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Conserved domains on  [gi|528481038|ref|XP_005165675|]
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transcription factor COE2 isoform X1 [Danio rerio]

Protein Classification

transcription factor COE( domain architecture ID 11242836)

transcription factor COE similar to human COE1 and COE2 that recognize variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3, and may play roles in B-cell development

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COE1_DBD pfam16422
Transcription factor COE1 DNA-binding domain;
21-247 9.74e-171

Transcription factor COE1 DNA-binding domain;


:

Pssm-ID: 435333  Cd Length: 227  Bit Score: 483.19  E-value: 9.74e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528481038   21 EEEMDPVRSWVRNVGVIDANIAAQSGVALSRAHFEKQPPSNLRKSNFFHFVLALYDRNGQPVEVERTSFVDFVEQDKEQT 100
Cdd:pfam16422   1 GPSMNSVRNWMQCAGVLDASVAAQSGVGLARAHFEKQPPSNLRKSNFFHFVLALYDRQGQPVEIERTAFIDFVEKEKEPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528481038  101 GEKTNNGTHYKLQLLYSNGVRTEQDLYARLIDSVTKQPISYEGQNKNPEMCRVLLTHEVMCSRCCEKKSCGNRNETPSDP 180
Cdd:pfam16422  81 DEKTNNGIHYRLQLLYSNGIRTEQDLYVRLIDSVTKQAIVYEGQDKNPEMCRVLLTHEVMCSRCCDKKSCGNRNETPSDP 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 528481038  181 VIIDRFFLKFFLKCNQNCLKTAGNPRDMRRFQVVLSTTVCVDGPVLAISDNMFVHNNSKHGRRSRRM 247
Cdd:pfam16422 161 VIIDRFFLKFFMKCNQNCLKNAGNPRDMRRFQVVVSTTVSVDGHVLAVSDNMFVHNNSKHGRRARRL 227
IPT_COE cd01175
IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing ...
 262-346 2.39e-55

IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved in the regulation of the early stages of B-cell differentiation, Drosophila collier is a regulator of the head patterning, and a related protein in Xenopus is involved in primary neurogenesis. All COE family members have a well conserved DNA binding domain that contains an atypical Zn finger motif. The function of the IPT domain is unknown.


:

Pssm-ID: 238580  Cd Length: 85  Bit Score: 181.31  E-value: 2.39e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528481038 262 PCIKAISPSEGWTTGGAMVIVIGENFFDGLQVVFGSMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGAPGR 341
Cdd:cd01175    1 PCIKAISPSEGWTTGGATVIIIGDNFFDGLQVVFGTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGTPGR 80


                 ....*
gi 528481038 342 FIYTA 346
Cdd:cd01175   81 FVYTA 85
COE1_HLH pfam16423
Transcription factor COE1 helix-loop-helix domain; This is the helix-loop-helix domain of ...
 347-390 6.82e-24

Transcription factor COE1 helix-loop-helix domain; This is the helix-loop-helix domain of transcription factor COE1. It is responsible for dimerization.


:

Pssm-ID: 406751  Cd Length: 44  Bit Score: 94.47  E-value: 6.82e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 528481038  347 LNEPTIDYGFQRLQKLIPRHPGDPDKLAKEMLLKRAADVVESLY 390
Cdd:pfam16423   1 LNEPTIDYGFQRLQKLVPRHPGDPERLPKEIILKRAADLAEALY 44
 
Name Accession Description Interval E-value
COE1_DBD pfam16422
Transcription factor COE1 DNA-binding domain;
21-247 9.74e-171

Transcription factor COE1 DNA-binding domain;


Pssm-ID: 435333  Cd Length: 227  Bit Score: 483.19  E-value: 9.74e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528481038   21 EEEMDPVRSWVRNVGVIDANIAAQSGVALSRAHFEKQPPSNLRKSNFFHFVLALYDRNGQPVEVERTSFVDFVEQDKEQT 100
Cdd:pfam16422   1 GPSMNSVRNWMQCAGVLDASVAAQSGVGLARAHFEKQPPSNLRKSNFFHFVLALYDRQGQPVEIERTAFIDFVEKEKEPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528481038  101 GEKTNNGTHYKLQLLYSNGVRTEQDLYARLIDSVTKQPISYEGQNKNPEMCRVLLTHEVMCSRCCEKKSCGNRNETPSDP 180
Cdd:pfam16422  81 DEKTNNGIHYRLQLLYSNGIRTEQDLYVRLIDSVTKQAIVYEGQDKNPEMCRVLLTHEVMCSRCCDKKSCGNRNETPSDP 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 528481038  181 VIIDRFFLKFFLKCNQNCLKTAGNPRDMRRFQVVLSTTVCVDGPVLAISDNMFVHNNSKHGRRSRRM 247
Cdd:pfam16422 161 VIIDRFFLKFFMKCNQNCLKNAGNPRDMRRFQVVVSTTVSVDGHVLAVSDNMFVHNNSKHGRRARRL 227
COE_DBD cd11606
Colier/Olf/Early B-cell factor (EBF) DNA Binding Domain; COE_DBD is the amino-terminal DNA ...
 35-247 7.90e-164

Colier/Olf/Early B-cell factor (EBF) DNA Binding Domain; COE_DBD is the amino-terminal DNA binding domain of the COE protein family. The COE transcription factor is a regulator of development in several organs and tissues that contain the DBD domain as well as IPT/TIG (immunoglobulin-like, Plexins, transcription factors/transcription factor immunoglobulin) and basic helix-loop-helix (bHLH) domains. COE has four members in mammals (COE1-4) with high sequence similarity at the amino-terminal region. COE_DBD requires a zinc ion to bind DNA and contains a zinc finger motif (H-X(3)-C-X(2)-C-X(5)-C) termed the zinc knuckle. COE is homo- or heterodimerized through the bHLH domain to bind DNA. COE1-4 each has a variant due to alternative splicing. However, this alternative splicing does not occur at the DBD domain.


Pssm-ID: 212156  Cd Length: 212  Bit Score: 464.98  E-value: 7.90e-164
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528481038  35 GVIDANiAAQSGVALSRAHFEKQPPSNLRKSNFFHFVLALYDRNGQPVEVERTSFVDFVEQDKEQTGEKTNNGTHYKLQL 114
Cdd:cd11606    1 GVTDPS-AAQTSVGLARAHFEKQPPSNLRKSNFFHFVLALYDRQGQPIEVERTAFVDFVEKEREQGGEKTNNGIHYRLQL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528481038 115 LYSNGVRTEQDLYARLIDSVTKQPISYEGQNKNPEMCRVLLTHEVMCSRCCEKKSCGNRNETPSDPVIIDRFFLKFFLKC 194
Cdd:cd11606   80 LYSNGIRTEQDLYVRLIDSSTKQAIPYEGQDKNPEMCRVLLTHEIMCSRCCEKKSCGNRNETPSDPVIIDRFFLKFFLKC 159

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 528481038 195 NQNCLKTAGNPRDMRRFQVVLSTTVCVDGPVLAISDNMFVHNNSKHGRRSRRM 247
Cdd:cd11606  160 NQNCLKNAGNPRDMRRFQVVLSTTVNVDGHVLAVSDNMFVHNNSKHGRRARRL 212
IPT_COE cd01175
IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing ...
 262-346 2.39e-55

IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved in the regulation of the early stages of B-cell differentiation, Drosophila collier is a regulator of the head patterning, and a related protein in Xenopus is involved in primary neurogenesis. All COE family members have a well conserved DNA binding domain that contains an atypical Zn finger motif. The function of the IPT domain is unknown.


Pssm-ID: 238580  Cd Length: 85  Bit Score: 181.31  E-value: 2.39e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528481038 262 PCIKAISPSEGWTTGGAMVIVIGENFFDGLQVVFGSMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGAPGR 341
Cdd:cd01175    1 PCIKAISPSEGWTTGGATVIIIGDNFFDGLQVVFGTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGTPGR 80


                 ....*
gi 528481038 342 FIYTA 346
Cdd:cd01175   81 FVYTA 85
COE1_HLH pfam16423
Transcription factor COE1 helix-loop-helix domain; This is the helix-loop-helix domain of ...
 347-390 6.82e-24

Transcription factor COE1 helix-loop-helix domain; This is the helix-loop-helix domain of transcription factor COE1. It is responsible for dimerization.


Pssm-ID: 406751  Cd Length: 44  Bit Score: 94.47  E-value: 6.82e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 528481038  347 LNEPTIDYGFQRLQKLIPRHPGDPDKLAKEMLLKRAADVVESLY 390
Cdd:pfam16423   1 LNEPTIDYGFQRLQKLVPRHPGDPERLPKEIILKRAADLAEALY 44
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 262-344 1.15e-13

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 66.70  E-value: 1.15e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528481038  262 PCIKAISPSEGWTTGGAMVIVIGENF---FDGLQVVFGSMLVWSELITPHAIRVQTPPrHIPGVVEVTLSYKSKQFCKGa 338
Cdd:pfam01833   1 PVITSISPSSGPASGGTTITITGSNFgtdSSDLKVTIGGTPCTVISVSSTTIVCTTPP-GTSGLVNVSVTVGGGGISSS- 78


                  ....*.
gi 528481038  339 PGRFIY 344
Cdd:pfam01833  79 PLTFTY 84
IPT smart00429
ig-like, plexins, transcription factors;
262-345 4.02e-06

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 45.10  E-value: 4.02e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528481038   262 PCIKAISPSEGWTTGGAMVIVIGENFFDGlQVVFGSMLVWSELIT-----PHAIRVQTPPRH-IPGVVEV-TLSYKSKQF 334
Cdd:smart00429   2 PVITRISPTSGPVSGGTEITLCGKNLKSI-SVVFVEVGVGEAPCTfspssSTAIVCKTPPYHnIPGSVPVrTVGLRNGGV 80

                           90
                   ....*....|.
gi 528481038   335 cKGAPGRFIYT 345
Cdd:smart00429  81 -PSSPQPFTYV 90
bHLHzip_TFAP4 cd11419
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor AP-4 (TFAP4) and ...
 352-389 3.02e-03

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor AP-4 (TFAP4) and similar proteins; TFAP4, also termed activating enhancer-binding protein 4, or Class C basic helix-loop-helix protein 41 (bHLHc41), is a bHLHzip transcription factor that activates both viral and cellular genes involved in the regulation of cellular proliferation, stemness, and epithelial-mesenchymal transition by binding to the symmetrical DNA sequence 5'-CAGCTG-3'.


Pssm-ID: 381425  Cd Length: 61  Bit Score: 36.14  E-value: 3.02e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 528481038 352 IDYGFQRLQKLIPRHPGdpDKLAKEMLLKRAADVVESL 389
Cdd:cd11419   19 INAGFQSLRTLLPHCDG--EKLSKAAILQQTAEYIFSL 54
 
Name Accession Description Interval E-value
COE1_DBD pfam16422
Transcription factor COE1 DNA-binding domain;
21-247 9.74e-171

Transcription factor COE1 DNA-binding domain;


Pssm-ID: 435333  Cd Length: 227  Bit Score: 483.19  E-value: 9.74e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528481038   21 EEEMDPVRSWVRNVGVIDANIAAQSGVALSRAHFEKQPPSNLRKSNFFHFVLALYDRNGQPVEVERTSFVDFVEQDKEQT 100
Cdd:pfam16422   1 GPSMNSVRNWMQCAGVLDASVAAQSGVGLARAHFEKQPPSNLRKSNFFHFVLALYDRQGQPVEIERTAFIDFVEKEKEPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528481038  101 GEKTNNGTHYKLQLLYSNGVRTEQDLYARLIDSVTKQPISYEGQNKNPEMCRVLLTHEVMCSRCCEKKSCGNRNETPSDP 180
Cdd:pfam16422  81 DEKTNNGIHYRLQLLYSNGIRTEQDLYVRLIDSVTKQAIVYEGQDKNPEMCRVLLTHEVMCSRCCDKKSCGNRNETPSDP 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 528481038  181 VIIDRFFLKFFLKCNQNCLKTAGNPRDMRRFQVVLSTTVCVDGPVLAISDNMFVHNNSKHGRRSRRM 247
Cdd:pfam16422 161 VIIDRFFLKFFMKCNQNCLKNAGNPRDMRRFQVVVSTTVSVDGHVLAVSDNMFVHNNSKHGRRARRL 227
COE_DBD cd11606
Colier/Olf/Early B-cell factor (EBF) DNA Binding Domain; COE_DBD is the amino-terminal DNA ...
 35-247 7.90e-164

Colier/Olf/Early B-cell factor (EBF) DNA Binding Domain; COE_DBD is the amino-terminal DNA binding domain of the COE protein family. The COE transcription factor is a regulator of development in several organs and tissues that contain the DBD domain as well as IPT/TIG (immunoglobulin-like, Plexins, transcription factors/transcription factor immunoglobulin) and basic helix-loop-helix (bHLH) domains. COE has four members in mammals (COE1-4) with high sequence similarity at the amino-terminal region. COE_DBD requires a zinc ion to bind DNA and contains a zinc finger motif (H-X(3)-C-X(2)-C-X(5)-C) termed the zinc knuckle. COE is homo- or heterodimerized through the bHLH domain to bind DNA. COE1-4 each has a variant due to alternative splicing. However, this alternative splicing does not occur at the DBD domain.


Pssm-ID: 212156  Cd Length: 212  Bit Score: 464.98  E-value: 7.90e-164
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528481038  35 GVIDANiAAQSGVALSRAHFEKQPPSNLRKSNFFHFVLALYDRNGQPVEVERTSFVDFVEQDKEQTGEKTNNGTHYKLQL 114
Cdd:cd11606    1 GVTDPS-AAQTSVGLARAHFEKQPPSNLRKSNFFHFVLALYDRQGQPIEVERTAFVDFVEKEREQGGEKTNNGIHYRLQL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528481038 115 LYSNGVRTEQDLYARLIDSVTKQPISYEGQNKNPEMCRVLLTHEVMCSRCCEKKSCGNRNETPSDPVIIDRFFLKFFLKC 194
Cdd:cd11606   80 LYSNGIRTEQDLYVRLIDSSTKQAIPYEGQDKNPEMCRVLLTHEIMCSRCCEKKSCGNRNETPSDPVIIDRFFLKFFLKC 159

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 528481038 195 NQNCLKTAGNPRDMRRFQVVLSTTVCVDGPVLAISDNMFVHNNSKHGRRSRRM 247
Cdd:cd11606  160 NQNCLKNAGNPRDMRRFQVVLSTTVNVDGHVLAVSDNMFVHNNSKHGRRARRL 212
IPT_COE cd01175
IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing ...
 262-346 2.39e-55

IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved in the regulation of the early stages of B-cell differentiation, Drosophila collier is a regulator of the head patterning, and a related protein in Xenopus is involved in primary neurogenesis. All COE family members have a well conserved DNA binding domain that contains an atypical Zn finger motif. The function of the IPT domain is unknown.


Pssm-ID: 238580  Cd Length: 85  Bit Score: 181.31  E-value: 2.39e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528481038 262 PCIKAISPSEGWTTGGAMVIVIGENFFDGLQVVFGSMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGAPGR 341
Cdd:cd01175    1 PCIKAISPSEGWTTGGATVIIIGDNFFDGLQVVFGTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGTPGR 80


                 ....*
gi 528481038 342 FIYTA 346
Cdd:cd01175   81 FVYTA 85
COE1_HLH pfam16423
Transcription factor COE1 helix-loop-helix domain; This is the helix-loop-helix domain of ...
 347-390 6.82e-24

Transcription factor COE1 helix-loop-helix domain; This is the helix-loop-helix domain of transcription factor COE1. It is responsible for dimerization.


Pssm-ID: 406751  Cd Length: 44  Bit Score: 94.47  E-value: 6.82e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 528481038  347 LNEPTIDYGFQRLQKLIPRHPGDPDKLAKEMLLKRAADVVESLY 390
Cdd:pfam16423   1 LNEPTIDYGFQRLQKLVPRHPGDPERLPKEIILKRAADLAEALY 44
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 262-344 1.15e-13

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 66.70  E-value: 1.15e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528481038  262 PCIKAISPSEGWTTGGAMVIVIGENF---FDGLQVVFGSMLVWSELITPHAIRVQTPPrHIPGVVEVTLSYKSKQFCKGa 338
Cdd:pfam01833   1 PVITSISPSSGPASGGTTITITGSNFgtdSSDLKVTIGGTPCTVISVSSTTIVCTTPP-GTSGLVNVSVTVGGGGISSS- 78


                  ....*.
gi 528481038  339 PGRFIY 344
Cdd:pfam01833  79 PLTFTY 84
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 262-345 2.42e-10

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 57.09  E-value: 2.42e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528481038 262 PCIKAISPSEGWTTGGAMVIVIGENFFDG--LQVVFGSMLVWSEL-ITPHAIRVQTPPRHI--PGVVEVTLSYKSkQFCK 336
Cdd:cd00102    1 PVITSISPSSGPVSGGTEVTITGSNFGSGsnLRVTFGGGVPCSVLsVSSTAIVCTTPPYANpgPGPVEVTVDRGN-GGIT 79


                 ....*....
gi 528481038 337 GAPGRFIYT 345
Cdd:cd00102   80 SSPLTFTYV 88
IPT smart00429
ig-like, plexins, transcription factors;
262-345 4.02e-06

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 45.10  E-value: 4.02e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528481038   262 PCIKAISPSEGWTTGGAMVIVIGENFFDGlQVVFGSMLVWSELIT-----PHAIRVQTPPRH-IPGVVEV-TLSYKSKQF 334
Cdd:smart00429   2 PVITRISPTSGPVSGGTEITLCGKNLKSI-SVVFVEVGVGEAPCTfspssSTAIVCKTPPYHnIPGSVPVrTVGLRNGGV 80

                           90
                   ....*....|.
gi 528481038   335 cKGAPGRFIYT 345
Cdd:smart00429  81 -PSSPQPFTYV 90
bHLHzip_TFAP4 cd11419
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor AP-4 (TFAP4) and ...
 352-389 3.02e-03

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor AP-4 (TFAP4) and similar proteins; TFAP4, also termed activating enhancer-binding protein 4, or Class C basic helix-loop-helix protein 41 (bHLHc41), is a bHLHzip transcription factor that activates both viral and cellular genes involved in the regulation of cellular proliferation, stemness, and epithelial-mesenchymal transition by binding to the symmetrical DNA sequence 5'-CAGCTG-3'.


Pssm-ID: 381425  Cd Length: 61  Bit Score: 36.14  E-value: 3.02e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 528481038 352 IDYGFQRLQKLIPRHPGdpDKLAKEMLLKRAADVVESL 389
Cdd:cd11419   19 INAGFQSLRTLLPHCDG--EKLSKAAILQQTAEYIFSL 54
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 262-345 7.49e-03

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 35.89  E-value: 7.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528481038 262 PCIKAISPSEGWTTGGAMVIVIGENF---FDGLQVVFGSMLVWSELITPHAIRVQTPPRHIP--GVVEVTLSYKSKQFCK 336
Cdd:cd00603    1 PVITSISPSSGPLSGGTRLTITGSNLgsgSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPgeGPVEVTVDGANVSARV 80


                 ....*....
gi 528481038 337 GAPGRFIYT 345
Cdd:cd00603   81 LSNTTFTYV 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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