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Conserved domains on  [gi|195110797|ref|XP_001999966|]
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xaa-Pro dipeptidase [Drosophila mojavensis]

Protein Classification

aminopeptidase P family protein( domain architecture ID 10659798)

aminopeptidase family protein P (peptidase M24) cleaves amido-, imido- or amidino-containing bonds, exhibiting a fairly narrow substrate specificity compared to other metallo-aminopeptidases, possibly playing roles in regulation of biological processes

CATH:  3.40.350.10|3.90.230.10
EC:  3.4.11.-
Gene Ontology:  GO:0004177|GO:0016020|GO:0070006|GO:0046872|GO:0006508
MEROPS:  M24
PubMed:  30066404|9434107|12475202

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Prolidase cd01087
Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline ...
 195-468 8.03e-120

Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.


:

Pssm-ID: 238520 [Multi-domain]  Cd Length: 243  Bit Score: 350.72  E-value: 8.03e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195110797 195 IEVLRYVAKVSSDAHIKVMQFIRPGRMEYEGESLFLHHAYAVGGCRHASYTCICGSgiNSAILHYGHagapNNRPIQDGE 274
Cdd:cd01087    1 IELMRKACDISAEAHRAAMKASRPGMSEYELEAEFEYEFRSRGARLAYSYIVAAGS--NAAILHYVH----NDQPLKDGD 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195110797 275 MCLFDMGANYCGYAADITCSFPANGKFTEDQKFIYNAVLAARNAVMETARDGVSWVNMHKLAGKVLLEQLKAGGMLTGDV 354
Cdd:cd01087   75 LVLIDAGAEYGGYASDITRTFPVNGKFTDEQRELYEAVLAAQKAAIAACKPGVSYEDIHLLAHRVLAEGLKELGILKGDV 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195110797 355 DEMLEAGVSGVFQPHGLGHLIGLDVHDVGGYLPteprrpseawlsKLRFARILKAGMYVTIEPGCYFIKQLMDKaladpq 434
Cdd:cd01087  155 DEIVESGAYAKFFPHGLGHYLGLDVHDVGGYLR------------YLRRARPLEPGMVITIEPGIYFIPDLLDV------ 216

                        250       260       270
                 ....*....|....*....|....*....|....
gi 195110797 435 irkyinvevfERFRNFGGVRIEDDVLITKTGTEN 468
Cdd:cd01087  217 ----------PEYFRGGGIRIEDDVLVTEDGPEN 240
AMP_N smart01011
Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the ...
 12-158 1.03e-35

Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the creatinase N-terminal domain. However, little or no sequence similarity exists between the two families.


:

Pssm-ID: 198079  Cd Length: 135  Bit Score: 129.28  E-value: 1.03e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195110797    12 VPMTLFKNNRNKVCKAILDNSqeslklssgqLIILLEGGKDQSlyNTDVDYVFRQESYFQYMFGAKEPGCYGIvsIDVKT 91
Cdd:smart01011   1 IPAAEYAARRRRLAAKLFPGS----------VAVLPAGPEKVR--SNDTDYPFRQDSDFYYLTGFDEPDAVLV--LDPSG 66

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 195110797    92 AQATSVLFVPRLPEEYETWMGALLKPEEFKAMYEVDEVYYVDELEAYLEKTTPK--LILTLSGTNSDSG 158
Cdd:smart01011  67 GGGKSTLFVPPRDPEDELWDGPRLGLEEAKEKFGVDEVYPIDELDAVLPGLLAGagTVYYLLGRDPDLD 135
 
Name Accession Description Interval E-value
Prolidase cd01087
Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline ...
 195-468 8.03e-120

Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.


Pssm-ID: 238520 [Multi-domain]  Cd Length: 243  Bit Score: 350.72  E-value: 8.03e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195110797 195 IEVLRYVAKVSSDAHIKVMQFIRPGRMEYEGESLFLHHAYAVGGCRHASYTCICGSgiNSAILHYGHagapNNRPIQDGE 274
Cdd:cd01087    1 IELMRKACDISAEAHRAAMKASRPGMSEYELEAEFEYEFRSRGARLAYSYIVAAGS--NAAILHYVH----NDQPLKDGD 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195110797 275 MCLFDMGANYCGYAADITCSFPANGKFTEDQKFIYNAVLAARNAVMETARDGVSWVNMHKLAGKVLLEQLKAGGMLTGDV 354
Cdd:cd01087   75 LVLIDAGAEYGGYASDITRTFPVNGKFTDEQRELYEAVLAAQKAAIAACKPGVSYEDIHLLAHRVLAEGLKELGILKGDV 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195110797 355 DEMLEAGVSGVFQPHGLGHLIGLDVHDVGGYLPteprrpseawlsKLRFARILKAGMYVTIEPGCYFIKQLMDKaladpq 434
Cdd:cd01087  155 DEIVESGAYAKFFPHGLGHYLGLDVHDVGGYLR------------YLRRARPLEPGMVITIEPGIYFIPDLLDV------ 216

                        250       260       270
                 ....*....|....*....|....*....|....
gi 195110797 435 irkyinvevfERFRNFGGVRIEDDVLITKTGTEN 468
Cdd:cd01087  217 ----------PEYFRGGGIRIEDDVLVTEDGPEN 240
PRK10879 PRK10879
proline aminopeptidase P II; Provisional
 57-484 2.39e-74

proline aminopeptidase P II; Provisional


Pssm-ID: 182804 [Multi-domain]  Cd Length: 438  Bit Score: 240.78  E-value: 2.39e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195110797  57 NTDVDYVFRQESYFQYMFGAKEPGCygiVSIDVKTAQAT--SVLFVPRLPEEYETWMGALLKPEEFKAMYEVDEVYYVDE 134
Cdd:PRK10879  34 SADSEYPYRQNSDFWYFTGFNEPEA---VLVLIKSDDTHnhSVLFNRVRDLTAEIWFGRRLGQDAAPEKLGVDRALPFSE 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195110797 135 LEAylekttpKLILTLSGTNSdsgLTMQPPEFAGKDKYVTNC-DLLY-----------------PIISECRVIKSKEEIE 196
Cdd:PRK10879 111 INQ-------QLYQLLNGLDV---VYHAQGEYAYADEIVFSAlEKLRkgsrqnltapatltdwrPWVHEMRLFKSPEEIA 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195110797 197 VLRYVAKVSSDAHIKVMQFIRPGRMEY--EGEslfLHHAYAVGGCRHASYTCICGSGINSAILHYghagAPNNRPIQDGE 274
Cdd:PRK10879 181 VLRRAGEISALAHTRAMEKCRPGMFEYqlEGE---IHHEFNRHGARYPSYNTIVGSGENGCILHY----TENESEMRDGD 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195110797 275 MCLFDMGANYCGYAADITCSFPANGKFTEDQKFIYNAVLAARNAVMETARDGVSWVNMHKLAGKVLLEQLKAGGMLTGDV 354
Cdd:PRK10879 254 LVLIDAGCEYKGYAGDITRTFPVNGKFTPAQREIYDIVLESLETSLRLYRPGTSIREVTGEVVRIMVSGLVKLGILKGDV 333

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195110797 355 DEMLEAGVSGVFQPHGLGHLIGLDVHDVGGYLPTEprrpseawlsklrfARILKAGMYVTIEPGCYFIKqlmdkaladpq 434
Cdd:PRK10879 334 DQLIAENAHRPFFMHGLSHWLGLDVHDVGVYGQDR--------------SRILEPGMVLTVEPGLYIAP----------- 388

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|.
gi 195110797 435 irkyiNVEVFERFRNFgGVRIEDDVLITKTGTENF-AIVPRTVEEIEATMA 484
Cdd:PRK10879 389 -----DADVPEQYRGI-GIRIEDDIVITETGNENLtASVVKKPDEIEALMA 433
PepP COG0006
Xaa-Pro aminopeptidase [Amino acid transport and metabolism];
179-479 1.01e-72

Xaa-Pro aminopeptidase [Amino acid transport and metabolism];


Pssm-ID: 439777 [Multi-domain]  Cd Length: 299  Bit Score: 232.02  E-value: 1.01e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195110797 179 LYPIISECRVIKSKEEIEVLRYVAKVSSDAHIKVMQFIRPGRMEYE--GEslfLHHAYAVGGCRHASYTCICGSGINSAI 256
Cdd:COG0006   63 ASDLLEELRAIKSPEEIELMRKAARIADAAHEAALAALRPGVTEREvaAE---LEAAMRRRGAEGPSFDTIVASGENAAI 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195110797 257 LHYGhagaPNNRPIQDGEMCLFDMGANYCGYAADITCSFPAnGKFTEDQKFIYNAVLAARNAVMETARDGVSWVNMHKLA 336
Cdd:COG0006  140 PHYT----PTDRPLKPGDLVLIDAGAEYDGYTSDITRTVAV-GEPSDEQREIYEAVLEAQEAAIAALKPGVTGGEVDAAA 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195110797 337 GKVLleqlkaggmltgdvdemLEAGVSGVFqPHGLGHLIGLDVHDVGGYLPTEPrrpseawlsklrfaRILKAGMYVTIE 416
Cdd:COG0006  215 RDVL-----------------AEAGYGEYF-PHGTGHGVGLDVHEGPQISPGND--------------RPLEPGMVFTIE 262

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 195110797 417 PGCYFIkqlmdkaladpqirkyinvevferfrNFGGVRIEDDVLITKTGTENFAIVPRTVEEI 479
Cdd:COG0006  263 PGIYIP--------------------------GIGGVRIEDTVLVTEDGAEVLTRLPRELLEL 299
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 196-463 1.40e-59

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 194.77  E-value: 1.40e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195110797  196 EVLRYVAKVSSDAHIKVMQFIRPGRMEYEGESLFLHHAYAVGGCRHASYTCICGSGINSAILHYghagAPNNRPIQDGEM 275
Cdd:pfam00557   1 ELMRKAARIAAAALEAALAAIRPGVTERELAAELEAARLRRGGARGPAFPPIVASGPNAAIPHY----IPNDRVLKPGDL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195110797  276 CLFDMGANYC-GYAADITCSFpANGKFTEDQKFIYNAVLAARNAVMETARDGVSWVNMHKLAGKVlleqLKAGGMltgdv 354
Cdd:pfam00557  77 VLIDVGAEYDgGYCSDITRTF-VVGKPSPEQRELYEAVLEAQEAAIAAVKPGVTGGDVDAAAREV----LEEAGL----- 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195110797  355 demleagvsGVFQPHGLGHLIGLDVHDvggylptEPRrpseawLSKLRFARILKAGMYVTIEPGCYFIKqlmdkaladpq 434
Cdd:pfam00557 147 ---------GEYFPHGLGHGIGLEVHE-------GPY------ISRGGDDRVLEPGMVFTIEPGIYFIP----------- 193

                         250       260
                  ....*....|....*....|....*....
gi 195110797  435 irkyinvevferfrNFGGVRIEDDVLITK 463
Cdd:pfam00557 194 --------------GWGGVRIEDTVLVTE 208
AMP_N smart01011
Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the ...
 12-158 1.03e-35

Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the creatinase N-terminal domain. However, little or no sequence similarity exists between the two families.


Pssm-ID: 198079  Cd Length: 135  Bit Score: 129.28  E-value: 1.03e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195110797    12 VPMTLFKNNRNKVCKAILDNSqeslklssgqLIILLEGGKDQSlyNTDVDYVFRQESYFQYMFGAKEPGCYGIvsIDVKT 91
Cdd:smart01011   1 IPAAEYAARRRRLAAKLFPGS----------VAVLPAGPEKVR--SNDTDYPFRQDSDFYYLTGFDEPDAVLV--LDPSG 66

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 195110797    92 AQATSVLFVPRLPEEYETWMGALLKPEEFKAMYEVDEVYYVDELEAYLEKTTPK--LILTLSGTNSDSG 158
Cdd:smart01011  67 GGGKSTLFVPPRDPEDELWDGPRLGLEEAKEKFGVDEVYPIDELDAVLPGLLAGagTVYYLLGRDPDLD 135
AMP_N pfam05195
Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the ...
 17-141 3.24e-35

Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the creatinase N-terminal domain (pfam01321). However, little or no sequence similarity exists between the two families.


Pssm-ID: 461581 [Multi-domain]  Cd Length: 121  Bit Score: 127.24  E-value: 3.24e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195110797   17 FKNNRNKVCKAILDNSqeslklssgqlIILLEGGKDQSLYNtDVDYVFRQESYFQYMFGAKEPGCYGIVsIDVKTAQATS 96
Cdd:pfam05195   1 YAERRARLLAKLPPNS-----------VAILPGAPEKYRNG-DVFYPFRQDSDFYYLTGFNEPDAVLVL-EGGDIDSGKE 67

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 195110797   97 VLFVPRLPEEYETWMGALLKPEEFKAMYEVDEVYYVDELEAYLEK 141
Cdd:pfam05195  68 TLFVPPKDPEDEIWDGPRLGPEEAKELFGVDEVYPIDELDEVLPK 112
 
Name Accession Description Interval E-value
Prolidase cd01087
Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline ...
 195-468 8.03e-120

Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.


Pssm-ID: 238520 [Multi-domain]  Cd Length: 243  Bit Score: 350.72  E-value: 8.03e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195110797 195 IEVLRYVAKVSSDAHIKVMQFIRPGRMEYEGESLFLHHAYAVGGCRHASYTCICGSgiNSAILHYGHagapNNRPIQDGE 274
Cdd:cd01087    1 IELMRKACDISAEAHRAAMKASRPGMSEYELEAEFEYEFRSRGARLAYSYIVAAGS--NAAILHYVH----NDQPLKDGD 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195110797 275 MCLFDMGANYCGYAADITCSFPANGKFTEDQKFIYNAVLAARNAVMETARDGVSWVNMHKLAGKVLLEQLKAGGMLTGDV 354
Cdd:cd01087   75 LVLIDAGAEYGGYASDITRTFPVNGKFTDEQRELYEAVLAAQKAAIAACKPGVSYEDIHLLAHRVLAEGLKELGILKGDV 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195110797 355 DEMLEAGVSGVFQPHGLGHLIGLDVHDVGGYLPteprrpseawlsKLRFARILKAGMYVTIEPGCYFIKQLMDKaladpq 434
Cdd:cd01087  155 DEIVESGAYAKFFPHGLGHYLGLDVHDVGGYLR------------YLRRARPLEPGMVITIEPGIYFIPDLLDV------ 216

                        250       260       270
                 ....*....|....*....|....*....|....
gi 195110797 435 irkyinvevfERFRNFGGVRIEDDVLITKTGTEN 468
Cdd:cd01087  217 ----------PEYFRGGGIRIEDDVLVTEDGPEN 240
PRK10879 PRK10879
proline aminopeptidase P II; Provisional
 57-484 2.39e-74

proline aminopeptidase P II; Provisional


Pssm-ID: 182804 [Multi-domain]  Cd Length: 438  Bit Score: 240.78  E-value: 2.39e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195110797  57 NTDVDYVFRQESYFQYMFGAKEPGCygiVSIDVKTAQAT--SVLFVPRLPEEYETWMGALLKPEEFKAMYEVDEVYYVDE 134
Cdd:PRK10879  34 SADSEYPYRQNSDFWYFTGFNEPEA---VLVLIKSDDTHnhSVLFNRVRDLTAEIWFGRRLGQDAAPEKLGVDRALPFSE 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195110797 135 LEAylekttpKLILTLSGTNSdsgLTMQPPEFAGKDKYVTNC-DLLY-----------------PIISECRVIKSKEEIE 196
Cdd:PRK10879 111 INQ-------QLYQLLNGLDV---VYHAQGEYAYADEIVFSAlEKLRkgsrqnltapatltdwrPWVHEMRLFKSPEEIA 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195110797 197 VLRYVAKVSSDAHIKVMQFIRPGRMEY--EGEslfLHHAYAVGGCRHASYTCICGSGINSAILHYghagAPNNRPIQDGE 274
Cdd:PRK10879 181 VLRRAGEISALAHTRAMEKCRPGMFEYqlEGE---IHHEFNRHGARYPSYNTIVGSGENGCILHY----TENESEMRDGD 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195110797 275 MCLFDMGANYCGYAADITCSFPANGKFTEDQKFIYNAVLAARNAVMETARDGVSWVNMHKLAGKVLLEQLKAGGMLTGDV 354
Cdd:PRK10879 254 LVLIDAGCEYKGYAGDITRTFPVNGKFTPAQREIYDIVLESLETSLRLYRPGTSIREVTGEVVRIMVSGLVKLGILKGDV 333

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195110797 355 DEMLEAGVSGVFQPHGLGHLIGLDVHDVGGYLPTEprrpseawlsklrfARILKAGMYVTIEPGCYFIKqlmdkaladpq 434
Cdd:PRK10879 334 DQLIAENAHRPFFMHGLSHWLGLDVHDVGVYGQDR--------------SRILEPGMVLTVEPGLYIAP----------- 388

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|.
gi 195110797 435 irkyiNVEVFERFRNFgGVRIEDDVLITKTGTENF-AIVPRTVEEIEATMA 484
Cdd:PRK10879 389 -----DADVPEQYRGI-GIRIEDDIVITETGNENLtASVVKKPDEIEALMA 433
PepP COG0006
Xaa-Pro aminopeptidase [Amino acid transport and metabolism];
179-479 1.01e-72

Xaa-Pro aminopeptidase [Amino acid transport and metabolism];


Pssm-ID: 439777 [Multi-domain]  Cd Length: 299  Bit Score: 232.02  E-value: 1.01e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195110797 179 LYPIISECRVIKSKEEIEVLRYVAKVSSDAHIKVMQFIRPGRMEYE--GEslfLHHAYAVGGCRHASYTCICGSGINSAI 256
Cdd:COG0006   63 ASDLLEELRAIKSPEEIELMRKAARIADAAHEAALAALRPGVTEREvaAE---LEAAMRRRGAEGPSFDTIVASGENAAI 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195110797 257 LHYGhagaPNNRPIQDGEMCLFDMGANYCGYAADITCSFPAnGKFTEDQKFIYNAVLAARNAVMETARDGVSWVNMHKLA 336
Cdd:COG0006  140 PHYT----PTDRPLKPGDLVLIDAGAEYDGYTSDITRTVAV-GEPSDEQREIYEAVLEAQEAAIAALKPGVTGGEVDAAA 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195110797 337 GKVLleqlkaggmltgdvdemLEAGVSGVFqPHGLGHLIGLDVHDVGGYLPTEPrrpseawlsklrfaRILKAGMYVTIE 416
Cdd:COG0006  215 RDVL-----------------AEAGYGEYF-PHGTGHGVGLDVHEGPQISPGND--------------RPLEPGMVFTIE 262

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 195110797 417 PGCYFIkqlmdkaladpqirkyinvevferfrNFGGVRIEDDVLITKTGTENFAIVPRTVEEI 479
Cdd:COG0006  263 PGIYIP--------------------------GIGGVRIEDTVLVTEDGAEVLTRLPRELLEL 299
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 196-463 1.40e-59

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 194.77  E-value: 1.40e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195110797  196 EVLRYVAKVSSDAHIKVMQFIRPGRMEYEGESLFLHHAYAVGGCRHASYTCICGSGINSAILHYghagAPNNRPIQDGEM 275
Cdd:pfam00557   1 ELMRKAARIAAAALEAALAAIRPGVTERELAAELEAARLRRGGARGPAFPPIVASGPNAAIPHY----IPNDRVLKPGDL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195110797  276 CLFDMGANYC-GYAADITCSFpANGKFTEDQKFIYNAVLAARNAVMETARDGVSWVNMHKLAGKVlleqLKAGGMltgdv 354
Cdd:pfam00557  77 VLIDVGAEYDgGYCSDITRTF-VVGKPSPEQRELYEAVLEAQEAAIAAVKPGVTGGDVDAAAREV----LEEAGL----- 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195110797  355 demleagvsGVFQPHGLGHLIGLDVHDvggylptEPRrpseawLSKLRFARILKAGMYVTIEPGCYFIKqlmdkaladpq 434
Cdd:pfam00557 147 ---------GEYFPHGLGHGIGLEVHE-------GPY------ISRGGDDRVLEPGMVFTIEPGIYFIP----------- 193

                         250       260
                  ....*....|....*....|....*....
gi 195110797  435 irkyinvevferfrNFGGVRIEDDVLITK 463
Cdd:pfam00557 194 --------------GWGGVRIEDTVLVTE 208
PRK13607 PRK13607
proline dipeptidase; Provisional
 187-468 1.25e-57

proline dipeptidase; Provisional


Pssm-ID: 237444 [Multi-domain]  Cd Length: 443  Bit Score: 197.04  E-value: 1.25e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195110797 187 RVIKSKEEIEVLRYVAKVSSDAHIKVMQFIRPGRMEYEgeslfLHHAY--AVG-GCRHASYTCICGSGINSAILHYGHag 263
Cdd:PRK13607 159 RAYKTDYELACMREAQKIAVAGHRAAKEAFRAGMSEFD-----INLAYltATGqRDNDVPYGNIVALNEHAAVLHYTK-- 231

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195110797 264 aPNNRPIQDGEMCLFDMGANYCGYAADITCSFPANGK--FTEdqkfIYNAVLAARNAVMETARDGVSWVNMHKLAGKVLL 341
Cdd:PRK13607 232 -LDHQAPAEMRSFLIDAGAEYNGYAADITRTYAAKEDndFAA----LIKDVNKEQLALIATMKPGVSYVDLHIQMHQRIA 306

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195110797 342 EQLKAGGMLTG-DVDEMLEAGVSGVFQPHGLGHLIGLDVHDVGGYLPTE---PRRPSEAWLSkLRFARILKAGMYVTIEP 417
Cdd:PRK13607 307 KLLRKFQIVTGlSEEAMVEQGITSPFFPHGLGHPLGLQVHDVAGFMQDDrgtHLAAPEKHPY-LRCTRVLEPGMVLTIEP 385

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 195110797 418 GCYFIKQLMDKALADPQiRKYINVEVFERFRNFGGVRIEDDVLITKTGTEN 468
Cdd:PRK13607 386 GLYFIDSLLAPLREGPF-SKHFNWQKIDALKPFGGIRIEDNVVVHENGVEN 435
APP-like cd01092
Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse ...
 195-465 1.17e-37

Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline.


Pssm-ID: 238525 [Multi-domain]  Cd Length: 208  Bit Score: 136.87  E-value: 1.17e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195110797 195 IEVLRYVAKVSSDAHIKVMQFIRPGRMEYEgESLFLHHAYAVGGCRHASYTCICGSGINSAILHyGHAGapnNRPIQDGE 274
Cdd:cd01092    1 IELLRKAARIADKAFEELLEFIKPGMTERE-VAAELEYFMRKLGAEGPSFDTIVASGPNSALPH-GVPS---DRKIEEGD 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195110797 275 MCLFDMGANYCGYAADITCSFpANGKFTEDQKFIYNAVLAARNAVMETARDGVSWVNMHKLAGKVLLEqlkaggmltgdv 354
Cdd:cd01092   76 LVLIDFGAIYDGYCSDITRTV-AVGEPSDELKEIYEIVLEAQQAAIKAVKPGVTAKEVDKAARDVIEE------------ 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195110797 355 demleAGVSGVFqPHGLGHLIGLDVHDvggylptEPRrpseawLSKlRFARILKAGMYVTIEPGCYFikqlmdkaladPq 434
Cdd:cd01092  143 -----AGYGEYF-IHRTGHGVGLEVHE-------APY------ISP-GSDDVLEEGMVFTIEPGIYI-----------P- 190

                        250       260       270
                 ....*....|....*....|....*....|.
gi 195110797 435 irkyinvevferfrNFGGVRIEDDVLITKTG 465
Cdd:cd01092  191 --------------GKGGVRIEDDVLVTEDG 207
APP_MetAP cd01066
A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as ...
 195-466 6.03e-36

A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity compared to other metallo-aminopeptidases, suggesting they play roles in regulation of biological processes rather than general protein degradation.


Pssm-ID: 238514 [Multi-domain]  Cd Length: 207  Bit Score: 132.19  E-value: 6.03e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195110797 195 IEVLRYVAKVSSDAHIKVMQFIRPGRMEYEGESLFlhHAYAVGGCRHASYTCICGSGINSAILHYGhagaPNNRPIQDGE 274
Cdd:cd01066    1 IARLRKAAEIAEAAMAAAAEAIRPGVTEAEVAAAI--EQALRAAGGYPAGPTIVGSGARTALPHYR----PDDRRLQEGD 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195110797 275 MCLFDMGANYCGYAADITCSFPaNGKFTEDQKFIYNAVLAARNAVMETARDGVSWVNMHKLAGKVlleqlkaggmltgdv 354
Cdd:cd01066   75 LVLVDLGGVYDGYHADLTRTFV-IGEPSDEQRELYEAVREAQEAALAALRPGVTAEEVDAAAREV--------------- 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195110797 355 deMLEAGVSGVFqPHGLGHLIGLDVHdvggylpteprrpsEAWLSKLRFARILKAGMYVTIEPGCYFIKQlmdkaladpq 434
Cdd:cd01066  139 --LEEHGLGPNF-GHRTGHGIGLEIH--------------EPPVLKAGDDTVLEPGMVFAVEPGLYLPGG---------- 191

                        250       260       270
                 ....*....|....*....|....*....|..
gi 195110797 435 irkyinvevferfrnfGGVRIEDDVLITKTGT 466
Cdd:cd01066  192 ----------------GGVRIEDTVLVTEDGP 207
AMP_N smart01011
Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the ...
 12-158 1.03e-35

Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the creatinase N-terminal domain. However, little or no sequence similarity exists between the two families.


Pssm-ID: 198079  Cd Length: 135  Bit Score: 129.28  E-value: 1.03e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195110797    12 VPMTLFKNNRNKVCKAILDNSqeslklssgqLIILLEGGKDQSlyNTDVDYVFRQESYFQYMFGAKEPGCYGIvsIDVKT 91
Cdd:smart01011   1 IPAAEYAARRRRLAAKLFPGS----------VAVLPAGPEKVR--SNDTDYPFRQDSDFYYLTGFDEPDAVLV--LDPSG 66

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 195110797    92 AQATSVLFVPRLPEEYETWMGALLKPEEFKAMYEVDEVYYVDELEAYLEKTTPK--LILTLSGTNSDSG 158
Cdd:smart01011  67 GGGKSTLFVPPRDPEDELWDGPRLGLEEAKEKFGVDEVYPIDELDAVLPGLLAGagTVYYLLGRDPDLD 135
AMP_N pfam05195
Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the ...
 17-141 3.24e-35

Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the creatinase N-terminal domain (pfam01321). However, little or no sequence similarity exists between the two families.


Pssm-ID: 461581 [Multi-domain]  Cd Length: 121  Bit Score: 127.24  E-value: 3.24e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195110797   17 FKNNRNKVCKAILDNSqeslklssgqlIILLEGGKDQSLYNtDVDYVFRQESYFQYMFGAKEPGCYGIVsIDVKTAQATS 96
Cdd:pfam05195   1 YAERRARLLAKLPPNS-----------VAILPGAPEKYRNG-DVFYPFRQDSDFYYLTGFNEPDAVLVL-EGGDIDSGKE 67

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 195110797   97 VLFVPRLPEEYETWMGALLKPEEFKAMYEVDEVYYVDELEAYLEK 141
Cdd:pfam05195  68 TLFVPPKDPEDEIWDGPRLGPEEAKELFGVDEVYPIDELDEVLPK 112
PRK09795 PRK09795
aminopeptidase; Provisional
 183-476 7.25e-25

aminopeptidase; Provisional


Pssm-ID: 182080 [Multi-domain]  Cd Length: 361  Bit Score: 105.40  E-value: 7.25e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195110797 183 ISECRVIKSKEEIEVLRYVAKV--SSDAHIKvmQFIRPGRMEYEGES---LFLHHAyavgGCRHASYTCICGSGINSAIL 257
Cdd:PRK09795 121 PDVLRQIKTPEEVEKIRLACGIadRGAEHIR--RFIQAGMSEREIAAeleWFMRQQ----GAEKASFDTIVASGWRGALP 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195110797 258 HyghaGAPNNRPIQDGEMCLFDMGANYCGYAADITCSFPANGKFTEDQKF----IYNAVLAARNAVMETARDGVSWVNMH 333
Cdd:PRK09795 195 H----GKASDKIVAAGEFVTLDFGALYQGYCSDMTRTLLVNGEGVSAESHplfnVYQIVLQAQLAAISAIRPGVRCQQVD 270

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195110797 334 KLAGKVLLEqlkaggmltgdvdemleAGVSGVFQpHGLGHLIGLDVHDVGGYLPTEPRRpseawlsklrfariLKAGMYV 413
Cdd:PRK09795 271 DAARRVITE-----------------AGYGDYFG-HNTGHAIGIEVHEDPRFSPRDTTT--------------LQPGMLL 318

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 195110797 414 TIEPGCYFIKQlmdkaladpqirkyinvevferfrnfGGVRIEDDVLITKTGTENFAIVPRTV 476
Cdd:PRK09795 319 TVEPGIYLPGQ--------------------------GGVRIEDVVLVTPQGAEVLYAMPKTV 355
APP cd01085
X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline ...
 243-469 4.60e-16

X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, even from a dipeptide or tripeptide.


Pssm-ID: 238518 [Multi-domain]  Cd Length: 224  Bit Score: 77.22  E-value: 4.60e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195110797 243 SYTCICGSGINSAILHYgHAGAPNNRPIQDGEMCLFDMGANYCGYAADITCSFpANGKFTEDQKFIYNAVLAARNAVMeT 322
Cdd:cd01085   53 SFDTISGFGPNGAIVHY-SPTEESNRKISPDGLYLIDSGGQYLDGTTDITRTV-HLGEPTAEQKRDYTLVLKGHIALA-R 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195110797 323 AR--DGVSWVNMHKLAGKVLLeqlkaggmltgdvDEMLEAGvsgvfqpHGLGHLIG--LDVHDvggyLPTEPRRPSEAWl 398
Cdd:cd01085  130 AKfpKGTTGSQLDALARQPLW-------------KAGLDYG-------HGTGHGVGsfLNVHE----GPQSISPAPNNV- 184

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 195110797 399 sklrfarILKAGMYVTIEPGCYfikqlmdkaLADpqirKYinvevferfrnfgGVRIEDDVLITKTGTENF 469
Cdd:cd01085  185 -------PLKAGMILSNEPGYY---------KEG----KY-------------GIRIENLVLVVEAETTEF 222
Map COG0024
Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];
189-427 2.96e-09

Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 439795 [Multi-domain]  Cd Length: 250  Bit Score: 57.71  E-value: 2.96e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195110797 189 IKSKEEIEVLRYVAKVSSDAHIKVMQFIRPGR-------------MEYEGESLFLHhayaVGGCRHAsyTCICgsgINSA 255
Cdd:COG0024    3 IKTPEEIEKMREAGRIVAEVLDELAEAVKPGVttleldriaeefiRDHGAIPAFLG----YYGFPKS--ICTS---VNEV 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195110797 256 ILHyghaGAPNNRPIQDGEMCLFDMGANYCGYAADITCSFPAnGKFT-EDQKFIYnavlAARNAVMetardgvswvnmhk 334
Cdd:COG0024   74 VVH----GIPSDRVLKDGDIVNIDVGAILDGYHGDSARTFVV-GEVSpEARRLVE----VTEEALY-------------- 130

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195110797 335 lAGkvlLEQLKAGGMLtGDVDEMLEAgvsgVFQPHGL-------GHLIGLDVHDvggylptEP-----RRPSEawlsklr 402
Cdd:COG0024  131 -AG---IAAAKPGNRL-GDIGHAIQS----YAESNGYsvvrefvGHGIGREMHE-------EPqvpnyGRPGR------- 187

                        250       260
                 ....*....|....*....|....*....
gi 195110797 403 fARILKAGMYVTIEP----GCYFIKQLMD 427
Cdd:COG0024  188 -GPRLKPGMVLAIEPminaGTPEVKVLDD 215
PRK12896 PRK12896
methionine aminopeptidase; Reviewed
 188-467 2.21e-06

methionine aminopeptidase; Reviewed


Pssm-ID: 237252 [Multi-domain]  Cd Length: 255  Bit Score: 49.06  E-value: 2.21e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195110797 188 VIKSKEEIEVLRYVAKVSSDAHIKVMQFIRPG------------RMEYEGeslflhhAY-AVGGCRH--ASyTCICgsgI 252
Cdd:PRK12896   9 EIKSPRELEKMRKIGRIVATALKEMGKAVEPGmttkeldriaekRLEEHG-------AIpSPEGYYGfpGS-TCIS---V 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195110797 253 NSAILHyghaGAPNNRPIQDGEMCLFDMGANYCGYAADiTC-SFPAnGKFTEDqkfIYNAVLAARNAVMetardgvswvn 331
Cdd:PRK12896  78 NEEVAH----GIPGPRVIKDGDLVNIDVSAYLDGYHGD-TGiTFAV-GPVSEE---AEKLCRVAEEALW----------- 137

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195110797 332 mhklAGkvlLEQLKAGGMLtgdvdemleAGVSGVFQPHG-----------LGHLIGLDVHDVGGYLPTEPrRPSEawlsk 400
Cdd:PRK12896 138 ----AG---IKQVKAGRPL---------NDIGRAIEDFAkkngysvvrdlTGHGVGRSLHEEPSVILTYT-DPLP----- 195

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 195110797 401 lrfARILKAGMYVTIEP----GCYFIKQL--------MDKALAdpqirkyinvevferfrnfggVRIEDDVLITKTGTE 467
Cdd:PRK12896 196 ---NRLLRPGMTLAVEPflnlGAKDAETLddgwtvvtPDKSLS---------------------AQFEHTVVVTRDGPE 250
PRK15173 PRK15173
peptidase; Provisional
 170-474 1.24e-03

peptidase; Provisional


Pssm-ID: 185095 [Multi-domain]  Cd Length: 323  Bit Score: 40.86  E-value: 1.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195110797 170 DKYVTNCDLL--YPIISECRVIKSKEEIEVLRYVAKVSSDAHIKVMQFIRPGRMEYEGESLFLHHAYAVGGCRHASYTCI 247
Cdd:PRK15173  74 DAVMPNVDFVdsSSIFNELRVIKSPWEIKRLRKSAEITEYGITEASKLIRVGCTSAELTAAYKAAVMSKSETHFSRFHLI 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195110797 248 -CGSGINSAILhyghagaPNNRPIQDGEMCLFDMGANYCGYAADITCSFPAnGKFTEDQKFIYNAVLAARNAVMETARDG 326
Cdd:PRK15173 154 sVGADFSPKLI-------PSNTKACSGDLIKFDCGVDVDGYGADIARTFVV-GEPPEITRKIYQTIRTGHEHMLSMVAPG 225

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195110797 327 VSWVNMHKLAgkvlLEQLKAGGMLTGDVDEMleagvsgvfqPHGLGHLIGLDVHdvggylPTEPRRPSEAWLSklrfari 406
Cdd:PRK15173 226 VKMKDVFDST----MEVIKKSGLPNYNRGHL----------GHGNGVFLGLEES------PFVSTHATESFTS------- 278

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 195110797 407 lkaGMYVTIEPGCYFIkqlmdkaladpqirkyinvevferfrNFGGVRIEDDVLITKTGTENFAIVPR 474
Cdd:PRK15173 279 ---GMVLSLETPYYGY--------------------------NLGSIMIEDMILINKEGIEFLSKLPR 317
PRK14575 PRK14575
putative peptidase; Provisional
 170-474 2.06e-03

putative peptidase; Provisional


Pssm-ID: 173039 [Multi-domain]  Cd Length: 406  Bit Score: 40.46  E-value: 2.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195110797 170 DKYVTNCDLL--YPIISECRVIKSKEEIEVLRYVAKVSSDAHIKVMQFIRPGRMEYEGESLFLHHAYAVGGCRHASYTCI 247
Cdd:PRK14575 157 DAVMPNVDFVdsSSIFNELRVIKSPWEIKRLRKSAEITEYGITEASKLIRVGCTSAELTAAYKAAVMSKSETHFSRFHLI 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195110797 248 -CGSGINSAILhyghagaPNNRPIQDGEMCLFDMGANYCGYAADITCSFPAnGKFTEDQKFIYNAVLAARNAVMETARDG 326
Cdd:PRK14575 237 sVGADFSPKLI-------PSNTKACSGDLIKFDCGVDVDGYGADIARTFVV-GEPPEITRKIYQTIRTGHEHMLSMVAPG 308

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195110797 327 VSWVNMHKLAgkvlLEQLKAGGMLTGDVDEMleagvsgvfqPHGLGHLIGLDVHdvggylPTEPRRPSEAWLSklrfari 406
Cdd:PRK14575 309 VKMKDVFDST----MEVIKKSGLPNYNRGHL----------GHGNGVFLGLEES------PFVSTHATESFTS------- 361

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 195110797 407 lkaGMYVTIEPGCYFIkqlmdkaladpqirkyinvevferfrNFGGVRIEDDVLITKTGTENFAIVPR 474
Cdd:PRK14575 362 ---GMVLSLETPYYGY--------------------------NLGSIMIEDMILINKEGIEFLSKLPR 400
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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