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Conserved domains on  [gi|124512250|ref|XP_001349258|]
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receptor for activated c kinase [Plasmodium falciparum 3D7]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 19-317 1.11e-80

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 246.86  E-value: 1.11e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512250  19 GHSDWVTSVSTptDPKLKTIVSASRDKKLIVWNINTdddsgeiGTAKKSLTGHSQAINDVSISSDGLFALSGSWDHSVRL 98
Cdd:cd00200    7 GHTGGVTCVAF--SPDGKLLATGSGDGTIKVWDLET-------GELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512250  99 WDLSLGETIRSFIGHTSDVFSVSFSPDNRQIVSASRDKTIKLWNTL-AQCKYTITDqqHTDWITCVRFspSPNQAIIVSC 177
Cdd:cd00200   78 WDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVEtGKCLTTLRG--HTDWVNSVAF--SPDGTFVASS 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512250 178 GWDKLVKVWNLKNCDLNKNLEGHTGVLNTVTISPDGSLCASGGKDGVAKLWDVKEGKHLYSLET-GSTINSLCFSPCDYW 256
Cdd:cd00200  154 SQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAFSPDGYL 233

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 124512250 257 LCAAT-DRFIRIWNLESKLIISEIYPVKQSkigvpwCTSLTWSANGQLLYCGSTDGNIYVYE 317
Cdd:cd00200  234 LASGSeDGTIRVWDLRTGECVQTLSGHTNS------VTSLAWSPDGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 19-317 1.11e-80

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 246.86  E-value: 1.11e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512250  19 GHSDWVTSVSTptDPKLKTIVSASRDKKLIVWNINTdddsgeiGTAKKSLTGHSQAINDVSISSDGLFALSGSWDHSVRL 98
Cdd:cd00200    7 GHTGGVTCVAF--SPDGKLLATGSGDGTIKVWDLET-------GELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512250  99 WDLSLGETIRSFIGHTSDVFSVSFSPDNRQIVSASRDKTIKLWNTL-AQCKYTITDqqHTDWITCVRFspSPNQAIIVSC 177
Cdd:cd00200   78 WDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVEtGKCLTTLRG--HTDWVNSVAF--SPDGTFVASS 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512250 178 GWDKLVKVWNLKNCDLNKNLEGHTGVLNTVTISPDGSLCASGGKDGVAKLWDVKEGKHLYSLET-GSTINSLCFSPCDYW 256
Cdd:cd00200  154 SQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAFSPDGYL 233

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 124512250 257 LCAAT-DRFIRIWNLESKLIISEIYPVKQSkigvpwCTSLTWSANGQLLYCGSTDGNIYVYE 317
Cdd:cd00200  234 LASGSeDGTIRVWDLRTGECVQTLSGHTNS------VTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
19-319 3.39e-76

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 239.04  E-value: 3.39e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512250  19 GHSDWVTSVSTptDPKLKTIVSASRDKKLIVWNINTdddsgeiGTAKKSLTGHSQAINDVSISSDGLFALSGSWDHSVRL 98
Cdd:COG2319  118 GHTGAVRSVAF--SPDGKTLASGSADGTVRLWDLAT-------GKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRL 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512250  99 WDLSLGETIRSFIGHTSDVFSVSFSPDNRQIVSASRDKTIKLWNtLAQCKYTITDQQHTDWITCVRFspSPNQAIIVSCG 178
Cdd:COG2319  189 WDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWD-LATGKLLRTLTGHSGSVRSVAF--SPDGRLLASGS 265

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512250 179 WDKLVKVWNLKNCDLNKNLEGHTGVLNTVTISPDGSLCASGGKDGVAKLWDVKEGKHLYSLE-TGSTINSLCFSPCDYWL 257
Cdd:COG2319  266 ADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTL 345

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 124512250 258 CAAT-DRFIRIWNLESKLIISEIYPVKQskigvpWCTSLTWSANGQLLYCGSTDGNIYVYEVK 319
Cdd:COG2319  346 ASGSdDGTVRLWDLATGELLRTLTGHTG------AVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 104-142 1.38e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.00  E-value: 1.38e-08
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 124512250   104 GETIRSFIGHTSDVFSVSFSPDNRQIVSASRDKTIKLWN 142
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
104-142 2.53e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 49.27  E-value: 2.53e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 124512250  104 GETIRSFIGHTSDVFSVSFSPDNRQIVSASRDKTIKLWN 142
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 111-241 5.96e-07

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 50.66  E-value: 5.96e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512250 111 IGHTSDVFSVSFSP-DNRQIVSASRDKTIKLWNTLAQ-CKYTITD-----QQHTDWITCVRFSPSPNqAIIVSCGWDKLV 183
Cdd:PTZ00421  72 LGQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGIPEEgLTQNISDpivhlQGHTKKVGIVSFHPSAM-NVLASAGADMVV 150

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 124512250 184 KVWNLKNCDLNKNLEGHTGVLNTVTISPDGSLCASGGKDGVAKLWDVKEGKHLYSLET 241
Cdd:PTZ00421 151 NVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEA 208
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 19-317 1.11e-80

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 246.86  E-value: 1.11e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512250  19 GHSDWVTSVSTptDPKLKTIVSASRDKKLIVWNINTdddsgeiGTAKKSLTGHSQAINDVSISSDGLFALSGSWDHSVRL 98
Cdd:cd00200    7 GHTGGVTCVAF--SPDGKLLATGSGDGTIKVWDLET-------GELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512250  99 WDLSLGETIRSFIGHTSDVFSVSFSPDNRQIVSASRDKTIKLWNTL-AQCKYTITDqqHTDWITCVRFspSPNQAIIVSC 177
Cdd:cd00200   78 WDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVEtGKCLTTLRG--HTDWVNSVAF--SPDGTFVASS 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512250 178 GWDKLVKVWNLKNCDLNKNLEGHTGVLNTVTISPDGSLCASGGKDGVAKLWDVKEGKHLYSLET-GSTINSLCFSPCDYW 256
Cdd:cd00200  154 SQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAFSPDGYL 233

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 124512250 257 LCAAT-DRFIRIWNLESKLIISEIYPVKQSkigvpwCTSLTWSANGQLLYCGSTDGNIYVYE 317
Cdd:cd00200  234 LASGSeDGTIRVWDLRTGECVQTLSGHTNS------VTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
19-319 3.39e-76

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 239.04  E-value: 3.39e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512250  19 GHSDWVTSVSTptDPKLKTIVSASRDKKLIVWNINTdddsgeiGTAKKSLTGHSQAINDVSISSDGLFALSGSWDHSVRL 98
Cdd:COG2319  118 GHTGAVRSVAF--SPDGKTLASGSADGTVRLWDLAT-------GKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRL 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512250  99 WDLSLGETIRSFIGHTSDVFSVSFSPDNRQIVSASRDKTIKLWNtLAQCKYTITDQQHTDWITCVRFspSPNQAIIVSCG 178
Cdd:COG2319  189 WDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWD-LATGKLLRTLTGHSGSVRSVAF--SPDGRLLASGS 265

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512250 179 WDKLVKVWNLKNCDLNKNLEGHTGVLNTVTISPDGSLCASGGKDGVAKLWDVKEGKHLYSLE-TGSTINSLCFSPCDYWL 257
Cdd:COG2319  266 ADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTL 345

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 124512250 258 CAAT-DRFIRIWNLESKLIISEIYPVKQskigvpWCTSLTWSANGQLLYCGSTDGNIYVYEVK 319
Cdd:COG2319  346 ASGSdDGTVRLWDLATGELLRTLTGHTG------AVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
19-272 1.91e-67

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 216.32  E-value: 1.91e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512250  19 GHSDWVTSVS-TPTDpklKTIVSASRDKKLIVWNINTdddsgeiGTAKKSLTGHSQAINDVSISSDGLFALSGSWDHSVR 97
Cdd:COG2319  160 GHSGAVTSVAfSPDG---KLLASGSDDGTVRLWDLAT-------GKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVR 229

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512250  98 LWDLSLGETIRSFIGHTSDVFSVSFSPDNRQIVSASRDKTIKLWNTL-AQCKYTITDqqHTDWITCVRFSPspNQAIIVS 176
Cdd:COG2319  230 LWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAtGELLRTLTG--HSGGVNSVAFSP--DGKLLAS 305

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512250 177 CGWDKLVKVWNLKNCDLNKNLEGHTGVLNTVTISPDGSLCASGGKDGVAKLWDVKEGKHLYSLET-GSTINSLCFSP-CD 254
Cdd:COG2319  306 GSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGhTGAVTSVAFSPdGR 385

                        250
                 ....*....|....*...
gi 124512250 255 YWLCAATDRFIRIWNLES 272
Cdd:COG2319  386 TLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
5-319 8.75e-64

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 207.07  E-value: 8.75e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512250   5 IKEAEISLRGVLEGGHSDWVTSVSTPTDpkLKTIVSASRDKKLIVWNINTdddsgeiGTAKKSLTGHSQAINDVSISSDG 84
Cdd:COG2319   20 LLAAALGALLLLLLGLAAAVASLAASPD--GARLAAGAGDLTLLLLDAAA-------GALLATLLGHTAAVLSVAFSPDG 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512250  85 LFALSGSWDHSVRLWDLSLGETIRSFIGHTSDVFSVSFSPDNRQIVSASRDKTIKLWNTL-AQCKYTITDqqHTDWITCV 163
Cdd:COG2319   91 RLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAtGKLLRTLTG--HSGAVTSV 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512250 164 RFspSPNQAIIVSCGWDKLVKVWNLKNCDLNKNLEGHTGVLNTVTISPDGSLCASGGKDGVAKLWDVKEGKHLYSLET-G 242
Cdd:COG2319  169 AF--SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGhS 246

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 124512250 243 STINSLCFSPCDYWL-CAATDRFIRIWNLESKLIISEIypvkqsKIGVPWCTSLTWSANGQLLYCGSTDGNIYVYEVK 319
Cdd:COG2319  247 GSVRSVAFSPDGRLLaSGSADGTVRLWDLATGELLRTL------TGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA 318
WD40 COG2319
WD40 repeat [General function prediction only];
18-190 1.34e-45

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 159.69  E-value: 1.34e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512250  18 GGHSDWVTSVS-TPTDpklKTIVSASRDKKLIVWNINTdddsgeiGTAKKSLTGHSQAINDVSISSDGLFALSGSWDHSV 96
Cdd:COG2319  243 TGHSGSVRSVAfSPDG---RLLASGSADGTVRLWDLAT-------GELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTV 312

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512250  97 RLWDLSLGETIRSFIGHTSDVFSVSFSPDNRQIVSASRDKTIKLWNtLAQCKYTITDQQHTDWITCVRFSPspNQAIIVS 176
Cdd:COG2319  313 RLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWD-LATGELLRTLTGHTGAVTSVAFSP--DGRTLAS 389

                        170
                 ....*....|....
gi 124512250 177 CGWDKLVKVWNLKN 190
Cdd:COG2319  390 GSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
81-319 1.41e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 130.03  E-value: 1.41e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512250  81 SSDGLFALSGSWDHSVRLWDLSLGETIRSFIGHTSDVFSVSFSPDNRQIVSASRDKTIKLWNTLAQcKYTITDQQHTDWI 160
Cdd:COG2319    3 SADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAG-ALLATLLGHTAAV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512250 161 TCVRFSP----------------------------------------SPNQAIIVSCGWDKLVKVWNLKNCDLNKNLEGH 200
Cdd:COG2319   82 LSVAFSPdgrllasasadgtvrlwdlatglllrtltghtgavrsvafSPDGKTLASGSADGTVRLWDLATGKLLRTLTGH 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512250 201 TGVLNTVTISPDGSLCASGGKDGVAKLWDVKEGKHLYSLE-TGSTINSLCFSPCDYWL-CAATDRFIRIWNLESKLIISE 278
Cdd:COG2319  162 SGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKLLaSGSADGTVRLWDLATGKLLRT 241

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 124512250 279 IypvkqsKIGVPWCTSLTWSANGQLLYCGSTDGNIYVYEVK 319
Cdd:COG2319  242 L------TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA 276
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 107-323 1.27e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 117.05  E-value: 1.27e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512250 107 IRSFIGHTSDVFSVSFSPDNRQIVSASRDKTIKLWNtLAQCKYTITDQQHTDWITCVRFSPSPNQaiIVSCGWDKLVKVW 186
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWD-LETGELLRTLKGHTGPVRDVAASADGTY--LASGSSDKTIRLW 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512250 187 NLKNCDLNKNLEGHTGVLNTVTISPDGSLCASGGKDGVAKLWDVKEGKHLYSLET-GSTINSLCFSPcdywlcaatdrfi 265
Cdd:cd00200   79 DLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGhTDWVNSVAFSP------------- 145

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 124512250 266 riwnleskliiseiypvkqskigvpwctsltwsaNGQLLYCGSTDGNIYVYEVKKHSV 323
Cdd:cd00200  146 ----------------------------------DGTFVASSSQDGTIKLWDLRTGKC 169
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 104-142 1.38e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.00  E-value: 1.38e-08
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 124512250   104 GETIRSFIGHTSDVFSVSFSPDNRQIVSASRDKTIKLWN 142
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
104-142 2.53e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 49.27  E-value: 2.53e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 124512250  104 GETIRSFIGHTSDVFSVSFSPDNRQIVSASRDKTIKLWN 142
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 111-241 5.96e-07

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 50.66  E-value: 5.96e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512250 111 IGHTSDVFSVSFSP-DNRQIVSASRDKTIKLWNTLAQ-CKYTITD-----QQHTDWITCVRFSPSPNqAIIVSCGWDKLV 183
Cdd:PTZ00421  72 LGQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGIPEEgLTQNISDpivhlQGHTKKVGIVSFHPSAM-NVLASAGADMVV 150

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 124512250 184 KVWNLKNCDLNKNLEGHTGVLNTVTISPDGSLCASGGKDGVAKLWDVKEGKHLYSLET 241
Cdd:PTZ00421 151 NVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEA 208
WD40 pfam00400
WD domain, G-beta repeat;
62-100 7.02e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.03  E-value: 7.02e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 124512250   62 GTAKKSLTGHSQAINDVSISSDGLFALSGSWDHSVRLWD 100
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 62-100 2.05e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 2.05e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 124512250    62 GTAKKSLTGHSQAINDVSISSDGLFALSGSWDHSVRLWD 100
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 23-142 1.09e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 47.00  E-value: 1.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512250  23 WVTSVSTpTDPKLktIVSASRDKKLIVWNINTDDDSGEIGTAKKsltghsqaINDVSISSDGLFALS-GSWDHSVRLWDL 101
Cdd:PLN00181 579 WSIDYSS-ADPTL--LASGSDDGSVKLWSINQGVSIGTIKTKAN--------ICCVQFPSESGRSLAfGSADHKVYYYDL 647

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 124512250 102 SLGET-IRSFIGHTSDVFSVSFSpDNRQIVSASRDKTIKLWN 142
Cdd:PLN00181 648 RNPKLpLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWD 688
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 89-230 2.34e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.85  E-value: 2.34e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512250  89 SGSWDHSVRLWDLSLGETIRSFIGHTSDVFSVSFSP-DNRQIVSASRDKTIKLWNTLAQCKY-TITDQQHtdwITCVRFs 166
Cdd:PLN00181 550 SSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIgTIKTKAN---ICCVQF- 625

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 124512250 167 PSPNQAIIVSCGWDKLVKVWNLKNCDLNK-NLEGHTGVLNTVTISpDGSLCASGGKDGVAKLWDV 230
Cdd:PLN00181 626 PSESGRSLAFGSADHKVYYYDLRNPKLPLcTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDL 689
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 195-229 2.91e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 2.91e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 124512250   195 KNLEGHTGVLNTVTISPDGSLCASGGKDGVAKLWD 229
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
195-229 3.08e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 3.08e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 124512250  195 KNLEGHTGVLNTVTISPDGSLCASGGKDGVAKLWD 229
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 100-255 3.83e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.46  E-value: 3.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512250 100 DLSLGETIRSfighTSDVFSVSFSPDNRQIVSASRDKTIKLWntlaQCKYTITDQQHTDWITCVRFSPSPNQAI------ 173
Cdd:PLN00181 473 DLKQGDLLNS----SNLVCAIGFDRDGEFFATAGVNKKIKIF----ECESIIKDGRDIHYPVVELASRSKLSGIcwnsyi 544

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512250 174 ---IVSCGWDKLVKVWNLKNCDLNKNLEGHTGVLNTVTISP-DGSLCASGGKDGVAKLWDVKEGKHLYSLETGSTI---- 245
Cdd:PLN00181 545 ksqVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKANIccvq 624

                        170
                 ....*....|....*.
gi 124512250 246 ------NSLCFSPCDY 255
Cdd:PLN00181 625 fpsesgRSLAFGSADH 640
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 146-187 5.46e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.99  E-value: 5.46e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 124512250   146 QCKYTITDqqHTDWITCVRFSPSPNqaIIVSCGWDKLVKVWN 187
Cdd:smart00320   3 ELLKTLKG--HTGPVTSVAFSPDGK--YLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
156-187 2.05e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 2.05e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 124512250  156 HTDWITCVRFSPSPNqaIIVSCGWDKLVKVWN 187
Cdd:pfam00400  10 HTGSVTSLAFSPDGK--LLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 30-140 3.81e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 41.80  E-value: 3.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512250  30 PTDP-KLKTivsASRDKKLIVWNINTDDDSGEIGTAKKSLTGHSQAINDVSI--SSDGLFALSGSwDHSVRLWDLSLGET 106
Cdd:PTZ00421  85 PFDPqKLFT---ASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFhpSAMNVLASAGA-DMVVNVWDVERGKA 160

                         90       100       110
                 ....*....|....*....|....*....|....
gi 124512250 107 IRSFIGHTSDVFSVSFSPDNRQIVSASRDKTIKL 140
Cdd:PTZ00421 161 VEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNI 194
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 168-234 1.98e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 39.67  E-value: 1.98e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 124512250  168 SPNQAIIVSCG-WDKLVKVWNLKNCDLNKNLEGHTGVLNTVTISPDGSLCASGGKDGVAKLWDVKEGK 234
Cdd:pfam20426  90 TPSENFLISCGnWENSFQVISLNDGRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVLRGR 157
PTZ00420 PTZ00420
coronin; Provisional
 112-190 2.13e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 39.55  E-value: 2.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512250 112 GHTSDVFSVSFSPDNRQIV-SASRDKTIKLWNTLAQCKYT--ITDQQ-----HTDWITCVRFSPSpNQAIIVSCGWDKLV 183
Cdd:PTZ00420  72 GHTSSILDLQFNPCFSEILaSGSEDLTIRVWEIPHNDESVkeIKDPQcilkgHKKKISIIDWNPM-NYYIMCSSGFDSFV 150


                 ....*..
gi 124512250 184 KVWNLKN 190
Cdd:PTZ00420 151 NIWDIEN 157
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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