NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|528479264|ref|XP_005171883|]
View 

AN1-type zinc finger protein 5 isoform X1 [Danio rerio]

Protein Classification

zinc finger A20 and AN1 domain-containing stress-associated protein( domain architecture ID 10484704)

zinc finger A20 and AN1 domain-containing stress-associated protein similar to Homo sapiens AN1-type zinc finger protein that is involved in protein degradation via the ubiquitin-proteasome system

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ZnF_AN1 smart00154
AN1-like Zinc finger; Zinc finger at the C-terminus of An1, a ubiquitin-like protein in ...
 155-192 1.72e-14

AN1-like Zinc finger; Zinc finger at the C-terminus of An1, a ubiquitin-like protein in Xenopus laevis.


:

Pssm-ID: 197545  Cd Length: 39  Bit Score: 64.72  E-value: 1.72e-14
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 528479264   155 CFTCRKRVGLTGFDCR-CGNLFCGIHRYSDKHNCTYDYK 192
Cdd:smart00154   1 CHFCRKKVGLTGFKCRhCGNLFCGEHRLPEDHDCPGDYK 39
zf-A20 pfam01754
A20-like zinc finger; The A20 Zn-finger of bovine/human Rabex5/rabGEF1 is a Ubiquitin Binding ...
 12-35 1.41e-09

A20-like zinc finger; The A20 Zn-finger of bovine/human Rabex5/rabGEF1 is a Ubiquitin Binding Domain. The zinc finger mediates self-association in A20. These fingers also mediate IL-1-induced NF-kappa B activation.


:

Pssm-ID: 460313  Cd Length: 24  Bit Score: 51.35  E-value: 1.41e-09
                          10        20
                  ....*....|....*....|....
gi 528479264   12 ILCTTGCGFYGNPRTNGMCSVCYK 35
Cdd:pfam01754   1 LLCRNGCGFYGSPATNGLCSKCYK 24
DamX super family cl34574
Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell ...
 37-152 1.14e-03

Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell cycle control, cell division, chromosome partitioning];


The actual alignment was detected with superfamily member COG3266:

Pssm-ID: 442497 [Multi-domain]  Cd Length: 455  Bit Score: 39.45  E-value: 1.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528479264  37 HLNRQQSSDRSPMSPLAAGSPSAEASAIQRLEASINKAETLPAPSTETMRESipsSSLPVTQkMTEMSISREEKALSPKA 116
Cdd:COG3266  247 LLLIIGSALKAPSQASSASAPATTSLGEQQEVSLPPAVAAQPAAAAAAQPSA---VALPAAP-AAAAAAAAPAEAAAPQP 322

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 528479264 117 ETVEPVITQPTSSYSPIPVAQAndDAKSPDSSKPKK 152
Cdd:COG3266  323 TAAKPVVTETAAPAAPAPEAAA--AAAAPAAPAVAK 356
 
Name Accession Description Interval E-value
ZnF_AN1 smart00154
AN1-like Zinc finger; Zinc finger at the C-terminus of An1, a ubiquitin-like protein in ...
 155-192 1.72e-14

AN1-like Zinc finger; Zinc finger at the C-terminus of An1, a ubiquitin-like protein in Xenopus laevis.


Pssm-ID: 197545  Cd Length: 39  Bit Score: 64.72  E-value: 1.72e-14
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 528479264   155 CFTCRKRVGLTGFDCR-CGNLFCGIHRYSDKHNCTYDYK 192
Cdd:smart00154   1 CHFCRKKVGLTGFKCRhCGNLFCGEHRLPEDHDCPGDYK 39
zf-A20 pfam01754
A20-like zinc finger; The A20 Zn-finger of bovine/human Rabex5/rabGEF1 is a Ubiquitin Binding ...
 12-35 1.41e-09

A20-like zinc finger; The A20 Zn-finger of bovine/human Rabex5/rabGEF1 is a Ubiquitin Binding Domain. The zinc finger mediates self-association in A20. These fingers also mediate IL-1-induced NF-kappa B activation.


Pssm-ID: 460313  Cd Length: 24  Bit Score: 51.35  E-value: 1.41e-09
                          10        20
                  ....*....|....*....|....
gi 528479264   12 ILCTTGCGFYGNPRTNGMCSVCYK 35
Cdd:pfam01754   1 LLCRNGCGFYGSPATNGLCSKCYK 24
zf-AN1 pfam01428
AN1-like Zinc finger; Zinc finger at the C-terminus of An1, a ubiquitin-like protein in ...
 157-189 1.85e-06

AN1-like Zinc finger; Zinc finger at the C-terminus of An1, a ubiquitin-like protein in Xenopus laevis. The following pattern describes the zinc finger. C-X2-C-X(9-12)-C-X(1-2)-C-X4-C-X2-H-X5-H-X-C Where X can be any amino acid, and numbers in brackets indicate the number of residues.


Pssm-ID: 460208  Cd Length: 37  Bit Score: 43.06  E-value: 1.85e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 528479264  157 TCRKRVGLTgFDCR-CGNLFCGIHRYSDKHNCTY 189
Cdd:pfam01428   5 GCKKKDFLP-FKCRfCGKNFCLKHRLPEDHDCSG 37
ZnF_A20 smart00259
A20-like zinc fingers; A20- (an inhibitor of cell death)-like zinc fingers. The zinc finger ...
 11-35 7.67e-06

A20-like zinc fingers; A20- (an inhibitor of cell death)-like zinc fingers. The zinc finger mediates self-association in A20. These fingers also mediate IL-1-induced NF-kappaB activation.


Pssm-ID: 128555  Cd Length: 26  Bit Score: 41.42  E-value: 7.67e-06
                           10        20
                   ....*....|....*....|....*.
gi 528479264    11 PILC-TTGCGFYGNPRTNGMCSVCYK 35
Cdd:smart00259   1 PIKCrRPGCGFFGNPATEGLCSKCFK 26
DamX COG3266
Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell ...
 37-152 1.14e-03

Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442497 [Multi-domain]  Cd Length: 455  Bit Score: 39.45  E-value: 1.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528479264  37 HLNRQQSSDRSPMSPLAAGSPSAEASAIQRLEASINKAETLPAPSTETMRESipsSSLPVTQkMTEMSISREEKALSPKA 116
Cdd:COG3266  247 LLLIIGSALKAPSQASSASAPATTSLGEQQEVSLPPAVAAQPAAAAAAQPSA---VALPAAP-AAAAAAAAPAEAAAPQP 322

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 528479264 117 ETVEPVITQPTSSYSPIPVAQAndDAKSPDSSKPKK 152
Cdd:COG3266  323 TAAKPVVTETAAPAAPAPEAAA--AAAAPAAPAVAK 356
FYVE1_Vac1p_like cd15761
FYVE-related domain 1 found in yeast protein VAC1 (Vac1p) and similar proteins; Vac1p, also ...
 151-179 3.61e-03

FYVE-related domain 1 found in yeast protein VAC1 (Vac1p) and similar proteins; Vac1p, also termed vacuolar segregation protein Pep7p, or carboxypeptidase Y-deficient protein 7, or vacuolar protein sorting-associated protein 19 (Vps19p), or vacuolar protein-targeting protein 19, is a phosphatidylinositol 3-phosphate (PtdIns3P or PI3P)-binding protein that interacts with a Rab GTPase, GTP-bound form of Vps21p, and a Sec1p homologue, Vps45p, to facilitate Vps45p-dependent vesicle-mediated vacuolar protein sorting. It also acts as a novel regulator of vesicle docking and/or fusion at the endosome and functions in vesicle-mediated transport of Golgi precursor carboxypeptidase Y (CPY), protease A (PrA), protease B (PrB), but not alkaline phosphatase (ALP) from the trans-Golgi network-like compartment (TGN) to the endosome. Vac1p contains an N-terminal classical TFIIIA-like zinc finger, two putative zinc-binding FYVE fingers, and a C-terminal coiled coil region. The family corresponds to the first FYVE domain, which resembles the FYVE-related domain as it has an altered sequence in the basic ligand binding patch.


Pssm-ID: 277300  Cd Length: 76  Bit Score: 34.94  E-value: 3.61e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 528479264 151 KKNRCFTCRKRVG-LTGF-DCR-CGNLFCGIH 179
Cdd:cd15761    9 GKSRCSECGKTLNkKNGIvNCRkCGELFCNEH 40
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
41-136 8.61e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 36.68  E-value: 8.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528479264  41 QQSSDRSPMSPLAAGSPSAEASAIQRleaSINKAETLPAPSTETMRESIPSSSLPVTQKMTEMSISREEKA-LSPKAETV 119
Cdd:PRK14971 402 PSQSSAAAQPSAPQSATQPAGTPPTV---SVDPPAAVPVNPPSTAPQAVRPAQFKEEKKIPVSKVSSLGPStLRPIQEKA 478

                         90
                 ....*....|....*..
gi 528479264 120 EpvitQPTSSYSPIPVA 136
Cdd:PRK14971 479 E----QATGNIKEAPTG 491
 
Name Accession Description Interval E-value
ZnF_AN1 smart00154
AN1-like Zinc finger; Zinc finger at the C-terminus of An1, a ubiquitin-like protein in ...
 155-192 1.72e-14

AN1-like Zinc finger; Zinc finger at the C-terminus of An1, a ubiquitin-like protein in Xenopus laevis.


Pssm-ID: 197545  Cd Length: 39  Bit Score: 64.72  E-value: 1.72e-14
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 528479264   155 CFTCRKRVGLTGFDCR-CGNLFCGIHRYSDKHNCTYDYK 192
Cdd:smart00154   1 CHFCRKKVGLTGFKCRhCGNLFCGEHRLPEDHDCPGDYK 39
zf-A20 pfam01754
A20-like zinc finger; The A20 Zn-finger of bovine/human Rabex5/rabGEF1 is a Ubiquitin Binding ...
 12-35 1.41e-09

A20-like zinc finger; The A20 Zn-finger of bovine/human Rabex5/rabGEF1 is a Ubiquitin Binding Domain. The zinc finger mediates self-association in A20. These fingers also mediate IL-1-induced NF-kappa B activation.


Pssm-ID: 460313  Cd Length: 24  Bit Score: 51.35  E-value: 1.41e-09
                          10        20
                  ....*....|....*....|....
gi 528479264   12 ILCTTGCGFYGNPRTNGMCSVCYK 35
Cdd:pfam01754   1 LLCRNGCGFYGSPATNGLCSKCYK 24
zf-AN1 pfam01428
AN1-like Zinc finger; Zinc finger at the C-terminus of An1, a ubiquitin-like protein in ...
 157-189 1.85e-06

AN1-like Zinc finger; Zinc finger at the C-terminus of An1, a ubiquitin-like protein in Xenopus laevis. The following pattern describes the zinc finger. C-X2-C-X(9-12)-C-X(1-2)-C-X4-C-X2-H-X5-H-X-C Where X can be any amino acid, and numbers in brackets indicate the number of residues.


Pssm-ID: 460208  Cd Length: 37  Bit Score: 43.06  E-value: 1.85e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 528479264  157 TCRKRVGLTgFDCR-CGNLFCGIHRYSDKHNCTY 189
Cdd:pfam01428   5 GCKKKDFLP-FKCRfCGKNFCLKHRLPEDHDCSG 37
ZnF_A20 smart00259
A20-like zinc fingers; A20- (an inhibitor of cell death)-like zinc fingers. The zinc finger ...
 11-35 7.67e-06

A20-like zinc fingers; A20- (an inhibitor of cell death)-like zinc fingers. The zinc finger mediates self-association in A20. These fingers also mediate IL-1-induced NF-kappaB activation.


Pssm-ID: 128555  Cd Length: 26  Bit Score: 41.42  E-value: 7.67e-06
                           10        20
                   ....*....|....*....|....*.
gi 528479264    11 PILC-TTGCGFYGNPRTNGMCSVCYK 35
Cdd:smart00259   1 PIKCrRPGCGFFGNPATEGLCSKCFK 26
DamX COG3266
Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell ...
 37-152 1.14e-03

Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442497 [Multi-domain]  Cd Length: 455  Bit Score: 39.45  E-value: 1.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528479264  37 HLNRQQSSDRSPMSPLAAGSPSAEASAIQRLEASINKAETLPAPSTETMRESipsSSLPVTQkMTEMSISREEKALSPKA 116
Cdd:COG3266  247 LLLIIGSALKAPSQASSASAPATTSLGEQQEVSLPPAVAAQPAAAAAAQPSA---VALPAAP-AAAAAAAAPAEAAAPQP 322

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 528479264 117 ETVEPVITQPTSSYSPIPVAQAndDAKSPDSSKPKK 152
Cdd:COG3266  323 TAAKPVVTETAAPAAPAPEAAA--AAAAPAAPAVAK 356
FYVE1_Vac1p_like cd15761
FYVE-related domain 1 found in yeast protein VAC1 (Vac1p) and similar proteins; Vac1p, also ...
 151-179 3.61e-03

FYVE-related domain 1 found in yeast protein VAC1 (Vac1p) and similar proteins; Vac1p, also termed vacuolar segregation protein Pep7p, or carboxypeptidase Y-deficient protein 7, or vacuolar protein sorting-associated protein 19 (Vps19p), or vacuolar protein-targeting protein 19, is a phosphatidylinositol 3-phosphate (PtdIns3P or PI3P)-binding protein that interacts with a Rab GTPase, GTP-bound form of Vps21p, and a Sec1p homologue, Vps45p, to facilitate Vps45p-dependent vesicle-mediated vacuolar protein sorting. It also acts as a novel regulator of vesicle docking and/or fusion at the endosome and functions in vesicle-mediated transport of Golgi precursor carboxypeptidase Y (CPY), protease A (PrA), protease B (PrB), but not alkaline phosphatase (ALP) from the trans-Golgi network-like compartment (TGN) to the endosome. Vac1p contains an N-terminal classical TFIIIA-like zinc finger, two putative zinc-binding FYVE fingers, and a C-terminal coiled coil region. The family corresponds to the first FYVE domain, which resembles the FYVE-related domain as it has an altered sequence in the basic ligand binding patch.


Pssm-ID: 277300  Cd Length: 76  Bit Score: 34.94  E-value: 3.61e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 528479264 151 KKNRCFTCRKRVG-LTGF-DCR-CGNLFCGIH 179
Cdd:cd15761    9 GKSRCSECGKTLNkKNGIvNCRkCGELFCNEH 40
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
41-136 8.61e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 36.68  E-value: 8.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528479264  41 QQSSDRSPMSPLAAGSPSAEASAIQRleaSINKAETLPAPSTETMRESIPSSSLPVTQKMTEMSISREEKA-LSPKAETV 119
Cdd:PRK14971 402 PSQSSAAAQPSAPQSATQPAGTPPTV---SVDPPAAVPVNPPSTAPQAVRPAQFKEEKKIPVSKVSSLGPStLRPIQEKA 478

                         90
                 ....*....|....*..
gi 528479264 120 EpvitQPTSSYSPIPVA 136
Cdd:PRK14971 479 E----QATGNIKEAPTG 491
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH