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Conserved domains on  [gi|530390749|ref|XP_005251869|]
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intracellular hyaluronan-binding protein 4 isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HABP4_PAI-RBP1 pfam04774
Hyaluronan / mRNA binding family; This family includes the HABP4 family of hyaluronan-binding ...
 102-206 1.94e-18

Hyaluronan / mRNA binding family; This family includes the HABP4 family of hyaluronan-binding proteins, and the PAI-1 mRNA-binding protein, PAI-RBP1. HABP4 has been observed to bind hyaluronan (a glucosaminoglycan), but it is not known whether this is its primary role in vivo. It has also been observed to bind RNA, but with a lower affinity than that for hyaluronan. PAI-1 mRNA-binding protein specifically binds the mRNA of type-1 plasminogen activator inhibitor (PAI-1), and is thought to be involved in regulation of mRNA stability. However, in both cases, the sequence motifs predicted to be important for ligand binding are not conserved throughout the family, so it is not known whether members of this family share a common function.


:

Pssm-ID: 461421  Cd Length: 108  Bit Score: 78.95  E-value: 1.94e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390749  102 GKREFERYGGNDKiavRTEDNMGGCGVRTWGSGKDTSDV---EPTAPMEEPTVVEESQGTPE-----EESPAKVPEleVE 173
Cdd:pfam04774   1 GKREFDRHSGTGR---GPEEKRDGAGRHNWGTVKDEIEApeeEEAENEMEKNNDAEKEAGEEetdenEEAAAAEEE--EK 75

                          90       100       110
                  ....*....|....*....|....*....|...
gi 530390749  174 EETQVQEMTLDEWKNLQEQTRPKPEFNIRKPES 206
Cdd:pfam04774  76 EPNEDKEMTLDEYKKVQEEKRALPAFNIRKRKE 108
IHABP4_N super family cl24679
Intracellular hyaluronan-binding protein 4 N-terminal; IHABP4_N is the N-terminal region of ...
 7-52 7.48e-13

Intracellular hyaluronan-binding protein 4 N-terminal; IHABP4_N is the N-terminal region of intracellular hyaluronan-binding protein 4-like and SERPINE1 mRNA binding protein 1-like proteins. This region carries nuclear localization sites, and may also be involved in the binding to some of the partners in the translational machinery.


The actual alignment was detected with superfamily member pfam16174:

Pssm-ID: 465041 [Multi-domain]  Cd Length: 140  Bit Score: 64.81  E-value: 7.48e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 530390749    7 GQKRTPRRGEQQGWNDSRGPEGMLERAERRSYREYRPYETERQADF 52
Cdd:pfam16174  95 GERRPPRRGEQQGQGEGRRTPPRRERGERRPFRERRNEEDNRQGEF 140
IHABP4_N super family cl24679
Intracellular hyaluronan-binding protein 4 N-terminal; IHABP4_N is the N-terminal region of ...
 210-297 6.82e-06

Intracellular hyaluronan-binding protein 4 N-terminal; IHABP4_N is the N-terminal region of intracellular hyaluronan-binding protein 4-like and SERPINE1 mRNA binding protein 1-like proteins. This region carries nuclear localization sites, and may also be involved in the binding to some of the partners in the translational machinery.


The actual alignment was detected with superfamily member pfam16174:

Pssm-ID: 465041 [Multi-domain]  Cd Length: 140  Bit Score: 44.78  E-value: 6.82e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390749  210 SKAVVIHKSKYRDDMVKDDYEDDSHVFRKPANDITSQLEINFGNLPRPGRGARGG--TRGGRGRIRRAENYGPRAEVVMQ 287
Cdd:pfam16174   1 MQESFGCVVTNRFDQLLDDESDPFDVLREAENKKKLQLKIKFGEKANKGKGAGPRggPRGGQARIGRKESQKDRKNDVAS 80

                          90
                  ....*....|
gi 530390749  288 DVAPNPDDPE 297
Cdd:pfam16174  81 GQPDKPGGGG 90
 
Name Accession Description Interval E-value
HABP4_PAI-RBP1 pfam04774
Hyaluronan / mRNA binding family; This family includes the HABP4 family of hyaluronan-binding ...
 102-206 1.94e-18

Hyaluronan / mRNA binding family; This family includes the HABP4 family of hyaluronan-binding proteins, and the PAI-1 mRNA-binding protein, PAI-RBP1. HABP4 has been observed to bind hyaluronan (a glucosaminoglycan), but it is not known whether this is its primary role in vivo. It has also been observed to bind RNA, but with a lower affinity than that for hyaluronan. PAI-1 mRNA-binding protein specifically binds the mRNA of type-1 plasminogen activator inhibitor (PAI-1), and is thought to be involved in regulation of mRNA stability. However, in both cases, the sequence motifs predicted to be important for ligand binding are not conserved throughout the family, so it is not known whether members of this family share a common function.


Pssm-ID: 461421  Cd Length: 108  Bit Score: 78.95  E-value: 1.94e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390749  102 GKREFERYGGNDKiavRTEDNMGGCGVRTWGSGKDTSDV---EPTAPMEEPTVVEESQGTPE-----EESPAKVPEleVE 173
Cdd:pfam04774   1 GKREFDRHSGTGR---GPEEKRDGAGRHNWGTVKDEIEApeeEEAENEMEKNNDAEKEAGEEetdenEEAAAAEEE--EK 75

                          90       100       110
                  ....*....|....*....|....*....|...
gi 530390749  174 EETQVQEMTLDEWKNLQEQTRPKPEFNIRKPES 206
Cdd:pfam04774  76 EPNEDKEMTLDEYKKVQEEKRALPAFNIRKRKE 108
IHABP4_N pfam16174
Intracellular hyaluronan-binding protein 4 N-terminal; IHABP4_N is the N-terminal region of ...
 7-52 7.48e-13

Intracellular hyaluronan-binding protein 4 N-terminal; IHABP4_N is the N-terminal region of intracellular hyaluronan-binding protein 4-like and SERPINE1 mRNA binding protein 1-like proteins. This region carries nuclear localization sites, and may also be involved in the binding to some of the partners in the translational machinery.


Pssm-ID: 465041 [Multi-domain]  Cd Length: 140  Bit Score: 64.81  E-value: 7.48e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 530390749    7 GQKRTPRRGEQQGWNDSRGPEGMLERAERRSYREYRPYETERQADF 52
Cdd:pfam16174  95 GERRPPRRGEQQGQGEGRRTPPRRERGERRPFRERRNEEDNRQGEF 140
IHABP4_N pfam16174
Intracellular hyaluronan-binding protein 4 N-terminal; IHABP4_N is the N-terminal region of ...
 210-297 6.82e-06

Intracellular hyaluronan-binding protein 4 N-terminal; IHABP4_N is the N-terminal region of intracellular hyaluronan-binding protein 4-like and SERPINE1 mRNA binding protein 1-like proteins. This region carries nuclear localization sites, and may also be involved in the binding to some of the partners in the translational machinery.


Pssm-ID: 465041 [Multi-domain]  Cd Length: 140  Bit Score: 44.78  E-value: 6.82e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390749  210 SKAVVIHKSKYRDDMVKDDYEDDSHVFRKPANDITSQLEINFGNLPRPGRGARGG--TRGGRGRIRRAENYGPRAEVVMQ 287
Cdd:pfam16174   1 MQESFGCVVTNRFDQLLDDESDPFDVLREAENKKKLQLKIKFGEKANKGKGAGPRggPRGGQARIGRKESQKDRKNDVAS 80

                          90
                  ....*....|
gi 530390749  288 DVAPNPDDPE 297
Cdd:pfam16174  81 GQPDKPGGGG 90
 
Name Accession Description Interval E-value
HABP4_PAI-RBP1 pfam04774
Hyaluronan / mRNA binding family; This family includes the HABP4 family of hyaluronan-binding ...
 102-206 1.94e-18

Hyaluronan / mRNA binding family; This family includes the HABP4 family of hyaluronan-binding proteins, and the PAI-1 mRNA-binding protein, PAI-RBP1. HABP4 has been observed to bind hyaluronan (a glucosaminoglycan), but it is not known whether this is its primary role in vivo. It has also been observed to bind RNA, but with a lower affinity than that for hyaluronan. PAI-1 mRNA-binding protein specifically binds the mRNA of type-1 plasminogen activator inhibitor (PAI-1), and is thought to be involved in regulation of mRNA stability. However, in both cases, the sequence motifs predicted to be important for ligand binding are not conserved throughout the family, so it is not known whether members of this family share a common function.


Pssm-ID: 461421  Cd Length: 108  Bit Score: 78.95  E-value: 1.94e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390749  102 GKREFERYGGNDKiavRTEDNMGGCGVRTWGSGKDTSDV---EPTAPMEEPTVVEESQGTPE-----EESPAKVPEleVE 173
Cdd:pfam04774   1 GKREFDRHSGTGR---GPEEKRDGAGRHNWGTVKDEIEApeeEEAENEMEKNNDAEKEAGEEetdenEEAAAAEEE--EK 75

                          90       100       110
                  ....*....|....*....|....*....|...
gi 530390749  174 EETQVQEMTLDEWKNLQEQTRPKPEFNIRKPES 206
Cdd:pfam04774  76 EPNEDKEMTLDEYKKVQEEKRALPAFNIRKRKE 108
IHABP4_N pfam16174
Intracellular hyaluronan-binding protein 4 N-terminal; IHABP4_N is the N-terminal region of ...
 7-52 7.48e-13

Intracellular hyaluronan-binding protein 4 N-terminal; IHABP4_N is the N-terminal region of intracellular hyaluronan-binding protein 4-like and SERPINE1 mRNA binding protein 1-like proteins. This region carries nuclear localization sites, and may also be involved in the binding to some of the partners in the translational machinery.


Pssm-ID: 465041 [Multi-domain]  Cd Length: 140  Bit Score: 64.81  E-value: 7.48e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 530390749    7 GQKRTPRRGEQQGWNDSRGPEGMLERAERRSYREYRPYETERQADF 52
Cdd:pfam16174  95 GERRPPRRGEQQGQGEGRRTPPRRERGERRPFRERRNEEDNRQGEF 140
IHABP4_N pfam16174
Intracellular hyaluronan-binding protein 4 N-terminal; IHABP4_N is the N-terminal region of ...
 210-297 6.82e-06

Intracellular hyaluronan-binding protein 4 N-terminal; IHABP4_N is the N-terminal region of intracellular hyaluronan-binding protein 4-like and SERPINE1 mRNA binding protein 1-like proteins. This region carries nuclear localization sites, and may also be involved in the binding to some of the partners in the translational machinery.


Pssm-ID: 465041 [Multi-domain]  Cd Length: 140  Bit Score: 44.78  E-value: 6.82e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390749  210 SKAVVIHKSKYRDDMVKDDYEDDSHVFRKPANDITSQLEINFGNLPRPGRGARGG--TRGGRGRIRRAENYGPRAEVVMQ 287
Cdd:pfam16174   1 MQESFGCVVTNRFDQLLDDESDPFDVLREAENKKKLQLKIKFGEKANKGKGAGPRggPRGGQARIGRKESQKDRKNDVAS 80

                          90
                  ....*....|
gi 530390749  288 DVAPNPDDPE 297
Cdd:pfam16174  81 GQPDKPGGGG 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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