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Conserved domains on  [gi|258597886|ref|XP_001348760|]
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MORN repeat protein, putative [Plasmodium falciparum 3D7]

Protein Classification

MORN repeat-containing protein( domain architecture ID 11468649)

membrane-occupation-and-recognition-nexus (MORN) repeat-containing protein may be involved in protein-protein interactions

PubMed:  33296386|35568981

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
46-243 5.95e-31

Uncharacterized conserved protein [Function unknown];


:

Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 117.36  E-value: 5.95e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258597886  46 NGSIYKGTLKDNKLHGKGIVNFNDGSSYEGEFKNGKKEGKGKWSDGNGNSYEGEWLDDKRHGNGIYKTKDGFIFDGSFKE 125
Cdd:COG4642  100 GGGGGGGGKKGGGGGGGGVLEGDDGGGYGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPHGQGTLTYADGDRYEGEFKN 179

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258597886 126 NKRHGKATITTPDETKYICNFENDQEIGdvefffangdhaygsikdgtldnYGRYEFSNGDIYVGNFKNGLFHGKGYYKW 205
Cdd:COG4642  180 GKRHGQGTLTYANGDVYEGEFKNGQRHG-----------------------QGTYTYADGDRYEGEFKNGKRHGQGTLTY 236

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 258597886 206 NYGedyKVYEGNYFKGKRNGTGQIIHSDGRIFFGAFKD 243
Cdd:COG4642  237 ADG---DRYEGEFKNGKRHGQGTMTYADGSVYEGEWKN 271
 
Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
46-243 5.95e-31

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 117.36  E-value: 5.95e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258597886  46 NGSIYKGTLKDNKLHGKGIVNFNDGSSYEGEFKNGKKEGKGKWSDGNGNSYEGEWLDDKRHGNGIYKTKDGFIFDGSFKE 125
Cdd:COG4642  100 GGGGGGGGKKGGGGGGGGVLEGDDGGGYGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPHGQGTLTYADGDRYEGEFKN 179

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258597886 126 NKRHGKATITTPDETKYICNFENDQEIGdvefffangdhaygsikdgtldnYGRYEFSNGDIYVGNFKNGLFHGKGYYKW 205
Cdd:COG4642  180 GKRHGQGTLTYANGDVYEGEFKNGQRHG-----------------------QGTYTYADGDRYEGEFKNGKRHGQGTLTY 236

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 258597886 206 NYGedyKVYEGNYFKGKRNGTGQIIHSDGRIFFGAFKD 243
Cdd:COG4642  237 ADG---DRYEGEFKNGKRHGQGTMTYADGSVYEGEWKN 271
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 44-249 2.05e-22

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 97.98  E-value: 2.05e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258597886  44 LLNGSIYKGTLKDNKLHGKGIVNFNDGSSYEGEFKNGKKEGKGKWSDGNGNSYEGEWLDDKRHGNGIYKTKDGFIFDGSF 123
Cdd:PLN03185   5 LSNGDFYSGSLLGNVPEGPGKYLWSDGCMYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGTYTGTDGTTYKGRW 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258597886 124 KENKRHGKATITtpdetkyicnfendqeigdveffFANGDHAYGSIKDGTLDNYGRYEFSNGDIYVGNFKNGLFHGKGYY 203
Cdd:PLN03185  85 RLNLKHGLGYQR-----------------------YPNGDVFEGSWIQGLQEGPGKYTWANGNVYLGDMKGGKMSGKGTL 141

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 258597886 204 KWNYGEDykvYEGNYFKGKRNGTGQIIHSDGRIFFGAFKDDNMDGE 249
Cdd:PLN03185 142 TWVSGDS---YEGQWLDGMMHGFGVYTWSDGGCYVGTWTRGLKDGK 184
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
94-115 2.56e-03

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 34.62  E-value: 2.56e-03
                           10        20
                   ....*....|....*....|..
gi 258597886    94 NSYEGEWLDDKRHGNGIYKTKD 115
Cdd:smart00698   1 DRYEGEWRNGKRHGRGVYTYAN 22
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 96-116 9.61e-03

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 33.15  E-value: 9.61e-03
                          10        20
                  ....*....|....*....|.
gi 258597886   96 YEGEWLDDKRHGNGIYKTKDG 116
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDG 21
 
Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
46-243 5.95e-31

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 117.36  E-value: 5.95e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258597886  46 NGSIYKGTLKDNKLHGKGIVNFNDGSSYEGEFKNGKKEGKGKWSDGNGNSYEGEWLDDKRHGNGIYKTKDGFIFDGSFKE 125
Cdd:COG4642  100 GGGGGGGGKKGGGGGGGGVLEGDDGGGYGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPHGQGTLTYADGDRYEGEFKN 179

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258597886 126 NKRHGKATITTPDETKYICNFENDQEIGdvefffangdhaygsikdgtldnYGRYEFSNGDIYVGNFKNGLFHGKGYYKW 205
Cdd:COG4642  180 GKRHGQGTLTYANGDVYEGEFKNGQRHG-----------------------QGTYTYADGDRYEGEFKNGKRHGQGTLTY 236

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 258597886 206 NYGedyKVYEGNYFKGKRNGTGQIIHSDGRIFFGAFKD 243
Cdd:COG4642  237 ADG---DRYEGEFKNGKRHGQGTMTYADGSVYEGEWKN 271
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
46-249 1.12e-25

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 103.50  E-value: 1.12e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258597886  46 NGSIYKGTLKDNKLHGKGIVNFNDGSSYEGEFKNGKKEGKGKWSDGNGNSYEGEWLDDKRHGNGIYKTKDGFIFDGSFKE 125
Cdd:COG4642   77 GGGGGGGGKGDGGDGGGGEGGFGGGGGGGGGKKGGGGGGGGVLEGDDGGGYGGGTADGGRGGGGIYTFPNGDVYEGEFKN 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258597886 126 NKRHGKATITTPDETKYIcnfendqeigdvefffangdhayGSIKDGTLDNYGRYEFSNGDIYVGNFKNGLFHGKGYYKW 205
Cdd:COG4642  157 GKPHGQGTLTYADGDRYE-----------------------GEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTY 213

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 258597886 206 NYGEdykVYEGNYFKGKRNGTGQIIHSDGRIFFGAFKDDNMDGE 249
Cdd:COG4642  214 ADGD---RYEGEFKNGKRHGQGTLTYADGDRYEGEFKNGKRHGQ 254
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 44-249 2.05e-22

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 97.98  E-value: 2.05e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258597886  44 LLNGSIYKGTLKDNKLHGKGIVNFNDGSSYEGEFKNGKKEGKGKWSDGNGNSYEGEWLDDKRHGNGIYKTKDGFIFDGSF 123
Cdd:PLN03185   5 LSNGDFYSGSLLGNVPEGPGKYLWSDGCMYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGTYTGTDGTTYKGRW 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258597886 124 KENKRHGKATITtpdetkyicnfendqeigdveffFANGDHAYGSIKDGTLDNYGRYEFSNGDIYVGNFKNGLFHGKGYY 203
Cdd:PLN03185  85 RLNLKHGLGYQR-----------------------YPNGDVFEGSWIQGLQEGPGKYTWANGNVYLGDMKGGKMSGKGTL 141

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 258597886 204 KWNYGEDykvYEGNYFKGKRNGTGQIIHSDGRIFFGAFKDDNMDGE 249
Cdd:PLN03185 142 TWVSGDS---YEGQWLDGMMHGFGVYTWSDGGCYVGTWTRGLKDGK 184
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
37-249 1.59e-20

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 89.25  E-value: 1.59e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258597886  37 GEITTVTLLNGSIYKGTLKDNKLHGKGIVNFNDGSSYEGEFKNGKKEGKGKWSDGNGNSYEGEWLDDKRHGNGIYKTKDG 116
Cdd:COG4642   22 GEGGLAAAGGEGGGGLGTLPGGGGYGGGADGGGGGGGGTGVAGGGGGEGGVTAAGGGGGGGGGKGDGGDGGGGEGGFGGG 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258597886 117 FIFDGSFKENKRHGKATITTPDETKYICNFENDQEIGDVEFFFANGDHAYGSIKDGTLDNYGRYEFSNGDIYVGNFKNGL 196
Cdd:COG4642  102 GGGGGGKKGGGGGGGGVLEGDDGGGYGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGK 181

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 258597886 197 FHGKGYYKWNYGedyKVYEGNYFKGKRNGTGQIIHSDGRIFFGAFKDDNMDGE 249
Cdd:COG4642  182 RHGQGTLTYANG---DVYEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQ 231
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 46-227 3.40e-19

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 88.35  E-value: 3.40e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258597886  46 NGSIYKGTLKDNKLHGKGIVNFNDGSSYEGEFKNGKKEGKGKWSDGNGNSYEGEWLDDKRHGNGIYKTKDGFIFDGSFKE 125
Cdd:PLN03185  30 DGCMYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGTYTGTDGTTYKGRWRLNLKHGLGYQRYPNGDVFEGSWIQ 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258597886 126 NKRHGKAtittpdetKYIcnfendqeigdveffFANGDHAYGSIKDGTLDNYGRYEFSNGDIYVGNFKNGLFHGKGYYKW 205
Cdd:PLN03185 110 GLQEGPG--------KYT---------------WANGNVYLGDMKGGKMSGKGTLTWVSGDSYEGQWLDGMMHGFGVYTW 166

                        170       180
                 ....*....|....*....|..
gi 258597886 206 NygeDYKVYEGNYFKGKRNGTG 227
Cdd:PLN03185 167 S---DGGCYVGTWTRGLKDGKG 185
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 41-203 2.41e-08

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 55.22  E-value: 2.41e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258597886  41 TVTLLNGSIYKGTLKDNKLHGKGIVNFNDGSSYEGEFKNGKKEGKGKWSDGNGNSYEGEWlddkrhgngiyktkdgfifd 120
Cdd:PLN03185  71 TYTGTDGTTYKGRWRLNLKHGLGYQRYPNGDVFEGSWIQGLQEGPGKYTWANGNVYLGDM-------------------- 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258597886 121 gsfKENKRHGKATITtpdetkyicnfendqeigdveffFANGDHAYGSIKDGTLDNYGRYEFSNGDIYVGNFKNGLFHGK 200
Cdd:PLN03185 131 ---KGGKMSGKGTLT-----------------------WVSGDSYEGQWLDGMMHGFGVYTWSDGGCYVGTWTRGLKDGK 184


                 ...
gi 258597886 201 GYY 203
Cdd:PLN03185 185 GVF 187
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 178-261 4.85e-07

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 51.37  E-value: 4.85e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258597886 178 GRYEFSNGDIYVGNFKNGLFHGKGYYKWNygeDYKVYEGNYFKGKRNGTGQIIHSDGRIFFGAFKDDNMDGEILEISPQG 257
Cdd:PLN03185   1 GELVLSNGDFYSGSLLGNVPEGPGKYLWS---DGCMYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGTYTGTDG 77


                 ....
gi 258597886 258 IQTK 261
Cdd:PLN03185  78 TTYK 81
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 156-242 1.58e-06

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 49.45  E-value: 1.58e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258597886 156 EFFFANGDHAYGSIKDGTLDNYGRYEFSNGDIYVGNFKNGLFHGKGYYKWNYGedyKVYEGNYFKGKRNGTGQIIHSDGR 235
Cdd:PLN03185   2 ELVLSNGDFYSGSLLGNVPEGPGKYLWSDGCMYEGEWRRGMRHGNGKISWPSG---ATYEGEFSGGYMHGSGTYTGTDGT 78


                 ....*..
gi 258597886 236 IFFGAFK 242
Cdd:PLN03185  79 TYKGRWR 85
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
94-115 2.56e-03

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 34.62  E-value: 2.56e-03
                           10        20
                   ....*....|....*....|..
gi 258597886    94 NSYEGEWLDDKRHGNGIYKTKD 115
Cdd:smart00698   1 DRYEGEWRNGKRHGRGVYTYAN 22
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
97-249 3.74e-03

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 38.40  E-value: 3.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258597886  97 EGEWLDDKRHGNGIYKTKDGFIFDGSFKENKRHGKATITTPDETKYICNFENDQEIGDVEFFFANGDHAYGSIKDGTLDN 176
Cdd:COG4642    1 GGSVAEDGAGGGGDATALGGGGEGGLAAAGGEGGGGLGTLPGGGGYGGGADGGGGGGGGTGVAGGGGGEGGVTAAGGGGG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258597886 177 YGRYEFSNGDIYVGNFKNGLFH------------GKGYYKWNYGEDYK--------------------VYEGNYFKGKRN 224
Cdd:COG4642   81 GGGGKGDGGDGGGGEGGFGGGGgggggkkgggggGGGVLEGDDGGGYGggtadggrggggiytfpngdVYEGEFKNGKPH 160

                        170       180
                 ....*....|....*....|....*
gi 258597886 225 GTGQIIHSDGRIFFGAFKDDNMDGE 249
Cdd:COG4642  161 GQGTLTYADGDRYEGEFKNGKRHGQ 185
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 96-116 9.61e-03

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 33.15  E-value: 9.61e-03
                          10        20
                  ....*....|....*....|.
gi 258597886   96 YEGEWLDDKRHGNGIYKTKDG 116
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDG 21
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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