NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|530382198|ref|XP_005249261|]
View 

p21-activated protein kinase-interacting protein 1 isoform X2 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 42-276 1.37e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 139.78  E-value: 1.37e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382198  42 HTASLSAVAV--NSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGNRHLISGA-EDGLICIWDAKKWECLK 118
Cdd:cd00200   50 HTGPVRDVAAsaDGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSsRDKTIKVWDVETGKCLT 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382198 119 SIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRsaFIKNIKqnAHI-----VEWSPRGEQYVVIIQNK-IDIYQ 192
Cdd:cd00200  130 TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGK--CVATLT--GHTgevnsVAFSPDGEKLLSSSSDGtIKLWD 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382198 193 LDTASISGTIT-NEKRISSVKFLSESVLAVAGDEE-VIRFFDCDSLVCLCEFKAHENRVKDM-FSfeiPEHHVIVSASSD 269
Cdd:cd00200  206 LSTGKCLGTLRgHENGVNSVAFSPDGYLLASGSEDgTIRVWDLRTGECVQTLSGHTNSVTSLaWS---PDGKRLASGSAD 282


                 ....*..
gi 530382198 270 GFIKMWK 276
Cdd:cd00200  283 GTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 42-276 1.37e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 139.78  E-value: 1.37e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382198  42 HTASLSAVAV--NSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGNRHLISGA-EDGLICIWDAKKWECLK 118
Cdd:cd00200   50 HTGPVRDVAAsaDGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSsRDKTIKVWDVETGKCLT 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382198 119 SIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRsaFIKNIKqnAHI-----VEWSPRGEQYVVIIQNK-IDIYQ 192
Cdd:cd00200  130 TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGK--CVATLT--GHTgevnsVAFSPDGEKLLSSSSDGtIKLWD 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382198 193 LDTASISGTIT-NEKRISSVKFLSESVLAVAGDEE-VIRFFDCDSLVCLCEFKAHENRVKDM-FSfeiPEHHVIVSASSD 269
Cdd:cd00200  206 LSTGKCLGTLRgHENGVNSVAFSPDGYLLASGSEDgTIRVWDLRTGECVQTLSGHTNSVTSLaWS---PDGKRLASGSAD 282


                 ....*..
gi 530382198 270 GFIKMWK 276
Cdd:cd00200  283 GTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
29-278 1.01e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 135.04  E-value: 1.01e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382198  29 QQWTLVADFTHHahTASLSAVAV--NSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGN-RHLISGAEDGL 105
Cdd:COG2319  150 ATGKLLRTLTGH--SGAVTSVAFspDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDgKLLASGSADGT 227

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382198 106 ICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRS-AFIKNIKQNAHIVEWSPRGeQYVVI- 183
Cdd:COG2319  228 VRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELlRTLTGHSGGVNSVAFSPDG-KLLASg 306

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382198 184 -IQNKIDIYQLDTASISGTIT-NEKRISSVKFLSE-SVLAVAGDEEVIRFFDCDSLVCLCEFKAHENRVKDM-FSfeiPE 259
Cdd:COG2319  307 sDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDgKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVaFS---PD 383

                        250
                 ....*....|....*....
gi 530382198 260 HHVIVSASSDGFIKMWKLK 278
Cdd:COG2319  384 GRTLASGSADGTVRLWDLA 402
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 113-152 5.54e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 5.54e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 530382198   113 KWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWN 152
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 55-272 9.13e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 47.77  E-value: 9.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382198  55 FVVTGSKDETIHIYDMKKKIEHGALVHH-----------SGTitCLKFYGNRHLISGAEDGLICIWDAKKWECLKSIKAH 123
Cdd:PLN00181 497 FFATAGVNKKIKIFECESIIKDGRDIHYpvvelasrsklSGI--CWNSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEH 574

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382198 124 KGQVTFLSIHPSGKLALSVGTDK-TLRTWNLVEGRSafIKNIKQNAHI--VEWSPRGEQYVVI--IQNKIDIYQLDTASI 198
Cdd:PLN00181 575 EKRVWSIDYSSADPTLLASGSDDgSVKLWSINQGVS--IGTIKTKANIccVQFPSESGRSLAFgsADHKVYYYDLRNPKL 652

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382198 199 S--GTITNEKRISSVKFLSESVLAVAGDEEVIRFFDCDSLVC------LCEFKAHENrVKDMFSFEIpehhvivsasSDG 270
Cdd:PLN00181 653 PlcTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLSMSISginetpLHSFMGHTN-VKNFVGLSV----------SDG 721


                 ..
gi 530382198 271 FI 272
Cdd:PLN00181 722 YI 723
WD40 pfam00400
WD domain, G-beta repeat;
114-152 1.11e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 1.11e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 530382198  114 WECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWN 152
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 42-276 1.37e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 139.78  E-value: 1.37e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382198  42 HTASLSAVAV--NSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGNRHLISGA-EDGLICIWDAKKWECLK 118
Cdd:cd00200   50 HTGPVRDVAAsaDGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSsRDKTIKVWDVETGKCLT 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382198 119 SIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRsaFIKNIKqnAHI-----VEWSPRGEQYVVIIQNK-IDIYQ 192
Cdd:cd00200  130 TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGK--CVATLT--GHTgevnsVAFSPDGEKLLSSSSDGtIKLWD 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382198 193 LDTASISGTIT-NEKRISSVKFLSESVLAVAGDEE-VIRFFDCDSLVCLCEFKAHENRVKDM-FSfeiPEHHVIVSASSD 269
Cdd:cd00200  206 LSTGKCLGTLRgHENGVNSVAFSPDGYLLASGSEDgTIRVWDLRTGECVQTLSGHTNSVTSLaWS---PDGKRLASGSAD 282


                 ....*..
gi 530382198 270 GFIKMWK 276
Cdd:cd00200  283 GTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
29-278 1.01e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 135.04  E-value: 1.01e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382198  29 QQWTLVADFTHHahTASLSAVAV--NSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGN-RHLISGAEDGL 105
Cdd:COG2319  150 ATGKLLRTLTGH--SGAVTSVAFspDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDgKLLASGSADGT 227

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382198 106 ICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRS-AFIKNIKQNAHIVEWSPRGeQYVVI- 183
Cdd:COG2319  228 VRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELlRTLTGHSGGVNSVAFSPDG-KLLASg 306

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382198 184 -IQNKIDIYQLDTASISGTIT-NEKRISSVKFLSE-SVLAVAGDEEVIRFFDCDSLVCLCEFKAHENRVKDM-FSfeiPE 259
Cdd:COG2319  307 sDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDgKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVaFS---PD 383

                        250
                 ....*....|....*....
gi 530382198 260 HHVIVSASSDGFIKMWKLK 278
Cdd:COG2319  384 GRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
28-283 1.52e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 123.48  E-value: 1.52e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382198  28 EQQWTLVADFTHHAHTASLSAVAVNSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGN-RHLISGAEDGLI 106
Cdd:COG2319   65 AAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDgKTLASGSADGTV 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382198 107 CIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRSAFIKNIKQNA-HIVEWSPRGeQYVVI-- 183
Cdd:COG2319  145 RLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAvRSVAFSPDG-KLLASgs 223

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382198 184 IQNKIDIYQLDTASISGTIT-NEKRISSVKFLSE-SVLAVAGDEEVIRFFDCDSLVCLCEFKAHENRVKDM-FSfeiPEH 260
Cdd:COG2319  224 ADGTVRLWDLATGKLLRTLTgHSGSVRSVAFSPDgRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVaFS---PDG 300

                        250       260
                 ....*....|....*....|...
gi 530382198 261 HVIVSASSDGFIKMWKLKQDKKV 283
Cdd:COG2319  301 KLLASGSDDGTVRLWDLATGKLL 323
WD40 COG2319
WD40 repeat [General function prediction only];
29-283 2.81e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 106.15  E-value: 2.81e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382198  29 QQWTLVADFTHHAHTASLSAVAVNSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKF-YGNRHLISGAEDGLIC 107
Cdd:COG2319   24 ALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFsPDGRLLASASADGTVR 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382198 108 IWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRsaFIKNIKQNAHIVE---WSPRGeQYVVI- 183
Cdd:COG2319  104 LWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGK--LLRTLTGHSGAVTsvaFSPDG-KLLASg 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382198 184 -IQNKIDIYQLDTASISGTITN-EKRISSVKFLSES-VLAVAGDEEVIRFFDCDSLVCLCEFKAHENRVKDM-FSfeiPE 259
Cdd:COG2319  181 sDDGTVRLWDLATGKLLRTLTGhTGAVRSVAFSPDGkLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVaFS---PD 257

                        250       260
                 ....*....|....*....|....
gi 530382198 260 HHVIVSASSDGFIKMWKLKQDKKV 283
Cdd:COG2319  258 GRLLASGSADGTVRLWDLATGELL 281
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 38-152 3.74e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 95.09  E-value: 3.74e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382198  38 THHAHTASLSAVAV--NSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGNRHLI-SGAEDGLICIWDAKKW 114
Cdd:cd00200  172 TLTGHTGEVNSVAFspDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLaSGSEDGTIRVWDLRTG 251

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 530382198 115 ECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWN 152
Cdd:cd00200  252 ECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 40-157 5.55e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 94.71  E-value: 5.55e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382198  40 HAHTASLSAVAV--NSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGN-RHLISGAEDGLICIWDAKKWEC 116
Cdd:cd00200  132 RGHTDWVNSVAFspDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDgEKLLSSSSDGTIKLWDLSTGKC 211

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 530382198 117 LKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEGR 157
Cdd:cd00200  212 LGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGE 252
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 75-283 1.08e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.94  E-value: 1.08e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382198  75 EHGALVHHSGTITCLKF-YGNRHLISGAEDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNL 153
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFsPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382198 154 VEGRSAFIknikQNAHI-----VEWSPRGeQYVV--IIQNKIDIYQLDTASISGTITN-EKRISSVKFL-SESVLAVAGD 224
Cdd:cd00200   81 ETGECVRT----LTGHTsyvssVAFSPDG-RILSssSRDKTIKVWDVETGKCLTTLRGhTDWVNSVAFSpDGTFVASSSQ 155

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382198 225 EEVIRFFDCDSLVCLCEFKAHENRVKDM-FSfeiPEHHVIVSASSDGFIKMWKLKQDKKV 283
Cdd:cd00200  156 DGTIKLWDLRTGKCVATLTGHTGEVNSVaFS---PDGEKLLSSSSDGTIKLWDLSTGKCL 212
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 113-152 5.54e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 5.54e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 530382198   113 KWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWN 152
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
8prop_heme_binding_protein cd20718
eight-bladed beta-propeller heme-binding domain in cytochrome cd1 and similar proteins; ...
 55-206 6.37e-06

eight-bladed beta-propeller heme-binding domain in cytochrome cd1 and similar proteins; Members here contain an 8-bladed beta-propeller heme-binding domain in cytochrome cd1 (nitrite reductase) and similar proteins including NirN and NirF. During denitrification, nitrate (Nar), nitrite (Nir), nitric oxide (Nor), and nitrous oxide (Nos) reductases catalyze the reaction cascade of NO(3-)-> NO(2-)-> NO -> N2O -> N2. The integral membrane proteins NorC, NorB, and NosR form the core assembly platform that binds the nitrate reductase NarGHI and the periplasmic nitrite reductase NirS via its maturation factor NirF. NirN and NirF form a stable complex with the nitrite reductase NirS during enzyme maturation. NirF is involved in heme d1 insertion.


Pssm-ID: 467720 [Multi-domain]  Cd Length: 380  Bit Score: 47.72  E-value: 6.37e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382198  55 FVVTGSKDETIHIYDMK-----KKIEHGALVH-HSGTITCLKFYGNrhlISGAEDGLICIWDAKKWECLKSIKAhKGQVT 128
Cdd:cd20718  210 FIVASQGSNTMWVLDLKtgkvvARIPTGKTPHpGPGATWGRKGVTA---TPHLGEGIVTVWDLDTWKPVKYIPT-PGPGR 285

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382198 129 FLSIHPSGKLalsVGTDKTLRTWN-----LVEGRS----AFIKNIKQN-AHIVEWSPRGEqYVVII---QNKIDIYQLDT 195
Cdd:cd20718  286 FVRTHPSSPY---VWADTVFGPENadeiyVIDKETlkvvKTLIPKPGKrALHPEFTRDGK-YVYVSvwdGGEVVVYDAET 361

                        170
                 ....*....|.
gi 530382198 196 ASISGTITNEK 206
Cdd:cd20718  362 LELVKRIPAET 372
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 55-272 9.13e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 47.77  E-value: 9.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382198  55 FVVTGSKDETIHIYDMKKKIEHGALVHH-----------SGTitCLKFYGNRHLISGAEDGLICIWDAKKWECLKSIKAH 123
Cdd:PLN00181 497 FFATAGVNKKIKIFECESIIKDGRDIHYpvvelasrsklSGI--CWNSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEH 574

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382198 124 KGQVTFLSIHPSGKLALSVGTDK-TLRTWNLVEGRSafIKNIKQNAHI--VEWSPRGEQYVVI--IQNKIDIYQLDTASI 198
Cdd:PLN00181 575 EKRVWSIDYSSADPTLLASGSDDgSVKLWSINQGVS--IGTIKTKANIccVQFPSESGRSLAFgsADHKVYYYDLRNPKL 652

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530382198 199 S--GTITNEKRISSVKFLSESVLAVAGDEEVIRFFDCDSLVC------LCEFKAHENrVKDMFSFEIpehhvivsasSDG 270
Cdd:PLN00181 653 PlcTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLSMSISginetpLHSFMGHTN-VKNFVGLSV----------SDG 721


                 ..
gi 530382198 271 FI 272
Cdd:PLN00181 722 YI 723
WD40 pfam00400
WD domain, G-beta repeat;
114-152 1.11e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 1.11e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 530382198  114 WECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWN 152
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 79-110 1.52e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 1.52e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 530382198    79 LVHHSGTITCLKFYGN-RHLISGAEDGLICIWD 110
Cdd:smart00320   8 LKGHTGPVTSVAFSPDgKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
79-110 4.16e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 4.16e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 530382198   79 LVHHSGTITCLKFYGN-RHLISGAEDGLICIWD 110
Cdd:pfam00400   7 LEGHTGSVTSLAFSPDgKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 235-276 4.39e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 4.39e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 530382198   235 SLVCLCEFKAHENRVKDM-FSfeiPEHHVIVSASSDGFIKMWK 276
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVaFS---PDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
238-275 7.31e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.24  E-value: 7.31e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 530382198  238 CLCEFKAHENRVKDM-FSfeiPEHHVIVSASSDGFIKMW 275
Cdd:pfam00400   3 LLKTLEGHTGSVTSLaFS---PDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 37-69 8.52e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 33.83  E-value: 8.52e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 530382198    37 FTHHAHTASLSAVAV--NSRFVVTGSKDETIHIYD 69
Cdd:smart00320   6 KTLKGHTGPVTSVAFspDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH