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Conserved domains on  [gi|530388898|ref|XP_005250914|]
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regulator of G-protein signaling 22 isoform X1 [Homo sapiens]

Protein Classification

regulator of G-protein signaling domain-containing protein( domain architecture ID 10171656)

regulator of G-protein signaling (RGS) domain-containing protein belongs to a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RGS_RGS22_3 cd08726
Regulator of G protein signaling domain RGS_RGS22_3; The RGS (Regulator of G-protein Signaling) ...
 853-982 7.57e-74

Regulator of G protein signaling domain RGS_RGS22_3; The RGS (Regulator of G-protein Signaling) domain found in the RGS22 protein, a member of the RA/RGS subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. RGS22 contains at least 3 copies of the RGS domain in vertebrata and exists in multiple splicing variants. RGS22 is predominantly expressed in testis and believed to play an important role in spermatogenesis.


:

Pssm-ID: 188681  Cd Length: 130  Bit Score: 240.85  E-value: 7.57e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530388898  853 FSDLLNNKLEFEHFRQFLETHSSSMDLMCWTDIEQFRRITYRDRNQRKAKSIYIKNKYLNKKYFFGPNSPASLYQQNQVM 932
Cdd:cd08726     1 FQDLLHNRLELEFFRKFLEENSASMDLLCWLDIEQFRRIPHTDNAKRDEKAKEIKNKYLNKKYFFGPNSPATKEQQNKVM 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 530388898  933 HLSGGWGKILHEQLDAPVLVEIQKHVQNRLENVWLPLFLASEQFAARQKI 982
Cdd:cd08726    81 HAGGGWGKILHDRPPSSVLIEIQKIVRARLEKHWLPLFLATEQFRRRQAQ 130
RGS_RGS22_2 cd08727
Regulator of G protein signaling domain RGS_RGS22_2; The RGS (Regulator of G-protein Signaling) ...
 670-785 9.51e-59

Regulator of G protein signaling domain RGS_RGS22_2; The RGS (Regulator of G-protein Signaling) domain found in the RGS22 protein, a member of the RA/RGS subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. RGS22 contains at least 3 copies of the RGS domain in vertebrata and exists in multiple splicing variants. RGS22 is predominantly expressed in testis and believed to play an important role in spermatogenesis.


:

Pssm-ID: 188682  Cd Length: 116  Bit Score: 197.27  E-value: 9.51e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530388898  670 VENRAGFFFTKFCEHSGNKLWKNSVYFWFDLQAYHQLFYQETLQPFKVCKQAQYLFATYVAPSATLDIGLQQEKKKEIYM 749
Cdd:cd08727     1 LENRAGNFFTQFCEKSGNKLWKNAVYFWFDLQEYHQLFYTETFQPFKVCRKAQRLFSTYIVPGARHNIGCSVRKRKEIIK 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 530388898  750 KIQPPFEDLFDTAEEYILLLLLEPWTKMVKSDQIAY 785
Cdd:cd08727    81 KLSPPFEDLFDAAEEHILLLLLEPWSKMVKQDEAEY 116
RGS super family cl02565
Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part ...
 1026-1120 7.47e-57

Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. While inactive, G-alpha-subunits bind GDP, which is released and replaced by GTP upon agonist activation. GTP binding leads to dissociation of the alpha-subunit and the beta-gamma-dimer, allowing them to interact with effectors molecules and propagate signaling cascades associated with cellular growth, survival, migration, and invasion. Deactivation of the G-protein signaling controlled by the RGS domain accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, which results in the reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins are also involved in apoptosis and cell proliferation, as well as modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play important roles in neuronal signals modulation. Some RGS proteins are principal elements needed for proper vision.


The actual alignment was detected with superfamily member cd08725:

Pssm-ID: 470619  Cd Length: 123  Bit Score: 192.22  E-value: 7.47e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530388898 1026 LLNPVTSRQFQRFVALKGDLLENGLLFWQEVQKYKDLCHSHCDESVIQKKITTIINCFINSSIPPALQIDIPVEQAQKII 1105
Cdd:cd08725     1 LLNPVTSEQFQRFVSLKGEELENDLLFWLEVQKYKDLCHSHSDEHIIQNKITAIISCFIDSSVPPALQIDIPPEIANRIL 80

                          90
                  ....*....|....*
gi 530388898 1106 EHRKELGPYVFREAQ 1120
Cdd:cd08725    81 EHRRELGPYIFREAQ 95
 
Name Accession Description Interval E-value
RGS_RGS22_3 cd08726
Regulator of G protein signaling domain RGS_RGS22_3; The RGS (Regulator of G-protein Signaling) ...
 853-982 7.57e-74

Regulator of G protein signaling domain RGS_RGS22_3; The RGS (Regulator of G-protein Signaling) domain found in the RGS22 protein, a member of the RA/RGS subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. RGS22 contains at least 3 copies of the RGS domain in vertebrata and exists in multiple splicing variants. RGS22 is predominantly expressed in testis and believed to play an important role in spermatogenesis.


Pssm-ID: 188681  Cd Length: 130  Bit Score: 240.85  E-value: 7.57e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530388898  853 FSDLLNNKLEFEHFRQFLETHSSSMDLMCWTDIEQFRRITYRDRNQRKAKSIYIKNKYLNKKYFFGPNSPASLYQQNQVM 932
Cdd:cd08726     1 FQDLLHNRLELEFFRKFLEENSASMDLLCWLDIEQFRRIPHTDNAKRDEKAKEIKNKYLNKKYFFGPNSPATKEQQNKVM 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 530388898  933 HLSGGWGKILHEQLDAPVLVEIQKHVQNRLENVWLPLFLASEQFAARQKI 982
Cdd:cd08726    81 HAGGGWGKILHDRPPSSVLIEIQKIVRARLEKHWLPLFLATEQFRRRQAQ 130
RGS_RGS22_2 cd08727
Regulator of G protein signaling domain RGS_RGS22_2; The RGS (Regulator of G-protein Signaling) ...
 670-785 9.51e-59

Regulator of G protein signaling domain RGS_RGS22_2; The RGS (Regulator of G-protein Signaling) domain found in the RGS22 protein, a member of the RA/RGS subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. RGS22 contains at least 3 copies of the RGS domain in vertebrata and exists in multiple splicing variants. RGS22 is predominantly expressed in testis and believed to play an important role in spermatogenesis.


Pssm-ID: 188682  Cd Length: 116  Bit Score: 197.27  E-value: 9.51e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530388898  670 VENRAGFFFTKFCEHSGNKLWKNSVYFWFDLQAYHQLFYQETLQPFKVCKQAQYLFATYVAPSATLDIGLQQEKKKEIYM 749
Cdd:cd08727     1 LENRAGNFFTQFCEKSGNKLWKNAVYFWFDLQEYHQLFYTETFQPFKVCRKAQRLFSTYIVPGARHNIGCSVRKRKEIIK 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 530388898  750 KIQPPFEDLFDTAEEYILLLLLEPWTKMVKSDQIAY 785
Cdd:cd08727    81 KLSPPFEDLFDAAEEHILLLLLEPWSKMVKQDEAEY 116
RGS_RGS22_4 cd08725
Regulator of G protein signaling domain RGS_RGS22_4; The RGS (Regulator of G-protein Signaling) ...
 1026-1120 7.47e-57

Regulator of G protein signaling domain RGS_RGS22_4; The RGS (Regulator of G-protein Signaling) domain found in the RGS22 protein, a member of the RA/RGS subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. RGS22 contains at least 3 copies of the RGS domain in vertebrata and exists in multiple splicing variants. RGS22 is predominantly expressed in testis and believed to play an important role in spermatogenesis.


Pssm-ID: 188680  Cd Length: 123  Bit Score: 192.22  E-value: 7.47e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530388898 1026 LLNPVTSRQFQRFVALKGDLLENGLLFWQEVQKYKDLCHSHCDESVIQKKITTIINCFINSSIPPALQIDIPVEQAQKII 1105
Cdd:cd08725     1 LLNPVTSEQFQRFVSLKGEELENDLLFWLEVQKYKDLCHSHSDEHIIQNKITAIISCFIDSSVPPALQIDIPPEIANRIL 80

                          90
                  ....*....|....*
gi 530388898 1106 EHRKELGPYVFREAQ 1120
Cdd:cd08725    81 EHRRELGPYIFREAQ 95
RGS smart00315
Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins ...
 1022-1126 1.01e-11

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 214613  Cd Length: 118  Bit Score: 63.06  E-value: 1.01e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530388898   1022 FRKALLNPVTSRQFQRFvaLKGDLLENGLLFWQEVQKYKDLchshCDESVIQKKITTIINCFINSSIPPALQIDI-PVEQ 1100
Cdd:smart00315    2 LESLLSDPIGRLLFREF--LESEFSEENLEFWLAVEEFKKA----EDDEERIAKAREIYDKFLSPNAPKEVNLDSdLREK 75

                            90       100
                    ....*....|....*....|....*.
gi 530388898   1101 AQKIIEHRkELGPYVFREAQDGIKQY 1126
Cdd:smart00315   76 IEENLESE-EPPPDLFDEAQREVYEL 100
RGS pfam00615
Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for ...
 852-976 1.37e-07

Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 459870  Cd Length: 117  Bit Score: 51.08  E-value: 1.37e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530388898   852 KFSDLLNNKLEFEHFRQFLETHSSSMDLMCWTDIEQFRRITYRDRNQRKAKSIYikNKYLNkkyffgPNSPASLYQQNQV 931
Cdd:pfam00615    1 SFDSLLEDQPGRRLFRQFLESEFSEENLEFWLACEEFKKADPDEERLKKAKEIY--NEFLA------PGSPKEINLDSDL 72

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 530388898   932 M-HLSGGwgkiLHEQLDAPVLVEIQKHVQNRLENVWLPLFLASEQF 976
Cdd:pfam00615   73 ReEIREN----LEKEPTRDLFDEAQAEVYELMEKDSYPRFLKSPLY 114
RGS smart00315
Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins ...
 852-976 4.48e-06

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 214613  Cd Length: 118  Bit Score: 46.88  E-value: 4.48e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530388898    852 KFSDLLNNKLEFEHFRQFLETHSSSMDLMCWTDIEQFRRITYRDRNQRKAKSIYIKnkylnkkyFFGPNSPASLYQQNQV 931
Cdd:smart00315    1 SLESLLSDPIGRLLFREFLESEFSEENLEFWLAVEEFKKAEDDEERIAKAREIYDK--------FLSPNAPKEVNLDSDL 72

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*.
gi 530388898    932 M-HLSGGwgkILHEQLDAPVLVEIQKHVQNRLENVWLPLFLASEQF 976
Cdd:smart00315   73 ReKIEEN---LESEEPPPDLFDEAQREVYELLEKDSFPRFLESDYY 115
RGS pfam00615
Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for ...
 1022-1132 2.04e-05

Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 459870  Cd Length: 117  Bit Score: 44.91  E-value: 2.04e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530388898  1022 FRKALLNPVTSRQFQRFvaLKGDLLENGLLFWQEVQKYKdlchSHCDESVIQKKITTIINCFINSSIPPALQIDipvEQA 1101
Cdd:pfam00615    2 FDSLLEDQPGRRLFRQF--LESEFSEENLEFWLACEEFK----KADPDEERLKKAKEIYNEFLAPGSPKEINLD---SDL 72

                           90       100       110
                   ....*....|....*....|....*....|....
gi 530388898  1102 QKIIEHR--KELGPYVFREAQDGIKQY-ANTSVP 1132
Cdd:pfam00615   73 REEIRENleKEPTRDLFDEAQAEVYELmEKDSYP 106
 
Name Accession Description Interval E-value
RGS_RGS22_3 cd08726
Regulator of G protein signaling domain RGS_RGS22_3; The RGS (Regulator of G-protein Signaling) ...
 853-982 7.57e-74

Regulator of G protein signaling domain RGS_RGS22_3; The RGS (Regulator of G-protein Signaling) domain found in the RGS22 protein, a member of the RA/RGS subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. RGS22 contains at least 3 copies of the RGS domain in vertebrata and exists in multiple splicing variants. RGS22 is predominantly expressed in testis and believed to play an important role in spermatogenesis.


Pssm-ID: 188681  Cd Length: 130  Bit Score: 240.85  E-value: 7.57e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530388898  853 FSDLLNNKLEFEHFRQFLETHSSSMDLMCWTDIEQFRRITYRDRNQRKAKSIYIKNKYLNKKYFFGPNSPASLYQQNQVM 932
Cdd:cd08726     1 FQDLLHNRLELEFFRKFLEENSASMDLLCWLDIEQFRRIPHTDNAKRDEKAKEIKNKYLNKKYFFGPNSPATKEQQNKVM 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 530388898  933 HLSGGWGKILHEQLDAPVLVEIQKHVQNRLENVWLPLFLASEQFAARQKI 982
Cdd:cd08726    81 HAGGGWGKILHDRPPSSVLIEIQKIVRARLEKHWLPLFLATEQFRRRQAQ 130
RGS_RGS22_2 cd08727
Regulator of G protein signaling domain RGS_RGS22_2; The RGS (Regulator of G-protein Signaling) ...
 670-785 9.51e-59

Regulator of G protein signaling domain RGS_RGS22_2; The RGS (Regulator of G-protein Signaling) domain found in the RGS22 protein, a member of the RA/RGS subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. RGS22 contains at least 3 copies of the RGS domain in vertebrata and exists in multiple splicing variants. RGS22 is predominantly expressed in testis and believed to play an important role in spermatogenesis.


Pssm-ID: 188682  Cd Length: 116  Bit Score: 197.27  E-value: 9.51e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530388898  670 VENRAGFFFTKFCEHSGNKLWKNSVYFWFDLQAYHQLFYQETLQPFKVCKQAQYLFATYVAPSATLDIGLQQEKKKEIYM 749
Cdd:cd08727     1 LENRAGNFFTQFCEKSGNKLWKNAVYFWFDLQEYHQLFYTETFQPFKVCRKAQRLFSTYIVPGARHNIGCSVRKRKEIIK 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 530388898  750 KIQPPFEDLFDTAEEYILLLLLEPWTKMVKSDQIAY 785
Cdd:cd08727    81 KLSPPFEDLFDAAEEHILLLLLEPWSKMVKQDEAEY 116
RGS_RGS22_4 cd08725
Regulator of G protein signaling domain RGS_RGS22_4; The RGS (Regulator of G-protein Signaling) ...
 1026-1120 7.47e-57

Regulator of G protein signaling domain RGS_RGS22_4; The RGS (Regulator of G-protein Signaling) domain found in the RGS22 protein, a member of the RA/RGS subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. RGS22 contains at least 3 copies of the RGS domain in vertebrata and exists in multiple splicing variants. RGS22 is predominantly expressed in testis and believed to play an important role in spermatogenesis.


Pssm-ID: 188680  Cd Length: 123  Bit Score: 192.22  E-value: 7.47e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530388898 1026 LLNPVTSRQFQRFVALKGDLLENGLLFWQEVQKYKDLCHSHCDESVIQKKITTIINCFINSSIPPALQIDIPVEQAQKII 1105
Cdd:cd08725     1 LLNPVTSEQFQRFVSLKGEELENDLLFWLEVQKYKDLCHSHSDEHIIQNKITAIISCFIDSSVPPALQIDIPPEIANRIL 80

                          90
                  ....*....|....*
gi 530388898 1106 EHRKELGPYVFREAQ 1120
Cdd:cd08725    81 EHRRELGPYIFREAQ 95
RGS cd07440
Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part ...
 857-976 6.95e-19

Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. While inactive, G-alpha-subunits bind GDP, which is released and replaced by GTP upon agonist activation. GTP binding leads to dissociation of the alpha-subunit and the beta-gamma-dimer, allowing them to interact with effectors molecules and propagate signaling cascades associated with cellular growth, survival, migration, and invasion. Deactivation of the G-protein signaling controlled by the RGS domain accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, which results in the reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins are also involved in apoptosis and cell proliferation, as well as modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play important roles in neuronal signals modulation. Some RGS proteins are principal elements needed for proper vision.


Pssm-ID: 188659 [Multi-domain]  Cd Length: 113  Bit Score: 83.21  E-value: 6.95e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530388898  857 LNNKLEFEHFRQFLETHSSSMDLMCWTDIEQFRRITYRDRnQRKAKSIYIKNKYLNKKYFFGPNSPASLyqQNQVMHlsg 936
Cdd:cd07440     1 LRDPYGLEYFRQFLKSEHCEENLEFWLAVEKFKKTTSSDE-ELKSKAKEIYDKYISKDAPKEINIPESI--REEIEE--- 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 530388898  937 gwgKILHEQLDAPVLVEIQKHVQNRLENVWLPLFLASEQF 976
Cdd:cd07440    75 ---NLEEPYPDPDCFDEAQEHILNLLEKDSYPRFLKSDLY 111
RGS smart00315
Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins ...
 1022-1126 1.01e-11

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 214613  Cd Length: 118  Bit Score: 63.06  E-value: 1.01e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530388898   1022 FRKALLNPVTSRQFQRFvaLKGDLLENGLLFWQEVQKYKDLchshCDESVIQKKITTIINCFINSSIPPALQIDI-PVEQ 1100
Cdd:smart00315    2 LESLLSDPIGRLLFREF--LESEFSEENLEFWLAVEEFKKA----EDDEERIAKAREIYDKFLSPNAPKEVNLDSdLREK 75

                            90       100
                    ....*....|....*....|....*.
gi 530388898   1101 AQKIIEHRkELGPYVFREAQDGIKQY 1126
Cdd:smart00315   76 IEENLESE-EPPPDLFDEAQREVYEL 100
RGS cd07440
Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part ...
 676-782 7.36e-11

Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. While inactive, G-alpha-subunits bind GDP, which is released and replaced by GTP upon agonist activation. GTP binding leads to dissociation of the alpha-subunit and the beta-gamma-dimer, allowing them to interact with effectors molecules and propagate signaling cascades associated with cellular growth, survival, migration, and invasion. Deactivation of the G-protein signaling controlled by the RGS domain accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, which results in the reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins are also involved in apoptosis and cell proliferation, as well as modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play important roles in neuronal signals modulation. Some RGS proteins are principal elements needed for proper vision.


Pssm-ID: 188659 [Multi-domain]  Cd Length: 113  Bit Score: 60.48  E-value: 7.36e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530388898  676 FFFTKFCEHSGNKlwkNSVYFWFDLQAYHQLFYQETlqpfKVCKQAQYLFATYVAPSATLDIGLQQEKKKEIYMKIQPP- 754
Cdd:cd07440     8 EYFRQFLKSEHCE---ENLEFWLAVEKFKKTTSSDE----ELKSKAKEIYDKYISKDAPKEINIPESIREEIEENLEEPy 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 530388898  755 -FEDLFDTAEEYILLL-LLEPWTKMVKSDQ 782
Cdd:cd07440    81 pDPDCFDEAQEHILNLlEKDSYPRFLKSDL 110
RGS pfam00615
Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for ...
 852-976 1.37e-07

Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 459870  Cd Length: 117  Bit Score: 51.08  E-value: 1.37e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530388898   852 KFSDLLNNKLEFEHFRQFLETHSSSMDLMCWTDIEQFRRITYRDRNQRKAKSIYikNKYLNkkyffgPNSPASLYQQNQV 931
Cdd:pfam00615    1 SFDSLLEDQPGRRLFRQFLESEFSEENLEFWLACEEFKKADPDEERLKKAKEIY--NEFLA------PGSPKEINLDSDL 72

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 530388898   932 M-HLSGGwgkiLHEQLDAPVLVEIQKHVQNRLENVWLPLFLASEQF 976
Cdd:pfam00615   73 ReEIREN----LEKEPTRDLFDEAQAEVYELMEKDSYPRFLKSPLY 114
RGS smart00315
Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins ...
 852-976 4.48e-06

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 214613  Cd Length: 118  Bit Score: 46.88  E-value: 4.48e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530388898    852 KFSDLLNNKLEFEHFRQFLETHSSSMDLMCWTDIEQFRRITYRDRNQRKAKSIYIKnkylnkkyFFGPNSPASLYQQNQV 931
Cdd:smart00315    1 SLESLLSDPIGRLLFREFLESEFSEENLEFWLAVEEFKKAEDDEERIAKAREIYDK--------FLSPNAPKEVNLDSDL 72

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*.
gi 530388898    932 M-HLSGGwgkILHEQLDAPVLVEIQKHVQNRLENVWLPLFLASEQF 976
Cdd:smart00315   73 ReKIEEN---LESEEPPPDLFDEAQREVYELLEKDSFPRFLESDYY 115
RGS-like_2 cd08728
Uncharacterized Regulator of G protein Signaling (RGS) domain subfamily, child 2; These ...
 857-1039 8.02e-06

Uncharacterized Regulator of G protein Signaling (RGS) domain subfamily, child 2; These uncharacterized RGS-like domains consists largely of hypothetical proteins. The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play an important role in neuronal signal modulation. Some RGS proteins are the principal elements needed for proper vision.


Pssm-ID: 188683  Cd Length: 179  Bit Score: 47.53  E-value: 8.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530388898  857 LNNKLEFEHFRQFLETHSSSMDLMCWTDIEQFRRITYRDRNQRKAKSIYiknkylnKKYFFGPNSPASLYQQNQVMhlsg 936
Cdd:cd08728     1 LRNHTHLEYFKRFLKSRGSDGPLLFWIAVEKMRVEENEKEQKAKIELIV-------KRYFHGQDPPGVLLQCEAII---- 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530388898  937 gwgkILHEQLDAPV----LVEIQKHVQNRLENVWLPLFlaSEQFAARQkIKVQMKDIAEELLLQKAEKKIGVWKPVESKW 1012
Cdd:cd08728    70 ----IREIAMMKVVttsmLLSIQHLVSKSLEERWFKKY--QDTFPDCP-HEVEPDEEIKVPLKPTKLKAPHVISSQKRAW 142

                         170       180       190
                  ....*....|....*....|....*....|
gi 530388898 1013 ---ISSSCKIIAFRKALLNPVTSRQFQRFV 1039
Cdd:cd08728   143 eifISFIRSFIKFRRFMVNREIRQEFEDYL 172
RGS pfam00615
Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for ...
 1022-1132 2.04e-05

Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 459870  Cd Length: 117  Bit Score: 44.91  E-value: 2.04e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530388898  1022 FRKALLNPVTSRQFQRFvaLKGDLLENGLLFWQEVQKYKdlchSHCDESVIQKKITTIINCFINSSIPPALQIDipvEQA 1101
Cdd:pfam00615    2 FDSLLEDQPGRRLFRQF--LESEFSEENLEFWLACEEFK----KADPDEERLKKAKEIYNEFLAPGSPKEINLD---SDL 72

                           90       100       110
                   ....*....|....*....|....*....|....
gi 530388898  1102 QKIIEHR--KELGPYVFREAQDGIKQY-ANTSVP 1132
Cdd:pfam00615   73 REEIRENleKEPTRDLFDEAQAEVYELmEKDSYP 106
RGS cd07440
Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part ...
 1026-1120 1.29e-04

Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. While inactive, G-alpha-subunits bind GDP, which is released and replaced by GTP upon agonist activation. GTP binding leads to dissociation of the alpha-subunit and the beta-gamma-dimer, allowing them to interact with effectors molecules and propagate signaling cascades associated with cellular growth, survival, migration, and invasion. Deactivation of the G-protein signaling controlled by the RGS domain accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, which results in the reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins are also involved in apoptosis and cell proliferation, as well as modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play important roles in neuronal signals modulation. Some RGS proteins are principal elements needed for proper vision.


Pssm-ID: 188659 [Multi-domain]  Cd Length: 113  Bit Score: 42.76  E-value: 1.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530388898 1026 LLNPVTSRQFQRFVALKGDLlENgLLFWQEVQKYKDLCHShcdESVIQKKITTIINCFINSSIPPALQIDipvEQAQKII 1105
Cdd:cd07440     1 LRDPYGLEYFRQFLKSEHCE-EN-LEFWLAVEKFKKTTSS---DEELKSKAKEIYDKYISKDAPKEINIP---ESIREEI 72

                          90
                  ....*....|....*...
gi 530388898 1106 EHR---KELGPYVFREAQ 1120
Cdd:cd07440    73 EENleePYPDPDCFDEAQ 90
RGS_RGS13 cd08716
Regulator of G protein signaling (RGS) domain found in the RGS13 protein; The RGS (Regulator ...
 683-766 3.30e-03

Regulator of G protein signaling (RGS) domain found in the RGS13 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS13 protein. RGS13 is member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS13 is predominantly expressed in T and B lymphocytes and in mast cells, and plays a role in adaptive immune responses. RGS13 also found in Rgs13, which is also expressed in dendritic cells and in neuroendocrine cells of the thymus, gastrointestinal, and respiratory tracts. Outside of the GPCR pathway, RGS5 interacts with the PIP3 protein.


Pssm-ID: 188671  Cd Length: 114  Bit Score: 38.75  E-value: 3.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530388898  683 EHSgnklwKNSVYFWFDLQAYHQLFYQetlqpFKVCKQAQYLFATYVAPSATLDIGLQQEKKKEIYMKIQPPFEDLFDTA 762
Cdd:cd08716    21 EHS-----DENIEFWLACETYKKIASQ-----RKRISMARKLFASYIQPQAPREINIDSPTRKAIIRNIQEPTQSCFDEA 90


                  ....
gi 530388898  763 EEYI 766
Cdd:cd08716    91 QRIV 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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