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Conserved domains on  [gi|530379292|ref|XP_005248558|]
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transportin-1 isoform X2 [Homo sapiens]

Protein Classification

importin beta family protein( domain architecture ID 707677)

importin beta family protein may function in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KAP95 super family cl27231
Karyopherin (importin) beta [Intracellular trafficking and secretion];
32-741 3.91e-25

Karyopherin (importin) beta [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5215:

Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 112.34  E-value: 3.91e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379292  32 SPDTTIQRTVQQKLEQLnQYPDFNNY---LIFVLTKLKSEDEpTRSLSGLILKNNVKAH-----------FQNFPNGVTD 97
Cdd:COG5215   16 SPDPNARLRAEAQLLEL-QSGDFEQFislLVQVLCDLNSNDQ-LRMVAGLILKNSLHANdpelqkgcsqrWLGMRHESKE 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379292  98 FIKSECLNNIGDSSPLIRATVGILITTIASKgELQN--WPDLLPKLCSLL-DSEDYNTCEGAFGALQKICEDSaeilDSD 174
Cdd:COG5215   94 QVKGMALRALKSPEPRFCTMAAQLLAAIARM-ELPNslWPGLMEEMVRNVgDEQPVSGKCESLGICGYHCESE----APE 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379292 175 VLDRPLNIMIPKFLQFFKHSSPKIRShavacvnqfiisRTQALMLHIDS--FIENLFALAGD--------------EEPE 238
Cdd:COG5215  169 DLIQMSNVILFAIVMGALKNETTSAV------------RLAALKALMDSlmFVQGNFCYEEErnyfmqvvceatqgNDEE 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379292 239 VRKNVCRALVMLLEVRMDRLLPHMHN-IVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDVLVRHLPKLIPVLVNGMK 317
Cdd:COG5215  237 LQHAAFGCLNKIMMLYYKFMQSYMENaLAALTGRFMKSQNDEVAIQAVEFWSTICEEEIDGEMEDKYLPEVPAQNHGFAR 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379292 318 YSDIDII--LLKGDVEEDetiPDSEQDirprfhrsrtvaqqhdedgieeedddddeiddddtisDWNLRKCSAAALDVLA 395
Cdd:COG5215  317 AAVADVLpeLLSLLEKQG---EDYYGD-------------------------------------DWNPSMAASSCLQLFA 356

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379292 396 NVYRDELLPHILPLLKELLFHHEWVVKESGILVLGAIAEG-CMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRYA 474
Cdd:COG5215  357 QLKGDKIMRPVLGFVEQNIRSESWANREAAVMAFGSVMHGpCEDCLTKIVPQALPGIENEMSDSCLWVKSTTAWCFGAIA 436

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379292 475 -HWVVSQPPDTYLKPLMTELLKRILDSNKRVqeAACS--------AFATLEEEACTELVPYLAYILDTLVFAFSKYQHKN 545
Cdd:COG5215  437 dHVAMIISPCGHLVLEVSASLIGLMDCPFRS--INCSwrkenlvdHIAKAVREVESFLAKFYLAILNALVKGTELALNES 514

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379292 546 LL--ILYDAIGTL----ADSVGHHL-NKPEYIQMLMPPLIQ-KWNMLKDEDKDLF-PLLECLSSVATALQSGFLPYCEPV 616
Cdd:COG5215  515 NLrvSLFSALGTLilicPDAVSDILaGFYDYTSKKLDECISvLGQILATEDQLLVeELQSNYIGVLEAIIRTRRRDIEDV 594

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379292 617 YQRCVNLVQKTLAQAMLNNAQPDQYEApdkdfmivaldlLSGLAEGLGGNIEQLVarSNILTLMYQCMQDKMPEVRQSSF 696
Cdd:COG5215  595 EDQLMELFIRILESTKPTTAFGDVYTA------------ISALSTSLEERFEQYA--SKFIPYLTRALNCTDRFVLNSAV 660

                        730       740       750       760       770
                 ....*....|....*....|....*....|....*....|....*....|....
gi 530379292 697 ALLGDLTKACFQHVKPCIADFM---------PILGTNLNPEFISVCNNATWAIG 741
Cdd:COG5215  661 GLVGDLANTLGTDFNIYADVLMsslvqclssEATHRDLKPAILSVFGDIALAIG 714
 
Name Accession Description Interval E-value
KAP95 COG5215
Karyopherin (importin) beta [Intracellular trafficking and secretion];
32-741 3.91e-25

Karyopherin (importin) beta [Intracellular trafficking and secretion];


Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 112.34  E-value: 3.91e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379292  32 SPDTTIQRTVQQKLEQLnQYPDFNNY---LIFVLTKLKSEDEpTRSLSGLILKNNVKAH-----------FQNFPNGVTD 97
Cdd:COG5215   16 SPDPNARLRAEAQLLEL-QSGDFEQFislLVQVLCDLNSNDQ-LRMVAGLILKNSLHANdpelqkgcsqrWLGMRHESKE 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379292  98 FIKSECLNNIGDSSPLIRATVGILITTIASKgELQN--WPDLLPKLCSLL-DSEDYNTCEGAFGALQKICEDSaeilDSD 174
Cdd:COG5215   94 QVKGMALRALKSPEPRFCTMAAQLLAAIARM-ELPNslWPGLMEEMVRNVgDEQPVSGKCESLGICGYHCESE----APE 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379292 175 VLDRPLNIMIPKFLQFFKHSSPKIRShavacvnqfiisRTQALMLHIDS--FIENLFALAGD--------------EEPE 238
Cdd:COG5215  169 DLIQMSNVILFAIVMGALKNETTSAV------------RLAALKALMDSlmFVQGNFCYEEErnyfmqvvceatqgNDEE 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379292 239 VRKNVCRALVMLLEVRMDRLLPHMHN-IVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDVLVRHLPKLIPVLVNGMK 317
Cdd:COG5215  237 LQHAAFGCLNKIMMLYYKFMQSYMENaLAALTGRFMKSQNDEVAIQAVEFWSTICEEEIDGEMEDKYLPEVPAQNHGFAR 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379292 318 YSDIDII--LLKGDVEEDetiPDSEQDirprfhrsrtvaqqhdedgieeedddddeiddddtisDWNLRKCSAAALDVLA 395
Cdd:COG5215  317 AAVADVLpeLLSLLEKQG---EDYYGD-------------------------------------DWNPSMAASSCLQLFA 356

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379292 396 NVYRDELLPHILPLLKELLFHHEWVVKESGILVLGAIAEG-CMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRYA 474
Cdd:COG5215  357 QLKGDKIMRPVLGFVEQNIRSESWANREAAVMAFGSVMHGpCEDCLTKIVPQALPGIENEMSDSCLWVKSTTAWCFGAIA 436

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379292 475 -HWVVSQPPDTYLKPLMTELLKRILDSNKRVqeAACS--------AFATLEEEACTELVPYLAYILDTLVFAFSKYQHKN 545
Cdd:COG5215  437 dHVAMIISPCGHLVLEVSASLIGLMDCPFRS--INCSwrkenlvdHIAKAVREVESFLAKFYLAILNALVKGTELALNES 514

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379292 546 LL--ILYDAIGTL----ADSVGHHL-NKPEYIQMLMPPLIQ-KWNMLKDEDKDLF-PLLECLSSVATALQSGFLPYCEPV 616
Cdd:COG5215  515 NLrvSLFSALGTLilicPDAVSDILaGFYDYTSKKLDECISvLGQILATEDQLLVeELQSNYIGVLEAIIRTRRRDIEDV 594

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379292 617 YQRCVNLVQKTLAQAMLNNAQPDQYEApdkdfmivaldlLSGLAEGLGGNIEQLVarSNILTLMYQCMQDKMPEVRQSSF 696
Cdd:COG5215  595 EDQLMELFIRILESTKPTTAFGDVYTA------------ISALSTSLEERFEQYA--SKFIPYLTRALNCTDRFVLNSAV 660

                        730       740       750       760       770
                 ....*....|....*....|....*....|....*....|....*....|....
gi 530379292 697 ALLGDLTKACFQHVKPCIADFM---------PILGTNLNPEFISVCNNATWAIG 741
Cdd:COG5215  661 GLVGDLANTLGTDFNIYADVLMsslvqclssEATHRDLKPAILSVFGDIALAIG 714
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 419-473 3.38e-14

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 67.39  E-value: 3.38e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 530379292  419 WVVKESGILVLGAIAEGCMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRY 473
Cdd:pfam13513   1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
IBN_N smart00913
Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can ...
 42-109 1.68e-07

Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can bind and transport cargo by themselves, or can form heterodimers with importin-alpha. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Importin-beta is a helicoidal molecule constructed from 19 HEAT repeats. Many nuclear pore proteins contain FG sequence repeats that can bind to HEAT repeats within importins.. which is important for importin-beta mediated transport.


Pssm-ID: 197981 [Multi-domain]  Cd Length: 67  Bit Score: 48.78  E-value: 1.68e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530379292    42 QQKLEQLNQYPDFNNYLIFVLTKlkSEDEPTRSLSGLILKNNVKAHFQNFPNGVTDFIKSECLNNIGD 109
Cdd:smart00913   2 EKQLEQFQKSPGFWLLLLEILAN--SEDQYVRQLAAITLKNKITRRWSSLPEEEKEEIKNSLLELLLS 67
 
Name Accession Description Interval E-value
KAP95 COG5215
Karyopherin (importin) beta [Intracellular trafficking and secretion];
32-741 3.91e-25

Karyopherin (importin) beta [Intracellular trafficking and secretion];


Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 112.34  E-value: 3.91e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379292  32 SPDTTIQRTVQQKLEQLnQYPDFNNY---LIFVLTKLKSEDEpTRSLSGLILKNNVKAH-----------FQNFPNGVTD 97
Cdd:COG5215   16 SPDPNARLRAEAQLLEL-QSGDFEQFislLVQVLCDLNSNDQ-LRMVAGLILKNSLHANdpelqkgcsqrWLGMRHESKE 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379292  98 FIKSECLNNIGDSSPLIRATVGILITTIASKgELQN--WPDLLPKLCSLL-DSEDYNTCEGAFGALQKICEDSaeilDSD 174
Cdd:COG5215   94 QVKGMALRALKSPEPRFCTMAAQLLAAIARM-ELPNslWPGLMEEMVRNVgDEQPVSGKCESLGICGYHCESE----APE 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379292 175 VLDRPLNIMIPKFLQFFKHSSPKIRShavacvnqfiisRTQALMLHIDS--FIENLFALAGD--------------EEPE 238
Cdd:COG5215  169 DLIQMSNVILFAIVMGALKNETTSAV------------RLAALKALMDSlmFVQGNFCYEEErnyfmqvvceatqgNDEE 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379292 239 VRKNVCRALVMLLEVRMDRLLPHMHN-IVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDVLVRHLPKLIPVLVNGMK 317
Cdd:COG5215  237 LQHAAFGCLNKIMMLYYKFMQSYMENaLAALTGRFMKSQNDEVAIQAVEFWSTICEEEIDGEMEDKYLPEVPAQNHGFAR 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379292 318 YSDIDII--LLKGDVEEDetiPDSEQDirprfhrsrtvaqqhdedgieeedddddeiddddtisDWNLRKCSAAALDVLA 395
Cdd:COG5215  317 AAVADVLpeLLSLLEKQG---EDYYGD-------------------------------------DWNPSMAASSCLQLFA 356

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379292 396 NVYRDELLPHILPLLKELLFHHEWVVKESGILVLGAIAEG-CMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRYA 474
Cdd:COG5215  357 QLKGDKIMRPVLGFVEQNIRSESWANREAAVMAFGSVMHGpCEDCLTKIVPQALPGIENEMSDSCLWVKSTTAWCFGAIA 436

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379292 475 -HWVVSQPPDTYLKPLMTELLKRILDSNKRVqeAACS--------AFATLEEEACTELVPYLAYILDTLVFAFSKYQHKN 545
Cdd:COG5215  437 dHVAMIISPCGHLVLEVSASLIGLMDCPFRS--INCSwrkenlvdHIAKAVREVESFLAKFYLAILNALVKGTELALNES 514

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379292 546 LL--ILYDAIGTL----ADSVGHHL-NKPEYIQMLMPPLIQ-KWNMLKDEDKDLF-PLLECLSSVATALQSGFLPYCEPV 616
Cdd:COG5215  515 NLrvSLFSALGTLilicPDAVSDILaGFYDYTSKKLDECISvLGQILATEDQLLVeELQSNYIGVLEAIIRTRRRDIEDV 594

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379292 617 YQRCVNLVQKTLAQAMLNNAQPDQYEApdkdfmivaldlLSGLAEGLGGNIEQLVarSNILTLMYQCMQDKMPEVRQSSF 696
Cdd:COG5215  595 EDQLMELFIRILESTKPTTAFGDVYTA------------ISALSTSLEERFEQYA--SKFIPYLTRALNCTDRFVLNSAV 660

                        730       740       750       760       770
                 ....*....|....*....|....*....|....*....|....*....|....
gi 530379292 697 ALLGDLTKACFQHVKPCIADFM---------PILGTNLNPEFISVCNNATWAIG 741
Cdd:COG5215  661 GLVGDLANTLGTDFNIYADVLMsslvqclssEATHRDLKPAILSVFGDIALAIG 714
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 419-473 3.38e-14

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 67.39  E-value: 3.38e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 530379292  419 WVVKESGILVLGAIAEGCMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRY 473
Cdd:pfam13513   1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
IBN_N pfam03810
Importin-beta N-terminal domain;
42-109 7.98e-11

Importin-beta N-terminal domain;


Pssm-ID: 397745 [Multi-domain]  Cd Length: 72  Bit Score: 58.40  E-value: 7.98e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530379292   42 QQKLEQLNQYPDFNNYLIFVLTKLKSeDEPTRSLSGLILKNNVKAHFQ----NFPNGVTDFIKSECLNNIGD 109
Cdd:pfam03810   2 EKQLEQFEKSPGFWSKLLQILSNSEN-PLEVRQLAALYLKNLITRHWEeeknSLPPEEKEQIKNNLLNLLGS 72
CSE1 COG5657
CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning]; ...
 31-196 1.20e-08

CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning];


Pssm-ID: 227944 [Multi-domain]  Cd Length: 947  Bit Score: 59.06  E-value: 1.20e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379292  31 QSPDTTIQRTVQQKLEQLNQYPDFNnYLIFVLTKLKSEDEPTRSLSGLILKNNVKAHF-QNFPNGV----TDFIKSECLN 105
Cdd:COG5657   14 QSPDPPSVKCAEERLRQWEKQHGFA-LKLLSINLSAFNSMSLRWAALIQFKNYIDKHWrEENGNSIlpdeNVLIRDELFS 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379292 106 NIGDSSPLIRATVGILITTIASKGELQNWPDLLPKLCSLLDSEDYNTCEGAFGALQKICEDSAEILDSDVLDRPLNIMIP 185
Cdd:COG5657   93 LIISSSNQLQIQNALAVSRIARLDFPDEWPTLVPDLLSLLSEKDMVTNENSLRVLHHIFKRLRRLFRSDALFLEIAPVLL 172

                        170
                 ....*....|.
gi 530379292 186 KFLQFFKHSSP 196
Cdd:COG5657  173 SILCPFLFSSA 183
IBN_N smart00913
Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can ...
 42-109 1.68e-07

Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can bind and transport cargo by themselves, or can form heterodimers with importin-alpha. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Importin-beta is a helicoidal molecule constructed from 19 HEAT repeats. Many nuclear pore proteins contain FG sequence repeats that can bind to HEAT repeats within importins.. which is important for importin-beta mediated transport.


Pssm-ID: 197981 [Multi-domain]  Cd Length: 67  Bit Score: 48.78  E-value: 1.68e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530379292    42 QQKLEQLNQYPDFNNYLIFVLTKlkSEDEPTRSLSGLILKNNVKAHFQNFPNGVTDFIKSECLNNIGD 109
Cdd:smart00913   2 EKQLEQFQKSPGFWLLLLEILAN--SEDQYVRQLAAITLKNKITRRWSSLPEEEKEEIKNSLLELLLS 67
HEAT COG1413
HEAT repeat [General function prediction only];
388-532 1.62e-06

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 48.09  E-value: 1.62e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379292 388 AAALDVLANVYRDEllphILPLLKELLFHHEWVVKESGILVLGAIAEgcmqgmipylPELIPHLIQCLSDKKALVRSITC 467
Cdd:COG1413    3 RAAARALGRLGDPA----AVPALIAALADEDPDVRAAAARALGRLGD----------PRAVPALLEALKDPDPEVRAAAA 68

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 530379292 468 WTLSRYAHWVVSqppdtylkPLMTELLKrilDSNKRVQEAACSAFATLEEEactELVPYLAYILD 532
Cdd:COG1413   69 EALGRIGDPEAV--------PALIAALK---DEDPEVRRAAAEALGRLGDP---AAVPALLEALK 119
HEAT COG1413
HEAT repeat [General function prediction only];
129-286 2.67e-06

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 47.70  E-value: 2.67e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379292 129 GELQNwPDLLPKLCSLLDSEDYNTCEGAFGALQKICEDSAeildsdvldrplnimIPKFLQFFKHSSPKIRSHAVACVNQ 208
Cdd:COG1413   10 GRLGD-PAAVPALIAALADEDPDVRAAAARALGRLGDPRA---------------VPALLEALKDPDPEVRAAAAEALGR 73

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530379292 209 fiISRTQAlmlhidsfIENLFALAGDEEPEVRKNVCRALVMLLEVRmdrllphmhnIVEYMLQRTQDQDENVALEACE 286
Cdd:COG1413   74 --IGDPEA--------VPALIAALKDEDPEVRRAAAEALGRLGDPA----------AVPALLEALKDPDWEVRRAAAR 131
HEAT COG1413
HEAT repeat [General function prediction only];
379-515 1.37e-05

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 45.39  E-value: 1.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379292 379 SDWNLRkcsAAALDVLANVYRDEllphILPLLKELLFHHEWVVKESGILVLGAIAEgcmqgmipylPELIPHLIQCLSDK 458
Cdd:COG1413   28 EDPDVR---AAAARALGRLGDPR----AVPALLEALKDPDPEVRAAAAEALGRIGD----------PEAVPALIAALKDE 90

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 530379292 459 KALVRSITCWTLSRYAhwvvsqppDTYLKPLMTELLKrilDSNKRVQEAACSAFATL 515
Cdd:COG1413   91 DPEVRRAAAEALGRLG--------DPAAVPALLEALK---DPDWEVRRAAARALGRL 136
HEAT COG1413
HEAT repeat [General function prediction only];
379-474 2.03e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 42.31  E-value: 2.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379292 379 SDWNLRkcsAAALDVLANVYRDEllphILPLLKELLFHHEWVVKESGILVLGAIAEgcmqgmipylPELIPHLIQCLSDK 458
Cdd:COG1413   59 PDPEVR---AAAAEALGRIGDPE----AVPALIAALKDEDPEVRRAAAEALGRLGD----------PAAVPALLEALKDP 121

                         90
                 ....*....|....*.
gi 530379292 459 KALVRSITCWTLSRYA 474
Cdd:COG1413  122 DWEVRRAAARALGRLG 137
HEAT COG1413
HEAT repeat [General function prediction only];
421-591 1.44e-03

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 39.61  E-value: 1.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379292 421 VKESGILVLGAIAEgcmqgmipylPELIPHLIQCLSDKKALVRSITCWTLSRYAHwvvsqppDTYLKPLMtELLKrilDS 500
Cdd:COG1413    1 VRRAAARALGRLGD----------PAAVPALIAALADEDPDVRAAAARALGRLGD-------PRAVPALL-EALK---DP 59

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379292 501 NKRVQEAACSAFATL-EEEACTELVPYLayildtlvfafskyQHKNLLILYDAIGTLAdsvghHLNKPEYIqmlmPPLIQ 579
Cdd:COG1413   60 DPEVRAAAAEALGRIgDPEAVPALIAAL--------------KDEDPEVRRAAAEALG-----RLGDPAAV----PALLE 116

                        170
                 ....*....|..
gi 530379292 580 kwnMLKDEDKDL 591
Cdd:COG1413  117 ---ALKDPDWEV 125
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 379-471 2.27e-03

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 38.09  E-value: 2.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379292  379 SDWNLRkcsAAALDVLANVYRDEllphILPLLKELLFHHEWVVKESGILVLGAIAEgcmqgmipylPELIPHLIQCL-SD 457
Cdd:pfam13646  12 PDPEVR---AAAIRALGRIGDPE----AVPALLELLKDEDPAVRRAAAEALGKIGD----------PEALPALLELLrDD 74

                          90
                  ....*....|....
gi 530379292  458 KKALVRSITCWTLS 471
Cdd:pfam13646  75 DDDVVRAAAAEALA 88
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 407-513 2.61e-03

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 37.70  E-value: 2.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530379292  407 LPLLKELLFHHE-WVVKESGILVLGAIAEgcmqgmipylPELIPHLIQCLSDKKALVRSITCWTLSRYahwvvsQPPDTY 485
Cdd:pfam13646   1 LPALLQALLRDPdPEVRAAAIRALGRIGD----------PEAVPALLELLKDEDPAVRRAAAEALGKI------GDPEAL 64

                          90       100
                  ....*....|....*....|....*...
gi 530379292  486 lkPLMTELLKRilDSNKRVQEAACSAFA 513
Cdd:pfam13646  65 --PALLELLRD--DDDDVVRAAAAEALA 88
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 196-247 3.69e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 36.19  E-value: 3.69e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 530379292  196 PKIRSHAVACVNQFIISRTQALMLHIDSFIENLFALAGDEEPEVRKNVCRAL 247
Cdd:pfam13513   1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWAL 52
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 237-285 5.37e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 35.81  E-value: 5.37e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 530379292  237 PEVRKNVCRALVMLLEVRMDRLLPHMHNIVEYMLQRTQDQDENVALEAC 285
Cdd:pfam13513   1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAA 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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