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Conserved domains on  [gi|530382724|ref|XP_005249513|]
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potassium channel subfamily K member 5 isoform X1 [Homo sapiens]

Protein Classification

potassium channel family protein( domain architecture ID 10545436)

potassium channel family protein spans the cell membrane to form a conduction pathway or pore, through which selective ions such as potassium, sodium, and calcium, translocate across cell membranes

Gene Ontology:  GO:0005267|GO:0034220
PubMed:  11836519
SCOP:  4000034
TCDB:  1.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 83-137 1.24e-17

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


:

Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 77.31  E-value: 1.24e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 530382724   83 WNWPNAMIFAATVITTIGYGNVAPKTPAGRLFCVFYGLFGVPLCLTWISALGKFF 137
Cdd:pfam07885  22 WSFLDALYFSFVTLTTVGYGDIVPLTDAGRLFTIFYILIGIPLFAIFLAVLGRFL 76
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 168-240 5.70e-09

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


:

Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 52.65  E-value: 5.70e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 530382724  168 VLVHLVIPPFVFMVTEGW--NYIEGLYYSFITISTIGFGDFVAGvnpsanyHALYRYFVELWIYLGLAWLSLFVN 240
Cdd:pfam07885   3 LLLVLIFGTVYYLLEEGWewSFLDALYFSFVTLTTVGYGDIVPL-------TDAGRLFTIFYILIGIPLFAIFLA 70
 
Name Accession Description Interval E-value
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 83-137 1.24e-17

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 77.31  E-value: 1.24e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 530382724   83 WNWPNAMIFAATVITTIGYGNVAPKTPAGRLFCVFYGLFGVPLCLTWISALGKFF 137
Cdd:pfam07885  22 WSFLDALYFSFVTLTTVGYGDIVPLTDAGRLFTIFYILIGIPLFAIFLAVLGRFL 76
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 168-240 5.70e-09

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 52.65  E-value: 5.70e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 530382724  168 VLVHLVIPPFVFMVTEGW--NYIEGLYYSFITISTIGFGDFVAGvnpsanyHALYRYFVELWIYLGLAWLSLFVN 240
Cdd:pfam07885   3 LLLVLIFGTVYYLLEEGWewSFLDALYFSFVTLTTVGYGDIVPL-------TDAGRLFTIFYILIGIPLFAIFLA 70
PRK10537 PRK10537
voltage-gated potassium channel protein;
84-144 1.72e-04

voltage-gated potassium channel protein;


Pssm-ID: 236711 [Multi-domain]  Cd Length: 393  Bit Score: 43.86  E-value: 1.72e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530382724  84 NWPNAMIFAATVITTIGYGNVAPKTPAGRLFCVFYGLFGVPLCLTWISAL-GKFFGGRAKRL 144
Cdd:PRK10537 168 SLSTAFYFSIVTMSTVGYGDIVPVSESARLFTISVIILGITVFATSISAIfGPVIRGNLKRL 229
 
Name Accession Description Interval E-value
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 83-137 1.24e-17

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 77.31  E-value: 1.24e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 530382724   83 WNWPNAMIFAATVITTIGYGNVAPKTPAGRLFCVFYGLFGVPLCLTWISALGKFF 137
Cdd:pfam07885  22 WSFLDALYFSFVTLTTVGYGDIVPLTDAGRLFTIFYILIGIPLFAIFLAVLGRFL 76
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 168-240 5.70e-09

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 52.65  E-value: 5.70e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 530382724  168 VLVHLVIPPFVFMVTEGW--NYIEGLYYSFITISTIGFGDFVAGvnpsanyHALYRYFVELWIYLGLAWLSLFVN 240
Cdd:pfam07885   3 LLLVLIFGTVYYLLEEGWewSFLDALYFSFVTLTTVGYGDIVPL-------TDAGRLFTIFYILIGIPLFAIFLA 70
PRK10537 PRK10537
voltage-gated potassium channel protein;
84-144 1.72e-04

voltage-gated potassium channel protein;


Pssm-ID: 236711 [Multi-domain]  Cd Length: 393  Bit Score: 43.86  E-value: 1.72e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530382724  84 NWPNAMIFAATVITTIGYGNVAPKTPAGRLFCVFYGLFGVPLCLTWISAL-GKFFGGRAKRL 144
Cdd:PRK10537 168 SLSTAFYFSIVTMSTVGYGDIVPVSESARLFTISVIILGITVFATSISAIfGPVIRGNLKRL 229
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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