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Conserved domains on  [gi|530391279|ref|XP_005252126|]
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methylglutaconyl-CoA hydratase, mitochondrial isoform X5 [Homo sapiens]

Protein Classification

Clp protease/crotonase-like domain-containing protein( domain architecture ID 581041)

Clp protease/crotonase-like domain-containing protein similar to Oryza sativa enoyl-CoA delta isomerase which plays a role in fatty acid metabolism, which involves stabilization of an enolate anion intermediate derived from an acyl-CoA substrate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
crotonase-like super family cl23717
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse ...
 99-287 3.67e-56

Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.


The actual alignment was detected with superfamily member PLN02600:

Pssm-ID: 474030 [Multi-domain]  Cd Length: 251  Bit Score: 181.93  E-value: 3.67e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279  99 IVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLKERAKMSSSEVGPFVSKIRAVINDI 178
Cdd:PLN02600   5 IVELRLDRPEAKNAIGKEMLRGLRSAFEKIQADASARVVMLRSSVPGVFCAGADLKERRKMSPSEVQKFVNSLRSTFSSL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 179 ANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVLDGKEA 258
Cdd:PLN02600  85 EALSIPTIAVVEGAALGGGLELALSCDLRICGEEAVFGLPETGLAIIPGAGGTQRLPRLVGRSRAKELIFTGRRIGAREA 164

                        170       180
                 ....*....|....*....|....*....
gi 530391279 259 KAVGLISHVLeqnQEGDaAYRKALDLARE 287
Cdd:PLN02600 165 ASMGLVNYCV---PAGE-AYEKALELAQE 189
 
Name Accession Description Interval E-value
PLN02600 PLN02600
enoyl-CoA hydratase
 99-287 3.67e-56

enoyl-CoA hydratase


Pssm-ID: 178210 [Multi-domain]  Cd Length: 251  Bit Score: 181.93  E-value: 3.67e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279  99 IVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLKERAKMSSSEVGPFVSKIRAVINDI 178
Cdd:PLN02600   5 IVELRLDRPEAKNAIGKEMLRGLRSAFEKIQADASARVVMLRSSVPGVFCAGADLKERRKMSPSEVQKFVNSLRSTFSSL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 179 ANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVLDGKEA 258
Cdd:PLN02600  85 EALSIPTIAVVEGAALGGGLELALSCDLRICGEEAVFGLPETGLAIIPGAGGTQRLPRLVGRSRAKELIFTGRRIGAREA 164

                        170       180
                 ....*....|....*....|....*....
gi 530391279 259 KAVGLISHVLeqnQEGDaAYRKALDLARE 287
Cdd:PLN02600 165 ASMGLVNYCV---PAGE-AYEKALELAQE 189
crotonase-like cd06558
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse ...
 98-287 8.12e-47

Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.


Pssm-ID: 119339 [Multi-domain]  Cd Length: 195  Bit Score: 155.80  E-value: 8.12e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279  98 RIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEvPGIFCAGADLKERAKMSSS--EVGPFVSKIRAVI 175
Cdd:cd06558    8 GVATITLNRPEKRNALSLEMLDELAAALDEAEADPDVRVVVLTGA-GKAFCAGADLKELAALSDAgeEARAFIRELQELL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 176 NDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVLDG 255
Cdd:cd06558   87 RALLRLPKPVIAAVNGAALGGGLELALACDIRIAAEDAKFGLPEVKLGLVPGGGGTQRLPRLVGPARARELLLTGRRISA 166

                        170       180       190
                 ....*....|....*....|....*....|..
gi 530391279 256 KEAKAVGLISHVLEQnqegDAAYRKALDLARE 287
Cdd:cd06558  167 EEALELGLVDEVVPD----EELLAAALELARR 194
CaiD COG1024
Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase ...
 98-286 5.14e-45

Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase/carnithine racemase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440647 [Multi-domain]  Cd Length: 249  Bit Score: 153.01  E-value: 5.14e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279  98 RIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEvPGIFCAGADLKE-RAKMSSSEVGPFVSKIRAVIN 176
Cdd:COG1024    8 GVATITLNRPEKLNALSLEMLAELAAALDEAEADPDVRVVVLTGA-GKAFCAGADLKElAAAADPEEARAFARGLQRLFR 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 177 DIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVLDGK 256
Cdd:COG1024   87 ALRRLPKPVIAAVNGAALGGGLELALACDLRIAAEDARFGLPEVRLGLIPGGGGTQRLPRLVGLARAKELLLTGRRIDAE 166

                        170       180       190
                 ....*....|....*....|....*....|
gi 530391279 257 EAKAVGLISHVLEQNQEGDAAYRKALDLAR 286
Cdd:COG1024  167 EALELGLVNRVVPDDELLAAALALAARLAA 196
ECH_1 pfam00378
Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: ...
 99-289 6.44e-31

Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase.


Pssm-ID: 395302 [Multi-domain]  Cd Length: 251  Bit Score: 116.31  E-value: 6.44e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279   99 IVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSeVPGIFCAGADLKERAKMSSSEVGPFVSKIRAVINDI 178
Cdd:pfam00378   6 VAVITLNRPEAVNALSAELITELIQALEKLRTDPSVRAVVLTG-GDKAFCAGADLKEMYGEGPAHQALYRENVLDLWTLL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279  179 ANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVLDGKEA 258
Cdd:pfam00378  85 YTCPKPVIAAVNGYAIGGGCELALACDIIIAADNASFGLNETKLGIIPGAGGTDRLPRIIGHSKAMEMLLLGRRISAQEA 164

                         170       180       190
                  ....*....|....*....|....*....|.
gi 530391279  259 KAVGLISHVLEQNQegdaAYRKALDLAREFL 289
Cdd:pfam00378 165 LKWGLVDKVVPEDQ----LLDEARELAEKLA 191
fa_ox_alpha_mit TIGR02441
fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of ...
 99-269 1.36e-17

fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of mitochondrial multifunctional fatty acid degradation enzyme complex. Subunit activities include: enoyl-CoA hydratase (EC 4.2.1.17) _ 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35). Some characterization in human (SP:P40939), pig (SP:Q29554), and rat (SP:Q64428). The beta subunit has activity: acetyl-CoA C-acyltransferase (EC 2.3.1.16).


Pssm-ID: 131494 [Multi-domain]  Cd Length: 737  Bit Score: 82.96  E-value: 1.36e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279   99 IVVLGINRAYGK-NSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLKE-RAKMSSSEVGPFVSKIRAVIN 176
Cdd:TIGR02441  23 VAVVKIDSPNSKvNTLSKELFAEFKEVMNELWTNEAIKSAVLISGKPGSFVAGADIQMiAACKTAQEVTQLSQEGQEMFE 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279  177 DIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAK--MGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVLD 254
Cdd:TIGR02441 103 RIEKSQKPIVAAISGSCLGGGLELALACHYRIATKDRKtlLGLPEVMLGLLPGAGGTQRLPKLTGVPAALDMMLTGKKIR 182

                         170
                  ....*....|....*
gi 530391279  255 GKEAKAVGLISHVLE 269
Cdd:TIGR02441 183 ADRAKKMGIVDQLVD 197
 
Name Accession Description Interval E-value
PLN02600 PLN02600
enoyl-CoA hydratase
 99-287 3.67e-56

enoyl-CoA hydratase


Pssm-ID: 178210 [Multi-domain]  Cd Length: 251  Bit Score: 181.93  E-value: 3.67e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279  99 IVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLKERAKMSSSEVGPFVSKIRAVINDI 178
Cdd:PLN02600   5 IVELRLDRPEAKNAIGKEMLRGLRSAFEKIQADASARVVMLRSSVPGVFCAGADLKERRKMSPSEVQKFVNSLRSTFSSL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 179 ANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVLDGKEA 258
Cdd:PLN02600  85 EALSIPTIAVVEGAALGGGLELALSCDLRICGEEAVFGLPETGLAIIPGAGGTQRLPRLVGRSRAKELIFTGRRIGAREA 164

                        170       180
                 ....*....|....*....|....*....
gi 530391279 259 KAVGLISHVLeqnQEGDaAYRKALDLARE 287
Cdd:PLN02600 165 ASMGLVNYCV---PAGE-AYEKALELAQE 189
PRK07657 PRK07657
enoyl-CoA hydratase; Provisional
 99-286 5.88e-53

enoyl-CoA hydratase; Provisional


Pssm-ID: 181069 [Multi-domain]  Cd Length: 260  Bit Score: 173.77  E-value: 5.88e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279  99 IVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLKERAKMSSSEVGPFVSKIRAVINDI 178
Cdd:PRK07657  14 VVKITLNRPRAANALSLALLEELQNILTQINEEANVRVVILTGAGEKAFCAGADLKERAGMNEEQVRHAVSLIRTTMEMV 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 179 ANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVLDGKEA 258
Cdd:PRK07657  94 EQLPQPVIAAINGIALGGGLELALACDFRIAAESASLGLTETTLAIIPGAGGTQRLPRLIGVGRAKELIYTGRRISAQEA 173

                        170       180
                 ....*....|....*....|....*...
gi 530391279 259 KAVGLISHVLEQNQEGDaayrKALDLAR 286
Cdd:PRK07657 174 KEIGLVEFVVPAHLLEE----KAIEIAE 197
crotonase-like cd06558
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse ...
 98-287 8.12e-47

Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.


Pssm-ID: 119339 [Multi-domain]  Cd Length: 195  Bit Score: 155.80  E-value: 8.12e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279  98 RIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEvPGIFCAGADLKERAKMSSS--EVGPFVSKIRAVI 175
Cdd:cd06558    8 GVATITLNRPEKRNALSLEMLDELAAALDEAEADPDVRVVVLTGA-GKAFCAGADLKELAALSDAgeEARAFIRELQELL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 176 NDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVLDG 255
Cdd:cd06558   87 RALLRLPKPVIAAVNGAALGGGLELALACDIRIAAEDAKFGLPEVKLGLVPGGGGTQRLPRLVGPARARELLLTGRRISA 166

                        170       180       190
                 ....*....|....*....|....*....|..
gi 530391279 256 KEAKAVGLISHVLEQnqegDAAYRKALDLARE 287
Cdd:cd06558  167 EEALELGLVDEVVPD----EELLAAALELARR 194
CaiD COG1024
Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase ...
 98-286 5.14e-45

Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase/carnithine racemase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440647 [Multi-domain]  Cd Length: 249  Bit Score: 153.01  E-value: 5.14e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279  98 RIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEvPGIFCAGADLKE-RAKMSSSEVGPFVSKIRAVIN 176
Cdd:COG1024    8 GVATITLNRPEKLNALSLEMLAELAAALDEAEADPDVRVVVLTGA-GKAFCAGADLKElAAAADPEEARAFARGLQRLFR 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 177 DIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVLDGK 256
Cdd:COG1024   87 ALRRLPKPVIAAVNGAALGGGLELALACDLRIAAEDARFGLPEVRLGLIPGGGGTQRLPRLVGLARAKELLLTGRRIDAE 166

                        170       180       190
                 ....*....|....*....|....*....|
gi 530391279 257 EAKAVGLISHVLEQNQEGDAAYRKALDLAR 286
Cdd:COG1024  167 EALELGLVNRVVPDDELLAAALALAARLAA 196
PRK06688 PRK06688
enoyl-CoA hydratase; Provisional
 98-286 8.36e-34

enoyl-CoA hydratase; Provisional


Pssm-ID: 235852 [Multi-domain]  Cd Length: 259  Bit Score: 123.82  E-value: 8.36e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279  98 RIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSeVPGIFCAGADLKERAKmSSSEVGPFVSKIRAVIND 177
Cdd:PRK06688  14 GVLTITINRPDKKNALTAAMYQALADALEAAATDPAVRVVVLTG-AGRAFSAGGDIKDFPK-APPKPPDELAPVNRFLRA 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 178 IANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVLDGKE 257
Cdd:PRK06688  92 IAALPKPVVAAVNGPAVGVGVSLALACDLVYASESAKFSLPFAKLGLCPDAGGSALLPRLIGRARAAEMLLLGEPLSAEE 171

                        170       180       190
                 ....*....|....*....|....*....|
gi 530391279 258 AKAVGLISHVLEQNqEGDAAYRK-ALDLAR 286
Cdd:PRK06688 172 ALRIGLVNRVVPAA-ELDAEADAqAAKLAA 200
PRK05809 PRK05809
short-chain-enoyl-CoA hydratase;
99-281 2.09e-33

short-chain-enoyl-CoA hydratase;


Pssm-ID: 180270 [Multi-domain]  Cd Length: 260  Bit Score: 122.93  E-value: 2.09e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279  99 IVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLKERAKMSSSEVGPFVSKIRAVINDI 178
Cdd:PRK05809  14 IAVVTINRPKALNALNSETLKELDTVLDDIENDDNVYAVILTGAGEKAFVAGADISEMKDLNEEEGRKFGLLGNKVFRKL 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 179 ANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVLDGKEA 258
Cdd:PRK05809  94 ENLDKPVIAAINGFALGGGCELSMACDIRIASEKAKFGQPEVGLGITPGFGGTQRLARIVGPGKAKELIYTGDMINAEEA 173

                        170       180
                 ....*....|....*....|...
gi 530391279 259 KAVGLISHVLEQNQEGDAAYRKA 281
Cdd:PRK05809 174 LRIGLVNKVVEPEKLMEEAKALA 196
PRK07658 PRK07658
enoyl-CoA hydratase; Provisional
 98-288 1.41e-32

enoyl-CoA hydratase; Provisional


Pssm-ID: 181070 [Multi-domain]  Cd Length: 257  Bit Score: 120.51  E-value: 1.41e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279  98 RIVVLGINRAYGkNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEvpG-IFCAGADLKE-RAKMSSSEVGPFVSKIRAVI 175
Cdd:PRK07658  11 HVAVITLNHPPA-NALSSQVLHELSELLDQVEKDDNVRVVVIHGE--GrFFSAGADIKEfTSVTEAEQATELAQLGQVTF 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 176 NDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVLDG 255
Cdd:PRK07658  88 ERVEKFSKPVIAAIHGAALGGGLELAMSCHIRFATESAKLGLPELNLGLIPGFAGTQRLPRYVGKAKALEMMLTSEPITG 167

                        170       180       190
                 ....*....|....*....|....*....|...
gi 530391279 256 KEAKAVGLISHVLEQNQegdaAYRKALDLAREF 288
Cdd:PRK07658 168 AEALKWGLVNGVFPEET----LLDDAKKLAKKI 196
ECH_1 pfam00378
Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: ...
 99-289 6.44e-31

Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase.


Pssm-ID: 395302 [Multi-domain]  Cd Length: 251  Bit Score: 116.31  E-value: 6.44e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279   99 IVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSeVPGIFCAGADLKERAKMSSSEVGPFVSKIRAVINDI 178
Cdd:pfam00378   6 VAVITLNRPEAVNALSAELITELIQALEKLRTDPSVRAVVLTG-GDKAFCAGADLKEMYGEGPAHQALYRENVLDLWTLL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279  179 ANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVLDGKEA 258
Cdd:pfam00378  85 YTCPKPVIAAVNGYAIGGGCELALACDIIIAADNASFGLNETKLGIIPGAGGTDRLPRIIGHSKAMEMLLLGRRISAQEA 164

                         170       180       190
                  ....*....|....*....|....*....|.
gi 530391279  259 KAVGLISHVLEQNQegdaAYRKALDLAREFL 289
Cdd:pfam00378 165 LKWGLVDKVVPEDQ----LLDEARELAEKLA 191
fadB PRK11730
fatty acid oxidation complex subunit alpha FadB;
111-277 2.57e-27

fatty acid oxidation complex subunit alpha FadB;


Pssm-ID: 183293 [Multi-domain]  Cd Length: 715  Bit Score: 111.49  E-value: 2.57e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 111 NSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPgIFCAGADLKERA---KMSSSEVGPFVSKIRAVINDIANLPVPTIA 187
Cdd:PRK11730  29 NKLDRATLASLGEALDALEAQSDLKGLLLTSAKD-AFIVGADITEFLslfAAPEEELSQWLHFANSIFNRLEDLPVPTVA 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 188 AIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVLDGKEAKAVGLISHV 267
Cdd:PRK11730 108 AINGYALGGGCECVLATDYRVASPDARIGLPETKLGIMPGFGGTVRLPRLIGADNALEWIAAGKDVRAEDALKVGAVDAV 187

                        170
                 ....*....|
gi 530391279 268 LEQNQEGDAA 277
Cdd:PRK11730 188 VAPEKLQEAA 197
PRK08138 PRK08138
enoyl-CoA hydratase; Provisional
 99-287 3.27e-27

enoyl-CoA hydratase; Provisional


Pssm-ID: 236162 [Multi-domain]  Cd Length: 261  Bit Score: 106.67  E-value: 3.27e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279  99 IVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEvPGIFCAGADLKERAKMSSSEVgpFVSKIRAVINDI 178
Cdd:PRK08138  18 VALLRLNRPEARNALNMEVRQQLAEHFTELSEDPDIRAIVLTGG-EKVFAAGADIKEFATAGAIEM--YLRHTERYWEAI 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 179 ANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVLDGKEA 258
Cdd:PRK08138  95 AQCPKPVIAAVNGYALGGGCELAMHADIIVAGESASFGQPEIKVGLMPGAGGTQRLVRAVGKFKAMRMALTGCMVPAPEA 174

                        170       180
                 ....*....|....*....|....*....
gi 530391279 259 KAVGLISHVLEQNQegdaAYRKALDLARE 287
Cdd:PRK08138 175 LAIGLVSEVVEDEQ----TLPRALELARE 199
PRK05862 PRK05862
enoyl-CoA hydratase; Provisional
 98-298 3.39e-27

enoyl-CoA hydratase; Provisional


Pssm-ID: 180295 [Multi-domain]  Cd Length: 257  Bit Score: 106.28  E-value: 3.39e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279  98 RIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIR-SEvpGIFCAGADLKERAKMSSSEVgpFVSKIRAVIN 176
Cdd:PRK05862  13 RVGLITLNRPKALNALNDALMDELGAALAAFDADEGIGAIVITgSE--KAFAAGADIKEMADLSFMDV--YKGDYITNWE 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 177 DIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVLDGK 256
Cdd:PRK05862  89 KVARIRKPVIAAVAGYALGGGCELAMMCDIIIAADTAKFGQPEIKLGVLPGMGGSQRLTRAVGKAKAMDLCLTGRMMDAA 168

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 530391279 257 EAKAVGLISHVLEQNQEGDAAYRKALDLAREFLPQVKQIRRC 298
Cdd:PRK05862 169 EAERAGLVSRVVPADKLLDEALAAATTIASFSLPAVMMAKEA 210
PRK09245 PRK09245
crotonase/enoyl-CoA hydratase family protein;
99-285 5.48e-26

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181723  Cd Length: 266  Bit Score: 103.51  E-value: 5.48e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279  99 IVVLGINRAYGKNSLSKN-LIKMLSKAVDALKSDKKVRTIIIRSEVPgIFCAGADLKE-RAKMSSSEVGPFVSK------ 170
Cdd:PRK09245  13 IVTLTMNRPETRNALSDNdAVDALVAACAAINADRSVRAVILTGAGT-AFSSGGNVKDmRARVGAFGGSPADIRqgyrhg 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 171 IRAVINDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSA 250
Cdd:PRK09245  92 IQRIPLALYNLEVPVIAAVNGPAIGAGCDLACMCDIRIASETARFAESFVKLGLIPGDGGAWLLPRIIGMARAAEMAFTG 171

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 530391279 251 RVLDGKEAKAVGLISHVLEQNQEGDAAYRKALDLA 285
Cdd:PRK09245 172 DAIDAATALEWGLVSRVVPADQLLPAARALAERIA 206
PRK07799 PRK07799
crotonase/enoyl-CoA hydratase family protein;
99-285 7.66e-26

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181122 [Multi-domain]  Cd Length: 263  Bit Score: 102.87  E-value: 7.66e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279  99 IVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIrSEVPGIFCAGADLKERAKMSSSEV---GPF-VSKIRAV 174
Cdd:PRK07799  15 TLIVTMNRPEARNALSTEMLRIMVDAWDRVDNDPDIRSCIL-TGAGGAFCAGMDLKAATKKPPGDSfkdGSYdPSRIDAL 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 175 INDiANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVLD 254
Cdd:PRK07799  94 LKG-RRLTKPLIAAVEGPAIAGGTEILQGTDIRVAGESAKFGISEAKWSLFPMGGSAVRLVRQIPYTVACDLLLTGRHIT 172

                        170       180       190
                 ....*....|....*....|....*....|.
gi 530391279 255 GKEAKAVGLISHVLEQNQegdaAYRKALDLA 285
Cdd:PRK07799 173 AAEAKEIGLIGHVVPDGQ----ALDKALELA 199
PRK07509 PRK07509
crotonase/enoyl-CoA hydratase family protein;
104-289 1.25e-24

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181008 [Multi-domain]  Cd Length: 262  Bit Score: 99.57  E-value: 1.25e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 104 INRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEvPGIFCAGADLKERAKMSSSEVGpfvsKIRAVINDIAN--- 180
Cdd:PRK07509  18 LNRPDKMNALDFAMFEELIATIKRLKKDRGIRAVILSGE-GGAFCAGLDVKSVASSPGNAVK----LLFKRLPGNANlaq 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 181 --------LPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARV 252
Cdd:PRK07509  93 rvslgwrrLPVPVIAALEGVCFGGGLQIALGADIRIAAPDTKLSIMEAKWGLVPDMAGTVSLRGLVRKDVARELTYTARV 172

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 530391279 253 LDGKEAKAVGLISHVLEQnqegdaAYRKALDLAREFL 289
Cdd:PRK07509 173 FSAEEALELGLVTHVSDD------PLAAALALAREIA 203
PRK09674 PRK09674
enoyl-CoA hydratase-isomerase; Provisional
 94-267 7.70e-24

enoyl-CoA hydratase-isomerase; Provisional


Pssm-ID: 182026 [Multi-domain]  Cd Length: 255  Bit Score: 97.53  E-value: 7.70e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279  94 ADHYRIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEvPGIFCAGADLKERAKMSssevgpfvskIRA 173
Cdd:PRK09674   7 SRQQRVLLLTLNRPEARNALNNALLTQLVNELEAAATDTSIGVCVITGN-ARFFAAGADLNEMAEKD----------LAA 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 174 VIND--------IANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKE 245
Cdd:PRK09674  76 TLNDprpqlwqrLQAFNKPLIAAVNGYALGAGCELALLCDIVIAGENARFGLPEITLGIMPGAGGTQRLIRSVGKSLASQ 155

                        170       180
                 ....*....|....*....|..
gi 530391279 246 LIFSARVLDGKEAKAVGLISHV 267
Cdd:PRK09674 156 MVLTGESITAQQAQQAGLVSEV 177
PRK06190 PRK06190
enoyl-CoA hydratase; Provisional
 94-285 3.16e-23

enoyl-CoA hydratase; Provisional


Pssm-ID: 235733  Cd Length: 258  Bit Score: 95.81  E-value: 3.16e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279  94 ADHYRIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPgIFCAGADLKERAKMSSSEVGPFVSK--I 171
Cdd:PRK06190   9 ETHDRVRTLTLNRPEARNALSAALRRALFAALAEADADDDVDVVVLTGADP-AFCAGLDLKELGGDGSAYGAQDALPnpS 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 172 RAVindiANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSAR 251
Cdd:PRK06190  88 PAW----PAMRKPVIGAINGAAVTGGLELALACDILIASERARFADTHARVGILPGWGLSVRLPQKVGIGRARRMSLTGD 163

                        170       180       190
                 ....*....|....*....|....*....|....
gi 530391279 252 VLDGKEAKAVGLISHVLEQNQEGDAAYRKALDLA 285
Cdd:PRK06190 164 FLDAADALRAGLVTEVVPHDELLPRARRLAASIA 197
PRK08150 PRK08150
crotonase/enoyl-CoA hydratase family protein;
98-286 4.19e-23

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181254  Cd Length: 255  Bit Score: 95.47  E-value: 4.19e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279  98 RIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDkkVRTIIIRSEVPGiFCAGADLKERAKMSSSEVGPFVSKIRAVIND 177
Cdd:PRK08150  11 GVATIGLNRPAKRNALNDGLIAALRAAFARLPEG--VRAVVLHGEGDH-FCAGLDLSELRERDAGEGMHHSRRWHRVFDK 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 178 IANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVLDGKE 257
Cdd:PRK08150  88 IQYGRVPVIAALHGAVVGGGLELASAAHIRVADESTYFALPEGQRGIFVGGGGSVRVPRLIGVARMTDMMLTGRVYDAQE 167

                        170       180
                 ....*....|....*....|....*....
gi 530391279 258 AKAVGLISHVLEQNQegdaAYRKALDLAR 286
Cdd:PRK08150 168 GERLGLAQYLVPAGE----ALDKAMELAR 192
PRK05869 PRK05869
enoyl-CoA hydratase; Validated
 111-289 7.73e-21

enoyl-CoA hydratase; Validated


Pssm-ID: 235632 [Multi-domain]  Cd Length: 222  Bit Score: 88.36  E-value: 7.73e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 111 NSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEvPGIFCAGADLKERAKMSSSEVGPFVSKIRAVINDIANLPVPTIAAID 190
Cdd:PRK05869  29 NALTRQVYREIVAAANELGRRDDVAAVILYGG-HEIFSAGDDMPELRTLSAQEADTAARVRQQAVDAVAAIPKPTVAAIT 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 191 GLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVLDGKEAKAVGLISHVLEQ 270
Cdd:PRK05869 108 GYALGAGLTLALAADWRVSGDNVKFGATEILAGLAPSGDGMARLTRAAGPSRAKELVFSGRFFDAEEALALGLIDEMVAP 187

                        170
                 ....*....|....*....
gi 530391279 271 nqegDAAYRKALDLAREFL 289
Cdd:PRK05869 188 ----DDVYDAAAAWARRFL 202
PRK07468 PRK07468
crotonase/enoyl-CoA hydratase family protein;
88-277 1.22e-20

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 180987 [Multi-domain]  Cd Length: 262  Bit Score: 88.96  E-value: 1.22e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279  88 DSSSMAADHYRIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGiFCAGADLK-ERAKMSSSEVGP 166
Cdd:PRK07468   4 ETIRIAVDARGVATLTLNRPEKHNALSARMIAELTTAARRLAADAAVRVVVLTGAGKS-FCAGGDLGwMRAQMTADRATR 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 167 FVS--KIRAVINDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRaIGMSLAK 244
Cdd:PRK07468  83 IEEarRLAMMLKALNDLPKPLIGRIQGQAFGGGVGLISVCDVAIAVSGARFGLTETRLGLIPATISPYVVAR-MGEANAR 161

                        170       180       190
                 ....*....|....*....|....*....|...
gi 530391279 245 ELIFSARVLDGKEAKAVGLISHVLEQnQEGDAA 277
Cdd:PRK07468 162 RVFMSARLFDAEEAVRLGLLSRVVPA-ERLDAA 193
fadJ PRK11154
fatty acid oxidation complex subunit alpha FadJ;
128-282 1.75e-20

fatty acid oxidation complex subunit alpha FadJ;


Pssm-ID: 236864 [Multi-domain]  Cd Length: 708  Bit Score: 91.50  E-value: 1.75e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 128 LKSDKKVRTIIIRSEVPGIFCAGADLKERAKMSSSEVGPFVSKI-RAVINDIANLPVPTIAAIDGLALGGGLELALACDI 206
Cdd:PRK11154  46 LREDKELKGVVFISGKPDNFIAGADINMLAACKTAQEAEALARQgQQLFAEIEALPIPVVAAIHGACLGGGLELALACHY 125

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530391279 207 RVAASSAK--MGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVLDGKEAKAVGLISHVLEQNQEGDAAYRKAL 282
Cdd:PRK11154 126 RVCTDDPKtvLGLPEVQLGLLPGSGGTQRLPRLIGVSTALDMILTGKQLRAKQALKLGLVDDVVPHSILLEVAVELAK 203
PRK06143 PRK06143
enoyl-CoA hydratase; Provisional
 99-292 4.43e-19

enoyl-CoA hydratase; Provisional


Pssm-ID: 180423  Cd Length: 256  Bit Score: 84.32  E-value: 4.43e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279  99 IVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLKERAKMSSSEVGPFVSKIRAVINDI 178
Cdd:PRK06143  17 VATLTIRNAGSLNILGTPVILALTQALRWLAADPDVRVLVLRGAGEKAFIGGADIKEMATLDQASAEAFISRLRDLCDAV 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 179 ANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAiIPGGGGTQRLPRAIGMSLAKELIFSARVLDGKEA 258
Cdd:PRK06143  97 RHFPVPVIARIPGWCLGGGLELAAACDLRIAAHDAQFGMPEVRVG-IPSVIHAALLPRLIGWARTRWLLLTGETIDAAQA 175

                        170       180       190
                 ....*....|....*....|....*....|....
gi 530391279 259 KAVGLISHVLEqNQEGDAAYRKALDLAREFLPQV 292
Cdd:PRK06143 176 LAWGLVDRVVP-LAELDAAVERLAASLAGCGPQA 208
PRK06127 PRK06127
enoyl-CoA hydratase; Provisional
 98-267 5.46e-19

enoyl-CoA hydratase; Provisional


Pssm-ID: 235705  Cd Length: 269  Bit Score: 84.37  E-value: 5.46e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279  98 RIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLKERAKMSSSE--VGPFVSKIRAVI 175
Cdd:PRK06127  20 GLGRITFNNPARHNAMSLDMWEALPQALAAAEDDDAIRVVVLTGAGEKAFVSGADISQFEESRSDAeaVAAYEQAVEAAQ 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 176 NDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVLDG 255
Cdd:PRK06127 100 AALADYAKPTIACIRGYCIGGGMGIALACDIRIAAEDSRFGIPAARLGLGYGYDGVKNLVDLVGPSAAKDLFYTARRFDA 179

                        170
                 ....*....|..
gi 530391279 256 KEAKAVGLISHV 267
Cdd:PRK06127 180 AEALRIGLVHRV 191
PLN02888 PLN02888
enoyl-CoA hydratase
 99-285 8.98e-19

enoyl-CoA hydratase


Pssm-ID: 215480  Cd Length: 265  Bit Score: 83.65  E-value: 8.98e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279  99 IVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGiFCAGADLKerakmSSSEVGPFVSKIRAvINDI 178
Cdd:PLN02888  20 IATITINRPKALNALTRPMMVELAAAFKRLDEDDSVKVIILTGSGRA-FCSGVDLT-----AAEEVFKGDVKDVE-TDPV 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 179 ANLP---VPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVLDG 255
Cdd:PLN02888  93 AQMErcrKPIIGAINGFAITAGFEIALACDILVASRGAKFIDTHAKFGIFPSWGLSQKLSRIIGANRAREVSLTAMPLTA 172

                        170       180       190
                 ....*....|....*....|....*....|
gi 530391279 256 KEAKAVGLISHVLEQNQegdaAYRKALDLA 285
Cdd:PLN02888 173 ETAERWGLVNHVVEESE----LLKKAREVA 198
PRK08252 PRK08252
crotonase/enoyl-CoA hydratase family protein;
98-287 4.50e-18

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181325 [Multi-domain]  Cd Length: 254  Bit Score: 81.57  E-value: 4.50e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279  98 RIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIrSEVPGIFCAGADLKERAKmsssevGPFVSKIRAVIND 177
Cdd:PRK08252  12 RVLIITINRPEARNAVNAAVAQGLAAALDELDADPDLSVGIL-TGAGGTFCAGMDLKAFAR------GERPSIPGRGFGG 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 178 IANLPV--PTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVLDG 255
Cdd:PRK08252  85 LTERPPrkPLIAAVEGYALAGGFELALACDLIVAARDAKFGLPEVKRGLVAAGGGLLRLPRRIPYHIAMELALTGDMLTA 164

                        170       180       190
                 ....*....|....*....|....*....|..
gi 530391279 256 KEAKAVGLISHVLEQNQEGDAayrkALDLARE 287
Cdd:PRK08252 165 ERAHELGLVNRLTEPGQALDA----ALELAER 192
PRK05980 PRK05980
crotonase/enoyl-CoA hydratase family protein;
98-286 4.63e-18

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 180335 [Multi-domain]  Cd Length: 260  Bit Score: 81.73  E-value: 4.63e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279  98 RIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLKE----RAKMSSSEVGPFVSKIRA 173
Cdd:PRK05980  12 GIALLTLNRPEKLNALNYALIDRLLARLDAIEVDESVRAVILTGAGDRAFSAGADIHEfsasVAAGADVALRDFVRRGQA 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 174 VINDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVL 253
Cdd:PRK05980  92 MTARLEAFPKPVIAAVNGLAFGGGCEITEAVHLAIASERALFAKPEIRLGMPPTFGGTQRLPRLAGRKRALELLLTGDAF 171

                        170       180       190
                 ....*....|....*....|....*....|...
gi 530391279 254 DGKEAKAVGLISHVLEQNQEGDAAYRKALDLAR 286
Cdd:PRK05980 172 SAERALEIGLVNAVVPHEELLPAARALARRIIR 204
PRK08260 PRK08260
enoyl-CoA hydratase; Provisional
 99-288 8.34e-18

enoyl-CoA hydratase; Provisional


Pssm-ID: 236206 [Multi-domain]  Cd Length: 296  Bit Score: 81.59  E-value: 8.34e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279  99 IVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIirseVPG---IFCAGADL---------KERAKMSSS---- 162
Cdd:PRK08260  14 IATITLNRPDKLNAFTVTMARELIEAFDAADADDAVRAVI----VTGagrAFCAGADLsaggntfdlDAPRTPVEAdeed 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 163 EVGPFVSKIR----AVINDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAI 238
Cdd:PRK08260  90 RADPSDDGVRdgggRVTLRIFDSLKPVIAAVNGPAVGVGATMTLAMDIRLASTAARFGFVFGRRGIVPEAASSWFLPRLV 169

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 530391279 239 GMSLAKELIFSARVLDGKEAKAVGLISHVLEQNQEGDAAYrkalDLAREF 288
Cdd:PRK08260 170 GLQTALEWVYSGRVFDAQEALDGGLVRSVHPPDELLPAAR----ALAREI 215
PRK06494 PRK06494
enoyl-CoA hydratase; Provisional
 98-286 1.11e-17

enoyl-CoA hydratase; Provisional


Pssm-ID: 180591 [Multi-domain]  Cd Length: 259  Bit Score: 80.47  E-value: 1.11e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279  98 RIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLKERAKMSSSEVGP--FVSkiravI 175
Cdd:PRK06494  13 HVTIVTLNRPEVMNALHLDAHFELEEVFDDFAADPEQWVAIVTGAGDKAFSAGNDLKEQAAGGKRGWPEsgFGG-----L 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 176 NDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVLDG 255
Cdd:PRK06494  88 TSRFDLDKPIIAAVNGVAMGGGFELALACDLIVAAENATFALPEPRVGLAALAGGLHRLPRQIGLKRAMGMILTGRRVTA 167

                        170       180       190
                 ....*....|....*....|....*....|.
gi 530391279 256 KEAKAVGLISHVLEQNQEGDAAYRKALDLAR 286
Cdd:PRK06494 168 REGLELGFVNEVVPAGELLAAAERWADDILA 198
PRK06210 PRK06210
enoyl-CoA hydratase; Provisional
 94-290 1.34e-17

enoyl-CoA hydratase; Provisional


Pssm-ID: 180472  Cd Length: 272  Bit Score: 80.52  E-value: 1.34e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279  94 ADHYRIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGiFCAGADLKE------RAKMSSSEVGPF 167
Cdd:PRK06210  11 VADSGVAVITLNRPDRLNAWTPVMEAEVYAAMDRAEADPAVRVIVLTGAGRG-FCAGADMGElqtidpSDGRRDTDVRPF 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 168 VSKIRAVIND----IANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLA 243
Cdd:PRK06210  90 VGNRRPDYQTryhfLTALRKPVIAAINGACAGIGLTHALMCDVRFAADGAKFTTAFARRGLIAEHGISWILPRLVGHANA 169

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 530391279 244 KELIFSARVLDGKEAKAVGLISHVLEQNQEGDAAYRKALDLAREFLP 290
Cdd:PRK06210 170 LDLLLSARTFYAEEALRLGLVNRVVPPDELMERTLAYAEDLARNVSP 216
fa_ox_alpha_mit TIGR02441
fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of ...
 99-269 1.36e-17

fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of mitochondrial multifunctional fatty acid degradation enzyme complex. Subunit activities include: enoyl-CoA hydratase (EC 4.2.1.17) _ 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35). Some characterization in human (SP:P40939), pig (SP:Q29554), and rat (SP:Q64428). The beta subunit has activity: acetyl-CoA C-acyltransferase (EC 2.3.1.16).


Pssm-ID: 131494 [Multi-domain]  Cd Length: 737  Bit Score: 82.96  E-value: 1.36e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279   99 IVVLGINRAYGK-NSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLKE-RAKMSSSEVGPFVSKIRAVIN 176
Cdd:TIGR02441  23 VAVVKIDSPNSKvNTLSKELFAEFKEVMNELWTNEAIKSAVLISGKPGSFVAGADIQMiAACKTAQEVTQLSQEGQEMFE 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279  177 DIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAK--MGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVLD 254
Cdd:TIGR02441 103 RIEKSQKPIVAAISGSCLGGGLELALACHYRIATKDRKtlLGLPEVMLGLLPGAGGTQRLPKLTGVPAALDMMLTGKKIR 182

                         170
                  ....*....|....*
gi 530391279  255 GKEAKAVGLISHVLE 269
Cdd:TIGR02441 183 ADRAKKMGIVDQLVD 197
PLN02664 PLN02664
enoyl-CoA hydratase/delta3,5-delta2,4-dienoyl-CoA isomerase
 99-279 2.12e-17

enoyl-CoA hydratase/delta3,5-delta2,4-dienoyl-CoA isomerase


Pssm-ID: 178269 [Multi-domain]  Cd Length: 275  Bit Score: 80.33  E-value: 2.12e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279  99 IVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVrTIIIRSEVPGIFCAGADLKERAKMS----SSEVGPFVSKIR-- 172
Cdd:PLN02664  18 VFHLNLNRPSQRNALSLDFFTEFPKALSSLDQNPNV-SVIILSGAGDHFCSGIDLKTLNSISeqssSGDRGRSGERLRrk 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 173 -----AVINDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELI 247
Cdd:PLN02664  97 ikflqDAITAIEQCRKPVIAAIHGACIGGGVDIVTACDIRYCSEDAFFSVKEVDLAITADLGTLQRLPSIVGYGNAMELA 176

                        170       180       190
                 ....*....|....*....|....*....|..
gi 530391279 248 FSARVLDGKEAKAVGLISHVLEQNQEGDAAYR 279
Cdd:PLN02664 177 LTGRRFSGSEAKELGLVSRVFGSKEDLDEGVR 208
PRK05995 PRK05995
enoyl-CoA hydratase; Provisional
 104-269 2.63e-17

enoyl-CoA hydratase; Provisional


Pssm-ID: 235664 [Multi-domain]  Cd Length: 262  Bit Score: 79.58  E-value: 2.63e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 104 INRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGiFCAGADL---KERAKMSSSEVGPFVSKIRAVINDIAN 180
Cdd:PRK05995  19 LNRPDVRNAFNETVIAELTAAFRALDADDSVRAVVLAGAGKA-FCAGADLnwmKKMAGYSDDENRADARRLADMLRAIYR 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 181 LPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPggggTQRLP---RAIGMSLAKELIFSARVLDGKE 257
Cdd:PRK05995  98 CPKPVIARVHGDAYAGGMGLVAACDIAVAADHAVFCLSEVRLGLIP----ATISPyviRAMGERAARRYFLTAERFDAAE 173

                        170
                 ....*....|..
gi 530391279 258 AKAVGLISHVLE 269
Cdd:PRK05995 174 ALRLGLVHEVVP 185
PRK09076 PRK09076
enoyl-CoA hydratase; Provisional
 121-277 4.76e-17

enoyl-CoA hydratase; Provisional


Pssm-ID: 236373 [Multi-domain]  Cd Length: 258  Bit Score: 78.81  E-value: 4.76e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 121 LSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLKErakmsssevgpFVSKIRAVINDIA-----------NLPVPTIAAI 189
Cdd:PRK09076  34 LKQLVLELNADKDVYALVITGDGEKFFSAGADLNL-----------FADGDKAVAREMArrfgeafealsAFRGVSIAAI 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 190 DGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVLDGKEAKAVGLISHVLE 269
Cdd:PRK09076 103 NGYAMGGGLECALACDIRIAEEQAQMALPEASVGLLPCAGGTQNLPWLVGEGWAKRMILCGERVDAATALRIGLVEEVVE 182


                 ....*...
gi 530391279 270 QNQEGDAA 277
Cdd:PRK09076 183 KGEAREAA 190
PRK05870 PRK05870
enoyl-CoA hydratase; Provisional
 98-269 5.41e-17

enoyl-CoA hydratase; Provisional


Pssm-ID: 180298  Cd Length: 249  Bit Score: 78.61  E-value: 5.41e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279  98 RIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGiFCAGADLKERAKMSSSEVGPFVSKIRAVIND 177
Cdd:PRK05870  12 GVALITVNDPDRRNAVTAEMSAQLRAAVAAAEADPDVHALVVTGAGKA-FCAGADLTALGAAPGRPAEDGLRRIYDGFLA 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 178 IANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVLDGKE 257
Cdd:PRK05870  91 VASCPLPTIAAVNGAAVGAGLNLALAADVRIAGPKALFDARFQKLGLHPGGGATWMLQRAVGPQVARAALLFGMRFDAEA 170

                        170
                 ....*....|..
gi 530391279 258 AKAVGLISHVLE 269
Cdd:PRK05870 171 AVRHGLALMVAD 182
PRK11423 PRK11423
methylmalonyl-CoA decarboxylase; Provisional
 98-286 1.30e-16

methylmalonyl-CoA decarboxylase; Provisional


Pssm-ID: 236908 [Multi-domain]  Cd Length: 261  Bit Score: 77.76  E-value: 1.30e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279  98 RIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKkVRTIIIRSEVPG-IFCAGADLKE-----RAKMSSSEvgPFVSKI 171
Cdd:PRK11423  13 KIATITFNNPAKRNALSKVLIDDLMQALSDLNRPE-IRVVILRAPSGSkVWSAGHDIHElpsggRDPLSYDD--PLRQIL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 172 RAvindIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSAR 251
Cdd:PRK11423  90 RM----IQKFPKPVIAMVEGSVWGGAFELIMSCDLIIAASTSTFAMTPANLGVPYNLSGILNFTNDAGFHIVKEMFFTAS 165

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 530391279 252 VLDGKEAKAVGLISHVLEQNQEGDAAYrkalDLAR 286
Cdd:PRK11423 166 PITAQRALAVGILNHVVEVEELEDFTL----QMAH 196
PRK06144 PRK06144
enoyl-CoA hydratase; Provisional
 105-269 2.57e-15

enoyl-CoA hydratase; Provisional


Pssm-ID: 180424 [Multi-domain]  Cd Length: 262  Bit Score: 74.26  E-value: 2.57e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 105 NRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLKERAKMSSSEVG-PFVSKIRAVINDIANLPV 183
Cdd:PRK06144  24 NRPAARNAMTWAMYEGLAEICEAIAADPSIRAVVLRGAGDKAFVAGTDIAQFRAFSTAEDAvAYERRIDRVLGALEQLRV 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 184 PTIAAIDGLALGGGLELALACDIRVAASSAKMG----------LVETKLAiipggggtqRLPRAIGMSLAKELIFSARVL 253
Cdd:PRK06144 104 PTIAAIAGACVGGGAAIAAACDLRIATPSARFGfpiartlgncLSMSNLA---------RLVALLGAARVKDMLFTARLL 174

                        170
                 ....*....|....*.
gi 530391279 254 DGKEAKAVGLISHVLE 269
Cdd:PRK06144 175 EAEEALAAGLVNEVVE 190
PRK07511 PRK07511
enoyl-CoA hydratase; Provisional
 101-285 1.40e-14

enoyl-CoA hydratase; Provisional


Pssm-ID: 181009 [Multi-domain]  Cd Length: 260  Bit Score: 71.95  E-value: 1.40e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 101 VLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEvPGIFCAGADLK---ERAKMSSSEVGPFVSKIRAVIND 177
Cdd:PRK07511  15 VLTLSNPGARNALHPDMYAAGIEALNTAERDPSIRAVVLTGA-GGFFCAGGNLNrllENRAKPPSVQAASIDGLHDWIRA 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 178 IANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVLDGKE 257
Cdd:PRK07511  94 IRAFPKPVIAAVEGAAAGAGFSLALACDLLVAARDAKFVMAYVKVGLTPDGGGSWFLARALPRQLATELLLEGKPISAER 173

                        170       180
                 ....*....|....*....|....*...
gi 530391279 258 AKAVGLISHVLEQNQEGDAAYRKALDLA 285
Cdd:PRK07511 174 LHALGVVNRLAEPGQALAEALALADQLA 201
PRK06142 PRK06142
crotonase/enoyl-CoA hydratase family protein;
94-287 2.16e-14

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 235714  Cd Length: 272  Bit Score: 71.54  E-value: 2.16e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279  94 ADHyrIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGiFCAGADLKERA-----KMSSSEVGP-- 166
Cdd:PRK06142  13 ADH--VAQVTLNRPGKGNAMNPAFWSELPEIFRWLDADPEVRAVVLSGSGKH-FSYGIDLPAMAgvfgqLGKDGLARPrt 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 167 -FVSKIR---AVINDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSL 242
Cdd:PRK06142  90 dLRREILrlqAAINAVADCRKPVIAAVQGWCIGGGVDLISACDMRYASADAKFSVREVDLGMVADVGSLQRLPRIIGDGH 169

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 530391279 243 AKELIFSARVLDGKEAKAVGLISHVLEqnqEGDAAYRKALDLARE 287
Cdd:PRK06142 170 LRELALTGRDIDAAEAEKIGLVNRVYD---DADALLAAAHATARE 211
PRK08139 PRK08139
enoyl-CoA hydratase; Validated
 99-281 2.39e-14

enoyl-CoA hydratase; Validated


Pssm-ID: 181249  Cd Length: 266  Bit Score: 71.51  E-value: 2.39e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279  99 IVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPgIFCAGADLKE-RAKMSSSEVGPFVSKIRAVIND 177
Cdd:PRK08139  21 VATLTLNRPQAFNALSEAMLAALQAALDAIAADPSVRVVVLAAAGK-AFCAGHDLKEmRAARGLAYFRALFARCSRVMQA 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 178 IANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAII---PGGGgtqrLPRAIGMSLAKELIFSARVLD 254
Cdd:PRK08139 100 IVALPQPVIARVHGIATAAGCQLVASCDLAVAADTARFAVPGVNIGLFcstPMVA----LSRNVPRKQAMEMLLTGEFID 175

                        170       180
                 ....*....|....*....|....*..
gi 530391279 255 GKEAKAVGLISHVLEQNQEGDAAYRKA 281
Cdd:PRK08139 176 AATAREWGLVNRVVPADALDAAVARLA 202
PRK08140 PRK08140
enoyl-CoA hydratase; Provisional
 94-285 9.15e-14

enoyl-CoA hydratase; Provisional


Pssm-ID: 236163  Cd Length: 262  Bit Score: 69.56  E-value: 9.15e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279  94 ADHYRIVVLGINRAYGKNSLSKNLIKMLSKAVDALKsDKKVRTIIIRSEVPGiFCAGADLKERAKMSSSEV--------- 164
Cdd:PRK08140   9 AIEAGVATLTLNRPDKLNSFTREMHRELREALDQVE-DDGARALLLTGAGRG-FCAGQDLADRDVTPGGAMpdlgesiet 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 165 --GPFVSKIRAvindianLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSL 242
Cdd:PRK08140  87 fyNPLVRRLRA-------LPLPVIAAVNGVAAGAGANLALACDIVLAARSASFIQAFVKIGLVPDSGGTWFLPRLVGMAR 159

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 530391279 243 AKELIFSARVLDGKEAKAVGLISHVLEQNQEGDAAYRKALDLA 285
Cdd:PRK08140 160 ALGLALLGEKLSAEQAEQWGLIWRVVDDAALADEAQQLAAHLA 202
PRK08259 PRK08259
crotonase/enoyl-CoA hydratase family protein;
145-291 1.29e-13

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 236205  Cd Length: 254  Bit Score: 69.15  E-value: 1.29e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 145 GIFCAGADLKERAKMSSSEV-----GPF-VSKIRavindianLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLV 218
Cdd:PRK08259  58 GTFCAGADLKAVGTGRGNRLhpsgdGPMgPSRMR--------LSKPVIAAVSGYAVAGGLELALWCDLRVAEEDAVFGVF 129

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530391279 219 ETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVLDGKEAKAVGLISHVLEQNQEGDAAYRKALDLARefLPQ 291
Cdd:PRK08259 130 CRRWGVPLIDGGTVRLPRLIGHSRAMDLILTGRPVDADEALAIGLANRVVPKGQARAAAEELAAELAA--FPQ 200
PRK03580 PRK03580
crotonobetainyl-CoA hydratase;
127-285 2.28e-13

crotonobetainyl-CoA hydratase;


Pssm-ID: 179599 [Multi-domain]  Cd Length: 261  Bit Score: 68.57  E-value: 2.28e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 127 ALKSDKKVRTIIIRSEVPGIFCAGADLKERAKMSSSE----VGPFvskirAVINDIANLPVPTIAAIDGLALGGGLELAL 202
Cdd:PRK03580  40 NFRDDPELRVAIITGAGEKFFSAGWDLKAAAEGEAPDadfgPGGF-----AGLTEIFDLDKPVIAAVNGYAFGGGFELAL 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 203 ACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVLDGKEAKAVGLISHVLEQNQEGDAAYRKAL 282
Cdd:PRK03580 115 AADFIVCADNASFALPEAKLGIVPDSGGVLRLPKRLPPAIANEMVMTGRRMDAEEALRWGIVNRVVPQAELMDRARELAQ 194


                 ...
gi 530391279 283 DLA 285
Cdd:PRK03580 195 QLV 197
PRK05864 PRK05864
enoyl-CoA hydratase; Provisional
 95-297 3.83e-13

enoyl-CoA hydratase; Provisional


Pssm-ID: 168278 [Multi-domain]  Cd Length: 276  Bit Score: 67.94  E-value: 3.83e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279  95 DHYR--IVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGiFCAGADLKERAKMSSSE-VGPFVSKI 171
Cdd:PRK05864  14 DHPRpeIALITLNRPERMNSMAFDVMVPLKEALAEVSYDNSVRVVVLTGAGRG-FSSGADHKSAGVVPHVEgLTRPTYAL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 172 RA------VINDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKM-------GLVETKLaiipggGGTQRLPRAI 238
Cdd:PRK05864  93 RSmellddVILALRRLHQPVIAAVNGPAIGGGLCLALAADIRVASSSAYFraaginnGLTASEL------GLSYLLPRAI 166

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 530391279 239 GMSLAKELIFSARVLDGKEAKAVGLISHVLEQNQEGDAAYRKALDLAREFLPQVKQIRR 297
Cdd:PRK05864 167 GSSRAFEIMLTGRDVDAEEAERIGLVSRQVPDEQLLDTCYAIAARMAGFSRPGIELTKR 225
PRK08258 PRK08258
enoyl-CoA hydratase family protein;
98-286 5.07e-13

enoyl-CoA hydratase family protein;


Pssm-ID: 181329  Cd Length: 277  Bit Score: 67.68  E-value: 5.07e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279  98 RIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGiFCAGADLKE----RAKMSSSEVGPFVSKIRA 173
Cdd:PRK08258  26 GVATITLNRPERKNPLTFESYAELRDLFRELVYADDVKAVVLTGAGGN-FCSGGDVHEiigpLTKMDMPELLAFTRMTGD 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 174 VINDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETK--LAiipGG--GGTQRLPRAIGMSLAKELIFS 249
Cdd:PRK08258 105 LVKAMRACPQPIIAAVDGVCAGAGAILAMASDLRLGTPSAKTAFLFTRvgLA---GAdmGACALLPRIIGQGRASELLYT 181

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 530391279 250 ARVLDGKEAKAVGLISHVLEQNQEGDAAYRKALDLAR 286
Cdd:PRK08258 182 GRSMSAEEGERWGFFNRLVEPEELLAEAQALARRLAA 218
PRK07110 PRK07110
polyketide biosynthesis enoyl-CoA hydratase; Validated
 98-286 1.03e-12

polyketide biosynthesis enoyl-CoA hydratase; Validated


Pssm-ID: 235936  Cd Length: 249  Bit Score: 66.53  E-value: 1.03e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279  98 RIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSeVPGIFCAGADLK-----ERAKMSSSEVgPFVSKIr 172
Cdd:PRK07110  14 GIAQVTMQDRVNKNAFSDELCDQLHEAFDTIAQDPRYKVVILTG-YPNYFATGGTQEgllslQTGKGTFTEA-NLYSLA- 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 173 avindiANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARV 252
Cdd:PRK07110  91 ------LNCPIPVIAAMQGHAIGGGLVLGLYADIVVLSRESVYTANFMKYGFTPGMGATAILPEKLGLALGQEMLLTARY 164

                        170       180       190
                 ....*....|....*....|....*....|....
gi 530391279 253 LDGKEAKAVGLISHVLEQNQEGDAAYRKALDLAR 286
Cdd:PRK07110 165 YRGAELKKRGVPFPVLPRAEVLEKALELARSLAE 198
PRK06563 PRK06563
crotonase/enoyl-CoA hydratase family protein;
99-287 3.41e-12

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 180625 [Multi-domain]  Cd Length: 255  Bit Score: 64.98  E-value: 3.41e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279  99 IVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGiFCAGADLKERA--------KMSSSEVGPF--- 167
Cdd:PRK06563   9 VLLIGLDRPAKRNAFDSAMLDDLALALGEYEADDELRVAVLFAHGEH-FTAGLDLADVApklaaggfPFPEGGIDPWgtv 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 168 ---VSKiravindianlpvPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAK 244
Cdd:PRK06563  88 grrLSK-------------PLVVAVQGYCLTLGIELMLAADIVVAADNTRFAQLEVQRGILPFGGATLRFPQAAGWGNAM 154

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 530391279 245 ELIFSARVLDGKEAKAVGLISHVLEQNQEgdaaYRKALDLARE 287
Cdd:PRK06563 155 RYLLTGDEFDAQEALRLGLVQEVVPPGEQ----LERAIELAER 193
PRK07827 PRK07827
enoyl-CoA hydratase family protein;
98-291 4.87e-12

enoyl-CoA hydratase family protein;


Pssm-ID: 236109 [Multi-domain]  Cd Length: 260  Bit Score: 64.70  E-value: 4.87e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279  98 RIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIrSEVPGIFCAGADLKERAKMSSSEVGPFVSKIRAVIN- 176
Cdd:PRK07827  15 GVATLTLDSPHNRNALSARLVAQLHDGLRAAAADPAVRAVVL-THTGGTFCAGADLSEAGGGGGDPYDAAVARAREMTAl 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 177 --DIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARvLD 254
Cdd:PRK07827  94 lrAIVELPKPVIAAIDGHVRAGGFGLVGACDIVVAGPESTFALTEARIGVAPAIISLTLLPRLSPRAAARYYLTGEK-FG 172

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 530391279 255 GKEAKAVGLIShvlEQNQEGDAAYRKALDLAREFLPQ 291
Cdd:PRK07827 173 AAEAARIGLVT---AAADDVDAAVAALLADLRRGSPQ 206
PRK07659 PRK07659
enoyl-CoA hydratase; Provisional
 98-271 1.71e-11

enoyl-CoA hydratase; Provisional


Pssm-ID: 236073 [Multi-domain]  Cd Length: 260  Bit Score: 63.13  E-value: 1.71e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279  98 RIVVLGINRAYGKNSLSKNLIKMLSKAVDALK-SDKKVrtIIIRSEVPGiFCAGADLKERAKMSSSEVGPFVSK-IRAVI 175
Cdd:PRK07659  15 RVATIMLNRPEALNALDEPMLKELLQALKEVAeSSAHI--VVLRGNGRG-FSAGGDIKMMLSSNDESKFDGVMNtISEIV 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 176 NDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVLDG 255
Cdd:PRK07659  92 VTLYTMPKLTISAIHGPAAGLGLSIALTADYVIADISAKLAMNFIGIGLIPDGGGHFFLQKRVGENKAKQIIWEGKKLSA 171

                        170
                 ....*....|....*.
gi 530391279 256 KEAKAVGLISHVLEQN 271
Cdd:PRK07659 172 TEALDLGLIDEVIGGD 187
PRK05981 PRK05981
enoyl-CoA hydratase/isomerase;
111-297 1.73e-11

enoyl-CoA hydratase/isomerase;


Pssm-ID: 235661  Cd Length: 266  Bit Score: 63.21  E-value: 1.73e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 111 NSLSKNLIKMLSKAVDALKSDK-KVRTIIIRSEVPGiFCAGADLKER---AKMSSSEVG----------PFVSKIRavin 176
Cdd:PRK05981  26 NAVSIDMLGGLAEALDAIEDGKaEVRCLVLTGAGRG-FCTGANLQGRgsgGRESDSGGDagaaletayhPFLRRLR---- 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 177 diaNLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVLDGK 256
Cdd:PRK05981 101 ---NLPCPIVTAVNGPAAGVGMSFALMGDLILCARSAYFLQAFRRIGLVPDGGSTWLLPRLVGKARAMELSLLGEKLPAE 177

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 530391279 257 EAKAVGLISHVLEQNQEGDAAYRKALDLAREFLPQVKQIRR 297
Cdd:PRK05981 178 TALQWGLVNRVVDDAELMAEAMKLAHELANGPTVALGLIRK 218
PRK06495 PRK06495
enoyl-CoA hydratase/isomerase family protein;
111-287 1.17e-10

enoyl-CoA hydratase/isomerase family protein;


Pssm-ID: 168580 [Multi-domain]  Cd Length: 257  Bit Score: 60.48  E-value: 1.17e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 111 NSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEvPGIFCAGADLKERAKMSSSEvGPFVS---KIRAVINDIANLPVPTIA 187
Cdd:PRK06495  25 NALSRELRDELIAVFDEISERPDVRVVVLTGA-GKVFCAGADLKGRPDVIKGP-GDLRAhnrRTRECFHAIRECAKPVIA 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 188 AIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIpggGGTQRLPRAIGMSLAKELIFSARVLDGKEAKAVGLISHV 267
Cdd:PRK06495 103 AVNGPALGAGLGLVASCDIIVASENAVFGLPEIDVGLA---GGGKHAMRLFGHSLTRRMMLTGYRVPAAELYRRGVIEAC 179

                        170       180
                 ....*....|....*....|
gi 530391279 268 LeqnqEGDAAYRKALDLARE 287
Cdd:PRK06495 180 L----PPEELMPEAMEIARE 195
PLN02921 PLN02921
naphthoate synthase
 104-267 2.01e-10

naphthoate synthase


Pssm-ID: 178509 [Multi-domain]  Cd Length: 327  Bit Score: 60.57  E-value: 2.01e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 104 INRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLKERAKmsSSEVGPFVSKIRAVIN---DIAN 180
Cdd:PLN02921  82 INRPERRNAFRPRTVKELQRAFNDARDDSSVGVIILTGKGTKAFCSGGDQAVRGK--DGYVGPDDAGRLNVLDlqiQIRR 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 181 LPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVLDGKEAKA 260
Cdd:PLN02921 160 LPKPVIAMVAGYAVGGGHILHMVCDLTIAADNAVFGQTGPKVGSFDAGYGSSIMARLVGQKKAREMWFLARFYTASEALK 239


                 ....*..
gi 530391279 261 VGLISHV 267
Cdd:PLN02921 240 MGLVNTV 246
PRK07854 PRK07854
enoyl-CoA hydratase; Provisional
 98-263 1.52e-09

enoyl-CoA hydratase; Provisional


Pssm-ID: 236115 [Multi-domain]  Cd Length: 243  Bit Score: 57.34  E-value: 1.52e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279  98 RIVVLGINRAYGKNSLSKNLIKMLSKAVDALkSDKKVRTIIIRSEVPgIFCAGADLKERAKMSSsevgpFVSKIRAVIND 177
Cdd:PRK07854   9 QVLTIELQRPERRNALNAELCEELREAVRKA-VDESARAIVLTGQGT-VFCAGADLSGDVYADD-----FPDALIEMLHA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 178 IANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVLDGKE 257
Cdd:PRK07854  82 IDAAPVPVIAAINGPAIGAGLQLAMACDLRVVAPEAYFQFPVAKYGIALDNWTIRRLSSLVGGGRARAMLLGAEKLTAEQ 161


                 ....*.
gi 530391279 258 AKAVGL 263
Cdd:PRK07854 162 ALATGM 167
PLN03214 PLN03214
probable enoyl-CoA hydratase/isomerase; Provisional
 111-281 1.71e-09

probable enoyl-CoA hydratase/isomerase; Provisional


Pssm-ID: 215635  Cd Length: 278  Bit Score: 57.58  E-value: 1.71e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 111 NSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEV-PGIFCAGADLKE--RAKMSSSEVGPFVSKIRAVINDIANLPVPTIA 187
Cdd:PLN03214  33 NSMTLAMWRSLDDALTALENDPTVRGVVFASGLrRDVFTAGNDIAElyAPKTSAARYAEFWLTQTTFLVRLLRSRLATVC 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 188 AIDGLALGGGLELALACDIRVAASSAKMGLVETKLAI-IPGGGGTQRLPRAIGMSLAKELIFSARVLDGKEAKAVGLISH 266
Cdd:PLN03214 113 AIRGACPAGGCAVSLCCDYRLQTTEGTMGLNEVALGIpVPKFWARLFMGRVIDRKVAESLLLRGRLVRPAEAKQLGLIDE 192

                        170
                 ....*....|....*
gi 530391279 267 VLEQNQEGDAAYRKA 281
Cdd:PLN03214 193 VVPAAALMEAAASAM 207
PRK08788 PRK08788
enoyl-CoA hydratase; Validated
 118-279 3.04e-09

enoyl-CoA hydratase; Validated


Pssm-ID: 236338  Cd Length: 287  Bit Score: 56.84  E-value: 3.04e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 118 IKMLSKAVDALKSDKK--VRTIIIRSEVPGIFCAGADL---------KERAKMsssevgpfVSKIRAVINDI------AN 180
Cdd:PRK08788  48 IMNLQRAIRQRLDDSGlpVDFWVLASDVPGVFNLGGDLalfaeliraGDRDAL--------LAYARACVDGVhafhrgFG 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 181 LPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVLDGKEAKA 260
Cdd:PRK08788 120 AGAISIALVQGDALGGGFEAALSHHTIIAERGAKMGFPEILFNLFPGMGAYSFLARRVGPKLAEELILSGKLYTAEELHD 199

                        170
                 ....*....|....*....
gi 530391279 261 VGLISHVLEQNQeGDAAYR 279
Cdd:PRK08788 200 MGLVDVLVEDGQ-GEAAVR 217
PRK05674 PRK05674
gamma-carboxygeranoyl-CoA hydratase; Validated
 102-287 1.11e-08

gamma-carboxygeranoyl-CoA hydratase; Validated


Pssm-ID: 168168  Cd Length: 265  Bit Score: 54.81  E-value: 1.11e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 102 LGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGiFCAGADL---KERAKMSSSEVGPFVSKIRAVINDI 178
Cdd:PRK05674  19 LWLSRADKNNAFNAQMIRELILALDQVQSDASLRFLLLRGRGRH-FSAGADLawmQQSADLDYNTNLDDARELAELMYNL 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 179 ANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTqRLPRAIGMSLAKELIFSARVLDGKEA 258
Cdd:PRK05674  98 YRLKIPTLAVVQGAAFGGALGLISCCDMAIGADDAQFCLSEVRIGLAPAVISP-FVVKAIGERAARRYALTAERFDGRRA 176

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 530391279 259 KAVGLISHV-----LEQNQE---------GDAAYRKALDLARE 287
Cdd:PRK05674 177 RELGLLAESypaaeLEAQVEawianlllnSPQALRASKDLLRE 219
PRK07938 PRK07938
enoyl-CoA hydratase family protein;
121-285 2.25e-08

enoyl-CoA hydratase family protein;


Pssm-ID: 181174  Cd Length: 249  Bit Score: 53.82  E-value: 2.25e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 121 LSKAVDALKSDKKVRTIIIRSEVPGiFCAGADLKERAKMSSSEV------GPFVSkIRAVINDianlPVPTIAAIDGLAL 194
Cdd:PRK07938  33 LADAITAAGADPDTRVVVLRAEGRG-FNAGVDIKELQATPGFTAlidanrGCFAA-FRAVYEC----AVPVIAAVHGFCL 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 195 GGGLELALACDIRVAASSAKMGLVETKLAIIpgGGGTQrLPRAIGMSLAKELIFSARVLDGKEAKAVGLISHVLEQNQEG 274
Cdd:PRK07938 107 GGGIGLVGNADVIVASDDATFGLPEVDRGAL--GAATH-LQRLVPQHLMRALFFTAATITAAELHHFGSVEEVVPRDQLD 183

                        170
                 ....*....|.
gi 530391279 275 DAAYRKALDLA 285
Cdd:PRK07938 184 EAALEVARKIA 194
PRK07260 PRK07260
enoyl-CoA hydratase; Provisional
 99-269 2.54e-08

enoyl-CoA hydratase; Provisional


Pssm-ID: 180910 [Multi-domain]  Cd Length: 255  Bit Score: 53.59  E-value: 2.54e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279  99 IVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPgIFCAGADLKERAKMSSSEVGPFVSKIRAVINDI 178
Cdd:PRK07260  12 LATLTLNRPEVSNGFNIPMCQEILEALRLAEEDPSVRFLLINANGK-VFSVGGDLVEMKRAVDEDDVQSLVKIAELVNEI 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 179 A----NLPVPTIAAIDGLALGGGLELALACDIRVAASSAKM--GLVETKLAiiPGGGGTQRLPRAIGMSLAKELIFSARV 252
Cdd:PRK07260  91 SfaikQLPKPVIMCVDGAVAGAAANMAVAADFCIASTKTKFiqAFVGVGLA--PDAGGLFLLTRAIGLNRATHLAMTGEA 168

                        170
                 ....*....|....*..
gi 530391279 253 LDGKEAKAVGLISHVLE 269
Cdd:PRK07260 169 LTAEKALEYGFVYRVAE 185
PRK07327 PRK07327
enoyl-CoA hydratase/isomerase family protein;
98-286 6.10e-08

enoyl-CoA hydratase/isomerase family protein;


Pssm-ID: 235991  Cd Length: 268  Bit Score: 52.72  E-value: 6.10e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279  98 RIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGiFCAGADLKERAKMSSS-EVGPFVSK-IRAVI 175
Cdd:PRK07327  21 GVLEIVLNGPGALNAADARMHRELADIWRDVDRDPDVRVVLIRGEGKA-FSAGGDLALVEEMADDfEVRARVWReARDLV 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 176 NDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVLDG 255
Cdd:PRK07327 100 YNVINCDKPIVSAIHGPAVGAGLVAALLADISIAAKDARIIDGHTRLGVAAGDHAAIVWPLLCGMAKAKYYLLLCEPVSG 179

                        170       180       190
                 ....*....|....*....|....*....|.
gi 530391279 256 KEAKAVGLISHVLEQNQEGDAAYRKALDLAR 286
Cdd:PRK07327 180 EEAERIGLVSLAVDDDELLPKALEVAERLAA 210
PRK06023 PRK06023
crotonase/enoyl-CoA hydratase family protein;
96-297 5.65e-07

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 168351  Cd Length: 251  Bit Score: 49.79  E-value: 5.65e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279  96 HYRIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSeVPGIFCAGADLKE--RAKMSSSEVGPfvsKIRA 173
Cdd:PRK06023  13 HPGVQVIRFNRPEKKNAITRAMYATMAKALKAADADDAIRAHVFLG-TEGCFSAGNDMQDflAAAMGGTSFGS---EILD 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 174 VINDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVL 253
Cdd:PRK06023  89 FLIALAEAEKPIVSGVDGLAIGIGTTIHLHCDLTFASPRSLFRTPFVDLALVPEAGSSLLAPRLMGHQRAFALLALGEGF 168

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 530391279 254 DGKEAKAVGLISHVLEQNQEGDAAYRKALDLAREfLPQVKQIRR 297
Cdd:PRK06023 169 SAEAAQEAGLIWKIVDEEAVEAETLKAAEELAAK-PPQALQIAR 211
PRK09120 PRK09120
p-hydroxycinnamoyl CoA hydratase/lyase; Validated
 105-264 5.75e-07

p-hydroxycinnamoyl CoA hydratase/lyase; Validated


Pssm-ID: 236383  Cd Length: 275  Bit Score: 50.01  E-value: 5.75e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 105 NRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGiFCAGADLKE--RAKMSSSEVGpfVSKIRAVIND----I 178
Cdd:PRK09120  24 NRPEKRNAMSPTLNREMIDVLDALEFDDDAGVLVLTGAGDA-WSAGMDLKEyfRETDAQPEIL--QERIRREAYGwwrrL 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 179 ANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVLDGKEA 258
Cdd:PRK09120 101 RWYQKPTIAMVNGWCFGGGFSPLVACDLAIAADEAQFGLSEINWGIPPGGGVSKAMADTVGHRDALYYIMTGETFTGRKA 180


                 ....*.
gi 530391279 259 KAVGLI 264
Cdd:PRK09120 181 AEMGLV 186
ECH_2 pfam16113
Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: ...
 111-269 8.18e-07

Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase. This family differs from pfam00378 in the structure of it's C-terminus.


Pssm-ID: 465024 [Multi-domain]  Cd Length: 331  Bit Score: 49.78  E-value: 8.18e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279  111 NSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLKERAKM----SSSEVGPFVSKIRAVINDIANLPVPTI 186
Cdd:pfam16113  13 NALNLEMVRALLAALKAWEDDPAVKLVVLKGAGERAFCAGGDVRALYEAakagGGEAGRDFFREEYRLNYLIATYPKPYV 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279  187 AAIDGLalggglelalaCDIRVAASSAKMGLVETKLAIIPGGGGT---QRLPRAIGMSLAkeliFSARVLDGKEAKAVGL 263
Cdd:pfam16113  93 ALMDGIvmgggvglsvhGSFRVVTERTRFAMPETAIGLFPDVGGSyflSRLPGELGLYLA----LTGARLNGADALAAGL 168


                  ....*.
gi 530391279  264 ISHVLE 269
Cdd:pfam16113 169 ATHYVP 174
PRK08290 PRK08290
enoyl-CoA hydratase; Provisional
 98-267 1.67e-06

enoyl-CoA hydratase; Provisional


Pssm-ID: 236220 [Multi-domain]  Cd Length: 288  Bit Score: 48.42  E-value: 1.67e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279  98 RIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGiFCAGADLKERAKMSSSEVGPF---VSKIRAV 174
Cdd:PRK08290  13 RIARITLNRPEARNAQNRQMLYELDAAFRRAEADDAVRVIVLAGAGKH-FSAGHDLGSGTPGRDRDPGPDqhpTLWWDGA 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 175 IND-------------------IANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIipggGGTQRL- 234
Cdd:PRK08290  92 TKPgveqryarewevylgmcrrWRDLPKPTIAQVQGACIAGGLMLAWVCDLIVASDDAFFSDPVVRMGI----PGVEYFa 167

                        170       180       190
                 ....*....|....*....|....*....|....
gi 530391279 235 -PRAIGMSLAKELIFSARVLDGKEAKAVGLISHV 267
Cdd:PRK08290 168 hPWELGPRKAKELLFTGDRLTADEAHRLGMVNRV 201
PRK06072 PRK06072
enoyl-CoA hydratase; Provisional
 95-247 9.16e-06

enoyl-CoA hydratase; Provisional


Pssm-ID: 168377 [Multi-domain]  Cd Length: 248  Bit Score: 45.93  E-value: 9.16e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279  95 DHYRIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGiFCAGADLkerakmsSSEVGPFVSKIRA- 173
Cdd:PRK06072   6 SREGYAIVTMSRPDKLNALNLEMRNEFISKLKQINADPKIRVVIVTGEGRA-FCVGADL-------SEFAPDFAIDLREt 77

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 530391279 174 ---VINDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELI 247
Cdd:PRK06072  78 fypIIREIRFSDKIYISAINGVTAGACIGIALSTDFKFASRDVKFVTAFQRLGLASDTGVAYFLLKLTGQRFYEILV 154
PRK07396 PRK07396
dihydroxynaphthoic acid synthetase; Validated
 104-267 1.83e-05

dihydroxynaphthoic acid synthetase; Validated


Pssm-ID: 180958 [Multi-domain]  Cd Length: 273  Bit Score: 45.27  E-value: 1.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 104 INRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLKERAK---MSSSEVGPFvsKIRAVINDIAN 180
Cdd:PRK07396  28 INRPEVRNAFRPKTVKEMIDAFADARDDDNIGVIILTGAGDKAFCSGGDQKVRGYggyVDDDGVPRL--NVLDLQRLIRT 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 181 LPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVLDGKEAKA 260
Cdd:PRK07396 106 CPKPVIAMVAGYAIGGGHVLHLVCDLTIAADNAIFGQTGPKVGSFDGGYGASYLARIVGQKKAREIWFLCRQYDAQEALD 185


                 ....*..
gi 530391279 261 VGLISHV 267
Cdd:PRK07396 186 MGLVNTV 192
PRK08272 PRK08272
crotonase/enoyl-CoA hydratase family protein;
98-263 2.68e-05

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 236213  Cd Length: 302  Bit Score: 45.03  E-value: 2.68e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279  98 RIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGiFCAGADLKERAK-MSSSEVGPFVSKIRAVIN 176
Cdd:PRK08272  19 RIARITLNRPEKGNAITADTPLELRAAVERADLDPGVHVILVSGAGKG-FCAGYDLSAYAEgSSSGGGGGAYPGKRQAVN 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 177 DIANLP------------------------VPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGG--- 229
Cdd:PRK08272  98 HLPDDPwdpmidyqmmsrfvrgfmslwhahKPTVAKVHGYCVAGGTDIALHCDQVIAADDAKIGYPPTRVWGVPATGmwa 177

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 530391279 230 ---GTQRlpraigmslAKELIFSARVLDGKEAKAVGL 263
Cdd:PRK08272 178 yrlGPQR---------AKRLLFTGDCITGAQAAEWGL 205
PRK05617 PRK05617
3-hydroxyisobutyryl-CoA hydrolase; Provisional
 98-282 5.65e-05

3-hydroxyisobutyryl-CoA hydrolase; Provisional


Pssm-ID: 235533 [Multi-domain]  Cd Length: 342  Bit Score: 44.04  E-value: 5.65e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279  98 RIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLKE-----RAKMSSSEVGPFVSKIR 172
Cdd:PRK05617  12 GVGVITLNRPKALNALSLEMIRAIDAALDAWEDDDAVAAVVIEGAGERGFCAGGDIRAlyeaaRAGDPLAADRFFREEYR 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 173 avIN-DIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRA---IGMSLAkeliF 248
Cdd:PRK05617  92 --LNaLIARYPKPYIALMDGIVMGGGVGISAHGSHRIVTERTKMAMPETGIGFFPDVGGTYFLSRApgaLGTYLA----L 165

                        170       180       190
                 ....*....|....*....|....*....|....
gi 530391279 249 SARVLDGKEAKAVGLISHVLEQNQEgdAAYRKAL 282
Cdd:PRK05617 166 TGARISAADALYAGLADHFVPSADL--PALLDAL 197
PLN02267 PLN02267
enoyl-CoA hydratase/isomerase family protein
 109-189 1.61e-03

enoyl-CoA hydratase/isomerase family protein


Pssm-ID: 215151  Cd Length: 239  Bit Score: 39.31  E-value: 1.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 109 GKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLK--ERAKMSSSEVGPFVSKIRAVINDIANLPVPTI 186
Cdd:PLN02267  19 GEHRLNPTLIDSIRSALRQVKSQATPGSVLITTAEGKFFSNGFDLAwaQAAGSAPSRLHLMVAKLRPLVADLISLPMPTI 98


                 ...
gi 530391279 187 AAI 189
Cdd:PLN02267  99 AAV 101
PLN02988 PLN02988
3-hydroxyisobutyryl-CoA hydrolase
 84-266 9.91e-03

3-hydroxyisobutyryl-CoA hydrolase


Pssm-ID: 178568 [Multi-domain]  Cd Length: 381  Bit Score: 37.39  E-value: 9.91e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279  84 EENRDSSSMAADHYRIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGiFCAGADLKerAKMSSSE 163
Cdd:PLN02988   4 EMASQSQVLVEEKSSVRILTLNRPKQLNALSFHMISRLLQLFLAFEEDPSVKLVILKGHGRA-FCAGGDVA--AVVRDIE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391279 164 VGP------FVSKIRAVINDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRA 237
Cdd:PLN02988  81 QGNwrlganFFSDEYMLNYVMATYSKAQVSILNGIVMGGGAGVSVHGRFRIATENTVFAMPETALGLFPDVGASYFLSRL 160

                        170       180
                 ....*....|....*....|....*....
gi 530391279 238 IGMsLAKELIFSARVLDGKEAKAVGLISH 266
Cdd:PLN02988 161 PGF-FGEYVGLTGARLDGAEMLACGLATH 188
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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