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Conserved domains on  [gi|528511250|ref|XP_005160551|]
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BTB/POZ domain-containing protein 6-B isoform X1 [Danio rerio]

Protein Classification

BTB/POZ domain-containing protein( domain architecture ID 13034831)

BTB (BR-C, ttk and bab)/POZ (Pox virus and Zinc finger) and PHR (PAM, highwire, and RPM) domain-containing protein similar to Homo sapiens BTB/POZ domain-containing (BTBD) proteins, such as BTBD1, BTBD2, BTBD3 and BTBD6, which may function as substrate-specific adaptors of an E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB_POZ_BTBD6 cd18349
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 125-233 3.94e-78

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also termed lens BTB domain protein, is a BTB-domain-containing Kelch-like protein required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349658 [Multi-domain]  Cd Length: 109  Bit Score: 240.65  E-value: 3.94e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 125 LMFNNELMADVHFVVGPPGASQKVPAHKYVLAVGSSVFGAMFYGDLAEGESEIHIPDVEPAAFLILLKYMYSDEIELEAD 204
Cdd:cd18349    1 LMFNNELMADVHFIVGPPGASQRVPAHKYVLAVGSSVFYAMFYGDLAEVKSEIHIPDVEPAAFLILLKYMYSDEIDLEAD 80

                         90       100
                 ....*....|....*....|....*....
gi 528511250 205 TVLATLYAAKKYIVPALAKACVTFLETSL 233
Cdd:cd18349   81 TVLATLYAAKKYIVPALAKACVNFLETSL 109
BACK super family cl28903
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 233-327 4.51e-66

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


The actual alignment was detected with superfamily member cd18525:

Pssm-ID: 475122  Cd Length: 95  Bit Score: 208.79  E-value: 4.51e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 233 LEAKNACVLLSQSRLFEEPELTLRCWEVIDAQAELALHSEGFCEIDLQTLEIILKRETLNTREAVVFQAALDWAVAECKR 312
Cdd:cd18525    1 LEAKNACVLLSQSRLFEEPELTQRCWEVIDAQAELALKSEGFCEIDQQTLEIILTRETLNTKEVVVFEAVLNWAEAECKR 80

                         90
                 ....*....|....*
gi 528511250 313 QGLGPTARNKRAVLG 327
Cdd:cd18525   81 QGLPPTARNKRNVLG 95
PHR pfam08005
PHR domain; This domain is called PHR as it was original found in the proteins PAM, highwire ...
 389-534 1.12e-50

PHR domain; This domain is called PHR as it was original found in the proteins PAM, highwire and RPM. This domain can be duplicated in the highwire, PFAM and PRM sequence. The C-terminal region of the protein BTBD1 includes the PHR domain and is known to interact with Topoisomerase I, an enzyme which relaxes DNA supercoils.


:

Pssm-ID: 462339  Cd Length: 150  Bit Score: 170.50  E-value: 1.12e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250  389 HRFQSSAYRsnqWRYRGRC-DSIQFAVDKRIFIAGLGLYGSSGGKAEYSVKIELK------RQGVTLAQNLTKFISDGSS 461
Cdd:pfam08005   1 NRFQSTGGG---WGYSGGSpDAIRFSVDRDIFLVGFGLYGSIGGPADYSVKIELIdgerweSLGEVLGENDTTFSSDGSN 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 528511250  462 NTFSVWFEHPVQVEQDTFYTVSAVLDGNElSYFGQEGMTEVQC-GKVTFQFQCSSDSTNGTGVQGGQIPELVFY 534
Cdd:pfam08005  78 DIFRVLFDEPVEIEPNVKYTASAKIKGPS-SYYGTNGLREVTCdGGVTFQFSSSSLSNNGTSVNRGQIPELLYY 150
 
Name Accession Description Interval E-value
BTB_POZ_BTBD6 cd18349
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 125-233 3.94e-78

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also termed lens BTB domain protein, is a BTB-domain-containing Kelch-like protein required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349658 [Multi-domain]  Cd Length: 109  Bit Score: 240.65  E-value: 3.94e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 125 LMFNNELMADVHFVVGPPGASQKVPAHKYVLAVGSSVFGAMFYGDLAEGESEIHIPDVEPAAFLILLKYMYSDEIELEAD 204
Cdd:cd18349    1 LMFNNELMADVHFIVGPPGASQRVPAHKYVLAVGSSVFYAMFYGDLAEVKSEIHIPDVEPAAFLILLKYMYSDEIDLEAD 80

                         90       100
                 ....*....|....*....|....*....
gi 528511250 205 TVLATLYAAKKYIVPALAKACVTFLETSL 233
Cdd:cd18349   81 TVLATLYAAKKYIVPALAKACVNFLETSL 109
BACK_BTBD6 cd18525
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 6 (BTBD6); ...
 233-327 4.51e-66

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also called lens BTB domain protein, is a BTB-domain-containing Kelch-like protein that is required for proper embryogenesis and plays an essential evolutionarily-conserved role during neuronal development.


Pssm-ID: 350600  Cd Length: 95  Bit Score: 208.79  E-value: 4.51e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 233 LEAKNACVLLSQSRLFEEPELTLRCWEVIDAQAELALHSEGFCEIDLQTLEIILKRETLNTREAVVFQAALDWAVAECKR 312
Cdd:cd18525    1 LEAKNACVLLSQSRLFEEPELTQRCWEVIDAQAELALKSEGFCEIDQQTLEIILTRETLNTKEVVVFEAVLNWAEAECKR 80

                         90
                 ....*....|....*
gi 528511250 313 QGLGPTARNKRAVLG 327
Cdd:cd18525   81 QGLPPTARNKRNVLG 95
PHR pfam08005
PHR domain; This domain is called PHR as it was original found in the proteins PAM, highwire ...
 389-534 1.12e-50

PHR domain; This domain is called PHR as it was original found in the proteins PAM, highwire and RPM. This domain can be duplicated in the highwire, PFAM and PRM sequence. The C-terminal region of the protein BTBD1 includes the PHR domain and is known to interact with Topoisomerase I, an enzyme which relaxes DNA supercoils.


Pssm-ID: 462339  Cd Length: 150  Bit Score: 170.50  E-value: 1.12e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250  389 HRFQSSAYRsnqWRYRGRC-DSIQFAVDKRIFIAGLGLYGSSGGKAEYSVKIELK------RQGVTLAQNLTKFISDGSS 461
Cdd:pfam08005   1 NRFQSTGGG---WGYSGGSpDAIRFSVDRDIFLVGFGLYGSIGGPADYSVKIELIdgerweSLGEVLGENDTTFSSDGSN 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 528511250  462 NTFSVWFEHPVQVEQDTFYTVSAVLDGNElSYFGQEGMTEVQC-GKVTFQFQCSSDSTNGTGVQGGQIPELVFY 534
Cdd:pfam08005  78 DIFRVLFDEPVEIEPNVKYTASAKIKGPS-SYYGTNGLREVTCdGGVTFQFSSSSLSNNGTSVNRGQIPELLYY 150
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 126-233 1.83e-24

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 97.71  E-value: 1.83e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250  126 MFNNELMADVHFVVGppgaSQKVPAHKYVLAVGSSVFGAMFYGDLAEGE-SEIHIPDVEPAAFLILLKYMYSDEIeLEAD 204
Cdd:pfam00651   4 LREQGELCDVTLVVG----DKEFRAHKAVLAACSPYFKALFSGQESESSvSEITLDDVSPEDFEALLEFMYTGKL-ISEE 78

                          90       100
                  ....*....|....*....|....*....
gi 528511250  205 TVLATLYAAKKYIVPALAKACVTFLETSL 233
Cdd:pfam00651  79 NVDDLLAAADKLQIPSLVDKCEEFLIKSL 107
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 134-233 2.54e-21

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 88.52  E-value: 2.54e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250   134 DVHFVVGppgaSQKVPAHKYVLAVGSSVFGAMFYGDLAE-GESEIHIPDVEPAAFLILLKYMYSDEIELEADTVLATLYA 212
Cdd:smart00225   1 DVTLVVG----GKKFHAHKAVLAAHSPYFKALFSSDFKEsDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLEL 76

                           90       100
                   ....*....|....*....|.
gi 528511250   213 AKKYIVPALAKACVTFLETSL 233
Cdd:smart00225  77 ADYLQIPGLVELCEEFLLKLL 97
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 239-345 2.29e-12

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 63.13  E-value: 2.29e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250   239 CV-LLSQSRLFEEPELTLRCWEVIDAQAELALHSEGFCEIDLQTLEIILKRETLN-TREAVVFQAALDWAVAECKRQglg 316
Cdd:smart00875   1 CLgIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNvSSEEEVFEAVLRWVKHDPEKR--- 77

                           90       100
                   ....*....|....*....|....*....
gi 528511250   317 ptarnkRAVLGKALYLVRIPTMTLEEFAN 345
Cdd:smart00875  78 ------REHLPELLEHVRLPLLSPDYLLE 100
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 251-345 4.91e-05

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 42.53  E-value: 4.91e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250  251 PELTLRCWEVIDAQAELALHSEGFCEIDLQTLEIILKRETLNT-REAVVFQAALDWAVAECKRqglgptarnKRAVLGKA 329
Cdd:pfam07707  14 TELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVpSEEEVFEAVIRWVKHDVER---------RKKHLPEL 84

                          90
                  ....*....|....*.
gi 528511250  330 LYLVRIPTMTLEEFAN 345
Cdd:pfam07707  85 LSAVRLPLLSPQYLLN 100
PHA03098 PHA03098
kelch-like protein; Provisional
 147-240 8.72e-05

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 45.14  E-value: 8.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 147 KVPAHKYVLAVGSSVFGAMFYGDLAEGESEIHIpDVEpaAFLILLKYMYSDEIELEADTVLATLYAAKKYIVPALAKACV 226
Cdd:PHA03098  22 IIKVHKIILSSSSEYFKKMFKNNFKENEINLNI-DYD--SFNEVIKYIYTGKINITSNNVKDILSIANYLIIDFLINLCI 98

                         90
                 ....*....|....
gi 528511250 227 TFLETSLEAKNaCV 240
Cdd:PHA03098  99 NYIIKIIDDNN-CI 111
 
Name Accession Description Interval E-value
BTB_POZ_BTBD6 cd18349
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 125-233 3.94e-78

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also termed lens BTB domain protein, is a BTB-domain-containing Kelch-like protein required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349658 [Multi-domain]  Cd Length: 109  Bit Score: 240.65  E-value: 3.94e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 125 LMFNNELMADVHFVVGPPGASQKVPAHKYVLAVGSSVFGAMFYGDLAEGESEIHIPDVEPAAFLILLKYMYSDEIELEAD 204
Cdd:cd18349    1 LMFNNELMADVHFIVGPPGASQRVPAHKYVLAVGSSVFYAMFYGDLAEVKSEIHIPDVEPAAFLILLKYMYSDEIDLEAD 80

                         90       100
                 ....*....|....*....|....*....
gi 528511250 205 TVLATLYAAKKYIVPALAKACVTFLETSL 233
Cdd:cd18349   81 TVLATLYAAKKYIVPALAKACVNFLETSL 109
BTB_POZ_BTBD3_6 cd18282
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 126-233 7.49e-73

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349591 [Multi-domain]  Cd Length: 108  Bit Score: 226.89  E-value: 7.49e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 126 MFNNELMADVHFVVGPPGASQKVPAHKYVLAVGSSVFGAMFYGDLAEGESEIHIPDVEPAAFLILLKYMYSDEIELEADT 205
Cdd:cd18282    1 MFNNELMADVHFIVGPPGGTQRIPAHKYVLATGSSVFYAMFYGGLAENKNEIEIPDVEPAAFLNLLRYLYCDEIDLEPDT 80

                         90       100
                 ....*....|....*....|....*...
gi 528511250 206 VLATLYAAKKYIVPALAKACVTFLETSL 233
Cdd:cd18282   81 VLATLYAAKKYLVPHLARACVQFLETSL 108
BTB_POZ_BTBD3 cd18348
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 112-242 3.23e-70

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 3 (BTBD3); BTBD3 is a BTB-domain-containing Kelch-like protein that controls dendrite orientation toward active axons in the mammalian neocortex. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349657 [Multi-domain]  Cd Length: 131  Bit Score: 221.05  E-value: 3.23e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 112 WQSTHPTLRERNALMFNNELMADVHFVVGPPGASQKVPAHKYVLAVGSSVFGAMFYGDLAEGESEIHIPDVEPAAFLILL 191
Cdd:cd18348    1 WQGLYPTIRERNAVMFNNDLMADIHFVVGPPGGTQRLPGHKYVLAVGSSVFHAMFYGELAEDKDEIRIPDVEPAAFLAML 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 528511250 192 KYMYSDEIELEADTVLATLYAAKKYIVPALAKACVTFLETSLEAKNACVLL 242
Cdd:cd18348   81 KYIYCDEIDLAADTVLATLYAAKKYIVPHLARACVNFLETSLSAKNACVLL 131
BACK_BTBD6 cd18525
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 6 (BTBD6); ...
 233-327 4.51e-66

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also called lens BTB domain protein, is a BTB-domain-containing Kelch-like protein that is required for proper embryogenesis and plays an essential evolutionarily-conserved role during neuronal development.


Pssm-ID: 350600  Cd Length: 95  Bit Score: 208.79  E-value: 4.51e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 233 LEAKNACVLLSQSRLFEEPELTLRCWEVIDAQAELALHSEGFCEIDLQTLEIILKRETLNTREAVVFQAALDWAVAECKR 312
Cdd:cd18525    1 LEAKNACVLLSQSRLFEEPELTQRCWEVIDAQAELALKSEGFCEIDQQTLEIILTRETLNTKEVVVFEAVLNWAEAECKR 80

                         90
                 ....*....|....*
gi 528511250 313 QGLGPTARNKRAVLG 327
Cdd:cd18525   81 QGLPPTARNKRNVLG 95
BTB_POZ_BTBD1_2 cd18281
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 112-237 1.27e-59

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349590 [Multi-domain]  Cd Length: 127  Bit Score: 193.04  E-value: 1.27e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 112 WQSTHPTLRERNALMFNNELMADVHFVVGPPGASQKVPAHKYVLAVGSSVFGAMFYGDLAEGESEIHIPDVEPAAFLILL 191
Cdd:cd18281    2 WQASKTTVKERFAFLFNNETLSDVHFIVGKGDNEQRIPAHKFVLSIGSAVFDAMFNGGMATTSAEIELPDVEPAAFLALL 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 528511250 192 KYMYSDEIELEADTVLATLYAAKKYIVPALAKACVTFLETSLEAKN 237
Cdd:cd18281   82 RFLYSDEVQIGPETVMTTLYTAKKYAVPALESACVEFLKKNLSSDN 127
BACK_BTBD3_like cd18488
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing proteins, BTBD3 and ...
 233-327 3.18e-59

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This subfamily includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionarily-conserved role during neuronal development.


Pssm-ID: 350563  Cd Length: 95  Bit Score: 191.04  E-value: 3.18e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 233 LEAKNACVLLSQSRLFEEPELTLRCWEVIDAQAELALHSEGFCEIDLQTLEIILKRETLNTREAVVFQAALDWAVAECKR 312
Cdd:cd18488    1 LSARNACVLLSQSRLFEEPELMQRCWEVIDAQAELALKSEGFTEIDYKTLESILRRETLNAKESVVFEAALRWAEAECQR 80

                         90
                 ....*....|....*
gi 528511250 313 QGLGPTARNKRAVLG 327
Cdd:cd18488   81 RGLEPTPENKRKVLG 95
BACK_BTBD3 cd18524
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 3 (BTBD3); ...
 233-327 2.98e-51

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 3 (BTBD3); BTBD3 is a BTB-domain-containing Kelch-like protein that controls dendrite orientation toward active axons in mammalian neocortex.


Pssm-ID: 350599  Cd Length: 95  Bit Score: 170.29  E-value: 2.98e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 233 LEAKNACVLLSQSRLFEEPELTLRCWEVIDAQAELALHSEGFCEIDLQTLEIILKRETLNTREAVVFQAALDWAVAECKR 312
Cdd:cd18524    1 LSAKNACVLLSQSCLFEEPDLTQRCWEVIDAQAELALKSEGFCDIDFQTLESILRRETLNAKEIVVFEAALNWAEVECQR 80

                         90
                 ....*....|....*
gi 528511250 313 QGLGPTARNKRAVLG 327
Cdd:cd18524   81 QELQPTIENKRKVLG 95
PHR pfam08005
PHR domain; This domain is called PHR as it was original found in the proteins PAM, highwire ...
 389-534 1.12e-50

PHR domain; This domain is called PHR as it was original found in the proteins PAM, highwire and RPM. This domain can be duplicated in the highwire, PFAM and PRM sequence. The C-terminal region of the protein BTBD1 includes the PHR domain and is known to interact with Topoisomerase I, an enzyme which relaxes DNA supercoils.


Pssm-ID: 462339  Cd Length: 150  Bit Score: 170.50  E-value: 1.12e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250  389 HRFQSSAYRsnqWRYRGRC-DSIQFAVDKRIFIAGLGLYGSSGGKAEYSVKIELK------RQGVTLAQNLTKFISDGSS 461
Cdd:pfam08005   1 NRFQSTGGG---WGYSGGSpDAIRFSVDRDIFLVGFGLYGSIGGPADYSVKIELIdgerweSLGEVLGENDTTFSSDGSN 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 528511250  462 NTFSVWFEHPVQVEQDTFYTVSAVLDGNElSYFGQEGMTEVQC-GKVTFQFQCSSDSTNGTGVQGGQIPELVFY 534
Cdd:pfam08005  78 DIFRVLFDEPVEIEPNVKYTASAKIKGPS-SYYGTNGLREVTCdGGVTFQFSSSSLSNNGTSVNRGQIPELLYY 150
BTB_POZ_BTBD1 cd18346
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 111-237 4.78e-48

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein that is expressed in skeletal muscle and interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. BTBD1 may serve as substrate-specific adaptor of an E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349655 [Multi-domain]  Cd Length: 133  Bit Score: 162.92  E-value: 4.78e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 111 SWQSTHPTLRERNALMFNNELMADVHFVVG------PPGASQKVPAHKYVLAVGSSVFGAMFYGDLAEGESEIHIPDVEP 184
Cdd:cd18346    1 NWQATKSSLKERFAFLFNNELLSDVRFVVGkgrprgPGPGAQRIPAHRFVLAAGSAVFDAMFNGGMATTSAEIELPDVEP 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 528511250 185 AAFLILLKYMYSDEIELEADTVLATLYAAKKYIVPALAKACVTFLETSLEAKN 237
Cdd:cd18346   81 AAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADN 133
BTB_POZ_BTBD2 cd18347
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 111-237 5.86e-46

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349656 [Multi-domain]  Cd Length: 127  Bit Score: 157.16  E-value: 5.86e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 111 SWQSTHPTLRERNALMFNNELMADVHFVVGPPGASQKVPAHKYVLAVGSSVFGAMFYGDLAEGESEIHIPDVEPAAFLIL 190
Cdd:cd18347    1 NWQATKPTVQERFAFLFNNEVLSDVHFLVGKGLGSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTEIELPDVEPAAFLAL 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 528511250 191 LKYMYSDEIELEADTVLATLYAAKKYIVPALAKACVTFLETSLEAKN 237
Cdd:cd18347   81 LKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADN 127
BACK_BTBD1_like cd18487
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing proteins, BTBD1 and ...
 233-327 6.02e-33

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This subfamily includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme in cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta.


Pssm-ID: 350562  Cd Length: 95  Bit Score: 120.92  E-value: 6.02e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 233 LEAKNACVLLSQSRLFEEPELTLRCWEVIDAQAELALHSEGFCEIDLQTLEIILKRETLNTREAVVFQAALDWAVAECKR 312
Cdd:cd18487    1 LSSDNAFMLLTQARLFDEPQLASLCLETIDKNTAEALAAEGFTDIDLDTLCVVLERDTLGIRECKLFQAVLRWAEAECQR 80

                         90
                 ....*....|....*
gi 528511250 313 QGLGPTARNKRAVLG 327
Cdd:cd18487   81 QGLSVTPENQRKVLG 95
BACK_BTBD1 cd18522
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 1 (BTBD1); ...
 233-339 1.70e-31

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein specifically expressed in skeletal muscle. It interacts with DNA topoisomerase 1 (Topo1), a key enzyme in cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. It may serve as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.


Pssm-ID: 350597  Cd Length: 107  Bit Score: 117.48  E-value: 1.70e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 233 LEAKNACVLLSQSRLFEEPELTLRCWEVIDAQAELALHSEGFCEIDLQTLEIILKRETLNTREAVVFQAALDWAVAECKR 312
Cdd:cd18522    1 LRADNAFMLLTQARLFDEPQLASLCLDTIDKSTMDAISAEGFTDIDLDTLCAVLERDTLSIRESRLFGAVVRWAEAECQR 80

                         90       100
                 ....*....|....*....|....*..
gi 528511250 313 QGLGPTARNKRAVLGKALYLVRIPTMT 339
Cdd:cd18522   81 QQLPVTSENKQKVLGKALSLIRFPLMT 107
BACK_BTBD2 cd18523
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 2 (BTBD2); ...
 233-338 5.35e-31

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme in cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta.


Pssm-ID: 350598  Cd Length: 106  Bit Score: 115.85  E-value: 5.35e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 233 LEAKNACVLLSQSRLFEEPELTLRCWEVIDAQAELALHSEGFCEIDLQTLEIILKRETLNTREAVVFQAALDWAVAECKR 312
Cdd:cd18523    1 LRADNAFMLLTQARLFDEPQLASLCLENIDKNTSDAINAEGFTDIDLDTLVAVLERDTLGIREVRLFNAVVRWAEAECQR 80

                         90       100
                 ....*....|....*....|....*.
gi 528511250 313 QGLGPTARNKRAVLGKALYLVRIPTM 338
Cdd:cd18523   81 QQLQVTPENKRKVLGKALSLIRFPLM 106
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 126-233 1.83e-24

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 97.71  E-value: 1.83e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250  126 MFNNELMADVHFVVGppgaSQKVPAHKYVLAVGSSVFGAMFYGDLAEGE-SEIHIPDVEPAAFLILLKYMYSDEIeLEAD 204
Cdd:pfam00651   4 LREQGELCDVTLVVG----DKEFRAHKAVLAACSPYFKALFSGQESESSvSEITLDDVSPEDFEALLEFMYTGKL-ISEE 78

                          90       100
                  ....*....|....*....|....*....
gi 528511250  205 TVLATLYAAKKYIVPALAKACVTFLETSL 233
Cdd:pfam00651  79 NVDDLLAAADKLQIPSLVDKCEEFLIKSL 107
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 132-216 1.31e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 94.54  E-value: 1.31e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 132 MADVHFVVGppgaSQKVPAHKYVLAVGSSVFGAMFYGDLAE-GESEIHIPDVEPAAFLILLKYMYSDEIELEADTVLATL 210
Cdd:cd18186    1 LCDVTLVVG----GREFPAHRAVLAARSPYFRAMFSSGMKEsSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELL 76


                 ....*.
gi 528511250 211 YAAKKY 216
Cdd:cd18186   77 AAADKL 82
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 126-229 1.90e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 89.23  E-value: 1.90e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 126 MFNNELMADVHFVVGPPGasQKVPAHKYVLAVGSSVFGAMFYGDLAEGE--SEIHIPDVEPAAFLILLKYMYSDEIELEA 203
Cdd:cd18294    8 LINNPEFSDVKFLVGPER--QEIFAHKCILAARCEVFRAMFLTGPQKEStqSPLVLSDIEPEVFRAVLEFIYTNCVTLSN 85

                         90       100
                 ....*....|....*....|....*.
gi 528511250 204 DTVLATLYAAKKYIVPALAKACVTFL 229
Cdd:cd18294   86 HTVIEVLAAAVEYGLDELRKLCERFI 111
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 134-233 2.54e-21

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 88.52  E-value: 2.54e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250   134 DVHFVVGppgaSQKVPAHKYVLAVGSSVFGAMFYGDLAE-GESEIHIPDVEPAAFLILLKYMYSDEIELEADTVLATLYA 212
Cdd:smart00225   1 DVTLVVG----GKKFHAHKAVLAAHSPYFKALFSSDFKEsDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLEL 76

                           90       100
                   ....*....|....*....|.
gi 528511250   213 AKKYIVPALAKACVTFLETSL 233
Cdd:smart00225  77 ADYLQIPGLVELCEEFLLKLL 97
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 126-229 1.34e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 84.60  E-value: 1.34e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 126 MFNNELMADVHFVVGppgaSQKVPAHKYVLAVGSSVFGAMFYGDLAEG-ESEIHIPDVEPAAFLILLKYMYSDEIEL--- 201
Cdd:cd18287   16 LFLNEEYSDVTFVVE----EKRFPAHRVILAARSEYFRALLYGGMRESqQSEIELKDTNAEAFKALLKYIYTGRLTLtdl 91

                         90       100
                 ....*....|....*....|....*...
gi 528511250 202 EADTVLATLYAAKKYIVPALAKACVTFL 229
Cdd:cd18287   92 KEDVLLDVLGLAHQYGFEELEAAISDYL 119
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 132-237 3.14e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 77.41  E-value: 3.14e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 132 MADVHFVVGppgaSQKVPAHKYVLAVGSSVFGAMFYGDLAEG-ESEIHIPDVEPAAFLILLKYMYSDEIELEADTVLATL 210
Cdd:cd18234    1 LCDVILIAG----DRRIPAHRLVLSAVSDYFAAMFTNDVREAtEEEIKLKDVDPDALWTLVQYCYTGRLELKEDNVESLL 76

                         90       100
                 ....*....|....*....|....*..
gi 528511250 211 YAAKKYIVPALAKACVTFLETSLEAKN 237
Cdd:cd18234   77 ATACLLQLSEVVEACCGFLMKQLHPSN 103
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 122-234 7.35e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 76.65  E-value: 7.35e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 122 RNALMFNNEL-----MADVHFVVGPPGASQKVPAHKYVLAVGSSVFGAMFYGDLAE-GESEIHIPDVEPAAFLILLKYMY 195
Cdd:cd18248    6 KEAFQIMNELrlsqqLCDVTLKVKYQDPKEEFMAHKVVLASSSPYFKAMFTSGLREcGMEVVPIEGVHPCVMSRLIEFAY 85

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 528511250 196 SDEIELEADTVLATLYAAKKYIVPALAKACVTFLETSLE 234
Cdd:cd18248   86 TASISVGEKCVLHVLPGAVMYQMDSVVKACCDFLEQQLD 124
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 125-233 1.09e-16

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 75.74  E-value: 1.09e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 125 LMFNNELMADVHFVVgppgASQKVPAHKYVLAVGSSVFGAMFYGDLAEGES-EIHIPDVEPAAFLILLKYMYSDEI-ELE 202
Cdd:cd18300    2 LFLNKGLFSDVTFIV----EDGTIPAHKALLVARCDVMAAMFGGNFRESSAkEVELPGVSKETFLALLEYLYTDQApILE 77

                         90       100       110
                 ....*....|....*....|....*....|.
gi 528511250 203 ADTVLATLYAAKKYIVPALAKACVTFLETSL 233
Cdd:cd18300   78 DGDCVGLIVLANRLCLPRLVALCEQYIVKEL 108
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 126-237 1.32e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 75.99  E-value: 1.32e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 126 MFNNELMADVHFVVgppgASQKVPAHKYVLAVGSSVFGAMFYGDLAEGES-EIHIPDVEPAAFLILLKYMYSDEIELEAD 204
Cdd:cd18237   15 MRKQKTLCDVILIV----EGREIKAHRVVLAAASHFFHLMFTSNMTESKSsEVELKDAEPDIIELLVEFAYTARISVNSN 90

                         90       100       110
                 ....*....|....*....|....*....|...
gi 528511250 205 TVLATLYAAKKYIVPALAKACVTFLETSLEAKN 237
Cdd:cd18237   91 NVQSLLDAANQYQIEPVKKMCVDFLKEQLDASN 123
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 116-238 2.13e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 75.40  E-value: 2.13e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 116 HPTLRErnalMFNNELMADVHFVVGppgaSQKVPAHKYVLAVGSSVFGAMFYGDLAEG-ESEIHIPDVEPAAFLILLKYM 194
Cdd:cd18238    3 FKVLHQ----FYENGELCDVTLKVG----EKSIHCHRLVLACVSPYFRAMFTSEMAESkQDSITIKDIDEEAVELLVDFA 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 528511250 195 YSDEIELEADTVLATLYAAKKYIVPALAKACVTFLETSLEAKNA 238
Cdd:cd18238   75 YTGKLTLTVDNVQSLLYAASLLQVEEVAKACCEFMKDHLHPSNC 118
BTB_POZ_KLHL2-like cd18235
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 126-233 8.87e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349544 [Multi-domain]  Cd Length: 121  Bit Score: 73.62  E-value: 8.87e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 126 MFNNELMADVHFVVGppgaSQKVPAHKYVLAVGSSVFGAMFYGDLAEGESE-IHIPDVEPAAFLILLKYMYSDEIELEAD 204
Cdd:cd18235   15 LRKQNLLCDVILVAD----GVEIPAHRVVLASCSPYFHAMFTGDLSESRANrVTLQDVDGKALLLLIDYVYTAEIQVTEE 90

                         90       100
                 ....*....|....*....|....*....
gi 528511250 205 TVLATLYAAKKYIVPALAKACVTFLETSL 233
Cdd:cd18235   91 NVQVLLPAANLLQLTDVRDACCDFLQSQL 119
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 127-225 1.05e-15

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 72.76  E-value: 1.05e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 127 FNNELMADVHFVVGppgaSQKVPAHKYVLAVGSSVFGAMFYGDLAEG-ESEIHIPDVEPAAFLILLKYMYSDEIELEADT 205
Cdd:cd18314    1 YNDSEFSDVVLCVG----DRKFFAHRIVLCARSPVFRSMLTGSMIESnLKEVTLEDVEPEIFETVLKYMYTGQVTLSEEN 76

                         90       100
                 ....*....|....*....|
gi 528511250 206 VLATLYAAKKYIVPALAKAC 225
Cdd:cd18314   77 VLDLLMLASKYQVPDLEKLC 96
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 116-228 8.63e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 70.39  E-value: 8.63e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 116 HPTLRERNALMFNNELMADVHFVVGppgaSQKVPAHKYVLAVGSSVFGAMFYGDLAEGESEIHIPDVEP----AAFLILL 191
Cdd:cd18292    1 SREFLQDIAQLYNNEELSDIVLRVG----GKVFHAHRLILAKSSDVFRVMLSNDWWSESKQSEIELVEDpecaAVFEKFL 76

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 528511250 192 KYMYSDEIELEADTVLATLYAAKKYIVPALAKACVTF 228
Cdd:cd18292   77 RYLYTGQISVNLETALPLLMLADKYNVTDLKQLCVDF 113
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 133-225 2.73e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 69.28  E-value: 2.73e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 133 ADVHFVVgppgASQKVPAHKYVLAVGSSVFGAMFYGDLAEG-ESEIHIPDVEPAAFLILLKYMYSDEI----------EL 201
Cdd:cd18280   15 ADVTFNV----DGEKFRAHKLVLAARSPVFRSMLFGPMREEnEGEIVIEDVEPPVFKALLHFIYKDELpddvepagsdSS 90

                         90       100
                 ....*....|....*....|....*.
gi 528511250 202 EADTVLAT--LYAAKKYIVPALAKAC 225
Cdd:cd18280   91 SLDTTMAQhlLAAADRYALERLRLLC 116
BTB_POZ_Rank-5 cd18303
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 126-240 2.92e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349612 [Multi-domain]  Cd Length: 120  Bit Score: 69.27  E-value: 2.92e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 126 MFNNELMADVHFVVgppgASQKVPAHKYVLAVGSSVFGAmfyGDLAEgESEIHIPDVEPAAFLILLKYMYSDEIELEADT 205
Cdd:cd18303   12 LFDKELYSDITIKL----ADKSIPAHKFVLAARSEKWSN---ENLAS-TNELDLSDISYEVVLALLRWLYTDELDLTLDD 83

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 528511250 206 VLAT--LYAAKKYIVPALAKACVTFLETSLEAKNaCV 240
Cdd:cd18303   84 EFLLelMKAAKRFQLTDLVERCERALMSSVNVDN-CI 119
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 134-237 3.03e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 69.42  E-value: 3.03e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 134 DVHFVVGppgaSQKVPAHKYVLAVGSSVFGAMFYGDLAE-GESEIHIPDVEPAAFLILLKYMYSDEIELEADTVLATLYA 212
Cdd:cd18265   25 DVVLLVD----GKDFPCHRATLSANSAYFRAMFGGHLKEsRQAVVEIQKVSAAAMEVLLDYMYGGGLRIQEDNVESVLEA 100

                         90       100
                 ....*....|....*....|....*
gi 528511250 213 AKKYIVPALAKACVTFLETSLEAKN 237
Cdd:cd18265  101 SDLLQVSKLREACVRFLEGQLHPCN 125
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 125-234 4.81e-14

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 68.86  E-value: 4.81e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 125 LMFNNELM---ADVHFVVgppgASQKVPAHKYVLAVGSSVFGAMFYGDLAEGESE------IHIPDVEPAAFLILLKYMY 195
Cdd:cd18296    7 LPFPPEQElsfPDVCFQV----EGHRFPCHKAFFCGRSDYFKALLRDHFAESEENngsipvVTLHDVSPEVFAIVLYYIY 82

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 528511250 196 SDEIELEADTVLATLYAAKKYIVPALAKACVTFLETSLE 234
Cdd:cd18296   83 TDDTDLPPENAYDVLYVADMYLLPGLKRLCGTVLAQSLD 121
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 146-237 3.28e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 66.78  E-value: 3.28e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 146 QKVPAHKYVLAVGSSVFGAMFYGDLAEGES-EIHIPDVEPAAFLILLKYMYSDEIELEADTVLATLYAAKKYIVPALAKA 224
Cdd:cd18340   37 KEFPCHRLVLAACSPYFRAMFLSDLEESKKrEIVLEDVDPDVMGKILHYIYTSEIEITEQNVQDIFAAANMFQIPSIFTV 116

                         90
                 ....*....|...
gi 528511250 225 CVTFLETSLEAKN 237
Cdd:cd18340  117 CVSFLQKRLCLSN 129
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 127-237 7.96e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 64.99  E-value: 7.96e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 127 FNNELMADVHFVV-GPPgasqkVPAHKYVLAVGSSVFGAMFYGDLAEG-ESEIHIPDVEPAAFLILLKYMYS---DEIEL 201
Cdd:cd18297    7 VNNPEMSDVTFLVeGRP-----FYAHKIVLVTASDRFKSMLSSGSTEAqTPVIEIPDIRYDIFQLMMQYLYTggvESLDV 81

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 528511250 202 EADTVLATLYAAKKYIVPALAKACVTFLETSLEAKN 237
Cdd:cd18297   82 AQDDALELLRAASFFQLDGLKRHCEILLSQQIDLDN 117
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 134-238 8.39e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 65.12  E-value: 8.39e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 134 DVHFVVGPpgasQKVPAHKYVLAVGSSVFGAMFYGDLAE-GESEIHIPDVEPAAFLILLKYMYSDEIELEADTVLATLYA 212
Cdd:cd18256   22 DVQLQVGM----ELFSVHRLVLAASSPYFAALFAGGMSEsSKDVVQIHGVEPDIFHILLDFIYTGVVEVTVSNVQELLVA 97

                         90       100
                 ....*....|....*....|....*.
gi 528511250 213 AKKYIVPALAKACVTFLETSLEAKNA 238
Cdd:cd18256   98 ADMLQLTEVVEICCEFLKGQLHPSNC 123
BTB_POZ_KLHL40-like cd18269
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 149-237 1.35e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349578 [Multi-domain]  Cd Length: 133  Bit Score: 64.73  E-value: 1.35e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 149 PAHKYVLAVGSSVFGAMFYGDLAEGES-EIHIPDVEPAAFLILLKYMYSDEIELEADTVLATLYAAKKYIVPALAKACVT 227
Cdd:cd18269   40 PCHRLVLAACSPYFRAMFLSDLEESKKkEVVLEDVDPDVMGMILKYLYTSEIDLNDQNVQDIFALASRFQIPSIFTVCVS 119

                         90
                 ....*....|
gi 528511250 228 FLETSLEAKN 237
Cdd:cd18269  120 YLQKRLSLSN 129
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 123-237 1.89e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 64.27  E-value: 1.89e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 123 NALMFNNELmADVHFVVGppgaSQKVPAHKYVLAVGSSVFGAMFYGDLAEGE-SEIHIPDVEPAAFLILLKYMYSDEIEL 201
Cdd:cd18240    9 NELRLEGKL-CDVVIRVN----GVEFPAHRNILCACSPYFRALFTNGWNETEkKVYKIPGVSPEMMELIIEYAYTRTVPI 83

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 528511250 202 EADTVLATLYAAKKYIVPALAKACVTFLETSLEAKN 237
Cdd:cd18240   84 TAENVEELLPAADQFNIMGIVKACCDFLEDQLCPEN 119
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 239-345 2.29e-12

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 63.13  E-value: 2.29e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250   239 CV-LLSQSRLFEEPELTLRCWEVIDAQAELALHSEGFCEIDLQTLEIILKRETLN-TREAVVFQAALDWAVAECKRQglg 316
Cdd:smart00875   1 CLgIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNvSSEEEVFEAVLRWVKHDPEKR--- 77

                           90       100
                   ....*....|....*....|....*....
gi 528511250   317 ptarnkRAVLGKALYLVRIPTMTLEEFAN 345
Cdd:smart00875  78 ------REHLPELLEHVRLPLLSPDYLLE 100
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 134-238 2.73e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 63.82  E-value: 2.73e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 134 DVHFVVGppgaSQKVPAHKYVLAVGSSVFGAMFYGDlAEGESEIH--IPDVEPAAFLILLKYMYSDEIELEADTVLATLY 211
Cdd:cd18306   20 DVILQVG----GHEIPAHRAVLACASPYLFELFSSD-SDGESILTvkLDGLDPDAVEVLVNYAYTSRLEVPADLVKSVYS 94

                         90       100
                 ....*....|....*....|....*..
gi 528511250 212 AAKKYIVPALAKACVTFLETSLEAKNA 238
Cdd:cd18306   95 AAKKLKMDRVKKACGDFLLEKLTPQNC 121
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 126-213 5.96e-12

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 62.66  E-value: 5.96e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 126 MFNNELMADVHFVVGppgaSQKVPAHKYVLAVGSSVFGAMFYGDLAEGES-EIHIPDVEPAAFLILLKYMYSDEIELEAD 204
Cdd:cd18286   11 LFLNGEDSDITIKVD----GKTFKAHRCILCARSSYFAAMLSGSWAESNSsEITLTGVSHAAVSFVLLFIYGGVLDLPDD 86


                 ....*....
gi 528511250 205 TVLATLYAA 213
Cdd:cd18286   87 VNLGELLSL 95
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 123-237 7.13e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 62.46  E-value: 7.13e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 123 NALMFNNELmADVHFVVGppgaSQKVPAHKYVLAVGSSVFGAMFYGDLAE-GESEIHIPDVEPAAFLILLKYMYSDEIEL 201
Cdd:cd18242   13 NSLRKSNTL-CDVTLRVE----GKEFPAHRIVLAACSDYFCAMFTSEMSEkGKSEVELQGLTASTMEILLDFVYTETVHV 87

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 528511250 202 EADTVLATLYAAKKYIVPALAKACVTFLETSLEAKN 237
Cdd:cd18242   88 TVENVQELLPAACLLQLKGVKQACCEFLESQLDPSN 123
BTB_POZ_KLHL28_BTBD5 cd18257
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 119-235 9.61e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349566 [Multi-domain]  Cd Length: 118  Bit Score: 62.17  E-value: 9.61e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 119 LRERNALMFNNELmADVHFVVGppgaSQKVPAHKYVLAVGSSVFGAMFYGDLAEGE-SEIHIPDVEPAAFLILLKYMYSD 197
Cdd:cd18257    6 LQGLNLLRQHHEL-CDVVLRVG----DVKIHAHKVVLASCSPYFKAMFTGNLSEKEnSEVEFQCIDETALQAIVEYAYTG 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 528511250 198 EIELEADTVLATLYAAKKYIVPALAKACVTFLETSLEA 235
Cdd:cd18257   81 TVFISQATVESLLPAANLLQIKLVLKECCDFLESQLDP 118
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 132-231 1.12e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 61.91  E-value: 1.12e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 132 MADVHFVVGppgaSQKVPAHKYVLAVGSSVFGAMFYGDLAEGES-EIHIPDVEPAAFLILLKYMYSDEIELEADTVLATL 210
Cdd:cd18247   19 LCDVTLKVG----DQKFSAHRIVLAATIPYFHAMFTHDMVESKQdEITMQGIEPSALEALINFAYSGRIAIDTSNVQSLL 94

                         90       100
                 ....*....|....*....|.
gi 528511250 211 YAAKKYIVPALAKACVTFLET 231
Cdd:cd18247   95 VGASFLQLQSVKDACCEFLKE 115
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 114-237 1.39e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 62.15  E-value: 1.39e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 114 STHP--TLRERNALMFNNELmADVHFVVGppgaSQKVPAHKYVLAVGSSVFGAMFYGDLAEGES-EIHIPDVEPAAFLIL 190
Cdd:cd18259   13 PSHPqsILDGLQTLRSNPKL-SDVTLLVG----GREFPCHRSVLALCSHYFNAMFTGDFVESISaRVEIKDVDPAVMESL 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 528511250 191 LKYMYSDEIELEADTVLATLYAAKKYIVPALAKACVTFLETSLEAKN 237
Cdd:cd18259   88 IDFAYTGKLTINQGNVEALIRTSNRLQFPTVRKVCSRYLQQQIDATN 134
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 134-238 2.32e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 60.94  E-value: 2.32e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 134 DVHFVVGppgaSQKVPAHKYVLAVGSSVFGAMFYGDLAEGESE-IHIPDVEPAAFLILLKYMYSDEIELEADTVLATLYA 212
Cdd:cd18250   23 DVTLCAG----GREFPCHRTVLAAASSYFRAMFAGELRESRADrVVLHGVSAEILGLLLDFSYTGRVTVTQDNVEALLRA 98

                         90       100
                 ....*....|....*....|....*.
gi 528511250 213 AKKYIVPALAKACVTFLETSLEAKNA 238
Cdd:cd18250   99 ADLFQFPSVKEACCAYLQQRLDVSNC 124
BTB_POZ_KLHL4 cd18336
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 132-237 2.58e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349645 [Multi-domain]  Cd Length: 126  Bit Score: 61.21  E-value: 2.58e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 132 MADVHFVVGppgaSQKVPAHKYVLAVGSSVFGAMFYGDLAEG-ESEIHIPDVEPAAFLILLKYMYSDEIELEADTVLATL 210
Cdd:cd18336   19 LCDVLLIAG----NLKIPAHRLVLSAVSDYFAAMFTNDVREAkQEEIKMEGVDPDALKALVHYAYTGVLELKEDTIESLL 94

                         90       100
                 ....*....|....*....|....*..
gi 528511250 211 YAAKKYIVPALAKACVTFLETSLEAKN 237
Cdd:cd18336   95 AAACLLQLSQVIDVCCNFLMKQLHPSN 121
BTB_POZ_KLHL20_KLEIP cd18249
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 116-237 1.25e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349558 [Multi-domain]  Cd Length: 128  Bit Score: 59.00  E-value: 1.25e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 116 HP--TLRERNALMFNNELmADVHFVVGppgaSQKVPAHKYVLAVGSSVFGAMFYGDLAEG-ESEIHIPDVEPAAFLILLK 192
Cdd:cd18249    6 HPrqTLEAINLLRKHREL-CDVVLVVG----AKKIYAHRVILSACSPYFRAMFTGELAESrQTEVTIRDIDERAMELLID 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 528511250 193 YMYSDEIELEADTVLATLYAAKKYIVPALAKACVTFLETSLEAKN 237
Cdd:cd18249   81 FAYTSQITVEEGNVQTLLPAACLLQLAEIQEVCCEFLKRQLDPSN 125
BTB_POZ_KLHL2_Mayven cd18338
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 122-233 2.01e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349647 [Multi-domain]  Cd Length: 121  Bit Score: 58.54  E-value: 2.01e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 122 RNALMFNNEL-----MADVHFVvgppGASQKVPAHKYVLAVGSSVFGAMFYGDLAEGESE-IHIPDVEPAAFLILLKYMY 195
Cdd:cd18338    6 KKAFKVMNELrsqnlLCDVTIV----AEDVEIAAHRVVLAACSPYFHAMFTGEMSESRAKrVRIKEVDGWTLKMLIDYVY 81

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 528511250 196 SDEIELEADTVLATLYAAKKYIVPALAKACVTFLETSL 233
Cdd:cd18338   82 TAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQL 119
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 145-216 2.50e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 56.91  E-value: 2.50e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 528511250 145 SQKVPAHKYVLAVGSSVFGAMFYGDLAE-GESEIHIPDVEPAAFLILLKYMYSDEIELEADTVLATLYAAKKY 216
Cdd:cd01165    7 GEKFHVNKELLAQSSEYFRALFRGGFREsGQAEINLRDISPEDFRALLEFLYGGKRDLDASNLLELLEAANFL 79
BTB_POZ_KLHL3 cd18339
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 122-233 4.75e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349648 [Multi-domain]  Cd Length: 121  Bit Score: 57.42  E-value: 4.75e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 122 RNALMFNNEL-----MADVHFVvgppGASQKVPAHKYVLAVGSSVFGAMFYGDLAEGESE-IHIPDVEPAAFLILLKYMY 195
Cdd:cd18339    6 KKAFKVMNELrskqlLCDVTIV----AEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKkIEIKDVDGQTLSKLIDYIY 81

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 528511250 196 SDEIELEADTVLATLYAAKKYIVPALAKACVTFLETSL 233
Cdd:cd18339   82 TAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQL 119
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 128-237 6.31e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 56.77  E-value: 6.31e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 128 NNELMADVHFVVGppgaSQKVPAHKYVLAVGSSVFGAMFYGDLAEG-ESEIHIPDVEPAAFLILLKYMYSDEIELEADTV 206
Cdd:cd18253   14 DSRLFTDVIICVE----GREFPCHRAILSACSSYFRAMFCNDHRESrEMLVEINGILAEAMDCFLQYVYTGKVKITTENV 89

                         90       100       110
                 ....*....|....*....|....*....|.
gi 528511250 207 LATLYAAKKYIVPALAKACVTFLETSLEAKN 237
Cdd:cd18253   90 QYLFETSSLFQISPLRDACAKFLEEQLDPCN 120
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 126-237 7.26e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 56.77  E-value: 7.26e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 126 MFNNELMADVHFVVGppgaSQKVPAHKYVLAVGSSVFGAMFYGDLAEG-ESEIHIPDVEPAAFLILLKYMYSDE---IEL 201
Cdd:cd18279   12 LWENSRFTDCCLCVG----GQEFQAHKAILAARSPVFSAMFEHEMEESkKNRVEINDVDPEVFKEMMRFIYTGKapnLDK 87

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 528511250 202 EADTVLAtlyAAKKYIVPALAKACVTFLETSLEAKN 237
Cdd:cd18279   88 MADDLLA---AADKYALERLKVMCEDALCSNLSVEN 120
BTB_POZ_KLHL41_KBTBD10 cd18341
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 145-237 7.51e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349650 [Multi-domain]  Cd Length: 133  Bit Score: 57.16  E-value: 7.51e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 145 SQKVPAHKYVLAVGSSVFGAMFYGDLAEG-ESEIHIPDVEPAAFLILLKYMYSDEIELEADTVLATLYAAKKYIVPALAK 223
Cdd:cd18341   36 DKSLPCHRLILAACSPYFREYFLSEESEEkKKEVVLDNVDPNIMDMILKYLYSAEIDLNDGNVQDIFALASRFQIPSVFT 115

                         90
                 ....*....|....
gi 528511250 224 ACVTFLETSLEAKN 237
Cdd:cd18341  116 VCVTYLQKRLSPAN 129
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 118-242 1.53e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 56.16  E-value: 1.53e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 118 TLRERNALMFNNELMADVHFVVgppgASQKVPAHKYVLAVGSSVFGAMFYGDLAEG-ESEIHIPDVEPAAFLILLKYMYS 196
Cdd:cd18270   12 SLLEQLKFFYEQQLLTDIVLIV----EGTEFPCHKMVLATCSSYFRAMFMSGLSESkQTHVHLRNVDAATLQIIITYAYT 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 528511250 197 DEIELEADTVlATLYAAKKYI-VPALAKACVTFLETSLEAKNaCVLL 242
Cdd:cd18270   88 GNLAINDSTV-EQLYETACFLqVEDVLQRCREYLIKKINAEN-CVRL 132
BTB_POZ_KLHL6 cd18236
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 113-240 1.73e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349545 [Multi-domain]  Cd Length: 129  Bit Score: 56.01  E-value: 1.73e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 113 QSTHPTLRERNALmfnnelmADVHFVVGppgaSQKVPAHKYVLAVGSSVFGAMFYGDLAEG-ESEIHIPDVEPAAFLILL 191
Cdd:cd18236   12 QNGLENLRLENSL-------TDVILCVD----SQEFSCHRVVLAAASNYFRAMFCNDLKEKyEEKIIIKGVDAETMQILL 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 528511250 192 KYMYSDEIELEADTVLATLYAAKKYIVPALAKACVTFLETSLEAKNaCV 240
Cdd:cd18236   81 DYTYTSKVLITKQNVQRVLEAASLFQFLRMVDACASFLTEALHPEN-CV 128
BTB_POZ_KLHL1 cd18335
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 118-237 2.10e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349644 [Multi-domain]  Cd Length: 126  Bit Score: 55.44  E-value: 2.10e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 118 TLRERNALMFNNELmADVHFVVGppgaSQKVPAHKYVLAVGSSVFGAMFYGDLAEG-ESEIHIPDVEPAAFLILLKYMYS 196
Cdd:cd18335    6 TFRKMESYLKQQQL-CDVILIAG----NRKIPAHRLVLSAVSDYFAAMFTSDVCEAkQEEIKMEGIDPNALWDLVQFAYT 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 528511250 197 DEIELEADTVLATLYAAKKYIVPALAKACVTFLETSLEAKN 237
Cdd:cd18335   81 GCLELKEDTIENLLAAACLLQLSQVVEVCCHFLMKLLHPSN 121
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 126-237 2.14e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 55.40  E-value: 2.14e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 126 MFNNELMADVHFVVGppgaSQKVPAHKYVLAVGSSVFGAMFYGDLAEG-ESEIHIPDVEPAAFLILLKYMYSDE---IEL 201
Cdd:cd18343   15 LWENSRFTDCSLFVG----GQEFKAHKSILAARSPVFNAMFEHEMEESkKNRVEINDVDPEVFKEMMRFIYTGKapnLDK 90

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 528511250 202 EADTVLAtlyAAKKYIVPALAKACVTFLETSLEAKN 237
Cdd:cd18343   91 MADNLLA---AADKYALERLKVMCEEALCNNLSVEN 123
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 128-230 3.01e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 54.65  E-value: 3.01e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 128 NNELMADVHFVVGppgaSQKVPAHKYVLAVGSSVFGAMFYGDLAEGESE---IHIPDVEPAAFLILLKYMYSDEIELEAD 204
Cdd:cd18245   10 EEPHLCDATLVVG----GEEIPVQKNVLAAASPYFRAKLNYNPPKDDGStykIELEGISVEVMEEILDYIYTGQIKLSED 85

                         90       100
                 ....*....|....*....|....*.
gi 528511250 205 TVLATLYAAKKYIVPALAKACVTFLE 230
Cdd:cd18245   86 NIQDIVQAADLLLMTDLKDLCCEFLE 111
BTB1_POZ_RhoBTB cd18299
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 126-229 3.41e-09

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349608 [Multi-domain]  Cd Length: 103  Bit Score: 54.14  E-value: 3.41e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 126 MFNNELMADVHFVVGppgASQKVPAHKYVLAVGSSVFgamfyGDLAEGESEIHI-PDVEPAAFLILLKYMYSDEIELEAD 204
Cdd:cd18299    6 LLHSPSCADVVFILQ---GGVRIFAHRIVLAAASSVF-----ADLFLMMTVVTLdSDITPEAFRRVLEFLYTGVLDENED 77

                         90       100
                 ....*....|....*....|....*
gi 528511250 205 TVLATLYAAKKYIVPALAKACVTFL 229
Cdd:cd18299   78 DLKELKDAAELLELFDLVMMCTNVL 102
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 119-237 3.85e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 54.79  E-value: 3.85e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 119 LRERNALMfNNELMADVHFVVGppgaSQKVPAHKYVLAVGSSVFGAMFYGDLAEG-ESEIHIPDVEPAAFLILLKYMYSD 197
Cdd:cd18268   11 LRQLNSLR-QERILTDVILCTG----DKEIPCHRNVLASSSPYFRAMFCNNFRESsQAKVDLKGIDSDVLDQIVDYVYTG 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 528511250 198 EIELEADTVLATLYAAKKYIVPALAKACVTFLETSLEAKN 237
Cdd:cd18268   86 EILITRDNVLPLMEAASMLQYPKLFEACSLYLQDQLTPEN 125
BTB_POZ_KLHL5 cd18337
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 132-237 4.93e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It is abundantly expressed in the ovary, adrenal gland, and thymus. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349646 [Multi-domain]  Cd Length: 130  Bit Score: 54.68  E-value: 4.93e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 132 MADVHFVVGppgaSQKVPAHKYVLAVGSSVFGAMFYGDLAEG-ESEIHIPDVEPAAFLILLKYMYSDEIELEADTVLATL 210
Cdd:cd18337   23 LCDVVLVAG----DRRIPAHRLVLSSVSDYFAAMFTNDVREAkQEEIKMEGVEPNALWALVQYAYTGRLELKEDNIECLL 98

                         90       100
                 ....*....|....*....|....*..
gi 528511250 211 YAAKKYIVPALAKACVTFLETSLEAKN 237
Cdd:cd18337   99 STACLLQLSQVVEACCKFLMKQLHPSN 125
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 133-214 6.79e-09

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 52.94  E-value: 6.79e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 133 ADVHFVVGppgaSQKVPAHKYVLAVGSSVFGAMFYGDLAEGESEIHIPDVEPAAFLILLKYMYSDEIELEADTVLATLYA 212
Cdd:cd18315    2 VDVTLACE----GGSLKAHKLVLAAASPYFAALLKETPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKL 77


                 ..
gi 528511250 213 AK 214
Cdd:cd18315   78 AE 79
BTB_POZ_KBTBD6_7 cd18273
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 125-240 9.58e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349582 [Multi-domain]  Cd Length: 142  Bit Score: 54.06  E-value: 9.58e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 125 LMFNNELMADVHFVV----GPPGASQKVPAHKYVLAVGSSVFGAMFYGDLAEGESE-IHIPDVEPAAFLILLKYMYSDEI 199
Cdd:cd18273   19 SFYDARLLTDVTIEVngpgSGPGSGRLFPCNRNVLAAASPYFKSMFTGGLYESKQEtVTIHDVDSESMALIIDYCYTGRV 98

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 528511250 200 ELEADTVlATLYAAKKYI-VPALAKACVTFLETSLEAKNaCV 240
Cdd:cd18273   99 TLSEANV-QRLYAAANMLqLEYVREACASFLARRLDLSN-CV 138
BTB_POZ_ZBTB28_BCL6B cd18332
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 130-230 1.08e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349641 [Multi-domain]  Cd Length: 114  Bit Score: 53.32  E-value: 1.08e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 130 ELMADVHFVVGppgaSQKVPAHKYVLAVGSSVFGAMFYGDLAEGESEIHIPD-VEPAAFLILLKYMYSDEIELEADTVLA 208
Cdd:cd18332   17 DILTDVTLLVG----GTPLRAHKAVLIACSGFFYSIFSGRVGEGVSVLTLPSgLEARGFQLLLDFMYTSRLPLTPRTVPA 92

                         90       100
                 ....*....|....*....|..
gi 528511250 209 TLYAAKKYIVPALAKACVTFLE 230
Cdd:cd18332   93 VLAAATYLQMEHVVETCRRFIQ 114
BTB_POZ_ARIA_plant cd18352
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 128-225 1.16e-08

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349661 [Multi-domain]  Cd Length: 116  Bit Score: 53.25  E-value: 1.16e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 128 NNELMADVHFVVgppgASQKVPAHKYVLAVGSSVFGAMFYGDLAEGE-SEIHIPDVEPAAFLILLKYMYSDEIELEADTV 206
Cdd:cd18352    9 NNATLSDVTFLV----EGRRFYAHRIALLASSDAFRAMFDGGYREKEaRDIEIPNIRWEVFELMMRFIYTGSVDITNDIA 84

                         90
                 ....*....|....*....
gi 528511250 207 LATLYAAKKYIVPALAKAC 225
Cdd:cd18352   85 KDLLRAADQYLLEGLKRLC 103
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 119-238 1.55e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 52.93  E-value: 1.55e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 119 LRERNALMFNNELMADVHFVVGppgaSQKVPAHKYVLAVGSSVFGAMFYGDLAEGE-SEIHIPDVEPAAFLILLKYMYSD 197
Cdd:cd18345    5 LSDDLGLLFERSAFSDVTLCVG----GREFQAHKAILAARSPVFNAMFEHEMEERKqNRVEITDVDHEVMREMLRFIYTG 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 528511250 198 E---IELEADTVLAtlyAAKKYIVPALAKACVTFLETSLEAKNA 238
Cdd:cd18345   81 KapnLDKMADDLLA---AADKYALERLKVMCEEALCSNLSVENV 121
BTB_POZ_KLHL22 cd18251
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 148-237 3.79e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349560 [Multi-domain]  Cd Length: 125  Bit Score: 52.13  E-value: 3.79e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 148 VPAHKYVLAVGSSVFGAMFYGDLAEGE-SEIHIPDVEPAAFLILLKYMYSDEIELEADTVLATLYAAKKYIVPALAKACV 226
Cdd:cd18251   35 IEAHRILLAASCDYFRGMFAGGLREMQqTEVLIHGVSYNAMCKILDFIYTSELELSLDNVQETLTAACQLQIPEVIGFCC 114

                         90
                 ....*....|.
gi 528511250 227 TFLETSLEAKN 237
Cdd:cd18251  115 DFLMSWVDNEN 125
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 151-238 3.90e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 51.91  E-value: 3.90e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 151 HKYVLAVGSSVFGAMFYGDLAEG-ESEIHIPDVEPAAFLILLKYMYSDEIELEADTVLATLYAAKKYIVPALAKACVTFL 229
Cdd:cd18274   38 HRNVLAAISPYFRSMFTSGLTEStQKEVRIVGVEAESMHLVLDYAYTSRVTLTEANVQALFTAASIFQIPSLQDQCAQFM 117


                 ....*....
gi 528511250 230 ETSLEAKNA 238
Cdd:cd18274  118 ISRLDPQNS 126
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 149-239 6.45e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 51.72  E-value: 6.45e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 149 PAHKYVLAVGSSVFGAMFYGDLAE-GESEIHIPDVEPAAFLILLKYMYSDEIELEADTVLATLYAAKKYIVPALAKACVT 227
Cdd:cd18264   41 PAHRSLLACSSDYFRALFKDYTQEsKARVIHLPVVSAAGLQRVLDFIYTSWLSLSLDTLEDTLEAASYLQVTEAIGLCSQ 120

                         90
                 ....*....|..
gi 528511250 228 FLETSLEAKNAC 239
Cdd:cd18264  121 YLINNLAPENCC 132
BTB2_POZ_RHOBTB3 cd18360
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 125-234 6.88e-08

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3); RhoBTB3 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB3 is a Golgi-associated Rho-related ATPase that regulates the S/G2 transition of the cell cycle by targeting cyclin E for ubiquitylation. It is involved in vesicle trafficking and in targeting proteins for degradation in the proteasome. It binds directly to Rab9 GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi network. It also promotes proteasomal degradation of Hypoxia-inducible factor alpha (HIFalpha) through facilitating hydroxylation and suppresses the Warburg effect. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349669 [Multi-domain]  Cd Length: 110  Bit Score: 50.62  E-value: 6.88e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 125 LMFNNELMADVHFVVgppgASQKVPAHKYVLAVGSSVFGAMFYGDLAEGESE-IHIPDVEPAAFLILLKYMYSDEI---- 199
Cdd:cd18360    3 LFFNSPLLADVVFKI----QGTTVPAHRAVLVARCEVMAAMFNGNYAEAKSFlVPIYGVSKDTFLSFLEYLYTDSCcpas 78

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 528511250 200 ELEAdtvLATLYAAKKYIVPALAKACVTFLETSLE 234
Cdd:cd18360   79 ILQA---MALLICAEMYQVSRLQHICELYIITQLQ 110
BTB_POZ_KLHL15 cd18244
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 126-229 8.03e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349553 [Multi-domain]  Cd Length: 137  Bit Score: 51.50  E-value: 8.03e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 126 MFNNELMADVHFVVgppgASQKVPAHKYVLAVGSSVFGAMFYGDLAE-GESEIHIPDVEPAAFLILLKYMYSDEIELEAD 204
Cdd:cd18244   24 LYEEGLLLDVTLVI----EDHQFQAHKALLATQSDYFRIMFTADMRErDQDKIHLKGLTATGFSHVLQFMYYGTIELSML 99

                         90       100
                 ....*....|....*....|....*
gi 528511250 205 TVLATLYAAKKYIVPALAKACVTFL 229
Cdd:cd18244  100 TVHEILQAAMYVQLTEVVKFCCSFL 124
BTB_POZ_KLHL37_ENC1 cd18267
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 125-237 1.30e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349576 [Multi-domain]  Cd Length: 147  Bit Score: 51.14  E-value: 1.30e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 125 LMFNNELMADVHFVVGppgaSQKVPAHKYVLAVGSSVFGAMFYGDLAEGE-SEIHIPD-VEPAAFLILLKYMYSDEIELE 202
Cdd:cd18267   33 LLRQQRLFTDVLLHAG----NRSFPCHRAVLAACSRYFEAMFSGGLKESQdSEVNFHDsIHPEVLELLLDYAYSSRVIIN 108

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 528511250 203 ADTVLATLYAAKKYIVPALAKACVTFLETSLEAKN 237
Cdd:cd18267  109 EENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTN 143
BTB1_POZ_LZTR1 cd18308
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 114-199 1.34e-07

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349617 [Multi-domain]  Cd Length: 156  Bit Score: 51.22  E-value: 1.34e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 114 STHP--TLRERNALMFNNELMADVHFVVGPPGasQKVPAHKYVLAVGSS-------------------VFGAMFYGDLAE 172
Cdd:cd18308    3 SSYPkcTLHDDFGRLLESRQFCDVEFIVGEEE--ERIPAHIAFVAARSKwlrnkilqarerqkqkaeqEVEDEGSEADSS 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 528511250 173 GES-------EIHIPDVEPAAFLILLKYMYSDEI 199
Cdd:cd18308   81 SASkndspmlEVRLPEADPEAFELILSFIYTDKI 114
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 134-197 2.32e-07

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 48.82  E-value: 2.32e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 528511250 134 DVHFVVGppgaSQKVPAHKYVLAVGSSVFGAMFYGDLAEGES-----EIHIPDVEPAAFLILLKYMYSD 197
Cdd:cd18301   20 DVVFQVG----GKTFPAHKFILASRSDYFRKLFLSSLLTSEDavgcdVVHIEKVPPEIFEQLLQFIYTD 84
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 119-237 3.52e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 48.93  E-value: 3.52e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 119 LRERNALMFNNELMaDVHFVVGppgaSQKVPAHKYVLAVGSSVFGAMFYGDLAEG-ESEIHIPDVEPAAFLILLKYMYSD 197
Cdd:cd18255    6 LQGLNALRAKGQLL-DVTLIAD----GQRFQAHKVVLASCSDYFRAMFTGGMRESsQDEIELKGVSAKGLKHILDFAYTS 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 528511250 198 EIELEADTVLATLYAAKKYIVPALAKACVTFLETSLEAKN 237
Cdd:cd18255   81 ELTLDLDCIQDVLGAAVHLQMLPVVELCEEFLKSAMSVEN 120
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 120-237 3.54e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 49.45  E-value: 3.54e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 120 RERNALMFNNELMADvhfvvgppgasQKVPAHKYVLAVGSSVFGAMFYGDLAE-GESEIHIPDVEPAAFLILLKYMYSDE 198
Cdd:cd18271   19 REQNAFFDFNIIVKD-----------ETIPCHRCVLAACSDFFRAMFEVNMKErDDGSVTISNLSPKAVKAFLDYAYTGK 87

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 528511250 199 IELEADTVLATLYAAKKYIVPALAKACVTFLETSLEAKN 237
Cdd:cd18271   88 AEITDDNVEMFFQMSSFLQVSLLSKACSDFLIKSIDLTN 126
BTB_POZ_KBTBD4 cd18272
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 125-237 4.23e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349581 [Multi-domain]  Cd Length: 140  Bit Score: 49.51  E-value: 4.23e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 125 LMFNNELMADVHFVVgppgASQKVPAHKYVLAVGSSVFGAMFYGDLAEGESE-IHIPDVEPAAFLILLKYMYSDEIELEA 203
Cdd:cd18272   25 LCLEDGLFADVTISV----EGKEFQLHRLVLSAQSCFFRSMFTSNLKEARNRvIELKDVSESVFQLLVDYIYHGTVKLRV 100

                         90       100       110
                 ....*....|....*....|....*....|....
gi 528511250 204 DTVLATLYAAKKYIVPALAKACVTFLETSLEAKN 237
Cdd:cd18272  101 EELQETYEVADMYQLTALFEECSRFLARTVQVRN 134
BACK_BTBD9 cd14822
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); ...
 233-342 4.35e-07

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation.


Pssm-ID: 350518 [Multi-domain]  Cd Length: 101  Bit Score: 48.38  E-value: 4.35e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 233 LEAKNACVLLSQSRLFEEPELTLRCWEVIDAQAELALHSEGFCEIDLQTLEIILKRETLNTREAVVFQAALDWAVAEckr 312
Cdd:cd14822    1 LNIRNVCLIYDVASLYSLDDLCQTCCQFMDRNAQEVLSSEGFLTLSKSALKELLSRDSFCAPEVDIFNAVRRWCEHN--- 77

                         90       100       110
                 ....*....|....*....|....*....|
gi 528511250 313 qglgPTARNKRAVLgkaLYLVRIPTMTLEE 342
Cdd:cd14822   78 ----PDSKEDAKEI---LEAVRLPLMSLTE 100
BTB_POZ_KBTBD12 cd18276
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 118-213 5.65e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349585 [Multi-domain]  Cd Length: 127  Bit Score: 48.65  E-value: 5.65e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 118 TLRERNALMFNNELMADVHFVvgppGASQKVPAHKYVLAVGSSVFGAMFYGDLAE-GESEIHIPDVEPAAFLILLKYMYS 196
Cdd:cd18276    7 TLLDQLNRMKELAELTDVVLV----AEGEKFPCHRLVLAAFSPYFKAMFTCGLMEcSQREVVLHDITAESVSIILNYMYS 82

                         90
                 ....*....|....*..
gi 528511250 197 DEIELEADTVLATLYAA 213
Cdd:cd18276   83 SDLHLTNSNVQGVATAA 99
BTB_POZ_SPOP cd18342
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 144-238 5.72e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349651 [Multi-domain]  Cd Length: 125  Bit Score: 48.56  E-value: 5.72e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 144 ASQKVPAHKYVLAVGSSVFGAMFYGDLAEG-ESEIHIPDVEPAAFLILLKYMYSDE---IELEADTVLAtlyAAKKYIVP 219
Cdd:cd18342   30 AGQEFQAHKAILAARSPVFSAMFEHEMEESkKNRVEINDVEPEVFKEMMCFIYTGKapnLDKMADDLLA---AADKYALE 106

                         90
                 ....*....|....*....
gi 528511250 220 ALAKACVTFLETSLEAKNA 238
Cdd:cd18342  107 RLKVMCEDALCSNLSVENA 125
BTB_POZ_KLHL23 cd18252
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 151-237 9.03e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349561 [Multi-domain]  Cd Length: 127  Bit Score: 47.90  E-value: 9.03e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 151 HKYVLAVGSSVFGAMFYGDLAE-GESEIHIPDVEPAAFLILLKYMYSDEIELEADTVLATLYAAKKYIVPALAKACVTFL 229
Cdd:cd18252   37 HKAALAACSSYFKVMFTADMKEkSNNVIKLSGIDHDILEALVNYVYTSQICITERNVQSLLEAADLLQFISVKKACEQFL 116


                 ....*...
gi 528511250 230 ETSLEAKN 237
Cdd:cd18252  117 VRHLDIDN 124
BTB_POZ_KLHL17_actinfilin cd18246
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 144-234 1.07e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349555 [Multi-domain]  Cd Length: 139  Bit Score: 48.10  E-value: 1.07e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 144 ASQKVPAHKYVLAVGSSVFGAMFYGDLAEG-ESEIHIPDVEPAAFLILLKYMYSDEIELEADTVLATLYAAKKYIVPALA 222
Cdd:cd18246   47 GTKEIKAHKVVLASCSPYFHAMFTNEMSESrQTHVTLHDIDPQALEQLVQYAYTAEIVVGEGNVQTLLPAASLLQLNGVR 126

                         90
                 ....*....|..
gi 528511250 223 KACVTFLETSLE 234
Cdd:cd18246  127 DACCKFLLSQLD 138
BTB_POZ_RCBTB1_2 cd18298
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 127-230 1.15e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349607 [Multi-domain]  Cd Length: 108  Bit Score: 47.25  E-value: 1.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 127 FNNELMADVHFVVGppgaSQKVPAHKYVLAVGSSVFGAMFYGDLAEGESE-IHIPDVEPAAFLILLKYMYSDEIELEADT 205
Cdd:cd18298    7 FNDPRTSDLKFRVD----GKYIYVHKAILKIRCEYFRSMFQSHWNEDDKNvIEIDQYSYPVYYAFLRYLYTDQVDLPPED 82

                         90       100
                 ....*....|....*....|....*
gi 528511250 206 VLATLYAAKKYIVPALAKACVTFLE 230
Cdd:cd18298   83 AIGLLDLANSYCEERLKKLCEDIIK 107
BTB1_POZ_ABTB1_BPOZ1 cd18295
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 133-206 1.81e-06

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349604 [Multi-domain]  Cd Length: 119  Bit Score: 46.86  E-value: 1.81e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 528511250 133 ADVHFVVgppgASQKVPAHKYVLAVGSSVFGAMFYGDLaEGESEIHI--PDVEPAAFLILLKYMYSDEIELEADTV 206
Cdd:cd18295   20 SDVTFNV----HGESFPAHRCILSARSPYFAEMFETKW-KDKREINLkhPLVNPDAFRALLQYLYTGRLEIHVDDV 90
BTB_POZ_ARMC5 cd18191
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 133-195 2.82e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in armadillo repeat-containing protein 5 (ARMC5); ARMC5 plays a role in steroidogenesis, and modulates the expression and cortisol production of steroidogenic enzymes. It negatively regulates adrenal cells survival. It contains armadillo (ARM) repeats and a BTB domain, which is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349500 [Multi-domain]  Cd Length: 100  Bit Score: 45.96  E-value: 2.82e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 528511250 133 ADVHFVVGppgASQKVPAHKYVLAVGSSVFGAMFYGDLAEGE-SEIHIPDVEPAAFLILLKYMY 195
Cdd:cd18191    2 HDLRFLLD---GGTQLPASRAALTGASEVFRAMLEGGFAEAQqDLVPLRQVPSGAFLPVLHYLH 62
BTB_POZ_ZBTB27-like cd18215
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 119-228 2.84e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349524 [Multi-domain]  Cd Length: 113  Bit Score: 46.40  E-value: 2.84e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 119 LRERNalmfnneLMADVHFVVGppgaSQKVPAHKYVLAVGSSVFGAMFYGDLAEGESEIHIP-DVEPAAFLILLKYMYSD 197
Cdd:cd18215   13 LRSRD-------ILTDVVLVVG----REQFRAHKTVLMACSGLFYSIFTDQLKNNVSVINLDpEIEPEGFRILLDFMYTS 81

                         90       100       110
                 ....*....|....*....|....*....|.
gi 528511250 198 EIELEADTVLATLYAAKKYIVPALAKACVTF 228
Cdd:cd18215   82 RLNLREGNIMAVMATAMYLQMEHVVDTCRKF 112
BTB_POZ_TDPOZ cd18344
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 126-238 7.10e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349653 [Multi-domain]  Cd Length: 128  Bit Score: 45.72  E-value: 7.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 126 MFNNELMADVHFVVgppgASQKVPAHKYVLAVGSSVFGAMFYGDLAEG-ESEIHIPDVEPAAFLILLKYMYSDEIELEAD 204
Cdd:cd18344   17 LWENSLFTDCCLLV----AGHEFRAHKAILAARSPVFRAMFEHEMEERlKNPIEIHDLDPQVFKEMMGFIYTGKAPHLHS 92

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 528511250 205 TVLAT--LYAAKKYIVPALAKACVTFLETSLEAKNA 238
Cdd:cd18344   93 HSMACdvLAAADKYGLEGLKVLCEDALCRNLSVENA 128
BTB_POZ_ZBTB44 cd18228
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 146-234 1.20e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349537 [Multi-domain]  Cd Length: 126  Bit Score: 44.85  E-value: 1.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 146 QKVPAHKYVLAVGSSVFGAMFYGDLAE-----GESEIHIPD---VEPAAFLILLKYMYSDEIELEADTVLATLYAAKKYI 217
Cdd:cd18228   29 KIFRAHKVVLAACSDFFRSKLVGQASPrlvlvSPAGKCVLDlhhVTVTGFAPLLEYAYTSTLSINTENIIDVLAAASYMQ 108

                         90
                 ....*....|....*..
gi 528511250 218 VPALAKACVTFLETSLE 234
Cdd:cd18228  109 MFNVANTCSEFMKSSIL 125
BTB_POZ_ZBTB3-like cd18194
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 119-217 1.34e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349503 [Multi-domain]  Cd Length: 128  Bit Score: 44.81  E-value: 1.34e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 119 LRERNALMFnnelMADVHFVVGppgaSQKVPAHKYVLAvGSSVFGAMFYGDLAEGESEIHIPD--VEPAAFLILLKYMYS 196
Cdd:cd18194   14 LREQRSQGF----LCDCTVLVG----SAQFPAHRAVLA-SCSMYFHLFYRDRLDKRDLVRLNSdiVTAPAFGLLLDFMYE 84

                         90       100
                 ....*....|....*....|.
gi 528511250 197 DEIELEaDTVLATLYAAKKYI 217
Cdd:cd18194   85 GRLALR-DLPVEDVLAAASYL 104
BTB_POZ_KLHL9_13 cd18239
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 129-237 2.19e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349548 [Multi-domain]  Cd Length: 128  Bit Score: 44.03  E-value: 2.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 129 NELMADVHFVvgPPGASQKVPAHKYVLAVGSSVFGAMFYGDLAEGE-SEIHIPDVEPAAFLILLKYMYSDEIELEADTVL 207
Cdd:cd18239   20 EGLLCDVTLV--PGDGDETFPVHRAMMASASDYFKAMFTGGMKEQElMCIKLHGVSKIGLKNIIDFIYTAKLSLNMDNLQ 97

                         90       100       110
                 ....*....|....*....|....*....|
gi 528511250 208 ATLYAAKKYIVPALAKACVTFLETSLEAKN 237
Cdd:cd18239   98 DTLEAASFLQILPVLDFCKVLLISGVTLEN 127
BACK_GPRS_like cd18507
BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster serine-enriched ...
 234-306 2.48e-05

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster serine-enriched protein (GPRS) and similar proteins; The family includes uncharacterized Drosophila melanogaster serine-enriched protein (GPRS) and similar proteins.


Pssm-ID: 350582  Cd Length: 80  Bit Score: 42.50  E-value: 2.48e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 528511250 234 EAKNACVLLSQSRLFEEP----ELTLRCWEVIDAQAELALHSEGFCEIDLQTLEIILKRETLNTREAVVFQAALDWA 306
Cdd:cd18507    1 NVDTVCALLASAERYDQYkctkTLVQKVLEFVDKHGTDVLNLPEFLLLPEHVVRLILSRDSLGADEMTKFQAALAWS 77
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 251-345 4.91e-05

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 42.53  E-value: 4.91e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250  251 PELTLRCWEVIDAQAELALHSEGFCEIDLQTLEIILKRETLNT-REAVVFQAALDWAVAECKRqglgptarnKRAVLGKA 329
Cdd:pfam07707  14 TELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVpSEEEVFEAVIRWVKHDVER---------RKKHLPEL 84

                          90
                  ....*....|....*.
gi 528511250  330 LYLVRIPTMTLEEFAN 345
Cdd:pfam07707  85 LSAVRLPLLSPQYLLN 100
BTB_POZ_ABTB2_BPOZ2 cd18350
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 128-238 5.30e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2); ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins with various functions ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, with implications for Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homolog (PTEN). It contains an ankyrin repeat, BTB/POZ, and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349659 [Multi-domain]  Cd Length: 134  Bit Score: 43.30  E-value: 5.30e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 128 NNELMADVHFVVgppgASQKVPAHKYVLAVGSSVFGAMFY---GDLAEGESEIHIPDVEPAAFLILLKYMY---SDEIEL 201
Cdd:cd18350   20 NNKEMSDVTFLV----EGKLFYAHKVLLVTASNRFKSLLTnksEQESQGSKTIEISDIKYHIFQMLMQYLYyggTESMEI 95

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 528511250 202 EADTVLATLYAAKKYIVPALAKACVTFLETSLEAKNA 238
Cdd:cd18350   96 PIADVLELLSAASLFQLDALQRHCEILCSQTINLENA 132
BTB_POZ_ZBTB27_BCL6 cd18331
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 130-229 5.52e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349640 [Multi-domain]  Cd Length: 118  Bit Score: 42.54  E-value: 5.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 130 ELMADVHFVVGppgaSQKVPAHKYVLAVGSSVFGAMFYGDLAEGESEIHI-PDVEPAAFLILLKYMYSDEIELEADTVLA 208
Cdd:cd18331   22 DILTDVVIVVS----REQFRAHKTVLMACSGLFYSIFTDQLKCNLSVINLdPEINPEGFNILLDFMYTSRLNLREGNIMA 97

                         90       100
                 ....*....|....*....|.
gi 528511250 209 TLYAAKKYIVPALAKACVTFL 229
Cdd:cd18331   98 VMATAMYLQMEHVVDTCRKFI 118
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 145-237 6.16e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 42.69  E-value: 6.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 145 SQKVPAHKYVLAVGSSVFGAMFYGDLAEG-ESEIHIPD-VEPAAFLILLKYMYSDEIELEADTVLATLYAAKKYIVPALA 222
Cdd:cd18254   31 NRSFPCHRAVLAACSRYFEAMFSNGLRESlDSTVNFHDsLHPEVLELLLDFAYSSRIIINEENAESLLEAGDMLQFHDVR 110

                         90
                 ....*....|....*
gi 528511250 223 KACVTFLETSLEAKN 237
Cdd:cd18254  111 DAAAEFLEKNLYPSN 125
BTB_POZ_ZBTB23_GZF1 cd18211
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 132-225 8.17e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349520 [Multi-domain]  Cd Length: 128  Bit Score: 42.53  E-value: 8.17e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 132 MADVHFVVGPPGASQKVPAHKYVLAVGSSVFGAMFYGDLAEG--ESEIHIPDVEPAAFLILLKYMYSDEIELEADTVLAT 209
Cdd:cd18211   25 LCDVTVQVEHQGSKEEFSAHKAVLAASSKYFKEVFLNEKISDgkNTNVMLNEIYTADFASFLEFVYTAKVEVEEDRVQRM 104

                         90
                 ....*....|....*.
gi 528511250 210 LYAAKKYIVPALAKAC 225
Cdd:cd18211  105 LEIAEKLKCLDLSETC 120
PHA03098 PHA03098
kelch-like protein; Provisional
 147-240 8.72e-05

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 45.14  E-value: 8.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 147 KVPAHKYVLAVGSSVFGAMFYGDLAEGESEIHIpDVEpaAFLILLKYMYSDEIELEADTVLATLYAAKKYIVPALAKACV 226
Cdd:PHA03098  22 IIKVHKIILSSSSEYFKKMFKNNFKENEINLNI-DYD--SFNEVIKYIYTGKINITSNNVKDILSIANYLIIDFLINLCI 98

                         90
                 ....*....|....
gi 528511250 227 TFLETSLEAKNaCV 240
Cdd:PHA03098  99 NYIIKIIDDNN-CI 111
BTB_POZ_ZBTB7A cd18326
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 128-230 1.07e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349635 [Multi-domain]  Cd Length: 120  Bit Score: 41.84  E-value: 1.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 128 NNELMADVHFVVgppgASQKVPAHKYVLAVGSSVFGAMFYGDLAEGESEIHIPD-VEPAAFLILLKYMYSDEIELEADTV 206
Cdd:cd18326   21 TQGLLCDVVILV----EGREFPTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDfVSAEALTALLDFAYTATLTVSTSNV 96

                         90       100
                 ....*....|....*....|....
gi 528511250 207 LATLYAAKKYIVPALAKACVTFLE 230
Cdd:cd18326   97 GDILSAARLLEIPAVSHVCADLLD 120
BTB_POZ_ZBTB21_ZNF295 cd18209
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 132-208 1.19e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349518 [Multi-domain]  Cd Length: 112  Bit Score: 41.78  E-value: 1.19e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 528511250 132 MADVHFVVGppgaSQKVPAHKYVLAVGSSVFGAMFYGDLAEGESEIHIPDVEPAAFLILLKYMYSDEIELEADTVLA 208
Cdd:cd18209   18 LCDVLLIVG----DQKFRAHKNVLAASSEYFQSLFTEKENESQSVFQLDFCEPDAFENVLNYIYSSSLFVEKSSLAA 90
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 235-288 1.28e-04

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 39.95  E-value: 1.28e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 528511250 235 AKNACVLLSQSRLFEEPELTLRCWEVIDAQAELALHSEGFCEIDLQTLEIILKR 288
Cdd:cd14733    2 PENCLGILELADLYNLEELKEKALKFILENFEEVSKSEEFLELSVELLLELLSS 55
BTB_POZ_KLHL31_KBTBD1 cd18260
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 117-237 1.72e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349569 [Multi-domain]  Cd Length: 120  Bit Score: 41.34  E-value: 1.72e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 117 PTLRERNALMFNNELMADVhfVVGPPGASQKVpaHKYVLAVGSSVFGAMFYGDLAEGESEIHipDVEPAAFLILLKYMYS 196
Cdd:cd18260    3 ANLLEGLNRMRQERFLCDL--TIATKTKSFDV--HKVVMASCSEYFRNILKKDPSLQRVELN--DISPLGLATVITYAYT 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 528511250 197 DEIELEADTVLATLYAAKKYIVPALAKACVTFLETSLEAKN 237
Cdd:cd18260   77 GKLTLSLYTIGSTISAASYLQIHALVKMCCDFLMQEMNVEN 117
BTB_POZ_KLHL32 cd18261
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 128-237 1.95e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349570 [Multi-domain]  Cd Length: 133  Bit Score: 41.49  E-value: 1.95e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 128 NNELMADVHFVVGppgaSQKVPAHKYVLAVGSSVFGAMFYGDLAEGES-EIHIPDVEPAAFLILLKYMYSDEIELEADTV 206
Cdd:cd18261   24 NDGILCDITLVAE----EQKFHAHKAVLAACSDYFRAMFSLCMVESEAdEVNLHGVTSLGLKQALDFAYTGQILLEPGVI 99

                         90       100       110
                 ....*....|....*....|....*....|.
gi 528511250 207 LATLYAAKKYIVPALAKACVTFLETSLEAKN 237
Cdd:cd18261  100 QDVLAAGSHLQLLELLSLCSHYLIQELNSFN 130
BTB_POZ_ZBTB7 cd18198
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 131-230 2.48e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349507 [Multi-domain]  Cd Length: 120  Bit Score: 41.01  E-value: 2.48e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 131 LMADVHFVVgppgASQKVPAHKYVLAVGSSVFGAMFY-GDLAEGESEIHIPDVEPAAFLILLKYMYSDEIELEADTVLAT 209
Cdd:cd18198   24 LLCDVVILV----QGREYRTHRSVLAACSQYFKKLFTsGAVVDQQNVYEIDFVSPEALTALLEFAYTATLTVSTANVGDI 99

                         90       100
                 ....*....|....*....|.
gi 528511250 210 LYAAKKYIVPALAKACVTFLE 230
Cdd:cd18198  100 LSAARLLEIPCVSHVCAEILD 120
BTB_POZ_ZBTB7C_ZBTB36 cd18328
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 129-230 3.79e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349637 [Multi-domain]  Cd Length: 120  Bit Score: 40.25  E-value: 3.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 129 NELMADVHFVVgppgASQKVPAHKYVLAVGSSVFGAMFY-GDLAEGESEIHIPDVEPAAFLILLKYMYSDEIELEADTVL 207
Cdd:cd18328   22 DGLLCDVVLIV----QDQEYRTHRSVLAACSKYFKKLFTaGTLADQPYVYEIDFVTPEALSAILEFAYTSTLTITTSNVK 97

                         90       100
                 ....*....|....*....|...
gi 528511250 208 ATLYAAKKYIVPALAKACVTFLE 230
Cdd:cd18328   98 HILNAAQMLEIQCIINVCLEIMD 120
BTB_POZ_KLHL11 cd18241
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 131-237 4.14e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349550 [Multi-domain]  Cd Length: 135  Bit Score: 40.61  E-value: 4.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 131 LMADVHFVVGPPGAsQKVPAHKYVLAVGSSVFGAMFYGDLAEGESE-------IHIPDVEPAAFLILLKYMYSDEIELEA 203
Cdd:cd18241   22 LFCDITLAFGGAGG-REFRAHRSVLAAATEYFTPLLSGQFSESRSGrvemrkwSSEPGPDPDTVEAVIQYMYTGRIRVST 100

                         90       100       110
                 ....*....|....*....|....*....|....
gi 528511250 204 DTVLATLYAAKKYIVPALAKACVTFLETSLEAKN 237
Cdd:cd18241  101 GNVHEVLELADRFLLIRLKEFCGEFLKKKLNLSN 134
BTB2_POZ_KLHL33 cd18263
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 150-233 4.55e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349572 [Multi-domain]  Cd Length: 118  Bit Score: 40.18  E-value: 4.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 150 AHKYVLAVGSSVFGAMFYGDLAEG-ESEIHIPDVEPAAFLILLKYMYSDEIELEADTVLATLYAAKKY-IVPALAkACVT 227
Cdd:cd18263   27 VHRVILAAGSDYFRAMFTSGMKEStQSVVQLPTIPAKDLRLLISFAYSGILHLSWENLFEATCTALQLqISGALA-LCLD 105


                 ....*.
gi 528511250 228 FLETSL 233
Cdd:cd18263  106 FLQREI 111
BTB_POZ_KLHL36 cd18266
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 131-237 6.10e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349575 [Multi-domain]  Cd Length: 135  Bit Score: 40.26  E-value: 6.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 131 LMADVHFVVGppgaSQKVPAHKYVLAVGSSVFGAMFYGDLAEG-ESEIHIPDVEPAAFLILLKYMYSDEIELEADTVLAT 209
Cdd:cd18266   24 LFCDVVLVAD----EQRVPAHRNLLAVCSDYFNSMFTIGMREAhQKEVELVGASYIGLKAVIDFLYSSELPLDGGNIDYV 99

                         90       100
                 ....*....|....*....|....*...
gi 528511250 210 LYAAKKYIVPALAKACVTFLETSLEAKN 237
Cdd:cd18266  100 LETAHLLQIWKVVDFCCEYLENEVSEEN 127
BTB_POZ_GCL cd18305
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 146-225 6.64e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349614 [Multi-domain]  Cd Length: 115  Bit Score: 39.57  E-value: 6.64e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 146 QKVPAHKYVLaVGSSVFGAMFYGDLAEGES---EIHIPD--VEPAAFLILLKYMYSDEIELEADTVLATLYAAKKYIVPA 220
Cdd:cd18305   25 REWKLHKIYL-CQSGYFASMFSGSWKESKEtviNLEIPDdnITVEALNVVFGSLYRDEIEIKPSRVVSILAAATLLQLDG 103


                 ....*
gi 528511250 221 LAKAC 225
Cdd:cd18305  104 LIQQC 108
BTB_POZ_ZBTB49 cd18233
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 150-230 6.71e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349542 [Multi-domain]  Cd Length: 112  Bit Score: 39.49  E-value: 6.71e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 150 AHKYVLAVGSSVFGAMFYGDLAEGESEIHIPDVEPAAFLILLKYMYSDEIELEADTVLATLYAAKKYIVPALAKACVTFL 229
Cdd:cd18233   32 AHKNVLAAFSQYFRSLFQNSSSQKNDVFHLDIKNVGGIGQILDFMYTSHLDLNQDNVQVMLDIAQCLQVQNVLNMCYTFL 111


                 .
gi 528511250 230 E 230
Cdd:cd18233  112 K 112
BTB_POZ_BTBD14A_NAC2 cd18289
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 131-213 7.10e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349598 [Multi-domain]  Cd Length: 131  Bit Score: 40.01  E-value: 7.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 131 LMADVHFVVgppgASQKVPAHKYVLAVGSSVFGAMFYGDlaeGESEIHIP-DVEPAAFLILLKYMYSDEIELEADTVLAT 209
Cdd:cd18289   28 LYCDVSIVV----KGQAFKAHRAVLAASSLYFRDLFSGN---SKSAFELPaTVPPACFQQILSFCYTGKLTMAASEQLVV 100


                 ....
gi 528511250 210 LYAA 213
Cdd:cd18289  101 MYTA 104
BTB_POZ_KBTBD11 cd18275
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 146-242 7.40e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349584 [Multi-domain]  Cd Length: 104  Bit Score: 39.01  E-value: 7.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 146 QKVPAHKYVLAVGSSVFGAMFYGDLaegeseIHIPDVEPAAFLILLKYMYSDEIELEADTVLATLYAAKKYIVPALAKAC 225
Cdd:cd18275   14 QRIRAHKSVLAAKSDYFRARLSRDI------LKVKGLSYATLRLLVDYVYSGRMAVSKDNVVEVVAGARFLQMPCAAQCA 87

                         90
                 ....*....|....*..
gi 528511250 226 VTFLETSLEAKNACVLL 242
Cdd:cd18275   88 VDAVRAQLCLGNCYEVL 104
BTB_POZ_ZBTB46 cd18230
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 150-234 7.80e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349539 [Multi-domain]  Cd Length: 125  Bit Score: 39.66  E-value: 7.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 150 AHKYVLaVGSSVFGAMFYGDLAEGESE---IHIPDVEPAAFLILLKYMYSDEIELEADTVLATLYAAKKYIVPALAKACV 226
Cdd:cd18230   35 AHKNVL-LGSSRYFKTLYCQVQKTSDQatvTHLDIVTAQGFKAIIDFMYSAHLALTSKNVIEVMSAASYLQMTDIVQACH 113


                 ....*...
gi 528511250 227 TFLETSLE 234
Cdd:cd18230  114 NFIKAALD 121
BTB_POZ_RCBTB1_CLLD7 cd18353
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 127-225 7.92e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1); RCBTB1 is also called chronic lymphocytic leukemia deletion region gene 7 protein (CLLD7), CLL deletion region gene 7 protein, regulator of chromosome condensation and BTB domain-containing protein 1, or E4.5. It is a novel chromosome condensation regulator-like guanine nucleotide exchange factor that may be involved in cell cycle regulation by chromatin remodeling. It may also function as a tumor suppressor that regulates pathways of DNA damage/repair and apoptosis. RCBTB1 may also be a substrate adaptor for a cullin3 (CUL3) E3 ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Biallelic mutations in RCBTB1 may cause isolated and syndromic retinal dystrophy. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349662 [Multi-domain]  Cd Length: 117  Bit Score: 39.55  E-value: 7.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 127 FNNELMADVHFVVGppgaSQKVPAHKYVLAVGSSVFGAMFYGDLAEGESE-IHIPDVEPAAFLILLKYMYSDEIELEADT 205
Cdd:cd18353   15 FDSPETSDLKFRVD----GKYIHVHKAVLKIRCEHFRTMFQSHWNEDMKEvIEIDQFSYPVYRAFLEYLYTDSVDLPPED 90

                         90       100
                 ....*....|....*....|
gi 528511250 206 VLATLYAAKKYIVPALAKAC 225
Cdd:cd18353   91 AIGLLDLATSYCENRLKKLC 110
BTB2_POZ_LZTR1 cd18309
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 146-201 1.06e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349618 [Multi-domain]  Cd Length: 126  Bit Score: 39.29  E-value: 1.06e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 528511250 146 QKVPAHKYVLAVGSSVFGAMFYGDLAE-GESEIHIPDVEPA--AFLILLKYMYSDEIEL 201
Cdd:cd18309   30 HPIPAHKAILAARCSYFEAMFRSFMPEdNTVNISIGEMVPSrqAFDSLLRYIYYGDVTM 88
BTB_POZ_BTBD16 cd18291
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 176-239 1.32e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 16 (BTBD16); BTBD16 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349600  Cd Length: 114  Bit Score: 38.58  E-value: 1.32e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 528511250 176 EIHIPDVEPAAFLILLKYMYSDEIELEADTVLATLYAAKKYIVPALAKACVTFLETSLEAKNAC 239
Cdd:cd18291   49 NINDPLVTKEAFAVALGNLYNSEVEVNVEDAVGVLAAAALLRFPTLFQKCVKVMISSISSSTVC 112
BTB_POZ_ZBTB39 cd18224
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 114-225 1.54e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349533 [Multi-domain]  Cd Length: 123  Bit Score: 38.66  E-value: 1.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 114 STHPT--LRERNALMFNnELMADVHFVVGppgaSQKVPAHKYVLAVGSSVFGAMFYGDLAEGESEIHIPDVEPAAFLILL 191
Cdd:cd18224    7 SDHPNnlLKELNKCRLS-ETMCDVTIVVG----NRSFAAHKAVLACAAGYFQKLFLSTELDVARTYVVDFITPANFEKVL 81

                         90       100       110
                 ....*....|....*....|....*....|....
gi 528511250 192 KYMYSDEIELEADTVLATLYAAKKYIVPALAKAC 225
Cdd:cd18224   82 SFIYTSELFTDLINVGVIYEVAEKLGMEDLLKAC 115
BACK_KLHL35 cd18474
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs ...
 233-305 1.74e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs to the KLHL family. Its function remains unclear. Hypermethylation of KLHL35 is associated with hepatocellular carcinoma and abdominal aortic aneurysm.


Pssm-ID: 350549 [Multi-domain]  Cd Length: 79  Bit Score: 37.49  E-value: 1.74e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 528511250 233 LEAKNACVLLSQSRLFEEPELTLRCWEVIDAQAELALHSEGFCEIDLQTLEIILKRETLNTR-EAVVFQAALDW 305
Cdd:cd18474    1 IGANNCLALLAAADALHCAPLQEHCIRVLLRDFAQAARHPSFLKLELQLVLELLADDSLAVRsEEVVLEAALRW 74
BTB_POZ_KLHL14_printor cd18243
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 109-237 1.84e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349552 [Multi-domain]  Cd Length: 130  Bit Score: 38.48  E-value: 1.84e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 109 TASWQSTHP-TLRERNALMFNNELMADVHFVvgppGASQKVPAHKYVLAVGSSVFGAMFygdlaeGESEIHIPDVEPAAF 187
Cdd:cd18243    8 TSTFDPSHSdNLLHGLNLLWRKQLFCDVTLT----AQGQQFHCHKAVLASCSQYFRSLF------SINNLVLQGCSSIGL 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 528511250 188 LILLKYMYSDEIELEADTVLATLYAAKKYIVPALAKACVTFLETSLEAKN 237
Cdd:cd18243   78 RLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQN 127
BTB_POZ_ZBTB32_FAZF_TZFP cd18218
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 132-225 2.00e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349527 [Multi-domain]  Cd Length: 110  Bit Score: 38.00  E-value: 2.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 132 MADVHFVVGppgaSQKVPAHKYVLAVGSSVFGAMFY----GDLAEGESeihipdVEPAAFLILLKYMYSDEIELEADTVL 207
Cdd:cd18218   18 LCDTLITVG----SQEFPAHSLVLAGASQQLGRQLTnpnpGQWCLGEG------ISPSTFKQLLDFVYGESVEVQPGELR 87

                         90
                 ....*....|....*...
gi 528511250 208 ATLYAAKKYIVPALAKAC 225
Cdd:cd18218   88 PLLEAARALEVESLEEAC 105
BACK_BTBD19 cd18494
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 19 (BTBD19); ...
 237-306 2.71e-03

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB-domain-containing Kelch-like protein. Its function remains unclear.


Pssm-ID: 350569  Cd Length: 73  Bit Score: 36.52  E-value: 2.71e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 237 NACVLLSQSRLFEEPELTLRCWEVIDAQAELALHSEGFCEIDLQTLEIILKRETLNTREAVVFQAALDWA 306
Cdd:cd18494    4 TACEALQAAVTYGQDELKERCLAFIEEHTEEVFKTKGFHELSDEALSVILRSDKLRIDELDILKAVREWA 73
BTB_POZ_BACH cd18955
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 132-229 3.47e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349736 [Multi-domain]  Cd Length: 94  Bit Score: 37.06  E-value: 3.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 132 MADVHFVVGppgaSQKVPAHKYVLAVGSSVFGAMFYGDlAEGESEIHIPD-VEPAAFLILLKYMYSDEIELEADTVLATL 210
Cdd:cd18955    1 LCDVTIVVE----DQRFRAHRAVLAACSDYFLSRVVGQ-TDGDLVITLPEeVTVKGFEPLLQFAYTAKLLLSKENVLEVC 75

                         90
                 ....*....|....*....
gi 528511250 211 YAAKKYIVPALAKACVTFL 229
Cdd:cd18955   76 RCAEFLGVHNIEKACFDFL 94
BTB_POZ_ZBTB45 cd18229
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 150-213 6.94e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349538 [Multi-domain]  Cd Length: 112  Bit Score: 36.38  E-value: 6.94e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 528511250 150 AHKYVLAVGSsvfgAMFYGDLAEGESEIHIPDVEPAAFL-ILLKYMYSDEIELEADTVLATLYAA 213
Cdd:cd18229   32 AHRCVLAAGS----PFFHDKLLLGHSEIEVPPVVPAQTVrQLVEFMYSGSLVVAQSEALQILTAA 92
BTB_POZ_ZBTB17_MIZ1 cd18206
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 131-228 7.35e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349515 [Multi-domain]  Cd Length: 112  Bit Score: 36.45  E-value: 7.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 131 LMADVHFVVGppGASQKvpAHKYVLAVGSSVFGAMFygdlAEGESEIHIpDVEPAAFL-ILLKYMYSDEIELEADTVLAT 209
Cdd:cd18206   21 LLCDCTFVVD--GVDFK--AHKAVLAACSEYFRMLF----VDQKDVVHL-DISNAAGLgQVLEFMYTAKLSLSPENVDDV 91

                         90
                 ....*....|....*....
gi 528511250 210 LYAAKKYIVPALAKACVTF 228
Cdd:cd18206   92 LAVATFLQMQDIVTACHAL 110
BTB_POZ_NPR_plant cd18310
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 133-208 9.18e-03

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349619 [Multi-domain]  Cd Length: 145  Bit Score: 36.90  E-value: 9.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511250 133 ADVHFVV--GPPgasqkVPAHKYVLAVGSSVFGAMFYGDLAEGES---EIHIPDVEPA------AFLILLKYMYSDEIEL 201
Cdd:cd18310   19 SDAEIIVegGRP-----VPVHRCILAARSPFFRDIFASAKAEGANtkpKLELRELIPGgivgydAFMLVLSYLYSGRLRL 93


                 ....*..
gi 528511250 202 EADTVLA 208
Cdd:cd18310   94 VPKEGSA 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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