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Conserved domains on  [gi|489914829|ref|WP_003818232|]
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MULTISPECIES: SET domain-containing protein [Bordetella]

Protein Classification

SET domain-containing protein( domain architecture ID 11459262)

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain-containing protein may function as a protein-lysine N-methyltransferase, catalyzing the S-adenosyl-L-methionine (SAM)-dependent methylation at specific lysine residues of target proteins such as histones

CATH:  2.170.270.10
EC:  2.1.1.-
Gene Ontology:  GO:0005515|GO:0008168|GO:1904047
PubMed:  12372294|17013555|16086857

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
5-148 3.11e-61

SET domain-containing protein (function unknown) [General function prediction only];


:

Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 185.55  E-value: 3.11e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829   5 IKPWHSVRRSRLHGNGVFATRKIPAGTRIIEYGGKRISAEEADRRHPTnpDDPFHTFFFSLSSGRVIDGGDEGNDARWIN 84
Cdd:COG2940    4 LHPRIEVRPSPIHGRGVFATRDIPKGTLIGEYPGEVITWAEAERREPH--KEPLHTYLFELDDDGVIDGALGGNPARFIN 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489914829  85 HSCDPNCEAQEGRHgkRVYIVALRDIARGEELFYDYGLVLDgritrklKEGYRCLCGTtpCRGT 148
Cdd:COG2940   82 HSCDPNCEADEEDG--RIFIVALRDIAAGEELTYDYGLDYD-------EEEYPCRCPN--CRGT 134
 
Name Accession Description Interval E-value
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
5-148 3.11e-61

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 185.55  E-value: 3.11e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829   5 IKPWHSVRRSRLHGNGVFATRKIPAGTRIIEYGGKRISAEEADRRHPTnpDDPFHTFFFSLSSGRVIDGGDEGNDARWIN 84
Cdd:COG2940    4 LHPRIEVRPSPIHGRGVFATRDIPKGTLIGEYPGEVITWAEAERREPH--KEPLHTYLFELDDDGVIDGALGGNPARFIN 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489914829  85 HSCDPNCEAQEGRHgkRVYIVALRDIARGEELFYDYGLVLDgritrklKEGYRCLCGTtpCRGT 148
Cdd:COG2940   82 HSCDPNCEADEEDG--RIFIVALRDIAAGEELTYDYGLDYD-------EEEYPCRCPN--CRGT 134
SET_ASH1L cd19174
SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ...
 18-147 1.29e-35

SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ASH1L (EC 2.1.1.43; also termed absent small and homeotic disks protein 1 homolog, KMT2H, or lysine N-methyltransferase 2H) acts as histone-lysine N-methyltransferase that specifically methylates 'Lys-36' of histone H3 (H3K36me). It plays important roles in development; heterozygous mutation of ASH1L is associated with severe intellectual disability (ID) and multiple congenital anomaly (MCA).


Pssm-ID: 380951 [Multi-domain]  Cd Length: 141  Bit Score: 120.86  E-value: 1.29e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  18 GNGVFATRKIPAGTRIIEYGGKRISAEEADRRHPTNPDDPFHTFFFSLSSGRVIDGGDEGNDARWINHSCDPNCEAQE-- 95
Cdd:cd19174   11 GWGVRTKEPIKAGQFIIEYVGEVVSEQEFRRRMIEQYHNHSHHYCLNLDSGMVIDGYRMGNEARFVNHSCDPNCEMQKws 90

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 489914829  96 --GRHgkRVYIVALRDIARGEELFYDYGLVLDGritrkLKEGYRCLCGTTPCRG 147
Cdd:cd19174   91 vnGVY--RIGLFALKDIPAGEELTYDYNFHSFN-----VEKQQPCKCGSPNCRG 137
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 11-126 1.20e-34

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 117.82  E-value: 1.20e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829    11 VRRSRLHGNGVFATRKIPAGTRIIEYGGKRISAEEADRRhPTNPDD--PFHTFFFSLSSGRVIDGGDEGNDARWINHSCD 88
Cdd:smart00317   5 VFKSPGKGWGVRATEDIPKGEFIGEYVGEIITSEEAEER-PKAYDTdgAKAFYLFDIDSDLCIDARRKGNLARFINHSCE 83

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 489914829    89 PNCEAQ--EGRHGKRVYIVALRDIARGEELFYDYGLVLDG 126
Cdd:smart00317  84 PNCELLfvEVNGDDRIVIFALRDIKPGEELTIDYGSDYAN 123
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 18-121 1.10e-32

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 112.62  E-value: 1.10e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829   18 GNGVFATRKIPAGTRIIEY-GGKRISAEEADRRHPTNPD----DPFHTFFFSLS--SGRVIDGGDE--GNDARWINHSCD 88
Cdd:pfam00856   1 GRGLFATEDIPKGEFIGEYvEVLLITKEEADKRELLYYDklelRLWGPYLFTLDedSEYCIDARALyyGNWARFINHSCD 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 489914829   89 PNCEA--QEGRHGKRVYIVALRDIARGEELFYDYG 121
Cdd:pfam00856  81 PNCEVrvVYVNGGPRIVIFALRDIKPGEELTIDYG 115
 
Name Accession Description Interval E-value
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
5-148 3.11e-61

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 185.55  E-value: 3.11e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829   5 IKPWHSVRRSRLHGNGVFATRKIPAGTRIIEYGGKRISAEEADRRHPTnpDDPFHTFFFSLSSGRVIDGGDEGNDARWIN 84
Cdd:COG2940    4 LHPRIEVRPSPIHGRGVFATRDIPKGTLIGEYPGEVITWAEAERREPH--KEPLHTYLFELDDDGVIDGALGGNPARFIN 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489914829  85 HSCDPNCEAQEGRHgkRVYIVALRDIARGEELFYDYGLVLDgritrklKEGYRCLCGTtpCRGT 148
Cdd:COG2940   82 HSCDPNCEADEEDG--RIFIVALRDIAAGEELTYDYGLDYD-------EEEYPCRCPN--CRGT 134
SET_ASH1L cd19174
SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ...
 18-147 1.29e-35

SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ASH1L (EC 2.1.1.43; also termed absent small and homeotic disks protein 1 homolog, KMT2H, or lysine N-methyltransferase 2H) acts as histone-lysine N-methyltransferase that specifically methylates 'Lys-36' of histone H3 (H3K36me). It plays important roles in development; heterozygous mutation of ASH1L is associated with severe intellectual disability (ID) and multiple congenital anomaly (MCA).


Pssm-ID: 380951 [Multi-domain]  Cd Length: 141  Bit Score: 120.86  E-value: 1.29e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  18 GNGVFATRKIPAGTRIIEYGGKRISAEEADRRHPTNPDDPFHTFFFSLSSGRVIDGGDEGNDARWINHSCDPNCEAQE-- 95
Cdd:cd19174   11 GWGVRTKEPIKAGQFIIEYVGEVVSEQEFRRRMIEQYHNHSHHYCLNLDSGMVIDGYRMGNEARFVNHSCDPNCEMQKws 90

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 489914829  96 --GRHgkRVYIVALRDIARGEELFYDYGLVLDGritrkLKEGYRCLCGTTPCRG 147
Cdd:cd19174   91 vnGVY--RIGLFALKDIPAGEELTYDYNFHSFN-----VEKQQPCKCGSPNCRG 137
SET_SETD1-like cd10518
SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), ...
 10-146 6.54e-35

SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), histone-lysine N-methyltransferases (KMT2A/KMT2B/KMT2C/KMT2D) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A), 1B (SETD1B), as well as histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B), 2C (KMT2C), 2D (KMT2D). These proteins are histone-lysine N-methyltransferases (EC 2.1.1.43) that specifically methylate 'Lys-4' of histone H3 (H3K4me).


Pssm-ID: 380916  Cd Length: 150  Bit Score: 119.24  E-value: 6.54e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  10 SVRRSRLHGNGVFATRKIPAGTRIIEYGGKRISAEEADRRHPTNPDDPFH-TFFFSLSSGRVIDGGDEGNDARWINHSCD 88
Cdd:cd10518   17 RVGKSGIHGWGLFAKRPIAAGEMVIEYVGEVIRPIVADKREKRYDEEGGGgTYMFRIDEDLVIDATKKGNIARFINHSCD 96

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  89 PNCEAQEGRHG--KRVYIVALRDIARGEELFYDYglvldgRITRKLKEGYRCLCGTTPCR 146
Cdd:cd10518   97 PNCYAKIITVDgeKHIVIFAKRDIAPGEELTYDY------KFPIEDEEKIPCLCGAPNCR 150
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 11-126 1.20e-34

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 117.82  E-value: 1.20e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829    11 VRRSRLHGNGVFATRKIPAGTRIIEYGGKRISAEEADRRhPTNPDD--PFHTFFFSLSSGRVIDGGDEGNDARWINHSCD 88
Cdd:smart00317   5 VFKSPGKGWGVRATEDIPKGEFIGEYVGEIITSEEAEER-PKAYDTdgAKAFYLFDIDSDLCIDARRKGNLARFINHSCE 83

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 489914829    89 PNCEAQ--EGRHGKRVYIVALRDIARGEELFYDYGLVLDG 126
Cdd:smart00317  84 PNCELLfvEVNGDDRIVIFALRDIKPGEELTIDYGSDYAN 123
SET_SETD2-like cd10531
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), ...
 18-146 6.42e-33

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2), ASH1-like protein (ASH1L) and similar proteins; This family includes SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2) and ASH1-like protein (ASH1L), which function as histone-lysine N-methyltransferases. SETD2 specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. NSD2 shows histone H3 'Lys-27' (H3K27me) methyltransferase activity. ASH1L specifically methylates 'Lys-36' of histone H3 (H3K36me). The family also includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins.


Pssm-ID: 380929  Cd Length: 136  Bit Score: 113.50  E-value: 6.42e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  18 GNGVFATRKIPAGTRIIEYGGKRISAEEADRRHPTNPDDPF-HTFFFSLSSGRVIDGGDEGNDARWINHSCDPNCEAQ-- 94
Cdd:cd10531   11 GWGVKAKEDIQKGEFIIEYVGEVIDKKEFKERLDEYEELGKsNFYILSLSDDVVIDATRKGNLSRFINHSCEPNCETQkw 90

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 489914829  95 --EGRhgKRVYIVALRDIARGEELFYDYGLVldgritRKLKEGYRCLCGTTPCR 146
Cdd:cd10531   91 ivNGE--YRIGIFALRDIPAGEELTFDYNFV------NYNEAKQVCLCGAQNCR 136
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 18-121 1.10e-32

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 112.62  E-value: 1.10e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829   18 GNGVFATRKIPAGTRIIEY-GGKRISAEEADRRHPTNPD----DPFHTFFFSLS--SGRVIDGGDE--GNDARWINHSCD 88
Cdd:pfam00856   1 GRGLFATEDIPKGEFIGEYvEVLLITKEEADKRELLYYDklelRLWGPYLFTLDedSEYCIDARALyyGNWARFINHSCD 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 489914829   89 PNCEA--QEGRHGKRVYIVALRDIARGEELFYDYG 121
Cdd:pfam00856  81 PNCEVrvVYVNGGPRIVIFALRDIKPGEELTIDYG 115
SET_SETD2 cd19172
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and ...
 11-149 4.66e-32

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and similar proteins; SETD2 (also termed HIF-1, huntingtin yeast partner B, huntingtin-interacting protein 1 (HIP-1), huntingtin-interacting protein B, lysine N-methyltransferase 3A or protein-lysine N-methyltransferase SETD2) acts as histone-lysine N-methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. It has been shown that methylation is a posttranslational modification of dynamic microtubules and that SETD2 methylates alpha-tubulin at lysine 40, the same lysine that is marked by acetylation on microtubules. Methylation of microtubules occurs during mitosis and cytokinesis and can be ablated by SETD2 deletion, which causes mitotic spindle and cytokinesis defects, micronuclei, and polyploidy.


Pssm-ID: 380949 [Multi-domain]  Cd Length: 142  Bit Score: 111.52  E-value: 4.66e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  11 VRRSRLHGNGVFATRKIPAGTRIIEYGGKRISAEE-ADRRHPTNPDDPFHTFFFSLSSGRVIDGGDEGNDARWINHSCDP 89
Cdd:cd19172    6 VFRTEKKGWGLRAAEDLPKGTFVIEYVGEVLDEKEfKRRMKEYAREGNRHYYFMALKSDEIIDATKKGNLSRFINHSCEP 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489914829  90 NCEAQEGR-HGK-RVYIVALRDIARGEELFYDYGLVLDGritrklKEGYRCLCGTTPCRGTM 149
Cdd:cd19172   86 NCETQKWTvNGElRVGFFAKRDIPAGEELTFDYQFERYG------KEAQKCYCGSPNCRGYI 141
SET_KMT2A_2B cd19170
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), ...
 11-149 1.84e-29

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins; This family includes KMT2A and KMT2B. Both KMT2A (also termed ALL-1 or CXXC7 or MLL or MLL1 or TRX1 or HRX) and KMT2B (also termed MLL4 or TRX2) act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me).


Pssm-ID: 380947 [Multi-domain]  Cd Length: 152  Bit Score: 105.55  E-value: 1.84e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  11 VRRSRLHGNGVFATRKIPAGTRIIEYGGKRISAEEADRRHPTNPDDPFHTFFFSLSSGRVIDGGDEGNDARWINHSCDPN 90
Cdd:cd19170   18 VYRSPIHGRGLFCKRNIDAGEMVIEYAGEVIRSVLTDKREKYYESKGIGCYMFRIDDDEVVDATMHGNAARFINHSCEPN 97

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489914829  91 CEAQ----EGRhgKRVYIVALRDIARGEELFYDYGLVLDgritrklKEGYRCLCGTTPCRGTM 149
Cdd:cd19170   98 CYSRvvniDGK--KHIVIFALRRILRGEELTYDYKFPIE-------DVKIPCTCGSKKCRKYL 151
SET_KMT2C_2D cd19171
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), ...
 13-149 2.69e-29

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins; This family includes KMT2C and KMT2D. Both, KMT2C (also termed HALR or MLL3) and KMT2D (also termed ALR or MLL2), act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me). They are subunits of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation.


Pssm-ID: 380948 [Multi-domain]  Cd Length: 153  Bit Score: 104.82  E-value: 2.69e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  13 RSRLHGNGVFATRKIPAGTRIIEYGGKRISAEEADRRHPTNPDDPFHTFFFSLSSGRVIDGGDEGNDARWINHSCDPNCE 92
Cdd:cd19171   20 RSRIQGLGLYAARDIEKHTMVIEYIGEIIRNEVANRREKIYESQNRGIYMFRIDNDWVIDATMTGGPARYINHSCNPNCV 99

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 489914829  93 AQ--EGRHGKRVYIVALRDIARGEELFYDYGLVLDGRiTRKLKegyrCLCGTTPCRGTM 149
Cdd:cd19171  100 AEvvTFDKEKKIIIISNRRIAKGEELTYDYKFDFEDD-QHKIP----CLCGAPNCRKWM 153
SET_EZH cd10519
SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar ...
 13-121 1.29e-28

SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar proteins; The family includes EZH1 and EZH2. EZH1 (EC 2.1.1.43; also termed ENX-2, or histone-lysine N-methyltransferase EZH1) is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. EZH2 (EC 2.1.1.43; also termed lysine N-methyltransferase 6, ENX-1, or histone-lysine N-methyltransferase EZH2) is a catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Both, EZH1 and EZH2, can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively.


Pssm-ID: 380917  Cd Length: 117  Bit Score: 101.94  E-value: 1.29e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  13 RSRLHGNGVFATRKIPAGTRIIEYGGKRISAEEADRRHPTNpDDPFHTFFFSLSSGRVIDGGDEGNDARWINHSCDPNCE 92
Cdd:cd10519    7 KSDVAGWGLFLKEPIKKDEFIGEYTGELISQDEADRRGKIY-DKYNSSYLFNLNDQFVVDATRKGNKIRFANHSSNPNCY 85

                         90       100       110
                 ....*....|....*....|....*....|...
gi 489914829  93 AQ----EGRHgkRVYIVALRDIARGEELFYDYG 121
Cdd:cd10519   86 AKvmmvNGDH--RIGIFAKRDIEAGEELFFDYG 116
SET_SET1 cd20072
SET domain (including post-SET domain) found in catalytic component of the Saccharomyces ...
 13-146 4.36e-26

SET domain (including post-SET domain) found in catalytic component of the Saccharomyces cerevisiae COMPASS complex and similar proteins; The family contains mostly fungal SET domains, including SET1 found in the catalytic component of the Saccharomyces cerevisiae COMPASS (complex of proteins associated with Set1). SET1 is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me), when part of the SET1 histone methyltransferase (HMT) complex. The activity of this catalytic domain is established through forming a complex with a set of core proteins; it is extensively contacted by Cps60 (Bre2), Cps50 (Swd1), and Cps30 (Swd3).


Pssm-ID: 380998  Cd Length: 148  Bit Score: 96.72  E-value: 4.36e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  13 RSRLHGNGVFATRKIPAGTRIIEYGGKRISAEEAD-RRHPTNPDDPFHTFFFSLSSGRVIDGGDEGNDARWINHSCDPNC 91
Cdd:cd20072   19 RSAIHNWGLYAMENISAKDMVIEYVGEVIRQQVADeREKRYLRQGIGSSYLFRIDDDTVVDATKKGNIARFINHCCDPNC 98

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 489914829  92 EAQ----EGRhgKRVYIVALRDIARGEELFYDYGLVLDgritrklKEGYRCLCGTTPCR 146
Cdd:cd20072   99 TAKiikvEGE--KRIVIYAKRDIAAGEELTYDYKFPRE-------EDKIPCLCGAPNCR 148
SET_LegAS4-like cd10522
SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and ...
 10-121 5.17e-26

SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and similar proteins; LegAS4 is a type IV secretion system effector of Legionella pneumophila. It contains a SET domain that is involved in the modification of Lys4 of histone H3 (H3K4) in the nucleolus of the host cell, thereby enhancing heterochromatic rDNA transcription. It also contains an ankyrin repeat domain of unknown function at its C-terminal region.


Pssm-ID: 380920 [Multi-domain]  Cd Length: 122  Bit Score: 95.49  E-value: 5.17e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  10 SVRRSRLHGNGVFATRKIPAGTRIIEYGGKRISAEEADRRhPTNPDDPfhTFFFSLS-SGRVIDGGDEGNDARWINHSCD 88
Cdd:cd10522    6 MIPNLSHNGLGLFAAETIAKGEFVGEYTGEVLDRWEEDRD-SVYHYDP--LYPFDLNgDILVIDAGKKGNLTRFINHSDQ 82

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 489914829  89 PNCEA----QEGRHgkRVYIVALRDIARGEELFYDYG 121
Cdd:cd10522   83 PNLELivrtLKGEQ--HIGFVAIRDIKPGEELFISYG 117
SET_SETD1 cd19169
SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and ...
 13-146 1.26e-24

SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A) and SET domain-containing protein 1B (SETD1B). These proteins are histone-lysine N-methyltransferases that specifically methylate 'Lys-4' of histone H3 (H3K4me) when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated.


Pssm-ID: 380946  Cd Length: 148  Bit Score: 92.79  E-value: 1.26e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  13 RSRLHGNGVFATRKIPAGTRIIEYGGKRISAEEADRRHPTNPDDPF-HTFFFSLSSGRVIDGGDEGNDARWINHSCDPNC 91
Cdd:cd19169   19 KSRIHDWGLFALEPIAADEMVIEYVGQVIRQSVADEREKRYEAIGIgSSYLFRVDDDTIIDATKCGNLARFINHSCNPNC 98

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  92 EAQ----EGRhgKRVYIVALRDIARGEELFYDYGLVL-DGRItrklkegyRCLCGTTPCR 146
Cdd:cd19169   99 YAKiitvESQ--KKIVIYSKRPIAVNEEITYDYKFPIeDEKI--------PCLCGAPQCR 148
SET_KMT2A cd19206
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A) ...
 11-146 1.50e-24

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A) and similar proteins; KMT2A (EC2.1.1.43; also termed lysine N-methyltransferase 2A, ALL-1, CXXC-type zinc finger protein 7 (CXXC7), myeloid/lymphoid or mixed-lineage leukemia (MLL), myeloid/lymphoid or mixed-lineage leukemia protein 1 (MLL1), trithorax-like protein (TRX1), or zinc finger protein HRX) acts as a histone methyltransferase that plays an essential role in early development and hematopoiesis. It is a catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac).


Pssm-ID: 380983 [Multi-domain]  Cd Length: 154  Bit Score: 92.78  E-value: 1.50e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  11 VRRSRLHGNGVFATRKIPAGTRIIEYGGKRISAEEADRRHPTNPDDPFHTFFFSLSSGRVIDGGDEGNDARWINHSCDPN 90
Cdd:cd19206   18 VYRSPIHGRGLFCKRNIDAGEMVIEYSGNVIRSILTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPN 97

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  91 CEAQ----EGRhgKRVYIVALRDIARGEELFYDYGLVLDgRITRKLKegyrCLCGTTPCR 146
Cdd:cd19206   98 CYSRviniDGQ--KHIVIFAMRKIYRGEELTYDYKFPIE-DASNKLP----CNCGAKKCR 150
SET_ASHR3-like cd19175
SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 ...
 18-149 2.08e-24

SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins; This family includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3, also termed protein SET DOMAIN GROUP 4 or protein stamen loss), ASH1 homolog 3 (ASHH3, also termed protein SET DOMAIN GROUP 7) and homolog 4 (ASHH4, also termed protein SET DOMAIN GROUP 24). They all function as histone-lysine N-methyltransferases (EC 2.1.1.43).


Pssm-ID: 380952 [Multi-domain]  Cd Length: 139  Bit Score: 92.09  E-value: 2.08e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  18 GNGVFATRKIPAGTRIIEYGGKRISAEEADRRHPTNPDDPFHTFFF-SLSSGRVIDGGDEGNDARWINHSCDPNCEAQ-- 94
Cdd:cd19175   11 GWGLVADEDINAGEFIIEYVGEVIDDKTCEERLWDMKHKGEKNFYMcEIDKDMVIDATFKGNLSRFINHSCDPNCELQkw 90

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 489914829  95 --EGRhgKRVYIVALRDIARGEELFYDYGLVLDGritrklkEGYRCLCGTTPCRGTM 149
Cdd:cd19175   91 qvDGE--TRIGVFAIRDIKKGEELTYDYQFVQFG-------ADQDCHCGSKNCRGKL 138
SET_NSD cd19173
SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, ...
 18-147 3.17e-24

SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, NSD2, NSD3 and similar proteins; The nuclear receptor-binding SET Domain (NSD) family of histone H3 lysine 36 methyltransferases is comprised of NSD1, NSD2, and NSD3, which are primarily known to be involved in chromatin integrity and gene expression through mono-, di-, or tri-methylating lysine 36 of histone H3 (H3K36), respectively. NSD1 (EC 2.1.1.43; also termed histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific, androgen receptor coactivator 267 kDa protein (ARA267), androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, lysine N-methyltransferase 3B (KMT3B) or NR-binding SET domain-containing protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4. NSD2 (EC 2.1.1.43; also termed multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1)) acts as histone-lysine N-methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity. NSD3 (EC 2.1.1.43; also termed protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1), or WHSC1-like protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-4' and 'Lys-27' of histone H3.


Pssm-ID: 380950 [Multi-domain]  Cd Length: 142  Bit Score: 91.61  E-value: 3.17e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  18 GNGVFATRKIPAGTRIIEYGGKRISAEEADRR-HPTNPDDPFHTFFFSLSSGRVIDGGDEGNDARWINHSCDPNCEAQE- 95
Cdd:cd19173   13 GWGLRTKRDIKKGDFVIEYVGELIDEEECRRRlKKAHENNITNFYMLTLDKDRIIDAGPKGNLSRFMNHSCQPNCETQKw 92

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 489914829  96 ---GRHgkRVYIVALRDIARGEELFYDYGLVLDGriTRKLKegyrCLCGTTPCRG 147
Cdd:cd19173   93 tvnGDT--RVGLFAVRDIPAGEELTFNYNLDCLG--NEKKV----CRCGAPNCSG 139
SET_NSD2 cd19211
SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) ...
 7-147 2.95e-21

SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins; NSD2 (EC 2.1.1.43; also termed multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1)) acts as histone-lysine N-methyltransferase with histone H3 'Lys-36' (H3K36me) methyltransferase activity. NSD2 has been shown to mediate di- and trimethylation of H3K36 and dimethylation of H4K20 in different systems, and has been characterized as a transcriptional repressor interacting with histone deacetylase HDAC1 and histone demethylase LSD1. NSD2 mediates constitutive NF-kappaB signaling for cancer cell proliferation, survival and tumor growth. It is highly overexpressed in several types of human cancers, including small-cell lung cancers, neuroblastoma, carcinomas of stomach and colon, and bladder cancers, and its overexpression tends to be associated with tumor aggressiveness. WHSC1 is frequently deleted in Wolf-Hirschhorn syndrome (WHS).


Pssm-ID: 380988 [Multi-domain]  Cd Length: 142  Bit Score: 83.89  E-value: 2.95e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829   7 PWHSVRRSRLHGNGVFATRKIPAGTRIIEYGGKRISAEEA-DRRHPTNPDDPFHTFFFSLSSGRVIDGGDEGNDARWINH 85
Cdd:cd19211    2 PETKIIKTEGKGWGLIAKRDIKKGEFVNEYVGELIDEEECmARIKHAHENDITHFYMLTIDKDRIIDAGPKGNYSRFMNH 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489914829  86 SCDPNCEAQEG--RHGKRVYIVALRDIARGEELFYDYGLVLDGritrklKEGYRCLCGTTPCRG 147
Cdd:cd19211   82 SCQPNCETQKWtvNGDTRVGLFAVCDIPAGTELTFNYNLDCLG------NEKTVCRCGAPNCSG 139
SET_KMT2B cd19207
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2B (KMT2B) ...
 11-146 8.32e-21

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2B (KMT2B) and similar proteins; KMT2B (EC2.1.1.43; also termed lysine N-methyltransferase 2B, myeloid/lymphoid or mixed-lineage leukemia protein 4 (MLL2/MLL4), trithorax homolog 2 (TRX2), or WW domain-binding protein 7 (WBP-7)), acts as a histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me). It is required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that precedes resumption of meiosis, oocyte survival and normal zygotic genome activation.


Pssm-ID: 380984 [Multi-domain]  Cd Length: 154  Bit Score: 83.15  E-value: 8.32e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  11 VRRSRLHGNGVFATRKIPAGTRIIEYGGKRISAEEADRRHPTNPDDPFHTFFFSLSSGRVIDGGDEGNDARWINHSCDPN 90
Cdd:cd19207   18 VYRSAIHGRGLFCKRNIDAGEMVIEYSGIVIRSVLTDKREKFYDSKGIGCYMFRIDDFDVVDATMHGNAARFINHSCEPN 97

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  91 CEAQ----EGRhgKRVYIVALRDIARGEELFYDYGLVLDGrITRKLKegyrCLCGTTPCR 146
Cdd:cd19207   98 CYSRvihvEGQ--KHIVIFALRKIYRGEELTYDYKFPIED-ASNKLP----CNCGAKRCR 150
SET_SETD1A cd19204
SET domain (including post-SET domain) found in SET domain-containing protein 1A (SETD1A) and ...
 13-149 1.04e-20

SET domain (including post-SET domain) found in SET domain-containing protein 1A (SETD1A) and similar proteins; SETD1A (EC2.1.1.43), also termed lysine N-methyltransferase 2F, or Set1/Ash2 histone methyltransferase complex subunit SET1, is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me), when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. Human SET domain containing protein 1A (hSETD1A) expression occurs at a high rate in hepatocellular carcinoma patients and controls tumor metastasis in breast cancer by activating MMP expression.


Pssm-ID: 380981 [Multi-domain]  Cd Length: 153  Bit Score: 83.15  E-value: 1.04e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  13 RSRLHGNGVFATRKIPAGTRIIEYGGKRISAEEADRRHPTNPDDPF-HTFFFSLSSGRVIDGGDEGNDARWINHSCDPNC 91
Cdd:cd19204   20 RSRIHEWGLFAMEPIAADEMVIEYVGQNIRQVVADMREKRYVQEGIgSSYLFRVDHDTIIDATKCGNLARFINHCCTPNC 99

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489914829  92 EAQ----EGRhgKRVYIVALRDIARGEELFYDYGLVL-DGRITrklkegyrCLCGTTPCRGTM 149
Cdd:cd19204  100 YAKvitiESQ--KKIVIYSKQPIGVNEEITYDYKFPIeDNKIP--------CLCGTENCRGTL 152
SET cd08161
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ...
 10-121 5.44e-20

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site.


Pssm-ID: 380914 [Multi-domain]  Cd Length: 72  Bit Score: 78.83  E-value: 5.44e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  10 SVRRSRLHGNGVFATRKIPAGTRIIEyggkrisaeeadrrhptnpddpfhtfffslssgrvidggdegndARWINHSCDP 89
Cdd:cd08161    3 RPSTIPGAGFGLFATRDIPKGEVIGL--------------------------------------------ARFINHSCEP 38

                         90       100       110
                 ....*....|....*....|....*....|....
gi 489914829  90 NCEAQEGRHG--KRVYIVALRDIARGEELFYDYG 121
Cdd:cd08161   39 NCEFEEVYVGgkPRVFIVALRDIKAGEELTVDYG 72
SET_KMT2C cd19208
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C) ...
 13-149 8.65e-20

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C) and similar proteins; KMT2C (EC2.1.1.43; also termed lysine N-methyltransferase 2C, homologous to ALR protein (HALR) myeloid/lymphoid, or mixed-lineage leukemia protein 3 (MLL3)), acts as a histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me) and may be involved in leukemogenesis and developmental disorder. KMT2C is a catalytic subunit of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. Overexpression of KMT2C is associated with estrogen receptor-positive breast cancer; KMT2C mediates the estrogen dependence of breast cancer through regulation of estrogen receptor alpha (ERalpha) enhancer function. KMT2C is frequently mutated in certain populations with diffuse-type gastric adenocarcinomas (DGA); its loss promotes epithelial-to-mesenchymal transition (EMT) and is associated with worse overall survival.


Pssm-ID: 380985 [Multi-domain]  Cd Length: 154  Bit Score: 80.44  E-value: 8.65e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  13 RSRLHGNGVFATRKIPAGTRIIEYGGKRISAEEADRRHPTNPDDPFHTFFFSLSSGRVIDGGDEGNDARWINHSCDPNC- 91
Cdd:cd19208   21 RSRIQGLGLYAARDIEKHTMVIEYIGTIIRNEVANRKEKLYESQNRGVYMFRIDNDHVIDATLTGGPARYINHSCAPNCv 100

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 489914829  92 -EAQEGRHGKRVYIVALRDIARGEELFYDYGLVLDGRitrklKEGYRCLCGTTPCRGTM 149
Cdd:cd19208  101 aEVVTFEKGHKIIISSSRRIQKGEELCYDYKFDFEDD-----QHKIPCHCGAVNCRKWM 154
SET_SETD1B cd19205
SET domain (including post-SET domain) found in SET domain-containing protein 1B (SETD1B) and ...
 13-149 1.59e-19

SET domain (including post-SET domain) found in SET domain-containing protein 1B (SETD1B) and similar proteins; SETD1B (EC2.1.1.43), also termed lysine N-methyltransferase 2G, is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me) when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. Loss of SETD1B occurs in up to half the gastric and colorectal cancers, most commonly via SETD1B mutations, while de novo variants in SETD1B are associated with intellectual disability, epilepsy and autism.


Pssm-ID: 380982 [Multi-domain]  Cd Length: 153  Bit Score: 80.10  E-value: 1.59e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  13 RSRLHGNGVFATRKIPAGTRIIEYGGKRISAEEADRRHPTNPDDPF-HTFFFSLSSGRVIDGGDEGNDARWINHSCDPNC 91
Cdd:cd19205   20 KSHIHDWGLFAMEPIAADEMVIEYVGQNIRQVIADMREKRYEDEGIgSSYMFRVDHDTIIDATKCGNFARFINHSCNPNC 99

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  92 EAQ--EGRHGKRVYIVALRDIARGEELFYDYGLVLDgritrklKEGYRCLCGTTPCRGTM 149
Cdd:cd19205  100 YAKviTVESQKKIVIYSKQHINVNEEITYDYKFPIE-------DVKIPCLCGSENCRGTL 152
SET_SETDB-like cd10538
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 11-121 1.89e-19

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2, and similar proteins; The family includes SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2. SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis. SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. This family also includes the pre-SET domain, which is found in a number of histone methyltransferases (HMTase), N-terminal to the SET domain. Pre-SET domain is a zinc binding motif which contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilizing SET domains. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380936 [Multi-domain]  Cd Length: 217  Bit Score: 81.26  E-value: 1.89e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  11 VRRSRLHGNGVFATRKIPAGTRIIEYGGKRISAEEADRRHPTNpDDPFHTFFFSL-----SSGRV----IDGGDEGNDAR 81
Cdd:cd10538   93 VFRTSKKGWGVRSLEFIPKGSFVCEYVGEVITTSEADRRGKIY-DKSGGSYLFDLdefsdSDGDGeelcVDATFCGNVSR 171

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 489914829  82 WINHSCDPNCEAQ------EGRHGKRVYIVALRDIARGEELFYDYG 121
Cdd:cd10538  172 FINHSCDPNLFPFnvvidhDDLRYPRIALFATRDILPGEELTFDYG 217
SET_SETMAR cd10544
SET domain (including pre-SET and post-SET domains) found in SET domain and mariner ...
 11-147 2.32e-19

SET domain (including pre-SET and post-SET domains) found in SET domain and mariner transposase fusion protein (SETMAR) and similar proteins; SETMAR (also termed metnase) is a DNA-binding protein that is indirectly recruited to sites of DNA damage through protein-protein interactions. It has a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity. SETMAR also acts as a histone-lysine N-methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3. It specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining.


Pssm-ID: 380942 [Multi-domain]  Cd Length: 254  Bit Score: 81.58  E-value: 2.32e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  11 VRRSRLHGNGVFATRKIPAGTRIIEYGGKRISAEEADRR-HPTNPDDPFHTFFFS--LSSGRV----IDGGDEGNDARWI 83
Cdd:cd10544   94 VFKTPKKGWGLRTLEFIPKGRFVCEYAGEVIGFEEARRRtKSQTKGDMNYIIVLRehLSSGKVletfVDPTYIGNIGRFL 173

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489914829  84 NHSCDPNCEAQEGRHGK---RVYIVALRDIARGEELFYDYG------------LVLDGRITRKLkegyrCLCGTTPCRG 147
Cdd:cd10544  174 NHSCEPNLFMVPVRVDSmvpKLALFAARDIVAGEELSFDYSgefsnsvesvtlARQDESKSRKP-----CLCGAENCRG 247
SET_SUV39H cd10542
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 18-147 2.49e-19

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homologs, SUV39H1, SUV39H2 and similar proteins; This family includes SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. Also included are Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (SUV39H homolog) and Neurospora crassa DIM-5, both of which also methylate 'Lys-9' of histone H3.


Pssm-ID: 380940 [Multi-domain]  Cd Length: 245  Bit Score: 81.57  E-value: 2.49e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  18 GNGVFATRKIPAGTRIIEYGGKRISAEEADRRHpTNPDDPFHTFFFSL-----SSGRVIDGGDEGNDARWINHSCDPNCE 92
Cdd:cd10542   99 GWGVKTLEDIKKGTFVMEYVGEIITSEEAERRG-KIYDANGRTYLFDLdynddDCEYTVDAAYYGNISHFINHSCDPNLA 177

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489914829  93 A------QEGRHGKRVYIVALRDIARGEELFYDYGLVLDG-----RITRKLKEGYRCLCGTTPCRG 147
Cdd:cd10542  178 VyavwinHLDPRLPRIAFFAKRDIKAGEELTFDYLMTGTGgssesTIPKPKDVRVPCLCGSKNCRK 243
SET_KMT2D cd19209
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) ...
 13-149 7.78e-19

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins; KMT2D (EC2.1.1.43; also termed lysine N-methyltransferase 2D, ALL1-related protein (ALR), or myeloid/lymphoid or mixed-lineage leukemia protein 2 (MLL2)), acts as histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me). It is a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription. KMT2D is a subunit of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation.


Pssm-ID: 380986 [Multi-domain]  Cd Length: 155  Bit Score: 78.20  E-value: 7.78e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  13 RSRLHGNGVFATRKIPAGTRIIEYGGKRISAEEADRRHPTNPDDPFHTFFFSLSSGRVIDGGDEGNDARWINHSCDPNCE 92
Cdd:cd19209   22 RSRIQGLGLYAAKDLEKHTMVIEYIGTIIRNEVANRREKIYEEQNRGIYMFRINNEHVIDATLTGGPARYINHSCAPNCV 101

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 489914829  93 AQEGRHGK--RVYIVALRDIARGEELFYDYGLVLDGRitrklKEGYRCLCGTTPCRGTM 149
Cdd:cd19209  102 AEVVTFDKedKIIIISSRRIPKGEELTYDYQFDFEDD-----QHKIPCHCGAWNCRKWM 155
SET_SETD5-like cd10529
SET domain found in SET domain-containing protein 5 (SETD5), inactive histone-lysine ...
 20-120 9.02e-19

SET domain found in SET domain-containing protein 5 (SETD5), inactive histone-lysine N-methyltransferase 2E (KMT2E) and similar proteins; SETD5 is a probable transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. KMT2E (also termed inactive lysine N-methyltransferase 2E or myeloid/lymphoid or mixed-lineage leukemia protein 5 (MLL5)) associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. The family also includes Saccharomyces cerevisiae SET domain-containing proteins, SET3 and SET4, and Schizosaccharomyces pombe SET3. Most of these family members contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380927  Cd Length: 127  Bit Score: 77.31  E-value: 9.02e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  20 GVFATRKIPAGTRIIEYGGKRISAEEADRRHP-TNPDDPFHtFFFSLSSGR--VIDGGDEGNDARWINHSCDPNCEAQEG 96
Cdd:cd10529   18 GLVATEDISPGEPILEYKGEVSLRSEFKEDNGfFKRPSPFV-FFYDGFEGLplCVDARKYGNEARFIRRSCRPNAELRHV 96

                         90       100
                 ....*....|....*....|....*....
gi 489914829  97 RHGK---RVYIVALRDIARGEELF--YDY 120
Cdd:cd10529   97 VVSNgelRLFIFALKDIRKGTEITipFDY 125
SET_EZH2 cd19218
SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins; EZH2 (EC 2.1.1.43) ...
 14-120 1.48e-18

SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins; EZH2 (EC 2.1.1.43), also termed lysine N-methyltransferase 6, or ENX-1, or histone-lysine N-methyltransferase EZH2, is a catalytic subunit of the polycomb repressive complex 2 (PRC2)/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. It can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. PRC2 is involved in several cancers; EZH2 is overexpressed in breast, liver and prostate cancer, while point mutations in EZH2 alter the substrate preference and product specificity of PRC2 in Non-Hodgkin lymphomas (NHLs). Thus, PRC2 is a popular target for cancer therapeutics.


Pssm-ID: 380995  Cd Length: 120  Bit Score: 76.49  E-value: 1.48e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  14 SRLHGNGVFATRKIPAGTRIIEYGGKRISAEEADRRHPTNpDDPFHTFFFSLSSGRVIDGGDEGNDARWINHSCDPNCEA 93
Cdd:cd19218   11 SDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVY-DKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYA 89

                         90       100       110
                 ....*....|....*....|....*....|.
gi 489914829  94 Q----EGRHgkRVYIVALRDIARGEELFYDY 120
Cdd:cd19218   90 KvmmvNGDH--RIGIFAKRAIQTGEELFFDY 118
SET_EHMT cd10543
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 10-146 2.52e-18

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase EHMT1, EHMT2 and similar proteins; This family includes EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380941 [Multi-domain]  Cd Length: 231  Bit Score: 78.53  E-value: 2.52e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  10 SVRRSRLHGNGVFATRKIPAGTRIIEYGGKRISAEEADRRHptnpDDpfhTFFFSLSS----GRVIDGGDEGNDARWINH 85
Cdd:cd10543   94 QLFRTRGMGWGVRALQDIPKGTFVCEYIGELISDSEADSRE----DD---SYLFDLDNkdgeTYCIDARRYGNISRFINH 166

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  86 SCDPNC-------EAQEGRHgKRVYIVALRDIARGEELFYDYGlvlDG--RITRKLkegYRCLCGTTPCR 146
Cdd:cd10543  167 LCEPNLipvrvfvEHQDLRF-PRIAFFASRDIKAGEELGFDYG---EKfwRIKGKY---FTCRCGSPKCK 229
SET_SMYD cd20071
SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing ...
 14-140 3.74e-17

SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing protein, and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1-SYMD5. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions.


Pssm-ID: 380997 [Multi-domain]  Cd Length: 122  Bit Score: 72.80  E-value: 3.74e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  14 SRLHGNGVFATRKIPAGTRIIEyggkrisaEEADRRHPTN------PDDPFHTFFFSLSSGrvidggdegndarwINHSC 87
Cdd:cd20071    6 EGSKGRGLVATRDIEPGELILV--------EKPLVSVPSNsfsltdGLNEIGVGLFPLASL--------------LNHSC 63

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 489914829  88 DPNCEAqEGRHGKRVYIVALRDIARGEELFYDYGLVLDGRITR--KLKEGYRCLC 140
Cdd:cd20071   64 DPNAVV-VFDGNGTLRVRALRDIKAGEELTISYIDPLLPRTERrrELLEKYGFTC 117
SET_SETD8 cd10528
SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2. ...
 18-121 4.94e-17

SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2.1.1.43; also termed N-lysine methyltransferase KMT5A, H4-K20-HMTase KMT5A, lysine N-methyltransferase 5A, lysine-specific methylase 5A, PR/SET domain-containing protein 07, PR-Set7 or PR/SET07) is a nucleosomal histone-lysine N-methyltransferase that specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). It plays a central role in the silencing of euchromatic genes.


Pssm-ID: 380926 [Multi-domain]  Cd Length: 141  Bit Score: 72.99  E-value: 4.94e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  18 GNGVFATRKIPAGTRIIEYGGKRISAEEADRR---HPTNPDDPFHTFFFS-LSSGRVIDGGDE-GNDARWINHSC-DPNC 91
Cdd:cd10528   28 GRGVIATRPFEKGDFVVEYHGDLITITEAKKRealYAKDPSTGCYMYYFQyKGKTYCVDATKEsGRLGRLINHSKkKPNL 107

                         90       100       110
                 ....*....|....*....|....*....|....
gi 489914829  92 EAQ----EGRHgkRVYIVALRDIARGEELFYDYG 121
Cdd:cd10528  108 KTKllviDGVP--HLILVAKRDIKPGEELLYDYG 139
SET_NSD3 cd19212
SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing ...
 2-147 7.52e-17

SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 3 (NSD3) and similar proteins; NSD3 (EC 2.1.1.43; also termed protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1), or WHSC1-like protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. NSD3 is amplified and overexpressed in multiple cancer types, including acute myeloid leukemia (AML), breast, lung, pancreatic and bladder cancers, as well as squamous cell carcinoma of the head and neck (SCCHN). NSD3 contributes to tumorigenesis by interacting with bromodomain-containing protein 4 (BRD4), the bromodomain and extraterminal (BET) protein, which is a potential therapeutic target in acute myeloid leukemia (AML). NSD3 is amplified in primary tumors and cell lines from breast carcinoma, and can promote the cell viability of small-cell lung cancer and pancreatic ductal adenocarcinoma. High NSD3 expression is implicated in poor grade and heavy smoking history in SCCHN. Thus, NSD3 may serve as a potential druggable target for selective cancer therapy.


Pssm-ID: 380989 [Multi-domain]  Cd Length: 142  Bit Score: 72.65  E-value: 7.52e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829   2 TEIIKpwhSVRRsrlhGNGVFATRKIPAGTRIIEYGGKRISAEEADRRHPTNPDDPFHTFF-FSLSSGRVIDGGDEGNDA 80
Cdd:cd19212    4 AEIIK---TERR----GWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYmLTVTKDRIIDAGPKGNYS 76

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489914829  81 RWINHSCDPNCEAQEGR-HGK-RVYIVALRDIARGEELFYDYGLVLDGRITRKlkegyrCLCGTTPCRG 147
Cdd:cd19212   77 RFMNHSCNPNCETQKWTvNGDvRVGLFALCDIPAGMELTFNYNLDCLGNGRTE------CHCGADNCSG 139
SET_EZH1 cd19217
SET domain found in enhancer of zeste homolog 1 (EZH1) and similar proteins; EZH1 (EC 2.1.1.43) ...
 14-120 1.76e-16

SET domain found in enhancer of zeste homolog 1 (EZH1) and similar proteins; EZH1 (EC 2.1.1.43), also termed ENX-2, or histone-lysine N-methyltransferase EZH1, is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. It can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively.


Pssm-ID: 380994  Cd Length: 136  Bit Score: 71.64  E-value: 1.76e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  14 SRLHGNGVFATRKIPAGTRIIEYGGKRISAEEADRRHPTNpDDPFHTFFFSLSSGRVIDGGDEGNDARWINHSCDPNCEA 93
Cdd:cd19217   13 SDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRGKVY-DKYMSSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYA 91

                         90       100       110
                 ....*....|....*....|....*....|.
gi 489914829  94 Q----EGRHgkRVYIVALRDIARGEELFYDY 120
Cdd:cd19217   92 KvvmvNGDH--RIGIFAKRAIQQGEELFFDY 120
SET_EZH-like cd19168
SET domain found in enhancer of zeste homolog 1 (EZH1) and zeste homolog 2 (EZH2) of polycomb ...
 13-121 1.93e-16

SET domain found in enhancer of zeste homolog 1 (EZH1) and zeste homolog 2 (EZH2) of polycomb repressive complex 2 (PRC2), and similar proteins; The family includes EZH1 and EZH2. EZH1 (EC 2.1.1.43; also termed ENX-2, or histone-lysine N-methyltransferase EZH1) is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. EZH2 (EC 2.1.1.43; also termed lysine N-methyltransferase 6, ENX-1, or histone-lysine N-methyltransferase EZH2) is a catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Both EZH1 and EZH2 can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. PRC2 is involved in several cancers; EZH2 is overexpressed in breast, liver and prostate cancer, while point mutations in EZH2 alter the substrate preference and product specificity of PRC2 in Non-Hodgkin lymphomas (NHLs). Thus, PRC2 is a popular target for cancer therapeutics.


Pssm-ID: 380945  Cd Length: 124  Bit Score: 71.07  E-value: 1.93e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  13 RSRLH-GNGVFATRKIPAGTRIIEYGGKRISAEEADRRHPTNPDDPFHtFFFSLSSGRVIDGGDEGNDARWINHSCDP-- 89
Cdd:cd19168    7 KSQLEcGLGLFAAEDIKEGEFVIEYTGELISHDEGVRREHRRGDVSYL-YLFEEQEGIWVDAAIYGNLSRYINHATDKvk 85

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 489914829  90 --NCEAQ--EGRHGKRVYIVALRDIARGEELFYDYG 121
Cdd:cd19168   86 tgNCMPKimYVNHEWRIKFTAIKDIKIGEELFFNYG 121
SET_NSD1 cd19210
SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing ...
 13-147 3.51e-16

SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins; NSD1 (EC 2.1.1.43; also termed Histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific, androgen receptor coactivator 267 kDa protein (ARA267), androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, lysine N-methyltransferase 3B (KMT3B), or NR-binding SET domain-containing protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4. NSD1 is altered in approximately 10% of head and neck cancer patients with 55% decrease in risk of death in NSD1-mutated versus non-mutated patients; its disruption promotes favorable chemotherapeutic responses linked to hypomethylation.


Pssm-ID: 380987 [Multi-domain]  Cd Length: 142  Bit Score: 70.73  E-value: 3.51e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  13 RSRLHGNGVFATRKIPAGTRIIEYGGKRISAEEADRR-HPTNPDDPFHTFFFSLSSGRVIDGGDEGNDARWINHSCDPNC 91
Cdd:cd19210    8 RTLGRGWGLRCKTDIKKGEFVNEYVGELIDEEECRARiRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNC 87

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  92 EAQEG--RHGKRVYIVALRDIARGEELFYDYGL--VLDGRITrklkegyrCLCGTTPCRG 147
Cdd:cd19210   88 ETQKWtvNGDTRVGLFALCDIKAGTELTFNYNLecLGNGKTV--------CKCGAPNCSG 139
SET_SUV39H_DIM5-like cd19473
SET domain (including pre-SET domain) found in Neurospora crassa (DIM-5) and similar proteins; ...
 18-147 6.31e-15

SET domain (including pre-SET domain) found in Neurospora crassa (DIM-5) and similar proteins; This subfamily contains Neurospora crassa DIM-5 (also termed H3-K9-HMTase dim-5, or HKMT) which functions as histone-lysine N-methyltransferase that specifically trimethylates histone H3 to form H3K9me3.


Pssm-ID: 380996 [Multi-domain]  Cd Length: 274  Bit Score: 70.04  E-value: 6.31e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  18 GNGVFATRKIPAGTRIIEYGGKRISAEEADRRHP------------------TNPDDPFHTFffsLSSGRVIDGGDEGND 79
Cdd:cd19473  117 GWGVRSTVDIKRGQFVDCYVGEIITPEEAQRRRDaatiaqrkdvylfaldkfSDPDSLDPRL---RGDPYEIDGEFMSGP 193

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489914829  80 ARWINHSCDPNCE--AQEGRHGKR----VYIVALRDIARGEELFYDY-----GLVLDGRITRKLKEGYRCLCGTTPCRG 147
Cdd:cd19473  194 TRFINHSCDPNLRifARVGDHADKhihdLAFFAIKDIPRGTELTFDYvdgvtGLDDDAGDEEKEKEMTKCLCGSPKCRG 272
SET_EHMT2 cd10533
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 13-156 1.08e-14

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 2 (EHMT2) and similar proteins; EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C (KMT1C), or protein G9a) acts as a histone-lysine N-methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380931 [Multi-domain]  Cd Length: 239  Bit Score: 68.89  E-value: 1.08e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  13 RSRLHGNGVFATRKIPAGTRIIEYGGKRISAEEADRRHptnpDDpfhTFFFSLSS--GRV--IDGGDEGNDARWINHSCD 88
Cdd:cd10533   97 RTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVRE----DD---SYLFDLDNkdGEVycIDARYYGNISRFINHLCD 169

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489914829  89 PNC------EAQEGRHGKRVYIVALRDIARGEELFYDYGlvldGRITRKLKEGYRCLCGTTPCRGTMLALPEKK 156
Cdd:cd10533  170 PNIipvrvfMLHQDLRFPRIAFFSSRDIRTGEELGFDYG----DRFWDIKSKYFTCQCGSEKCKHSAEAIALEQ 239
SET_SUV39H_Clr4-like cd20073
SET domain (including pre-SET and post-SET domains) found in of Schizosaccharomyces pombe H3K9 ...
 18-147 1.78e-14

SET domain (including pre-SET and post-SET domains) found in of Schizosaccharomyces pombe H3K9 methyltransferase Clr4, and similar proteins; This subfamily contains fission yeast Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (also known as Suv39h), the sole homolog of the mammalian SUV39H1 and SUV39H2 enzymes, that has a critical role in preventing aberrant heterochromatin formation. It is known to di- and tri-methylate Lys-9 of histone H3, a central heterochromatic histone modification, with its specificity profile most similar to that of the human SUV39H2 homolog.


Pssm-ID: 380999 [Multi-domain]  Cd Length: 259  Bit Score: 68.75  E-value: 1.78e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  18 GNGVFATRKIPAGTRIIEYGGKRISAEEADRRHPtNPDDPFHTFFFSL-------SSGRVIDGGDEGNDARWINHSCDPN 90
Cdd:cd20073  104 GWGLRCPRFIKAGTFIGVYLGEVITQSEAEIRGK-KYDNVGVTYLFDLdlfedqvDEYYTVDAQYCGDVTRFINHSCDPN 182

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489914829  91 CE---AQEGRHGKRVY---IVALRDIARGEELFYDYGLVLD----GRITRKLKEGYR-------CLCGTTPCRG 147
Cdd:cd20073  183 LAiysVLRDKSDSKIYdlaFFAIKDIPALEELTFDYSGRNNfdqlGFIGNRSNSKYInlknkrpCYCGSANCRG 256
SET_EHMT1 cd10535
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 13-146 6.41e-14

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins; EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, or lysine N-methyltransferase 1D (KMT1D)) acts as a histone-lysine N-methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380933 [Multi-domain]  Cd Length: 231  Bit Score: 66.88  E-value: 6.41e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  13 RSRLHGNGVFATRKIPAGTRIIEYGGKRISAEEADRRHptnpDDpfhTFFFSLSS--GRV--IDGGDEGNDARWINHSCD 88
Cdd:cd10535   97 RTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVRE----ED---SYLFDLDNkdGEVycIDARFYGNVSRFINHHCE 169

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489914829  89 PNC------EAQEGRHGKRVYIVALRDIARGEELFYDYGlvldGRITRKLKEGYRCLCGTTPCR 146
Cdd:cd10535  170 PNLvpvrvfMAHQDLRFPRIAFFSTRLIEAGEQLGFDYG----ERFWDIKGKLFSCRCGSPKCR 229
SET_SUV39H2 cd10532
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 12-149 1.11e-13

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 2 (SUV39H2) and similar proteins; SUV39H2 (EC 2.1.1.43; also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B (KMT1B), or Su(var)3-9 homolog 2) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. It mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.


Pssm-ID: 380930 [Multi-domain]  Cd Length: 243  Bit Score: 66.45  E-value: 1.11e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  12 RRSRLHGNGVFATRKIPAGTRIIEYGGKRISAEEADRRHPTNpDDPFHTFFFSL---SSGRVIDGGDEGNDARWINHSCD 88
Cdd:cd10532   90 RTSNGRGWGVKTLQKIKKNSFVMEYVGEVITSEEAERRGQFY-DSKGITYLFDLdyeSDEFTVDAARYGNVSHFVNHSCD 168

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489914829  89 PNCEA------QEGRHGKRVYIVALRDIARGEELFYDYGLVLDGRITRK------LKEGYR--CLCGTTPCRGTM 149
Cdd:cd10532  169 PNLQVfnvfidNLDTRLPRIALFSTRTIKAGEELTFDYQMKGSGDLSSDsidnspAKKRVRtvCKCGAVTCRGYL 243
SET_SETDB1 cd10517
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 15-150 2.22e-13

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and similar proteins; SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes.


Pssm-ID: 380915 [Multi-domain]  Cd Length: 288  Bit Score: 65.77  E-value: 2.22e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  15 RLHgngVFATRK----------IPAGTRIIEYGGKRISAEEADRR----------------------HPTNPDDPFHTFf 62
Cdd:cd10517  130 RLQ---VFKTEKkgwgirclddIPKGSFVCIYAGQILTEDEANEEglqygdeyfaeldyievveklkEGYESDVEEHCY- 205

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  63 fslssgrVIDGGDEGNDARWINHSCDPNCEAQE---GRHGKR---VYIVALRDIARGEELFYDYGLVLDGRITRKLKegy 136
Cdd:cd10517  206 -------IIDAKSEGNLGRYLNHSCSPNLFVQNvfvDTHDLRfpwVAFFASRYIRAGTELTWDYNYEVGSVPGKVLY--- 275

                        170
                 ....*....|....
gi 489914829 137 rCLCGTTPCRGTML 150
Cdd:cd10517  276 -CYCGSSNCRGRLL 288
SET_SpSet7-like cd10540
SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces ...
 11-121 2.40e-13

SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces pombe Set7 is a novel histone-lysine N-methyltransferase. The family also includes a viral histone H3 lysine 27 methyltransferase from Paramecium bursaria Chlorella virus 1 (PBCV-1).


Pssm-ID: 380938  Cd Length: 112  Bit Score: 62.66  E-value: 2.40e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  11 VRRSRLHGNGVFATRKIPAGTRIIEYGGKRISAEEADRRHPTNPDDpfHTFFFslssgrvidggdeGNDARWI------- 83
Cdd:cd10540    4 VKPSTLKGRGVFATRPIKKGEVIEEAPVIVLPKEEYQHLCKTVLDH--YVFSW-------------GDGCLALalgygsm 68

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 489914829  84 -NHSCDPNCEAQEGRHGKRVYIVALRDIARGEELFYDYG 121
Cdd:cd10540   69 fNHSYTPNAEYEIDFENQTIVFYALRDIEAGEELTINYG 107
SET_SpSET3-like cd19183
SET domain (including post-SET domain) found in Schizosaccharomyces pombe SET ...
 20-122 5.13e-11

SET domain (including post-SET domain) found in Schizosaccharomyces pombe SET domain-containing protein 3 (SETD3) and similar proteins; Schizosaccharomyces pombe SETD3 functions as a transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. It is required for both, gene activation and repression.


Pssm-ID: 380960  Cd Length: 173  Bit Score: 57.80  E-value: 5.13e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  20 GVFATRKIPAGTRIIEYGGKRISAEEadrrHPTNPDDPF--------HTFFFSLSSgRVIDGGDEGNDARWINHSCDPNC 91
Cdd:cd19183   15 GLFADRPIPAGDPIQELLGEIGLQSE----YIADPENQYqilgapkpHVFFHPQSP-LYIDTRRSGSVARFIRRSCRPNA 89

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 489914829  92 EAQEGRHGK----RVYIVALRDIARGEELFYDYGL 122
Cdd:cd19183   90 ELVTVASDSgsvlKFVLYASRDISPGEEITIGWDW 124
SET_AtSUVH-like cd10545
SET domain found in Arabidopsis thaliana histone H3-K9 methyltransferases (SUVHs) and similar ...
 11-121 7.45e-11

SET domain found in Arabidopsis thaliana histone H3-K9 methyltransferases (SUVHs) and similar proteins; Arabidopsis thaliana SUVH protein (also termed suppressor of variegation 3-9 homolog protein) is a histone-lysine N-methyltransferase that methylates 'Lys-9' of histone H3. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression. Some family members contain a post-SET domain which binds a Zn2+ ion. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380943 [Multi-domain]  Cd Length: 232  Bit Score: 58.57  E-value: 7.45e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  11 VRRSRLHGNGVFATRKIPAGTRIIEYGGKRISAEEADRRHpTNPDDPFHTFFFS-------------------------- 64
Cdd:cd10545   90 VFKTAERGWGVRSWDSIPAGSFICEYVGELLDTSEADTRS-GNDDYLFDIDNRQtnrgwdggqrldvgmsdgerssaede 168

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489914829  65 LSSGRVIDGGDEGNDARWINHSCDPNCEAQEGRHGK------RVYIVALRDIARGEELFYDYG 121
Cdd:cd10545  169 ESSEFTIDAGSFGNVARFINHSCSPNLFVQCVLYDHndlrlpRVMLFAADNIPPLQELTYDYG 231
SET_SETDB cd10541
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1), ...
 18-147 3.97e-10

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1), SET domain bifurcated 2 (SETDB2), and similar proteins; SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis.


Pssm-ID: 380939 [Multi-domain]  Cd Length: 236  Bit Score: 56.40  E-value: 3.97e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  18 GNGVFATRKIPAGTRIIEYGGKRISAEEADRRHPTNPDDPFHTFFFSLSSGRVIDGGDEGNDARWINHSCDPNCEAQE-- 95
Cdd:cd10541  103 GWGIRCLDDIAKGTFVCIYAGKILTDDFADKEGLEMGDEYFANLDHIEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNvf 182

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 489914829  96 -GRHGKRVYIVAL---RDIARGEELFYDYGLVLDGRITRKLkegyRCLCGTTPCRG 147
Cdd:cd10541  183 vDTHDLRFPWVAFfasKRIKAGTELTWDYNYEVGSVEGKEL----LCCCGSNECRG 234
SET_Suv4-20-like cd10524
SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of ...
 13-121 6.74e-10

SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of variegation 4-20 (Suv4-20) and similar proteins; Suv4-20 (also termed Su(var)4-20) is a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-20' of histone H4. It acts as a dominant suppressor of position-effect variegation. The family also includes Suv4-20 homologs, lysine N-methyltransferase 5B (KMT5B) and lysine N-methyltransferase 5C (KMT5C). Both KMT5B (also termed lysine-specific methyltransferase 5B, or suppressor of variegation 4-20 homolog 1, or Su(var)4-20 homolog 1, or Suv4-20h1) and KMT5C (also termed lysine-specific methyltransferase 5C, or suppressor of variegation 4-20 homolog 2, or Su(var)4-20 homolog 2, or Suv4-20h2) are histone methyltransferases that specifically trimethylate 'Lys-20' of histone H4 (H4K20me3). They play central roles in the establishment of constitutive heterochromatin in pericentric heterochromatin regions.


Pssm-ID: 380922 [Multi-domain]  Cd Length: 141  Bit Score: 54.21  E-value: 6.74e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  13 RSRLHGNGVFATRKIPAGTRIIEYGG--KRISAEEADRRHPTNPDdpfhtffFSL--SSG----RVIDGgdegnDARWIN 84
Cdd:cd10524   14 LENHYGAKIIATKPIKKGEKIHELCGciAELSEEEEALLRPGGND-------FSVmySSRkkcsQLWLG-----PAAFIN 81

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 489914829  85 HSCDPNCEAQEgRHGKRVYIVALRDIARGEELFYDYG 121
Cdd:cd10524   82 HDCRPNCKFVP-TGKSTACVKVLRDIEPGEEITVYYG 117
SET_SUV39H1 cd10525
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 18-146 1.91e-09

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 1 (SUV39H1) and similar proteins; SUV39H1 (EC 2.1.1.43; also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A (KMT1A), position-effect variegation 3-9 homolog (SUV39H), or Su(var)3-9 homolog 1) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. It mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.


Pssm-ID: 380923 [Multi-domain]  Cd Length: 255  Bit Score: 54.90  E-value: 1.91e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  18 GNGVFATRKIPAGTRIIEYGGKRISAEEADRRHPTNpDDPFHTFFFSL---SSGRVIDGGDEGNDARWINHSCDPNCEAQ 94
Cdd:cd10525   98 GWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIY-DRQGATYLFDLdyvEDVYTVDAAYYGNISHFVNHSCDPNLQVY 176

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489914829  95 E------GRHGKRVYIVALRDIARGEELFYDYGLVLD---------------GRITRKLKEGYR--CLCGTTPCR 146
Cdd:cd10525  177 NvfidnlDERLPRIALFATRTIRAGEELTFDYNMQVDpvdaestkmdsnfglAGLPGSPKKRVRieCKCGVRSCR 251
SET_SETD7 cd10530
SET domain found in SET domain-containing protein 7 (SETD7) and similar proteins; SETD7 (EC 2. ...
 11-121 2.54e-09

SET domain found in SET domain-containing protein 7 (SETD7) and similar proteins; SETD7 (EC 2.1.1.43; also termed histone H3-K4 methyltransferase SETD7, H3-K4-HMTase SETD7, lysine N-methyltransferase 7 (KMT7) or SET7/9) is a histone-lysine N-methyltransferase that specifically monomethylates 'Lys-4' of histone H3. It plays a central role in the transcriptional activation of genes such as collagenase or insulin. Set7/9 also methylates non-histone proteins, including estrogen receptor alpha (ERa), suggesting it has a role in diverse biological processes. ERa methylation by Set7/9 stabilizes ERa and activates its transcriptional activities, which are involved in the carcinogenesis of breast cancer. In a high-throughput screen, treatment of human breast cancer cells (MCF7 cells) with cyproheptadine, a Set7/9 inhibitor, decreased the expression and transcriptional activity of ERa, thereby inhibiting estrogen-dependent cell growth.


Pssm-ID: 380928  Cd Length: 130  Bit Score: 52.30  E-value: 2.54e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  11 VRRSRLH--GNGVFATRKIPAGTRIIEYGGKRISAEEADRRhptnpDDPFHTFFFSLSSGRVIDGGDEGNDARW------ 82
Cdd:cd10530   11 VAESLIPsaGEGLFAKVAVGPNTVMSFYNGVRITHQEVDSR-----DWSLNGNTISLDEETVIDVPEPYNSVSKycaslg 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 489914829  83 --INHSCDPNCE---AQEGRHGKRVYIVALRDIARGEELFYDYG 121
Cdd:cd10530   86 hkANHSFTPNCIydpFVHPRFGPIKCIRTLRAVEAGEELTVAYG 129
SET_SMYD4 cd10536
SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing ...
 83-145 1.43e-08

SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing protein 4 (SMYD4) and similar proteins; SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. In zebrafish, SMYD4 is ubiquitously expressed in early embryos and becomes enriched in the developing heart; mutants show a strong defect in cardiomyocyte proliferation, which lead to a severe cardiac malformation.


Pssm-ID: 380934 [Multi-domain]  Cd Length: 218  Bit Score: 51.92  E-value: 1.43e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489914829  83 INHSCDPNCEAQegRHGKRVYIVALRDIARGEELFYDYG--LVLDGRITR--KLKEGYR--CLCgtTPC 145
Cdd:cd10536  154 LNHSCDPNTIRS--FYGNTIVVRATRPIKKGEEITICYGphFSRMKRSERqrLLKEQYFfdCSC--EAC 218
SET_LSMT cd10527
SET domain found in Rubisco large subunit methyltransferase (LSMT) and similar proteins; ...
 83-121 2.74e-07

SET domain found in Rubisco large subunit methyltransferase (LSMT) and similar proteins; Rubisco LSMT is a non-histone protein methyl transferase responsible for the trimethylation of lysine14 in the large subunit of Rubisco (ribulose-1,5-bisphosphate carboxylase/oxygenase). The family also includes SET domain-containing proteins, SETD3, SETD4 and SETD6, which belong to methyltransferase class VII that represents classical non-histone SET domain methyltransferases. Members in this family contain a SET domain and a C-terminal RubisCO LSMT substrate-binding (Rubis-subs-bind) domain.


Pssm-ID: 380925 [Multi-domain]  Cd Length: 236  Bit Score: 48.60  E-value: 2.74e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 489914829  83 INHSCD-PNCEAQEGRHGKRVYIVALRDIARGEELFYDYG 121
Cdd:cd10527  183 LNHSPDaPNVRYEYDEDEGSFVLVATRDIAAGEEVFISYG 222
SET_SMYD3 cd19203
SET domain (including post-SET domain) found in SET and MYND domain-containing protein 3 ...
 84-145 4.40e-07

SET domain (including post-SET domain) found in SET and MYND domain-containing protein 3 (SMYD3) and similar proteins; SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. It is overexpressed in colorectal, breast, prostate, and hepatocellular tumors, and has been implicated as an oncogene in human malignancies. Methylation of MEKK2 by SMYD3 is important for regulation of the MEK/ERK pathway, suggesting the possibility of selectively targeting SMYD3 in RAS-driven cancers.


Pssm-ID: 380980 [Multi-domain]  Cd Length: 210  Bit Score: 47.74  E-value: 4.40e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489914829  84 NHSCDPNCEAQegRHGKRVYIVALRDIARGEELFYDYGLVLDGRITRK--LKEGYRCLCGTTPC 145
Cdd:cd19203  147 NHSCDPNCVIV--FNGPHLLLRAIREIEVGEELTISYIDMLMPSEERRkqLRDQYCFECDCFRC 208
SET_KMT2E cd19182
SET domain found in inactive histone-lysine N-methyltransferase 2E (KMT2E) and similar ...
 23-121 4.86e-07

SET domain found in inactive histone-lysine N-methyltransferase 2E (KMT2E) and similar proteins; KMT2E (also termed inactive lysine N-methyltransferase 2E, myeloid/lymphoid or mixed-lineage leukemia protein 5 (MLL5)) plays a key role in hematopoiesis, spermatogenesis and cell cycle progression. It associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. Lack of key residues in the SET domain as well as the presence of an unusually large loop in the SET-I subdomain preclude the interaction of MLL5 SET with its cofactor and substrate thus making MLL5 devoid of any in vitro methyltransferase activity on full-length histones and histone H3 peptide.


Pssm-ID: 380959  Cd Length: 129  Bit Score: 46.42  E-value: 4.86e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  23 ATRKIPAGTRIIEYGGKRISAE--EADRRHPTNPDdPFhTFFFSLSSG--RVIDGGDEGNDARWINHSCDPNCEA----Q 94
Cdd:cd19182   23 AAKDLPPDTLIIEYRGKFMLREqfEANGYFFKRPY-PF-VLFYSKFHGleMCVDARTFGNEARFIRRSCTPNAEVrhviE 100

                         90       100       110
                 ....*....|....*....|....*....|.
gi 489914829  95 EGRhgKRVYIVALRDIARGEELF----YDYG 121
Cdd:cd19182  101 DGT--IHLYIYSIRSIPKGTEITiafdFDYG 129
PR-SET_PRDM7_9 cd19193
PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar ...
 10-121 4.95e-07

PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar proteins; PRDM7 (also termed PR domain-containing protein 7) is a primate-specific histone methyltransferase that is the result of a recent gene duplication of PRDM9. It selectively catalyzes the trimethylation of H3 lysine 4 (H3K4me3). PRDM9 (also termed PR domain-containing protein 9) is a histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 (H3K4me3) during meiotic prophase and is essential for proper meiotic progression. It also efficiently mono-, di-, and trimethylates H3K36. Aberrant PRDM9 expression is assciated with with genome instability in cancer.


Pssm-ID: 380970 [Multi-domain]  Cd Length: 129  Bit Score: 46.46  E-value: 4.95e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  10 SVRRS--RLHGNGVFATRKIPAGTRIIEYGGKRISAEEADRR----HPTNPDDPFHtfffslssgrVIDGGDEG--NDAR 81
Cdd:cd19193    9 SIKRSsiPGAGLGVWAEAPIPKGMVFGPYEGEIVEDEEAADSgyswQIYKGGKLSH----------YIDAKDESksNWMR 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 489914829  82 WIN---HSCDPNCEA-QegrHGKRVYIVALRDIARGEELFYDYG 121
Cdd:cd19193   79 YVNcarNEEEQNLVAfQ---YRGKIYYRTCKDIAPGTELLVWYG 119
SET_SMYD1_2_3-like cd19167
SET domain (including post-SET domain) found in SET and MYND domain-containing proteins, SMYD1, ...
 79-146 2.58e-06

SET domain (including post-SET domain) found in SET and MYND domain-containing proteins, SMYD1, SMYD2, SMYD3 and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1, SMYD2 and SMYD3. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex.


Pssm-ID: 380944 [Multi-domain]  Cd Length: 205  Bit Score: 45.49  E-value: 2.58e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  79 DARWINHSCDPNCEAQegRHGKRVYIVALRDIARGEELFYDY--GLVLDGRITRKLKEGYRCLCGTTPCR 146
Cdd:cd19167  137 QAALLNHSCCPNCIVT--FNGPNIEVRAVQEIEPGEEVFHSYidLLYPTEERRDQLRDQYFFLCQCADCQ 204
SET_SMYD5 cd10521
SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing ...
 83-146 3.36e-06

SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing protein 5 (SMYD5) and similar proteins; SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions. It plays an important role in chromosome integrity by regulating heterochromatin and repressing endogenous repetitive DNA elements during differentiation. In zebrafish embryogenesis, it plays pivotal roles in both primitive and definitive hematopoiesis.


Pssm-ID: 380919 [Multi-domain]  Cd Length: 282  Bit Score: 45.38  E-value: 3.36e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489914829  83 INHSCDPNCEAQEGRHGKRVYIVALRDIARGEELFYDYglvLD------GRITRK--LKEGYRCLCGTTPCR 146
Cdd:cd10521  212 CNHSCVPNAEITFPENNFTLSLKALRDIQEGEEICISY---LDecqrerSRHSRQkiLRENYLFICNCPKCE 280
PR-SET_PRDM12 cd19196
PR-SET domain found in PR domain zinc finger protein 12 (PRDM12) and similar proteins; PRDM12 ...
 20-121 4.06e-06

PR-SET domain found in PR domain zinc finger protein 12 (PRDM12) and similar proteins; PRDM12 (also termed PR domain-containing protein 12) acts as a transcription factor that is involved in the positive regulation of histone H3-K9 dimethylation.


Pssm-ID: 380973 [Multi-domain]  Cd Length: 130  Bit Score: 43.88  E-value: 4.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  20 GVFATRKIPAGTRIIEYGGKRISAEEADrrhpTNPDDPFHTFFFSlSSGRV---IDGGDEgNDARWINH-SCDPNCEAQE 95
Cdd:cd19196   18 GVFSKTWIKEGTEMGPYTGRIVSPEDVD----PCKNNNLMWEVFN-EDGTVshfIDASQE-NHRSWMTFvNCARNEQEQN 91

                         90       100
                 ....*....|....*....|....*....
gi 489914829  96 ---GRHGKRVYIVALRDIARGEELFYDYG 121
Cdd:cd19196   92 levVQIGESIYYRAIKDIPPDQELLVWYG 120
SET_SETDB2 cd10523
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) ...
 71-147 5.02e-06

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) and similar proteins; SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis.


Pssm-ID: 380921 [Multi-domain]  Cd Length: 266  Bit Score: 44.82  E-value: 5.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  71 IDGGDEGNDARWINHSCDPNCEAQE---GRHGKRVYIVAL---RDIARGEELFYDYGLVLDgriTRKLKEgYRCLCGTTP 144
Cdd:cd10523  186 LDASKEGNVGRFLNHSCCPNLFVQNvfvDTHDKNFPWVAFftnRVVKAGTELTWDYSYDAG---TSPEQE-IPCLCGVNK 261


                 ...
gi 489914829 145 CRG 147
Cdd:cd10523  262 CQK 264
SET_SETD4 cd19177
SET domain found in SET domain-containing protein 4 (SETD4) and similar proteins; SETD4 is a ...
 83-121 9.38e-06

SET domain found in SET domain-containing protein 4 (SETD4) and similar proteins; SETD4 is a cytosolic and nuclear functional lysine methyltransferase that plays a crucial role in breast carcinogenesis. However, its specific substrates and modification sites remain to be disclosed.


Pssm-ID: 380954 [Multi-domain]  Cd Length: 245  Bit Score: 44.21  E-value: 9.38e-06
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 489914829  83 INHSCDPNCEAQEGRHGKRVYIVALRDIARGEELFYDYG 121
Cdd:cd19177  192 LNHSPDVNVKAGFNKSGKCYEIRTGTDYKKGEEVFISYG 230
PR-SET_PRDM14 cd19198
PR-SET domain found in PR domain zinc finger protein 14 (PRDM14) and similar proteins; PRDM14 ...
 20-121 5.60e-05

PR-SET domain found in PR domain zinc finger protein 14 (PRDM14) and similar proteins; PRDM14 (also termed PR domain-containing protein 14) acts as a transcription factor that has both positive and negative roles on transcription. It acts on regulating epigenetic modifications in the cells, playing a key role in the regulation of cell pluripotency, epigenetic reprogramming, differentiation and development. Aberrant PRDM14 expression is associated with tumorigenesis, cell migration and cell chemotherapeutic drugs resistance.


Pssm-ID: 380975  Cd Length: 133  Bit Score: 40.84  E-value: 5.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  20 GVFATRKIPAGTRIIEYGGKRISAEEADrrhpTNPDDPFHTFFF---SLSsgRVIDG-GDEGNDARWINhsCDPNCEAQE 95
Cdd:cd19198   21 GVFCKKTIPKGTRFGPFRGRVVNTSEIK----TYDDNSFMWEIFedgKLS--HFIDGrGSTGNWMSYVN--CARYAEEQN 92

                         90       100
                 ....*....|....*....|....*....
gi 489914829  96 ---GRHGKRVYIVALRDIARGEELFYDYG 121
Cdd:cd19198   93 liaIQCQGQIFYESCKEILQGQELLVWYG 121
SET_SETD5 cd19181
SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and ...
 11-120 2.71e-04

SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins; SETD5 is a probable transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. SETD5 loss-of-function mutations are a likely cause of a familial syndromic intellectual disability with variable phenotypic expression.


Pssm-ID: 380958  Cd Length: 150  Bit Score: 39.22  E-value: 2.71e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  11 VRRSRLHGNGVFATRKIPAGTRIIEYGGKRISAEEAD-RRHPTNPDDPFhTFFFSLSSG--RVIDGGDEGNDARWINHSC 87
Cdd:cd19181   11 VTRVQKHRKILRAARDLALDTLIIEYRGKVMLRQQFEvNGHFFKRPYPF-VLFYSKFNGveMCVDARTFGNDARFIRRSC 89

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 489914829  88 DPNCEAQEGRHGKRVY--IVALRDIARGEE--LFYDY 120
Cdd:cd19181   90 TPNAEVRHMIADGMIHlcIYAVAAIAKDAEvtIAFDY 126
SET_ATXR5_6-like cd10539
SET domain found in fungal protein lysine methyltransferase SET5 and similar protein; The ...
 21-120 3.41e-04

SET domain found in fungal protein lysine methyltransferase SET5 and similar protein; The family includes Arabidopsis thaliana ATXR5 and ATXR6. Both ATXR5 (also termed protein SET DOMAIN GROUP 15, or TRX-related protein 5) and ATXR6 (also termed protein SET DOMAIN GROUP 34, or TRX-related protein 6) function as histone methyltransferase that specifically monomethylates 'Lys-37' of histone H3 (H3K27me1). They are required for chromatin structure and gene silencing.


Pssm-ID: 380937  Cd Length: 138  Bit Score: 38.55  E-value: 3.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  21 VFATRKIPAGTRIIEYGG--KRISAEEADRrhptnpDDPFHTFFFS--LSSGRVIDGGDEGNDARWI----NHS------ 86
Cdd:cd10539   18 VEADGFIKDLTIIAEYTGdvDYIRNREFDD------NDSIMTLLLAgdPSKSLVICPDKRGNIARFIsginNHTkdgkkk 91

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 489914829  87 -------CDPNCEAqegrhgkRVYIVALRDIARGEELFYDY 120
Cdd:cd10539   92 qnckcvrYSINGEA-------RVLLVATRDIAKGERLYYDY 125
PR-SET_PRDM13 cd19197
PR-SET domain found in PR domain zinc finger protein 13 (PRDM13) and similar proteins; PRDM13 ...
 27-121 3.44e-04

PR-SET domain found in PR domain zinc finger protein 13 (PRDM13) and similar proteins; PRDM13 (also termed PR domain-containing protein 13) may be involved in transcriptional regulation. It mediates the balance of inhibitory and excitatory neurons in somatosensory circuits.


Pssm-ID: 380974  Cd Length: 103  Bit Score: 38.26  E-value: 3.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  27 IPAGTRIIEYGGK-RISAEEADRRHPTNPDDPFhtfffsLSSGRVIDGGDEGNDARWIN------HSCDPNCEAQEGRHG 99
Cdd:cd19197    1 IPAGLRLGPVPGIfKLGKYLSDRKEPGNKKKVR------RVRGDYLVDESGSPATEWIGlvraarNNQEQNLEAIADLPG 74

                         90       100
                 ....*....|....*....|..
gi 489914829 100 KRVYIVALRDIARGEELFYDYG 121
Cdd:cd19197   75 GQIFYRALRDIQPGEELTVWYS 96
PR-SET_ZFPM cd19201
PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also ...
 20-117 5.78e-04

PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380978  Cd Length: 122  Bit Score: 37.71  E-value: 5.78e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  20 GVFATRKIPAGTRIIEYGGKrISAEEADRRHptnpDDPFHTFFFSLSSGRVIDGGDEGNdarWINH------SCDPNCEA 93
Cdd:cd19201   21 GVWAKQPLPEGTRFGPYPGK-LVKEPLDPSY----EWKVEAQGSKGGEGLLLLTEDSGT---WLKLvrsaddEDEANLIL 92

                         90       100
                 ....*....|....*....|....
gi 489914829  94 QegRHGKRVYIVALRDIARGEELF 117
Cdd:cd19201   93 Y--FKGGQIWCEVTKDIPPGEELI 114
SET_SMYD1 cd10526
SET domain (including post-SET domain) found in SET and MYND domain-containing protein 1 ...
 83-140 1.45e-03

SET domain (including post-SET domain) found in SET and MYND domain-containing protein 1 (SMYD1) and similar proteins; SMYD1 (EC 2.1.1.43), also termed BOP, is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD1 plays a critical role in cardiomyocyte differentiation, cardiac morphogenesis and myofibril organization, as well as in the regulation of endothelial cells (ECs). It is expressed in vascular endothelial cells, it has beenshown that knockdown of SMYD1 in endothelial cells impairs EC migration and tube formation.


Pssm-ID: 380924 [Multi-domain]  Cd Length: 210  Bit Score: 37.78  E-value: 1.45e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489914829  83 INHSCDPNCEAQEgrHGKRVYIVALRDIARGEELFYDYGLVLDGRITRK--LKEGY--RCLC 140
Cdd:cd10526  146 VNHDCWPNCTVIF--NNGRIELRALGKISEGDELTVSYIDFLNTSEDRKeqLKKQYyfDCTC 205
PR-SET_PRDM-like cd10534
PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family ...
 20-116 2.19e-03

PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family of proteins is defined based on the conserved N-terminal PR domain, which is closely related to the Su(var)3-9, enhancer of zeste, and trithorax (SET) domains of histone methyltransferases, and is specifically called PR-SET domain. The family consists of 17 members in primates. PRDMs play diverse roles in cell-cycle regulation, differentiation, and meiotic recombination. The family also contains zinc finger protein ZFPM1 and ZFPM2. ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380932  Cd Length: 83  Bit Score: 35.25  E-value: 2.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  20 GVFATRKIPAGTRiieYGgkrisaeeadrrhptnpddPFHtfffslssGRVidggdegNdarWI------NHSCDPNCEA 93
Cdd:cd10534   18 GVFARRTIPAGTR---FG-------------------PLE--------GVV-------N---WMrfvrpaRNEEEQNLVA 57

                         90       100
                 ....*....|....*....|...
gi 489914829  94 qeGRHGKRVYIVALRDIARGEEL 116
Cdd:cd10534   58 --YQHGGQIYFRTTRDIPPGEEL 78
SET_SETD9 cd10537
SET domain found in SET domain-containing protein 9 (SETD9) and similar proteins; SETD9 is an ...
 10-120 2.20e-03

SET domain found in SET domain-containing protein 9 (SETD9) and similar proteins; SETD9 is an uncharacterized protein that belongs to the class V-like SAM-binding methyltransferase superfamily.


Pssm-ID: 380935  Cd Length: 150  Bit Score: 36.40  E-value: 2.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  10 SVRRSRLH--GNGVFATR-KIPAGTRIIEYGGKRISAEEAdrRHPTNPDDPFHtffFSLSSGRVIDGgdegND---ARWI 83
Cdd:cd10537    7 HRKPSSIPdaGTGVFVEKgRVPPGTVVALYPGTVYLPYEP--ILFQSIGNPFL---FRRYDGIIIDG----NPlalGHYV 77

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489914829  84 NHSCD---PNCEAQE---------------------------GRHGKR----VYIVALRDIARGEELFYDY 120
Cdd:cd10537   78 NHPPKgtpPNVAYQEydfpedfpeelrryipnvyyspdqvfnMTRGKRplrgVVLVATRDIKDGEELFSNY 148
PR-SET_PRDM2 cd19188
PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 ...
 19-116 4.79e-03

PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 (also termed GATA-3-binding protein G3B, lysine N-methyltransferase 8, MTB-or MTE-binding protein, PR domain-containing protein 2, retinoblastoma protein-interacting zinc finger protein, or zinc finger protein RIZ) is S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. It may function as a DNA-binding transcription factor.


Pssm-ID: 380965  Cd Length: 123  Bit Score: 35.11  E-value: 4.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  19 NGVFATRKIPAGTRIIEYGGkrisaEEADRRHPTNPddpfhTFFFSLSSGRV----IDGGD--EGNDARWINHSC---DP 89
Cdd:cd19188   20 IGVWAKKSIPKGRKFGPFVG-----EKKKRSQVKNN-----VYMWEIYGPKRgwmcVDASDptKGNWLRYVNWARsgeEQ 89

                         90       100
                 ....*....|....*....|....*..
gi 489914829  90 NCEAQEgrHGKRVYIVALRDIARGEEL 116
Cdd:cd19188   90 NLFPLQ--INRAIYYKTLKPIAPGEEL 114
PR-SET_PRDM6 cd19191
PR-SET domain found in PR domain zinc finger protein 6 (PRDM6) and similar proteins; PRDM6 ...
 18-119 5.18e-03

PR-SET domain found in PR domain zinc finger protein 6 (PRDM6) and similar proteins; PRDM6 (also termed PR domain-containing protein 6) is a putative histone-lysine N-methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. It may specifically methylate 'Lys-20' of histone H4 when associated with other proteins and in vitro.


Pssm-ID: 380968  Cd Length: 128  Bit Score: 35.14  E-value: 5.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489914829  18 GNGVFATRKIPAGTRIIEYGGKRISAEEADRrhptNPDDPFHTFFFSLSSGRV---IDGGDEgNDARWINH-SCDPNCEA 93
Cdd:cd19191   16 GYGICAAQRIPQGTWIGPFEGVLVSPEKQIG----AVRNTQHLWEIYDQEGTLqhfIDGGDP-SKSSWMRYiRCARHCGE 90

                         90       100       110
                 ....*....|....*....|....*....|.
gi 489914829  94 QE---GRHGKRVYIVALRDIARGEEL--FYD 119
Cdd:cd19191   91 QNltvVQYRGCIFYRACRDIPRGTELlvWYD 121
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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