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Conserved domains on  [gi|383866452|ref|XP_003708684|]
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PREDICTED: N-acetylglucosamine-1-phosphotransferase subunits alpha/beta isoform X1 [Megachile rotundata]

Protein Classification

Stealth_CR2 and Stealth_CR4 domain-containing protein( domain architecture ID 11246914)

protein containing domains Stealth_CR1, Stealth_CR2, Stealth_CR3, and Stealth_CR4

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Stealth_CR2 pfam11380
Stealth protein CR2, conserved region 2; Stealth_CR2 is the second of several highly conserved ...
 120-227 3.43e-63

Stealth protein CR2, conserved region 2; Stealth_CR2 is the second of several highly conserved regions on stealth proteins in metazoa and bacteria. There are up to four CR regions on all member proteins. CR2 carries a well-conserved NDD sequence-motif. The domain is found in tandem with CR1, CR3 and CR4 on both potential metazoan hosts and pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system.


:

Pssm-ID: 463267  Cd Length: 108  Bit Score: 206.16  E-value: 3.43e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383866452  120 RFNDKDELRYSLRSLEMYAPWVRHVYIVTNGQIPSWLDMDNPRLTLITHEDIFLNKSDLPTFSSPAIESHIHRIPGISDK 199
Cdd:pfam11380   1 RFRDRDELRYSLRSVEKYAPWVRKIYIVTDGQIPSWLNTSHPKIRIVDHKDIFPNESHLPTFNSHAIESNLHRIPGLSEH 80

                          90       100
                  ....*....|....*....|....*...
gi 383866452  200 FLYFNDDVMLGAEVWPEDFVTQVGGQKV 227
Cdd:pfam11380  81 FLYFNDDMFLGRPVKPEDFFTPDGLPKD 108
Stealth_CR4 pfam17103
Stealth protein CR4, conserved region 4; Stealth_CR4 is the fourth highly conserved region on ...
 639-696 3.17e-20

Stealth protein CR4, conserved region 4; Stealth_CR4 is the fourth highly conserved region on stealth proteins in metazoa and bacteria. There are four CR regions on mammalian members. CR4 carries a well-conserved CLND sequence-motif. The domain is found in tandem with CR1, CR2 and CR3 on both potential metazoan hosts and on pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains also appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system.


:

Pssm-ID: 465348  Cd Length: 55  Bit Score: 84.57  E-value: 3.17e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 383866452  639 DEIRRDPKKFICLNDDMDPLRRSEneiVRALLNDFYRSLYPLRSTFELPLQYRNLFAH 696
Cdd:pfam17103   1 DGIRRRRKKFFCLNDNIDPEVEEE---VKALLQDFLESLFPFPSPFELPPAYRNRFLY 55
Stealth_CR3 pfam17102
Stealth protein CR3, conserved region 3; Stealth_CR3 is the third of several highly conserved ...
 458-506 3.26e-15

Stealth protein CR3, conserved region 3; Stealth_CR3 is the third of several highly conserved regions on stealth proteins in metazoa and bacteria. There are up to four CR regions on all member proteins. The domain is found in tandem with CR1, CR2 and CR4 on both potential metazoan hosts and pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system.


:

Pssm-ID: 465347  Cd Length: 49  Bit Score: 70.24  E-value: 3.26e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 383866452  458 AHMPHLIDKWIATDMQTKFEHEFKKTSSHKVRNSEDMQFAFSYFYFLTS 506
Cdd:pfam17102   1 AHTPHPLRRSVLEEIEERFPEEFARTASHRFRSPDDLSMAFSYHHYYAE 49
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 240-267 6.35e-09

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


:

Pssm-ID: 459658  Cd Length: 35  Bit Score: 51.76  E-value: 6.35e-09
                          10        20        30
                  ....*....|....*....|....*....|..
gi 383866452  240 CP----WAWVGDGSCDPACNTTLCEFDGGDCD 267
Cdd:pfam00066   4 CPypycWDKFGNGVCDEECNNAECLWDGGDCS 35
Stealth_CR1 pfam17101
Stealth protein CR1, conserved region 1; Stealth_C1 is the first of several highly conserved ...
 86-113 2.28e-08

Stealth protein CR1, conserved region 1; Stealth_C1 is the first of several highly conserved regions on stealth proteins in metazoa and bacteria. There are up to four CR regions on all member proteins. CR1 carries a well-conserved IDVVYT sequence-motif. The domain is found in tandem with CR2, CR3 and CR4 on both potential metazoan hosts and pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system.


:

Pssm-ID: 465346  Cd Length: 29  Bit Score: 50.16  E-value: 2.28e-08
                          10        20
                  ....*....|....*....|....*...
gi 383866452   86 PIDVVYTWVNGSDPVFLKNLKKHVPIMD 113
Cdd:pfam17101   2 PIDVVYTWVNGSDPEWQAKKAKYLGKLG 29
 
Name Accession Description Interval E-value
Stealth_CR2 pfam11380
Stealth protein CR2, conserved region 2; Stealth_CR2 is the second of several highly conserved ...
 120-227 3.43e-63

Stealth protein CR2, conserved region 2; Stealth_CR2 is the second of several highly conserved regions on stealth proteins in metazoa and bacteria. There are up to four CR regions on all member proteins. CR2 carries a well-conserved NDD sequence-motif. The domain is found in tandem with CR1, CR3 and CR4 on both potential metazoan hosts and pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system.


Pssm-ID: 463267  Cd Length: 108  Bit Score: 206.16  E-value: 3.43e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383866452  120 RFNDKDELRYSLRSLEMYAPWVRHVYIVTNGQIPSWLDMDNPRLTLITHEDIFLNKSDLPTFSSPAIESHIHRIPGISDK 199
Cdd:pfam11380   1 RFRDRDELRYSLRSVEKYAPWVRKIYIVTDGQIPSWLNTSHPKIRIVDHKDIFPNESHLPTFNSHAIESNLHRIPGLSEH 80

                          90       100
                  ....*....|....*....|....*...
gi 383866452  200 FLYFNDDVMLGAEVWPEDFVTQVGGQKV 227
Cdd:pfam11380  81 FLYFNDDMFLGRPVKPEDFFTPDGLPKD 108
Stealth_CR4 pfam17103
Stealth protein CR4, conserved region 4; Stealth_CR4 is the fourth highly conserved region on ...
 639-696 3.17e-20

Stealth protein CR4, conserved region 4; Stealth_CR4 is the fourth highly conserved region on stealth proteins in metazoa and bacteria. There are four CR regions on mammalian members. CR4 carries a well-conserved CLND sequence-motif. The domain is found in tandem with CR1, CR2 and CR3 on both potential metazoan hosts and on pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains also appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system.


Pssm-ID: 465348  Cd Length: 55  Bit Score: 84.57  E-value: 3.17e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 383866452  639 DEIRRDPKKFICLNDDMDPLRRSEneiVRALLNDFYRSLYPLRSTFELPLQYRNLFAH 696
Cdd:pfam17103   1 DGIRRRRKKFFCLNDNIDPEVEEE---VKALLQDFLESLFPFPSPFELPPAYRNRFLY 55
Stealth_CR3 pfam17102
Stealth protein CR3, conserved region 3; Stealth_CR3 is the third of several highly conserved ...
 458-506 3.26e-15

Stealth protein CR3, conserved region 3; Stealth_CR3 is the third of several highly conserved regions on stealth proteins in metazoa and bacteria. There are up to four CR regions on all member proteins. The domain is found in tandem with CR1, CR2 and CR4 on both potential metazoan hosts and pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system.


Pssm-ID: 465347  Cd Length: 49  Bit Score: 70.24  E-value: 3.26e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 383866452  458 AHMPHLIDKWIATDMQTKFEHEFKKTSSHKVRNSEDMQFAFSYFYFLTS 506
Cdd:pfam17102   1 AHTPHPLRRSVLEEIEERFPEEFARTASHRFRSPDDLSMAFSYHHYYAE 49
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 240-267 6.35e-09

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 51.76  E-value: 6.35e-09
                          10        20        30
                  ....*....|....*....|....*....|..
gi 383866452  240 CP----WAWVGDGSCDPACNTTLCEFDGGDCD 267
Cdd:pfam00066   4 CPypycWDKFGNGVCDEECNNAECLWDGGDCS 35
Stealth_CR1 pfam17101
Stealth protein CR1, conserved region 1; Stealth_C1 is the first of several highly conserved ...
 86-113 2.28e-08

Stealth protein CR1, conserved region 1; Stealth_C1 is the first of several highly conserved regions on stealth proteins in metazoa and bacteria. There are up to four CR regions on all member proteins. CR1 carries a well-conserved IDVVYT sequence-motif. The domain is found in tandem with CR2, CR3 and CR4 on both potential metazoan hosts and pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system.


Pssm-ID: 465346  Cd Length: 29  Bit Score: 50.16  E-value: 2.28e-08
                          10        20
                  ....*....|....*....|....*...
gi 383866452   86 PIDVVYTWVNGSDPVFLKNLKKHVPIMD 113
Cdd:pfam17101   2 PIDVVYTWVNGSDPEWQAKKAKYLGKLG 29
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 236-266 4.91e-08

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 49.25  E-value: 4.91e-08
                           10        20        30
                   ....*....|....*....|....*....|.
gi 383866452   236 CSDVCPWAWVGDGSCDPACNTTLCEFDGGDC 266
Cdd:smart00004   8 CEDAQCWDKFGDGVCDEECNNAECLWDGGDC 38
 
Name Accession Description Interval E-value
Stealth_CR2 pfam11380
Stealth protein CR2, conserved region 2; Stealth_CR2 is the second of several highly conserved ...
 120-227 3.43e-63

Stealth protein CR2, conserved region 2; Stealth_CR2 is the second of several highly conserved regions on stealth proteins in metazoa and bacteria. There are up to four CR regions on all member proteins. CR2 carries a well-conserved NDD sequence-motif. The domain is found in tandem with CR1, CR3 and CR4 on both potential metazoan hosts and pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system.


Pssm-ID: 463267  Cd Length: 108  Bit Score: 206.16  E-value: 3.43e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383866452  120 RFNDKDELRYSLRSLEMYAPWVRHVYIVTNGQIPSWLDMDNPRLTLITHEDIFLNKSDLPTFSSPAIESHIHRIPGISDK 199
Cdd:pfam11380   1 RFRDRDELRYSLRSVEKYAPWVRKIYIVTDGQIPSWLNTSHPKIRIVDHKDIFPNESHLPTFNSHAIESNLHRIPGLSEH 80

                          90       100
                  ....*....|....*....|....*...
gi 383866452  200 FLYFNDDVMLGAEVWPEDFVTQVGGQKV 227
Cdd:pfam11380  81 FLYFNDDMFLGRPVKPEDFFTPDGLPKD 108
Stealth_CR4 pfam17103
Stealth protein CR4, conserved region 4; Stealth_CR4 is the fourth highly conserved region on ...
 639-696 3.17e-20

Stealth protein CR4, conserved region 4; Stealth_CR4 is the fourth highly conserved region on stealth proteins in metazoa and bacteria. There are four CR regions on mammalian members. CR4 carries a well-conserved CLND sequence-motif. The domain is found in tandem with CR1, CR2 and CR3 on both potential metazoan hosts and on pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains also appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system.


Pssm-ID: 465348  Cd Length: 55  Bit Score: 84.57  E-value: 3.17e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 383866452  639 DEIRRDPKKFICLNDDMDPLRRSEneiVRALLNDFYRSLYPLRSTFELPLQYRNLFAH 696
Cdd:pfam17103   1 DGIRRRRKKFFCLNDNIDPEVEEE---VKALLQDFLESLFPFPSPFELPPAYRNRFLY 55
Stealth_CR3 pfam17102
Stealth protein CR3, conserved region 3; Stealth_CR3 is the third of several highly conserved ...
 458-506 3.26e-15

Stealth protein CR3, conserved region 3; Stealth_CR3 is the third of several highly conserved regions on stealth proteins in metazoa and bacteria. There are up to four CR regions on all member proteins. The domain is found in tandem with CR1, CR2 and CR4 on both potential metazoan hosts and pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system.


Pssm-ID: 465347  Cd Length: 49  Bit Score: 70.24  E-value: 3.26e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 383866452  458 AHMPHLIDKWIATDMQTKFEHEFKKTSSHKVRNSEDMQFAFSYFYFLTS 506
Cdd:pfam17102   1 AHTPHPLRRSVLEEIEERFPEEFARTASHRFRSPDDLSMAFSYHHYYAE 49
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 240-267 6.35e-09

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 51.76  E-value: 6.35e-09
                          10        20        30
                  ....*....|....*....|....*....|..
gi 383866452  240 CP----WAWVGDGSCDPACNTTLCEFDGGDCD 267
Cdd:pfam00066   4 CPypycWDKFGNGVCDEECNNAECLWDGGDCS 35
Stealth_CR1 pfam17101
Stealth protein CR1, conserved region 1; Stealth_C1 is the first of several highly conserved ...
 86-113 2.28e-08

Stealth protein CR1, conserved region 1; Stealth_C1 is the first of several highly conserved regions on stealth proteins in metazoa and bacteria. There are up to four CR regions on all member proteins. CR1 carries a well-conserved IDVVYT sequence-motif. The domain is found in tandem with CR2, CR3 and CR4 on both potential metazoan hosts and pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system.


Pssm-ID: 465346  Cd Length: 29  Bit Score: 50.16  E-value: 2.28e-08
                          10        20
                  ....*....|....*....|....*...
gi 383866452   86 PIDVVYTWVNGSDPVFLKNLKKHVPIMD 113
Cdd:pfam17101   2 PIDVVYTWVNGSDPEWQAKKAKYLGKLG 29
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 236-266 4.91e-08

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 49.25  E-value: 4.91e-08
                           10        20        30
                   ....*....|....*....|....*....|.
gi 383866452   236 CSDVCPWAWVGDGSCDPACNTTLCEFDGGDC 266
Cdd:smart00004   8 CEDAQCWDKFGDGVCDEECNNAECLWDGGDC 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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