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Conserved domains on  [gi|124809263|ref|XP_001348531|]
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succinyl-CoA ligase, putative [Plasmodium falciparum 3D7]

Protein Classification

acetate--CoA ligase family protein( domain architecture ID 11437147)

acetate--CoA ligase family protein similar to ADP-forming acetate--CoA ligase that catalyzes the formation of acetate and ATP from acetyl-CoA by using ADP and phosphate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PatZN COG1042
Acyl-CoA synthetase (NDP forming) [Energy production and conversion];
34-765 0e+00

Acyl-CoA synthetase (NDP forming) [Energy production and conversion];


:

Pssm-ID: 440664 [Multi-domain]  Cd Length: 708  Bit Score: 704.58  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124809263  34 KNSLDYIFKPRSIGIIGATERKGSVGNSIVDNLIKGESNYKLYFVNSKGSKIYNRQSYKSLKDIKEDsIDLAVIAVPRNN 113
Cdd:COG1042    3 TRSLDALFRPRSVAVIGASDRPGKVGGRVLRNLLEGGFKGKIYPVNPKYDEVLGLPCYPSVADLPEP-PDLAVIAVPAET 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124809263 114 VVNVMHELKIKNVRGVVIITAGFKETGAEGLRLENEIINIGKTNNMRIIGPNCLGIIHSYHNMNASFASSDILKGHFSLL 193
Cdd:COG1042   82 VPDVVEECGEKGVKAAVVISAGFAETGEEGAALEQELLEIARRYGMRLLGPNCLGLINPATGLNATFAPVPPLPGNIALV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124809263 194 SQSGAICSAALDLSLQHNIGFSHFISVGSMCDVQFYELVEYLFYDVNTKYILLYVESIGDMNRFVAVCKKVCLYKPIILL 273
Cdd:COG1042  162 SQSGALGTAILDWAAARGIGFSHFVSLGNEADVDFADLLDYLADDPDTRVILLYLEGIRDGRRFLSAARAAARGKPVVVL 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124809263 274 KSGKTAKAAEAAISHTGSMVGNYEIFYATMKKLGVLVVDNFEELFNMCKVLNSSKYPETNEVCVVTNAGGPGVLLVDNII 353
Cdd:COG1042  242 KSGRSEAGARAAASHTGALAGSDAVYDAAFRRAGVIRVDDLEELFDAAEALARQPPPRGRRLAIVTNSGGPGVLAADALE 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124809263 354 KNDGVLSNLNDKLKNNLNSFLPDSWSKANPIDILGDASPVLYKKTIDAIIKDDQYKNIIVLLSPQSVTEPLDTANEIINL 433
Cdd:COG1042  322 DLGLELAELSEETQAALRAVLPPFASVGNPVDITGDADPERYAAALEALLADPNVDAVLVILTPTAMTDPEEVAEALIEA 401

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124809263 434 KKQAneqGRLILCNYLGGTALEESANMLNKNYIPTFVHPEHSVQNLLKLYENIKHIQGIYEEiPEGLSNSVENHYLNKLI 513
Cdd:COG1042  402 AKGS---GKPVLASWMGGDSVAEARRLLREAGIPTFRTPERAVRALAALVRYRRNQERLMET-PASEDFDPDRERARAII 477

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124809263 514 EEyyymknksdihmspkkkksidiikkAIQNKSYILNEFDSKVILQNYDIPIVQTRIFENVDDIKDY-DHFAFPCAMKIY 592
Cdd:COG1042  478 EA-------------------------ALAEGRGVLTEAEAKALLAAYGIPVVPTRLARSAEEAVAAaEEIGYPVVLKIV 532

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124809263 593 SDKITHKKDIGGVILNINNKEELIESYKKIYNNVKAHSLEKYFKGVTIQDMVniNDGIEVILGYYYDNNFGPVLLFGSGG 672
Cdd:COG1042  533 SPDILHKSDVGGVRLNLRDAEAVRAAFEEILARVRAARPDARIDGVLVQPMV--PGGVELIVGVKRDPVFGPVIMFGLGG 610

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124809263 673 SYVEIFKDSVLLIPPLNFSYTHHTIKNTKIYKALAGnYSRFTKCDMSKLITTIVKFSELILDlLPYINECDINPLYVCGD 752
Cdd:COG1042  611 IFVEVLKDVALRLPPLNEALAREMIRELRAAKLLRG-YRGRPPADLDALADVLVRLSQLAAD-LPEILELDINPLLVVPE 688

                        730
                 ....*....|...
gi 124809263 753 KIIALDARFTLRK 765
Cdd:COG1042  689 GVVAVDARIRLAP 701
 
Name Accession Description Interval E-value
PatZN COG1042
Acyl-CoA synthetase (NDP forming) [Energy production and conversion];
34-765 0e+00

Acyl-CoA synthetase (NDP forming) [Energy production and conversion];


Pssm-ID: 440664 [Multi-domain]  Cd Length: 708  Bit Score: 704.58  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124809263  34 KNSLDYIFKPRSIGIIGATERKGSVGNSIVDNLIKGESNYKLYFVNSKGSKIYNRQSYKSLKDIKEDsIDLAVIAVPRNN 113
Cdd:COG1042    3 TRSLDALFRPRSVAVIGASDRPGKVGGRVLRNLLEGGFKGKIYPVNPKYDEVLGLPCYPSVADLPEP-PDLAVIAVPAET 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124809263 114 VVNVMHELKIKNVRGVVIITAGFKETGAEGLRLENEIINIGKTNNMRIIGPNCLGIIHSYHNMNASFASSDILKGHFSLL 193
Cdd:COG1042   82 VPDVVEECGEKGVKAAVVISAGFAETGEEGAALEQELLEIARRYGMRLLGPNCLGLINPATGLNATFAPVPPLPGNIALV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124809263 194 SQSGAICSAALDLSLQHNIGFSHFISVGSMCDVQFYELVEYLFYDVNTKYILLYVESIGDMNRFVAVCKKVCLYKPIILL 273
Cdd:COG1042  162 SQSGALGTAILDWAAARGIGFSHFVSLGNEADVDFADLLDYLADDPDTRVILLYLEGIRDGRRFLSAARAAARGKPVVVL 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124809263 274 KSGKTAKAAEAAISHTGSMVGNYEIFYATMKKLGVLVVDNFEELFNMCKVLNSSKYPETNEVCVVTNAGGPGVLLVDNII 353
Cdd:COG1042  242 KSGRSEAGARAAASHTGALAGSDAVYDAAFRRAGVIRVDDLEELFDAAEALARQPPPRGRRLAIVTNSGGPGVLAADALE 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124809263 354 KNDGVLSNLNDKLKNNLNSFLPDSWSKANPIDILGDASPVLYKKTIDAIIKDDQYKNIIVLLSPQSVTEPLDTANEIINL 433
Cdd:COG1042  322 DLGLELAELSEETQAALRAVLPPFASVGNPVDITGDADPERYAAALEALLADPNVDAVLVILTPTAMTDPEEVAEALIEA 401

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124809263 434 KKQAneqGRLILCNYLGGTALEESANMLNKNYIPTFVHPEHSVQNLLKLYENIKHIQGIYEEiPEGLSNSVENHYLNKLI 513
Cdd:COG1042  402 AKGS---GKPVLASWMGGDSVAEARRLLREAGIPTFRTPERAVRALAALVRYRRNQERLMET-PASEDFDPDRERARAII 477

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124809263 514 EEyyymknksdihmspkkkksidiikkAIQNKSYILNEFDSKVILQNYDIPIVQTRIFENVDDIKDY-DHFAFPCAMKIY 592
Cdd:COG1042  478 EA-------------------------ALAEGRGVLTEAEAKALLAAYGIPVVPTRLARSAEEAVAAaEEIGYPVVLKIV 532

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124809263 593 SDKITHKKDIGGVILNINNKEELIESYKKIYNNVKAHSLEKYFKGVTIQDMVniNDGIEVILGYYYDNNFGPVLLFGSGG 672
Cdd:COG1042  533 SPDILHKSDVGGVRLNLRDAEAVRAAFEEILARVRAARPDARIDGVLVQPMV--PGGVELIVGVKRDPVFGPVIMFGLGG 610

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124809263 673 SYVEIFKDSVLLIPPLNFSYTHHTIKNTKIYKALAGnYSRFTKCDMSKLITTIVKFSELILDlLPYINECDINPLYVCGD 752
Cdd:COG1042  611 IFVEVLKDVALRLPPLNEALAREMIRELRAAKLLRG-YRGRPPADLDALADVLVRLSQLAAD-LPEILELDINPLLVVPE 688

                        730
                 ....*....|...
gi 124809263 753 KIIALDARFTLRK 765
Cdd:COG1042  689 GVVAVDARIRLAP 701
AcCoA-syn-alpha TIGR02717
acetyl coenzyme A synthetase (ADP forming), alpha domain; Although technically reversible, it ...
 37-484 1.45e-162

acetyl coenzyme A synthetase (ADP forming), alpha domain; Although technically reversible, it is believed that this group of ADP-dependent acetyl-CoA synthetases (ACS) act in the direction of acetate and ATP production in the organisms in which it has been characterized. In most species this protein exists as a fused alpha-beta domain polypeptide. In Pyrococcus and related species, however the domains exist as separate polypeptides. This model represents the alpha (N-terminal) domain. In Pyrococcus and related species there appears to have been the development of a paralogous family such that four other proteins are close relatives. In reference, one of these (along with its beta-domain partner) was characterized as ACS-II showing specificity for phenylacetyl-CoA. This model has been constructed to exclude these non-ACS-I paralogs. This may result in new, authentic ACS-I sequences falling below the trusted cutoff.


Pssm-ID: 131764 [Multi-domain]  Cd Length: 447  Bit Score: 484.51  E-value: 1.45e-162
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124809263   37 LDYIFKPRSIGIIGATERKGSVGNSIVDNLIKGESNYKLYFVNSKGSKIYNRQSYKSLKDIkEDSIDLAVIAVPRNNVVN 116
Cdd:TIGR02717   1 LEHLFNPKSVAVIGASRDPGKVGYAIMKNLIEGGYKGKIYPVNPKAGEILGVKAYPSVLEI-PDPVDLAVIVVPAKYVPQ 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124809263  117 VMHELKIKNVRGVVIITAGFKETGAEGLRLENEIINIGKTNNMRIIGPNCLGIIHSYHNMNASFASSDILKGHFSLLSQS 196
Cdd:TIGR02717  80 VVEECGEKGVKGAVVITAGFKEVGEEGAELEQELVEIARKYGMRLLGPNCLGIINTHIKLNATFAPTMPKKGGIAFISQS 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124809263  197 GAICSAALDLSLQHNIGFSHFISVGSMCDVQFYELVEYLFYDVNTKYILLYVESIGDMNRFVAVCKKVCLYKPIILLKSG 276
Cdd:TIGR02717 160 GALLTALLDWAEKNGVGFSYFVSLGNKADIDESDLLEYLADDPDTKVILLYLEGIKDGRKFLKTAREISKKKPIVVLKSG 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124809263  277 KTAKAAEAAISHTGSMVGNYEIFYATMKKLGVLVVDNFEELFNMCKVLNSSKYPETNEVCVVTNAGGPGVLLVDNIIKND 356
Cdd:TIGR02717 240 TSEAGAKAASSHTGALAGSDEAYDAAFKQAGVIRADSIEELFDLARLLSNQPLPKGNRVAIITNAGGPGVIATDACEENG 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124809263  357 GVLSNLNDKLKNNLNSFLPDSWSKANPIDILGDASPVLYKKTIDAIIKDDQYKNIIVLLSPQSVTEPLDTANEIINLKKQ 436
Cdd:TIGR02717 320 LELAELSEATKNKLRNILPPEASIKNPVDVLGDATPERYAKALKTVAEDENVDGVVVVLTPTAMTDPEEVAKGIIEGAKK 399

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*...
gi 124809263  437 ANEqgRLILCNYLGGTALEESANMLNKNYIPTFVHPEHSVQNLLKLYE 484
Cdd:TIGR02717 400 SNE--KPVVAGFMGGKSVDPAKRILEENGIPNYTFPERAVKALSALYR 445
ATP-grasp_5 pfam13549
ATP-grasp domain; This family includes a diverse set of enzymes that possess ATP-dependent ...
 548-763 1.87e-76

ATP-grasp domain; This family includes a diverse set of enzymes that possess ATP-dependent carboxylate-amine ligase activity.


Pssm-ID: 463918 [Multi-domain]  Cd Length: 221  Bit Score: 249.31  E-value: 1.87e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124809263  548 ILNEFDSKVILQNYDIPIVQTRIFENVDDIKDY-DHFAFPCAMKIYSDKITHKKDIGGVILNINNKEELIESYKKIYNNV 626
Cdd:pfam13549   9 VLTEPEAKALLAAYGIPVVPTRLARSPEEAVAAaEEIGYPVVLKIVSPDILHKSDVGGVRLNLRSAEAVRAAYEEILERV 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124809263  627 KAHSLEKYFKGVTIQDMVniNDGIEVILGYYYDNNFGPVLLFGSGGSYVEIFKDSVLLIPPLNFSYTHHTIKNTKIYKAL 706
Cdd:pfam13549  89 RRYRPDARIEGVLVQPMA--PGGRELIVGVTRDPQFGPVIMFGLGGIAVEVLKDVAFRLPPLNMTLAREMIRRTRAYKLL 166

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 124809263  707 AGnYSRFTKCDMSKLITTIVKFSELILDlLPYINECDINPLYVCGDKIIALDARFTL 763
Cdd:pfam13549 167 KG-YRGEPPADLDALEDVLVRVSQLVID-FPEIRELDINPLLADEDGVVALDARIRL 221
CoA_binding smart00881
CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins ...
 40-136 3.96e-18

CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.


Pssm-ID: 214881 [Multi-domain]  Cd Length: 100  Bit Score: 80.25  E-value: 3.96e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124809263    40 IFKPRSIGIIGATERKGSVGNSIVDNLIKGESNYKlYFVNSK--GSKIYNRQSYKSLKDI-KEDSIDLAVIAVPRNNVVN 116
Cdd:smart00881   2 LNPNTSVAVVGASGNLGSFGLAVMRNLLEYGTKFV-GGVYPGkvGPKVDGVPVYDSVAEApEETGVDVAVIFVPAEAAPD 80

                           90       100
                   ....*....|....*....|
gi 124809263   117 VMHELKIKNVRGVVIITAGF 136
Cdd:smart00881  81 AIDEAIEAGIKGIVVITEGI 100
 
Name Accession Description Interval E-value
PatZN COG1042
Acyl-CoA synthetase (NDP forming) [Energy production and conversion];
34-765 0e+00

Acyl-CoA synthetase (NDP forming) [Energy production and conversion];


Pssm-ID: 440664 [Multi-domain]  Cd Length: 708  Bit Score: 704.58  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124809263  34 KNSLDYIFKPRSIGIIGATERKGSVGNSIVDNLIKGESNYKLYFVNSKGSKIYNRQSYKSLKDIKEDsIDLAVIAVPRNN 113
Cdd:COG1042    3 TRSLDALFRPRSVAVIGASDRPGKVGGRVLRNLLEGGFKGKIYPVNPKYDEVLGLPCYPSVADLPEP-PDLAVIAVPAET 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124809263 114 VVNVMHELKIKNVRGVVIITAGFKETGAEGLRLENEIINIGKTNNMRIIGPNCLGIIHSYHNMNASFASSDILKGHFSLL 193
Cdd:COG1042   82 VPDVVEECGEKGVKAAVVISAGFAETGEEGAALEQELLEIARRYGMRLLGPNCLGLINPATGLNATFAPVPPLPGNIALV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124809263 194 SQSGAICSAALDLSLQHNIGFSHFISVGSMCDVQFYELVEYLFYDVNTKYILLYVESIGDMNRFVAVCKKVCLYKPIILL 273
Cdd:COG1042  162 SQSGALGTAILDWAAARGIGFSHFVSLGNEADVDFADLLDYLADDPDTRVILLYLEGIRDGRRFLSAARAAARGKPVVVL 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124809263 274 KSGKTAKAAEAAISHTGSMVGNYEIFYATMKKLGVLVVDNFEELFNMCKVLNSSKYPETNEVCVVTNAGGPGVLLVDNII 353
Cdd:COG1042  242 KSGRSEAGARAAASHTGALAGSDAVYDAAFRRAGVIRVDDLEELFDAAEALARQPPPRGRRLAIVTNSGGPGVLAADALE 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124809263 354 KNDGVLSNLNDKLKNNLNSFLPDSWSKANPIDILGDASPVLYKKTIDAIIKDDQYKNIIVLLSPQSVTEPLDTANEIINL 433
Cdd:COG1042  322 DLGLELAELSEETQAALRAVLPPFASVGNPVDITGDADPERYAAALEALLADPNVDAVLVILTPTAMTDPEEVAEALIEA 401

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124809263 434 KKQAneqGRLILCNYLGGTALEESANMLNKNYIPTFVHPEHSVQNLLKLYENIKHIQGIYEEiPEGLSNSVENHYLNKLI 513
Cdd:COG1042  402 AKGS---GKPVLASWMGGDSVAEARRLLREAGIPTFRTPERAVRALAALVRYRRNQERLMET-PASEDFDPDRERARAII 477

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124809263 514 EEyyymknksdihmspkkkksidiikkAIQNKSYILNEFDSKVILQNYDIPIVQTRIFENVDDIKDY-DHFAFPCAMKIY 592
Cdd:COG1042  478 EA-------------------------ALAEGRGVLTEAEAKALLAAYGIPVVPTRLARSAEEAVAAaEEIGYPVVLKIV 532

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124809263 593 SDKITHKKDIGGVILNINNKEELIESYKKIYNNVKAHSLEKYFKGVTIQDMVniNDGIEVILGYYYDNNFGPVLLFGSGG 672
Cdd:COG1042  533 SPDILHKSDVGGVRLNLRDAEAVRAAFEEILARVRAARPDARIDGVLVQPMV--PGGVELIVGVKRDPVFGPVIMFGLGG 610

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124809263 673 SYVEIFKDSVLLIPPLNFSYTHHTIKNTKIYKALAGnYSRFTKCDMSKLITTIVKFSELILDlLPYINECDINPLYVCGD 752
Cdd:COG1042  611 IFVEVLKDVALRLPPLNEALAREMIRELRAAKLLRG-YRGRPPADLDALADVLVRLSQLAAD-LPEILELDINPLLVVPE 688

                        730
                 ....*....|...
gi 124809263 753 KIIALDARFTLRK 765
Cdd:COG1042  689 GVVAVDARIRLAP 701
AcCoA-syn-alpha TIGR02717
acetyl coenzyme A synthetase (ADP forming), alpha domain; Although technically reversible, it ...
 37-484 1.45e-162

acetyl coenzyme A synthetase (ADP forming), alpha domain; Although technically reversible, it is believed that this group of ADP-dependent acetyl-CoA synthetases (ACS) act in the direction of acetate and ATP production in the organisms in which it has been characterized. In most species this protein exists as a fused alpha-beta domain polypeptide. In Pyrococcus and related species, however the domains exist as separate polypeptides. This model represents the alpha (N-terminal) domain. In Pyrococcus and related species there appears to have been the development of a paralogous family such that four other proteins are close relatives. In reference, one of these (along with its beta-domain partner) was characterized as ACS-II showing specificity for phenylacetyl-CoA. This model has been constructed to exclude these non-ACS-I paralogs. This may result in new, authentic ACS-I sequences falling below the trusted cutoff.


Pssm-ID: 131764 [Multi-domain]  Cd Length: 447  Bit Score: 484.51  E-value: 1.45e-162
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124809263   37 LDYIFKPRSIGIIGATERKGSVGNSIVDNLIKGESNYKLYFVNSKGSKIYNRQSYKSLKDIkEDSIDLAVIAVPRNNVVN 116
Cdd:TIGR02717   1 LEHLFNPKSVAVIGASRDPGKVGYAIMKNLIEGGYKGKIYPVNPKAGEILGVKAYPSVLEI-PDPVDLAVIVVPAKYVPQ 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124809263  117 VMHELKIKNVRGVVIITAGFKETGAEGLRLENEIINIGKTNNMRIIGPNCLGIIHSYHNMNASFASSDILKGHFSLLSQS 196
Cdd:TIGR02717  80 VVEECGEKGVKGAVVITAGFKEVGEEGAELEQELVEIARKYGMRLLGPNCLGIINTHIKLNATFAPTMPKKGGIAFISQS 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124809263  197 GAICSAALDLSLQHNIGFSHFISVGSMCDVQFYELVEYLFYDVNTKYILLYVESIGDMNRFVAVCKKVCLYKPIILLKSG 276
Cdd:TIGR02717 160 GALLTALLDWAEKNGVGFSYFVSLGNKADIDESDLLEYLADDPDTKVILLYLEGIKDGRKFLKTAREISKKKPIVVLKSG 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124809263  277 KTAKAAEAAISHTGSMVGNYEIFYATMKKLGVLVVDNFEELFNMCKVLNSSKYPETNEVCVVTNAGGPGVLLVDNIIKND 356
Cdd:TIGR02717 240 TSEAGAKAASSHTGALAGSDEAYDAAFKQAGVIRADSIEELFDLARLLSNQPLPKGNRVAIITNAGGPGVIATDACEENG 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124809263  357 GVLSNLNDKLKNNLNSFLPDSWSKANPIDILGDASPVLYKKTIDAIIKDDQYKNIIVLLSPQSVTEPLDTANEIINLKKQ 436
Cdd:TIGR02717 320 LELAELSEATKNKLRNILPPEASIKNPVDVLGDATPERYAKALKTVAEDENVDGVVVVLTPTAMTDPEEVAKGIIEGAKK 399

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*...
gi 124809263  437 ANEqgRLILCNYLGGTALEESANMLNKNYIPTFVHPEHSVQNLLKLYE 484
Cdd:TIGR02717 400 SNE--KPVVAGFMGGKSVDPAKRILEENGIPNYTFPERAVKALSALYR 445
ATP-grasp_5 pfam13549
ATP-grasp domain; This family includes a diverse set of enzymes that possess ATP-dependent ...
 548-763 1.87e-76

ATP-grasp domain; This family includes a diverse set of enzymes that possess ATP-dependent carboxylate-amine ligase activity.


Pssm-ID: 463918 [Multi-domain]  Cd Length: 221  Bit Score: 249.31  E-value: 1.87e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124809263  548 ILNEFDSKVILQNYDIPIVQTRIFENVDDIKDY-DHFAFPCAMKIYSDKITHKKDIGGVILNINNKEELIESYKKIYNNV 626
Cdd:pfam13549   9 VLTEPEAKALLAAYGIPVVPTRLARSPEEAVAAaEEIGYPVVLKIVSPDILHKSDVGGVRLNLRSAEAVRAAYEEILERV 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124809263  627 KAHSLEKYFKGVTIQDMVniNDGIEVILGYYYDNNFGPVLLFGSGGSYVEIFKDSVLLIPPLNFSYTHHTIKNTKIYKAL 706
Cdd:pfam13549  89 RRYRPDARIEGVLVQPMA--PGGRELIVGVTRDPQFGPVIMFGLGGIAVEVLKDVAFRLPPLNMTLAREMIRRTRAYKLL 166

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 124809263  707 AGnYSRFTKCDMSKLITTIVKFSELILDlLPYINECDINPLYVCGDKIIALDARFTL 763
Cdd:pfam13549 167 KG-YRGEPPADLDALEDVLVRVSQLVID-FPEIRELDINPLLADEDGVVALDARIRL 221
Succ_CoA_lig pfam13607
Succinyl-CoA ligase like flavodoxin domain; This domain contains the catalytic domain from ...
 187-324 3.42e-56

Succinyl-CoA ligase like flavodoxin domain; This domain contains the catalytic domain from Succinyl-CoA ligase alpha subunit and other related enzymes. A conserved histidine is involved in phosphoryl transfer.


Pssm-ID: 433345 [Multi-domain]  Cd Length: 138  Bit Score: 190.37  E-value: 3.42e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124809263  187 KGHFSLLSQSGAICSAALDLSLQHNIGFSHFISVGSMCDVQFYELVEYLFYDVNTKYILLYVESIGDMNRFVAVCKKVCL 266
Cdd:pfam13607   1 PGNIALVSQSGALGAALLDWARSRGIGFSKFVSLGNEADVDFADLLEYLADDPETRVILLYLEGIRDGRRFLRAARRAAR 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 124809263  267 YKPIILLKSGKTAKAAEAAISHTGSMVGNYEIFYATMKKLGVLVVDNFEELFNMCKVL 324
Cdd:pfam13607  81 RKPVVVLKAGRSEAGARAAASHTGALAGSDAVYDAAFRQAGVIRVDDLEELFDAAEAL 138
CoA_binding smart00881
CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins ...
 40-136 3.96e-18

CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.


Pssm-ID: 214881 [Multi-domain]  Cd Length: 100  Bit Score: 80.25  E-value: 3.96e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124809263    40 IFKPRSIGIIGATERKGSVGNSIVDNLIKGESNYKlYFVNSK--GSKIYNRQSYKSLKDI-KEDSIDLAVIAVPRNNVVN 116
Cdd:smart00881   2 LNPNTSVAVVGASGNLGSFGLAVMRNLLEYGTKFV-GGVYPGkvGPKVDGVPVYDSVAEApEETGVDVAVIFVPAEAAPD 80

                           90       100
                   ....*....|....*....|
gi 124809263   117 VMHELKIKNVRGVVIITAGF 136
Cdd:smart00881  81 AIDEAIEAGIKGIVVITEGI 100
CoA_binding_2 pfam13380
CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins ...
 44-171 2.50e-17

CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.


Pssm-ID: 433162 [Multi-domain]  Cd Length: 116  Bit Score: 78.73  E-value: 2.50e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124809263   44 RSIGIIGATERKGSVGNSIVDNLIkgESNYKLYFVNSKGSKIYNRQSYKSLKDIKEDsIDLAVIAVPRNNVVNVMHELKI 123
Cdd:pfam13380   1 KTIAVVGASPNPGRPGYKVARYLL--EHGYPVIPVNPKAKEILGEPVYPSLADPPEP-VDLVDVFRPPEAVPEIVEEALA 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 124809263  124 KNVRGVVIITAGFKEtgaeglrlenEIINIGKTNNMRIIGPNCLGIIH 171
Cdd:pfam13380  78 LGAKAVWLQPGIENE----------EAAAIARAAGIRVVGDRCLGVEH 115
Ligase_CoA_2 pfam19045
Ligase-CoA domain; This domain is related to pfam00549 and adopts a flavodoxin fold.
 335-469 9.94e-11

Ligase-CoA domain; This domain is related to pfam00549 and adopts a flavodoxin fold.


Pssm-ID: 408815  Cd Length: 162  Bit Score: 61.12  E-value: 9.94e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124809263  335 VCVVTNAGGPGVLLVDNIIKNDGVLSNLNDKLKNNLNSFLPDSWSKANPIDILGDASPVLYKKTIDAIIKDDQYKNIIVL 414
Cdd:pfam19045   1 VVIITGAGGSGVLLSDACVDNGLTLMAIPPDLDAAFRKFIPPFGAAGNPVDITGGEPPSTYEATIRLGLEDPRIHALILG 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 124809263  415 LSPQSVTEPLDTANEIINLKKQANEQG--RLILCNYLGGTALEESANMLNKNYIPTF 469
Cdd:pfam19045  81 YWHTIVTPPMVFAELMVRVVEEMRAKGidKPVVASLAGDVEVEEAAEYLFQHGIVAY 137
CoA_binding pfam02629
CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins ...
 41-135 3.05e-09

CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.


Pssm-ID: 396961 [Multi-domain]  Cd Length: 97  Bit Score: 54.91  E-value: 3.05e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124809263   41 FKPRSIGIIGATERKGSVGNSIVDNLIKGESNyKLYFVNSK--GSKIYNRQSYKSLKDIKED-SIDLAVIAVPRNNVVNV 117
Cdd:pfam02629   1 DKDTKVIVIGAGGLGIQGLNYHFIQMLGYGIK-MVFGVNPGkgGTEILGIPVYNSVDELEEKtGVDVAVITVPAPFAQEA 79

                          90
                  ....*....|....*...
gi 124809263  118 MHELKIKNVRGVVIITAG 135
Cdd:pfam02629  80 IDELVDAGIKGIVNITPG 97
SucD COG0074
Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Succinyl-CoA ...
 91-317 4.02e-07

Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Succinyl-CoA synthetase, alpha subunit is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 439844 [Multi-domain]  Cd Length: 288  Bit Score: 52.76  E-value: 4.02e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124809263  91 YKSLKD-IKEDSIDLAVIAVPRNNVVNVMHEL---KIKNVrgvVIITagfketgaEGLRLEN--EIINIGKTNNMRIIGP 164
Cdd:COG0074   53 FDTVAEaVEETGADASVIFVPPPFAADAILEAidaGIKLI---VCIT--------EGIPVLDmvRVKRYAKAKGTRLIGP 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124809263 165 NCLGII------------HSYHnmnasfassdilKGHFSLLSQSGAICS-AALDLSlQHNIGFSHFISVGSmcDV----Q 227
Cdd:COG0074  122 NCPGIItpgecklgimpgHIFK------------PGRVGIVSRSGTLTYeAVWQLT-QAGLGQSTCVGIGG--DPiigtS 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124809263 228 FYELVEYLFYDVNTKYILLYVESIGDM----NRFVAVCKKvclyKPIILLKSGKTAKA------AEAAISHTGsmvGNYE 297
Cdd:COG0074  187 FIDVLELFEEDPETEAIVMIGEIGGSAeeeaAEYIKENMT----KPVVAYIAGRTAPPgkrmghAGAIISGGK---GTAE 259

                        250       260
                 ....*....|....*....|
gi 124809263 298 IFYATMKKLGVLVVDNFEEL 317
Cdd:COG0074  260 SKIEALEAAGVPVAESPSEI 279
COG3919 COG3919
Predicted ATP-dependent carboligase, ATP-grasp superfamily [General function prediction only];
561-671 1.04e-03

Predicted ATP-dependent carboligase, ATP-grasp superfamily [General function prediction only];


Pssm-ID: 443124 [Multi-domain]  Cd Length: 382  Bit Score: 42.61  E-value: 1.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124809263 561 YDIPIVQTRIFENVDDIKDY-DHFAFPCAMK-IYSDKITHKKDIGGV-ILNINNKEELIESYKKIYnnvkAHSLEkyfkg 637
Cdd:COG3919  128 LGVPVPKTVVLDSADDLDALaEDLGFPVVVKpADSVGYDELSFPGKKkVFYVDDREELLALLRRIA----AAGYE----- 198

                         90       100       110
                 ....*....|....*....|....*....|....
gi 124809263 638 VTIQDMVNINDGIEVILGYYYDNNfGPVLLFGSG 671
Cdd:COG3919  199 LIVQEYIPGDDGEMRGLTAYVDRD-GEVVATFTG 231
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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