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Conserved domains on  [gi|530384594|ref|XP_005249728|]
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late secretory pathway protein AVL9 homolog isoform X11 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Avl9 super family cl44577
Transport protein Avl9; Avl9 is a protein involved in exocytic transport from the Golgi. It ...
 16-238 2.92e-123

Transport protein Avl9; Avl9 is a protein involved in exocytic transport from the Golgi. It has been speculated that Avl9 could play a role in deforming membranes for vesicle fission and/or in recruiting cargo.


The actual alignment was detected with superfamily member pfam09794:

Pssm-ID: 430832 [Multi-domain]  Cd Length: 379  Bit Score: 361.98  E-value: 2.92e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530384594   16 VLHIVVVGFHHKKGCQVEFSYPplipgDGHDSHTLPEEWKYLPFLALPDGAHNYQEDTVFFHLP---PRNGNGATVFGIS 92
Cdd:pfam09794   1 ILGICVVDFHHKRGPEIEFWYP-----DLDESSDDPSLWKNLPFQALPDGSHSFEEDFSYFTLLydePNTGPLTTLFGIS 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530384594   93 CYRQIEAKALKVRQADITRETVQKSVCVLSKLPLYGLLQAKLQLITHAYFEEKDFSQISILKELYEHMNS---SLGGASL 169
Cdd:pfam09794  76 CSRQIKSSELLKRPADVTRSTVQKAVVVISRLPIFGQIKDKLSIVTNAYFEQGDFSDTSILVSLYENLNStfkSLGGEEL 155

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530384594  170 EGSQVYLGLSPRDLVLHFRHKVLILFKLILLEKKVLFYISPVNKLVGALMTVLSLFPGMIEHgLSDCSQ 238
Cdd:pfam09794 156 RESDLYVGLSLRELVLKFRHNTLVLFKALLLEKKVLFYGSPVERLCNLQFSLISLIPNLISN-LQDSGS 223
 
Name Accession Description Interval E-value
Avl9 pfam09794
Transport protein Avl9; Avl9 is a protein involved in exocytic transport from the Golgi. It ...
 16-238 2.92e-123

Transport protein Avl9; Avl9 is a protein involved in exocytic transport from the Golgi. It has been speculated that Avl9 could play a role in deforming membranes for vesicle fission and/or in recruiting cargo.


Pssm-ID: 430832 [Multi-domain]  Cd Length: 379  Bit Score: 361.98  E-value: 2.92e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530384594   16 VLHIVVVGFHHKKGCQVEFSYPplipgDGHDSHTLPEEWKYLPFLALPDGAHNYQEDTVFFHLP---PRNGNGATVFGIS 92
Cdd:pfam09794   1 ILGICVVDFHHKRGPEIEFWYP-----DLDESSDDPSLWKNLPFQALPDGSHSFEEDFSYFTLLydePNTGPLTTLFGIS 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530384594   93 CYRQIEAKALKVRQADITRETVQKSVCVLSKLPLYGLLQAKLQLITHAYFEEKDFSQISILKELYEHMNS---SLGGASL 169
Cdd:pfam09794  76 CSRQIKSSELLKRPADVTRSTVQKAVVVISRLPIFGQIKDKLSIVTNAYFEQGDFSDTSILVSLYENLNStfkSLGGEEL 155

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530384594  170 EGSQVYLGLSPRDLVLHFRHKVLILFKLILLEKKVLFYISPVNKLVGALMTVLSLFPGMIEHgLSDCSQ 238
Cdd:pfam09794 156 RESDLYVGLSLRELVLKFRHNTLVLFKALLLEKKVLFYGSPVERLCNLQFSLISLIPNLISN-LQDSGS 223
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 116-226 2.19e-03

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 38.72  E-value: 2.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530384594   116 KSVCVLSKLPLYGLLQAKLQLITHAYFEekdfSQISILKELYEHMNSSLGGASLEGSQVYLG----------------LS 179
Cdd:smart00799   3 KCICILSRLPFFELFRKILNELYRLLPS----SSNLPLELLISLLLYPVPPPGGSLVLVSLGpgdlielqrpldsslpLI 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 530384594   180 PRDLVLHFRH----KVLILFKLILLEKKVLFYISPVNKLVGALMTVLSL-FP 226
Cdd:smart00799  79 DFSLHELFEClgveNILQLFAALLLERRIIFTSSNLSTLSAVIEALLALlYP 130
 
Name Accession Description Interval E-value
Avl9 pfam09794
Transport protein Avl9; Avl9 is a protein involved in exocytic transport from the Golgi. It ...
 16-238 2.92e-123

Transport protein Avl9; Avl9 is a protein involved in exocytic transport from the Golgi. It has been speculated that Avl9 could play a role in deforming membranes for vesicle fission and/or in recruiting cargo.


Pssm-ID: 430832 [Multi-domain]  Cd Length: 379  Bit Score: 361.98  E-value: 2.92e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530384594   16 VLHIVVVGFHHKKGCQVEFSYPplipgDGHDSHTLPEEWKYLPFLALPDGAHNYQEDTVFFHLP---PRNGNGATVFGIS 92
Cdd:pfam09794   1 ILGICVVDFHHKRGPEIEFWYP-----DLDESSDDPSLWKNLPFQALPDGSHSFEEDFSYFTLLydePNTGPLTTLFGIS 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530384594   93 CYRQIEAKALKVRQADITRETVQKSVCVLSKLPLYGLLQAKLQLITHAYFEEKDFSQISILKELYEHMNS---SLGGASL 169
Cdd:pfam09794  76 CSRQIKSSELLKRPADVTRSTVQKAVVVISRLPIFGQIKDKLSIVTNAYFEQGDFSDTSILVSLYENLNStfkSLGGEEL 155

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530384594  170 EGSQVYLGLSPRDLVLHFRHKVLILFKLILLEKKVLFYISPVNKLVGALMTVLSLFPGMIEHgLSDCSQ 238
Cdd:pfam09794 156 RESDLYVGLSLRELVLKFRHNTLVLFKALLLEKKVLFYGSPVERLCNLQFSLISLIPNLISN-LQDSGS 223
Afi1 pfam07792
Docking domain of Afi1 for Arf3 in vesicle trafficking; This domain occurs at the N-terminal ...
 19-76 1.01e-07

Docking domain of Afi1 for Arf3 in vesicle trafficking; This domain occurs at the N-terminal of Afi1, an Arf3p-interacting protein, is a protein necessary for vesicle trafficking in yeast. This domain is the interacting region of the protein which binds to Arf3, the highly conserved small GTPases (ADP-ribosylation factors). Afi1 is distributed asymmetrically at the plasma membrane and is required for polarized distribution of Arf3 but not of an Arf3 guanine nucleotide-exchange factor, Yel1p. However, Afi1 is not required for targeting of Arf3 or Yel1p to the plasma membrane. Afi1 functions as an Arf3 polarization-specific adapter and participates in development of polarity. Although Arf3 is the homolog of human Arf6 it does not function in the same way, not being necessary for endocytosis or for mating factor receptor internalization. In the S phase, however, it is concentrated at the plasma membrane of the emerging bud. Because of its polarized localization and its critical function in the normal budding pattern of yeast, Arf3 is probably a regulator of vesicle trafficking, which is important for polarized growth.


Pssm-ID: 400236  Cd Length: 119  Bit Score: 50.15  E-value: 1.01e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 530384594   19 IVVVGFHHKKGCQVEFSYPPLIPGDGHdSHTLPEewkylpfLALPDGAHNYQED-TVFF 76
Cdd:pfam07792   2 ILVAEFDIDKGPVVKHQYPSAIPGDEG-MQNLAE-------LMLPDQVHKRPQDwTVFF 52
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 116-226 2.19e-03

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 38.72  E-value: 2.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530384594   116 KSVCVLSKLPLYGLLQAKLQLITHAYFEekdfSQISILKELYEHMNSSLGGASLEGSQVYLG----------------LS 179
Cdd:smart00799   3 KCICILSRLPFFELFRKILNELYRLLPS----SSNLPLELLISLLLYPVPPPGGSLVLVSLGpgdlielqrpldsslpLI 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 530384594   180 PRDLVLHFRH----KVLILFKLILLEKKVLFYISPVNKLVGALMTVLSL-FP 226
Cdd:smart00799  79 DFSLHELFEClgveNILQLFAALLLERRIIFTSSNLSTLSAVIEALLALlYP 130
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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