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Conserved domains on  [gi|530386128|ref|XP_005250510|]
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serum paraoxonase/arylesterase 2 isoform X1 [Homo sapiens]

Protein Classification

Arylesterase domain-containing protein( domain architecture ID 10484254)

Arylesterase domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Arylesterase pfam01731
Arylesterase; This family consists of arylesterases (Also known as serum paraoxonase) EC:3.1.1. ...
 99-184 1.43e-47

Arylesterase; This family consists of arylesterases (Also known as serum paraoxonase) EC:3.1.1.2. These enzymes hydrolyse organophosphorus esters such as paraoxon and are found in the liver and blood. They confer resistance to organophosphate toxicity. Human arylesterase (PON1) is associated with HDL and may protect against LDL oxidation.


:

Pssm-ID: 334656  Cd Length: 86  Bit Score: 153.77  E-value: 1.43e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386128   99 NDITAVGPAHFYATNDHYFSDPFLKYLETYLNLHWANVVYYSPNEVKVVAEGFDSANGINISPDDKYIYVADILAHEIHV 178
Cdd:pfam01731   1 NDIVAVGPDSFYATNDHYFGDPFLQNLEMYLGLIWTGVVYYSPSEVKVVASGFSFANGINYSPDKKYIYVASSLRHSIHV 80


                  ....*.
gi 530386128  179 LEKHTN 184
Cdd:pfam01731  81 MKKHAN 86
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 38-228 1.60e-12

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


:

Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 66.07  E-value: 1.60e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386128  38 FDLASFNPHGIstFIDNDDTvyLFVVNHpefknTVEIFKFEEAENSLLHLKTVKHELLPSVNDItAVGPA-HFYATNDHY 116
Cdd:COG3386   44 FAEPSGRPNGL--AFDPDGR--LLVADH-----GRGLVRFDPADGEVTVLADEYGKPLNRPNDG-VVDPDgRLYFTDMGE 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386128 117 FSDPflkyletylnlhwANVVYYSPN-EVKVVAEGFDSANGINISPDDKYIYVADILAHEIHVLEKHTNMNLTQLKVL-- 193
Cdd:COG3386  114 YLPT-------------GALYRVDPDgSLRVLADGLTFPNGIAFSPDGRTLYVADTGAGRIYRFDLDADGTLGNRRVFad 180

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 530386128 194 --ELDTLVDNLSIDpSSGDIWVgCHPNGQKLFVYDPN 228
Cdd:COG3386  181 lpDGPGGPDGLAVD-ADGNLWV-ALWGGGGVVRFDPD 215
 
Name Accession Description Interval E-value
Arylesterase pfam01731
Arylesterase; This family consists of arylesterases (Also known as serum paraoxonase) EC:3.1.1. ...
 99-184 1.43e-47

Arylesterase; This family consists of arylesterases (Also known as serum paraoxonase) EC:3.1.1.2. These enzymes hydrolyse organophosphorus esters such as paraoxon and are found in the liver and blood. They confer resistance to organophosphate toxicity. Human arylesterase (PON1) is associated with HDL and may protect against LDL oxidation.


Pssm-ID: 334656  Cd Length: 86  Bit Score: 153.77  E-value: 1.43e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386128   99 NDITAVGPAHFYATNDHYFSDPFLKYLETYLNLHWANVVYYSPNEVKVVAEGFDSANGINISPDDKYIYVADILAHEIHV 178
Cdd:pfam01731   1 NDIVAVGPDSFYATNDHYFGDPFLQNLEMYLGLIWTGVVYYSPSEVKVVASGFSFANGINYSPDKKYIYVASSLRHSIHV 80


                  ....*.
gi 530386128  179 LEKHTN 184
Cdd:pfam01731  81 MKKHAN 86
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 38-228 1.60e-12

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 66.07  E-value: 1.60e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386128  38 FDLASFNPHGIstFIDNDDTvyLFVVNHpefknTVEIFKFEEAENSLLHLKTVKHELLPSVNDItAVGPA-HFYATNDHY 116
Cdd:COG3386   44 FAEPSGRPNGL--AFDPDGR--LLVADH-----GRGLVRFDPADGEVTVLADEYGKPLNRPNDG-VVDPDgRLYFTDMGE 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386128 117 FSDPflkyletylnlhwANVVYYSPN-EVKVVAEGFDSANGINISPDDKYIYVADILAHEIHVLEKHTNMNLTQLKVL-- 193
Cdd:COG3386  114 YLPT-------------GALYRVDPDgSLRVLADGLTFPNGIAFSPDGRTLYVADTGAGRIYRFDLDADGTLGNRRVFad 180

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 530386128 194 --ELDTLVDNLSIDpSSGDIWVgCHPNGQKLFVYDPN 228
Cdd:COG3386  181 lpDGPGGPDGLAVD-ADGNLWV-ALWGGGGVVRFDPD 215
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 136-181 3.56e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 38.34  E-value: 3.56e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 530386128 136 VVYYSPNEVKV----VAEGFDSANGINISPDDKYIYVADILAHEIHVLEK 181
Cdd:cd14962   80 VFVFDRDGKFLraigAGALFKRPTGIAVDPAGKRLYVVDTLAHKVKVFDL 129
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
144-220 8.67e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 36.98  E-value: 8.67e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 530386128 144 VKVVAEGfDSANGINISPDDKYIYVADILAHEIHVLEKHTNmnlTQLKVLELDTLVDNLSIDPSSGDIWVGCHPNGQ 220
Cdd:COG3391  103 VATIPVG-GGPRGLAVDPDGGRLYVADSGNGRVSVIDTATG---KVVATIPVGAGPHGIAVDPDGKRLYVANSGSNT 175
 
Name Accession Description Interval E-value
Arylesterase pfam01731
Arylesterase; This family consists of arylesterases (Also known as serum paraoxonase) EC:3.1.1. ...
 99-184 1.43e-47

Arylesterase; This family consists of arylesterases (Also known as serum paraoxonase) EC:3.1.1.2. These enzymes hydrolyse organophosphorus esters such as paraoxon and are found in the liver and blood. They confer resistance to organophosphate toxicity. Human arylesterase (PON1) is associated with HDL and may protect against LDL oxidation.


Pssm-ID: 334656  Cd Length: 86  Bit Score: 153.77  E-value: 1.43e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386128   99 NDITAVGPAHFYATNDHYFSDPFLKYLETYLNLHWANVVYYSPNEVKVVAEGFDSANGINISPDDKYIYVADILAHEIHV 178
Cdd:pfam01731   1 NDIVAVGPDSFYATNDHYFGDPFLQNLEMYLGLIWTGVVYYSPSEVKVVASGFSFANGINYSPDKKYIYVASSLRHSIHV 80


                  ....*.
gi 530386128  179 LEKHTN 184
Cdd:pfam01731  81 MKKHAN 86
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 38-228 1.60e-12

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 66.07  E-value: 1.60e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386128  38 FDLASFNPHGIstFIDNDDTvyLFVVNHpefknTVEIFKFEEAENSLLHLKTVKHELLPSVNDItAVGPA-HFYATNDHY 116
Cdd:COG3386   44 FAEPSGRPNGL--AFDPDGR--LLVADH-----GRGLVRFDPADGEVTVLADEYGKPLNRPNDG-VVDPDgRLYFTDMGE 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386128 117 FSDPflkyletylnlhwANVVYYSPN-EVKVVAEGFDSANGINISPDDKYIYVADILAHEIHVLEKHTNMNLTQLKVL-- 193
Cdd:COG3386  114 YLPT-------------GALYRVDPDgSLRVLADGLTFPNGIAFSPDGRTLYVADTGAGRIYRFDLDADGTLGNRRVFad 180

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 530386128 194 --ELDTLVDNLSIDpSSGDIWVgCHPNGQKLFVYDPN 228
Cdd:COG3386  181 lpDGPGGPDGLAVD-ADGNLWV-ALWGGGGVVRFDPD 215
SGL pfam08450
SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in ...
 99-228 2.33e-06

SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.


Pssm-ID: 462480 [Multi-domain]  Cd Length: 246  Bit Score: 47.64  E-value: 2.33e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386128   99 NDItAVGPA-HFYATNDHYFSDPflkyletylNLHWANVVYYSPN-EVKVVAEGFDSANGINISPDDKYIYVADILAHEI 176
Cdd:pfam08450  89 NDG-KVDPDgRFWFGTMGDDEAP---------GGDPGALYRLDPDgKLTRVLDGLTISNGLAWSPDGRTLYFADSPARKI 158

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 530386128  177 HVLE-KHTNMNLTQLKVL----ELDTLVDNLSIDpSSGDIWVgCHPNGQKLFVYDPN 228
Cdd:pfam08450 159 WAYDyDLDGGLISNRRVFadfkPGLGRPDGMAVD-AEGNVWV-ARWGGGKVVRFDPD 213
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
142-229 7.39e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 40.06  E-value: 7.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386128 142 NEVKVVAEGfDSANGINISPDDKYIYVADILAHEIHVLekhtnmnltqlkVLELDT----LVDNLSIDPSSGDIWVgcHP 217
Cdd:COG3391  143 KVVATIPVG-AGPHGIAVDPDGKRLYVANSGSNTVSVI------------VSVIDTatgkVVATIPVGGGPVGVAV--SP 207

                         90
                 ....*....|..
gi 530386128 218 NGQKLFVYDPNN 229
Cdd:COG3391  208 DGRRLYVANRGS 219
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 136-181 3.56e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 38.34  E-value: 3.56e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 530386128 136 VVYYSPNEVKV----VAEGFDSANGINISPDDKYIYVADILAHEIHVLEK 181
Cdd:cd14962   80 VFVFDRDGKFLraigAGALFKRPTGIAVDPAGKRLYVVDTLAHKVKVFDL 129
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
144-220 8.67e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 36.98  E-value: 8.67e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 530386128 144 VKVVAEGfDSANGINISPDDKYIYVADILAHEIHVLEKHTNmnlTQLKVLELDTLVDNLSIDPSSGDIWVGCHPNGQ 220
Cdd:COG3391  103 VATIPVG-GGPRGLAVDPDGGRLYVADSGNGRVSVIDTATG---KVVATIPVGAGPHGIAVDPDGKRLYVANSGSNT 175
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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