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Conserved domains on  [gi|491789187|ref|WP_005600280|]
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hypothetical protein [Actinobacillus pleuropneumoniae]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
pseT super family cl26099
polynucleotide kinase; Provisional
 1-112 7.36e-07

polynucleotide kinase; Provisional


The actual alignment was detected with superfamily member PHA02530:

Pssm-ID: 222856 [Multi-domain]  Cd Length: 300  Bit Score: 47.71  E-value: 7.36e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491789187   1 MRKLIVIRGHSGSGKSTFAKQKIAEFeqhfpsGKVFHIEHD---QFLY---ENGEYIWTKERFQSAKILAKQKLASAWEF 74
Cdd:PHA02530   1 MMKIILTVGVPGSGKSTWAREFAAKN------PKAVNVNRDdlrQSLFghgEWGEYKFTKEKEDLVTKAQEAAALAALKS 74

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 491789187  75 AKNhpqvpilIVISNVNIALQAVEKYQNIANSLRMKIE 112
Cdd:PHA02530  75 GKS-------VIISDTNLNPERRRKWKELAKELGAEFE 105
 
Name Accession Description Interval E-value
pseT PHA02530
polynucleotide kinase; Provisional
 1-112 7.36e-07

polynucleotide kinase; Provisional


Pssm-ID: 222856 [Multi-domain]  Cd Length: 300  Bit Score: 47.71  E-value: 7.36e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491789187   1 MRKLIVIRGHSGSGKSTFAKQKIAEFeqhfpsGKVFHIEHD---QFLY---ENGEYIWTKERFQSAKILAKQKLASAWEF 74
Cdd:PHA02530   1 MMKIILTVGVPGSGKSTWAREFAAKN------PKAVNVNRDdlrQSLFghgEWGEYKFTKEKEDLVTKAQEAAALAALKS 74

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 491789187  75 AKNhpqvpilIVISNVNIALQAVEKYQNIANSLRMKIE 112
Cdd:PHA02530  75 GKS-------VIISDTNLNPERRRKWKELAKELGAEFE 105
Udk COG0572
Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway ...
 2-58 9.47e-05

Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 440337 [Multi-domain]  Cd Length: 206  Bit Score: 41.36  E-value: 9.47e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 491789187   2 RKLIVIRGHSGSGKSTFAKqKIAEfeqHFPSGKVFHIEHDQFlYENGEYIWTKERFQ 58
Cdd:COG0572    7 PRIIGIAGPSGSGKTTFAR-RLAE---QLGADKVVVISLDDY-YKDREHLPLDERGK 58
ABC_UvrA cd03238
ATP-binding cassette domain of the excision repair protein UvrA; Nucleotide excision repair in ...
 2-101 2.76e-03

ATP-binding cassette domain of the excision repair protein UvrA; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep ATP-dependent reaction that requires the UvrA, UvrB, and UvrC proteins. Both UvrA and UvrB are ATPases, with UvrA having two ATP binding sites, which have the characteristic signature of the family of ABC proteins, and UvrB having one ATP binding site that is structurally related to that of helicases.


Pssm-ID: 213205 [Multi-domain]  Cd Length: 176  Bit Score: 36.92  E-value: 2.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491789187   2 RKLIVIRGHSGSGKSTFAKQ--------KIAEFEQHFPSGKVFHIEHDQFLYENG-EYIWTKERFQSAKILAKQKLASAW 72
Cdd:cd03238   21 NVLVVVTGVSGSGKSTLVNEglyasgkaRLISFLPKFSRNKLIFIDQLQFLIDVGlGYLTLGQKLSTLSGGELQRVKLAS 100

                         90       100
                 ....*....|....*....|....*....
gi 491789187  73 EFAKNHPqvPILIVISNVNIALQAVEKYQ 101
Cdd:cd03238  101 ELFSEPP--GTLFILDEPSTGLHQQDINQ 127
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 4-21 3.66e-03

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 36.13  E-value: 3.66e-03
                          10
                  ....*....|....*...
gi 491789187    4 LIVIRGHSGSGKSTFAKQ 21
Cdd:pfam13671   1 LILLVGLPGSGKSTLARR 18
 
Name Accession Description Interval E-value
pseT PHA02530
polynucleotide kinase; Provisional
 1-112 7.36e-07

polynucleotide kinase; Provisional


Pssm-ID: 222856 [Multi-domain]  Cd Length: 300  Bit Score: 47.71  E-value: 7.36e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491789187   1 MRKLIVIRGHSGSGKSTFAKQKIAEFeqhfpsGKVFHIEHD---QFLY---ENGEYIWTKERFQSAKILAKQKLASAWEF 74
Cdd:PHA02530   1 MMKIILTVGVPGSGKSTWAREFAAKN------PKAVNVNRDdlrQSLFghgEWGEYKFTKEKEDLVTKAQEAAALAALKS 74

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 491789187  75 AKNhpqvpilIVISNVNIALQAVEKYQNIANSLRMKIE 112
Cdd:PHA02530  75 GKS-------VIISDTNLNPERRRKWKELAKELGAEFE 105
Udk COG0572
Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway ...
 2-58 9.47e-05

Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 440337 [Multi-domain]  Cd Length: 206  Bit Score: 41.36  E-value: 9.47e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 491789187   2 RKLIVIRGHSGSGKSTFAKqKIAEfeqHFPSGKVFHIEHDQFlYENGEYIWTKERFQ 58
Cdd:COG0572    7 PRIIGIAGPSGSGKTTFAR-RLAE---QLGADKVVVISLDDY-YKDREHLPLDERGK 58
PRK06762 PRK06762
hypothetical protein; Provisional
 1-21 9.93e-05

hypothetical protein; Provisional


Pssm-ID: 235858  Cd Length: 166  Bit Score: 40.72  E-value: 9.93e-05
                         10        20
                 ....*....|....*....|.
gi 491789187   1 MRKLIVIRGHSGSGKSTFAKQ 21
Cdd:PRK06762   1 MTTLIIIRGNSGSGKTTIAKQ 21
COG4639 COG4639
Predicted kinase [General function prediction only];
1-21 2.06e-04

Predicted kinase [General function prediction only];


Pssm-ID: 443677 [Multi-domain]  Cd Length: 145  Bit Score: 39.43  E-value: 2.06e-04
                         10        20
                 ....*....|....*....|.
gi 491789187   1 MRKLIVIRGHSGSGKSTFAKQ 21
Cdd:COG4639    1 MLSLVVLIGLPGSGKSTFARR 21
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
4-21 8.73e-04

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 37.97  E-value: 8.73e-04
                         10
                 ....*....|....*...
gi 491789187   4 LIVIRGHSGSGKSTFAKQ 21
Cdd:COG0645    1 LILVCGLPGSGKSTLARA 18
Kti12 COG4088
tRNA uridine 5-carbamoylmethylation protein Kti12 (Killer toxin insensitivity protein) ...
 4-43 1.35e-03

tRNA uridine 5-carbamoylmethylation protein Kti12 (Killer toxin insensitivity protein) [Translation, ribosomal structure and biogenesis, Defense mechanisms];


Pssm-ID: 443264 [Multi-domain]  Cd Length: 179  Bit Score: 37.78  E-value: 1.35e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 491789187   4 LIVIRGHSGSGKSTFAKQKIAEFEQHfpSGKVFHIEHDQF 43
Cdd:COG4088    6 LLILTGPPGSGKTTFAKALAQRLYAE--GIAVALLHSDDF 43
ABC_UvrA cd03238
ATP-binding cassette domain of the excision repair protein UvrA; Nucleotide excision repair in ...
 2-101 2.76e-03

ATP-binding cassette domain of the excision repair protein UvrA; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep ATP-dependent reaction that requires the UvrA, UvrB, and UvrC proteins. Both UvrA and UvrB are ATPases, with UvrA having two ATP binding sites, which have the characteristic signature of the family of ABC proteins, and UvrB having one ATP binding site that is structurally related to that of helicases.


Pssm-ID: 213205 [Multi-domain]  Cd Length: 176  Bit Score: 36.92  E-value: 2.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491789187   2 RKLIVIRGHSGSGKSTFAKQ--------KIAEFEQHFPSGKVFHIEHDQFLYENG-EYIWTKERFQSAKILAKQKLASAW 72
Cdd:cd03238   21 NVLVVVTGVSGSGKSTLVNEglyasgkaRLISFLPKFSRNKLIFIDQLQFLIDVGlGYLTLGQKLSTLSGGELQRVKLAS 100

                         90       100
                 ....*....|....*....|....*....
gi 491789187  73 EFAKNHPqvPILIVISNVNIALQAVEKYQ 101
Cdd:cd03238  101 ELFSEPP--GTLFILDEPSTGLHQQDINQ 127
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 4-21 3.66e-03

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 36.13  E-value: 3.66e-03
                          10
                  ....*....|....*...
gi 491789187    4 LIVIRGHSGSGKSTFAKQ 21
Cdd:pfam13671   1 LILLVGLPGSGKSTLARR 18
RNA_helicase pfam00910
RNA helicase; This family includes RNA helicases thought to be involved in duplex unwinding ...
 5-34 7.31e-03

RNA helicase; This family includes RNA helicases thought to be involved in duplex unwinding during viral RNA replication. Members of this family are found in a variety of single stranded RNA viruses.


Pssm-ID: 459992  Cd Length: 102  Bit Score: 34.50  E-value: 7.31e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 491789187    5 IVIRGHSGSGKSTFAKQKIAEFEQHFPSGK 34
Cdd:pfam00910   1 IWLYGPPGCGKSTLAKYLARALLKKLGLPK 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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