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Conserved domains on  [gi|124810146|ref|XP_001348779|]
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cyclin 1 [Plasmodium falciparum 3D7]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_CCNH_rpt1 cd20524
first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ...
 5-147 3.77e-36

first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410228  Cd Length: 150  Bit Score: 127.71  E-value: 3.77e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810146   5 EDTTHMKKWFFKSRKEIDNICLKKYNDFKEEFKDY------NIKIPKYNDVEKTKVYFCYQLVHFCEIKMLRPHIVECAT 78
Cdd:cd20524    1 HTSTQRKHWIFSSEEELAELRAEANEKAREKLKESlkeedaEPKFLTPEEELLLVRYYEKKLLEFCRAFKLPDSVLATAL 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 124810146  79 ILYNRFYLKEIILEYDPRILIFTCIVLAIKIEGYgrLYKINEFFNDI---DINLDKVLEHENIVCSSLNFEL 147
Cdd:cd20524   81 TYFKRFYLKNSVMEYHPKEIMLTCLYLACKVEEF--NISIDQFVGNIkesEKTAEIILEYELLLLQGLNFHL 150
 
Name Accession Description Interval E-value
CYCLIN_CCNH_rpt1 cd20524
first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ...
 5-147 3.77e-36

first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410228  Cd Length: 150  Bit Score: 127.71  E-value: 3.77e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810146   5 EDTTHMKKWFFKSRKEIDNICLKKYNDFKEEFKDY------NIKIPKYNDVEKTKVYFCYQLVHFCEIKMLRPHIVECAT 78
Cdd:cd20524    1 HTSTQRKHWIFSSEEELAELRAEANEKAREKLKESlkeedaEPKFLTPEEELLLVRYYEKKLLEFCRAFKLPDSVLATAL 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 124810146  79 ILYNRFYLKEIILEYDPRILIFTCIVLAIKIEGYgrLYKINEFFNDI---DINLDKVLEHENIVCSSLNFEL 147
Cdd:cd20524   81 TYFKRFYLKNSVMEYHPKEIMLTCLYLACKVEEF--NISIDQFVGNIkesEKTAEIILEYELLLLQGLNFHL 150
ccl1 TIGR00569
cyclin ccl1; All proteins in this family for which functions are known are cyclins that are ...
 55-216 5.64e-10

cyclin ccl1; All proteins in this family for which functions are known are cyclins that are components of TFIIH, a complex that is involved in nucleotide excision repair and transcription initiation. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, StanfordUniversity). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129660 [Multi-domain]  Cd Length: 305  Bit Score: 59.46  E-value: 5.64e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810146   55 YFCYQLVHFCEI--KMLRPHIVECATILYNRFYLKEIILEYDPRILIFTCIVLAIKIEGYGrlYKINEFFNDIDIN---- 128
Cdd:TIGR00569  58 YYEKRLLDFCSAfkPTMPTSVVGTAIMYFKRFYLNNSVMEYHPKIIMLTCVFLACKVEEFN--VSIDQFVGNLKETplka 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810146  129 LDKVLEHENIVCSSLNFEL----------NFLYTKECIFYIKsQFEKYINKYILEadkidnsmetiinticfnaskdciK 198
Cdd:TIGR00569 136 LEQVLEYELLLIQQLNFHLivhnpyrpleGFLIDIKTRLPGL-ENPEYLRKHADK------------------------F 190

                         170       180
                  ....*....|....*....|
gi 124810146  199 LIENFYT--TFIYTPSQIAL 216
Cdd:TIGR00569 191 LNRTLLTdaYLLYTPSQIAL 210
CCL1 COG5333
Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision ...
 46-219 2.34e-06

Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair];


Pssm-ID: 227640 [Multi-domain]  Cd Length: 297  Bit Score: 48.19  E-value: 2.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810146  46 YNDVEKTKVYFCYQLVHFCEIKMLRPHIVECATILYNRFYLKEIILEYDPRILIFTCIVLAIKIEgygrlykinEFFNDI 125
Cdd:COG5333   38 LEKELNLVIYYLKLIMDLCTRLNLPQTVLATAILFFSRFYLKNSVEEISLYSVVTTCVYLACKVE---------DTPRDI 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810146 126 DINL---------------DKVLEHENIVCSSLNFELNF--LYTKECIFYIKSQFEKYINKYileadkidnsmetiinTI 188
Cdd:COG5333  109 SIESfeardlwseepkssrERILEYEFELLEALDFDLHVhhPYKYLEGFLKDLQEKDKYKLL----------------QI 172

                        170       180       190
                 ....*....|....*....|....*....|.
gi 124810146 189 CFNASKDCIKLIenfyTTFIYTPSQIALYCF 219
Cdd:COG5333  173 AWKIINDALRTD----LCLLYPPHIIALAAL 199
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 60-114 1.84e-04

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 39.50  E-value: 1.84e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 124810146    60 LVHFCEIKMLRPHIVECATILYNRFYLKEIILEYDPRILIFTCIVLAIKIEGYGR 114
Cdd:smart00385   3 LRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPP 57
 
Name Accession Description Interval E-value
CYCLIN_CCNH_rpt1 cd20524
first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ...
 5-147 3.77e-36

first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410228  Cd Length: 150  Bit Score: 127.71  E-value: 3.77e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810146   5 EDTTHMKKWFFKSRKEIDNICLKKYNDFKEEFKDY------NIKIPKYNDVEKTKVYFCYQLVHFCEIKMLRPHIVECAT 78
Cdd:cd20524    1 HTSTQRKHWIFSSEEELAELRAEANEKAREKLKESlkeedaEPKFLTPEEELLLVRYYEKKLLEFCRAFKLPDSVLATAL 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 124810146  79 ILYNRFYLKEIILEYDPRILIFTCIVLAIKIEGYgrLYKINEFFNDI---DINLDKVLEHENIVCSSLNFEL 147
Cdd:cd20524   81 TYFKRFYLKNSVMEYHPKEIMLTCLYLACKVEEF--NISIDQFVGNIkesEKTAEIILEYELLLLQGLNFHL 150
ccl1 TIGR00569
cyclin ccl1; All proteins in this family for which functions are known are cyclins that are ...
 55-216 5.64e-10

cyclin ccl1; All proteins in this family for which functions are known are cyclins that are components of TFIIH, a complex that is involved in nucleotide excision repair and transcription initiation. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, StanfordUniversity). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129660 [Multi-domain]  Cd Length: 305  Bit Score: 59.46  E-value: 5.64e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810146   55 YFCYQLVHFCEI--KMLRPHIVECATILYNRFYLKEIILEYDPRILIFTCIVLAIKIEGYGrlYKINEFFNDIDIN---- 128
Cdd:TIGR00569  58 YYEKRLLDFCSAfkPTMPTSVVGTAIMYFKRFYLNNSVMEYHPKIIMLTCVFLACKVEEFN--VSIDQFVGNLKETplka 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810146  129 LDKVLEHENIVCSSLNFEL----------NFLYTKECIFYIKsQFEKYINKYILEadkidnsmetiinticfnaskdciK 198
Cdd:TIGR00569 136 LEQVLEYELLLIQQLNFHLivhnpyrpleGFLIDIKTRLPGL-ENPEYLRKHADK------------------------F 190

                         170       180
                  ....*....|....*....|
gi 124810146  199 LIENFYT--TFIYTPSQIAL 216
Cdd:TIGR00569 191 LNRTLLTdaYLLYTPSQIAL 210
CYCLIN_AcCycH_rpt1 cd20585
first cyclin box found in Arabidopsis thaliana H-type cyclin (CycH) and similar proteins; CycH ...
 55-147 3.50e-09

first cyclin box found in Arabidopsis thaliana H-type cyclin (CycH) and similar proteins; CycH associates with and activates the cyclin-dependent kinases, CDK-2 and CDK-3. CycH contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410288  Cd Length: 170  Bit Score: 55.22  E-value: 3.50e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810146  55 YFCYQLVHFC-EIKMlrPHIVECATILY-NRFYLKEIILEYDPRILIFTCIVLAIKIEGYgrLYKINEFFNDIDINLDKV 132
Cdd:cd20585   80 YYEQKIQEVCrALRL--PNKIQATALLYfKRFYLQWSVMEHDPKRIMLTCIYLACKVEEY--HVSAEELGKGIQQDHQLI 155

                         90
                 ....*....|....*
gi 124810146 133 LEHENIVCSSLNFEL 147
Cdd:cd20585  156 LKNELALLQGLNFDL 170
CCL1 COG5333
Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision ...
 46-219 2.34e-06

Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair];


Pssm-ID: 227640 [Multi-domain]  Cd Length: 297  Bit Score: 48.19  E-value: 2.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810146  46 YNDVEKTKVYFCYQLVHFCEIKMLRPHIVECATILYNRFYLKEIILEYDPRILIFTCIVLAIKIEgygrlykinEFFNDI 125
Cdd:COG5333   38 LEKELNLVIYYLKLIMDLCTRLNLPQTVLATAILFFSRFYLKNSVEEISLYSVVTTCVYLACKVE---------DTPRDI 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124810146 126 DINL---------------DKVLEHENIVCSSLNFELNF--LYTKECIFYIKSQFEKYINKYileadkidnsmetiinTI 188
Cdd:COG5333  109 SIESfeardlwseepkssrERILEYEFELLEALDFDLHVhhPYKYLEGFLKDLQEKDKYKLL----------------QI 172

                        170       180       190
                 ....*....|....*....|....*....|.
gi 124810146 189 CFNASKDCIKLIenfyTTFIYTPSQIALYCF 219
Cdd:COG5333  173 AWKIINDALRTD----LCLLYPPHIIALAAL 199
CYCLIN_CCNC_rpt1 cd20513
first cyclin box found in cyclin-C (CCNC) and similar proteins; CCNC, also termed CycC, or ...
 53-110 2.81e-06

first cyclin box found in cyclin-C (CCNC) and similar proteins; CCNC, also termed CycC, or SRB11, is a component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. It mediates stress-induced mitochondrial fission and apoptosis. CCNC contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410217 [Multi-domain]  Cd Length: 101  Bit Score: 45.28  E-value: 2.81e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 124810146  53 KVYFCYQLVHFCEIKMLRPHIVECATILYNRFYLKEIILEYDPRILIFTCIVLAIKIE 110
Cdd:cd20513    2 HIFFANFIQALGERLKLRQRVIATAIVYFKRFYARNSFKDIDPRLVAPTCLYLASKVE 59
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 60-138 1.01e-05

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 43.17  E-value: 1.01e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 124810146  60 LVHFCEIKMLRPHIVECATILYNRFYLKEIILEYDPRILIFTCIVLAIKIEGYGRlyKINEFFNDIDINLDKVLEHENI 138
Cdd:cd00043    6 IRRLCSKLGLPEEVLELAIELLDRFLSKGLLLGRSPELIAAACLYLACKLEELPR--TLKEIAKVSGVSEKELRKAEKE 82
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 60-114 1.84e-04

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 39.50  E-value: 1.84e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 124810146    60 LVHFCEIKMLRPHIVECATILYNRFYLKEIILEYDPRILIFTCIVLAIKIEGYGR 114
Cdd:smart00385   3 LRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPP 57
CYCLIN_CCNL_rpt1 cd20532
first cyclin box found in cyclin-L (CCNL) family; The CCNL family includes two cyclins, CCNL1 ...
 69-114 4.25e-03

first cyclin box found in cyclin-L (CCNL) family; The CCNL family includes two cyclins, CCNL1 and CCNL2. CCNL1 is involved in the regulation of RNA polymerase II (pol II) transcription. It functions in association with cyclin-dependent kinases (CDKs). CCNL2 is a novel RNA polymerase II-associated cyclin involved in pre-mRNA splicing. It may induce cell death, possibly by acting on the transcription and RNA processing of apoptosis-related factors. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410235 [Multi-domain]  Cd Length: 127  Bit Score: 36.77  E-value: 4.25e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 124810146  69 LRPHIVECAT--ILYNRFYLKEIILEYDPRILIFTCIVLAIKIEGYGR 114
Cdd:cd20532   26 LKLPQVVMATaqVLFHRFYYRKSLRKFDVKIVAMACLFLASKIEETPR 73
CYCLIN_CCNM_CCNQ_rpt1 cd20534
first cyclin box found in cyclin-M (CCNM) family; The CCNM family proteins, also called ...
 76-110 8.33e-03

first cyclin box found in cyclin-M (CCNM) family; The CCNM family proteins, also called ancient conserved domain proteins (ACDPs), are evolutionarily conserved Mg2+ transporters. CCNM, also called cyclin-Q (CCNQ), or CDK10-activating cyclin, or cyclin-related protein FAM58A, associates with CDK10 to promote its kinase activity. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410237 [Multi-domain]  Cd Length: 110  Bit Score: 35.61  E-value: 8.33e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 124810146  76 CATILYNRFYLKEIILEYDPRILIFTCIVLAIKIE 110
Cdd:cd20534   25 TACVLYHRFYRELSLEDYDPYLVAMACLYLAGKAE 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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