILTFFSYALLHATRKTFSNVKPSISAEWTpsnsntsielheetwnanplfPSQDDaalfLGVLDTIFLFSYAIGLFIS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 68 GVLSDQMSARWLFSIGLFTVGGINVIFSQSS------SVAVFSGLWFLNGLGQGLGWPPCAKVLRKWFEPSQFGTWWAVL 141
Cdd:cd17342 84 GWLGDRLNLRLVLAFGMCSSAITVFLFGVLTewlhfyNKYLYCILWVLNGLLQSTGWPCVVAIMGNWFGKSSRGFVLGLW 163
|
170 180
....*....|....*....|.
gi 47550765 142 SCSmnlaGCLGPIIATLMAQS 162
Cdd:cd17342 164 SAC----ASVGNIIGALLASS 180
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
34-414 |
5.57e-11 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 63.74 E-value: 5.57e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 34 VMPSVMQEITLDKDDLGLITSSQSLAYAISKFISGVLSDQMSARWLFSIGLFTVGGINVIFSQSSSVAVFSGLWFLNGLG 113
Cdd:cd17474 21 ILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 114 QGLGWPPCAKVLRKWFEPSQFGTWWAVLSCSMNLAGCLGPIIATLMAqSYSWRSTLSISGLTCVVTSIFCLIIIRNEPse 193
Cdd:cd17474 101 AAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLA-AISWRYPFFLLAALIPVAFLAILFLLPEPK-- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 194 vglpnieagaKKGKGGSSKNESTFKEFIFSPYLWLMSLGYLVVFGVKTAYTDWGQLFLIQDKGQSALMGSSFMSALEIGG 273
Cdd:cd17474 178 ----------EKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 274 LLGSLAAGFLSDRAVakhglrlygnPRHGLLLSMMAGMCVSMYLFrttvtAHSSNVWILLLGAA-FGFSSYGPIALFGVL 352
Cdd:cd17474 248 ALGSLFVGRLLKKRF----------GARRILVIGLLLYALSLLLL-----GFVPSLALLLIAIVlFGLGLGLNLPLLTTL 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 47550765 353 ANESAPSNYCGTSHAIVALMANVGGFLSGLPFGTVAKHHGWNTAFWVAEIACMVTTVGYFLL 414
Cdd:cd17474 313 VTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
30-414 |
1.24e-10 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 62.63 E-value: 1.24e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 30 TFSFVMPSVMQEITLDKDDLGLITSSQSLAYAISKFISGVLSDQMSARWLFSIGLFTVGGINVIFSQS-SSVAVFSGLWF 108
Cdd:cd17353 21 AWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAiSLPLLFLGYGV 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 109 LNGLGQGLGWPPCAKVLRKWFePSQFGTWWAVLSCSMNLAGCLGPIIATLMAQSYSWRSTLSISGLTCVVTSIFCLIIIR 188
Cdd:cd17353 101 LGGIGAGIGYITPVSTAVKWF-PDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLILGIIFLIIIVIGAFLIR 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 189 NEPseVGLPNIEAGAKKGKGGSSKNESTFKEFIFSPYLWLMSLGY-LVVFGVKTAYTDWGQlFLIQDKGQSALMGSSFMS 267
Cdd:cd17353 180 DPP--KGWVPPGVDPLANNAENSPRDYTPREMLRTPTFWLLWLMFfLNATAGLMLIGQAKP-IGQEFAGLDAGIAALAVS 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 268 ALEIGGLLGSLAAGFLSDRAVAKHGLRlygnprhgLLLSMMAGMCVSMYLFRttvtahsSNVWILLLGAAFGFSSYGPI- 346
Cdd:cd17353 257 ILSIFNGGGRPFWGWLSDKIGRKNTLS--------IAFLIQGVAMFLLPFIG-------SVAVLFVLGVALIGFCYGGGf 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 47550765 347 ALFGVLANESAPSNYCGTSHAIVALMANVGGFLSGLPFGTVAKHHGWNTAFWVAEIACMVTTVGYFLL 414
Cdd:cd17353 322 ALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALALALLL 389
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
10-284 |
2.72e-10 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 60.98 E-value: 2.72e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 10 RATIFLAMFVGYTLYYFNRKTFSFVMPSVMQEITLDKDDLGLITSSQSLAYAISKFISGVLSDQMSARWLFSIGLFTVGG 89
Cdd:COG0477 12 RRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 90 INVIFSQSSSVAVFSGLWFLNGLGQGLGWPPCAKVLRKWFEPSQFGTWWAVLSCSMNLAGCLGPIIATLMAQSYSWRSTL 169
Cdd:COG0477 92 ASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIF 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 170 SISGLTCVVTSIFCLIIIRNEPSEVGLPNIEAGAKKGKGGSSKNESTFKEFIFSPYLWLMSLGYLVVFGVKTAYTDWGQL 249
Cdd:COG0477 172 LINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALL 251
|
250 260 270
....*....|....*....|....*....|....*
gi 47550765 250 FLIQDKGQSALMGSSFMSALEIGGLLGSLAAGFLS 284
Cdd:COG0477 252 LLLALLLLAALLLLLLLLLLLALLLALLLLLLLLL 286
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
32-415 |
3.49e-10 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 61.06 E-value: 3.49e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 32 SFVMPSVMQEITLDKDDLGLITSSQSLAYAISKFISGVLSDQMSAR--WLFSIGLFTVGGINVIFSQssSVAVFSGLWFL 109
Cdd:cd17365 19 GFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKrvLLVSVALFGLFTLLTAFAQ--SVLQLALLRFL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 110 NGLGQGLGWPPCAKVLRKWFEPSQFGTWWAVLSCSMNLAGCLGPIIATLMAQSYSWRSTLSISGLTCVVTSIFCLIIIrn 189
Cdd:cd17365 97 TGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPLLRGTL-- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 190 epsevglpnieagakkgkggssknestfkefifspYLWLMS-LGYLVVFGVKTaytdWGQLfLIQDKGQSALMGSSFMSA 268
Cdd:cd17365 175 -----------------------------------LLWVTFfMGLLLVYLLNS----WLPK-LMVEAGYSLSQALTITLL 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 269 LEIGGLLGSLAAGFLSDRavakhglrlyGNPrHGLLLSMMAGMCVSMYLFrttVTAHSSNVWILLLGAAFGFSSYGPIAL 348
Cdd:cd17365 215 LNIGGVIGSLLLGWLADR----------FGP-KRVLALFFALGAVSLALL---GVSPASLVLLYVLVFLAGACVNGAQVG 280
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 47550765 349 FGVLANESAPSNYCGTSHAIVALMANVGGFLSGLPFGT-VAKHHGWNTAFWVAEIACMVTTVGYFLLR 415
Cdd:cd17365 281 LYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLlLAAGLGPESVFLALAIPAALGALAVLLLR 348
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
35-415 |
3.10e-08 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 55.27 E-value: 3.10e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 35 MPSVMQEITLDKDDLGLITSSQSLAYAISKFISGVLSDQMSARWLF--SIGLFTVGGINVIFSQSSSVAVFSGLwfLNGL 112
Cdd:cd17503 19 LPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFltALALFTLGSLLCGLAPNLASLIIFRI--LQGF 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 113 GQGLGWPPCAKVLRKWFEPSQFGTWWAVLSCSMNLAGCLGPIIATLMAQSYSWRSTLSISGLTCVVTSIFCLIIirneps 192
Cdd:cd17503 97 GGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLLAPLL------ 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 193 evglpnieagakkgkggsskNESTFKEFIFSPYLWLMSLGYLVVFGVKTAYTdwgqLFLIQDKGQSALMGSSFMSALEIG 272
Cdd:cd17503 171 --------------------DLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLP----LYLQNVLGYSAFESGLVLAPGGLA 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 273 GLLGSLAAGFLSDRAvakhGLRLygnprhgLLLSMMAGMCVSMYLFrTTVTAHSSNVWILLLGAAFGFS---SYGPI--A 347
Cdd:cd17503 227 SAILSPLVGRLLDKF----GPRL-------LLLAGLLLLALGTLLL-AFLTPDTSLWLIILPLFIRGLGmglVFMPLntL 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 348 LFGVLANESAPSnycGTshAIVALMANVGG--------------------FLSGLPFGTVAKH---HGWNTAFWVAEIAC 404
Cdd:cd17503 295 ALNSLPPEQIGD---AT--ALFNTIRQLGGsigtallatlltnrtqfhhsRLSELLAQQVQKQaliIAFNDAFLVSAILL 369
|
410
....*....|.
gi 47550765 405 MVTTVGYFLLR 415
Cdd:cd17503 370 LVGLLLALFLR 380
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
14-188 |
6.91e-08 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 54.11 E-value: 6.91e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 14 FLAMFVGYTLYYFNRKTFSFVMPSVMQEIT-LDKDDLGLITSSQSLAYAISKFISGVLSDQMSAR--WLFSIGLFTVGGI 90
Cdd:COG2271 182 FWLLALAYFLVYFALYGFLTWLPTYLVEVRgLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAALA 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 91 NVIFSQSSSVAVFSGLWFLNGLGQGLGWPPCAKVLRKWFEPSQFGTWWAVLSCSMNLAGCLGPIIATLMAQSYSWRSTLS 170
Cdd:COG2271 262 LLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFL 341
|
170
....*....|....*...
gi 47550765 171 ISGLTCVVTSIFCLIIIR 188
Cdd:COG2271 342 LLAALALLAALLALLLLR 359
|
|
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
10-183 |
3.72e-07 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 51.93 E-value: 3.72e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 10 RATIFLAMFVGYTLYYFNRKTFSFVMPSVMQEIT--------------------LDKDD----LGLITSSQSLAYAISKF 65
Cdd:cd17344 1 RGFILVLTFLAYACYHLSRKPISIVKSVLHPNCSalipppnivlnnttwcgwapFDGKNgtelLGALDSAFLFAYAIGMF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 66 ISGVLSDQMSARWLFSIGLFTVGGINVIFSQSSSVAVFSgLWF------LNGLGQGLGWPPCAKVLRKWFEPSQFGTWWA 139
Cdd:cd17344 81 FSGHIGERLPLRYFLSFGMLLSGLFTALFGLGYYWNIHS-LWYfvvvqiLAGLFQSTGWPSVVACVGNWFGKGKRGLIMG 159
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 47550765 140 VLSCSMNLAGCLGPIIATLMAqSYSWRSTLSISGLTCVVTSIFC 183
Cdd:cd17344 160 IWNSHTSVGNILGSLIAGIFV-SSAWGLSFIVPGIIIAAMGVLV 202
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
12-381 |
1.06e-06 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 50.71 E-value: 1.06e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 12 TIFLAMFVGYTLYYFNRKTFSFVMPSVMQEIT-LDKDDLGLITSSQSLAYAISKFISGVLSDQMSARWLFSIGLFTVGGI 90
Cdd:cd17327 5 FILPLLCILYFLQYLDKSNISNAAVMGMKEDLkLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 91 NVIFSQSSSVAVFSGLWFLNGLGQGLGWPPCAKVLRKWFEPSQFGTWWAVLSCSMNLAGCLGPIIATLMAQS------YS 164
Cdd:cd17327 85 TLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKIlgvgglAG 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 165 WRSTLSISGLTCVVTSIFCLIIIRNEPSEVGLPNIE--------AGAKKGKGGSSKNE-STFKEFIFSPYLWLMSLGYLV 235
Cdd:cd17327 165 WRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLTEEekelaverLRANQTGKGDQKFKwKQIKEAFKDPRTWLLFLFFFC 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 236 VFGVKTAYTdwGQLFLIQDKGQSALMGSSFMS-ALEIGGLLGSLAAGFLSDRAVAKHglrlygnprhglllSMMAGMCVS 314
Cdd:cd17327 245 SQITNNGIS--NFLPLILKSLGFYSLQTNLLSvPIGALGAVSLLIAALLSDRFKKRG--------------LFAIFACVL 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 47550765 315 MYLFRTTVTAHSSNVWILLLGAAFGFSSYGPIALFGVLANESAPSNYC-GTSHAIVALMANVGGFLSG 381
Cdd:cd17327 309 ALVGSIILLAAPNPPGAYFAAYILGGGSYAGFPILLSWISSNCAGYTKrATVLAIMLIFYNVGNIVAP 376
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
35-415 |
1.10e-06 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 50.25 E-value: 1.10e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 35 MPSVMQEITlDKDDLGLITSSQSLAYAISKFISGVLSDQMSARW--LFSIGLFTVGGINVIFSQSSSVAVFSGLwfLNGL 112
Cdd:cd17502 19 LPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWvlLIAIVIFELGSLLCGLAPNMTMLIVGRA--IQGI 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 113 GQGLGWPPCAKVLRKWFEPSQFGTWWAVLSCSMNLAGCLGPIIATLMAQSYSWRSTLSISgltcVVTSIFCLIIIRNeps 192
Cdd:cd17502 96 GGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYIN----LPIGGLALALLRT--- 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 193 evglpnieagakkgkggssknestfkeFIFSpyLWLMSLGYLVVFGVKTAYTDWGQLFliqdKGQSALMGSSFMSALEIG 272
Cdd:cd17502 169 ---------------------------ILLS--SIFGFLFGGALFGLIYYLPLYFQLV----LGDSATKSGVRLLPLIIG 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 273 GLLGSLAAGFLsdravakhgLRLYGNPRHGLLLSMMagMCVSMYLFRTTVTAHSSNVWILLLGAAFGFSSYGPIALFGVL 352
Cdd:cd17502 216 LVIGSIISGAL---------ISKTGRYKPLIVIGTI--LMSVGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVA 284
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 47550765 353 ANESAPSNYCGTSHAIVALMANVGGFLsglpfgTVAKHHgwntAFWVAEIACMVTTVGYFLLR 415
Cdd:cd17502 285 VQNAVPPADVGVATATNTFFRSLGGTL------GVAITD----VFLVALALAALAFLLSLFLP 337
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
26-415 |
1.67e-06 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 49.92 E-value: 1.67e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 26 FNRKTFSFVMPSVM----QEITLDKDDLGLITSSQSLAYAISKFISGVLSDQMSARWLFSIGLFTVGGINVIFSQSSSVA 101
Cdd:cd17329 10 LNRLGFFMVWPFMAiylhQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPW 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 102 VFSGLWFLNGLGQGLGWPPCAKVLRKWFEPSQFGTWWAVLSCSMNLAGCLGPIIATLMAQsYSWRSTLSISGLTCVVtSI 181
Cdd:cd17329 90 LFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLL-YSFRLLFLAAAVLFLL-AA 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 182 FCLIIIRNEPSEVGLPNIEAGAKKGKGgsskneSTFKEFIFSPYLWLMSLGYLVVFGVKTAYTdwgqLFLIQDKGQSALM 261
Cdd:cd17329 168 LVLLFLLPETRPKRRAAEKTEILRGYK------IVLRDRAFLLFLLASFLISLIYFQLESTLP----VYVVEILGLGESL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 262 GSSFMSaleIGGLLGSLAAGFLSdravakhglRLYGNPRhgLLLSMMAGMCvsMYLFRTTVTAHSSNVWILLLGAAF--- 338
Cdd:cd17329 238 LGLLLA---LNALLIVLLQFPVA---------RLVERFR--LRKILMIGIL--LFAIGFAVLAFANTLAVLILAMIVltl 301
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 47550765 339 GFSSYGPIAlfGVLANESAPSNYCGTSHAIVALMANVGGFLSGLPFGTVAKHHGWNTAFWVAEIACMVTTVGYFLLR 415
Cdd:cd17329 302 GEMLVFPAV--QTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGLQ 376
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
35-377 |
1.67e-06 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 49.86 E-value: 1.67e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 35 MPSVMQEITLDKDDLGLITSSQSLAYAISKFISGVLSDQMSARWLFSIG--LFTVGGINVIFSQSssVAVFSGLWFLNGL 112
Cdd:cd17321 19 LPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGlaLFGLASLLCALAPS--LAFLIAARALQGI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 113 GQGLGWPPCAKVLRKWFEPSQFGTWWAVLSCSMNLAGCLGPIIATLMAQSYSWRSTLSISGLTCVVTsifcliiirneps 192
Cdd:cd17321 97 GAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVA------------- 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 193 evglpnieagakkgkggssknestfkeFIFSPYLWLMSLGYLVVFGVKTAYTDWGQLFLIQDKGQSALMGSSFMSALEIG 272
Cdd:cd17321 164 ---------------------------LLLARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALA 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 273 GLLGSLAAGFLSDRavakHGLRLygnprhgLLLSMMAGMCVSMYLFRTTVTAHSSN---VWILLLGAAFGFSsygpIALF 349
Cdd:cd17321 217 MLVAAPLAGRLADR----FGPRL-------VLVAGLLLTAVGLLLLALLGADSSVWlllPGLVLLGLGLGLF----ATPL 281
|
330 340
....*....|....*....|....*...
gi 47550765 350 GVLANESAPSNYCGTSHAIVALMANVGG 377
Cdd:cd17321 282 TNAALSSVPKEKAGAASGILNTARQLGG 309
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
13-415 |
1.92e-06 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 49.51 E-value: 1.92e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 13 IFLAMFVGYTLYYFnrktFSFVMPSVMQEITLDKDDLGLITSSQSLAYAISKFISGVLSDQMSARWLFSIGL--FTVGGI 90
Cdd:cd17489 1 ILLANFFFFLSFYL----LLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLliFALATL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 91 NVIFsqSSSVAVFSGLWFLNGLGQGLGWPPCAKVLRKWFEPSQFGTWWAVLSCSMNLAGCLGPIIATLMAQSYSWRSTLS 170
Cdd:cd17489 77 LYLL--ATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFI 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 171 ISGLTCVVTSIFCLIIIRNEPSevglpnieagakkgKGGSSKNESTFKEFIFSPYLWLMSLGYLVV---FGVKTAYTDwg 247
Cdd:cd17489 155 VAAVLALLALLLVFLVKDPPPV--------------AAEEAEAGTRAFRRLVEKKVLPPALILFLAsiaYGAISTFLP-- 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 248 qLFLIQdkgQSALMGSSFMSALEIGGLLGSLAAGFLSDravakhglrlygnpRHGLLLSMMAGM---CVSMYLFrttvtA 324
Cdd:cd17489 219 -LYAAE---RGISNAGLFFTVYAIALLLSRPFSGKLSD--------------RKGPKTVIIPGLlllALGLLLL-----S 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 325 HSSNVWILLLGAAF---GFSSYGPIalFGVLANESAPSNYCGTSHAIVALMANVGGFLSGLPFGTVAKHHGWNTAFWVAE 401
Cdd:cd17489 276 FAGSPWMLLLAAVLyglGFGLLFPA--LQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAA 353
|
410
....*....|....
gi 47550765 402 IACMVTTVGYFLLR 415
Cdd:cd17489 354 VVVLLALVLYIFLL 367
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
14-409 |
3.64e-06 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 48.79 E-value: 3.64e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 14 FLAMFVGYTLYYfnrkTFSFVMPSVMQEITLDKDDLGLITSSQSLAYAISKFISGVLSDQMSARWLFSIGLfTVGGINVI 93
Cdd:cd17341 5 WLSFFLGFMVWF----LFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASL-LLLLIPLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 94 FSQS--SSVAVFSGLWFLNGLGqGLGWPPCAKVLRKWFEPSQFGTWWAVLSCSMN----LAGCLGPIIAT---LMAQSYS 164
Cdd:cd17341 80 ALALavSSYWGLLVLGFLLGFA-GANFASGQPWASFWFPKEKIGGAAGGIAGAGNmgvaVSQLLAPLIAGaivFDGGFVG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 165 WRSTLSISGLTCVVTSIFCLIIIRNEPsevglpnieagakKGKGGSSKNESTFKEFIFSPYLWLMSLGYLVVFGVKTAYT 244
Cdd:cd17341 159 WRNAFFVPGILLAIAAVLVLLFGDDLP-------------TGKASALEFLKVQLAVLKNYRTWILSLLYGVTFGSFVGFS 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 245 DWGQLFLIQDKGQSALMGSSFMSaleIGGLLGSL---AAGFLSDRavakHGLRlygnprhGLLLSMMAGMCVSMYLFRTT 321
Cdd:cd17341 226 NVLPTYFKTRFGLPLVTAGILAA---LFPLAGALarpAGGWLSDR----FGGR-------RRLWWLFIVMTIGAALLSLS 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 322 VTAHSSNVWILLLGAAFGFSSYGPI--ALFGVLANESapSNYCGTSHAIVALMANVGGFLSGLPFGTVAKHHG-WNTAFW 398
Cdd:cd17341 292 LPTSGTNLVLFLALFVALGLGAGAGngSVFRMVPFIF--RRELGAVTGLVGAIGGLGGFFLPLLFGSSALMTGsGVGAFS 369
|
410
....*....|....
gi 47550765 399 ---VAEIACMVTTV 409
Cdd:cd17341 370 lfgVLAVACTLLVW 383
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
13-194 |
6.62e-06 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 47.95 E-value: 6.62e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 13 IFLAMFVGYTLYYfnrkTFSFVMPSVMQEIT-LDKDDLGLITSSQSLAYAISKFISGVLSDQMSARWLFSIGLFTVGGIN 91
Cdd:COG2223 210 LSLLYFGTFGSFI----GFSSWLPPYLVDQFgLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGL 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 92 VIFSQSS-SVAVFSGLWFLNGLGQGLGWPPCAKVLRKWFEPSQFGTWWAVLSCSMNLAGCLGPIIATLMAQSY-SWRSTL 169
Cdd:COG2223 286 LLLALALgSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATgSYTAAF 365
|
170 180
....*....|....*....|....*
gi 47550765 170 SISGLTCVVTSIFCLIIIRNEPSEV 194
Cdd:COG2223 366 LVFAVLALVALVLTLLLYRRPRRAA 390
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
15-188 |
7.39e-06 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 47.93 E-value: 7.39e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 15 LAMFVGYTLYYFNRKTFSFVMPSVMQEITLDKDDLGLITSSQSLAYAISKFISGVLSDQMSARWLFSIGLFTVGGINVI- 93
Cdd:cd17380 2 ILLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLt 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 94 -FSQSSSVAVFSGLWFLNGLGQGLGWPPCAKVLRKWFEPSQFGTWWAVLSCSMNLAGCLGPIIATLMAQSYSWRSTLSIS 172
Cdd:cd17380 82 pLLAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFF 161
|
170
....*....|....*.
gi 47550765 173 GLTCVVTSIFCLIIIR 188
Cdd:cd17380 162 GLLGLLWALVWLIYLP 177
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
58-187 |
8.46e-06 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 45.33 E-value: 8.46e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 58 LAYAISKFISGVLSDQMSARW------LFSIGLFTVGgiNVIFSQSSSVAVFSGLWFLNGLGQGLGWPPCAKVLRKWFEP 131
Cdd:TIGR00880 5 AGYALGQLIYSPLSGLLTDRFgrkpvlLVGLFIFVLS--TAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPP 82
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 47550765 132 SQFGTWWAVLSCSMNLAGCLGPIIATLMAQSYSWRSTLSISGLTCVVTSIFCLIII 187
Cdd:TIGR00880 83 EERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLL 138
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
50-415 |
1.58e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 46.80 E-value: 1.58e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 50 GLITSSQSLAYAISKFISGVLSDQMSARWLFSIGL--FTVGGINVIFSQSSSVAVFSGlwFLNGLGQGLGWPPCAKVLRK 127
Cdd:cd17473 38 PLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLllYGIGGVAGLFLDSLYALLASR--ALLGIGVAGIMTLATALIGD 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 128 WFEPSQFGTWWAVLSCSMNLAGCLGPIIATLMAqSYSWRSTLSI--SGLTCVVTSIFCliiirnepsevgLPNIEAGAKK 205
Cdd:cd17473 116 YFEGEERAKMLGLQSAAMSLGGVVFLLLGGALA-EIGWRAPFLVylLALPVLILVLLF------------LPEPARKSKS 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 206 GKGGSSKNESTFKEFIFSPYLWLMSLGYLVVFGVKTAYTdwgqlFLIQDKG-QSALMGSSFMSALEIGGLLGSLAAGFLS 284
Cdd:cd17473 183 AASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLP-----FLLQERGgGSAALIGLALAIASLAGAIGALLFGRLK 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 285 DRAvakhglrlygnPRHGLLLSMMAGMCVSMYLFrttvtAHSSNVWILLLGAA---FGFSSYGPIALfgVLANESAPSNY 361
Cdd:cd17473 258 RRL-----------GKRRLLAIGFALMALGFLLL-----ALASGLWVVLLGAIlagLGFGLLLPTLN--SWAMSLVPPEL 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 47550765 362 CGTSHAIVALMANVGGFLSGLPFGTVAK-HHGWNTAFWVAEIACMVTTVGYFLLR 415
Cdd:cd17473 320 RGRAMGIVTSAFFLGQFLSPLVLGPLVNlTGGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
29-415 |
1.79e-05 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 46.39 E-value: 1.79e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 29 KTFSFVMPSVMQEITLDKDDLGLITSSQSLAYAISKFISGVLSDQMSARWLFSIG-LFTVGGINVIFSQSSSVAVFSGLW 107
Cdd:cd17352 20 NSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGgLLAALGLLLSSFATSLWQLYLTYG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 108 FLNGLGQGLGWPPCAKVLRKWFEpSQFGTWWAVLSCSMNLAGCLGPIIATLMAQSYSWRSTLSISGLTCVVTSIFCLIII 187
Cdd:cd17352 100 VLGGLGLGLIYSPAIVIVGQYFE-KKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALLILGGLCLNLCVCGLLLR 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 188 rnepsevglpnieagakkgkggssknesTFKEFIFSPYLW---LMSLGYLVVFGVKTAYTdwgqlfliQDKGQSALMGSS 264
Cdd:cd17352 179 ----------------------------LLKDPTFVLLALgvsFAMLGFFVPFVYLPSYA--------KSLGIDESDAAF 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 265 FMSALEIGGLLGSLAAGFLSDRavakhglRLYGNPRHGLLLSMMAGMCVSMYLFRTTVTAhssnvwILLLGAAFGFSSYG 344
Cdd:cd17352 223 LLSIIGISDIVGRILLGLLADK-------PRIGRLYLYIFTLLILGLSLLAFPLATTYVG------LIVFSVLFGFCSGS 289
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 47550765 345 PIALFGVLANESAPSNYCGTSHAIVALMANVGGFLSGLPFGTVA-KHHGWNTAFWVAEIACMVTTVGYFLLR 415
Cdd:cd17352 290 YSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRdYTGDYDAAFYFCGACLLLSGVLLFLLP 361
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
15-185 |
4.74e-05 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 45.70 E-value: 4.74e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 15 LAMFVGYTLYYFNRKTFSFVMPSVMQEItLDKDDLGLITSSQSLAYAISKFISGVLSDQMSARWLFSIG--LFTVGGInv 92
Cdd:cd06179 1 AALCLAYFAQLFGVTLPAAVLPFIVADL-GPSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGnlLGVVGSI-- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 93 IFSQSSSVAVFSGLWFLNGLG---QGLGWPPCAKVLrkwfEPSQFGTWWAVLSCSMNLAGCLGPIIATLMAQSY--SWRS 167
Cdd:cd06179 78 VAGTAKSVNMLIGGQALIGIGagtQGLGAAVASELV----PNKYRGLVQGVVNLVASPGSALGPLIAGALVEANaaGWRW 153
|
170
....*....|....*...
gi 47550765 168 TLSISGLTCVVTSIFCLI 185
Cdd:cd06179 154 IFYINAIFNALALILLFF 171
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
58-344 |
4.95e-05 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 45.26 E-value: 4.95e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 58 LAYAISKFISGVLSDQMSARWLFSIGLFTVGGINVIFSQSSSVAVFSGLWFLNGLGQGLGWPPCAKVLRKWFEPSQFGTW 137
Cdd:cd17323 45 LGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKA 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 138 WAVLSCSMNLAGCLGPIIATLMAQSYSWRST---LSISGLTCVVTSIFCLIIIrnepSEVGLPNIeagakkgkggsskne 214
Cdd:cd17323 125 MGVYSLGPLLGPALGPIIGGFITQSLGWRWIfwfLAIISGFCLILIFLFLPIV----LLLGLYVG--------------- 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 215 stfkeFIFSpYLWLMSLGYLVVFGVKTAYTDWGQlfliqdkgqsalmGSSFMSALeIGGLLGSLAAGFLSDRAVAKHGLR 294
Cdd:cd17323 186 -----LVYA-ILYLFLTAFPYVFGEVYGFSPGEV-------------GLMYLPIG-IGALIGSIIGGRLSDYYYRRLKKK 245
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 47550765 295 LYGNPR-HGLLLSMMAG---MCVSMYLFRTTVTAHSSNVWILLLGAAFGFSSYG 344
Cdd:cd17323 246 NGGKPEpEARLPPAFIGaflFPIGLFIFGWTIYPHIHWIVPIIGSAFFGFGLML 299
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
14-161 |
5.08e-05 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 45.26 E-value: 5.08e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 14 FLAMFVGYTLYYFNRKTFSFVMPSVMQEIT-LDKDDLGLITSSQSLAYAISKFISGVLSDQMSARWLFSIGLFTVGGINV 92
Cdd:cd17503 180 FTLGLLLSFLLGLGLFGAMFLLPLYLQNVLgYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTL 259
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 47550765 93 IFSQ---SSSVAVFSGLWFLNGLGQGLGWPPCAKVLRKWFEPSQFGTWWAVLSCSMNLAGCLG-PIIATLMAQ 161
Cdd:cd17503 260 LLAFltpDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGtALLATLLTN 332
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
58-353 |
5.84e-05 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 44.87 E-value: 5.84e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 58 LAYAISKFISGVLSDQMSAR--WLFSIGLFTVGGINVIFSQSSSVAVFsgLWFLNGLGQGLGWPPCAKVLRKWFEPSQFG 135
Cdd:cd17320 45 LGFALGQLLYGPLSDRFGRRpvLLAGLLLFILASLLCALASSIEQLLI--ARFLQGLGAAAGSVVARAIVRDLYSGAELA 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 136 TWWAVLSCSMNLAGCLGPIIATLMAQSYSWRS---TLSISGLTCVVTSIFCLiiirNEPSEVglpnieagaKKGKGGSSK 212
Cdd:cd17320 123 KIFSLLMMILAIAPALAPLLGGLLLLFFGWRAifvFLALLGLLLLLLVLLFL----PETLPE---------EKRKPLLSS 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 213 NESTFKEFIFSPYLWLMSLGYLVVFGVKTAYTDWGQLFLIQDKGQSALMGSSFMSALEIGGLLGSLAAGFLSDRAVAKHG 292
Cdd:cd17320 190 LLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRL 269
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 47550765 293 LRLygnprhGLLLSMMAGMCVSMYLFRTTVTAHSsnVWILLLGAAFGFSSYGPIALFGVLA 353
Cdd:cd17320 270 LRL------GLLLLLAAALVLLLAALLGGLSLWP--LVAPLFLIFFGFGLIFPNATSLALE 322
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
11-185 |
1.09e-04 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 44.10 E-value: 1.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 11 ATIFLAMFVGYTLYYfnrkTFSFVMPSVMQEITLDKDDL-GLITSSQSLAYAISKFISGVLSDQMSARWLFSIGLFTVGG 89
Cdd:cd17473 200 LPIYFLAFLAMLLFY----VIPIQLPFLLQERGGGSAALiGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMAL 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 90 INVIFSQSSSVAVFSGLWFLNGLGQGLGWPPCAKVLRKWFEPSQFGTWWAVLSCSMNLAGCLGP-IIATLMAQSYSWRST 168
Cdd:cd17473 276 GFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPlVLGPLVNLTGGLSGA 355
|
170
....*....|....*..
gi 47550765 169 LSISGLTCVVTSIFCLI 185
Cdd:cd17473 356 FLILGVLALVLAIVLLL 372
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
49-400 |
1.27e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 44.07 E-value: 1.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 49 LGLITS-SQSLAYaISKFISGVLSDQMSARWLFSIGLFTVGGINVI-FSQSSSVAVFSGLWFLNGLGQGLGWPP------ 120
Cdd:cd17370 36 VGLIEGlAEALGS-LLRLFSGYLSDRTGKRKPLVILGYGLSALAKPlLALAGSWQLVLLLRILERLGKGIRTPPrdalla 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 121 --CAKVLRKWfepsQFGtwwavLSCSMNLAGC-LGPIIATLM--AQSYSWRSTLSISGLTCVVtSIFCLIIIRNEPsevg 195
Cdd:cd17370 115 daTPPSGRGK----AFG-----LHRALDTLGAvLGPLLAALLlyLLGGNYRTIFLLAAIPALL-ALLILLFVVKEY---- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 196 lpnieagakKGKGGSSKNESTFKEFIFSPYLWLMSlgyLVVFGVKTAYTDWGQLFL-IQDKGQSALMGSSFMSALEIGGL 274
Cdd:cd17370 181 ---------PRPPKLRKKSKKTSLKKLPKAFWLYL---LAVALFALGNFSFAFLILrAQELGLSAALIPLLYALFNLVYA 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 275 LGSLAAGFLSDRavakhglrlygNPRHGLLLSMMAGMCVSMYLFrttvtAHSSNVWILLLGAAFGFSSYGPI-ALFGVLA 353
Cdd:cd17370 249 LAAYPAGRLSDR-----------IGRKKLLILGYLSLALAYLGF-----ALGSSLWLLLLGFILWGLYMGAQeSIERAAV 312
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 47550765 354 NESAPSNYCGTSHAIVALMANVGGFLSGLPFGTVAKHHGWNTAFWVA 400
Cdd:cd17370 313 ADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFS 359
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
250-409 |
3.91e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 42.27 E-value: 3.91e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 250 FLIQDKGQSALMGSSFMSALEIGGLLGSLAAGFLSDRAvakhglrlygnPRHGLLLSMMAGMCVSMYLFrttvtAHSSNV 329
Cdd:COG2814 35 LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRF-----------GRRRVLLLGLLLFALGSLLC-----ALAPSL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 330 WILLLGAAF-GFSSYGPIALFGVLANESAPSNYCGTSHAIVALMANVGGFLSGLPFGTVAKHHGWNTAFWVAEIACMVTT 408
Cdd:COG2814 99 WLLLAARFLqGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLAL 178
|
.
gi 47550765 409 V 409
Cdd:COG2814 179 L 179
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
229-428 |
4.06e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 42.41 E-value: 4.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 229 MSLGYLVVFGVKTAYTDWGQLFLIQDKGQSALMGSSFMSALEIGGLLGSLAAGFLSDRavakhglrlYGNPRhgLLLSMM 308
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDR---------FGRRR--VLLIGL 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 309 AGMCVSMYLFrttvTAHSSNVWILLLGAAFGFSSYGPIALFGVLANESAPSNYCGTSHAIVALMANVGGFLSGLPFGTVA 388
Cdd:pfam07690 70 LLFALGLLLL----LFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLA 145
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 47550765 389 KHHGWNTAFWVAEIACMVTTVGYFLLRNIRTKMGSIPKKA 428
Cdd:pfam07690 146 SLFGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEE 185
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
47-406 |
5.03e-04 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 42.04 E-value: 5.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 47 DDLGLITSSQSLAYAISKFISGVLSDQMSARWLFSIGLFTVGGINVIFSQSSSVavfSGLW-----FLNGLGQGLGWPPC 121
Cdd:TIGR00894 76 ALQGLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGG---GIALvvfcrVIQGLAQGSVSPAT 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 122 AKVLRKWFEPSQFGTWwavlsCSMNLAG-CLGPIIATLMA-----QSYSWRSTLSISGLTCVVTSIFCLIIIRNEPSEVg 195
Cdd:TIGR00894 153 HKIIVKWAPPKERSRL-----LGMSTSGfQLGTFIFLPISgwlceSWGGWPMIFYVFGIVGCAWSLLWFVFPADDPSIH- 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 196 lPNIEAGAKK-------GKGGSSKNESTFKEFIFSPYLWLMSLGylvVFGVKTAYTDWGQLF--LIQDKGQSALMGSSFM 266
Cdd:TIGR00894 227 -PCISKFEKKyinsslqGQKGSTRQSLPIKAIPKSLPVWAIWFA---IFGHFWLYTILPTYLptFISWVLRVSGKENGLL 302
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 267 SALEI------GGLLGSLAAGFLSDRAVAKHGLRLYGNPRhGLLLSMMAGMCVSMylfrtTVTAHSSNVWILLLGAAFgf 340
Cdd:TIGR00894 303 SSLPYlfawlcSIFAGYLADFLKSSKTLSLTAARKIFNGI-GGLGPGIFAYALPY-----LSAAFYLTIIILTLANAV-- 374
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 47550765 341 sSYGPIALFGVLANESAPSnYCGTSHAIVALMANVGGFLSGLPFGTVAKHHGWNTAFWVAEIACMV 406
Cdd:TIGR00894 375 -SSGPLAGVLINSLDLAPR-FLGFIKGITGLPGFIGGLIASTLAGNILSQDSKNVWLIVFLIMAFV 438
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
258-418 |
7.78e-04 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 41.41 E-value: 7.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 258 SALMGSSFMSALEIGGLLGSLAAGFLSDRAVAKHGLRLYGNPrhglllsMMAGMCVSmylfrttvtAHSSNVWIL----- 332
Cdd:cd17315 32 STSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVL-------YVIGALLS---------ALAPNVWVLivgrf 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 333 LLGAAFGFSSygpiALFGVLANESAPSNYCGTSHAIVALMANVGGFLS---GLPFGTVAKhHGWNTAFWVAEIACMVTTV 409
Cdd:cd17315 96 LLGLGVGLAS----VLVPLYISEIAPAKIRGALGTLNQLMITFGILLAyllGLALSLSPP-GWWRLMFALAAVPALLQLL 170
|
....*....
gi 47550765 410 GYFLLRNIR 418
Cdd:cd17315 171 LMFFLPESR 179
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
8-402 |
1.11e-03 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 40.86 E-value: 1.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 8 YYRATIFLAMFVGYTLyyfnrkTFSFVMPSVMQEITLDKDDLGLITSSQSLAYAISKFISGVLSDQMSARWLFSIGLFTV 87
Cdd:cd17314 5 LYVSFLLSAMSTGFIL------SWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 88 -GGINVIFSQSSSVAVFSGLWFLNGLGQGLGWPPCAKVLRKWFePSQFGTWWAVLSCSMNLAGCLGPIIATLMAQSYSWR 166
Cdd:cd17314 79 lAGYTYLSYVFNSFPLSYACFVFIGAGTGILYGSAVLVTTQYF-PDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 167 STLSISGLtcvvtsifcLIIIRNEPSEVGLPNIEAGAKKGKGGSSKNESTFKEFIFSPYLWLMSLGYLVVF--GVKTAYT 244
Cdd:cd17314 158 LVYTILGI---------LAAIVLSVVSLLGFKEPPDNQARLHVQKKKTQTMGEIFRDKVFWILFIAIFLVLigGFLFIAN 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 245 DWGQLFLIQDKGQSALMGssFMSALEIGGLLGSLAAGFLSDRAVAkhglrlygnpRHGLLLSMMAGMCVSMYLFRTTVTa 324
Cdd:cd17314 229 MASLVRSLQLDAPSFVTK--LMSIYGLFNAFGRLLWGIVADFFGG----------RLSTLSILLTILGLGLCAFLFLLK- 295
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 47550765 325 hSSNVWILLLGAAFGFSSYGPIALFGVLANESAPSNYCGTSHAIVALMANVGGFLSGLPFGTV-AKHHGWNTAFWVAEI 402
Cdd:cd17314 296 -MTPVGLVLTGSLLGFSYGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFyDRTPSYISAVYIYAV 373
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
256-418 |
1.40e-03 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 40.61 E-value: 1.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 256 GQSALMGSSFMsaleIGGLLGSLAAGFLSDRAvakhglrlygnPRHGLLLSMMAGMCVSmylfrTTVTAHSSNVWILLLG 335
Cdd:cd17324 34 AQAGLLVSAYA----LGYALGALLLGPLSDRI-----------ERRRLLLVLLLLFILG-----NLLAALAPSFALLLLA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 336 AAF-GFSSYGPIALFGVLANESAPSNYCGTSHAIVaLMANVGGFLSGLPFGT-VAKHHGWNTAFWVAEIACMVTTVG-YF 412
Cdd:cd17324 94 RALaGLAHGGFWAIAAAYAADLVPPEKRGRAIGLV-FSGLTLGLVLGRPLGGlLGQLLGWRAAFLAIAVLALLAALLlWR 172
|
....*.
gi 47550765 413 LLRNIR 418
Cdd:cd17324 173 LLPSLP 178
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
36-364 |
1.78e-03 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 40.33 E-value: 1.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 36 PSVMQEITLDKDDLGLITSSQSLAYAISKFISGVLSDQMSAR--WLFSIGLFTvgginvIFSQSSS-VAVFSGLW---FL 109
Cdd:PRK11551 39 PRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKriLIVSVALFG------LFSLATAqAWDFPSLLvarLL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 110 NGLGQGLGWPPCAKVLRKWFEPSQFGTWWAVLSCSMNLAGCLGPIIATLMAQSYSWRSTLSISGLTCVVTsIFCLIIIrn 189
Cdd:PRK11551 113 TGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFYVGGVGPLLL-VPLLMRW-- 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 190 epsevgLPniEAGAKKGKGGSSKNESTFKEFIFSP-------YLWLMSLGYLVVFgvktaY--TDWGQLFLIqDKGQSAL 260
Cdd:PRK11551 190 ------LP--ESRAFAQAAGAGKQRAPVLRALFGEgratatlLLWISYFFTLIVL-----YflLNWLPSLLV-GQGLSRS 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 261 MGSSFMSALEIGGLLGSLAAGFLSDRavakhglrlyGNPRHGLLLsMMAGMCVSMylfrTTVTAHSSNVWILLLGAAFG- 339
Cdd:PRK11551 256 QAGLVQIAFNIGGALGSLLIGALMDR----------LRPRRVVLL-IYAGILASL----AALAAAPSFAGMLLAGFAAGl 320
|
330 340
....*....|....*....|....*
gi 47550765 340 FSSYGPIALFGvLANESAPSNYCGT 364
Cdd:PRK11551 321 FVVGGQSVLYA-LAPLFYPTQVRGT 344
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
14-166 |
3.59e-03 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 39.67 E-value: 3.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 14 FLAMFVGYTLYYFNRKTFSFVMPSVMQEITLDKDDLGLITSSQSLAYAISKFISGVLSDQMSARWLFSIGLFTVGGINVI 93
Cdd:TIGR00711 4 TIVLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLL 83
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 47550765 94 FSQSSSVAVFSGLWFLNGLGQGLGWPPCAKVLRKWFEPSQFGTWWAVLSCSMNLAGCLGPIIATLMAQSYSWR 166
Cdd:TIGR00711 84 CGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWR 156
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
14-347 |
5.83e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 38.73 E-value: 5.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 14 FLAMFVGYTLYYFnrktfsFVMPSVMQEITLDKDDLGLITSSQSLAYAISKFISGVLSDQMSARW--------------- 78
Cdd:COG2211 19 DLGLNLAFGLLSA------YLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWgrrrpwiligaipla 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 79 LFSIGLFTVGGinviFSQSSSVAVFSGLWFLNGLGQGLGWPPC----AKVLRKWFEPSQFGTWWAVLScsmNLAGCLGPI 154
Cdd:COG2211 93 LSFVLLFTAPD----LSPTGKLIYALVTYLLLGLAYTLVNIPYsalgAELTPDYEERTRLSSWRFAFA---GLGGLLASV 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 155 IATLMAQSYS------WRSTLSISGLTCVVTSIFCLIIIRnepsevglpniEAGAKKGKGGSSKneSTFKEFIFSPYLWL 228
Cdd:COG2211 166 LPPPLVAAFGgdaalgYRLTALIFAVLGLLAFLLTFFGTK-----------ERPVPEEEKVSLK--ESLKALLKNRPFLL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 229 MSLGYLVVFGVKTAYTDWGQLFLIQDKGQSALMGSSFMSALEIGGLLGSLAAGFLSDRavakhglrlYGnpRHGLLLSMM 308
Cdd:COG2211 233 LLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKR---------FG--KKKAFIIGL 301
|
330 340 350
....*....|....*....|....*....|....*....
gi 47550765 309 AGMCVSMYLFRTTVTAHSSNVWILLLGAAFGFSSYGPIA 347
Cdd:COG2211 302 LLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLP 340
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
13-186 |
8.57e-03 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 38.30 E-value: 8.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 13 IFLAMFVGYTLYYFNRKTFSFVMPSVMQEITLDKDDLGLITSSQSLAYAISKFISGVLSDQ--MSARWLFSIGLFTVGGI 90
Cdd:cd17352 184 TFVLLALGVSFAMLGFFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKprIGRLYLYIFTLLILGLS 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550765 91 NVIFSQSSSVAVFSGLWFLNGLGQGLGWPPCAKVLRKWFEPSQFGTWWAVLSCSMNLAGCLGPIIATLMA-QSYSWRSTL 169
Cdd:cd17352 264 LLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRdYTGDYDAAF 343
|
170
....*....|....*..
gi 47550765 170 SISGLTCVVTSIFCLII 186
Cdd:cd17352 344 YFCGACLLLSGVLLFLL 360
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
45-182 |
9.39e-03 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 37.98 E-value: 9.39e-03
10 20 30 40 50 60 70 80
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gi 47550765 45 DKDDLGLITSSQSLAYAISKFISGVLSDQMSARWLFSIGLFtvggINVIFSQSSSVAVFSGLW------FLNGLGQGLGW 118
Cdd:cd17318 54 SEKTQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSIL----ITALLTLLTPLAARGGYGalivlrILQGLAQGVTF 129
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90 100 110 120 130 140
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gi 47550765 119 PPCAKVLRKWFEPSQFGtwwaVLSCSMNLAGCLGPIIAT----LMAQSYSWRSTLSISGLTCVVTSIF 182
Cdd:cd17318 130 PAMHALWAKWAPPLERS----RLTSIAYSGSQFGTVIAMplsgFLCESLGWPSIFYIFGGLGLLWCLL 193
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