|
Name |
Accession |
Description |
Interval |
E-value |
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
25-1088 |
0e+00 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 1785.33 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 25 KLSKMDMKNIKENIKTMKDAYDPKEVESKWYSFWEENDYFKPKkeliEENKNNEHIKKFVIILPPPNVTGTLHIGHTLTV 104
Cdd:PTZ00419 8 KLSKDEKKNKKRNISSMAASYDPKEVESGWYEWWEKSGFFKPA----EDAKSLNSGKKFVIVLPPPNVTGYLHIGHALTG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 105 AIQDSLVRYKRMKNYLTLYIPGTDHAGIATQTVVEKMLYKKENKIRQDYGREEFVKKIYEWKDLHGNKINNQMKRIGASV 184
Cdd:PTZ00419 84 AIQDSLIRYHRMKGDETLWVPGTDHAGIATQVVVEKKLMKEENKTRHDLGREEFLKKVWEWKDKHGNNICNQLRRLGSSL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 185 DWSREYFTMNENLSNAVKEAFIKFYESGLIYRDNRLVAWCPHLKTALSDIEVNLEEIKKPTKIKIPSFDHLVEVGVLYKF 264
Cdd:PTZ00419 164 DWSREVFTMDEQRSKAVKEAFVRLYEDGLIYRDTRLVNWCCYLKTAISDIEVEFEEIEKPTKITIPGYDKKVEVGVLWHF 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 265 FYQIKDSEE-KIEIATTRIETMLGDVAVAVHPKDKRYAHLIGKEIVHPFIPNRKIIIIADD-FVDMQYGTGAVKITPAHD 342
Cdd:PTZ00419 244 AYPLEDSGQeEIVVATTRIETMLGDVAVAVHPKDERYKKLHGKELIHPFIPDRKIPIIADDeLVDMEFGTGAVKITPAHD 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 343 KNDYDMMKRHNLNYINIFTLDGHINENGGKlFQGQHRFECRFKIQEELKKLNLLSDKVPNPMSLPLCSRTNDIIEYMLIP 422
Cdd:PTZ00419 324 PNDYEIAKRHNLPFINIFTLDGKINENGGE-FAGMHRFDCRRKIEEELKEMGLLRDKVPNPMRLPRCSRSGDIVEPMLIP 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 423 QWYMNCSELAHQAIQNVKLKELEIIPPQHVNTWYYWLENVRDWCISRQLWWGHRIPAYKIVFKNDVNHntddinhnddnn 502
Cdd:PTZ00419 403 QWYVNCKDMAKRAVEAVRNGELKIIPSSHENVWYHWLENIQDWCISRQLWWGHRIPAYRVISKGPETD------------ 470
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 503 ddnnnnnnnnnnlEEQNELWVVGRSYEEGLEKAKSLVGDNKP-FELIQDEDVLDTWFSSSLVPFSSLGWPNQTEDLETFF 581
Cdd:PTZ00419 471 -------------PSDEEPWVVARSEEEALEKAKKKFGLSEEdFELEQDEDVLDTWFSSGLFPFSTLGWPDQTDDLQRFF 537
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 582 PNTILETGQDILFFWVARMVMVSLHLMKKLPFKTIYLHAMIRDSRGEKMSKSKGNVVDPLDIIDGISLNKLHEKLYEGNL 661
Cdd:PTZ00419 538 PTSLLETGSDILFFWVARMVMMSLHLTDKLPFKTVFLHAMVRDSQGEKMSKSKGNVIDPLEVIEGISLQDLNQKLYEGNL 617
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 662 PEKEIKRAIELQKKEFPKGIPECGTDALRFGLLTYLKQGRNVNLDINRIIGYRHFCNKLWNAVKFFLKTLPDNYDNYNIL 741
Cdd:PTZ00419 618 PEKEIKRAIELQKKEFPNGIPECGTDALRFGLLAYTQQGRNINLDINRVVGYRHFCNKLWNAVKFALMKLLKDFNLPNST 697
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 742 IDKPEYVEKLQWEDKWILHKLNVYIKNANDNFESYNFSEVAFASYNFWLYDLCDIYLELIKPRLntdshdnfvsglkeks 821
Cdd:PTZ00419 698 LFKPNNVESLPWEDKWILHRLNVAIKEVTEGFKEYDFSEATQATYNFWLYELCDVYLELIKPRL---------------- 761
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 822 dmnniekrevveqndnniesvntnhineiNKCDNYLDGYGANKTLHVCLDYGLRLLHPISPFITEELYQKISSEPYKFNS 901
Cdd:PTZ00419 762 -----------------------------SKQSDGERKQHAQDVLHTVLDIGLRLLHPMMPFITEELYQRLPNYLRKSES 812
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 902 ISLANYPEYINIWHNENINSEMNKFMNIVKQFRSFISTLEIPPKTKLNCFIAAKHEEDKIFIEKVRTKIEVLAKLSSLSV 981
Cdd:PTZ00419 813 ISIAKYPQPNPGWNNEALDEEMKIIMSIVKSIRSLIATLGIPNKTKPDCYVTAKDAELIELIESAENLISTLAKIGSVSV 892
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 982 INYnvedlSDDLKLQVKKCLKDIVSNQFIIYVQSSEEY-LKPLLSSMLNKNKKLQASLDSYLKKINDPNYEQKVPEQVRT 1060
Cdd:PTZ00419 893 IPP-----IEEEAEVPKGCGFDVVDNKVIIYLNLDEFIdLKKELAKLEKKLAKLQKSLESYLKKISIPNYEDKVPEDVRK 967
|
1050 1060
....*....|....*....|....*...
gi 124810112 1061 MYSEKVEELNSQILSISNIICEINECLK 1088
Cdd:PTZ00419 968 LNDEKIDELNEEIKQLEQAIEELKSLLK 995
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
39-1077 |
0e+00 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 1098.18 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 39 KTMKDAYDPKEVESKWYSFWEENDYFKPKkelIEENKnnehiKKFVIILPPPNVTGTLHIGHTLTVAIQDSLVRYKRMKN 118
Cdd:COG0525 1 MELPKTYDPKEVEAKWYQYWEENGYFKAD---PDSDK-----EPFTIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQG 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 119 YLTLYIPGTDHAGIATQTVVEKMLyKKENKIRQDYGREEFVKKIYEWKDLHGNKINNQMKRIGASVDWSREYFTMNENLS 198
Cdd:COG0525 73 YNTLWQPGTDHAGIATQAVVERQL-AEEGKSRHDLGREKFLERVWEWKEESGGTITNQLRRLGASCDWSRERFTMDEGLS 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 199 NAVKEAFIKFYESGLIYRDNRLVAWCPHLKTALSDIEVNLEEIKkptkikipsfdhlvevGVLYKFFYQIKDSEEKIEIA 278
Cdd:COG0525 152 KAVREVFVRLYEKGLIYRGKRLVNWDPKLKTALSDLEVEHEEVK----------------GHLWHIRYPLADGSGYIVVA 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 279 TTRIETMLGDVAVAVHPKDKRYAHLIGKEIVHPFIpNRKIIIIADDFVDMQYGTGAVKITPAHDKNDYDMMKRHNLNYIN 358
Cdd:COG0525 216 TTRPETMLGDTAVAVHPEDERYKHLIGKTVILPLV-GREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMIN 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 359 IFTLDGHINENGGKlFQGQHRFECRFKIQEELKKLNLLSDKVPNPMSLPLCSRTNDIIEYMLIPQWYMNCSELAHQAIQN 438
Cdd:COG0525 295 ILDEDGTINENAGK-YRGLDRFEARKAIVADLEELGLLVKVEPHKHSVGHSDRSGTVIEPYLSDQWFVKMKPLAKPAIEA 373
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 439 VKLKELEIIPPQHVNTWYYWLENVRDWCISRQLWWGHRIPAYKivfkndvnhntddinhnddnnddnnnnnnnnnnlEEQ 518
Cdd:COG0525 374 VEDGEIKFVPERWEKTYFHWMENIRDWCISRQLWWGHRIPAWY----------------------------------CPD 419
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 519 NELwVVGRSYEEGLEKAKSLvgdnkpfELIQDEDVLDTWFSSSLVPFSSLGWPNQTEDLETFFPNTILETGQDILFFWVA 598
Cdd:COG0525 420 GEV-YVARTEPEACAKAGSV-------NLTQDEDVLDTWFSSALWPFSTLGWPEKTEDLKYFYPTSVLVTGFDIIFFWVA 491
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 599 RMVMVSLHLMKKLPFKTIYLHAMIRDSRGEKMSKSKGNVVDPLDIIDgislnklheklyegnlpekeikraielqkkefp 678
Cdd:COG0525 492 RMIMMGLHFTGEVPFKDVYIHGLVRDEQGRKMSKSKGNVIDPLDLID--------------------------------- 538
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 679 kgipECGTDALRFGLLTYLKQGRNVNLDINRIIGYRHFCNKLWNAVKFFLKtlpdNYDNYNILIDKPEyvEKLQWEDKWI 758
Cdd:COG0525 539 ----KYGADALRFTLAALASPGRDIKFDEERVEGYRNFANKLWNASRFVLM----NLEGFDPGLDPDP--EELSLADRWI 608
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 759 LHKLNVYIKNANDNFESYNFSEVAFASYNF-WlYDLCDIYLELIKPRLNTDshdnfvsglkeksdmNNIEKREVVeqndn 837
Cdd:COG0525 609 LSRLNKTIAEVTEALEKYRFDEAAQALYDFvW-NEFCDWYLELAKPRLYGG---------------DEAAKRETR----- 667
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 838 niesvntnhineinkcdnyldgyganKTLHVCLDYGLRLLHPISPFITEELYQKISSEPyKFNSISLANYPEYINIWHNE 917
Cdd:COG0525 668 --------------------------ATLVYVLEQILRLLHPFMPFITEEIWQKLPPRK-EGESIMLAPWPEADEELIDE 720
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 918 NINSEMNKFMNIVKQFRSFISTLEIPPKTKLNCFIAAKHEEDKIFIEKVRTKIEVLAKLSSLSVINYNVedlsddlklqV 997
Cdd:COG0525 721 EAEAEFEWLKEVISAIRNIRAEMNIPPSKKLPLLLKGADEADRARLEENAAYIKRLARLEEITILVDEK----------P 790
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 998 KKCLKDIVSNqFIIYVqsseeylkPLLSSM--------LNKN-KKLQASLDSYLKKINDPNYEQKVPEQV-------RTM 1061
Cdd:COG0525 791 EGAASAVVGG-AEVFL--------PLEGLIdveaerarLEKElAKLEKEIARVEKKLSNEGFVAKAPAEVvekerekLAE 861
|
1050
....*....|....*.
gi 124810112 1062 YSEKVEELNSQILSIS 1077
Cdd:COG0525 862 AEAKLEKLEEQLARLK 877
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
39-1078 |
0e+00 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 1078.20 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 39 KTMKDAYDPKEVESKWYSFWEENDYFKPkkelieenkNNEHIKKFVIILPPPNVTGTLHIGHTLTVAIQDSLVRYKRMKN 118
Cdd:PRK05729 3 MELPKTYDPKEVEAKWYQKWEEKGYFKP---------DDNSKKPFSIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQG 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 119 YLTLYIPGTDHAGIATQTVVEKMLyKKENKIRQDYGREEFVKKIYEWKDLHGNKINNQMKRIGASVDWSREYFTMNENLS 198
Cdd:PRK05729 74 YNTLWLPGTDHAGIATQMVVERQL-AAEGKSRHDLGREKFLEKVWEWKEESGGTITNQLRRLGASCDWSRERFTMDEGLS 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 199 NAVKEAFIKFYESGLIYRDNRLVAWCPHLKTALSDIEVNLEEIKkptkikipsfdhlvevGVLYKFFYQIKDSEEKIEIA 278
Cdd:PRK05729 153 KAVREVFVRLYEKGLIYRGKRLVNWDPKLQTALSDLEVEYKEVK----------------GKLWHIRYPLADGSDYLVVA 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 279 TTRIETMLGDVAVAVHPKDKRYAHLIGKEIVHPFIpNRKIIIIADDFVDMQYGTGAVKITPAHDKNDYDMMKRHNLNYIN 358
Cdd:PRK05729 217 TTRPETMLGDTAVAVNPEDERYKHLIGKTVILPLV-GREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMIN 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 359 IFTLDGHINENGGKlFQGQHRFECRFKIQEELKKLNLLSDKVPNPMSLPLCSRTNDIIEYMLIPQWYMNCSELAHQAIQN 438
Cdd:PRK05729 296 IMDEDGTINENPGE-YQGLDRFEARKAIVADLEELGLLVKIEPHTHSVGHSDRSGVVIEPYLSDQWFVKMKPLAKPALEA 374
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 439 VKLKELEIIPPQHVNTWYYWLENVRDWCISRQLWWGHRIPAYkivFKNDVNhntddinhnddnnddnnnnnnnnnnleeq 518
Cdd:PRK05729 375 VENGEIKFVPERWEKTYFHWMENIQDWCISRQLWWGHRIPAW---YDEDGE----------------------------- 422
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 519 nelWVVGRSYEEGLEKAKslvgdnkpfeLIQDEDVLDTWFSSSLVPFSSLGWPNQTEDLETFFPNTILETGQDILFFWVA 598
Cdd:PRK05729 423 ---VYVGREEPEAREKAL----------LTQDEDVLDTWFSSALWPFSTLGWPEKTEDLKRFYPTSVLVTGFDIIFFWVA 489
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 599 RMVMVSLHLMKKLPFKTIYLHAMIRDSRGEKMSKSKGNVVDPLDIIDgislnklheklyegnlpekeikraielqkkEFp 678
Cdd:PRK05729 490 RMIMMGLHFTGQVPFKDVYIHGLVRDEQGRKMSKSKGNVIDPLDLID------------------------------KY- 538
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 679 kgipecGTDALRFGLLTYLKQGRNVNLDINRIIGYRHFCNKLWNAVKFFLKTLPDNYDnyniliDKPEYVEKLQWEDKWI 758
Cdd:PRK05729 539 ------GADALRFTLAALASPGRDIRFDEERVEGYRNFANKLWNASRFVLMNLEGADV------GELPDPEELSLADRWI 606
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 759 LHKLNVYIKNANDNFESYNFSEVAFASYNFWLYDLCDIYLELIKPRLNTDshdnfvsglkeksdmnniEKREvveqndnn 838
Cdd:PRK05729 607 LSRLNRTVAEVTEALDKYRFDEAARALYEFIWNEFCDWYLELAKPVLQEA------------------AKRA-------- 660
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 839 iesvntnhineinkcdnyldgygANKTLHVCLDYGLRLLHPISPFITEELYQKISSEPYKFnSISLANYPEYINIWhNEN 918
Cdd:PRK05729 661 -----------------------TRATLAYVLEQILRLLHPFMPFITEELWQKLAPLGIEE-SIMLAPWPEADEAI-DEA 715
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 919 INSEMNKFMNIVKQFRSFISTLEIPPKTKLNCFIAAKHEEDKIFIEKVRTKIEVLAKLSSLSVINYNVEDlsddlklqVK 998
Cdd:PRK05729 716 AEAEFEWLKELITAIRNIRAEMNIPPSKKLPLLLKGADAEDRARLEANEAYIKRLARLESLEILADDEEA--------PE 787
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 999 KCLKDIVSNqFIIYVQsseeylkplLSSMLNKNK----------KLQASLDSYLKKINDPNYEQKVPEQV-------RTM 1061
Cdd:PRK05729 788 GAASAVVGG-AELFLP---------LEGLIDVEAelarlekelaKLEKEIERVEKKLSNEGFVAKAPEEVvekerekLAE 857
|
1050
....*....|....*..
gi 124810112 1062 YSEKVEELNSQILSISN 1078
Cdd:PRK05729 858 YEEKLAKLKERLARLKA 874
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
41-1073 |
0e+00 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 951.26 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 41 MKDAYDPKEVESKWYSFWEENDYFKPKKelieenknNEHIKKFVIILPPPNVTGTLHIGHTLTVAIQDSLVRYKRMKNYL 120
Cdd:PLN02381 96 MAKQYSPSAVEKSWYAWWEKSGYFGADA--------KSSKPPFVIVLPPPNVTGALHIGHALTAAIEDTIIRWKRMSGYN 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 121 TLYIPGTDHAGIATQTVVEKMLYKKENKIRQDYGREEFVKKIYEWKDLHGNKINNQMKRIGASVDWSREYFTMNENLSNA 200
Cdd:PLN02381 168 ALWVPGVDHAGIATQVVVEKKLMRERHLTRHDIGREEFVSEVWKWKDEYGGTILNQLRRLGASLDWSRECFTMDEQRSKA 247
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 201 VKEAFIKFYESGLIYRDNRLVAWCPHLKTALSDIEVNLEEIKKPTKIKIPSFDHLVEVGVLYKFFYQIKDSEEKIEIATT 280
Cdd:PLN02381 248 VTEAFVRLYKEGLIYRDIRLVNWDCTLRTAISDVEVDYIDIKERTLLKVPGYDKPVEFGVLTSFAYPLEGGLGEIVVATT 327
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 281 RIETMLGDVAVAVHPKDKRYAHLIGKEIVHPFiPNRKIIIIAD-DFVDMQYGTGAVKITPAHDKNDYDMMKRHNLNYINI 359
Cdd:PLN02381 328 RIETMLGDTAIAIHPDDERYKHLHGKFAVHPF-NGRKLPIICDaILVDPNFGTGAVKITPAHDPNDFEVGKRHNLEFINI 406
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 360 FTLDGHINENGGKLFQGQHRFECRFKIQEELKKLNLLSDKVPNPMSLPLCSRTNDIIEYMLIPQWYMNCSELAHQAIQNV 439
Cdd:PLN02381 407 FTDDGKINSNGGSEFAGMPRFAAREAVIEALQKKGLYRGAKNNEMRLGLCSRTNDVVEPMIKPQWFVNCSSMAKQALDAA 486
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 440 ---KLKELEIIPPQHVNTWYYWLENVRDWCISRQLWWGHRIPAYKIVFKNDvnhntddinhnddnnddnnnnnnNNNNLE 516
Cdd:PLN02381 487 idgENKKLEFIPKQYLAEWKRWLENIRDWCISRQLWWGHRIPAWYVTLEDD-----------------------QLKELG 543
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 517 EQNELWVVGRSYEEGLEKAkSLVGDNKPFELIQDEDVLDTWFSSSLVPFSSLGWPNQTEDLETFFPNTILETGQDILFFW 596
Cdd:PLN02381 544 SYNDHWVVARNESDALLEA-SQKFPGKKFELSQDPDVLDTWFSSGLFPLSVLGWPDDTDDLKAFYPTSVLETGHDILFFW 622
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 597 VARMVMVSLHLMKKLPFKTIYLHAMIRDSRGEKMSKSKGNVVDPLDIIDGISLNKLHEKLYEGNLPEKEIKRAIELQKKE 676
Cdd:PLN02381 623 VARMVMMGMQLGGDVPFRKVYLHPMIRDAHGRKMSKSLGNVIDPLEVINGISLEGLHKRLEEGNLDPKELVVAKEGQKKD 702
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 677 FPKGIPECGTDALRFGLLTYLKQGRNVNLDINRIIGYRHFCNKLWNAVKFFLKTLPDNYDNYNILidkpeYVEKLQWEDK 756
Cdd:PLN02381 703 FPNGIAECGTDALRFALVSYTAQSDKINLDILRVVGYRQWCNKLWNAVRFAMSKLGDDYTPPATL-----SVETMPFSCK 777
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 757 WILHKLNVYIKNANDNFESYNFSEVAFASYNFWLYDLCDIYLELIKPRLNTDSHDnFVSglkEKSdmnniekrevveqnd 836
Cdd:PLN02381 778 WILSVLNKAISKTVSSLDAYEFSDAASTVYSWWQYQFCDVFIEAIKPYFAGDNPE-FAS---ERA--------------- 838
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 837 nniesvntnhineinkcdnyldgyGANKTLHVCLDYGLRLLHPISPFITEELYQKISS--EPYKFNSISLANYPEYINIW 914
Cdd:PLN02381 839 ------------------------AAQDTLWICLDTGLRLLHPFMPFVTEELWQRLPQpkDHTRKDSIMISEYPSAVEAW 894
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 915 HNENINSEMNKFMNIVKQFRSFIStlEIPPKTK---LNCFIAAKHEEDKIFIEKVRTKIEVLAKLSSLSVINYNVEDLSD 991
Cdd:PLN02381 895 TNEKVEYEMDLVLSTVKCLRSLRA--EVLEKQKnerLPAFALCRNQEIAAIIKSHQLEILTLANLSSLKVLLSENDAPPA 972
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 992 DlklqvkkCLKDIVSNQFIIYVQSSEEY-LKPLLSSMLNKNKKLQASLDSYLKKINDPNYEQKVPEQVRTMYSEKVEELN 1070
Cdd:PLN02381 973 G-------CAFENVNENLKVYLQAQGAVnAEAELEKLRNKMDEIQKQQEKLEKKMNASGYKEKVPANIQEEDARKLTKLL 1045
|
...
gi 124810112 1071 SQI 1073
Cdd:PLN02381 1046 QEL 1048
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
41-1058 |
0e+00 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 882.86 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 41 MKDAYDPKEVESKWYSFWEENDYFKPkkeliEENKNNEHikkFVIILPPPNVTGTLHIGHTLTVAIQDSLVRYKRMKNYL 120
Cdd:TIGR00422 1 MPKDYDPHEVEKKWYKKWEKSGFFKP-----DGNSNKPP---FCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYN 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 121 TLYIPGTDHAGIATQTVVEKmLYKKENKIRQDYGREEFVKKIYEWKDLHGNKINNQMKRIGASVDWSREYFTMNENLSNA 200
Cdd:TIGR00422 73 VLWLPGTDHAGIATQVKVEK-KLGAEGKTKHDLGREEFREKIWEWKEESGGTIKNQIKRLGASLDWSRERFTMDEGLSKA 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 201 VKEAFIKFYESGLIYRDNRLVAWCPHLKTALSDIEVNLEEIKkptkikipsfdhlvevGVLYKFFYQIKD-SEEKIEIAT 279
Cdd:TIGR00422 152 VKEAFVRLYEKGLIYRGEYLVNWDPKLNTAISDIEVEYKEVK----------------GKLYYIRYPLANgSKDYLVVAT 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 280 TRIETMLGDVAVAVHPKDKRYAHLIGKEIVHPFIpNRKIIIIADDFVDMQYGTGAVKITPAHDKNDYDMMKRHNLNYINI 359
Cdd:TIGR00422 216 TRPETMFGDTAVAVHPEDERYKHLIGKKVILPLT-GRKIPIIADEYVDMEFGTGAVKVTPAHDFNDYEWGKRHNLEFINI 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 360 FTLDGHINENGGKlFQGQHRFECRFKIQEELKKLNLLSDKVPNPMSLPLCSRTNDIIEYMLIPQWYMNCSELAHQAIQNV 439
Cdd:TIGR00422 295 LDEDGLLNENAGK-YQGLTRFEARKKIVEDLKEEGLLVKIEPHTHNVGTCWRSGTVVEPLLSKQWFVKVEKLADKALEAA 373
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 440 KLKELEIIPPQHVNTWYYWLENVRDWCISRQLWWGHRIPAYKIVfkndvnhntddinhnddnnddnnnnnnnnnnleEQN 519
Cdd:TIGR00422 374 EEGEIKFVPKRMEKRYLNWLRNIKDWCISRQLIWGHRIPVWYCK---------------------------------ECG 420
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 520 ELWVvgrSYEEGLEKAKSLVGDNKpfELIQDEDVLDTWFSSSLVPFSSLGWPNQTEDLETFFPNTILETGQDILFFWVAR 599
Cdd:TIGR00422 421 EVYV---AKEEPLPDDKTNTGPSV--ELEQDTDVLDTWFSSSLWPFSTLGWPDETKDLKKFYPTDLLVTGYDIIFFWVAR 495
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 600 MVMVSLHLMKKLPFKTIYLHAMIRDSRGEKMSKSKGNVVDPLDIIDgislnklheklyegnlpekeikraielqkkefpk 679
Cdd:TIGR00422 496 MIFRSLALTGQVPFKEVYIHGLVRDEQGRKMSKSLGNVIDPLDVIE---------------------------------- 541
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 680 gipECGTDALRFGLLTYLKQGRNVNLDINRIIGYRHFCNKLWNAVKFFLKTLPDNYDnynilIDKPEyvEKLQWEDKWIL 759
Cdd:TIGR00422 542 ---KYGADALRFTLASLVTPGDDINFDWKRVESARNFLNKLWNASRFVLMNLSDDLE-----LSGGE--EKLSLADRWIL 611
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 760 HKLNVYIKNANDNFESYNFSEVAFASYNFWLYDLCDIYLELIKPRLNTDshdnfvsglkeksdmNNIEKREvveqndnni 839
Cdd:TIGR00422 612 SKLNRTIKEVRKALDKYRFAEAAKALYEFIWNDFCDWYIELVKYRLYNG---------------NEAEKKA--------- 667
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 840 esvntnhineinkcdnyldgygANKTLHVCLDYGLRLLHPISPFITEELYQKISSepyKFNSISLANYPEYINIWHNENI 919
Cdd:TIGR00422 668 ----------------------ARDTLYYVLDKALRLLHPFMPFITEEIWQHFKE---GADSIMLQSYPVVDAEFVDEEA 722
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 920 NSEMNKFMNIVKQFRSFISTLEIPPKTKLncFIAAKHEEDKI--FIEKVRTKIEVLAKLSSLSVINynvedlsdDLKLQV 997
Cdd:TIGR00422 723 EKAFELLKEIIVSIRNLKAESNIPPNAPL--KVLLIYTEAETaeRLKLNAVDIKGAINFSEVEVVI--------EKPEVT 792
|
970 980 990 1000 1010 1020
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 124810112 998 KKCLKDIVSNQFIIYVQSSEEyLKPLLSSMLNKNKKLQASLDSYLKKINDPNYEQKVPEQV 1058
Cdd:TIGR00422 793 EAVVELVPGFEIIIPVKGLIN-KAKELARLQKQLDKEKKEVIRIEGKLENEGFVKKAPKEV 852
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
29-1069 |
0e+00 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 757.99 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 29 MDMKNIKEniktMKDAYDPKEVESKWYSFWEENDYFKpkkelieenkNNEHIKK---FVIILPPPNVTGTLHIGHTLTVA 105
Cdd:PRK14900 7 IENENRTE----LAKGYEHREVEARWYPFWQERGYFH----------GDEHDRTrppFSIVLPPPNVTGSLHLGHALTAT 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 106 IQDSLVRYKRMKNYLTLYIPGTDHAGIATQTVVEKMLYKKENKIRQDYGREEFVKKIYEWKDLHGNKINNQMKRIGASVD 185
Cdd:PRK14900 73 LQDVLIRWKRMSGFNTLWLPGTDHAGIATQMIVEKELKKTEKKSRHDLGREAFLERVWAWKEQYGSRIGEQHKALGASLD 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 186 WSREYFTMNENLSNAVKEAFIKFYESGLIYRDNRLVAWCPHLKTALSDIEVNLEEIKKptkikipsfdhlvevGVLYKFF 265
Cdd:PRK14900 153 WQRERFTMDEGLSRAVREVFVRLHEEGLIYREKKLINWCPDCRTALSDLEVEHEEAHQ---------------GELWSFA 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 266 YQIKDSEEKIEIATTRIETMLGDVAVAVHPKDKRYAHLIGKEIVHPfIPNRKIIIIAD-DFVDMQYGTGAVKITPAHDKN 344
Cdd:PRK14900 218 YPLADGSGEIVVATTRPETMLGDTAVAVHPLDPRYMALHGKKVRHP-ITGRTFPIVADaILVDPKFGTGAVKVTPAHDFN 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 345 DYDMMKRHNLNYINIFTLDGHINENGGKLfQGQHRFECRFKIQEELKKLNLLSDKVPNPMSLPLCSRTNDIIEYMLIPQW 424
Cdd:PRK14900 297 DFEVGKRHGLEMITVIGPDGRMTAEAGPL-AGLDRFEARKEVKRLLAEQGLDRGAKPHVLPLGRCQRSATILEPLLSDQW 375
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 425 YMNCSELAHQAIQNVKLKELEIIPPQHVNTWYYWLENVRDWCISRQLWWGHRIPAYkivFKNDvNHNtddinhnddnndd 504
Cdd:PRK14900 376 YVRIEPLARPAIEAVEQGRTRFIPEQWTNTYMAWMRNIHDWCISRQLWWGHQIPAW---YCPD-GHV------------- 438
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 505 nnnnnnnnnnleeqnelwVVGRSYEEGLEKAKSLvgdnkpfELIQDEDVLDTWFSSSLVPFSSLGWPNQTEDLETFFPNT 584
Cdd:PRK14900 439 ------------------TVARETPEACSTCGKA-------ELRQDEDVLDTWFSSGLWPFSTMGWPEQTDTLRTFYPTS 493
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 585 ILETGQDILFFWVARMVMVSLHLMKKLPFKTIYLHAMIRDSRGEKMSKSKGNVVDPLDIidgislnklheklyegnlpek 664
Cdd:PRK14900 494 VMETGHDIIFFWVARMMMMGLHFMGEVPFRTVYLHPMVRDEKGQKMSKTKGNVIDPLVI--------------------- 552
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 665 eikraielqkkefpkgIPECGTDALRFGLLTYLKQGRNVNLDINRIIGYRHFCNKLWNAVKFFLKTLPDNYDNYNILIDK 744
Cdd:PRK14900 553 ----------------TEQYGADALRFTLAALTAQGRDIKLAKERIEGYRAFANKLWNASRFALMNLSGYQERGEDPARL 616
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 745 PeyvekLQWEDKWILHKLNVYIKNANDNFESYNFSEVAFASYNFWLYDLCDIYLELIKPRLNTDshdnfvsglkeksdmn 824
Cdd:PRK14900 617 A-----RTPADRWILARLQRAVNETVEALEAFRFNDAANAVYAFVWHELCDWYIELAKEALASE---------------- 675
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 825 NIEKREvveqndnniesvntnhineinkcdnyldgyGANKTLHVCLDYGLRLLHPISPFITEELYQKIS---SEPYKFNS 901
Cdd:PRK14900 676 DPEARR------------------------------SVQAVLVHCLQTSYRLLHPFMPFITEELWHVLRaqvGASAWADS 725
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 902 ISLANYPEYINIwhNENINSEMNKFMNIVKQFRSFISTLEIPPKTKLNcfiaakhEEDKIFIEKVRTKIEVLAKLSSLSV 981
Cdd:PRK14900 726 VLAAEYPRKGEA--DEAAEAAFRPVLGIIDAVRNIRGEMGIPWKVKLG-------AQAPVEIAVADPALRDLLQAGELAR 796
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 982 InYNVEDLSDdlkLQVKKCLKDIVSNQFIIYVQSSEEYLKPLL--------SSMLNKN-KKLQASLDSYLKKINDPNYEQ 1052
Cdd:PRK14900 797 V-HRVAGVEG---SRLVVAAATAPAPQSAVGVGPGFEVRVPLAgvidlaaeTARVDKEiGKVDQDLAVLERKLQNPSFVQ 872
|
1050
....*....|....*..
gi 124810112 1053 KVPEQVRTMYSEKVEEL 1069
Cdd:PRK14900 873 NAPPAVVEKDRARAEEL 889
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
51-1078 |
0e+00 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 701.70 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 51 ESKWYSFWEENDYFKPKKELIEEnknnehikKFVIILPPPNVTGTLHIGHTLTVAIQDSLVRYKRMKNYLTLYIPGTDHA 130
Cdd:PLN02943 66 EERIYNWWESQGYFKPNFDRGGD--------PFVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHA 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 131 GIATQTVVEKMLYKKENKiRQDYGREEFVKKIYEWKDLHGNKINNQMKRIGASVDWSREYFTMNENLSNAVKEAFIKFYE 210
Cdd:PLN02943 138 GIATQLVVEKMLASEGIK-RTDLGRDEFTKRVWEWKEKYGGTITNQIKRLGASCDWSRERFTLDEQLSRAVVEAFVRLHE 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 211 SGLIYRDNRLVAWCPHLKTALSDIEVNLEEikkptkikipsfdhlvEVGVLYKFFYQIK-DSEEKIEIATTRIETMLGDV 289
Cdd:PLN02943 217 KGLIYQGSYMVNWSPNLQTAVSDLEVEYSE----------------EPGTLYYIKYRVAgGSEDFLTIATTRPETLFGDV 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 290 AVAVHPKDKRYAHLIGKEIVHPFIPNRKIIIIADDFVDMQYGTGAVKITPAHDKNDYDMMKRHNLNYINIFTLDGHINEN 369
Cdd:PLN02943 281 AIAVNPEDDRYSKYIGKMAIVPMTYGRHVPIIADRYVDKDFGTGVLKISPGHDHNDYLLARKLGLPILNVMNKDGTLNEV 360
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 370 GgklfqGQHRFECRFKIQEELKKLNLLSDKVPNPMSLPLCSRTNDIIEYMLIPQWYMNCSELAHQAIQNVKLKELEIIPP 449
Cdd:PLN02943 361 A-----GLYWFEAREKLWSDLEETGLAVKKEPHTLRVPRSQRGGEVIEPLVSKQWFVTMEPLAEKALKAVENGELTIIPE 435
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 450 QHVNTWYYWLENVRDWCISRQLWWGHRIPAYKIVFKNdvnhntddinhnddnnddnnnnnnnnnnLEEQnelWVVGRSYE 529
Cdd:PLN02943 436 RFEKIYNHWLSNIKDWCISRQLWWGHRIPVWYIVGKD----------------------------CEED---YIVARSAE 484
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 530 EGLEKAKSLVGdnKPFELIQDEDVLDTWFSSSLVPFSSLGWPN-QTEDLETFFPNTILETGQDILFFWVARMVMVSLHLM 608
Cdd:PLN02943 485 EALEKAREKYG--KDVEIYQDPDVLDTWFSSALWPFSTLGWPDvSAEDFKKFYPTTVLETGHDILFFWVARMVMMGIEFT 562
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 609 KKLPFKTIYLHAMIRDSRGEKMSKSKGNVVDPLDIIdgislnklheklyegnlpekeikraielqkKEFpkgipecGTDA 688
Cdd:PLN02943 563 GTVPFSYVYLHGLIRDSQGRKMSKTLGNVIDPLDTI------------------------------KEF-------GTDA 605
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 689 LRFGLLTYlKQGRNVNLDINRIIGYRHFCNKLWNAVKFFLKTLPDNYDNY---NIL---IDKPEYVEKLQWEDKWILHKL 762
Cdd:PLN02943 606 LRFTLALG-TAGQDLNLSTERLTSNKAFTNKLWNAGKFVLQNLPSQSDTSaweHILackFDKEESLLSLPLPECWVVSKL 684
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 763 NVYIKNANDNFESYNFSEVAFASYNFWLYDLCDIYLELIKPRLnTDSHDNFVSGlkeksdmnniEKREVVEQNDNNIesv 842
Cdd:PLN02943 685 HELIDSVTTSYDKYFFGDVGREIYDFFWSDFADWYIEASKTRL-YHSGDNSALS----------RAQAVLLYVFENI--- 750
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 843 ntnhineinkcdnyldgyganktlhvcldygLRLLHPISPFITEELYQKIssePYKFNSISLANYPEYINIWHNENINsE 922
Cdd:PLN02943 751 -------------------------------LKLLHPFMPFVTEELWQAL---PYRKEALIVSPWPQTSLPKDLKSIK-R 795
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 923 MNKFMNIVKQFRSFISTLEIPPKTKLNCFIAAKHEedkiFIEKVRTKIEVLAKLSSLSVINYNVE-----DLSDDLKLQV 997
Cdd:PLN02943 796 FENLQSLTRAIRNARAEYSVEPAKRISASIVASAE----VIEYISKEKEVLALLSRLDLQNVHFTdsppgDANQSVHLVA 871
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 998 KKCLKDIVSNQFIIYVQSSEEYLKPLLSsmlnknkKLQASLDSYLKKINDPNYEQKVPEQVRTMYSEKVEELNSQILSIS 1077
Cdd:PLN02943 872 SEGLEAYLPLADMVDISAEVERLSKRLS-------KMQTEYDALAARLSSPKFVEKAPEDVVRGVREKAAEAEEKIKLTK 944
|
.
gi 124810112 1078 N 1078
Cdd:PLN02943 945 N 945
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
53-706 |
0e+00 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 634.06 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 53 KWYSFWEENDYFKPKKElieenkNNEHIKKFVIILPPPNVTGTLHIGHTLTVAIQDSLVRYKRMKNYLTLYIPGTDHAGI 132
Cdd:pfam00133 1 QIYEFWDEQGYFKPELE------KRKGKPSFTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 133 ATQTVVEKMLYKKENKIRQDYGREEFVKKIYEWKDLHGNKINNQMKRIGASVDWSREYFTMNENLSNAVKEAFIKFYESG 212
Cdd:pfam00133 75 PTEQVVEKKLGIKEKKTRHKYGREEFREKCREWKMEYADEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKG 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 213 LIYRDNRLVAWCPHLKTALSDIEVNLEEIKkptkikipsfdhlvevGVLYKFFYQIKDSEE-KIEIATTRIETMLGDVAV 291
Cdd:pfam00133 155 LIYRGKKLVNWSPALNTALSNLEVEYKDVK----------------GPSIHVAFPLADDEGaSLVIWTTTPWTLPGNTAV 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 292 AVHP-------------------------------KDKRYAHLIGKEIVHPFIpNRKIIIIADDFVDMQYGTGAVKITPA 340
Cdd:pfam00133 219 AVNPefdyvitgegyilaeallkslykkgtdkkilEDFRGKELEGKEAIHPFV-NREIPIITDDYVDMEFGTGAVHIAPA 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 341 HDKNDYDMMKRHNLNYINIFTLDGHINENGGKlFQGQHRFECRFKIQEELKKLNLLSDKVPNPMSLPLCSRTNDIIEYML 420
Cdd:pfam00133 298 HGENDYEVGQRHNLEVINPVDDDGTFTEEAPD-FQGVYRFDARKKIVELLTEKGLLLKIEPFTHSYPFCWRSGTPIIPRA 376
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 421 IPQWYMNCSELAHQAIQNVklKELEIIPPQHVNTWYYWLENVRDWCISRQLWWGHRIPAYKIVFKNDVnhntddinhndd 500
Cdd:pfam00133 377 TPQWFVRMDELADQALEAV--EKVQFVPKSGEKRYFNWLANIQDWCISRQRWWGHPIPAWVSKDTEEV------------ 442
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 501 nnddnnnnnnnnnNLEEQNELWVVGRSYEEGLEK-----AKSLVGDNKPfELIQDEDVLDTWFSSSLVPFSSLGWPNQ-T 574
Cdd:pfam00133 443 -------------VCRGELFELVAGRFEEEGSIKwlhreAKDKLGYGKG-TLEQDEDVLDTWFSSGSWPFSTLGWPFVnT 508
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 575 EDLETFFPNTILETGQDILFFWVARMVMVSLHLMKKLPFKTIYLHAMIRDSRGEKMSKSKGNVVDPLDIIDgislnklhe 654
Cdd:pfam00133 509 EEFKKFFPADMLLEGSDQTRGWFYRMIMLSTALTGSVPFKNVLVHGLVRDEQGRKMSKSLGNVIDPLDVID--------- 579
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|..
gi 124810112 655 klyegnlpekeikraielqkkefpkgipECGTDALRFGLLtYLKQGRNVNLD 706
Cdd:pfam00133 580 ----------------------------KYGADALRLWLA-NSDYGRDINLS 602
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
81-705 |
0e+00 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 538.76 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 81 KKFVIILPPPNVTGTLHIGHTLTVAIQDSLVRYKRMKNYLTLYIPGTDHAGIATQTVVEKMLyKKENKIRQDYGREEFVK 160
Cdd:cd00817 1 PVFVIDTPPPNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQVVVEKKL-GIEGKTRHDLGREEFLE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 161 KIYEWKDLHGNKINNQMKRIGASVDWSREYFTMNENLSNAVKEAFIKFYESGLIYRDNRLVAWCPHLKTALSDIEVnlee 240
Cdd:cd00817 80 KCWEWKEESGGKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAISDIEV---- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 241 ikkptkikipsfdhlvevgvlykffyqikdseekieiattrietmlgdvavavhpkdkryahligkeivhpfipnrkiii 320
Cdd:cd00817 --------------------------------------------------------------------------------
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 321 iaddfvdmqygtgavkitpahdkndydmmkrhnlnyiniftldghinenggklfqgqhrfecrfkiqeelkklnllsdkv 400
Cdd:cd00817 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 401 pnpmslplCSRTNDIIEYMLIPQWYMNCSELAHQAIQNVKLKELEIIPPQHVNTWYYWLENVRDWCISRQLWWGHRIPAY 480
Cdd:cd00817 156 --------CSRSGDVIEPLLKPQWFVKVKDLAKKALEAVKEGDIKFVPERMEKRYENWLENIRDWCISRQLWWGHRIPAW 227
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 481 KIVFKNDvnhntddinhnddnnddnnnnnnnnnnleeqnelWVVGRSYEEGLEKAKSLVGD-NKPFELIQDEDVLDTWFS 559
Cdd:cd00817 228 YCKDGGH----------------------------------WVVAREEDEAIDKAAPEACVpCGGEELKQDEDVLDTWFS 273
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 560 SSLVPFSSLGWPNQTEDLETFFPNTILETGQDILFFWVARMVMVSLHLMKKLPFKTIYLHAMIRDSRGEKMSKSKGNVVD 639
Cdd:cd00817 274 SSLWPFSTLGWPEETKDLKKFYPTSLLVTGHDIIFFWVARMIMRGLKLTGKLPFKEVYLHGLVRDEDGRKMSKSLGNVID 353
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 124810112 640 PLDIIDGIslnklheklyegnlpekeikraielqkkefpkgipecGTDALRFGLLTYLKQGRNVNL 705
Cdd:cd00817 354 PLDVIDGY-------------------------------------GADALRFTLASAATQGRDINL 382
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
39-949 |
7.02e-150 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 467.36 E-value: 7.02e-150
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 39 KTMKDAYDPKEVESKWYSFWEENDYFKpkkelieeNKNNEHIKKFVIILPPPNVTGTLHIGHTLTVAIQDSLVRYKRMKN 118
Cdd:PRK13208 4 PELPKKYDPEELEEKWQKIWEEEGTYK--------FDPDERKPVYSIDTPPPTVSGSLHIGHVFSYTHTDFIARYQRMRG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 119 YLTLYIPGTDHAGIATQTVVEkmlykKENKIR-QDYGREEFVKKIYEWKDLHGNKINNQMKRIGASVDWSREYFTMNENL 197
Cdd:PRK13208 76 YNVFFPQGWDDNGLPTERKVE-----KYYGIRkDDISREEFIELCRELTDEDEKKFRELWRRLGLSVDWSLEYQTISPEY 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 198 SNAVKEAFIKFYESGLIYRDNRLVAWCPHLKTALSDIEVnlEEIKKPTKikipsfdhlvevgvLYKFFYQIKDsEEKIEI 277
Cdd:PRK13208 151 RRISQKSFLDLYKKGLIYRAEAPVLWCPRCETAIAQAEV--EYREREGK--------------LNYIKFPVED-GEEIEI 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 278 ATTRIETMLGDVAVAVHPKDKRYAHLIGKEIVHPfIPNRKIIIIADDFVDMQYGTGAVKITPAHDKNDYDMMKRHNLNYI 357
Cdd:PRK13208 214 ATTRPELLPACVAVVVHPDDERYKHLVGKTAIVP-LFGVEVPILADPLVDPDFGTGAVMICTFGDKTDVTWWRELNLPTR 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 358 NIFTLDGHINENGGKLfQGQHRFECRFKIQEELKKLNLLSDKVPNPMSLPLCSRTNDIIEYMLIPQWYMNCSELAHQAIQ 437
Cdd:PRK13208 293 IIIDEDGRMTEAAGKL-AGLTIEEARKKIVEDLKSGGLLGKQEPIKHNVKFCERCDTPLEILVTRQWFIKVLDLKEELLE 371
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 438 NVklKELEIIPPQHVNTWYYWLENVR-DWCISRQ--------LWW----GHRIPAykivfkndvnhntddinhnddnndd 504
Cdd:PRK13208 372 RG--KEINWYPEHMRVRLENWIEGLNwDWCISRQryfgtpipVWYckdcGHPILP------------------------- 424
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 505 nnnnnnnnnnleEQNELWVVGRSyEEGLEKAKSLVGDNkpfELIQDEDVLDTWFSSSLVPFSSLGWPNQTEDLETFFPNT 584
Cdd:PRK13208 425 ------------DEEDLPVDPTK-DEPPGYKCPQCGSP---GFEGETDVMDTWATSSITPLIVTGWERDEDLFEKVFPMD 488
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 585 ILETGQDILFFW----VARmvmvSLHLMKKLPFKTIYLHAMIRDSRGEKMSKSKGNVVDPLDIIDgislnklheklyegn 660
Cdd:PRK13208 489 LRPQGHDIIRTWlfytILR----AYLLTGKLPWKNIMISGMVLDPDGKKMSKSKGNVVTPEELLE--------------- 549
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 661 lpekeikraielqkkefpkgipECGTDALRFGLLTyLKQGRNVNLDINRI-IGYRhFCNKLWNAVKFFLkTLPDNYDnyn 739
Cdd:PRK13208 550 ----------------------KYGADAVRYWAAS-ARLGSDTPFDEKQVkIGRR-LLTKLWNASRFVL-HFSADPE--- 601
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 740 ilIDKPEYVEKLqweDKWILHKLNVYIKNANDNFESYNFSEVAFASYNFWLYDLCDIYLELIKPRLntdshdnfvsglke 819
Cdd:PRK13208 602 --PDKAEVLEPL---DRWILAKLAKVVEKATEALENYDFAKALEEIESFFWHVFCDDYLELVKSRA-------------- 662
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 820 ksdmnniekrevveQNDNNIESVntnhineinkcdnyldgYGANKTLHVCLDYGLRLLHPISPFITEELYQKISSEpykf 899
Cdd:PRK13208 663 --------------YGEDEEEEQ-----------------KSARYTLYTVLDTLLRLLAPFLPFITEEVWSWLYGG---- 707
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|
gi 124810112 900 nSISLANYPEYINIWHNENINSEMNKFMNIVKQFRSFISTLEIPPKTKLN 949
Cdd:PRK13208 708 -SVHRASWPEPDEELIDEEDEELGELAKEILSAVRKYKSEAGLSLNAPLK 756
|
|
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
41-930 |
4.62e-92 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 315.48 E-value: 4.62e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 41 MKdaYDPKEVESKWYSFWEENDYFKpkkELIEENKNNEhikKFVIILPPPNVTGTLHIGHTLTVAIQDSLVRYKRMKNYL 120
Cdd:COG0060 14 MR--ANLPKREPEILKFWEENDIYE---KSREARAGRP---KFVLHDGPPYANGDIHIGHALNKILKDIIVRYKTMRGFD 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 121 TLYIPGTD-HaG--IATQtvVEKMLyKKENKIRQDYGREEFVKK--------IYEWKDlhgnkinnQMKRIGASVDWSRE 189
Cdd:COG0060 86 VPYVPGWDcH-GlpIELK--VEKEL-GIKKKDIEKVGIAEFREKcreyalkyVDEQRE--------DFKRLGVWGDWDNP 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 190 YFTM-NENLSNAVkEAFIKFYESGLIYRDNRLVAWCPHLKTALSDIEVNLEEIKKPTkikipsfdhlvevgVLYKFfyQI 268
Cdd:COG0060 154 YLTMdPEYEESIW-WALKKLYEKGLLYKGLKPVPWCPRCGTALAEAEVEYKDVTSPS--------------IYVKF--PV 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 269 KDSEEKIE-------IATTRIETMLGDVAVAVHP----------KDKRY---------------------------AHLI 304
Cdd:COG0060 217 KDEKALLLledaylvIWTTTPWTLPANLAVAVHPdidyvlvevtGGERLilaealveavlkelgiedyevlatfkgAELE 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 305 GKEIVHPFI----PNRKIIIIADDFVDMQYGTGAVKITPAHDKNDYDMMKRHNLNYINIFTLDGHINENGGKlFQGQHRF 380
Cdd:COG0060 297 GLRYEHPFYyvvgYDRAHPVILGDYVTTEDGTGIVHTAPGHGEDDFEVGKKYGLPVLNPVDDDGRFTEEAPL-FAGLFVK 375
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 381 ECRFKIQEELKKLNLL--SDKVPNpmSLPLCSRT-NDIIeYMLIPQWYMNCSELAHQAIQNVKlkeleiippqHVNtWYY 457
Cdd:COG0060 376 DANPAIIEDLKERGALlaREKITH--SYPHCWRCkTPLI-YRATPQWFISMDKLRDRALEAIE----------KVN-WIP 441
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 458 ---------WLENVRDWCISRQLWWGHRIPaykiVFKNdvnhntddinhnddnnddnnnnnnnnnnlEEQNELW----VV 524
Cdd:COG0060 442 ewgegrfgnMLENRPDWCISRQRYWGVPIP----IWVC-----------------------------EDCGELHrteeVI 488
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 525 GrSYEEGLEK-----------AKSLVGD-------NKPFEliQDEDVLDTWFSSSLVPFSSLgwpNQTEDLEtfFP-NTI 585
Cdd:COG0060 489 G-SVAELLEEegadawfeldlHRPFLDEtlkcpkcGGTMR--RVPDVLDVWFDSGSMHFAVL---ENREELH--FPaDFY 560
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 586 LEtGQDIL---FFwvarmvmvSLHLM-----KKLPFKTIYLHAMIRDSRGEKMSKSKGNVVDPLDIIDgislnKLhekly 657
Cdd:COG0060 561 LE-GSDQTrgwFY--------SSLLTstalfGRAPYKNVLTHGFVLDEDGRKMSKSLGNVVDPQEVID-----KY----- 621
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 658 egnlpekeikraielqkkefpkgipecGTDALRFGLLT--YlkqGRNVNLDINRIIGYRHFCNKLWNAVKFFLKtlpdNY 735
Cdd:COG0060 622 ---------------------------GADILRLWVASsdY---WGDLRFSDEILKEVRDVYRRLRNTYRFLLA----NL 667
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 736 DNYNILIDKPEYvEKLQWEDKWILHKLNVYIKNANDNFESYNFSEVAFASYNFWLYDLCDIYLELIKPRLNTDshdnfvs 815
Cdd:COG0060 668 DDFDPAEDAVPY-EDLPELDRWILSRLNELIKEVTEAYDNYDFHRAYRALHNFCVEDLSNWYLDISKDRLYTE------- 739
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 816 glkeksDMNNIEKRevveqndnniesvntnhineinkcdnyldgyGANKTLHVCLDYGLRLLHPISPFITEELYQKISSE 895
Cdd:COG0060 740 ------AADSLDRR-------------------------------AAQTTLYEVLETLVRLLAPILPFTAEEIWQNLPGE 782
|
970 980 990
....*....|....*....|....*....|....*
gi 124810112 896 PYKfnSISLANYPEYINIWHNENINSEMNKFMNIV 930
Cdd:COG0060 783 AEE--SVHLADWPEVDEELIDEELEAKWDLVREVR 815
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
82-644 |
1.27e-50 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 181.46 E-value: 1.27e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 82 KFVIILPPPNVTGTLHIGHTLTVAIQDSLVRYKRMKNYLTLYIPGTDHAGIATQTVVEKMLYKKENKIRqdygREEFVKK 161
Cdd:cd00668 1 KFYVTTPPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAERKGGRKKKTIW----IEEFRED 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 162 IYEWKDLHGNKINNQMKRIGASVDWSREYFTMNENLSNAVKEAFIKFYESGLIYRDNRLVawcphlktalsdievnleei 241
Cdd:cd00668 77 PKEFVEEMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIFSRLYEKGLIYRGTHPV-------------------- 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 242 kkptkIKIPSFdhlvevgvlykffyqikdseekieiattrietmlgdvavavhpkdkryahligkeivhpfipnrkiiii 321
Cdd:cd00668 137 -----RITEQW--------------------------------------------------------------------- 142
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 322 addFVDMQygtgavkitpahdkndydmmkrhnlnyiniftldghinenggklfqgqhrfecrfKIQEELKKlnllsdkvp 401
Cdd:cd00668 143 ---FFDMP-------------------------------------------------------KFKEKLLK--------- 155
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 402 npmslplcsrtndiieymlipqwymncselahqAIQNVKlkeleIIPPQHVNTWYYWLENVRDWCISRQLWWGHRIPayk 481
Cdd:cd00668 156 ---------------------------------ALRRGK-----IVPEHVKNRMEAWLESLLDWAISRQRYWGTPLP--- 194
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 482 ivfkndvnhntddinhnddnnddnnnnnnnnnnleeqnelwvvgrsyeeglekakslvgdnkpfeliqdEDVLDTWFSSS 561
Cdd:cd00668 195 ---------------------------------------------------------------------EDVFDVWFDSG 205
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 562 LVPFSSLGWPNQTEDLETFFPNTILETGQDILFFWVARMVMVSLHLMKKLPFKTIYLHAMIRDSRGEKMSKSKGNVVDPL 641
Cdd:cd00668 206 IGPLGSLGYPEEKEWFKDSYPADWHLIGKDILRGWANFWITMLVALFGEIPPKNLLVHGFVLDEGGQKMSKSKGNVIDPS 285
|
...
gi 124810112 642 DII 644
Cdd:cd00668 286 DVV 288
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
705-892 |
1.82e-44 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 156.95 E-value: 1.82e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 705 LDINRIIGYRHFCNKLWNAVKFFLktlpDNYDNYNILIDKPEyveKLQWEDKWILHKLNVYIKNANDNFESYNFSEVAFA 784
Cdd:cd07962 1 FDEKRVEGGRNFCNKLWNAARFVL----MNLEDDDEPEEDPE---SLSLADRWILSRLNKTVEEVTEALENYRFSEAATA 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 785 SYNFWLYDLCDIYLELIKPRLNTDShdnfvsglkeksdmnNIEKREVVEqndnniesvntnhineinkcdnyldgygank 864
Cdd:cd07962 74 LYEFFWNDFCDWYLELVKPRLYGED---------------EEEKKAARA------------------------------- 107
|
170 180
....*....|....*....|....*...
gi 124810112 865 TLHVCLDYGLRLLHPISPFITEELYQKI 892
Cdd:cd07962 108 TLYYVLETILRLLHPFMPFITEELWQRL 135
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
51-813 |
1.78e-37 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 152.62 E-value: 1.78e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 51 ESKWYSFWEENDYFKPkkelIEENKNNEHikkFVIILPPPNVTGTLHIGHTLTVAIQDSLVRYKRMKNYLTLYIPGTDHA 130
Cdd:PLN02843 9 EPEIQKLWEENQVYKR----VSDRNNGES---FTLHDGPPYANGDLHIGHALNKILKDFINRYQLLQGKKVHYVPGWDCH 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 131 GIATQTVVEKMLYKKENK----IRQDYGREEFVKKiyewkdlhgnKINNQM---KRIGASVDWSREYFTMNENLSNAVKE 203
Cdd:PLN02843 82 GLPIELKVLQSLDQEARKeltpIKLRAKAAKFAKK----------TVDTQResfKRYGVWGDWENPYLTLDPEYEAAQIE 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 204 AFIKFYESGLIYRDNRLVAWCPHLKTALSDIEVNLEEIKKPTKIKIpSFDhLVEVGVlyKFFYQIKDSEEKIEIA--TTR 281
Cdd:PLN02843 152 VFGQMFLNGYIYRGRKPVHWSPSSRTALAEAELEYPEGHVSKSIYV-AFP-VVSPSE--TSPEELEEFLPGLSLAiwTTT 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 282 IETMLGDVAVAVHPK-------------------------------DKRYAHLI------------------------GK 306
Cdd:PLN02843 228 PWTMPANAAVAVNDKlqysvvevqsfsedestsggnkkkrpgnvlkEQQKLFLIvatdlvpaleakwgvklvvlktfpGS 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 307 EIV-----HPFIPNRKIIIIADDFVDMQYGTGAVKITPAHDKNDYDMMKRHNLNYINIFTLDGHINENGGKlFQGqhrfe 381
Cdd:PLN02843 308 DLEgcryiHPLYNRESPVVIGGDYITTESGTGLVHTAPGHGQEDYITGLKYGLPLLSPVDDAGKFTEEAGQ-FSG----- 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 382 crfkiqeelkkLNLLSD-------KVPNPMSL----------PLCSRTNDIIEYMLIPQWYMNCS---ELAHQAIQNVKL 441
Cdd:PLN02843 382 -----------LSVLGEgnaavveALDEAGSLlmeeayghkyPYDWRTKKPTIFRATEQWFASVEgfrQAALDAIDKVKW 450
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 442 keleiIPPQHVNTWYYWLENVRDWCISRQLWWGHRIPAYKIVFKND-------VNHNTDDINhnddnnddnnnnnnnnnn 514
Cdd:PLN02843 451 -----IPAQGENRIRAMVSGRSDWCISRQRTWGVPIPVFYHVETKEplmneetIAHVKSIVA------------------ 507
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 515 lEEQNELWVVgRSYEEGL-EKAKslvgdNKPFELIQDEDVLDTWFSSSlvpfSSLGWPNQTEDlETFFPNTILETGQDIL 593
Cdd:PLN02843 508 -QKGSDAWWY-MDVEDLLpEKYR-----DKASDYEKGTDTMDVWFDSG----SSWAGVLGSRE-GLSYPADLYLEGSDQH 575
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 594 FFWVARMVMVSLHLMKKLPFKTIYLHAMIRDSRGEKMSKSKGNVVDPLDIIDGislnklheklyeGNlpekeikraieLQ 673
Cdd:PLN02843 576 RGWFQSSLLTSVATKGKAPYKSVLTHGFVLDEKGFKMSKSLGNVVDPRLVIEG------------GK-----------NQ 632
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 674 KKEfpkgiPECGTDALRFGLltylkqgRNVNLDINRIIG----------YRhfcnKLWNAVKFFLKTL----PDNYDNYN 739
Cdd:PLN02843 633 KQE-----PAYGADVLRLWV-------ASVDYTGDVLIGpqilkqmsdiYR----KLRGTLRYLLGNLhdwkPDNAVPYE 696
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 124810112 740 iliDKPEYveklqweDKWILHKLNVYIKNANDNFESYNFSEVAFASYNFWLYDLCDIYLELIKPRLNTDSHDNF 813
Cdd:PLN02843 697 ---DLPSI-------DKYALFQLENVVNEIEESYDNYQFFKIFQILQRFTIVDLSNFYLDVAKDRLYVGGTTSF 760
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
49-892 |
1.66e-31 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 133.94 E-value: 1.66e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 49 EVESKWYSFWEENDYFKPKKELiEENKnnehiKKFVIILPPPNVTGTLHIGHTLTVAIQDSLVRYKRMKNYLTLYIPGTD 128
Cdd:PTZ00427 76 EEEEKVLKYWKSIDAFNTSNKL-AKNK-----KAYIFYDGPPFATGLPHYGHLLAGIIKDCVTRYFYQCGFSVERKFGWD 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 129 HAGIATQTVVEKmlykkENKIRQdygREEFVK---KIYEWKDL-----HGNKINNQMKRIGASVDWSREYFTMNENLSNA 200
Cdd:PTZ00427 150 CHGLPIEYEIEK-----ENNINK---KEDILKmgiDVYNEKCRgivlkYSNEWVKTVERIGRWIDFKNDYKTMDKTFMES 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 201 VKEAFIKFYESGLIYRDNRLVAWCPHLKTALSDIEVNL-----------------------------EEIKKP------- 244
Cdd:PTZ00427 222 VWWVFSELYKNNYVYKSFKVMPYSCKCNTPISNFELNLnykdtpdpsiiisfvlcsdfpkveeecniEEDKQLlgekysv 301
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 245 ---------------------------------TKIKIPSFDHL-VEVGVLYKFFYQIKdSEEKIEIATTRIETMLGDVA 290
Cdd:PTZ00427 302 lynnkrensnngnnnstnnvcyaqhseilawttTPWTLPSNLALcVNEHFTYLRIHHVK-SNRVVIVGECRLEWIMKELK 380
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 291 VAV------------HPKDKRYAHLIGKEIVHPFIPNRKIIIIADDFVDMQYGTGAVKITPAHDKNDYDMMKRHNLN--- 355
Cdd:PTZ00427 381 WNVedlkivnrfkgkELKGLRYKPLFTNFYEKYNFKERAYKILADDFVTDDAGTGIVHCAPTYGEDDFRVCKKNGVIdpe 460
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 356 ---YINIFTLDGHINeNGGKLFQGQHRFECRFKIQEELKKLNLLSDKVPNPMSLPLCSRTNDIIEYMLIPQWYMNCSELA 432
Cdd:PTZ00427 461 kniFIDPLDANGYFT-NEVEEVQNLYIKEADNVIKKKLKNENRLLSNNTIVHSYPFCWRSDTPLIYRAIPAWFIRVSNST 539
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 433 HQAIQNvklKELEIIPPQHVN--TWYYWLENVRDWCISRQLWWGHRIPAY------KIVFKNDVNHntddinhnddnndd 504
Cdd:PTZ00427 540 NELVKN---NETTYWIPAHIKekKFHNWIKDAKDWCISRNRYWGTPIPIWadekmeTVICVESIKH-------------- 602
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 505 nnnnnnnnnnLEEQNELWVVG---RSYEEGLEkAKSLVGDNKPfELIQDEDVLDTWFSSSLVPFSSLGWP--NQTEDLET 579
Cdd:PTZ00427 603 ----------LEELSGVKNINdlhRHFIDHIE-IKNPKGKTYP-KLKRIPEVFDCWFESGSMPYAKVHYPfsTEKEDFHK 670
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 580 FFPNTILETGQDILFFWVARMVMVSLHLMKKLPFKTIYLHAMIRDSRGEKMSKSKGNVVDPLDIIDGISLNKLheKLYeg 659
Cdd:PTZ00427 671 IFPADFIAEGLDQTRGWFYTLLVISTLLFDKAPFKNLICNGLVLASDGKKMSKRLKNYPDPLYILDKYGADSL--RLY-- 746
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 660 nLPEKEIKRAIELQKKEfpKGIPEcgtdALRFGLLTYLKQGRNVNLDINRIigyrhfcnKLWNAVKFFLKTLPdNYDNYN 739
Cdd:PTZ00427 747 -LINSVAVRAENLKFQE--KGVNE----VVKSFILPFYHSFRFFSQEVTRY--------ECLNKKQFLFNTDY-IYKNDN 810
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 740 ILidkpeyveklqweDKWILHKLNVYIKNANDNFESYNFSEVAFASYNFwLYDLCDIYLelikpRLNTDShdnfvsglke 819
Cdd:PTZ00427 811 IM-------------DQWIFSSVQSLTKSVHTEMKAYKLYNVLPKLLQF-IENLTNWYI-----RLNRDR---------- 861
|
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 124810112 820 ksdMNNIEKREvveqndNNIESVNTNHineinkcdnyldgyganKTLHVCldygLRLLHPISPFITEELYQKI 892
Cdd:PTZ00427 862 ---MRGSLGEE------NCLQSLCTTY-----------------RTLHLF----TVLMAPFTPFITEYIYQQL 904
|
|
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
41-645 |
2.69e-31 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 132.48 E-value: 2.69e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 41 MKDAYDPKEVESKWYSFWEENDYFKPkkeliEENKNNEhiKKFVII-LPPPnvTGTLHIGHTLTVAIQDSLVRYKRMKNY 119
Cdd:COG0495 1 MQERYNPKEIEKKWQKYWEENGTFKA-----DEDSSKP--KYYVLDmFPYP--SGRLHMGHVRNYTIGDVVARYKRMQGY 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 120 LTLYiP-GTD-------HAGIATQTVVEKMLYkkENkirqdygreefvkkiyewkdlhgnkINN---QMKRIGASVDWSR 188
Cdd:COG0495 72 NVLH-PmGWDafglpaeNAAIKNGVHPAEWTY--EN-------------------------IANmrrQLKRLGLSYDWSR 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 189 E-------YFTMNENLsnavkeaFIKFYESGLIYRDNRLVAWCPHLKTALSDIEV--------NLEEIKKPTK---IKIP 250
Cdd:COG0495 124 EiatcdpeYYKWTQWI-------FLQLYEKGLAYRKEAPVNWCPVDQTVLANEQVidgrcwrcGAPVEKKELPqwfLKIT 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 251 SF-DHLVE-----------------------VGVLYKFfyQIKDSEEKIEIATTRIETMLGD--VAVAV-HP-------- 295
Cdd:COG0495 197 DYaDELLDdldkldgwpekvktmqrnwigrsEGAEVDF--PVEGSDEKITVFTTRPDTLFGAtfMVLAPeHPlvkelatp 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 296 -------------------------KDK------RYAhligkeiVHPF----IPnrkiIIIAdDFVDMQYGTGAVKITPA 340
Cdd:COG0495 275 eqnaavaafieeakkkseiertsetKEKtgvftgLYA-------INPLtgekIP----IWIA-DYVLMDYGTGAVMAVPA 342
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 341 HDKNDYDMMKRHNLNYIN-IFTLDGHINENG-------GKL-----FQGQHRFECRFKIQEELKKLNLLSDKVpnpmslp 407
Cdd:COG0495 343 HDQRDFEFAKKYGLPIKQvIAPEDGDDPDILeeaytgdGVLinsgeFDGLDSEEAKEAIIEWLEEKGLGKRKV------- 415
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 408 lcsrtndiieymlipqwymncselahqaiqNVKLkeleiippqhvntwyywlenvRDWCISRQLWWGHRIPaykIVFKND 487
Cdd:COG0495 416 ------------------------------NYRL---------------------RDWLISRQRYWGEPIP---IIHCED 441
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 488 -----VnhntddinhnddnnddnnnnnnnnnnLEEQneLWVV-------GRSYEEGLEKAKSLV-----GDNKPFEliQD 550
Cdd:COG0495 442 cgvvpV--------------------------PEDQ--LPVElpedvdfDPTGGSPLARAPEWVnvtcpKCGGPAR--RE 491
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 551 EDVLDTWFSSSlvpfsslgW-------PNQTEDLetffpntileTGQDILFFW-------------VarmvmvsLHL--- 607
Cdd:COG0495 492 TDTMDTFVDSS--------WyylrytdPHNDEAP----------FDPEAANYWlpvdqyiggiehaI-------LHLlya 546
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|....*....
gi 124810112 608 ------MKKL-------PFKTIYLHAMIRD--------SRGEKMSKSKGNVVDPLDIID 645
Cdd:COG0495 547 rfftkvLRDLglvsfdePFKRLLTQGMVLEvgkdgvviGGIEKMSKSKGNVVDPDEIIE 605
|
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
42-982 |
1.35e-30 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 131.00 E-value: 1.35e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 42 KDAYDPKEvESKWYSFWEENDYFKpkkeliEENKNNEHIKKFVIILPPPNVTGTLHIGHTLTVAIQDSLVRYKRMKNYLT 121
Cdd:PLN02882 6 KDFSFPKQ-EEKILSLWSEIDAFK------TQLKRTEGLPEYIFYDGPPFATGLPHYGHILAGTIKDIVTRYQSMTGHHV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 122 LYIPGTDHAGIAtqtvVEKMLYKKEN-KIRQD--------YGRE------EFVKkiyEWKDLhgnkinnqMKRIGASVDW 186
Cdd:PLN02882 79 TRRFGWDCHGLP----VEYEIDKKLGiKRRDDvlkmgidkYNEEcrsivtRYSK---EWEKT--------VTRTGRWIDF 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 187 SREYFTMNENLSNAVKEAFIKFYESGLIYRDNRLVAWCPHLKTALSDIEVNLE--EIKKPtkikipsfdhlvEVGVLykf 264
Cdd:PLN02882 144 ENDYKTMDPKFMESVWWVFKQLFEKGLVYKGFKVMPYSTACKTPLSNFEAGLNykDVSDP------------AVMVS--- 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 265 FYQIKDSEEKIEIA-TTRIETMLGDVAVAVHP-----------KDKRY-------------------------------- 300
Cdd:PLN02882 209 FPIVGDPDNASFVAwTTTPWTLPSNLALCVNPnftyvkvrnkyTGKVYivaesrlsalptakpkskkgskpenaaegyev 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 301 -AHLIGKEIV----HPFIP------NRKIIIIADDFVDMQYGTGAVKITPAHDKNDYDMMKRHNL-----NYINIFTLDG 364
Cdd:PLN02882 289 lAKVPGSSLVgkkyEPLFDyfsefsDTAFRVVADDYVTDDSGTGVVHCAPAFGEDDYRVCLANGIiekggNLPVPVDDDG 368
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 365 HINENGGKlFQGQHRFECRFKIQEELKKLNLLSDKVPNPMSLPLCSRTNDIIEYMLIPQWYMNCSELAHQAIQNVKLKEL 444
Cdd:PLN02882 369 CFTEKVTD-FSGRYVKDADKDIIAAIKAKGRLVKSGSITHSYPFCWRSDTPLIYRAVPSWFVKVEEIKDRLLENNKQTYW 447
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 445 eiiPPQHVNT--WYYWLENVRDWCISRQLWWGHRIPAYkivfkndvnhntddinhnddnnddnnnnnnnnnnLEEQNELW 522
Cdd:PLN02882 448 ---VPDYVKEkrFHNWLENARDWAVSRSRFWGTPLPIW----------------------------------ISDDGEEV 490
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 523 VVGRSYEEgLEKAKSLVGDNKPFELIQD-----------------EDVLDTWFSSSLVPFSSLGWPNQTEDL-ETFFPNT 584
Cdd:PLN02882 491 VVIGSIAE-LEKLSGVKVTDLHRHFIDHitipssrgpefgvlrrvDDVFDCWFESGSMPYAYIHYPFENKELfEKNFPAD 569
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 585 ILETGQDILFFWVARMVMVSLHLMKKLPFKTIYLHAMIRDSRGEKMSKSKGNVVDPLDIIDGISLNKLheKLYEGNLPek 664
Cdd:PLN02882 570 FVAEGLDQTRGWFYTLMVLSTALFDKPAFKNLICNGLVLAEDGKKMSKSLKNYPDPNEVIDKYGADAL--RLYLINSP-- 645
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 665 eIKRAIELQKKEfpKGIpecgtdalrFGLLtylkqgRNVNLdinriigyrhfcnKLWNAVKFFLKTLP----DNYDNYNi 740
Cdd:PLN02882 646 -VVRAEPLRFKE--EGV---------FGVV------KDVFL-------------PWYNAYRFLVQNAKrlevEGGAPFV- 693
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 741 lidkPEYVEKLQWE----DKWILHKLNVYIKNANDNFESYNFSEVAFASYNFwLYDLCDIYLELIKPRLNtdshdnfvsG 816
Cdd:PLN02882 694 ----PLDLAKLQNSanvlDRWINSATQSLVKFVREEMGAYRLYTVVPYLVKF-IDNLTNIYVRFNRKRLK---------G 759
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 817 LKEKSDmnniekrevveqndnniesvntnhineinkCDNYLDgygankTLHVCLDYGLRLLHPISPFITEELYQKI-SSE 895
Cdd:PLN02882 760 RTGEED------------------------------CRTALS------TLYNVLLTSCKVMAPFTPFFTEVLYQNLrKVL 803
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 896 PYKFNSISLANYPEYINIWHNENINSEMNKFMNIVKQFRSFISTLEIPPKTKLNCFIAAKHEEDkiFIEKVRTKIE--VL 973
Cdd:PLN02882 804 PGSEESIHYCSFPQVDEGELDERIEQSVSRMQTVIELARNIRERHNKPLKTPLKEMVVVHPDAE--FLDDITGKLKeyVL 881
|
....*....
gi 124810112 974 AKLSSLSVI 982
Cdd:PLN02882 882 EELNVRSLV 890
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
81-645 |
9.41e-30 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 121.57 E-value: 9.41e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 81 KKFVIILPPPNVTGTLHIGHTLTVAIQDSLVRYKRMKNYLTLYIPGTDHAGIATQTVVEKMLYKKENKIRQDYGREEFVK 160
Cdd:cd00818 1 PEFVFHDGPPYANGLPHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGLPIELKVEKELGISGKKDIEKMGIAEFNA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 161 KIYEWKDLHGNKINNQMKRIGASVDWSREYFTMNENLSNAVKEAFIKFYESGLIYRDNRLVAWcphlktalsdievnlee 240
Cdd:cd00818 81 KCREFALRYVDEQEEQFQRLGVWVDWENPYKTMDPEYMESVWWVFKQLHEKGLLYRGYKVVPW----------------- 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 241 ikkptkikipsfdhlvevGVLYKffyqikdseekieiATtrietmlgdvavavhpkdkryahligkeivhpfipnrkiii 320
Cdd:cd00818 144 ------------------PLIYR--------------AT----------------------------------------- 150
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 321 iaddfvdmqygtgavkitpahdkndydmmkrhnlnyiniftldghinenggklfqgqhrfecrfkiqeelkklnllsdkv 400
Cdd:cd00818 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 401 pnpmslplcsrtndiieymliPQWYMNCSELAHQAIQNvkLKELEIIPPQHVNTWYYWLENVRDWCISRQLWWGHRIPay 480
Cdd:cd00818 151 ---------------------PQWFIRVTKIKDRLLEA--NDKVNWIPEWVKNRFGNWLENRRDWCISRQRYWGTPIP-- 205
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 481 kiVFKNDvnhntddinhnddnnddnnnnnnnnnnleeqnelwvvgrsyeeglekakslvgDNKPFELIQDEDVLDTWFSS 560
Cdd:cd00818 206 --VWYCE-----------------------------------------------------DCGEVLVRRVPDVLDVWFDS 230
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 561 SLVPFSSLGWPNQTEDLETFFP-NTILEtGQDILFFWVARMVMVSLHLMKKLPFKTIYLHAMIRDSRGEKMSKSKGNVVD 639
Cdd:cd00818 231 GSMPYAQLHYPFENEDFEELFPaDFILE-GSDQTRGWFYSLLLLSTALFGKAPYKNVIVHGFVLDEDGRKMSKSLGNYVD 309
|
....*.
gi 124810112 640 PLDIID 645
Cdd:cd00818 310 PQEVVD 315
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
96-946 |
2.60e-28 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 123.05 E-value: 2.60e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 96 LHIGHTLTVAIQDSLVRYKRMKNYLTLY-----IPGTDHAGIATQ------TVVEkmLYKKENKIRQDYgREEFVKKIYe 164
Cdd:PRK12300 1 LHVGHGRTYTIGDVIARYKRMRGYNVLFpmafhVTGTPILGIAERiargdpETIE--LYKSLYGIPEEE-LEKFKDPEY- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 165 WKDLHGNKINNQMKRIGASVDWSREYFTMNENLSNAVKEAFIKFYESGLIYRDNRLVAWCPHLKTA------LSDIEVNL 238
Cdd:PRK12300 77 IVEYFSEEAKEDMKRIGYSIDWRREFTTTDPEYSKFIEWQFRKLKEKGLIVKGSHPVRYCPNDNNPvgdhdlLDGEEPEI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 239 EEIkkptkikipsfdhlvevgVLYKFfyqiKDSEEKIEI-ATTRIETMLGDVAVAVHP---------KDKRY-------- 300
Cdd:PRK12300 157 VEY------------------TLIKF----EESEDLILPaATLRPETIFGVTNLWVNPdatyvkaevDGEKWivskeaae 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 301 --AH---------------LIGKEIVHPfIPNRKIIIIADDFVDMQYGTGAVKITPAHDKNDY----DMMKRHNL----N 355
Cdd:PRK12300 215 klSFqdrdveiieeikgseLIGKKVKNP-VTGKEVPILPADFVDPDNGTGVVMSVPAHAPYDYvalrDLKKNKELldviE 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 356 YINIFTLDGH--------------------------------------INENGGKlFQGQHRFECRFKIQEELKKLNlLS 397
Cdd:PRK12300 294 PIPLIEVEGYgefpakevveklgiksqedpeleeatkevyraefhkgvLKENTGE-YAGKPVREAREKITKDLIEKG-IA 371
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 398 DKVPNPMSLPLCSRT-NDIIEYMLIPQWYMNCS-----ELAHQAIQNvklkeLEIIPPQHVNTWYYWLENVRDWCISRQL 471
Cdd:PRK12300 372 DIMYEFSNRPVYCRCgTECVVKVVKDQWFIDYSdpewkELAHKALDN-----MEIIPEEYRKEFENTIDWLKDRACARRR 446
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 472 WWGHRIPaykivFKNDvnhntddinhnddnnddnnnnnnnnnnleeqnelWVVgrsyeEGLEK----------AKSLVGD 541
Cdd:PRK12300 447 GLGTRLP-----WDEE----------------------------------WII-----ESLSDstiymayytiAHKIREY 482
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 542 NKPFELIQDEdVLDTWF----SSSLVpFSSLGWPNQT-----EDLETFFPNTILETGQDilffwvarmvMVSLHLM---- 608
Cdd:PRK12300 483 GIKPEQLTPE-FFDYVFlgkgDPEEV-SKKTGIPKEIleemrEEFLYWYPVDWRHSGKD----------LIPNHLTffif 550
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 609 --------KKLPfKTIYLHAMIRdSRGEKMSKSKGNVvdpldiidgISLNKlheklyegnlpekeikrAIElqkkefpkg 680
Cdd:PRK12300 551 nhvaifpeEKWP-RGIVVNGFVL-LEGKKMSKSKGNV---------IPLRK-----------------AIE--------- 593
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 681 ipECGTDALRFglltYLKQGRNVNLDINriigyrhFCNKLWNAVKfflKTLPDNYDNYNILIDKPEyVEKLQWEDKWILH 760
Cdd:PRK12300 594 --EYGADVVRL----YLTSSAELLQDAD-------WREKEVESVR---RQLERFYELAKELIEIGG-EEELRFIDKWLLS 656
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 761 KLNVYIKNANDNFESYNFSEVAFASYnFWLYDLCDIYLELIkprlntdshdnfvsglkekSDMNNIEKREVveqndnnie 840
Cdd:PRK12300 657 RLNRIIKETTEAMESFQTRDAVQEAF-YELLNDLRWYLRRV-------------------GEANNKVLREV--------- 707
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 841 svntnhineinkcdnyldgyganktlhvcLDYGLRLLHPISPFITEELYQKISSEPYkfnsISLANYPEYINIWHNENIN 920
Cdd:PRK12300 708 -----------------------------LEIWIRLLAPFTPHLAEELWHKLGGEGF----VSLEKWPEPDESKIDEEAE 754
|
970 980
....*....|....*....|....*.
gi 124810112 921 SEMNKFMNIVKQFRSFISTLEIPPKT 946
Cdd:PRK12300 755 LAEEYVKRLIEDIREILKVAKIKPKK 780
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
755-948 |
3.40e-27 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 107.87 E-value: 3.40e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 755 DKWILHKLNVYIKNANDNFESYNFSEVAFASYNFWLYDLCDIYLELIKPRLNTDSHDnfvsglkeksdmnniekrevveq 834
Cdd:pfam08264 1 DRWILSRLNKLIKEVTEAYENYRFNTAAQALYEFFWNDLSDWYLELIKDRLYGEEPD----------------------- 57
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 835 ndnniesvntnhineinkcdnyldgYGANKTLHVCLDYGLRLLHPISPFITEELYQKIssepykfnSISLANYPEYINIW 914
Cdd:pfam08264 58 -------------------------SRAQTTLYEVLETLLRLLAPFMPFITEELWQKE--------SIHLAPWPEDAELE 104
|
170 180 190
....*....|....*....|....*....|....
gi 124810112 915 hNENINSEMNKFMNIVKQFRSFISTLEIPPKTKL 948
Cdd:pfam08264 105 -EAELEEAFELRQEIVQAIRKLRSELKIKKSLPL 137
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
42-480 |
8.11e-27 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 118.39 E-value: 8.11e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 42 KDAYDPKEVESKWYSFWEENDYFKpKKELIEENKNnehiKKFVI-ILPPPNVTGtLHIGHTLTVAIQDSLVRYKRMKNYL 120
Cdd:PLN02563 77 KRAYPFHEIEPKWQRYWEENRTFR-TPDDVDTSKP----KFYVLdMFPYPSGAG-LHVGHPEGYTATDILARYKRMQGYN 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 121 TLYIPGTDHAGI-ATQTVVEKMLYKKENKIRqdygreefvkkiyewkdlHGNKINNQMKRIGASVDWSREYFTMNENLSN 199
Cdd:PLN02563 151 VLHPMGWDAFGLpAEQYAIETGTHPKITTLK------------------NIARFRSQLKSLGFSYDWDREISTTEPEYYK 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 200 AVKEAFIKFYESGLIYRDNRLVAWCPHLKTALSDIEV--NLEE------IKKPTK---IKIPSF-DHLVE---------- 257
Cdd:PLN02563 213 WTQWIFLQLLKRGLAYQAEVPVNWCPALGTVLANEEVvdGLSErgghpvIRKPMRqwmLKITAYaDRLLEdlddldwpes 292
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 258 ------------VGVLYKFF---YQIKDSEEKIEIATTRIETMLGDVAVAV---HPKDKRYAHLIGKEIVHPF------- 312
Cdd:PLN02563 293 ikemqrnwigrsEGAELDFSvldGEGKERDEKITVYTTRPDTLFGATYLVVapeHPLLSSLTTAEQKEAVEEYvdaasrk 372
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 313 ------------------------IPNRKIIIIADDFVDMQYGTGAVKITPAHDKNDYDMMKRHNLNYINI--------- 359
Cdd:PLN02563 373 sdlertelqkektgvftgsyainpATGEAIPIWVADYVLGSYGTGAIMAVPAHDTRDFEFAQKFDLPIKWVvkpadgned 452
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 360 -----FTLDGhINENGGKL---FQGQHRFECRFKIQEELKKLNLLSDKVpnpmslplcsrtndiieymlipqwymncsel 431
Cdd:PLN02563 453 daekaYTGEG-VIVNSSSSgldINGLSSKEAAKKVIEWLEETGNGKKKV------------------------------- 500
|
490 500 510 520
....*....|....*....|....*....|....*....|....*....
gi 124810112 432 ahqaiqNVKLkeleiippqhvntwyywlenvRDWCISRQLWWGHRIPAY 480
Cdd:PLN02563 501 ------NYKL---------------------RDWLFARQRYWGEPIPVV 522
|
|
| Anticodon_Ia_Ile_ABEc |
cd07961 |
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ... |
714-930 |
4.93e-18 |
|
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153415 [Multi-domain] Cd Length: 183 Bit Score: 82.98 E-value: 4.93e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 714 RHFCNKLWNAVKFFlkTLPDNYDNYNILIDKPeYVEKLQWEDKWILHKLNVYIKNANDNFESYNFSEVAFASYNFWLyDL 793
Cdd:cd07961 11 RKVLLPLWNAYRFF--VTYANLDGFDPGKDDD-AVASLNVLDRWILSRLNSLIKEVTEEMEAYDLYTAVRALLEFID-EL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 794 CDIYLELIKPRLntdshdnfvsglkeKSDMNNIEKREVVEqndnniesvntnhineinkcdnyldgygankTLHVCLDYG 873
Cdd:cd07961 87 TNWYIRRNRKRF--------------WGEEGDDDKLAAYA-------------------------------TLYEVLLTL 121
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 124810112 874 LRLLHPISPFITEELYQKIS-SEPYKFNSISLANYPEYINIWHNENINSEMNKFMNIV 930
Cdd:cd07961 122 SRLMAPFTPFITEEIYQNLRrELGDAPESVHLLDWPEVDESLIDEELEEAMELVREIV 179
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
82-228 |
2.59e-16 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 81.14 E-value: 2.59e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 82 KFVIILPPPNVTGTLHIGHTLTVAIQDSLVRYKRMKNYLTLYIPGTDhagiATQTVVEKMlykkENKIRQDYgreefvkk 161
Cdd:cd00812 1 KFYILVMFPYPSGALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFD----AFGLPAENA----AIKIGRDP-------- 64
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 124810112 162 iYEWKDLHGNKINNQMKRIGASVDWSREYFTMNENLSNAVKEAFIKFYESGLIYRDNRLVAWCPHLK 228
Cdd:cd00812 65 -EDWTEYNIKKMKEQLKRMGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKKEAPVNWCKLLD 130
|
|
| Anticodon_Ia_Ile_BEm |
cd07960 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; ... |
713-933 |
3.87e-14 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153414 [Multi-domain] Cd Length: 180 Bit Score: 71.79 E-value: 3.87e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 713 YRhfcnKLWNAVKFFLKTLPDnydnYNILIDKPEYvEKLQWEDKWILHKLNVYIKNANDNFESYNFSEVAFASYNFWLYD 792
Cdd:cd07960 13 YR----KIRNTFRFLLGNLND----FDPAKDAVPY-EELLELDRYALHRLNELIKEVREAYENYEFHKVYQALNNFCTVD 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 793 LCDIYLELIKPRLNTDShdnfvsglkeksdMNNIEKRevveqndnnieSVNTnhineinkcdnyldgygankTLHVCLDY 872
Cdd:cd07960 84 LSAFYLDIIKDRLYCDA-------------KDSLERR-----------SAQT--------------------VLYHILDA 119
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 124810112 873 GLRLLHPISPFITEELYQkISSEPYKFNSISLANYPEYINIWHNENINSEMNKFMNIVKQF 933
Cdd:cd07960 120 LLKLLAPILPFTAEEVWE-HLPGEKKEESVFLEDWPELPEEWKDEELEEKWEKLLALRDEV 179
|
|
| tRNA-synt_1_2 |
pfam13603 |
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ... |
263-354 |
4.38e-11 |
|
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ligase or Leucyl-tRNA synthetase, EC:6.1.1.4.
Pssm-ID: 433342 [Multi-domain] Cd Length: 185 Bit Score: 62.95 E-value: 4.38e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 263 KFFYQIKDSEEKIEIATTRIETMLGD--VAVAV-HP-------KDKRYAHLI-----------------------GKEIV 309
Cdd:pfam13603 11 EITFPVEGTDEKIEVFTTRPDTLMGVtfVALAPeHPlveklaeKNPEVAAFIeeckntseiertsetkekegvftGLYAI 90
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 124810112 310 HPfIPNRKIIIIADDFVDMQYGTGAVKITPAHDKNDYDMMKRHNL 354
Cdd:pfam13603 91 HP-ITGEKIPIWIANFVLMEYGTGAVMAVPAHDQRDFEFAKKYNL 134
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
83-236 |
1.83e-10 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 64.23 E-value: 1.83e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 83 FVIILPPPNVTGTLHIGHTLTVAIQDSLVRYKRMKNYLTLYIPGTDHAGIATQTVVEkmlykKENKirqdyGREEFVKKI 162
Cdd:pfam09334 1 ILVTTALPYANGPPHLGHLYSYIPADIFARYLRLRGYDVLFVCGTDEHGTPIELKAE-----KEGI-----TPEELVDRY 70
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 124810112 163 YEwkdlhgnkinnQMKRIGASVDWSREYF--TMNENLSNAVKEAFIKFYESGLIYRDNRLVAWCPHLKTALSDIEV 236
Cdd:pfam09334 71 HE-----------IHREDFKKFNISFDDYgrTTSERHHELVQEFFLKLYENGYIYEKEIEQFYCPSDERFLPDRYV 135
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
81-218 |
3.73e-10 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 63.75 E-value: 3.73e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 81 KKFVIILPPPNVTGTLHIGHTLTVAIQDSLVRYKRMKNYLTLYIPGTDHAGiatqtvvEKMLYKKENKirqdyGR--EEF 158
Cdd:PRK11893 1 KKFYITTPIYYPNGKPHIGHAYTTLAADVLARFKRLRGYDVFFLTGTDEHG-------QKIQRKAEEA-----GIspQEL 68
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 124810112 159 VKKIYE-WKDLhgnkinnqMKRIGASVD-WSReyfTMNENLSNAVKEAFIKFYESGLIYRDN 218
Cdd:PRK11893 69 ADRNSAaFKRL--------WEALNISYDdFIR---TTDPRHKEAVQEIFQRLLANGDIYLGK 119
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
82-226 |
4.17e-10 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 62.55 E-value: 4.17e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 82 KFVIILPPPNVTGTLHIGHTLTVAIQDSLVRYKRMKNYLTLYIPGTDHAGIATQTVVEkmlykKENKIRQDYGRE--EFV 159
Cdd:cd00814 1 KVLITTALPYVNGVPHLGHLYGTVLADVFARYQRLRGYDVLFVTGTDEHGTKIEQKAE-----EEGVTPQELCDKyhEIF 75
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 124810112 160 KKIYEWkdlhgnkinnqmkrigASVDWSREYFTMNENLSNAVKEAFIKFYESGLIYRDNRLVAWCPH 226
Cdd:cd00814 76 KDLFKW----------------LNISFDYFIRTTSPRHKEIVQEFFKKLYENGYIYEGEYEGLYCVS 126
|
|
| metG |
TIGR00398 |
methionine--tRNA ligase; The methionyl-tRNA synthetase (metG) is a class I amino acyl-tRNA ... |
83-237 |
4.39e-10 |
|
methionine--tRNA ligase; The methionyl-tRNA synthetase (metG) is a class I amino acyl-tRNA ligase. This model appears to recognize the methionyl-tRNA synthetase of every species, including eukaryotic cytosolic and mitochondrial forms. The UPGMA difference tree calculated after search and alignment according to this model shows an unusual deep split between two families of MetG. One family contains forms from the Archaea, yeast cytosol, spirochetes, and E. coli, among others. The other family includes forms from yeast mitochondrion, Synechocystis sp., Bacillus subtilis, the Mycoplasmas, Aquifex aeolicus, and Helicobacter pylori. The E. coli enzyme is homodimeric, although monomeric forms can be prepared that are fully active. Activity of this enzyme in bacteria includes aminoacylation of fMet-tRNA with Met; subsequent formylation of the Met to fMet is catalyzed by a separate enzyme. Note that the protein from Aquifex aeolicus is split into an alpha (large) and beta (small) subunit; this model does not include the C-terminal region corresponding to the beta chain. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273058 [Multi-domain] Cd Length: 530 Bit Score: 63.55 E-value: 4.39e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 83 FVIILPPPNVTGTLHIGHTLTVAIQDSLVRYKRMKNYLTLYIPGTDHAGIATQTVVEKmlykkenkirQDYGREEFVKKI 162
Cdd:TIGR00398 1 ILITTALPYANGKPHLGHAYTTILADVYARYKRLRGYEVLFVCGTDEHGTKIELKAEQ----------EGLTPKELVDKY 70
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 124810112 163 YEwkdlhgnKINNQMKRIGASVDwsreYF--TMNENLSNAVKEAFIKFYESGLIYRDNRLVAWCPHLKTALSDIEVN 237
Cdd:TIGR00398 71 HE-------EFKDDWKWLNISFD----RFirTTDEEHKEIVQKIFQKLKENGYIYEKEIKQLYCPECEMFLPDRYVE 136
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
81-217 |
1.30e-08 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 59.04 E-value: 1.30e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 81 KKFVIILPPPNVTGTLHIGHTLTVAIQDSLVRYKRMKNYLTLYIPGTDHAGiatQTVVEKMlyKKENKIRQdygreEFVK 160
Cdd:PRK12267 4 KTFYITTPIYYPNGKPHIGHAYTTIAADALARYKRLQGYDVFFLTGTDEHG---QKIQQAA--EKAGKTPQ-----EYVD 73
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 124810112 161 KIYEwkdlhgnKINNQMKRIGASVDwsreYF--TMNENLSNAVKEAFIKFYESGLIYRD 217
Cdd:PRK12267 74 EISA-------GFKELWKKLDISYD----KFirTTDERHKKVVQKIFEKLYEQGDIYKG 121
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
566-645 |
2.35e-08 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 58.27 E-value: 2.35e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 566 SSLGWPNQTEDL-ETFFPNTILETGQDILFF----WVArMVMvSLHLmkKLPfKTIYLHAMIRdSRGEKMSKSKGNVVDP 640
Cdd:PRK12267 237 TALGYGSDDDELfKKFWPADVHLVGKDILRFhaiyWPI-MLM-ALGL--PLP-KKVFAHGWWL-MKDGKMSKSKGNVVDP 310
|
....*
gi 124810112 641 LDIID 645
Cdd:PRK12267 311 EELVD 315
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
553-645 |
8.56e-08 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 56.04 E-value: 8.56e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 553 VLDTWFSSSLVPFSSLGWPNQTEDLET----FFPNTILETGQDILFF----WVArMVMvSLHLmkKLPfKTIYLHAMIRD 624
Cdd:PRK11893 221 VIYVWFDALTNYLTALGYPDDEELLAElfnkYWPADVHLIGKDILRFhavyWPA-FLM-AAGL--PLP-KRVFAHGFLTL 295
|
90 100
....*....|....*....|.
gi 124810112 625 sRGEKMSKSKGNVVDPLDIID 645
Cdd:PRK11893 296 -DGEKMSKSLGNVIDPFDLVD 315
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
81-233 |
3.62e-07 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 54.35 E-value: 3.62e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 81 KKFVIILPPPNVTGTLHIGHTLTVAIQDSLVRYKRMKNYLTLYIPGTD-H----------AGIATQTVVEKMlykkeNKI 149
Cdd:COG0143 1 KKFLVTTAIPYANGPPHIGHLYTYIPADILARYQRLRGHDVLFVTGTDeHgtkielaaekEGITPQELVDRI-----HAE 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 150 RQDYgreefvkkiyeWKDLHgnkINNQmkrigasvDWSReyfTMNENLSNAVKEAFIKFYESGLIYRDNRLVAWCPHLKT 229
Cdd:COG0143 76 FKEL-----------FEKLG---ISFD--------NFIR---TTSPEHKELVQEIFQRLYDNGDIYKGEYEGWYCPECER 130
|
....
gi 124810112 230 ALSD 233
Cdd:COG0143 131 FLPD 134
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
566-645 |
1.50e-05 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 48.96 E-value: 1.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 566 SSLGWPNQT---EDLETFFPNTILET----GQDILFF----WVArMVMvSLHLmkKLPfKTIYLHAMIrDSRGEKMSKSK 634
Cdd:COG0143 259 ATKGYADDRglpEDFEKYWPAPDTELvhfiGKDIIRFhaiiWPA-MLM-AAGL--PLP-KKVFAHGFL-TVEGEKMSKSR 332
|
90
....*....|.
gi 124810112 635 GNVVDPLDIID 645
Cdd:COG0143 333 GNVIDPDDLLD 343
|
|
| Anticodon_Ia_like |
cd07375 |
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This ... |
708-807 |
4.01e-05 |
|
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This domain is found in a variety of class Ia aminoacyl tRNA synthetases, C-terminal to the catalytic core domain. It recognizes and specifically binds to the anticodon of the tRNA. Aminoacyl tRNA synthetases catalyze the transfer of cognate amino acids to the 3'-end of their tRNAs by specifically recognizing cognate from non-cognate amino acids. Members include valyl-, leucyl-, isoleucyl-, cysteinyl-, arginyl-, and methionyl-tRNA synthethases. This superfamily also includes a domain from MshC, an enzyme in the mycothiol biosynthetic pathway.
Pssm-ID: 153408 [Multi-domain] Cd Length: 117 Bit Score: 44.03 E-value: 4.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 708 NRIIGYRHFCNKLWNAVKFFLKtlpdnydnyNILIDKPEYV-EKLQWEDKWILHKLNVYIKNANDNFESYNFSEVAFASY 786
Cdd:cd07375 2 ERLKQARAFLNRLYRLLSFFRK---------ALGGTQPKWDnELLEEADRELLARLQEFIKRTTNALEALDPTTAVQELF 72
|
90 100
....*....|....*....|.
gi 124810112 787 NFWLYDlcDIYLELIKPRLNT 807
Cdd:cd07375 73 KFTNEL--NWYLDELKPALQT 91
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
607-645 |
5.80e-05 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 46.47 E-value: 5.80e-05
10 20 30
....*....|....*....|....*....|....*....
gi 124810112 607 LMKKLPFKTIYLHAMIRdSRGEKMSKSKGNVVDPLDIID 645
Cdd:cd00812 254 LVTDEPPKGLIVQGMVL-LEGEKMSKSKGNVVTPDEAIK 291
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
87-164 |
3.22e-04 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 44.76 E-value: 3.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 87 LPPPNvtGTLHIGHTLTVaIQ-DSLVRYKRMKNYLTLYIPGTD-H----------AGIATQTVVEKmlYKKENK------ 148
Cdd:PRK00133 10 LPYAN--GPIHLGHLVEY-IQaDIWVRYQRMRGHEVLFVCADDaHgtpimlkaekEGITPEELIAR--YHAEHKrdfagf 84
|
90 100
....*....|....*....|....*...
gi 124810112 149 -IRQD-YGR----------EEFVKKIYE 164
Cdd:PRK00133 85 gISFDnYGSthseenrelaQEIYLKLKE 112
|
|
| PLN02224 |
PLN02224 |
methionine-tRNA ligase |
550-644 |
1.92e-03 |
|
methionine-tRNA ligase
Pssm-ID: 177869 [Multi-domain] Cd Length: 616 Bit Score: 42.39 E-value: 1.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 550 DEDVLDTWFSSSLVPFSSLGWPNQTEDLETF----FPNTILETGQDILFF----WVARMVMVSLhlmkKLPfKTIYLHAM 621
Cdd:PLN02224 285 DKQTIYVWFDALLGYISALTEDNKQQNLETAvsfgWPASLHLIGKDILRFhavyWPAMLMSAGL----ELP-KMVFGHGF 359
|
90 100
....*....|....*....|...
gi 124810112 622 IRDSrGEKMSKSKGNVVDPLDII 644
Cdd:PLN02224 360 LTKD-GMKMGKSLGNTLEPFELV 381
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
604-645 |
2.10e-03 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 41.36 E-value: 2.10e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810112 604 SLHLMKK--LPFKTIYLHAMIRDSR----------------GEKMSKSKGNVVDPLDIID 645
Cdd:cd00814 237 LVHFIGKdiIRFHAIYWPAMLLGAGlplptrivahgyltveGKKMSKSRGNVVDPDDLLE 296
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
588-645 |
2.38e-03 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 41.51 E-value: 2.38e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 124810112 588 TGQDILF--FWVARMVMVSLHLMKK--LPFKTIYLHAMIRDSR----------------GEKMSKSKGNVVDPLDIID 645
Cdd:pfam09334 263 SGNEEKWkeWWPNDPDTELVHFIGKdiIYFHTIFWPAMLLGAGyrlpttvfahgyltyeGGKMSKSRGNVVWPSEALD 340
|
|
| Anticodon_Ia_Leu_AEc |
cd07959 |
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ... |
741-808 |
4.18e-03 |
|
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153413 [Multi-domain] Cd Length: 117 Bit Score: 38.34 E-value: 4.18e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 124810112 741 LIDKPEYVEKLQWEDKWILHKLNVYIKNANDNFESYNFSEVAFASYnFWLYDLCDIYLELIKPRLNTD 808
Cdd:cd07959 23 LIETEGELEELTFIDRWLLSRLNRLIKETTEAYENMQFREALKEGL-YELQNDLDWYRERGGAGMNKD 89
|
|
| |
