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Conserved domains on  [gi|530364531|ref|XP_005245130|]
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rho GTPase-activating protein 30 isoform X2 [Homo sapiens]

Protein Classification

Rho GTPase-activating protein( domain architecture ID 1569)

Rho GTPase-activating protein for Rho/Rac/Cdc42-like small GTPases that act as molecular switches, active in their GTP-bound form but inactive when bound to GDP

CATH:  1.10.555.10
Gene Ontology:  GO:0007165|GO:0005096
PubMed:  17222083|12480336
SCOP:  4001255

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RhoGAP super family cl02570
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 1-62 2.18e-27

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


The actual alignment was detected with superfamily member cd04384:

Pssm-ID: 470621 [Multi-domain]  Cd Length: 195  Bit Score: 110.29  E-value: 2.18e-27
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530364531   1 MRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDIEASGFNGTAAFMEVRVQSIVVEFILTH 62
Cdd:cd04384  134 MRHLSRLAKYCSITNMHAKNLAIVWAPNLLRSKQIESACFSGTAAFMEVRIQSVVVEFILNH 195
2A1904 super family cl36772
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 525-739 3.59e-08

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


The actual alignment was detected with superfamily member TIGR00927:

Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 57.70  E-value: 3.59e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364531   525 EEAEGSPETKVEAGKASEDRGEAGGSQETKVRL---------REGSRE---ETEAKEEKSKGQKKADSMEAKGVEEPGGD 592
Cdd:TIGR00927  647 EEGERPTEAEGENGEESGGEAEQEGETETKGENesegeipaeRKGEQEgegEIEAKEADHKGETEAEEVEHEGETEAEGT 726

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364531   593 EYTDEKEKEIEREEDEQREEAQVEAGRDLEQGAQEDQVAeekwevVQKQEAEGVREDEDKGQREKGyhEARKDQGDGEDS 672
Cdd:TIGR00927  727 EDEGEIETGEEGEEVEDEGEGEAEGKHEVETEGDRKETE------HEGETEAEGKEDEDEGEIQAG--EDGEMKGDEGAE 798

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364531   673 RSPEAATEGGAGEvSKERESGDGEAEGDQRAGGYYLEEDTLSEGSGVASLE---VDCAKEGNPHSSEMEE 739
Cdd:TIGR00927  799 GKVEHEGETEAGE-KDEHEGQSETQADDTEVKDETGEQELNAENQGEAKQDekgVDGGGGSDGGDSEEEE 867
 
Name Accession Description Interval E-value
RhoGAP_CdGAP cd04384
RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 1-62 2.18e-27

RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to focal adhesions via the interaction with the scaffold protein actopaxin (alpha-parvin). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239849 [Multi-domain]  Cd Length: 195  Bit Score: 110.29  E-value: 2.18e-27
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530364531   1 MRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDIEASGFNGTAAFMEVRVQSIVVEFILTH 62
Cdd:cd04384  134 MRHLSRLAKYCSITNMHAKNLAIVWAPNLLRSKQIESACFSGTAAFMEVRIQSVVVEFILNH 195
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 1-63 6.02e-11

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 62.28  E-value: 6.02e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530364531     1 MRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDieasgfNGTAAFMEVRVQSIVVEFILTHV 63
Cdd:smart00324 118 LAHLNRVAEHSEENKMTARNLAIVFGPTLLRPPD------GEVASLKDIRHQNTVIEFLIENA 174
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 1-34 1.42e-08

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 54.47  E-value: 1.42e-08
                          10        20        30
                  ....*....|....*....|....*....|....
gi 530364531    1 MRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKD 34
Cdd:pfam00620 115 LAHLNRVAQNSDVNKMNAHNLAIVFGPTLLRPPD 148
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 525-739 3.59e-08

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 57.70  E-value: 3.59e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364531   525 EEAEGSPETKVEAGKASEDRGEAGGSQETKVRL---------REGSRE---ETEAKEEKSKGQKKADSMEAKGVEEPGGD 592
Cdd:TIGR00927  647 EEGERPTEAEGENGEESGGEAEQEGETETKGENesegeipaeRKGEQEgegEIEAKEADHKGETEAEEVEHEGETEAEGT 726

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364531   593 EYTDEKEKEIEREEDEQREEAQVEAGRDLEQGAQEDQVAeekwevVQKQEAEGVREDEDKGQREKGyhEARKDQGDGEDS 672
Cdd:TIGR00927  727 EDEGEIETGEEGEEVEDEGEGEAEGKHEVETEGDRKETE------HEGETEAEGKEDEDEGEIQAG--EDGEMKGDEGAE 798

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364531   673 RSPEAATEGGAGEvSKERESGDGEAEGDQRAGGYYLEEDTLSEGSGVASLE---VDCAKEGNPHSSEMEE 739
Cdd:TIGR00927  799 GKVEHEGETEAGE-KDEHEGQSETQADDTEVKDETGEQELNAENQGEAKQDekgVDGGGGSDGGDSEEEE 867
PTZ00121 PTZ00121
MAEBL; Provisional
 525-703 1.33e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 46.29  E-value: 1.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364531  525 EEAEGSPETKVEAGKASEDRGEAGGSQETKVRLR-EGSREETEAKEEKSKGQKKADSMEAKGVEEPGGDEYTDEKEKEIE 603
Cdd:PTZ00121 1339 EEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKkEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKK 1418

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364531  604 REEDEQREEAQVEAGRDLEQGAQEDQVAEEkwevvQKQEAEGVREDEDKGQREKGYHEARKDQGDGEDSRSPEAATEgGA 683
Cdd:PTZ00121 1419 KADEAKKKAEEKKKADEAKKKAEEAKKADE-----AKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKK-KA 1492

                         170       180
                  ....*....|....*....|
gi 530364531  684 GEVSKERESGDGEAEGDQRA 703
Cdd:PTZ00121 1493 EEAKKKADEAKKAAEAKKKA 1512
 
Name Accession Description Interval E-value
RhoGAP_CdGAP cd04384
RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 1-62 2.18e-27

RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to focal adhesions via the interaction with the scaffold protein actopaxin (alpha-parvin). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239849 [Multi-domain]  Cd Length: 195  Bit Score: 110.29  E-value: 2.18e-27
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530364531   1 MRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDIEASGFNGTAAFMEVRVQSIVVEFILTH 62
Cdd:cd04384  134 MRHLSRLAKYCSITNMHAKNLAIVWAPNLLRSKQIESACFSGTAAFMEVRIQSVVVEFILNH 195
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 1-63 6.02e-11

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 62.28  E-value: 6.02e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530364531     1 MRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDieasgfNGTAAFMEVRVQSIVVEFILTHV 63
Cdd:smart00324 118 LAHLNRVAEHSEENKMTARNLAIVFGPTLLRPPD------GEVASLKDIRHQNTVIEFLIENA 174
RhoGAP cd00159
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 1-62 2.47e-09

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


Pssm-ID: 238090 [Multi-domain]  Cd Length: 169  Bit Score: 57.31  E-value: 2.47e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530364531   1 MRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDIEASgfngtaAFMEVRVQSIVVEFILTH 62
Cdd:cd00159  114 LKLLHKISQNSEVNKMTASNLAIVFAPTLLRPPDSDDE------LLEDIKKLNEIVEFLIEN 169
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 1-34 1.42e-08

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 54.47  E-value: 1.42e-08
                          10        20        30
                  ....*....|....*....|....*....|....
gi 530364531    1 MRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKD 34
Cdd:pfam00620 115 LAHLNRVAQNSDVNKMNAHNLAIVFGPTLLRPPD 148
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 525-739 3.59e-08

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 57.70  E-value: 3.59e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364531   525 EEAEGSPETKVEAGKASEDRGEAGGSQETKVRL---------REGSRE---ETEAKEEKSKGQKKADSMEAKGVEEPGGD 592
Cdd:TIGR00927  647 EEGERPTEAEGENGEESGGEAEQEGETETKGENesegeipaeRKGEQEgegEIEAKEADHKGETEAEEVEHEGETEAEGT 726

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364531   593 EYTDEKEKEIEREEDEQREEAQVEAGRDLEQGAQEDQVAeekwevVQKQEAEGVREDEDKGQREKGyhEARKDQGDGEDS 672
Cdd:TIGR00927  727 EDEGEIETGEEGEEVEDEGEGEAEGKHEVETEGDRKETE------HEGETEAEGKEDEDEGEIQAG--EDGEMKGDEGAE 798

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364531   673 RSPEAATEGGAGEvSKERESGDGEAEGDQRAGGYYLEEDTLSEGSGVASLE---VDCAKEGNPHSSEMEE 739
Cdd:TIGR00927  799 GKVEHEGETEAGE-KDEHEGQSETQADDTEVKDETGEQELNAENQGEAKQDekgVDGGGGSDGGDSEEEE 867
RhoGAP_nadrin cd04386
RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 1-71 5.31e-06

RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in tight junction maintenance in mammalian epithelium. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239851  Cd Length: 203  Bit Score: 48.22  E-value: 5.31e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530364531   1 MRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKdIEASGFNGTAAfMEVRVqSIVVEFILTHVDQLFGGAA 71
Cdd:cd04386  136 IKFLSKLAQKSDENKMSPSNIAIVLAPNLLWAK-NEGSLAEMAAG-TSVHV-VAIVELIISHADWFFPGEV 203
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 464-701 1.49e-05

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 49.22  E-value: 1.49e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364531   464 AYDDLSPLLGPKPPIWKGSGSLEGEAAGCGRQALGQGGEEQACWEVGEDKQAEPGGRLDIREEAEGSPETKveaGKASED 543
Cdd:TIGR00927  626 ALGDLSKGDVAEAEHTGERTGEEGERPTEAEGENGEESGGEAEQEGETETKGENESEGEIPAERKGEQEGE---GEIEAK 702

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364531   544 RGEAGGSQETKVRLREGSRE--------ETEAKEE-KSKGQKKADSMEAKGVEEPGGDEYTDEKEKEIEREEDEQREEAQ 614
Cdd:TIGR00927  703 EADHKGETEAEEVEHEGETEaegtedegEIETGEEgEEVEDEGEGEAEGKHEVETEGDRKETEHEGETEAEGKEDEDEGE 782

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364531   615 VEAGRDLE-------QGAQEDQVAEEKWEVVQKQEAEGVREDEDKGQREKGYHEARK-------------------DQGD 668
Cdd:TIGR00927  783 IQAGEDGEmkgdegaEGKVEHEGETEAGEKDEHEGQSETQADDTEVKDETGEQELNAenqgeakqdekgvdggggsDGGD 862

                          250       260       270
                   ....*....|....*....|....*....|...
gi 530364531   669 GEDSRSPEAATEggaGEVSKERESGDGEAEGDQ 701
Cdd:TIGR00927  863 SEEEEEEEEEEE---EEEEEEEEEEEEEEENEE 892
RhoGAP_chimaerin cd04372
RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 1-67 3.43e-05

RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms that each contain a C-terminal GAP domain, and a central C1 domain which binds phorbol esters, inducing a conformational change that activates the protein; one splice form is lacking the N-terminal Src homology-2 (SH2) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239837 [Multi-domain]  Cd Length: 194  Bit Score: 45.59  E-value: 3.43e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 530364531   1 MRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDIEASgfngtAAFMEVRVQSIVVEFILTHVDQLF 67
Cdd:cd04372  133 MEHLKRVTLHEKDNKMNAENLGIVFGPTLMRPPEDSAL-----TTLNDMRYQILIVQLLITNEDVLF 194
PTZ00121 PTZ00121
MAEBL; Provisional
 525-703 1.33e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 46.29  E-value: 1.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364531  525 EEAEGSPETKVEAGKASEDRGEAGGSQETKVRLR-EGSREETEAKEEKSKGQKKADSMEAKGVEEPGGDEYTDEKEKEIE 603
Cdd:PTZ00121 1339 EEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKkEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKK 1418

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364531  604 REEDEQREEAQVEAGRDLEQGAQEDQVAEEkwevvQKQEAEGVREDEDKGQREKGYHEARKDQGDGEDSRSPEAATEgGA 683
Cdd:PTZ00121 1419 KADEAKKKAEEKKKADEAKKKAEEAKKADE-----AKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKK-KA 1492

                         170       180
                  ....*....|....*....|
gi 530364531  684 GEVSKERESGDGEAEGDQRA 703
Cdd:PTZ00121 1493 EEAKKKADEAKKAAEAKKKA 1512
RhoGAP_Graf cd04374
RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase ...
 1-62 1.96e-04

RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal changes mediated by Rho proteins. Graf exhibits GAP activity toward RhoA and Cdc42, but only weakly activates Rac1. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239839  Cd Length: 203  Bit Score: 43.54  E-value: 1.96e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530364531   1 MRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDieasgfNGTAAFMEVRVQSIVVEFILTH 62
Cdd:cd04374  148 IKHLTNVSDHSKKNLMTVSNLGVVFGPTLLRPQE------ETVAAIMDIKFQNIVVEILIEN 203
RhoGAP_ARHGAP21 cd04395
RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 1-67 3.45e-04

RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction complex. It has been shown to function as a GAP of Cdc42 and RhoA, and to interact with alpha-catenin and Arf6. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239860  Cd Length: 196  Bit Score: 42.77  E-value: 3.45e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 530364531   1 MRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDIeasgfNGTAAFMEVRVQSIVVEFILTHVDQLF 67
Cdd:cd04395  135 IRHLKTVADNSEVNKMEPRNLAIVFGPTLVRTSDD-----NMETMVTHMPDQCKIVETLIQHYDWFF 196
PTZ00121 PTZ00121
MAEBL; Provisional
 502-741 8.60e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.59  E-value: 8.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364531  502 EEQACWEVGEDKQAEpggrlDIREEAEgspETKVEAGKasedrgEAGGSQETKVRLREGSREETEAKEEKSKGQKKADsm 581
Cdd:PTZ00121 1636 EQLKKKEAEEKKKAE-----ELKKAEE---ENKIKAAE------EAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAE-- 1699

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364531  582 EAKGVEEpggdeytdekekeiereedeqREEAQVEAGRDLEQGAQEDQVAEEKWEVVQKQeaegvrEDEDKGQREkgyhE 661
Cdd:PTZ00121 1700 EAKKAEE---------------------LKKKEAEEKKKAEELKKAEEENKIKAEEAKKE------AEEDKKKAE----E 1748

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364531  662 ARKDQGDGEDSRSPEAATEGGAGEVSKERES----GDGEAEGDQRAGGYYLEEDTLS------EGSGVASLEVDCAKEgn 731
Cdd:PTZ00121 1749 AKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAvieeELDEEDEKRRMEVDKKIKDIFDnfaniiEGGKEGNLVINDSKE-- 1826

                         250
                  ....*....|
gi 530364531  732 PHSSEMEEVA 741
Cdd:PTZ00121 1827 MEDSAIKEVA 1836
PRK12678 PRK12678
transcription termination factor Rho; Provisional
 523-705 9.43e-04

transcription termination factor Rho; Provisional


Pssm-ID: 237171 [Multi-domain]  Cd Length: 672  Bit Score: 42.97  E-value: 9.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364531 523 IREEAEGSPETKVEAGKASEDRGEAGGSQETKVRLREGSREETEAKEEKSKGQKKADSMEAKGVEEPGGDEYTDEKEKEI 602
Cdd:PRK12678  55 IKEARGGGAAAAAATPAAPAAAARRAARAAAAARQAEQPAAEAAAAKAEAAPAARAAAAAAAEAASAPEAAQARERRERG 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364531 603 EREEDEQREEAQvEAGRDLEQGAQEDQVAEEKWEVVQKQEAEGVREDEDKGQREKGYHEARKDQGDGEDSRSPEAATEGG 682
Cdd:PRK12678 135 EAARRGAARKAG-EGGEQPATEARADAAERTEEEERDERRRRGDREDRQAEAERGERGRREERGRDGDDRDRRDRREQGD 213

                        170       180
                 ....*....|....*....|...
gi 530364531 683 AGEVSKERESGDGEAEGDQRAGG 705
Cdd:PRK12678 214 RREERGRRDGGDRRGRRRRRDRR 236
PTZ00121 PTZ00121
MAEBL; Provisional
 513-740 9.52e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.21  E-value: 9.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364531  513 KQAEPGGRLD-IREEAEGSPETKVEAGKASEDRG---EAGGSQETKVRLREGSREETEAKEEKSKGQ--KKADSM----E 582
Cdd:PTZ00121 1477 KKAEEAKKADeAKKKAEEAKKKADEAKKAAEAKKkadEAKKAEEAKKADEAKKAEEAKKADEAKKAEekKKADELkkaeE 1556

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364531  583 AKGVEEPGGDEYTDEKEKEIEREEDEQREEAQVEAGRDLEQGAQEDQVAEEKWEVVQKQEAEGVREDE-DKGQREKGYHE 661
Cdd:PTZ00121 1557 LKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEElKKAEEEKKKVE 1636

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530364531  662 ARKDQGDGEDSRSPEAATEGGAGEVSKERESGDGEAEGDQRAGGYYLEEDTLSEGSGVASLEVDCAKEGNPHSSEMEEV 740
Cdd:PTZ00121 1637 QLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEK 1715
PTZ00121 PTZ00121
MAEBL; Provisional
 494-703 1.00e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.21  E-value: 1.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364531  494 RQALGQGGEEQACWEVG---EDKQAEPGGRLDIREEAEGSPETKVEAGKASEDRGEAggsQETKVRLREGSR--EETEAK 568
Cdd:PTZ00121 1268 RQAAIKAEEARKADELKkaeEKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKKKA---EEAKKKADAAKKkaEEAKKA 1344

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364531  569 EEKSKGQKKADSMEAKGVEEPGgdEYTDEKEKEIEREEDEQREEA-QVEAGRDLEQGAQEDQvaeEKWEVVQKQEAEGVR 647
Cdd:PTZ00121 1345 AEAAKAEAEAAADEAEAAEEKA--EAAEKKKEEAKKKADAAKKKAeEKKKADEAKKKAEEDK---KKADELKKAAAAKKK 1419

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 530364531  648 EDEDKGQRE--KGYHEARKdqgDGEDSRSPEAATEggAGEVSKERESGDGEAEGDQRA 703
Cdd:PTZ00121 1420 ADEAKKKAEekKKADEAKK---KAEEAKKADEAKK--KAEEAKKAEEAKKKAEEAKKA 1472
RhoGAP_fRGD1 cd04398
RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 1-67 1.46e-03

RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD1-like proteins. Yeast Rgd1 is a GAP protein for Rho3 and Rho4 and plays a role in low-pH response. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239863  Cd Length: 192  Bit Score: 40.85  E-value: 1.46e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530364531   1 MRHLVHMASFSAQTNMHARNLAIVWAPNLLR--SKDIEASGFngtaafmevrvQSIVVEFILTHVDQLF 67
Cdd:cd04398  135 MFHLARIKEHESVNRMSVNNLAIIWGPTLMNaaPDNAADMSF-----------QSRVIETLLDNAYQIF 192
RhoGAP_ARHGAP6 cd04376
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 16-67 1.62e-03

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239841  Cd Length: 206  Bit Score: 40.89  E-value: 1.62e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 530364531  16 MHARNLAIVWAPNLLRSKDIEASGFNGTAAFMEVRVQSI-VVEFILTHVDQLF 67
Cdd:cd04376  148 MTSLNLATIFGPNLLHKQKSGEREFVQASLRIEESTAIInVVQTMIDNYEELF 200
PTZ00121 PTZ00121
MAEBL; Provisional
 511-691 1.64e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.44  E-value: 1.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364531  511 EDKQAEPGGRLDIREEAEGSPETKVEAGKASEDRGEAGGSQETKVRLREGSREETEAKEEKSKGQ--KKADSMEAKGVEE 588
Cdd:PTZ00121 1364 EKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEekKKADEAKKKAEEA 1443

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364531  589 PGGDEYTDEKEKEIEREEDEQREEAQVEAgRDLEQGAQEDQVAEE---KWEVVQKQ--EAEGVREDEDKGQREKGYHEAR 663
Cdd:PTZ00121 1444 KKADEAKKKAEEAKKAEEAKKKAEEAKKA-DEAKKKAEEAKKADEakkKAEEAKKKadEAKKAAEAKKKADEAKKAEEAK 1522

                         170       180       190
                  ....*....|....*....|....*....|
gi 530364531  664 K--DQGDGEDSRSPEAATEggAGEVSKERE 691
Cdd:PTZ00121 1523 KadEAKKAEEAKKADEAKK--AEEKKKADE 1550
RhoGAP_ARAP cd04385
RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 3-34 1.77e-03

RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity is PIP3-dependent, ARAPs are considered integration points for phosphoinositide, Arf and Rho signaling. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239850  Cd Length: 184  Bit Score: 40.37  E-value: 1.77e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 530364531   3 HLVHMASFSAQTNMHARNLAIVWAPNLLRSKD 34
Cdd:cd04385  133 HLYRVQKHSDENQMSVHNLALVFGPTLFQTDE 164
RhoGAP-p50rhoGAP cd04404
RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 1-67 1.97e-03

RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). It is ubiquitously expressed and preferentially active on Cdc42. This subgroup also contains closely related ARHGAP8. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239869 [Multi-domain]  Cd Length: 195  Bit Score: 40.40  E-value: 1.97e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530364531   1 MRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDIEA--SGFNGTAAFmevrvqsivVEFILTHVDQLF 67
Cdd:cd04404  136 IKFLVQVSAHSDQNKMTNSNLAVVFGPNLLWAKDASMslSAINPINTF---------TKFLLDHQDEIF 195
PTZ00121 PTZ00121
MAEBL; Provisional
 511-703 2.78e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 41.67  E-value: 2.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364531  511 EDKQAEPGGRLDIREEAEGSPETKvEAGKASEDRGEAGGSQETKVRLREGSREETEAK---EEKSKGQKKADsmEAKGVE 587
Cdd:PTZ00121 1514 EAKKAEEAKKADEAKKAEEAKKAD-EAKKAEEKKKADELKKAEELKKAEEKKKAEEAKkaeEDKNMALRKAE--EAKKAE 1590

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364531  588 EPGGDEYTDEKEKEIEREEDEQREEAQV-----------EAGRDLEQGAQEDQVAEEKWEVVQKQEAEG-VREDEDKGQR 655
Cdd:PTZ00121 1591 EARIEEVMKLYEEEKKMKAEEAKKAEEAkikaeelkkaeEEKKKVEQLKKKEAEEKKKAEELKKAEEENkIKAAEEAKKA 1670

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 530364531  656 EKGYHEARKDQGDGEDSRSPEAATEGGAGEVSKERESGDGEAEGDQRA 703
Cdd:PTZ00121 1671 EEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKA 1718
PTZ00121 PTZ00121
MAEBL; Provisional
 511-702 3.27e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 41.67  E-value: 3.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364531  511 EDKQAEPGGRLdiREEAEGSPETKV---EAGKASEDRGEAggsQETKVRLREGSREETEAK--EEKSKGQKKADSMEAKG 585
Cdd:PTZ00121 1455 EAKKAEEAKKK--AEEAKKADEAKKkaeEAKKADEAKKKA---EEAKKKADEAKKAAEAKKkaDEAKKAEEAKKADEAKK 1529

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364531  586 VEEP-GGDEYTDEKEKEIEREEDEQREEAQVEAGRDLEQG-------------AQEDQVAEEK--------WEVVQKQEA 643
Cdd:PTZ00121 1530 AEEAkKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAkkaeedknmalrkAEEAKKAEEArieevmklYEEEKKMKA 1609

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 530364531  644 EGVREDEDKGQREKGYHEARKDQGDGEDSRSPEAATEGGAGEVSKERESGDGEAEGDQR 702
Cdd:PTZ00121 1610 EEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAK 1668
PTZ00121 PTZ00121
MAEBL; Provisional
 525-678 5.66e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.89  E-value: 5.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364531  525 EEAEGSPETKVEAGKASEDRGEAGGSQETKVRLREGSREETEAKeeKSKGQKKADSMEAKGVEEPGGDEYTDEKEKEIER 604
Cdd:PTZ00121 1421 DEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKK--KAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKK 1498

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530364531  605 EEDEQREEAQVEAGRDLEQgAQEDQVAEEKWEVVQKQEAEGVREDEDKGQRE--KGYHEARKdqgdGEDSRSPEAA 678
Cdd:PTZ00121 1499 ADEAKKAAEAKKKADEAKK-AEEAKKADEAKKAEEAKKADEAKKAEEKKKADelKKAEELKK----AEEKKKAEEA 1569
RhoGAP_ARHGAP27_15_12_9 cd04403
RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 2-61 7.74e-03

RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are studied show GAP activity towards Rac1, some additionally show activity towards Cdc42. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239868 [Multi-domain]  Cd Length: 187  Bit Score: 38.53  E-value: 7.74e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364531   2 RHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDiEASGFNGTAAFmevrvQSIVVEFILT 61
Cdd:cd04403  133 RHLCRVIEHGEKNRMTTQNLAIVFGPTLLRPEQ-ETGNIAVHMVY-----QNQIVELILL 186
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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