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Conserved domains on  [gi|530391003|ref|XP_005251991|]
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protein crumbs homolog 2 isoform X5 [Homo sapiens]

Protein Classification

EGF_CA and LamG domain-containing protein( domain architecture ID 10810331)

EGF_CA and LamG domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 133-256 1.72e-11

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 62.44  E-value: 1.72e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391003  133 FRTTLPAGTL-ATRNDTKESLELALVAATLQATLwSYSTTVLVLRLPDLALNDGHWHQVEVVLHLATLELRLwhEGCPAR 211
Cdd:pfam02210   1 FRTRQPNGLLlYAGGGGSDFLALELVNGRLVLRY-DLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSV--DGQTVV 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 530391003  212 LCVASGPVALAST-------ASATPLPAGISSAQLGdatFAGCLQDVRVDGH 256
Cdd:pfam02210  78 SSLPPGESLLLNLngplylgGLPPLLLLPALPVRAG---FVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 321-441 7.66e-11

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 61.28  E-value: 7.66e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391003 321 GAPSSASFLLQELPGPNLTVSFLLRTRESAGLLLQFANDSAAG-LTVFLSEGRIRAEV-PGSPAVVLP-------GRWD- 390
Cdd:cd00110    5 SGSSYVRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGGDfLALELEDGRLVLRYdLGSGSLVLSsktplndGQWHs 84

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 530391003 391 --------------DGLRHLVMLSFGPDQLQDLGQHVHVGG--RLLAADSQPWGGPFRGCLQDLRLD 441
Cdd:cd00110   85 vsverngrsvtlsvDGERVVESGSPGGSALLNLDGPLYLGGlpEDLKSPGLPVSPGFVGCIRDLKVN 151
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 26-61 5.80e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.56  E-value: 5.80e-08
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 530391003  26 DVDECLS-DPCLHGGTCSDTVAGYICRCPETWGGRDC 61
Cdd:cd00054    1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
LamG super family cl22861
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 568-692 4.40e-07

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


The actual alignment was detected with superfamily member pfam00054:

Pssm-ID: 473984 [Multi-domain]  Cd Length: 131  Bit Score: 50.01  E-value: 4.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391003  568 FRTRDSEAWLLrAAAGALEGVWLAV--RNGSLAGGVRGGHGLpgAVLPIPgPRVADGAWHRVRLAMERpaattsRWL-LW 644
Cdd:pfam00054   1 FRTTEPSGLLL-YNGTQTERDFLALelRDGRLEVSYDLGSGA--AVVRSG-DKLNDGKWHSVELERNG------RSGtLS 70

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530391003  645 LDGAATPVA-----------LR-----GLASDLGFLQGPGAVRIllaeNFTGCLGRVALGGLPL 692
Cdd:pfam00054  71 VDGEARPTGesplgattdldVDgplyvGGLPSLGVKKRRLAISP----SFDGCIRDVIVNGKPL 130
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 479-509 1.74e-06

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 45.07  E-value: 1.74e-06
                          10        20        30
                  ....*....|....*....|....*....|.
gi 530391003  479 CSPDPCFNGGTCLVTWNDFHCTCPANFTGPT 509
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 728-758 3.00e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.90  E-value: 3.00e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 530391003  728 CAPSPCLHDGACRDLFDAFACACGPGWEGPR 758
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 281-308 1.24e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 1.24e-03
                         10        20
                 ....*....|....*....|....*...
gi 530391003 281 PCVHGGSCVDLWTHFRCDCARPHRGPTC 308
Cdd:cd00054   10 PCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
 
Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 133-256 1.72e-11

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 62.44  E-value: 1.72e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391003  133 FRTTLPAGTL-ATRNDTKESLELALVAATLQATLwSYSTTVLVLRLPDLALNDGHWHQVEVVLHLATLELRLwhEGCPAR 211
Cdd:pfam02210   1 FRTRQPNGLLlYAGGGGSDFLALELVNGRLVLRY-DLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSV--DGQTVV 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 530391003  212 LCVASGPVALAST-------ASATPLPAGISSAQLGdatFAGCLQDVRVDGH 256
Cdd:pfam02210  78 SSLPPGESLLLNLngplylgGLPPLLLLPALPVRAG---FVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 321-441 7.66e-11

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 61.28  E-value: 7.66e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391003 321 GAPSSASFLLQELPGPNLTVSFLLRTRESAGLLLQFANDSAAG-LTVFLSEGRIRAEV-PGSPAVVLP-------GRWD- 390
Cdd:cd00110    5 SGSSYVRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGGDfLALELEDGRLVLRYdLGSGSLVLSsktplndGQWHs 84

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 530391003 391 --------------DGLRHLVMLSFGPDQLQDLGQHVHVGG--RLLAADSQPWGGPFRGCLQDLRLD 441
Cdd:cd00110   85 vsverngrsvtlsvDGERVVESGSPGGSALLNLDGPLYLGGlpEDLKSPGLPVSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
129-256 4.84e-10

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 58.50  E-value: 4.84e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391003   129 LALRFRTTLPAGTL--ATRNDTKESLELALVAATLQATlWSYSTTVLVLRLPDLALNDGHWHQVEVVLHLATLELRLwhE 206
Cdd:smart00282   2 ISFSFRTTSPNGLLlyAGSKGGGDYLALELRDGRLVLR-YDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSV--D 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 530391003   207 GCPARLCVASGPVALASTasATPL-----PAGISSAQLGDAT-FAGCLQDVRVDGH 256
Cdd:smart00282  79 GGNRVSGESPGGLTILNL--DGPLylgglPEDLKLPPLPVTPgFRGCIRNLKVNGK 132
LamG smart00282
Laminin G domain;
339-442 1.46e-09

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 56.96  E-value: 1.46e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391003   339 TVSFLLRTRESAGLLlqFANDSAAG---LTVFLSEGRIRAEV-PGSPAVVL--------PGRWD---------------D 391
Cdd:smart00282   1 SISFSFRTTSPNGLL--LYAGSKGGgdyLALELRDGRLVLRYdLGSGPARLtsdptplnDGQWHrvaverngrsvtlsvD 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 530391003   392 GLRHLVMLSFGPDQLQDLGQHVHVGG--RLLAADSQPWGGPFRGCLQDLRLDG 442
Cdd:smart00282  79 GGNRVSGESPGGLTILNLDGPLYLGGlpEDLKLPPLPVTPGFRGCIRNLKVNG 131
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 344-442 3.71e-09

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 55.50  E-value: 3.71e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391003  344 LRTRESAGLLLQFANDSAAGLTVFLSEGRIRAEV--PGSPAVVLP-------GRW----------------DDGLRHLVM 398
Cdd:pfam02210   1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYdlGSGPESLLSsgknlndGQWhsvrverngntltlsvDGQTVVSSL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 530391003  399 LSFGPDQLqDLGQHVHVGG--RLLAADSQPWGGPFRGCLQDLRLDG 442
Cdd:pfam02210  81 PPGESLLL-NLNGPLYLGGlpPLLLLPALPVRAGFVGCIRDVRVNG 125
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 26-61 5.80e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.56  E-value: 5.80e-08
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 530391003  26 DVDECLS-DPCLHGGTCSDTVAGYICRCPETWGGRDC 61
Cdd:cd00054    1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
26-61 3.27e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 47.24  E-value: 3.27e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 530391003    26 DVDECLS-DPCLHGGTCSDTVAGYICRCPETW-GGRDC 61
Cdd:smart00179   1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYtDGRNC 38
Laminin_G_1 pfam00054
Laminin G domain;
568-692 4.40e-07

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 50.01  E-value: 4.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391003  568 FRTRDSEAWLLrAAAGALEGVWLAV--RNGSLAGGVRGGHGLpgAVLPIPgPRVADGAWHRVRLAMERpaattsRWL-LW 644
Cdd:pfam00054   1 FRTTEPSGLLL-YNGTQTERDFLALelRDGRLEVSYDLGSGA--AVVRSG-DKLNDGKWHSVELERNG------RSGtLS 70

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530391003  645 LDGAATPVA-----------LR-----GLASDLGFLQGPGAVRIllaeNFTGCLGRVALGGLPL 692
Cdd:pfam00054  71 VDGEARPTGesplgattdldVDgplyvGGLPSLGVKKRRLAISP----SFDGCIRDVIVNGKPL 130
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 129-254 1.36e-06

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 48.95  E-value: 1.36e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391003 129 LALRFRTTLPAGTL--ATRNDTKESLELALVAATLQATLwSYSTTVLVLRLPDLaLNDGHWHQVEVVLHLATLELRLwhE 206
Cdd:cd00110   24 ISFSFRTTSPNGLLlyAGSQNGGDFLALELEDGRLVLRY-DLGSGSLVLSSKTP-LNDGQWHSVSVERNGRSVTLSV--D 99

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 530391003 207 GCP-ARLCVASGPVALASTasaTPL-----PAGISSAQLGDAT-FAGCLQDVRVD 254
Cdd:cd00110  100 GERvVESGSPGGSALLNLD---GPLylgglPEDLKSPGLPVSPgFVGCIRDLKVN 151
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 479-509 1.74e-06

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 45.07  E-value: 1.74e-06
                          10        20        30
                  ....*....|....*....|....*....|.
gi 530391003  479 CSPDPCFNGGTCLVTWNDFHCTCPANFTGPT 509
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 540-685 1.93e-06

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 48.57  E-value: 1.93e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391003 540 ATFREGPPAAFSGHNASSGRLlgGLSLAFRTRDSEAWLLRAAaGALEGVWLAV--RNGSLAGGVRGGHGlpGAVLPiPGP 617
Cdd:cd00110    2 VSFSGSSYVRLPTLPAPRTRL--SISFSFRTTSPNGLLLYAG-SQNGGDFLALelEDGRLVLRYDLGSG--SLVLS-SKT 75

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530391003 618 RVADGAWHRVRLAMERPAATtsrwlLWLDGAATPVALRGLASDLGFLQGP---GAV-------RILLAENFTGCLGRV 685
Cdd:cd00110   76 PLNDGQWHSVSVERNGRSVT-----LSVDGERVVESGSPGGSALLNLDGPlylGGLpedlkspGLPVSPGFVGCIRDL 148
LamG smart00282
Laminin G domain;
564-689 1.99e-06

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 48.10  E-value: 1.99e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391003   564 LSLAFRTRDSEAWLLRAAaGALEGVWLAV--RNGSLAGGVRGGHGLpgAVLPIPGPRVADGAWHRVRLAMERPAATtsrw 641
Cdd:smart00282   2 ISFSFRTTSPNGLLLYAG-SKGGGDYLALelRDGRLVLRYDLGSGP--ARLTSDPTPLNDGQWHRVAVERNGRSVT---- 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 530391003   642 lLWLDGAATPVALRGLASDLGFLQGP---GAV-------RILLAENFTGCLGRVALGG 689
Cdd:smart00282  75 -LSVDGGNRVSGESPGGLTILNLDGPlylGGLpedlklpPLPVTPGFRGCIRNLKVNG 131
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 480-510 3.07e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 3.07e-06
                         10        20        30
                 ....*....|....*....|....*....|.
gi 530391003 480 SPDPCFNGGTCLVTWNDFHCTCPANFTGPTC 510
Cdd:cd00054    7 SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 30-60 1.63e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.67  E-value: 1.63e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 530391003   30 CLSDPCLHGGTCSDTVAGYICRCPETWGGRD 60
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 728-758 3.00e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.90  E-value: 3.00e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 530391003  728 CAPSPCLHDGACRDLFDAFACACGPGWEGPR 758
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 728-760 5.12e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 5.12e-04
                         10        20        30
                 ....*....|....*....|....*....|....
gi 530391003 728 CA-PSPCLHDGACRDLFDAFACACGPGWEGPRCE 760
Cdd:cd00054    5 CAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
480-510 9.39e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 9.39e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 530391003   480 SPDPCFNGGTCLVTWNDFHCTCPANFT-GPTC 510
Cdd:smart00179   7 SGNPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 281-308 1.24e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 1.24e-03
                         10        20
                 ....*....|....*....|....*...
gi 530391003 281 PCVHGGSCVDLWTHFRCDCARPHRGPTC 308
Cdd:cd00054   10 PCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 277-307 1.85e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.59  E-value: 1.85e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 530391003  277 CRPLPCVHGGSCVDLWTHFRCDCARPHRGPT 307
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
 
Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 133-256 1.72e-11

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 62.44  E-value: 1.72e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391003  133 FRTTLPAGTL-ATRNDTKESLELALVAATLQATLwSYSTTVLVLRLPDLALNDGHWHQVEVVLHLATLELRLwhEGCPAR 211
Cdd:pfam02210   1 FRTRQPNGLLlYAGGGGSDFLALELVNGRLVLRY-DLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSV--DGQTVV 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 530391003  212 LCVASGPVALAST-------ASATPLPAGISSAQLGdatFAGCLQDVRVDGH 256
Cdd:pfam02210  78 SSLPPGESLLLNLngplylgGLPPLLLLPALPVRAG---FVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 321-441 7.66e-11

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 61.28  E-value: 7.66e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391003 321 GAPSSASFLLQELPGPNLTVSFLLRTRESAGLLLQFANDSAAG-LTVFLSEGRIRAEV-PGSPAVVLP-------GRWD- 390
Cdd:cd00110    5 SGSSYVRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGGDfLALELEDGRLVLRYdLGSGSLVLSsktplndGQWHs 84

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 530391003 391 --------------DGLRHLVMLSFGPDQLQDLGQHVHVGG--RLLAADSQPWGGPFRGCLQDLRLD 441
Cdd:cd00110   85 vsverngrsvtlsvDGERVVESGSPGGSALLNLDGPLYLGGlpEDLKSPGLPVSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
129-256 4.84e-10

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 58.50  E-value: 4.84e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391003   129 LALRFRTTLPAGTL--ATRNDTKESLELALVAATLQATlWSYSTTVLVLRLPDLALNDGHWHQVEVVLHLATLELRLwhE 206
Cdd:smart00282   2 ISFSFRTTSPNGLLlyAGSKGGGDYLALELRDGRLVLR-YDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSV--D 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 530391003   207 GCPARLCVASGPVALASTasATPL-----PAGISSAQLGDAT-FAGCLQDVRVDGH 256
Cdd:smart00282  79 GGNRVSGESPGGLTILNL--DGPLylgglPEDLKLPPLPVTPgFRGCIRNLKVNGK 132
LamG smart00282
Laminin G domain;
339-442 1.46e-09

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 56.96  E-value: 1.46e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391003   339 TVSFLLRTRESAGLLlqFANDSAAG---LTVFLSEGRIRAEV-PGSPAVVL--------PGRWD---------------D 391
Cdd:smart00282   1 SISFSFRTTSPNGLL--LYAGSKGGgdyLALELRDGRLVLRYdLGSGPARLtsdptplnDGQWHrvaverngrsvtlsvD 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 530391003   392 GLRHLVMLSFGPDQLQDLGQHVHVGG--RLLAADSQPWGGPFRGCLQDLRLDG 442
Cdd:smart00282  79 GGNRVSGESPGGLTILNLDGPLYLGGlpEDLKLPPLPVTPGFRGCIRNLKVNG 131
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 344-442 3.71e-09

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 55.50  E-value: 3.71e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391003  344 LRTRESAGLLLQFANDSAAGLTVFLSEGRIRAEV--PGSPAVVLP-------GRW----------------DDGLRHLVM 398
Cdd:pfam02210   1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYdlGSGPESLLSsgknlndGQWhsvrverngntltlsvDGQTVVSSL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 530391003  399 LSFGPDQLqDLGQHVHVGG--RLLAADSQPWGGPFRGCLQDLRLDG 442
Cdd:pfam02210  81 PPGESLLL-NLNGPLYLGGlpPLLLLPALPVRAGFVGCIRDVRVNG 125
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 26-61 5.80e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.56  E-value: 5.80e-08
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 530391003  26 DVDECLS-DPCLHGGTCSDTVAGYICRCPETWGGRDC 61
Cdd:cd00054    1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
26-61 3.27e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 47.24  E-value: 3.27e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 530391003    26 DVDECLS-DPCLHGGTCSDTVAGYICRCPETW-GGRDC 61
Cdd:smart00179   1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYtDGRNC 38
Laminin_G_1 pfam00054
Laminin G domain;
568-692 4.40e-07

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 50.01  E-value: 4.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391003  568 FRTRDSEAWLLrAAAGALEGVWLAV--RNGSLAGGVRGGHGLpgAVLPIPgPRVADGAWHRVRLAMERpaattsRWL-LW 644
Cdd:pfam00054   1 FRTTEPSGLLL-YNGTQTERDFLALelRDGRLEVSYDLGSGA--AVVRSG-DKLNDGKWHSVELERNG------RSGtLS 70

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530391003  645 LDGAATPVA-----------LR-----GLASDLGFLQGPGAVRIllaeNFTGCLGRVALGGLPL 692
Cdd:pfam00054  71 VDGEARPTGesplgattdldVDgplyvGGLPSLGVKKRRLAISP----SFDGCIRDVIVNGKPL 130
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 129-254 1.36e-06

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 48.95  E-value: 1.36e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391003 129 LALRFRTTLPAGTL--ATRNDTKESLELALVAATLQATLwSYSTTVLVLRLPDLaLNDGHWHQVEVVLHLATLELRLwhE 206
Cdd:cd00110   24 ISFSFRTTSPNGLLlyAGSQNGGDFLALELEDGRLVLRY-DLGSGSLVLSSKTP-LNDGQWHSVSVERNGRSVTLSV--D 99

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 530391003 207 GCP-ARLCVASGPVALASTasaTPL-----PAGISSAQLGDAT-FAGCLQDVRVD 254
Cdd:cd00110  100 GERvVESGSPGGSALLNLD---GPLylgglPEDLKSPGLPVSPgFVGCIRDLKVN 151
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 479-509 1.74e-06

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 45.07  E-value: 1.74e-06
                          10        20        30
                  ....*....|....*....|....*....|.
gi 530391003  479 CSPDPCFNGGTCLVTWNDFHCTCPANFTGPT 509
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 540-685 1.93e-06

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 48.57  E-value: 1.93e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391003 540 ATFREGPPAAFSGHNASSGRLlgGLSLAFRTRDSEAWLLRAAaGALEGVWLAV--RNGSLAGGVRGGHGlpGAVLPiPGP 617
Cdd:cd00110    2 VSFSGSSYVRLPTLPAPRTRL--SISFSFRTTSPNGLLLYAG-SQNGGDFLALelEDGRLVLRYDLGSG--SLVLS-SKT 75

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530391003 618 RVADGAWHRVRLAMERPAATtsrwlLWLDGAATPVALRGLASDLGFLQGP---GAV-------RILLAENFTGCLGRV 685
Cdd:cd00110   76 PLNDGQWHSVSVERNGRSVT-----LSVDGERVVESGSPGGSALLNLDGPlylGGLpedlkspGLPVSPGFVGCIRDL 148
LamG smart00282
Laminin G domain;
564-689 1.99e-06

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 48.10  E-value: 1.99e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391003   564 LSLAFRTRDSEAWLLRAAaGALEGVWLAV--RNGSLAGGVRGGHGLpgAVLPIPGPRVADGAWHRVRLAMERPAATtsrw 641
Cdd:smart00282   2 ISFSFRTTSPNGLLLYAG-SKGGGDYLALelRDGRLVLRYDLGSGP--ARLTSDPTPLNDGQWHRVAVERNGRSVT---- 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 530391003   642 lLWLDGAATPVALRGLASDLGFLQGP---GAV-------RILLAENFTGCLGRVALGG 689
Cdd:smart00282  75 -LSVDGGNRVSGESPGGLTILNLDGPlylGGLpedlklpPLPVTPGFRGCIRNLKVNG 131
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 480-510 3.07e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 3.07e-06
                         10        20        30
                 ....*....|....*....|....*....|.
gi 530391003 480 SPDPCFNGGTCLVTWNDFHCTCPANFTGPTC 510
Cdd:cd00054    7 SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
Laminin_G_1 pfam00054
Laminin G domain;
133-259 3.37e-06

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 47.31  E-value: 3.37e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391003  133 FRTTLPAGTLAT--RNDTKESLELALVAATLQaTLWSYSTTVLVLRLPDLaLNDGHWHQVEVVL--HLATLELRlwheGC 208
Cdd:pfam00054   1 FRTTEPSGLLLYngTQTERDFLALELRDGRLE-VSYDLGSGAAVVRSGDK-LNDGKWHSVELERngRSGTLSVD----GE 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530391003  209 pARLCVAS--GP-----------VALASTASATPLPAGISSAqlgdatFAGCLQDVRVDGHLLL 259
Cdd:pfam00054  75 -ARPTGESplGAttdldvdgplyVGGLPSLGVKKRRLAISPS------FDGCIRDVIVNGKPLD 131
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 568-689 1.12e-05

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 45.87  E-value: 1.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391003  568 FRTRDSEAWLLRAAAGALEGVWLAVRNGSLAGGVRGGHGLPGAVlpIPGPRVADGAWHRVRLAMERPAATtsrwlLWLDG 647
Cdd:pfam02210   1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLGSGPESLL--SSGKNLNDGQWHSVRVERNGNTLT-----LSVDG 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 530391003  648 AATPVALRGLASDLGFLQGP---GAVRILLA-------ENFTGCLGRVALGG 689
Cdd:pfam02210  74 QTVVSSLPPGESLLLNLNGPlylGGLPPLLLlpalpvrAGFVGCIRDVRVNG 125
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 30-60 1.63e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.67  E-value: 1.63e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 530391003   30 CLSDPCLHGGTCSDTVAGYICRCPETWGGRD 60
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 728-758 3.00e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.90  E-value: 3.00e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 530391003  728 CAPSPCLHDGACRDLFDAFACACGPGWEGPR 758
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 728-760 5.12e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 5.12e-04
                         10        20        30
                 ....*....|....*....|....*....|....
gi 530391003 728 CA-PSPCLHDGACRDLFDAFACACGPGWEGPRCE 760
Cdd:cd00054    5 CAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
480-510 9.39e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 9.39e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 530391003   480 SPDPCFNGGTCLVTWNDFHCTCPANFT-GPTC 510
Cdd:smart00179   7 SGNPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 480-509 1.10e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 37.46  E-value: 1.10e-03
                         10        20        30
                 ....*....|....*....|....*....|
gi 530391003 480 SPDPCFNGGTCLVTWNDFHCTCPANFTGPT 509
Cdd:cd00053    4 ASNPCSNGGTCVNTPGSYRCVCPPGYTGDR 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 281-308 1.24e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 1.24e-03
                         10        20
                 ....*....|....*....|....*...
gi 530391003 281 PCVHGGSCVDLWTHFRCDCARPHRGPTC 308
Cdd:cd00054   10 PCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 277-307 1.85e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.59  E-value: 1.85e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 530391003  277 CRPLPCVHGGSCVDLWTHFRCDCARPHRGPT 307
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 29-59 1.97e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 36.69  E-value: 1.97e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 530391003  29 EC-LSDPCLHGGTCSDTVAGYICRCPETWGGR 59
Cdd:cd00053    1 ECaASNPCSNGGTCVNTPGSYRCVCPPGYTGD 32
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 35-56 6.61e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 35.00  E-value: 6.61e-03
                          10        20
                  ....*....|....*....|..
gi 530391003   35 CLHGGTCSDTVAGYICRCPETW 56
Cdd:pfam12661   1 CQNGGTCVDGVNGYKCQCPPGY 22
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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