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Conserved domains on  [gi|530370023|ref|XP_005246453|]
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DNA-binding protein SATB2 isoform X2 [Homo sapiens]

Protein Classification

SATB1_N and CUTL domain-containing protein( domain architecture ID 11243844)

protein containing domains SATB1_N, CUTL, CUT, and homeodomain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ULD pfam16534
Ubiquitin-like oligomerization domain of SATB; ULD is an N-terminal oligomerization domain of ...
 1-98 4.69e-52

Ubiquitin-like oligomerization domain of SATB; ULD is an N-terminal oligomerization domain of SATB or special AT-rich sequence-binding proteins. SATBs are global chromatin organizers and regulators of gene expression that are essential for T-cell development, breast cancer tumour growth and metastasis. SATBs assemble into a tetramer via the ULD domain, and the tetramerization of SATBs are essential for recognising specific DNA sequences (such as multiple AT-rich DNA fragments). Thus, SATBs may regulate gene expression directly by binding to various promoters and upstream regions and thereby influencing promoter activity.


:

Pssm-ID: 465165  Cd Length: 105  Bit Score: 174.84  E-value: 4.69e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530370023    1 MIPVFCVVEQLDGSLEYDNRE------EHAEFVLVRKDVLFSQLVETALLALGYSHSSAAQAQGIIKLGRWNPLPLSYVT 74
Cdd:pfam16534   2 SLPVHCVVEQVESLQESNECDertpnvEHDSYVIIPKDTLFSDLVETALLRLGYSHSSAAQAKGSIQIKNWKPLSLESIT 81

                          90       100
                  ....*....|....*....|....
gi 530370023   75 DAPDATVADMLQDVYHVVTLKIQL 98
Cdd:pfam16534  82 DDPDATVGDMLGDLTTVATLRIQL 105
CUTL pfam16557
CUT1-like DNA-binding domain of SATB; CUTL is part of the N-terminal region of SATB proteins, ...
 104-175 2.33e-40

CUT1-like DNA-binding domain of SATB; CUTL is part of the N-terminal region of SATB proteins, special AT-rich sequence-binding proteins that are global chromatin organizers and gene expression regulators essential for T-cell development and breast cancer tumour growth and metastasis. CUTL carries a DNA-binding region just as CUT domains do.


:

Pssm-ID: 435427  Cd Length: 72  Bit Score: 141.99  E-value: 2.33e-40
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530370023  104 LEDLPAEQWNHATVRNALKELLKEMNQSTLAKECPLSQSMISSIVNSTYYANVSATKCQEFGRWYKKYKKIK 175
Cdd:pfam16557   1 PELLPPDKWTDQTVRCAVKELLKEMLQSTLAKLCPLTQSMISSIVNSTYYANVSADKCQEFGRWYKQYKKIK 72
CUT pfam02376
CUT domain; The CUT domain is a DNA-binding motif which can bind independently or in ...
 419-498 1.03e-21

CUT domain; The CUT domain is a DNA-binding motif which can bind independently or in cooperation with the homeodomain, often found downstream of the CUT domain. Multiple copies of the CUT domain can exist in one protein.


:

Pssm-ID: 460543  Cd Length: 78  Bit Score: 89.19  E-value: 1.03e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530370023  419 DGANINiTAAIYDEIQQEMKRAKVSQALFAKVAANKSQGWLCELLRwkeNPSPenrtlWENLCT-------IRRFLNLPQ 491
Cdd:pfam02376   1 DSEELD-TKDIADRIKEELKRHKISQAVFAEKVLNRSQGTLSDLLR---KPKP-----WEKLKSggrtfirMYNWLSLPE 71


                  ....*..
gi 530370023  492 HERDVIY 498
Cdd:pfam02376  72 DERMEIL 78
CUT pfam02376
CUT domain; The CUT domain is a DNA-binding motif which can bind independently or in ...
 297-375 4.10e-19

CUT domain; The CUT domain is a DNA-binding motif which can bind independently or in cooperation with the homeodomain, often found downstream of the CUT domain. Multiple copies of the CUT domain can exist in one protein.


:

Pssm-ID: 460543  Cd Length: 78  Bit Score: 81.87  E-value: 4.10e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530370023  297 NSSVEVSPDIYQQVRDELKRASVSQAVFARVAFNRTQGLLSEILRKeedPRTASQSLLV--NLRAMQNFLNLPEVERDRI 374
Cdd:pfam02376   1 DSEELDTKDIADRIKEELKRHKISQAVFAEKVLNRSQGTLSDLLRK---PKPWEKLKSGgrTFIRMYNWLSLPEDERMEI 77


                  .
gi 530370023  375 Y 375
Cdd:pfam02376  78 L 78
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 556-613 1.41e-07

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


:

Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 48.40  E-value: 1.41e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 530370023   556 KPRSRTKISLEALGILQSFIHDvGLYPDQEAIHTLSAQLDLPKHTIIKFFQNQRYHVK 613
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQK-NPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
 
Name Accession Description Interval E-value
ULD pfam16534
Ubiquitin-like oligomerization domain of SATB; ULD is an N-terminal oligomerization domain of ...
 1-98 4.69e-52

Ubiquitin-like oligomerization domain of SATB; ULD is an N-terminal oligomerization domain of SATB or special AT-rich sequence-binding proteins. SATBs are global chromatin organizers and regulators of gene expression that are essential for T-cell development, breast cancer tumour growth and metastasis. SATBs assemble into a tetramer via the ULD domain, and the tetramerization of SATBs are essential for recognising specific DNA sequences (such as multiple AT-rich DNA fragments). Thus, SATBs may regulate gene expression directly by binding to various promoters and upstream regions and thereby influencing promoter activity.


Pssm-ID: 465165  Cd Length: 105  Bit Score: 174.84  E-value: 4.69e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530370023    1 MIPVFCVVEQLDGSLEYDNRE------EHAEFVLVRKDVLFSQLVETALLALGYSHSSAAQAQGIIKLGRWNPLPLSYVT 74
Cdd:pfam16534   2 SLPVHCVVEQVESLQESNECDertpnvEHDSYVIIPKDTLFSDLVETALLRLGYSHSSAAQAKGSIQIKNWKPLSLESIT 81

                          90       100
                  ....*....|....*....|....
gi 530370023   75 DAPDATVADMLQDVYHVVTLKIQL 98
Cdd:pfam16534  82 DDPDATVGDMLGDLTTVATLRIQL 105
SATB1_N cd11585
N-terminal domain of SATB1 and similar proteins; SATB1, the special AT-rich sequence-binding ...
 2-97 2.47e-50

N-terminal domain of SATB1 and similar proteins; SATB1, the special AT-rich sequence-binding protein 1, is involved in organizing chromosomal loci into distinct loops, creating a "loopscape" that has a direct bearing on gene expression. This N-terminal domain, which may be involved in various interactions with chromatin proteins, resembles a ubiquitin domain and has been shown to form tetramers, a function critical to SATB1-DNA interactions. The related Drosophila homeobox gene defective proventriculus (dve) plays a key role in the functional specification during endoderm development.


Pssm-ID: 211426  Cd Length: 100  Bit Score: 170.20  E-value: 2.47e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530370023   2 IPVFCVVEQLDGSLE----YDNREEHAEFVLVRKDVLFSQLVETALLALGYSHSSAAQAQGIIKLGRWNPLPLSYVTDAP 77
Cdd:cd11585    1 LPVHCVVETVDSLHEsvwrRRPRVETDSYVIIPKDTLFNQLVETALLRLGYSHSSAASAKGLIQIKNWKPLPFDQITDNP 80

                         90       100
                 ....*....|....*....|
gi 530370023  78 DATVADMLQDVYHVVTLKIQ 97
Cdd:cd11585   81 DATVGDMLGELTHVATLRIQ 100
CUTL pfam16557
CUT1-like DNA-binding domain of SATB; CUTL is part of the N-terminal region of SATB proteins, ...
 104-175 2.33e-40

CUT1-like DNA-binding domain of SATB; CUTL is part of the N-terminal region of SATB proteins, special AT-rich sequence-binding proteins that are global chromatin organizers and gene expression regulators essential for T-cell development and breast cancer tumour growth and metastasis. CUTL carries a DNA-binding region just as CUT domains do.


Pssm-ID: 435427  Cd Length: 72  Bit Score: 141.99  E-value: 2.33e-40
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530370023  104 LEDLPAEQWNHATVRNALKELLKEMNQSTLAKECPLSQSMISSIVNSTYYANVSATKCQEFGRWYKKYKKIK 175
Cdd:pfam16557   1 PELLPPDKWTDQTVRCAVKELLKEMLQSTLAKLCPLTQSMISSIVNSTYYANVSADKCQEFGRWYKQYKKIK 72
CUT pfam02376
CUT domain; The CUT domain is a DNA-binding motif which can bind independently or in ...
 419-498 1.03e-21

CUT domain; The CUT domain is a DNA-binding motif which can bind independently or in cooperation with the homeodomain, often found downstream of the CUT domain. Multiple copies of the CUT domain can exist in one protein.


Pssm-ID: 460543  Cd Length: 78  Bit Score: 89.19  E-value: 1.03e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530370023  419 DGANINiTAAIYDEIQQEMKRAKVSQALFAKVAANKSQGWLCELLRwkeNPSPenrtlWENLCT-------IRRFLNLPQ 491
Cdd:pfam02376   1 DSEELD-TKDIADRIKEELKRHKISQAVFAEKVLNRSQGTLSDLLR---KPKP-----WEKLKSggrtfirMYNWLSLPE 71


                  ....*..
gi 530370023  492 HERDVIY 498
Cdd:pfam02376  72 DERMEIL 78
CUT pfam02376
CUT domain; The CUT domain is a DNA-binding motif which can bind independently or in ...
 297-375 4.10e-19

CUT domain; The CUT domain is a DNA-binding motif which can bind independently or in cooperation with the homeodomain, often found downstream of the CUT domain. Multiple copies of the CUT domain can exist in one protein.


Pssm-ID: 460543  Cd Length: 78  Bit Score: 81.87  E-value: 4.10e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530370023  297 NSSVEVSPDIYQQVRDELKRASVSQAVFARVAFNRTQGLLSEILRKeedPRTASQSLLV--NLRAMQNFLNLPEVERDRI 374
Cdd:pfam02376   1 DSEELDTKDIADRIKEELKRHKISQAVFAEKVLNRSQGTLSDLLRK---PKPWEKLKSGgrTFIRMYNWLSLPEDERMEI 77


                  .
gi 530370023  375 Y 375
Cdd:pfam02376  78 L 78
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 556-613 1.41e-07

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 48.40  E-value: 1.41e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 530370023   556 KPRSRTKISLEALGILQSFIHDvGLYPDQEAIHTLSAQLDLPKHTIIKFFQNQRYHVK 613
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQK-NPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 557-615 1.01e-05

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 43.39  E-value: 1.01e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 530370023 557 PRSRTKISLEALGILQSFIHDVGlYPDQEAIHTLSAQLDLPKHTIIKFFQNQRYHVKHH 615
Cdd:cd00086    1 RRKRTRFTPEQLEELEKEFEKNP-YPSREEREELAKELGLTERQVKIWFQNRRAKLKRS 58
 
Name Accession Description Interval E-value
ULD pfam16534
Ubiquitin-like oligomerization domain of SATB; ULD is an N-terminal oligomerization domain of ...
 1-98 4.69e-52

Ubiquitin-like oligomerization domain of SATB; ULD is an N-terminal oligomerization domain of SATB or special AT-rich sequence-binding proteins. SATBs are global chromatin organizers and regulators of gene expression that are essential for T-cell development, breast cancer tumour growth and metastasis. SATBs assemble into a tetramer via the ULD domain, and the tetramerization of SATBs are essential for recognising specific DNA sequences (such as multiple AT-rich DNA fragments). Thus, SATBs may regulate gene expression directly by binding to various promoters and upstream regions and thereby influencing promoter activity.


Pssm-ID: 465165  Cd Length: 105  Bit Score: 174.84  E-value: 4.69e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530370023    1 MIPVFCVVEQLDGSLEYDNRE------EHAEFVLVRKDVLFSQLVETALLALGYSHSSAAQAQGIIKLGRWNPLPLSYVT 74
Cdd:pfam16534   2 SLPVHCVVEQVESLQESNECDertpnvEHDSYVIIPKDTLFSDLVETALLRLGYSHSSAAQAKGSIQIKNWKPLSLESIT 81

                          90       100
                  ....*....|....*....|....
gi 530370023   75 DAPDATVADMLQDVYHVVTLKIQL 98
Cdd:pfam16534  82 DDPDATVGDMLGDLTTVATLRIQL 105
SATB1_N cd11585
N-terminal domain of SATB1 and similar proteins; SATB1, the special AT-rich sequence-binding ...
 2-97 2.47e-50

N-terminal domain of SATB1 and similar proteins; SATB1, the special AT-rich sequence-binding protein 1, is involved in organizing chromosomal loci into distinct loops, creating a "loopscape" that has a direct bearing on gene expression. This N-terminal domain, which may be involved in various interactions with chromatin proteins, resembles a ubiquitin domain and has been shown to form tetramers, a function critical to SATB1-DNA interactions. The related Drosophila homeobox gene defective proventriculus (dve) plays a key role in the functional specification during endoderm development.


Pssm-ID: 211426  Cd Length: 100  Bit Score: 170.20  E-value: 2.47e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530370023   2 IPVFCVVEQLDGSLE----YDNREEHAEFVLVRKDVLFSQLVETALLALGYSHSSAAQAQGIIKLGRWNPLPLSYVTDAP 77
Cdd:cd11585    1 LPVHCVVETVDSLHEsvwrRRPRVETDSYVIIPKDTLFNQLVETALLRLGYSHSSAASAKGLIQIKNWKPLPFDQITDNP 80

                         90       100
                 ....*....|....*....|
gi 530370023  78 DATVADMLQDVYHVVTLKIQ 97
Cdd:cd11585   81 DATVGDMLGELTHVATLRIQ 100
CUTL pfam16557
CUT1-like DNA-binding domain of SATB; CUTL is part of the N-terminal region of SATB proteins, ...
 104-175 2.33e-40

CUT1-like DNA-binding domain of SATB; CUTL is part of the N-terminal region of SATB proteins, special AT-rich sequence-binding proteins that are global chromatin organizers and gene expression regulators essential for T-cell development and breast cancer tumour growth and metastasis. CUTL carries a DNA-binding region just as CUT domains do.


Pssm-ID: 435427  Cd Length: 72  Bit Score: 141.99  E-value: 2.33e-40
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530370023  104 LEDLPAEQWNHATVRNALKELLKEMNQSTLAKECPLSQSMISSIVNSTYYANVSATKCQEFGRWYKKYKKIK 175
Cdd:pfam16557   1 PELLPPDKWTDQTVRCAVKELLKEMLQSTLAKLCPLTQSMISSIVNSTYYANVSADKCQEFGRWYKQYKKIK 72
CUT pfam02376
CUT domain; The CUT domain is a DNA-binding motif which can bind independently or in ...
 419-498 1.03e-21

CUT domain; The CUT domain is a DNA-binding motif which can bind independently or in cooperation with the homeodomain, often found downstream of the CUT domain. Multiple copies of the CUT domain can exist in one protein.


Pssm-ID: 460543  Cd Length: 78  Bit Score: 89.19  E-value: 1.03e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530370023  419 DGANINiTAAIYDEIQQEMKRAKVSQALFAKVAANKSQGWLCELLRwkeNPSPenrtlWENLCT-------IRRFLNLPQ 491
Cdd:pfam02376   1 DSEELD-TKDIADRIKEELKRHKISQAVFAEKVLNRSQGTLSDLLR---KPKP-----WEKLKSggrtfirMYNWLSLPE 71


                  ....*..
gi 530370023  492 HERDVIY 498
Cdd:pfam02376  72 DERMEIL 78
CUT pfam02376
CUT domain; The CUT domain is a DNA-binding motif which can bind independently or in ...
 297-375 4.10e-19

CUT domain; The CUT domain is a DNA-binding motif which can bind independently or in cooperation with the homeodomain, often found downstream of the CUT domain. Multiple copies of the CUT domain can exist in one protein.


Pssm-ID: 460543  Cd Length: 78  Bit Score: 81.87  E-value: 4.10e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530370023  297 NSSVEVSPDIYQQVRDELKRASVSQAVFARVAFNRTQGLLSEILRKeedPRTASQSLLV--NLRAMQNFLNLPEVERDRI 374
Cdd:pfam02376   1 DSEELDTKDIADRIKEELKRHKISQAVFAEKVLNRSQGTLSDLLRK---PKPWEKLKSGgrTFIRMYNWLSLPEDERMEI 77


                  .
gi 530370023  375 Y 375
Cdd:pfam02376  78 L 78
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 556-613 1.41e-07

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 48.40  E-value: 1.41e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 530370023   556 KPRSRTKISLEALGILQSFIHDvGLYPDQEAIHTLSAQLDLPKHTIIKFFQNQRYHVK 613
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQK-NPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 557-615 1.01e-05

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 43.39  E-value: 1.01e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 530370023 557 PRSRTKISLEALGILQSFIHDVGlYPDQEAIHTLSAQLDLPKHTIIKFFQNQRYHVKHH 615
Cdd:cd00086    1 RRKRTRFTPEQLEELEKEFEKNP-YPSREEREELAKELGLTERQVKIWFQNRRAKLKRS 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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