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Conserved domains on  [gi|547479728|ref|WP_022097694|]
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MULTISPECIES: iron-sulfur cluster assembly scaffold protein [Clostridia]

Protein Classification

iron-sulfur cluster assembly scaffold protein( domain architecture ID 10002784)

iron-sulfur cluster assembly scaffold protein, such as Escherichia coli IscU, on which IscS assembles Fe-S clusters

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IscU COG0822
Fe-S cluster assembly scaffold protein IscU, NifU family [Posttranslational modification, ...
 38-110 3.90e-12

Fe-S cluster assembly scaffold protein IscU, NifU family [Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 440584  Cd Length: 128  Bit Score: 61.39  E-value: 3.90e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 547479728  38 DISGfTHGVGWCAPQqgaCKLTLNVKEGIIQEALVETIGCSGMTHSAAMAAEILPGLTVMEALNTDLVCDAIN 110
Cdd:COG0822   27 DGSG-EGGNPLCGDT---VTLYLKVDDGRIEDAKFEGFGCAISQASASMLTELVKGKTLEEALALTDEFGDLA 95
 
Name Accession Description Interval E-value
IscU COG0822
Fe-S cluster assembly scaffold protein IscU, NifU family [Posttranslational modification, ...
 38-110 3.90e-12

Fe-S cluster assembly scaffold protein IscU, NifU family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440584  Cd Length: 128  Bit Score: 61.39  E-value: 3.90e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 547479728  38 DISGfTHGVGWCAPQqgaCKLTLNVKEGIIQEALVETIGCSGMTHSAAMAAEILPGLTVMEALNTDLVCDAIN 110
Cdd:COG0822   27 DGSG-EGGNPLCGDT---VTLYLKVDDGRIEDAKFEGFGCAISQASASMLTELVKGKTLEEALALTDEFGDLA 95
SUF_scaf_2 TIGR01994
SUF system FeS assembly protein, NifU family; Three iron-sulfur cluster assembly systems are ...
 58-132 2.93e-03

SUF system FeS assembly protein, NifU family; Three iron-sulfur cluster assembly systems are known so far. ISC is broadly distributed while NIF tends to be associated with nitrogenase in nitrogen-fixing bacteria. The most recently described is SUF, believed to be important to maintain the function during aerobic stress of enzymes with labile Fe-S clusters. It is fairly widely distributed. This family represents one of two different proteins proposed to act as a scaffold on which the Fe-S cluster is built and from which it is transferred. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 273918  Cd Length: 137  Bit Score: 36.92  E-value: 2.93e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 547479728   58 LTLNVKEGIIQEALVETIGCSGMTHSAAMAAEILPGLTVMEALNtdlvcdaintaMRELFLQIVYGRTQSAFSEG 132
Cdd:TIGR01994  42 LTVKLEGDRIEDIAFEGEGCSISQASASMMTELIKGKTVEEALS-----------LVEAFSEMIQGQETDEDEEK 105
 
Name Accession Description Interval E-value
IscU COG0822
Fe-S cluster assembly scaffold protein IscU, NifU family [Posttranslational modification, ...
 38-110 3.90e-12

Fe-S cluster assembly scaffold protein IscU, NifU family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440584  Cd Length: 128  Bit Score: 61.39  E-value: 3.90e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 547479728  38 DISGfTHGVGWCAPQqgaCKLTLNVKEGIIQEALVETIGCSGMTHSAAMAAEILPGLTVMEALNTDLVCDAIN 110
Cdd:COG0822   27 DGSG-EGGNPLCGDT---VTLYLKVDDGRIEDAKFEGFGCAISQASASMLTELVKGKTLEEALALTDEFGDLA 95
SUF_scaf_2 TIGR01994
SUF system FeS assembly protein, NifU family; Three iron-sulfur cluster assembly systems are ...
 58-132 2.93e-03

SUF system FeS assembly protein, NifU family; Three iron-sulfur cluster assembly systems are known so far. ISC is broadly distributed while NIF tends to be associated with nitrogenase in nitrogen-fixing bacteria. The most recently described is SUF, believed to be important to maintain the function during aerobic stress of enzymes with labile Fe-S clusters. It is fairly widely distributed. This family represents one of two different proteins proposed to act as a scaffold on which the Fe-S cluster is built and from which it is transferred. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 273918  Cd Length: 137  Bit Score: 36.92  E-value: 2.93e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 547479728   58 LTLNVKEGIIQEALVETIGCSGMTHSAAMAAEILPGLTVMEALNtdlvcdaintaMRELFLQIVYGRTQSAFSEG 132
Cdd:TIGR01994  42 LTVKLEGDRIEDIAFEGEGCSISQASASMMTELIKGKTVEEALS-----------LVEAFSEMIQGQETDEDEEK 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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