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Conserved domains on  [gi|124803479|ref|XP_001347732|]
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WD repeat-containing protein, putative [Plasmodium falciparum 3D7]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 13236540)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

Gene Ontology:  GO:0005515
PubMed:  10322433

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 38-302 9.82e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 83.92  E-value: 9.82e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124803479  38 LKGHRNSIEGLHLLDD-ERFCTVSHDNLVSLWRLEN----KQNIVNIKFDDAILCSSYlkkNKYLCIG---RTNMNNNIn 109
Cdd:cd00200    5 LKGHTGGVTCVAFSPDgKLLATGSGDGTIKVWDLETgellRTLKGHTGPVRDVAASAD---GTYLASGssdKTIRLWDL- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124803479 110 iinmDKEEIIESYKSECNSIFCINYYDDNKI-SYGSKDGSICFLDLIKKKNIYRYEEIGDCINYCtsSFSDNcfynsnin 188
Cdd:cd00200   81 ----ETGECVRTLTGHTSYVSSVAFSPDGRIlSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSV--AFSPD-------- 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124803479 189 nnnDTILmnpnfhIFSTYKGNILFFDLRCMLPIyQNNNLHSNYsVNCIYCY--NYFLYSGASDCLIKKYDIRyidENKPL 266
Cdd:cd00200  147 ---GTFV------ASSSQDGTIKLWDLRTGKCV-ATLTGHTGE-VNSVAFSpdGEKLLSSSSDGTIKLWDLS---TGKCL 212

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 124803479 267 DIYVGHTSPIRYISFSKDFSYFTTSSDNGSIKLWSV 302
Cdd:cd00200  213 GTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDL 248
WD40 pfam00400
WD domain, G-beta repeat;
610-637 8.13e-04

WD domain, G-beta repeat;


:

Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 8.13e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 124803479  610 HKGRVTSMEWL--GDLLFSASWDQTIKCWN 637
Cdd:pfam00400  10 HTGSVTSLAFSpdGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 38-302 9.82e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 83.92  E-value: 9.82e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124803479  38 LKGHRNSIEGLHLLDD-ERFCTVSHDNLVSLWRLEN----KQNIVNIKFDDAILCSSYlkkNKYLCIG---RTNMNNNIn 109
Cdd:cd00200    5 LKGHTGGVTCVAFSPDgKLLATGSGDGTIKVWDLETgellRTLKGHTGPVRDVAASAD---GTYLASGssdKTIRLWDL- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124803479 110 iinmDKEEIIESYKSECNSIFCINYYDDNKI-SYGSKDGSICFLDLIKKKNIYRYEEIGDCINYCtsSFSDNcfynsnin 188
Cdd:cd00200   81 ----ETGECVRTLTGHTSYVSSVAFSPDGRIlSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSV--AFSPD-------- 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124803479 189 nnnDTILmnpnfhIFSTYKGNILFFDLRCMLPIyQNNNLHSNYsVNCIYCY--NYFLYSGASDCLIKKYDIRyidENKPL 266
Cdd:cd00200  147 ---GTFV------ASSSQDGTIKLWDLRTGKCV-ATLTGHTGE-VNSVAFSpdGEKLLSSSSDGTIKLWDLS---TGKCL 212

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 124803479 267 DIYVGHTSPIRYISFSKDFSYFTTSSDNGSIKLWSV 302
Cdd:cd00200  213 GTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDL 248
WD40 pfam00400
WD domain, G-beta repeat;
263-301 6.33e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 6.33e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 124803479  263 NKPLDIYVGHTSPIRYISFSKDFSYFTTSSDNGSIKLWS 301
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 264-301 8.88e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 8.88e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 124803479   264 KPLDIYVGHTSPIRYISFSKDFSYFTTSSDNGSIKLWS 301
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 COG2319
WD40 repeat [General function prediction only];
242-302 3.11e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.83  E-value: 3.11e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 124803479 242 FLYSGASDCLIKKYDIryiDENKPLDIYVGHTSPIRYISFSKDFSYFTTSSDNGSIKLWSV 302
Cdd:COG2319  344 TLASGSDDGTVRLWDL---ATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 pfam00400
WD domain, G-beta repeat;
610-637 8.13e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 8.13e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 124803479  610 HKGRVTSMEWL--GDLLFSASWDQTIKCWN 637
Cdd:pfam00400  10 HTGSVTSLAFSpdGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 610-637 8.93e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 8.93e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 124803479   610 HKGRVTSMEWL--GDLLFSASWDQTIKCWN 637
Cdd:smart00320  11 HTGPVTSVAFSpdGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 38-302 9.82e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 83.92  E-value: 9.82e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124803479  38 LKGHRNSIEGLHLLDD-ERFCTVSHDNLVSLWRLEN----KQNIVNIKFDDAILCSSYlkkNKYLCIG---RTNMNNNIn 109
Cdd:cd00200    5 LKGHTGGVTCVAFSPDgKLLATGSGDGTIKVWDLETgellRTLKGHTGPVRDVAASAD---GTYLASGssdKTIRLWDL- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124803479 110 iinmDKEEIIESYKSECNSIFCINYYDDNKI-SYGSKDGSICFLDLIKKKNIYRYEEIGDCINYCtsSFSDNcfynsnin 188
Cdd:cd00200   81 ----ETGECVRTLTGHTSYVSSVAFSPDGRIlSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSV--AFSPD-------- 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124803479 189 nnnDTILmnpnfhIFSTYKGNILFFDLRCMLPIyQNNNLHSNYsVNCIYCY--NYFLYSGASDCLIKKYDIRyidENKPL 266
Cdd:cd00200  147 ---GTFV------ASSSQDGTIKLWDLRTGKCV-ATLTGHTGE-VNSVAFSpdGEKLLSSSSDGTIKLWDLS---TGKCL 212

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 124803479 267 DIYVGHTSPIRYISFSKDFSYFTTSSDNGSIKLWSV 302
Cdd:cd00200  213 GTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDL 248
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 33-301 1.85e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 56.19  E-value: 1.85e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124803479  33 KPLWSLKGHRNSIEGLHLLDDERF-CTVSHDNLVSLWRLENKQNIVNIKF-DDAILCSSYLKKNKYlcigrtnmnnnini 110
Cdd:cd00200   84 ECVRTLTGHTSYVSSVAFSPDGRIlSSSSRDKTIKVWDVETGKCLTTLRGhTDWVNSVAFSPDGTF-------------- 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124803479 111 inmdkeeiiesyksecnsifcinyyddnkISYGSKDGSICFLDLIKKKNIYRYEEIGDCINycTSSFSDncfynsninnn 190
Cdd:cd00200  150 -----------------------------VASSSQDGTIKLWDLRTGKCVATLTGHTGEVN--SVAFSP----------- 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124803479 191 ndtilmNPNFHIFSTYKGNILFFDLRCMLPIYQNNNlHSNYSVNCIYC-YNYFLYSGASDCLIKKYDIRyidENKPLDIY 269
Cdd:cd00200  188 ------DGEKLLSSSSDGTIKLWDLSTGKCLGTLRG-HENGVNSVAFSpDGYLLASGSEDGTIRVWDLR---TGECVQTL 257

                        250       260       270
                 ....*....|....*....|....*....|..
gi 124803479 270 VGHTSPIRYISFSKDFSYFTTSSDNGSIKLWS 301
Cdd:cd00200  258 SGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 pfam00400
WD domain, G-beta repeat;
263-301 6.33e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 6.33e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 124803479  263 NKPLDIYVGHTSPIRYISFSKDFSYFTTSSDNGSIKLWS 301
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 264-301 8.88e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 8.88e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 124803479   264 KPLDIYVGHTSPIRYISFSKDFSYFTTSSDNGSIKLWS 301
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 COG2319
WD40 repeat [General function prediction only];
242-302 3.11e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.83  E-value: 3.11e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 124803479 242 FLYSGASDCLIKKYDIryiDENKPLDIYVGHTSPIRYISFSKDFSYFTTSSDNGSIKLWSV 302
Cdd:COG2319  344 TLASGSDDGTVRLWDL---ATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
242-302 1.12e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 44.90  E-value: 1.12e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 124803479 242 FLYSGASDCLIKKYDIryiDENKPLDIYVGHTSPIRYISFSKDFSYFTTSSDNGSIKLWSV 302
Cdd:COG2319  260 LLASGSADGTVRLWDL---ATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDL 317
WD40 COG2319
WD40 repeat [General function prediction only];
242-302 1.97e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 44.13  E-value: 1.97e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 124803479 242 FLYSGASDCLIKKYDIryiDENKPLDIYVGHTSPIRYISFSKDFSYFTTSSDNGSIKLWSV 302
Cdd:COG2319  218 LLASGSADGTVRLWDL---ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL 275
WD40 COG2319
WD40 repeat [General function prediction only];
242-302 2.32e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 44.13  E-value: 2.32e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 124803479 242 FLYSGASDCLIKKYDIryiDENKPLDIYVGHTSPIRYISFSKDFSYFTTSSDNGSIKLWSV 302
Cdd:COG2319  176 LLASGSDDGTVRLWDL---ATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL 233
WD40 COG2319
WD40 repeat [General function prediction only];
243-302 6.32e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.59  E-value: 6.32e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 124803479 243 LYSGASDCLIKKYDIryiDENKPLDIYVGHTSPIRYISFSKDFSYFTTSSDNGSIKLWSV 302
Cdd:COG2319   93 LASASADGTVRLWDL---ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL 149
WD40 pfam00400
WD domain, G-beta repeat;
610-637 8.13e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 8.13e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 124803479  610 HKGRVTSMEWL--GDLLFSASWDQTIKCWN 637
Cdd:pfam00400  10 HTGSVTSLAFSpdGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 610-637 8.93e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 8.93e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 124803479   610 HKGRVTSMEWL--GDLLFSASWDQTIKCWN 637
Cdd:smart00320  11 HTGPVTSVAFSpdGKYLASGSDDGTIKLWD 40
WD40 COG2319
WD40 repeat [General function prediction only];
242-302 1.07e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 41.82  E-value: 1.07e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 124803479 242 FLYSGASDCLIKKYDIryiDENKPLDIYVGHTSPIRYISFSKDFSYFTTSSDNGSIKLWSV 302
Cdd:COG2319  134 TLASGSADGTVRLWDL---ATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL 191
WD40 COG2319
WD40 repeat [General function prediction only];
242-302 3.32e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 40.28  E-value: 3.32e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 124803479 242 FLYSGASDCLIKKYDIryiDENKPLDIYVGHTSPIRYISFSKDFSYFTTSSDNGSIKLWSV 302
Cdd:COG2319  302 LLASGSDDGTVRLWDL---ATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL 359
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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