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Conserved domains on  [gi|530391261|ref|XP_005252117|]
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TBC1 domain family member 13 isoform X2 [Homo sapiens]

Protein Classification

TBC domain-containing protein( domain architecture ID 10640016)

TBC (Tre-2/Bub2/Cdc1) domain-containing protein may function as a GTPase activator protein of Rab-like small GTPases

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TBC smart00164
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and ...
28-291 1.57e-37

Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases.


:

Pssm-ID: 214540 [Multi-domain]  Cd Length: 216  Bit Score: 133.20  E-value: 1.57e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391261    28 PNPDSRWNTYF---------KDNEVLLQIDKDVRRLCPDISFFQratdypcllildpqnefetlrkrveqttlksqtvar 98
Cdd:smart00164  22 PMDTSADKDLYsrllketapDDKSIVHQIEKDLRRTFPEHSFFQ------------------------------------ 65
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391261    99 nrsgvtnmsspHKNSVpsslneyevlpngceaHWEVVERILFIYAKLNPGIAYVQGMNEIVGPLYYTFatdpnsewkeHA 178
Cdd:smart00164  66 -----------DKEGP----------------GQESLRRVLKAYALYNPEVGYCQGMNFLAAPLLLVM----------ED 108
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391261   179 EADTFFCFTNLMAEIRDNFIKsldDSQCGITYKMEKVYSTLKDKDVELYLKLQEQNIKPQFFAFRWLTLLLSQEFLLPDV 258
Cdd:smart00164 109 EEDAFWCLVKLMERYGPNFYL---PDMSGLQLDLLQLDRLVKEYDPDLYKHLKDLGITPSLYALRWFLTLFARELPLEIV 185
                          250       260       270
                   ....*....|....*....|....*....|...
gi 530391261   259 IRIWDSLFADdnRFDFLLLVCCAMLMLIREQLL 291
Cdd:smart00164 186 LRIWDVLFAE--GSDFLFRVALALLKLHRDVLL 216
 
Name Accession Description Interval E-value
TBC smart00164
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and ...
28-291 1.57e-37

Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases.


Pssm-ID: 214540 [Multi-domain]  Cd Length: 216  Bit Score: 133.20  E-value: 1.57e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391261    28 PNPDSRWNTYF---------KDNEVLLQIDKDVRRLCPDISFFQratdypcllildpqnefetlrkrveqttlksqtvar 98
Cdd:smart00164  22 PMDTSADKDLYsrllketapDDKSIVHQIEKDLRRTFPEHSFFQ------------------------------------ 65
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391261    99 nrsgvtnmsspHKNSVpsslneyevlpngceaHWEVVERILFIYAKLNPGIAYVQGMNEIVGPLYYTFatdpnsewkeHA 178
Cdd:smart00164  66 -----------DKEGP----------------GQESLRRVLKAYALYNPEVGYCQGMNFLAAPLLLVM----------ED 108
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391261   179 EADTFFCFTNLMAEIRDNFIKsldDSQCGITYKMEKVYSTLKDKDVELYLKLQEQNIKPQFFAFRWLTLLLSQEFLLPDV 258
Cdd:smart00164 109 EEDAFWCLVKLMERYGPNFYL---PDMSGLQLDLLQLDRLVKEYDPDLYKHLKDLGITPSLYALRWFLTLFARELPLEIV 185
                          250       260       270
                   ....*....|....*....|....*....|...
gi 530391261   259 IRIWDSLFADdnRFDFLLLVCCAMLMLIREQLL 291
Cdd:smart00164 186 LRIWDVLFAE--GSDFLFRVALALLKLHRDVLL 216
RabGAP-TBC pfam00566
Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are ...
133-291 1.73e-33

Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.


Pssm-ID: 459855  Cd Length: 178  Bit Score: 121.59  E-value: 1.73e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391261  133 EVVERILFIYAKLNPGIAYVQGMNEIVGPLYYTFATdpnsewkehaEADTFFCFTNLMAE--IRDNFIKSLDDSQCGItY 210
Cdd:pfam00566  33 NSLRRILKAYSIYNPDVGYCQGMNFIAAPLLLVYLD----------EEDAFWCFVSLLENylLRDFYTPDFPGLKRDL-Y 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391261  211 KMEKVystLKDKDVELYLKLQEQNIKPQFFAFRWLTLLLSQEFLLPDVIRIWDSLFADDNRFdFLLLVCCAMLMLIREQL 290
Cdd:pfam00566 102 VFEEL---LKKKLPKLYKHLKELGLDPDLFASQWFLTLFAREFPLSTVLRIWDYFFLEGEKF-VLFRVALAILKRFREEL 177

                  .
gi 530391261  291 L 291
Cdd:pfam00566 178 L 178
COG5210 COG5210
GTPase-activating protein [General function prediction only];
133-322 1.17e-24

GTPase-activating protein [General function prediction only];


Pssm-ID: 227535 [Multi-domain]  Cd Length: 496  Bit Score: 103.73  E-value: 1.17e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391261 133 EVVERILFIYAKLNPGIAYVQGMNEIVGPLYYTFATdpnsewkehaEADTFFCFTNLM--AEIRDNFIKSlddsQCGITY 210
Cdd:COG5210  283 ENLRRVLKAYSLYNPEVGYVQGMNFLAAPLLLVLES----------EEQAFWCLVKLLknYGLPGYFLKN----LSGLHR 348
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391261 211 KMEKVYSTLKDKDVELYLKLQEQNIKPQFFAFRWLTLLLSQEFLLPDVIRIWDSLFADDNRFDFLLLVccAMLMLIREQL 290
Cdd:COG5210  349 DLKVLDDLVEELDPELYEHLLREGVVLLMFAFRWFLTLFVREFPLEYALRIWDCLFLEGSSMLFQLAL--AILKLLRDKL 426
                        170       180       190
                 ....*....|....*....|....*....|..
gi 530391261 291 LEGDFTVNMRLLQDYPITDVCQILQKAKELQD 322
Cdd:COG5210  427 LKLDSDELLDLLLKQLFLHSGKEAWSSILKFR 458
 
Name Accession Description Interval E-value
TBC smart00164
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and ...
28-291 1.57e-37

Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases.


Pssm-ID: 214540 [Multi-domain]  Cd Length: 216  Bit Score: 133.20  E-value: 1.57e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391261    28 PNPDSRWNTYF---------KDNEVLLQIDKDVRRLCPDISFFQratdypcllildpqnefetlrkrveqttlksqtvar 98
Cdd:smart00164  22 PMDTSADKDLYsrllketapDDKSIVHQIEKDLRRTFPEHSFFQ------------------------------------ 65
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391261    99 nrsgvtnmsspHKNSVpsslneyevlpngceaHWEVVERILFIYAKLNPGIAYVQGMNEIVGPLYYTFatdpnsewkeHA 178
Cdd:smart00164  66 -----------DKEGP----------------GQESLRRVLKAYALYNPEVGYCQGMNFLAAPLLLVM----------ED 108
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391261   179 EADTFFCFTNLMAEIRDNFIKsldDSQCGITYKMEKVYSTLKDKDVELYLKLQEQNIKPQFFAFRWLTLLLSQEFLLPDV 258
Cdd:smart00164 109 EEDAFWCLVKLMERYGPNFYL---PDMSGLQLDLLQLDRLVKEYDPDLYKHLKDLGITPSLYALRWFLTLFARELPLEIV 185
                          250       260       270
                   ....*....|....*....|....*....|...
gi 530391261   259 IRIWDSLFADdnRFDFLLLVCCAMLMLIREQLL 291
Cdd:smart00164 186 LRIWDVLFAE--GSDFLFRVALALLKLHRDVLL 216
RabGAP-TBC pfam00566
Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are ...
133-291 1.73e-33

Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.


Pssm-ID: 459855  Cd Length: 178  Bit Score: 121.59  E-value: 1.73e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391261  133 EVVERILFIYAKLNPGIAYVQGMNEIVGPLYYTFATdpnsewkehaEADTFFCFTNLMAE--IRDNFIKSLDDSQCGItY 210
Cdd:pfam00566  33 NSLRRILKAYSIYNPDVGYCQGMNFIAAPLLLVYLD----------EEDAFWCFVSLLENylLRDFYTPDFPGLKRDL-Y 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391261  211 KMEKVystLKDKDVELYLKLQEQNIKPQFFAFRWLTLLLSQEFLLPDVIRIWDSLFADDNRFdFLLLVCCAMLMLIREQL 290
Cdd:pfam00566 102 VFEEL---LKKKLPKLYKHLKELGLDPDLFASQWFLTLFAREFPLSTVLRIWDYFFLEGEKF-VLFRVALAILKRFREEL 177

                  .
gi 530391261  291 L 291
Cdd:pfam00566 178 L 178
COG5210 COG5210
GTPase-activating protein [General function prediction only];
133-322 1.17e-24

GTPase-activating protein [General function prediction only];


Pssm-ID: 227535 [Multi-domain]  Cd Length: 496  Bit Score: 103.73  E-value: 1.17e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391261 133 EVVERILFIYAKLNPGIAYVQGMNEIVGPLYYTFATdpnsewkehaEADTFFCFTNLM--AEIRDNFIKSlddsQCGITY 210
Cdd:COG5210  283 ENLRRVLKAYSLYNPEVGYVQGMNFLAAPLLLVLES----------EEQAFWCLVKLLknYGLPGYFLKN----LSGLHR 348
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391261 211 KMEKVYSTLKDKDVELYLKLQEQNIKPQFFAFRWLTLLLSQEFLLPDVIRIWDSLFADDNRFDFLLLVccAMLMLIREQL 290
Cdd:COG5210  349 DLKVLDDLVEELDPELYEHLLREGVVLLMFAFRWFLTLFVREFPLEYALRIWDCLFLEGSSMLFQLAL--AILKLLRDKL 426
                        170       180       190
                 ....*....|....*....|....*....|..
gi 530391261 291 LEGDFTVNMRLLQDYPITDVCQILQKAKELQD 322
Cdd:COG5210  427 LKLDSDELLDLLLKQLFLHSGKEAWSSILKFR 458
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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