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Conserved domains on  [gi|124512794|ref|XP_001349753|]
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deoxyhypusine hydroxylase [Plasmodium falciparum 3D7]

Protein Classification

HEAT repeat domain-containing protein( domain architecture ID 11444215)

HEAT repeat domain-containing protein may function as a scaffold, anchoring and/or adaptor protein

CATH:  1.25.10.110
Gene Ontology:  GO:0005515
PubMed:  35552740|10378263
SCOP:  4001283

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
HEAT COG1413
HEAT repeat [General function prediction only];
78-171 5.82e-13

HEAT repeat [General function prediction only];


:

Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 65.81  E-value: 5.82e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512794  78 DEVINILTYALKNNDSvLLRHEIAYVIGQISNEKCNNILINLLSDENENimVRHEAAEGLAAIGSESNIPVIKKYLNDSS 157
Cdd:COG1413   15 PAAVPALIAALADEDP-DVRAAAARALGRLGDPRAVPALLEALKDPDPE--VRAAAAEALGRIGDPEAVPALIAALKDED 91
                         90
                 ....*....|....
gi 124512794 158 VEVRETCELALSSL 171
Cdd:COG1413   92 PEVRRAAAEALGRL 105
HEAT COG1413
HEAT repeat [General function prediction only];
281-397 8.46e-06

HEAT repeat [General function prediction only];


:

Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 45.00  E-value: 8.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512794 281 RYEALFLLRDMETDTSLNALGEALvKDKSSAIfRHELAFVLGQVLHLNSLKYLLSSLTNvsEHEMVRHEVALALGSLGSl 360
Cdd:COG1413    2 RRAAARALGRLGDPAAVPALIAAL-ADEDPDV-RAAAARALGRLGDPRAVPALLEALKD--PDPEVRAAAAEALGRIGD- 76
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 124512794 361 nlnsdeykiiqEQIIDTLKKYSKDECVVVAESCLVGL 397
Cdd:COG1413   77 -----------PEAVPALIAALKDEDPEVRRAAAEAL 102
 
Name Accession Description Interval E-value
HEAT COG1413
HEAT repeat [General function prediction only];
78-171 5.82e-13

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 65.81  E-value: 5.82e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512794  78 DEVINILTYALKNNDSvLLRHEIAYVIGQISNEKCNNILINLLSDENENimVRHEAAEGLAAIGSESNIPVIKKYLNDSS 157
Cdd:COG1413   15 PAAVPALIAALADEDP-DVRAAAARALGRLGDPRAVPALLEALKDPDPE--VRAAAAEALGRIGDPEAVPALIAALKDED 91
                         90
                 ....*....|....
gi 124512794 158 VEVRETCELALSSL 171
Cdd:COG1413   92 PEVRRAAAEALGRL 105
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
81-169 8.32e-13

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 63.90  E-value: 8.32e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512794   81 INILTYALKNNDSVLLRHEIAYVIGQISNEKCNNILINLLSDENENimVRHEAAEGLAAIGSESNIPVIKKYLNDSSVE- 159
Cdd:pfam13646   1 LPALLQALLRDPDPEVRAAAIRALGRIGDPEAVPALLELLKDEDPA--VRRAAAEALGKIGDPEALPALLELLRDDDDDv 78
                          90
                  ....*....|
gi 124512794  160 VRETCELALS 169
Cdd:pfam13646  79 VRAAAAEALA 88
HEAT COG1413
HEAT repeat [General function prediction only];
281-397 8.46e-06

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 45.00  E-value: 8.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512794 281 RYEALFLLRDMETDTSLNALGEALvKDKSSAIfRHELAFVLGQVLHLNSLKYLLSSLTNvsEHEMVRHEVALALGSLGSl 360
Cdd:COG1413    2 RRAAARALGRLGDPAAVPALIAAL-ADEDPDV-RAAAARALGRLGDPRAVPALLEALKD--PDPEVRAAAAEALGRIGD- 76
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 124512794 361 nlnsdeykiiqEQIIDTLKKYSKDECVVVAESCLVGL 397
Cdd:COG1413   77 -----------PEAVPALIAALKDEDPEVRRAAAEAL 102
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
297-359 3.62e-05

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 41.94  E-value: 3.62e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 124512794  297 LNALGEALVKDKSSAIfRHELAFVLGQVLHLNSLKYLLSSLTnvSEHEMVRHEVALALGSLGS 359
Cdd:pfam13646   1 LPALLQALLRDPDPEV-RAAAIRALGRIGDPEAVPALLELLK--DEDPAVRRAAAEALGKIGD 60
EZ_HEAT smart00567
E-Z type HEAT repeats; Present in subunits of cyanobacterial phycocyanin lyase, and other ...
128-156 3.30e-04

E-Z type HEAT repeats; Present in subunits of cyanobacterial phycocyanin lyase, and other proteins. Probable scaffolding role.


Pssm-ID: 128837 [Multi-domain]  Cd Length: 30  Bit Score: 37.78  E-value: 3.30e-04
                           10        20
                   ....*....|....*....|....*....
gi 124512794   128 MVRHEAAEGLAAIGSESNIPVIKKYLNDS 156
Cdd:smart00567   2 LVRHEAAFALGQLGDEEAVPALIKALEDE 30
 
Name Accession Description Interval E-value
HEAT COG1413
HEAT repeat [General function prediction only];
78-171 5.82e-13

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 65.81  E-value: 5.82e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512794  78 DEVINILTYALKNNDSvLLRHEIAYVIGQISNEKCNNILINLLSDENENimVRHEAAEGLAAIGSESNIPVIKKYLNDSS 157
Cdd:COG1413   15 PAAVPALIAALADEDP-DVRAAAARALGRLGDPRAVPALLEALKDPDPE--VRAAAAEALGRIGDPEAVPALIAALKDED 91
                         90
                 ....*....|....
gi 124512794 158 VEVRETCELALSSL 171
Cdd:COG1413   92 PEVRRAAAEALGRL 105
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
81-169 8.32e-13

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 63.90  E-value: 8.32e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512794   81 INILTYALKNNDSVLLRHEIAYVIGQISNEKCNNILINLLSDENENimVRHEAAEGLAAIGSESNIPVIKKYLNDSSVE- 159
Cdd:pfam13646   1 LPALLQALLRDPDPEVRAAAIRALGRIGDPEAVPALLELLKDEDPA--VRRAAAEALGKIGDPEALPALLELLRDDDDDv 78
                          90
                  ....*....|
gi 124512794  160 VRETCELALS 169
Cdd:pfam13646  79 VRAAAAEALA 88
HEAT COG1413
HEAT repeat [General function prediction only];
78-171 3.44e-12

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 63.49  E-value: 3.44e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512794  78 DEVINILTYALKNNDSvLLRHEIAYVIGQISNEKCNNILINLLSDENENimVRHEAAEGLAAIGSESNIPVIKKYLNDSS 157
Cdd:COG1413   46 PRAVPALLEALKDPDP-EVRAAAAEALGRIGDPEAVPALIAALKDEDPE--VRRAAAEALGRLGDPAAVPALLEALKDPD 122
                         90
                 ....*....|....
gi 124512794 158 VEVRETCELALSSL 171
Cdd:COG1413  123 WEVRRAAARALGRL 136
HEAT COG1413
HEAT repeat [General function prediction only];
96-171 1.63e-10

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 58.49  E-value: 1.63e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 124512794  96 LRHEIAYVIGQISNEKCNNILINLLSDENENimVRHEAAEGLAAIGSESNIPVIKKYLNDSSVEVRETCELALSSL 171
Cdd:COG1413    1 VRRAAARALGRLGDPAAVPALIAALADEDPD--VRAAAARALGRLGDPRAVPALLEALKDPDPEVRAAAAEALGRI 74
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
119-171 7.00e-06

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 44.25  E-value: 7.00e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 124512794  119 LLSDENENimVRHEAAEGLAAIGSESNIPVIKKYLNDSSVEVRETCELALSSL 171
Cdd:pfam13646   8 LLRDPDPE--VRAAAIRALGRIGDPEAVPALLELLKDEDPAVRRAAAEALGKI 58
HEAT COG1413
HEAT repeat [General function prediction only];
281-397 8.46e-06

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 45.00  E-value: 8.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512794 281 RYEALFLLRDMETDTSLNALGEALvKDKSSAIfRHELAFVLGQVLHLNSLKYLLSSLTNvsEHEMVRHEVALALGSLGSl 360
Cdd:COG1413    2 RRAAARALGRLGDPAAVPALIAAL-ADEDPDV-RAAAARALGRLGDPRAVPALLEALKD--PDPEVRAAAAEALGRIGD- 76
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 124512794 361 nlnsdeykiiqEQIIDTLKKYSKDECVVVAESCLVGL 397
Cdd:COG1413   77 -----------PEAVPALIAALKDEDPEVRRAAAEAL 102
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
297-359 3.62e-05

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 41.94  E-value: 3.62e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 124512794  297 LNALGEALVKDKSSAIfRHELAFVLGQVLHLNSLKYLLSSLTnvSEHEMVRHEVALALGSLGS 359
Cdd:pfam13646   1 LPALLQALLRDPDPEV-RAAAIRALGRIGDPEAVPALLELLK--DEDPAVRRAAAEALGKIGD 60
HEAT COG1413
HEAT repeat [General function prediction only];
78-141 3.97e-05

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 43.08  E-value: 3.97e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 124512794  78 DEVINILTYALKNnDSVLLRHEIAYVIGQISNEKCNNILINLLSDENENimVRHEAAEGLAAIG 141
Cdd:COG1413   77 PEAVPALIAALKD-EDPEVRRAAAEALGRLGDPAAVPALLEALKDPDWE--VRRAAARALGRLG 137
HEAT COG1413
HEAT repeat [General function prediction only];
281-397 7.06e-05

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 42.31  E-value: 7.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512794 281 RYEALFLLRDMETDTSLNALGEALvKDKSSAIfRHELAFVLGQVLHLNSLKYLLSSLTnvSEHEMVRHEVALALGSLGSl 360
Cdd:COG1413   33 RAAAARALGRLGDPRAVPALLEAL-KDPDPEV-RAAAAEALGRIGDPEAVPALIAALK--DEDPEVRRAAAEALGRLGD- 107
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 124512794 361 nlnsdeykiiqEQIIDTLKKYSKDECVVVAESCLVGL 397
Cdd:COG1413  108 -----------PAAVPALLEALKDPDWEVRRAAARAL 133
HEAT COG1413
HEAT repeat [General function prediction only];
260-358 9.69e-05

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 41.92  E-value: 9.69e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512794 260 NKKHVNDLIRDLNNEALALknRYEALFLLRDMETDTSLNALGEALvKDKSSAIfRHELAFVLGQVLHLNSLKYLLSSLTN 339
Cdd:COG1413   45 DPRAVPALLEALKDPDPEV--RAAAAEALGRIGDPEAVPALIAAL-KDEDPEV-RRAAAEALGRLGDPAAVPALLEALKD 120
                         90
                 ....*....|....*....
gi 124512794 340 vsEHEMVRHEVALALGSLG 358
Cdd:COG1413  121 --PDWEVRRAAARALGRLG 137
EZ_HEAT smart00567
E-Z type HEAT repeats; Present in subunits of cyanobacterial phycocyanin lyase, and other ...
128-156 3.30e-04

E-Z type HEAT repeats; Present in subunits of cyanobacterial phycocyanin lyase, and other proteins. Probable scaffolding role.


Pssm-ID: 128837 [Multi-domain]  Cd Length: 30  Bit Score: 37.78  E-value: 3.30e-04
                           10        20
                   ....*....|....*....|....*....
gi 124512794   128 MVRHEAAEGLAAIGSESNIPVIKKYLNDS 156
Cdd:smart00567   2 LVRHEAAFALGQLGDEEAVPALIKALEDE 30
HEAT_PBS pfam03130
PBS lyase HEAT-like repeat; This family contains a short bi-helical repeat that is related to ...
129-155 1.07e-03

PBS lyase HEAT-like repeat; This family contains a short bi-helical repeat that is related to pfam02985. Cyanobacteria and red algae harvest light energy using macromolecular complexes known as phycobilisomes (PBS), peripherally attached to the photosynthetic membrane. The major components of PBS are the phycobiliproteins. These heterodimeric proteins are covalently attached to phycobilins: open-chain tetrapyrrole chromophores, which function as the photosynthetic light-harvesting pigments. Phycobiliproteins differ in sequence and in the nature and number of attached phycobilins to each of their subunits. This family includes the lyase enzymes that specifically attach particular phycobilins to apophycobiliprotein subunits. The most comprehensively studied of these is the CpcE/F lyase, which attaches phycocyanobilin (PCB) to the alpha subunit of apophycocyanin. Similarly, MpeU/V attaches phycoerythrobilin to phycoerythrin II, while CpeY/Z is thought to be involved in phycoerythrobilin (PEB) attachment to phycoerythrin (PE) I (PEs I and II differ in sequence and in the number of attached molecules of PEB: PE I has five, PE II has six). All the reactions of the above lyases involve an apoprotein cysteine SH addition to a terminal delta 3,3'-double bond. Such a reaction is not possible in the case of phycoviolobilin (PVB), the phycobilin of alpha-phycoerythrocyanin (alpha-PEC). It is thought that in this case, PCB, not PVB, is first added to apo-alpha-PEC, and is then isomerized to PVB. The addition reaction has been shown to occur in the presence of either of the components of alpha-PEC-PVB lyase PecE or PecF (or both). The isomerization reaction occurs only when both PecE and PecF components are present, i.e. the PecE/F phycobiliprotein lyase is also a phycobilin isomerase. Another member of this family is the NblB protein, whose similarity to the phycobiliprotein lyases was previously noted. This constitutively expressed protein is not known to have any lyase activity. It is thought to be involved in the coordination of PBS degradation with environmental nutrient limitation. It has been suggested that the similarity of NblB to the phycobiliprotein lyases is due to the ability to bind tetrapyrrole phycobilins via the common repeated motif.


Pssm-ID: 308641 [Multi-domain]  Cd Length: 27  Bit Score: 36.30  E-value: 1.07e-03
                          10        20
                  ....*....|....*....|....*..
gi 124512794  129 VRHEAAEGLAAIGSESNIPVIKKYLND 155
Cdd:pfam03130   1 VRRAAARALGALGDPEAIPALIEALDD 27
EZ_HEAT smart00567
E-Z type HEAT repeats; Present in subunits of cyanobacterial phycocyanin lyase, and other ...
94-123 1.54e-03

E-Z type HEAT repeats; Present in subunits of cyanobacterial phycocyanin lyase, and other proteins. Probable scaffolding role.


Pssm-ID: 128837 [Multi-domain]  Cd Length: 30  Bit Score: 35.85  E-value: 1.54e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 124512794    94 VLLRHEIAYVIGQISNEKCNNILINLLSDE 123
Cdd:smart00567   1 PLVRHEAAFALGQLGDEEAVPALIKALEDE 30
HEAT COG1413
HEAT repeat [General function prediction only];
129-323 2.16e-03

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 38.07  E-value: 2.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512794 129 VRHEAAEGLAAIGSESNIPVIKKYLNDSSVEVRETCELALSSLieKNKYAacscinktVPYKNNVLNNDNPkrdsnnnsn 208
Cdd:COG1413    1 VRRAAARALGRLGDPAAVPALIAALADEDPDVRAAAARALGRL--GDPRA--------VPALLEALKDPDP--------- 61
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512794 209 nnnnnninnnnsnshsnsfsnsqddaddDVYFHSkkkfntidpVVCISDSNNKKHVNDLIRDLNNEALALknRYEALFLL 288
Cdd:COG1413   62 ----------------------------EVRAAA---------AEALGRIGDPEAVPALIAALKDEDPEV--RRAAAEAL 102
                        170       180       190
                 ....*....|....*....|....*....|....*
gi 124512794 289 RDMETDTSLNALGEALvKDKSSAIfRHELAFVLGQ 323
Cdd:COG1413  103 GRLGDPAAVPALLEAL-KDPDWEV-RRAAARALGR 135
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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