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Conserved domains on  [gi|290981428|ref|XP_002673432|]
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uncharacterized protein NAEGRDRAFT_71314 [Naegleria gruberi]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BBE super family cl06869
Berberine and berberine like; This domain is found in the berberine bridge and berberine ...
 264-307 6.86e-10

Berberine and berberine like; This domain is found in the berberine bridge and berberine bridge- like enzymes which are involved in the biosynthesis of numerous isoquinoline alkaloids. They catalyze the transformation of the N-methyl group of (S)-reticuline into the C-8 berberine bridge carbon of (S)-scoulerine.


The actual alignment was detected with superfamily member pfam08031:

Pssm-ID: 369658 [Multi-domain]  Cd Length: 45  Bit Score: 53.72  E-value: 6.86e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 290981428  264 SYVNYCDAYLKDYEFAYYSINMFKLRELKKKYDPFNLFKYEQSI 307
Cdd:pfam08031   1 AYVNYPDLDLGDWGERYFGSNFERLVEVKAKYDPDNVFRNEQSI 44
GlcD super family cl43085
FAD/FMN-containing lactate dehydrogenase/glycolate oxidase [Energy production and conversion];
2-51 7.23e-04

FAD/FMN-containing lactate dehydrogenase/glycolate oxidase [Energy production and conversion];


The actual alignment was detected with superfamily member COG0277:

Pssm-ID: 440046 [Multi-domain]  Cd Length: 462  Bit Score: 41.03  E-value: 7.23e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 290981428   2 EIINHDSKLLKiNQTNEfnDLFWAMKGGGnGNFGVIVSLSFKLIKAPKMV 51
Cdd:COG0277  174 EVVRTGGRVPK-NVTGY--DLFWLLVGSE-GTLGVITEATLRLHPLPEAV 219
 
Name Accession Description Interval E-value
BBE pfam08031
Berberine and berberine like; This domain is found in the berberine bridge and berberine ...
 264-307 6.86e-10

Berberine and berberine like; This domain is found in the berberine bridge and berberine bridge- like enzymes which are involved in the biosynthesis of numerous isoquinoline alkaloids. They catalyze the transformation of the N-methyl group of (S)-reticuline into the C-8 berberine bridge carbon of (S)-scoulerine.


Pssm-ID: 369658 [Multi-domain]  Cd Length: 45  Bit Score: 53.72  E-value: 6.86e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 290981428  264 SYVNYCDAYLKDYEFAYYSINMFKLRELKKKYDPFNLFKYEQSI 307
Cdd:pfam08031   1 AYVNYPDLDLGDWGERYFGSNFERLVEVKAKYDPDNVFRNEQSI 44
GlcD COG0277
FAD/FMN-containing lactate dehydrogenase/glycolate oxidase [Energy production and conversion];
2-51 7.23e-04

FAD/FMN-containing lactate dehydrogenase/glycolate oxidase [Energy production and conversion];


Pssm-ID: 440046 [Multi-domain]  Cd Length: 462  Bit Score: 41.03  E-value: 7.23e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 290981428   2 EIINHDSKLLKiNQTNEfnDLFWAMKGGGnGNFGVIVSLSFKLIKAPKMV 51
Cdd:COG0277  174 EVVRTGGRVPK-NVTGY--DLFWLLVGSE-GTLGVITEATLRLHPLPEAV 219
 
Name Accession Description Interval E-value
BBE pfam08031
Berberine and berberine like; This domain is found in the berberine bridge and berberine ...
 264-307 6.86e-10

Berberine and berberine like; This domain is found in the berberine bridge and berberine bridge- like enzymes which are involved in the biosynthesis of numerous isoquinoline alkaloids. They catalyze the transformation of the N-methyl group of (S)-reticuline into the C-8 berberine bridge carbon of (S)-scoulerine.


Pssm-ID: 369658 [Multi-domain]  Cd Length: 45  Bit Score: 53.72  E-value: 6.86e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 290981428  264 SYVNYCDAYLKDYEFAYYSINMFKLRELKKKYDPFNLFKYEQSI 307
Cdd:pfam08031   1 AYVNYPDLDLGDWGERYFGSNFERLVEVKAKYDPDNVFRNEQSI 44
GlcD COG0277
FAD/FMN-containing lactate dehydrogenase/glycolate oxidase [Energy production and conversion];
2-51 7.23e-04

FAD/FMN-containing lactate dehydrogenase/glycolate oxidase [Energy production and conversion];


Pssm-ID: 440046 [Multi-domain]  Cd Length: 462  Bit Score: 41.03  E-value: 7.23e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 290981428   2 EIINHDSKLLKiNQTNEfnDLFWAMKGGGnGNFGVIVSLSFKLIKAPKMV 51
Cdd:COG0277  174 EVVRTGGRVPK-NVTGY--DLFWLLVGSE-GTLGVITEATLRLHPLPEAV 219
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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