BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383866442  32 LVDVTLVCEGQKLRVHKLVLASNSTYFEEILQK-DLSQEPIIFLKDLNFEILKAMVEFMYCGETTVPYQLLSSLLTATKT 110
Cdd:cd18315    1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKEtPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                 ....*
gi 383866442 111 FKVKE 115
Cdd:cd18315   81 LQIKG 85

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383866442  32 LVDVTLVCEGQKLRVHKLVLASNSTYFEEILQK-DLSQEPIIFLKDLNFEILKAMVEFMYCGETTVPYQLLSSLLTATKT 110
Cdd:cd18315    1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKEtPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                 ....*
gi 383866442 111 FKVKE 115
Cdd:cd18315   81 LQIKG 85

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383866442    34 DVTLVCEGQKLRVHKLVLASNSTYFEEILQKDL--SQEPIIFLKDLNFEILKAMVEFMYCGETTVPYQLLSSLLTATKTF 111
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFkeSDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|...
gi 383866442   112 KVKELTSVVDAMM 124
Cdd:smart00225  81 QIPGLVELCEEFL 93

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383866442  32 LVDVTLVCEGQKLRVHKLVLASNSTYFEEILQK-DLSQEPIIFLKDLNFEILKAMVEFMYCGETTVPYQLLSSLLTATKT 110
Cdd:cd18315    1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKEtPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                 ....*
gi 383866442 111 FKVKE 115
Cdd:cd18315   81 LQIKG 85

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383866442   23 FSELLARQALVDVTLVCEGQKLRVHKLVLASNSTYFEEILQKDLSQEPI--IFLKDLNFEILKAMVEFMYCGETTVPYQL 100
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVseITLDDVSPEDFEALLEFMYTGKLISEENV 80

                          90
                  ....*....|....*..
gi 383866442  101 LSSLLTATKtFKVKELT 117
Cdd:pfam00651  81 DDLLAAADK-LQIPSLV 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383866442  28 ARQaLVDVTLVCEGQKLRVHKLVLASNSTYFEEILQKDLSQEPIIF--LKDLNFEILKAMVEFMYCGETTVPYQLLSSLL 105
Cdd:cd18306   15 NRQ-FCDVILQVGGHEIPAHRAVLACASPYLFELFSSDSDGESILTvkLDGLDPDAVEVLVNYAYTSRLEVPADLVKSVY 93

                         90
                 ....*....|....
gi 383866442 106 TATKTFKVKELTSV 119
Cdd:cd18306   94 SAAKKLKMDRVKKA 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383866442  25 ELLARQALVDVTLVCEGQKLRVHKLVLASNSTYFEEILQKDL--SQEPIIFLKDLNFEILKAMVEFMYCGETTVPYQLLS 102
Cdd:cd18238    8 QFYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEMaeSKQDSITIKDIDEEAVELLVDFAYTGKLTLTVDNVQ 87

                         90
                 ....*....|....*..
gi 383866442 103 SLLTATKTFKVKELTSV 119
Cdd:cd18238   88 SLLYAASLLQVEEVAKA 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383866442  15 HARFITEKFSELLARQALVDVTLVCEGQKLRVHKLVLASNSTYFEEILQKDL--SQEPIIFLKDLNFEILKAMVEFMYCG 92
Cdd:cd18287    5 HVHFLSEDIGALFLNEEYSDVTFVVEEKRFPAHRVILAARSEYFRALLYGGMreSQQSEIELKDTNAEAFKALLKYIYTG 84

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383866442  15 HARFITEKFSELLARQALVDVTLVCEGQKLRVHKLVLASNSTYFEEILQKDLSQ--EPIIFLKDLNFEILKAMVEFMYCG 92
Cdd:cd18256    3 HASLILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAGGMSEssKDVVQIHGVEPDIFHILLDFIYTG 82

                         90       100       110
                 ....*....|....*....|....*....|
gi 383866442  93 ETTVPYQLLSSLLTATKTFkvkELTSVVDA 122
Cdd:cd18256   83 VVEVTVSNVQELLVAADML---QLTEVVEI 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383866442  14 GHARFITEKFSELLARQALVDVTLVCEGQKLRVHKLVLASNSTYFEEILQKDLS---QEPIIfLKDLNFEILKAMVEFMY 90
Cdd:cd18235    3 QHTQKAFDVMNELRKQNLLCDVILVADGVEIPAHRVVLASCSPYFHAMFTGDLSesrANRVT-LQDVDGKALLLLIDYVY 81

                         90       100       110
                 ....*....|....*....|....*....|..
gi 383866442  91 CGETTVPYQLLSSLLTATKTFkvkELTSVVDA 122
Cdd:cd18235   82 TAEIQVTEENVQVLLPAANLL---QLTDVRDA 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383866442  32 LVDVTLVCEGQKLRVHKLVLASNSTYFEEILQKDLS--QEPIIFLKDLNFEILKAMVEFMYCG---ETTVPYQLLSSLLT 106
Cdd:cd18297   12 MSDVTFLVEGRPFYAHKIVLVTASDRFKSMLSSGSTeaQTPVIEIPDIRYDIFQLMMQYLYTGgveSLDVAQDDALELLR 91

                         90
                 ....*....|
gi 383866442 107 ATKTFKVKEL 116
Cdd:cd18297   92 AASFFQLDGL 101

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383866442  21 EKFSELLARQALVDVTLVC-EGQKLRVHKLVLASNSTYFEEILqkdLSQEPIIFLKDLNFEILKAMVEFMYCGETTVPYQ 99
Cdd:cd18299    1 EDLRNLLHSPSCADVVFILqGGVRIFAHRIVLAAASSVFADLF---LMMTVVTLDSDITPEAFRRVLEFLYTGVLDENED 77

                         90       100
                 ....*....|....*....|.
gi 383866442 100 LLSSLLTATKTFKVKELTSVV 120
Cdd:cd18299   78 DLKELKDAAELLELFDLVMMC 98

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383866442  10 LQWAGHARFITEKFSELLARQALVDVTLVCEGQKLRVHKLVLASNSTYFEEIL--QKDLSQEpIIFLKDLNFEILKAMVE 87
Cdd:cd18212    1 IHSKTHKDTVLTNFEEQRKKDFLCDITLIVENVQFRAHKALLAASSEYFSMMFadEGEVGQS-IYMLEGMVAETFGALLE 79

                         90       100
                 ....*....|....*....|....*....
gi 383866442  88 FMYCGETTVPYQLLSSLLTATKTFKVKEL 116
Cdd:cd18212   80 FIYTGCLQVGEKSLEQILATAQFLKVNDL 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383866442  15 HARFITEKFSELLARQALVDVTLVCEGQKLRVHKLVLASNSTYFEEILQKDLSQEPI--IFLKDLNFEILKAMVEFMYCG 92
Cdd:cd18339    4 HMKKAFKVMNELRSKQLLCDVTIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAkkIEIKDVDGQTLSKLIDYIYTA 83

                         90       100
                 ....*....|....*....|....
gi 383866442  93 ETTVPYQLLSSLLTATKTFKVKEL 116
Cdd:cd18339   84 EIEVTEENVQVLLPAASLLQLMDV 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383866442  25 ELLARQALVDVTLVCEGQKLRVHKLVLASNSTYFEEILQKDL--SQEPIIFLKDLNFEILKAMVEFMYCGETTVPYQLLS 102
Cdd:cd18237   14 NMRKQKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNMteSKSSEVELKDAEPDIIELLVEFAYTARISVNSNNVQ 93

                         90
                 ....*....|.
gi 383866442 103 SLLTATKTFKV 113
Cdd:cd18237   94 SLLDAANQYQI 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383866442  15 HARFITEKFSELLARQALVDVTLVCEGQKLRVHKLVLASNSTYFEEILQKDL--SQEPIIFLKDLNFEILKAMVEFMYCG 92
Cdd:cd18215    2 HASDVLLNLNRLRSRDILTDVVLVVGREQFRAHKTVLMACSGLFYSIFTDQLknNVSVINLDPEIEPEGFRILLDFMYTS 81

                         90       100       110
                 ....*....|....*....|....*....|
gi 383866442  93 ETTVPYQLLSSLLtATKTFKVKELtsVVDA 122
Cdd:cd18215   82 RLNLREGNIMAVM-ATAMYLQMEH--VVDT 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383866442  32 LVDVTLVCEGQKLRVHKLVLASNSTYFEEILQKDL--SQEPIIFLKDLNFEILKAMVEFMYCGETTVPYQLLSSLLtATK 109
Cdd:cd18234    1 LCDVILIAGDRRIPAHRLVLSAVSDYFAAMFTNDVreATEEEIKLKDVDPDALWTLVQYCYTGRLELKEDNVESLL-ATA 79

                         90
                 ....*....|...
gi 383866442 110 TFkvKELTSVVDA 122
Cdd:cd18234   80 CL--LQLSEVVEA 90

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383866442  34 DVTLVCEGQKLRVHKLVLASNSTYFEEILQKDLSQEPI--IFLKDLNFEILKAMVEFMYCGETTVPYQLLSSLLTATKTF 111
Cdd:cd18314    8 DVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIESNLkeVTLEDVEPEIFETVLKYMYTGQVTLSEENVLDLLMLASKY 87

                 ....*
gi 383866442 112 KVKEL 116
Cdd:cd18314   88 QVPDL 92

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383866442  19 ITEKFSELLARQALVDVTLVCEGQKLRVHKLVLASNSTYFEEILQKDLSQEPIIFLKDLN-----FEILKAMVEFMYCGE 93
Cdd:cd18292    4 FLQDIAQLYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSNDWWSESKQSEIELVedpecAAVFEKFLRYLYTGQ 83

                         90
                 ....*....|....*..
gi 383866442  94 TTV-PYQLLSSLLTATK 109
Cdd:cd18292   84 ISVnLETALPLLMLADK 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383866442  19 ITEKFSELLARQALVDVTLVCEGQKLRVHKLVLASNSTYFEEILQKDL--SQEPIIFLKDLNFEILKAMVEFMYCGETTV 96
Cdd:cd18343    8 LAEDLGNLWENSRFTDCSLFVGGQEFKAHKSILAARSPVFNAMFEHEMeeSKKNRVEINDVDPEVFKEMMRFIYTGKAPN 87

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 383866442  97 PYQLLSSLLTATKTFKVKELTSVVDAMMTSG--IEN 130
Cdd:cd18343   88 LDKMADNLLAAADKYALERLKVMCEEALCNNlsVEN 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383866442   1 MVESTDICVLQWAGHARFITEKFSELLARQALVDVTLVCEGQKLRVHKLVLASNSTYFEEILQKDLsQEPI---IFLKDL 77
Cdd:cd18259    1 MVRNIDDLDFCLPSHPQSILDGLQTLRSNPKLSDVTLLVGGREFPCHRSVLALCSHYFNAMFTGDF-VESIsarVEIKDV 79

                         90
                 ....*....|....*....
gi 383866442  78 NFEILKAMVEFMYCGETTV 96
Cdd:cd18259   80 DPAVMESLIDFAYTGKLTI 98

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383866442  34 DVTLVCEGQKLRVHKLVLASNSTYFEEILQKDLS---QEPIIFLKDLNFEILKAMVEFMYCGETTVPYQLLSSLLTATKT 110
Cdd:cd18293   17 DVLLQAEGESVPAHCCVLSACSPYLTERLSSEPPpagQKVVLELQGLKAHTLLKLVDFLYTSELEVSSEEAQDVLAAARR 96

                 ....*...
gi 383866442 111 FKVKELTS 118
Cdd:cd18293   97 LQISELES 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383866442  15 HARFITEKFSELLARQALVDVTLVCEGQKLRVHKLVLASNSTYFEEILQKDLSQ--EPIIFLKDLNFEILKAMVEFMYCG 92
Cdd:cd18244   13 HDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRErdQDKIHLKGLTATGFSHVLQFMYYG 92

                         90       100
                 ....*....|....*....|....
gi 383866442  93 ETTVPYQLLSSLLTATKTFKVKEL 116
Cdd:cd18244   93 TIELSMLTVHEILQAAMYVQLTEV 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383866442  32 LVDVTLVCEGQKLRVHKLVLASNSTYFEEILQKDL--SQEPIIFLKDLNFEILKAMVEFMYCGETTVPYQLLSSLLTATK 109
Cdd:cd18326   25 LCDVVILVEGREFPTHRSVLAACSQYFKKLFTSGAvvDQQNVYEIDFVSAEALTALLDFAYTATLTVSTSNVGDILSAAR 104

                         90
                 ....*....|
gi 383866442 110 TFKVKELTSV 119
Cdd:cd18326  105 LLEIPAVSHV 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383866442  24 SELLARQALVDVTLVCEGQKLRV----HKLVLASNSTYFEEILQKDL--SQEPIIFLKDLNFEILKAMVEFMYCGETTVP 97
Cdd:cd18248   13 NELRLSQQLCDVTLKVKYQDPKEefmaHKVVLASSSPYFKAMFTSGLreCGMEVVPIEGVHPCVMSRLIEFAYTASISVG 92

                         90       100
                 ....*....|....*....|....*
gi 383866442  98 YQLLSSLLTATKTFKVkelTSVVDA 122
Cdd:cd18248   93 EKCVLHVLPGAVMYQM---DSVVKA 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 383866442  19 ITEKFSELLARQALVDVTLVCEGQKLRVHKLVLASNSTYFEEILQKDLSQE--PIIFLKDLNFEILKAMVEFMYCGE 93
Cdd:cd18344   10 LTDDLGELWENSLFTDCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERlkNPIEIHDLDPQVFKEMMGFIYTGK 86

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383866442   9 VLQWAGHARFITEKFSELLARQALVDVTLVCEGQKLRVHKLVLASNSTYFEEILQKDLSQ--EPIIFLKDLNFEILKAMV 86
Cdd:cd18266    2 VYRWADHSNLVLQGLNEQRQRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREahQKEVELVGASYIGLKAVI 81

                 ....*..
gi 383866442  87 EFMYCGE 93
Cdd:cd18266   82 DFLYSSE 88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383866442  15 HARFITEKFSELLARQALVDVTLVCEGQKLRVHKLVLASNSTYFEEI---LQKDLSQEPIIFLKDLNFEILKAMVEFMYC 91
Cdd:cd18230    4 HYRHLLRELNEQRQHGILCDVCIIVEGKIFKAHKNVLLGSSRYFKTLycqVQKTSDQATVTHLDIVTAQGFKAIIDFMYS 83

                         90       100       110
                 ....*....|....*....|....*....|.
gi 383866442  92 GETTVPYQLLSSLLTATKTFkvkELTSVVDA 122
Cdd:cd18230   84 AHLALTSKNVIEVMSAASYL---QMTDIVQA 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383866442  15 HARFITekFSELLARQALVDVTLVCEGQKLRVHKLVLASNSTYFEEILQKDL--SQEPIIFLKDLNFEILKAMVEFMYCG 92
Cdd:cd18246   24 HDAFVS--MNRMRQRGLLCDIVLHVGTKEIKAHKVVLASCSPYFHAMFTNEMseSRQTHVTLHDIDPQALEQLVQYAYTA 101

                         90       100       110
                 ....*....|....*....|....*....|
gi 383866442  93 ETTVPYQLLSSLLTATKTFkvkELTSVVDA 122
Cdd:cd18246  102 EIVVGEGNVQTLLPAASLL---QLNGVRDA 128

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383866442  17 RFITEKFSELLARQALVDVTLVCEGQKLRVHKLVLASNSTYFEEIL-------QKDLSQEPIIFLKDLNFEILKAMVEFM 89
Cdd:cd18296    2 VDLDELPFPPEQELSFPDVCFQVEGHRFPCHKAFFCGRSDYFKALLrdhfaesEENNGSIPVVTLHDVSPEVFAIVLYYI 81

                         90
                 ....*....|....*...
gi 383866442  90 YCGETTVPYQLLSSLLTA 107
Cdd:cd18296   82 YTDDTDLPPENAYDVLYV 99

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383866442  32 LVDVTLVCEGQKLRVHKLVLASNSTYFEEILQKD--LSQEPIIFLKDLNFEILKAMVEFMYCGETTVPYQLLSSLLTATK 109
Cdd:cd18198   25 LCDVVILVQGREYRTHRSVLAACSQYFKKLFTSGavVDQQNVYEIDFVSPEALTALLEFAYTATLTVSTANVGDILSAAR 104

                         90
                 ....*....|
gi 383866442 110 TFKVKELTSV 119
Cdd:cd18198  105 LLEIPCVSHV 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383866442  34 DVTLVCEGQKLRVHKLVLASNSTYFEEIL---QKDLSQEPIIflkdlNFEILKAMVEFMYCGETTVPYQLLSSLLTATKT 110
Cdd:cd18229   20 DVTVRIHDASLRAHRCVLAAGSPFFHDKLllgHSEIEVPPVV-----PAQTVRQLVEFMYSGSLVVAQSEALQILTAASI 94

                         90
                 ....*....|.
gi 383866442 111 FKVKeltSVVD 121
Cdd:cd18229   95 LQIK---TVID 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383866442  15 HARFITEKFSELLARQALVDVTLVCEGQKLRVHKLVLASNSTYFEEILQKDlsqePIIFLKD--LNFEILKAMVEFMYCG 92
Cdd:cd18334    4 HAKQLLLQLNQQRAKGFLCDVIIVVENALFRAHKNILAASSMYFKSLVLHD----NLINLDTdmVNPTVFRQILDFIYTG 79