L-threonylcarbamoyladenylate synthase catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate, and is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine
tRNA A37 threonylcarbamoyladenosine synthetase subunit TsaC/SUA5/YrdC [Translation, ribosomal structure and biogenesis]; tRNA A37 threonylcarbamoyladenosine synthetase subunit TsaC/SUA5/YrdC is part of the Pathway/BioSystem: tRNA modification
:
Pssm-ID: 439780 [Multi-domain] Cd Length: 204 Bit Score: 313.57 E-value: 6.10e-108
Threonylcarbamoyl-AMP synthase, C-terminal domain; This domain can be found in the C terminus ...
201-334
2.75e-47
Threonylcarbamoyl-AMP synthase, C-terminal domain; This domain can be found in the C terminus of threonylcarbamoyl-AMP synthases, including Sua5 from Saccharomyces cerevisiae and YwlC from Bacillus subtilis. Threonylcarbamoyl-AMP synthase is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine. This domain adopts the Rossmann fold and may be involved in GTP and/or tRNA binding based on structural similarity with both GTP and tRNA binding proteins.
:
Pssm-ID: 460941 Cd Length: 134 Bit Score: 156.32 E-value: 2.75e-47
tRNA A37 threonylcarbamoyladenosine synthetase subunit TsaC/SUA5/YrdC [Translation, ribosomal structure and biogenesis]; tRNA A37 threonylcarbamoyladenosine synthetase subunit TsaC/SUA5/YrdC is part of the Pathway/BioSystem: tRNA modification
Pssm-ID: 439780 [Multi-domain] Cd Length: 204 Bit Score: 313.57 E-value: 6.10e-108
tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Has ...
7-208
2.43e-81
tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Has paralogs, but YrdC called a tRNA modification protein. Ref 2 authors say probably heteromultimeric complex. Paralogs may mean its does the final binding to the tRNA. [Protein synthesis, tRNA and rRNA base modification]
Pssm-ID: 272879 [Multi-domain] Cd Length: 201 Bit Score: 245.70 E-value: 2.43e-81
Telomere recombination; This domain has been shown to bind preferentially to dsRNA. The domain ...
21-195
1.86e-79
Telomere recombination; This domain has been shown to bind preferentially to dsRNA. The domain is found in SUA5 as well as HypF and YrdC. It has also been shown to be required for telomere recombniation in yeast.
Pssm-ID: 460153 [Multi-domain] Cd Length: 176 Bit Score: 240.11 E-value: 1.86e-79
Threonylcarbamoyl-AMP synthase, C-terminal domain; This domain can be found in the C terminus ...
201-334
2.75e-47
Threonylcarbamoyl-AMP synthase, C-terminal domain; This domain can be found in the C terminus of threonylcarbamoyl-AMP synthases, including Sua5 from Saccharomyces cerevisiae and YwlC from Bacillus subtilis. Threonylcarbamoyl-AMP synthase is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine. This domain adopts the Rossmann fold and may be involved in GTP and/or tRNA binding based on structural similarity with both GTP and tRNA binding proteins.
Pssm-ID: 460941 Cd Length: 134 Bit Score: 156.32 E-value: 2.75e-47
tRNA A37 threonylcarbamoyladenosine synthetase subunit TsaC/SUA5/YrdC [Translation, ribosomal structure and biogenesis]; tRNA A37 threonylcarbamoyladenosine synthetase subunit TsaC/SUA5/YrdC is part of the Pathway/BioSystem: tRNA modification
Pssm-ID: 439780 [Multi-domain] Cd Length: 204 Bit Score: 313.57 E-value: 6.10e-108
tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Has ...
7-208
2.43e-81
tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Has paralogs, but YrdC called a tRNA modification protein. Ref 2 authors say probably heteromultimeric complex. Paralogs may mean its does the final binding to the tRNA. [Protein synthesis, tRNA and rRNA base modification]
Pssm-ID: 272879 [Multi-domain] Cd Length: 201 Bit Score: 245.70 E-value: 2.43e-81
Telomere recombination; This domain has been shown to bind preferentially to dsRNA. The domain ...
21-195
1.86e-79
Telomere recombination; This domain has been shown to bind preferentially to dsRNA. The domain is found in SUA5 as well as HypF and YrdC. It has also been shown to be required for telomere recombniation in yeast.
Pssm-ID: 460153 [Multi-domain] Cd Length: 176 Bit Score: 240.11 E-value: 1.86e-79
Threonylcarbamoyl-AMP synthase, C-terminal domain; This domain can be found in the C terminus ...
201-334
2.75e-47
Threonylcarbamoyl-AMP synthase, C-terminal domain; This domain can be found in the C terminus of threonylcarbamoyl-AMP synthases, including Sua5 from Saccharomyces cerevisiae and YwlC from Bacillus subtilis. Threonylcarbamoyl-AMP synthase is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine. This domain adopts the Rossmann fold and may be involved in GTP and/or tRNA binding based on structural similarity with both GTP and tRNA binding proteins.
Pssm-ID: 460941 Cd Length: 134 Bit Score: 156.32 E-value: 2.75e-47
Family of unknown function (DUF6674); This family of proteins is functionally uncharacterized. ...
248-314
2.89e-03
Family of unknown function (DUF6674); This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 259 and 297 amino acids in length. There are two conserved sequence motifs: AMKIP and SMN.
Pssm-ID: 466528 [Multi-domain] Cd Length: 251 Bit Score: 38.74 E-value: 2.89e-03
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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Functional characterization of the conserved domain architecture found on the query.
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if a domain or superfamily has been annotated with functional sites (conserved features),
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(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
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