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Conserved domains on  [gi|383866446|ref|XP_003708681|]
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PREDICTED: CUE domain-containing protein 2 isoform X2 [Megachile rotundata]

Protein Classification

CUE domain-containing protein 2( domain architecture ID 10198899)

CUE domain-containing protein 2 (CUEDC2) is a novel negative regulator of progesterone receptor (PR) and functions to promote the progesterone-induced PR degradation by the ubiquitin-proteasome pathway

Gene Symbol:  CUEDC2
Gene Ontology:  GO:0043130
PubMed:  21976060|12628920

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CUE_CUED2 cd14367
CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins; CUEDC2 is a ...
 146-186 1.05e-15

CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins; CUEDC2 is a novel negative regulator of progesterone receptor (PR) and functions to promote the progesterone-induced PR degradation by the ubiquitin-proteasome pathway. It also acts as the regulator of JAK1/STAT3 signaling through inhibiting cytokine-induced phosphorylation of JAK1 and STAT3 and the subsequent STAT3 transcriptional activity. All members in this subfamily contain a CUE domain.


:

Pssm-ID: 270550  Cd Length: 42  Bit Score: 69.19  E-value: 1.05e-15
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 383866446 146 WHQVALLQEMFPAASLAEARHCLAVASGDIAKAAQLALHRQ 186
Cdd:cd14367    2 KDQVDLLLEMFPSCSSLEAKHCLAVAKGDLEEAVQLLLERQ 42
 
Name Accession Description Interval E-value
CUE_CUED2 cd14367
CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins; CUEDC2 is a ...
 146-186 1.05e-15

CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins; CUEDC2 is a novel negative regulator of progesterone receptor (PR) and functions to promote the progesterone-induced PR degradation by the ubiquitin-proteasome pathway. It also acts as the regulator of JAK1/STAT3 signaling through inhibiting cytokine-induced phosphorylation of JAK1 and STAT3 and the subsequent STAT3 transcriptional activity. All members in this subfamily contain a CUE domain.


Pssm-ID: 270550  Cd Length: 42  Bit Score: 69.19  E-value: 1.05e-15
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 383866446 146 WHQVALLQEMFPAASLAEARHCLAVASGDIAKAAQLALHRQ 186
Cdd:cd14367    2 KDQVDLLLEMFPSCSSLEAKHCLAVAKGDLEEAVQLLLERQ 42
 
Name Accession Description Interval E-value
CUE_CUED2 cd14367
CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins; CUEDC2 is a ...
 146-186 1.05e-15

CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins; CUEDC2 is a novel negative regulator of progesterone receptor (PR) and functions to promote the progesterone-induced PR degradation by the ubiquitin-proteasome pathway. It also acts as the regulator of JAK1/STAT3 signaling through inhibiting cytokine-induced phosphorylation of JAK1 and STAT3 and the subsequent STAT3 transcriptional activity. All members in this subfamily contain a CUE domain.


Pssm-ID: 270550  Cd Length: 42  Bit Score: 69.19  E-value: 1.05e-15
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 383866446 146 WHQVALLQEMFPAASLAEARHCLAVASGDIAKAAQLALHRQ 186
Cdd:cd14367    2 KDQVDLLLEMFPSCSSLEAKHCLAVAKGDLEEAVQLLLERQ 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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