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Conserved domains on  [gi|530395134|ref|XP_005252879|]
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anoctamin-5 isoform X1 [Homo sapiens]

Protein Classification

anoctamin( domain architecture ID 11241320)

anoctamin (anion channel with 8 transmembrane domains) is a calcium-activated protein and may mediate the calcium-dependent exposure of phospholipids to the extracellular surface, a process called phospholipid scrambling

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Anoctamin pfam04547
Calcium-activated chloride channel; The family carries eight putative transmembrane domains, ...
266-842 1.24e-126

Calcium-activated chloride channel; The family carries eight putative transmembrane domains, and, although it has no similarity to other known channel proteins, it is clearly a calcium-activated ionic channel. It is expressed in various secretory epithelia, the retina and sensory neurons, and mediates receptor-activated chloride currents in diverse physiological processes.


:

Pssm-ID: 461349  Cd Length: 377  Bit Score: 386.17  E-value: 1.24e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530395134  266 IKNYYGEKIGIYFVFLGFYTEMLFFAAVVGLACFIYGllsmehntssteicdpeiggqmimcplcdqvcdywrlnstcla 345
Cdd:pfam04547   1 IRDYFGEKIAFYFAFLGFYTKWLLPPAIVGLLVFLYG------------------------------------------- 37
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530395134  346 skFSHLFDnESTVFFAIFMGIWVTLFLEFWKQRQARLEYEWDLVDFEEEQQQlqlRPEFEAMCKHRklNAVTKEMEPYMP 425
Cdd:pfam04547  38 --LATLFD-PYTVFFAIFMSLWATLFLEFWKRREAELAYRWGTTGFEEEEEP---RPEFKGEKERI--NPVTGEKEPYYP 109
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530395134  426 LY-TRIPWYFLSGATVTLWMSLVVtsmVAVIVYrlsvfatfasfmesdaslkqvksfltpqittsltgsclnfiviliLN 504
Cdd:pfam04547 110 PWkRRLRRYLLSIPLVLLLIALLV---LGVIIY---------------------------------------------LN 141
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530395134  505 FFYEKISAWITKMEIPRTYQEYESSLTLKMFLfqfvnfysscfyvaffkgkfvgypgkytylfnewrseecdpggclIEL 584
Cdd:pfam04547 142 FVYTKLAKKLTDWENHRTQSEYENSLILKVFL---------------------------------------------DRL 176
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530395134  585 TTQLTIIMTGKQIFGNIKEAIYPLALNWWRRRKARTNSEK--------------LYSRWEQDHDLESFGPlglFYEYLET 650
Cdd:pfam04547 177 RIQLAIIMVTKQIINNITEVVLPYLKRKRRKKRKKKKKKEepsvsikdepeeseFLERVEKEYELEPYDG---LDDYLEM 253
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530395134  651 VTQFGFVTLFVASFPLAPLLALINNIVEIRVDAWKLTTQYRRTVASKAHSIGVWQDILYGMAVLSVATNAFIV-AFTSDi 729
Cdd:pfam04547 254 VIQFGYVTLFSAAFPLAPLFALLNNIIEIRSDAFKLCTELRRPVPERADSIGPWLNILEFLSWLAVITNAALIyAFTSD- 332
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530395134  730 iprlvyyyaystnatqpmtgyvnnslsvfliadfpnhtapsekrdfitcryrdyryppddenkyfhnmQFWHVLAAKMTF 809
Cdd:pfam04547 333 --------------------------------------------------------------------QYWSLLALLLAF 344
                         570       580       590
                  ....*....|....*....|....*....|...
gi 530395134  810 IIVMEHVVFLVKFLLAWMIPDVPKDVVERIKRE 842
Cdd:pfam04547 345 VIVFEHVVLLLKFLIAWLIPDVPEWVRKERKRE 377
Anoct_dimer pfam16178
dimerization domain of Ca+-activated chloride-channel, anoctamin; This family appears to be ...
46-263 1.33e-99

dimerization domain of Ca+-activated chloride-channel, anoctamin; This family appears to be the cytoplasmic domain of the calcium-activated chloride-channel, anoctamin, protein. It is responsible for creating the homodimeric architecture of the chloride-channel proteins.


:

Pssm-ID: 465044  Cd Length: 224  Bit Score: 309.88  E-value: 1.33e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530395134   46 FFRDGIRQIDFVLSYVDD---VKKDAELKAERRKEFETNLRKTGLELEIEDKrdSEDGRTYFVKIHAPWEVLVTYAEVLG 122
Cdd:pfam16178   1 YFRDGKRKIDYVLVYEEEkeeSKREEEKKREKRETFEENLIEEGLELEREKE--ESDQGTHFVKIHAPWEVLCRYAEILK 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530395134  123 IKMPIK------ESDIPRPKHTPISYVL-GPVRLPLSVKYPHPEYFTAQFSRHRQELFLIEDQATFFPSSSRNRIVYYIL 195
Cdd:pfam16178  79 IKMPIKkkiekeESSIPGRLDNLSRKLLsKPFIPDVETFPKEPDYFTAPFSRDKMYLFLIEDKDTFFTNATRSRIVYEIL 158
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530395134  196 SRCPFGiEDGKKRFGIERLLNSNTYSSAYPLHDGQYWKPSEpPNPTNERYTLHQNWARFSYFYKEQPL 263
Cdd:pfam16178 159 SRTRYG-GRKKKEVGIKRLLNEGVYLAAYPLHDGPYKLPKD-PSELNERQLLYEEWARWGKWYKYQPL 224
COG5594 super family cl35025
Uncharacterized integral membrane protein [Function unknown];
436-557 1.14e-03

Uncharacterized integral membrane protein [Function unknown];


The actual alignment was detected with superfamily member COG5594:

Pssm-ID: 227881 [Multi-domain]  Cd Length: 827  Bit Score: 42.79  E-value: 1.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530395134 436 SGATVTLWMSLVVTSMVAVIVyrlsVFATFASFMESDASLKQVkSFLTPQITTSLTGsCLNFIVILILNFFYEKISAWIT 515
Cdd:COG5594  415 SANILFILLIILWAFPVAFVG----TISNLNTLSSLWPFLKFI-LKDPPFLAGILTG-LLPTVALSLLMSIVPYFIRWLS 488
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 530395134 516 KMEIPRTYQEYESSLTLKMFLFQFVNFysscFYVAFFKGKFV 557
Cdd:COG5594  489 YMQGLVSYSEEEIYVQNKYFAFLFVNL----FLVVTLASSFS 526
 
Name Accession Description Interval E-value
Anoctamin pfam04547
Calcium-activated chloride channel; The family carries eight putative transmembrane domains, ...
266-842 1.24e-126

Calcium-activated chloride channel; The family carries eight putative transmembrane domains, and, although it has no similarity to other known channel proteins, it is clearly a calcium-activated ionic channel. It is expressed in various secretory epithelia, the retina and sensory neurons, and mediates receptor-activated chloride currents in diverse physiological processes.


Pssm-ID: 461349  Cd Length: 377  Bit Score: 386.17  E-value: 1.24e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530395134  266 IKNYYGEKIGIYFVFLGFYTEMLFFAAVVGLACFIYGllsmehntssteicdpeiggqmimcplcdqvcdywrlnstcla 345
Cdd:pfam04547   1 IRDYFGEKIAFYFAFLGFYTKWLLPPAIVGLLVFLYG------------------------------------------- 37
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530395134  346 skFSHLFDnESTVFFAIFMGIWVTLFLEFWKQRQARLEYEWDLVDFEEEQQQlqlRPEFEAMCKHRklNAVTKEMEPYMP 425
Cdd:pfam04547  38 --LATLFD-PYTVFFAIFMSLWATLFLEFWKRREAELAYRWGTTGFEEEEEP---RPEFKGEKERI--NPVTGEKEPYYP 109
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530395134  426 LY-TRIPWYFLSGATVTLWMSLVVtsmVAVIVYrlsvfatfasfmesdaslkqvksfltpqittsltgsclnfiviliLN 504
Cdd:pfam04547 110 PWkRRLRRYLLSIPLVLLLIALLV---LGVIIY---------------------------------------------LN 141
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530395134  505 FFYEKISAWITKMEIPRTYQEYESSLTLKMFLfqfvnfysscfyvaffkgkfvgypgkytylfnewrseecdpggclIEL 584
Cdd:pfam04547 142 FVYTKLAKKLTDWENHRTQSEYENSLILKVFL---------------------------------------------DRL 176
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530395134  585 TTQLTIIMTGKQIFGNIKEAIYPLALNWWRRRKARTNSEK--------------LYSRWEQDHDLESFGPlglFYEYLET 650
Cdd:pfam04547 177 RIQLAIIMVTKQIINNITEVVLPYLKRKRRKKRKKKKKKEepsvsikdepeeseFLERVEKEYELEPYDG---LDDYLEM 253
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530395134  651 VTQFGFVTLFVASFPLAPLLALINNIVEIRVDAWKLTTQYRRTVASKAHSIGVWQDILYGMAVLSVATNAFIV-AFTSDi 729
Cdd:pfam04547 254 VIQFGYVTLFSAAFPLAPLFALLNNIIEIRSDAFKLCTELRRPVPERADSIGPWLNILEFLSWLAVITNAALIyAFTSD- 332
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530395134  730 iprlvyyyaystnatqpmtgyvnnslsvfliadfpnhtapsekrdfitcryrdyryppddenkyfhnmQFWHVLAAKMTF 809
Cdd:pfam04547 333 --------------------------------------------------------------------QYWSLLALLLAF 344
                         570       580       590
                  ....*....|....*....|....*....|...
gi 530395134  810 IIVMEHVVFLVKFLLAWMIPDVPKDVVERIKRE 842
Cdd:pfam04547 345 VIVFEHVVLLLKFLIAWLIPDVPEWVRKERKRE 377
Anoct_dimer pfam16178
dimerization domain of Ca+-activated chloride-channel, anoctamin; This family appears to be ...
46-263 1.33e-99

dimerization domain of Ca+-activated chloride-channel, anoctamin; This family appears to be the cytoplasmic domain of the calcium-activated chloride-channel, anoctamin, protein. It is responsible for creating the homodimeric architecture of the chloride-channel proteins.


Pssm-ID: 465044  Cd Length: 224  Bit Score: 309.88  E-value: 1.33e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530395134   46 FFRDGIRQIDFVLSYVDD---VKKDAELKAERRKEFETNLRKTGLELEIEDKrdSEDGRTYFVKIHAPWEVLVTYAEVLG 122
Cdd:pfam16178   1 YFRDGKRKIDYVLVYEEEkeeSKREEEKKREKRETFEENLIEEGLELEREKE--ESDQGTHFVKIHAPWEVLCRYAEILK 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530395134  123 IKMPIK------ESDIPRPKHTPISYVL-GPVRLPLSVKYPHPEYFTAQFSRHRQELFLIEDQATFFPSSSRNRIVYYIL 195
Cdd:pfam16178  79 IKMPIKkkiekeESSIPGRLDNLSRKLLsKPFIPDVETFPKEPDYFTAPFSRDKMYLFLIEDKDTFFTNATRSRIVYEIL 158
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530395134  196 SRCPFGiEDGKKRFGIERLLNSNTYSSAYPLHDGQYWKPSEpPNPTNERYTLHQNWARFSYFYKEQPL 263
Cdd:pfam16178 159 SRTRYG-GRKKKEVGIKRLLNEGVYLAAYPLHDGPYKLPKD-PSELNERQLLYEEWARWGKWYKYQPL 224
COG5594 COG5594
Uncharacterized integral membrane protein [Function unknown];
436-557 1.14e-03

Uncharacterized integral membrane protein [Function unknown];


Pssm-ID: 227881 [Multi-domain]  Cd Length: 827  Bit Score: 42.79  E-value: 1.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530395134 436 SGATVTLWMSLVVTSMVAVIVyrlsVFATFASFMESDASLKQVkSFLTPQITTSLTGsCLNFIVILILNFFYEKISAWIT 515
Cdd:COG5594  415 SANILFILLIILWAFPVAFVG----TISNLNTLSSLWPFLKFI-LKDPPFLAGILTG-LLPTVALSLLMSIVPYFIRWLS 488
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 530395134 516 KMEIPRTYQEYESSLTLKMFLFQFVNFysscFYVAFFKGKFV 557
Cdd:COG5594  489 YMQGLVSYSEEEIYVQNKYFAFLFVNL----FLVVTLASSFS 526
 
Name Accession Description Interval E-value
Anoctamin pfam04547
Calcium-activated chloride channel; The family carries eight putative transmembrane domains, ...
266-842 1.24e-126

Calcium-activated chloride channel; The family carries eight putative transmembrane domains, and, although it has no similarity to other known channel proteins, it is clearly a calcium-activated ionic channel. It is expressed in various secretory epithelia, the retina and sensory neurons, and mediates receptor-activated chloride currents in diverse physiological processes.


Pssm-ID: 461349  Cd Length: 377  Bit Score: 386.17  E-value: 1.24e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530395134  266 IKNYYGEKIGIYFVFLGFYTEMLFFAAVVGLACFIYGllsmehntssteicdpeiggqmimcplcdqvcdywrlnstcla 345
Cdd:pfam04547   1 IRDYFGEKIAFYFAFLGFYTKWLLPPAIVGLLVFLYG------------------------------------------- 37
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530395134  346 skFSHLFDnESTVFFAIFMGIWVTLFLEFWKQRQARLEYEWDLVDFEEEQQQlqlRPEFEAMCKHRklNAVTKEMEPYMP 425
Cdd:pfam04547  38 --LATLFD-PYTVFFAIFMSLWATLFLEFWKRREAELAYRWGTTGFEEEEEP---RPEFKGEKERI--NPVTGEKEPYYP 109
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530395134  426 LY-TRIPWYFLSGATVTLWMSLVVtsmVAVIVYrlsvfatfasfmesdaslkqvksfltpqittsltgsclnfiviliLN 504
Cdd:pfam04547 110 PWkRRLRRYLLSIPLVLLLIALLV---LGVIIY---------------------------------------------LN 141
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530395134  505 FFYEKISAWITKMEIPRTYQEYESSLTLKMFLfqfvnfysscfyvaffkgkfvgypgkytylfnewrseecdpggclIEL 584
Cdd:pfam04547 142 FVYTKLAKKLTDWENHRTQSEYENSLILKVFL---------------------------------------------DRL 176
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530395134  585 TTQLTIIMTGKQIFGNIKEAIYPLALNWWRRRKARTNSEK--------------LYSRWEQDHDLESFGPlglFYEYLET 650
Cdd:pfam04547 177 RIQLAIIMVTKQIINNITEVVLPYLKRKRRKKRKKKKKKEepsvsikdepeeseFLERVEKEYELEPYDG---LDDYLEM 253
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530395134  651 VTQFGFVTLFVASFPLAPLLALINNIVEIRVDAWKLTTQYRRTVASKAHSIGVWQDILYGMAVLSVATNAFIV-AFTSDi 729
Cdd:pfam04547 254 VIQFGYVTLFSAAFPLAPLFALLNNIIEIRSDAFKLCTELRRPVPERADSIGPWLNILEFLSWLAVITNAALIyAFTSD- 332
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530395134  730 iprlvyyyaystnatqpmtgyvnnslsvfliadfpnhtapsekrdfitcryrdyryppddenkyfhnmQFWHVLAAKMTF 809
Cdd:pfam04547 333 --------------------------------------------------------------------QYWSLLALLLAF 344
                         570       580       590
                  ....*....|....*....|....*....|...
gi 530395134  810 IIVMEHVVFLVKFLLAWMIPDVPKDVVERIKRE 842
Cdd:pfam04547 345 VIVFEHVVLLLKFLIAWLIPDVPEWVRKERKRE 377
Anoct_dimer pfam16178
dimerization domain of Ca+-activated chloride-channel, anoctamin; This family appears to be ...
46-263 1.33e-99

dimerization domain of Ca+-activated chloride-channel, anoctamin; This family appears to be the cytoplasmic domain of the calcium-activated chloride-channel, anoctamin, protein. It is responsible for creating the homodimeric architecture of the chloride-channel proteins.


Pssm-ID: 465044  Cd Length: 224  Bit Score: 309.88  E-value: 1.33e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530395134   46 FFRDGIRQIDFVLSYVDD---VKKDAELKAERRKEFETNLRKTGLELEIEDKrdSEDGRTYFVKIHAPWEVLVTYAEVLG 122
Cdd:pfam16178   1 YFRDGKRKIDYVLVYEEEkeeSKREEEKKREKRETFEENLIEEGLELEREKE--ESDQGTHFVKIHAPWEVLCRYAEILK 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530395134  123 IKMPIK------ESDIPRPKHTPISYVL-GPVRLPLSVKYPHPEYFTAQFSRHRQELFLIEDQATFFPSSSRNRIVYYIL 195
Cdd:pfam16178  79 IKMPIKkkiekeESSIPGRLDNLSRKLLsKPFIPDVETFPKEPDYFTAPFSRDKMYLFLIEDKDTFFTNATRSRIVYEIL 158
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530395134  196 SRCPFGiEDGKKRFGIERLLNSNTYSSAYPLHDGQYWKPSEpPNPTNERYTLHQNWARFSYFYKEQPL 263
Cdd:pfam16178 159 SRTRYG-GRKKKEVGIKRLLNEGVYLAAYPLHDGPYKLPKD-PSELNERQLLYEEWARWGKWYKYQPL 224
COG5594 COG5594
Uncharacterized integral membrane protein [Function unknown];
436-557 1.14e-03

Uncharacterized integral membrane protein [Function unknown];


Pssm-ID: 227881 [Multi-domain]  Cd Length: 827  Bit Score: 42.79  E-value: 1.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530395134 436 SGATVTLWMSLVVTSMVAVIVyrlsVFATFASFMESDASLKQVkSFLTPQITTSLTGsCLNFIVILILNFFYEKISAWIT 515
Cdd:COG5594  415 SANILFILLIILWAFPVAFVG----TISNLNTLSSLWPFLKFI-LKDPPFLAGILTG-LLPTVALSLLMSIVPYFIRWLS 488
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 530395134 516 KMEIPRTYQEYESSLTLKMFLFQFVNFysscFYVAFFKGKFV 557
Cdd:COG5594  489 YMQGLVSYSEEEIYVQNKYFAFLFVNL----FLVVTLASSFS 526
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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