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Conserved domains on  [gi|578820665|ref|XP_005253091|]
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signal peptide, CUB and EGF-like domain-containing protein 2 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
797-908 1.81e-23

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 96.33  E-value: 1.81e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578820665 797 CGGEL-GDFTGYIESPNYPGNYPANTECTWTINPPPKRRILIVVPEIFLPIEDDCG-DYLVMRKTSSSNSVTTYETCqTY 874
Cdd:cd00041    1 CGGTLtASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSyDYLEIYDGPSTSSPLLGRFC-GS 79
                         90       100       110
                 ....*....|....*....|....*....|....
gi 578820665 875 ERPIAFTSRSKKLWIQFKSNEGNSARGFQVPYVT 908
Cdd:cd00041   80 TLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
Ephrin_rec_like pfam07699
Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region ...
745-792 2.79e-13

Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region rich in cysteines. It is found in various ephrin type A and B receptors, which have tyrosine kinase activity.


:

Pssm-ID: 429604 [Multi-domain]  Cd Length: 48  Bit Score: 65.06  E-value: 2.79e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 578820665  745 GHFYNTTTHRCIRCPVGTYQPEFGKNNCVSCPGNTTTDFDGSTNITQC 792
Cdd:pfam07699   1 GTYSNTGLEPCIPCPRGTYQPEEGQLSCLACPLGTTTDSPGATSISDC 48
Ephrin_rec_like pfam07699
Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region ...
689-736 6.73e-12

Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region rich in cysteines. It is found in various ephrin type A and B receptors, which have tyrosine kinase activity.


:

Pssm-ID: 429604 [Multi-domain]  Cd Length: 48  Bit Score: 60.83  E-value: 6.73e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 578820665  689 GEYSADGFAPCQLCALGTFQPEAGRTSCFPCGGGLATKHQGATSFQDC 736
Cdd:pfam07699   1 GTYSNTGLEPCIPCPRGTYQPEEGQLSCLACPLGTTTDSPGATSISDC 48
Ephrin_rec_like pfam07699
Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region ...
632-682 7.72e-10

Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region rich in cysteines. It is found in various ephrin type A and B receptors, which have tyrosine kinase activity.


:

Pssm-ID: 429604 [Multi-domain]  Cd Length: 48  Bit Score: 55.05  E-value: 7.72e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 578820665  632 GTYYDGARERCILCPNGTFQNEEGQMTCEPCPRPGNSgalKTPEAWNMSEC 682
Cdd:pfam07699   1 GTYSNTGLEPCIPCPRGTYQPEEGQLSCLACPLGTTT---DSPGATSISDC 48
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
49-84 3.23e-09

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 52.99  E-value: 3.23e-09
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 578820665   49 CAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQC 84
Cdd:pfam12947   1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
286-321 6.35e-09

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 52.24  E-value: 6.35e-09
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 578820665  286 CAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTC 321
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
132-167 2.16e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 50.70  E-value: 2.16e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 578820665  132 CLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTC 167
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
vWFA super family cl00057
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation ...
312-361 1.48e-07

Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains.


The actual alignment was detected with superfamily member cd01475:

Pssm-ID: 469594 [Multi-domain]  Cd Length: 224  Bit Score: 53.16  E-value: 1.48e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 578820665 312 FTLQLDGKTCKDIDECQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKS 361
Cdd:cd01475  175 LTKKFQGKICVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
217-252 1.14e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 45.70  E-value: 1.14e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 578820665  217 CNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSC 252
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
vWFA super family cl00057
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation ...
359-395 1.29e-06

Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains.


The actual alignment was detected with superfamily member cd01475:

Pssm-ID: 469594 [Multi-domain]  Cd Length: 224  Bit Score: 50.46  E-value: 1.29e-06
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 578820665 359 EKSCQDVDECS-LDRTCDHSCINHPGTFACACNRGYTL 395
Cdd:cd01475  181 GKICVVPDLCAtLSHVCQQVCISTPGSYLCACTEGYAL 218
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
95-126 7.95e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 43.39  E-value: 7.95e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 578820665   95 NGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNC 126
Cdd:pfam14670   5 NGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
177-213 6.74e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 37.99  E-value: 6.74e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 578820665  177 CMNKDHGCSHICKEAPrGSVACECRPGFELAKNQRDC 213
Cdd:pfam14670   1 CSVNNGGCSHLCLNTP-GGYTCSCPEGYELQDDGRTC 36
 
Name Accession Description Interval E-value
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
797-908 1.81e-23

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 96.33  E-value: 1.81e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578820665 797 CGGEL-GDFTGYIESPNYPGNYPANTECTWTINPPPKRRILIVVPEIFLPIEDDCG-DYLVMRKTSSSNSVTTYETCqTY 874
Cdd:cd00041    1 CGGTLtASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSyDYLEIYDGPSTSSPLLGRFC-GS 79
                         90       100       110
                 ....*....|....*....|....*....|....
gi 578820665 875 ERPIAFTSRSKKLWIQFKSNEGNSARGFQVPYVT 908
Cdd:cd00041   80 TLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB pfam00431
CUB domain;
797-906 2.27e-20

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 87.35  E-value: 2.27e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578820665  797 CGGELGDFTGYIESPNYPGNYPANTECTWTINPPPKRRILIVVPEIFLPIEDDCG-DYLVMRKTSSSNSVTTYETCqTYE 875
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGyDYVEIRDGPSASSPLLGRFC-GSG 79
                          90       100       110
                  ....*....|....*....|....*....|.
gi 578820665  876 RPIAFTSRSKKLWIQFKSNEGNSARGFQVPY 906
Cdd:pfam00431  80 IPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
806-906 2.18e-18

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 81.28  E-value: 2.18e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578820665   806 GYIESPNYPGNYPANTECTWTINPPPKRRILIVVPEIFLPIEDDCG-DYLVMRKTSSSNSVTTYETCQTYERPIAFTSRS 884
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEyDYVEIYDGPSASSPLLGRFCGSEAPPPVISSSS 80
                           90       100
                   ....*....|....*....|..
gi 578820665   885 KKLWIQFKSNEGNSARGFQVPY 906
Cdd:smart00042  81 NSLTLTFVSDSSVQKRGFSARY 102
Ephrin_rec_like pfam07699
Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region ...
745-792 2.79e-13

Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region rich in cysteines. It is found in various ephrin type A and B receptors, which have tyrosine kinase activity.


Pssm-ID: 429604 [Multi-domain]  Cd Length: 48  Bit Score: 65.06  E-value: 2.79e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 578820665  745 GHFYNTTTHRCIRCPVGTYQPEFGKNNCVSCPGNTTTDFDGSTNITQC 792
Cdd:pfam07699   1 GTYSNTGLEPCIPCPRGTYQPEEGQLSCLACPLGTTTDSPGATSISDC 48
Ephrin_rec_like pfam07699
Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region ...
689-736 6.73e-12

Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region rich in cysteines. It is found in various ephrin type A and B receptors, which have tyrosine kinase activity.


Pssm-ID: 429604 [Multi-domain]  Cd Length: 48  Bit Score: 60.83  E-value: 6.73e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 578820665  689 GEYSADGFAPCQLCALGTFQPEAGRTSCFPCGGGLATKHQGATSFQDC 736
Cdd:pfam07699   1 GTYSNTGLEPCIPCPRGTYQPEEGQLSCLACPLGTTTDSPGATSISDC 48
Ephrin_rec_like pfam07699
Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region ...
632-682 7.72e-10

Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region rich in cysteines. It is found in various ephrin type A and B receptors, which have tyrosine kinase activity.


Pssm-ID: 429604 [Multi-domain]  Cd Length: 48  Bit Score: 55.05  E-value: 7.72e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 578820665  632 GTYYDGARERCILCPNGTFQNEEGQMTCEPCPRPGNSgalKTPEAWNMSEC 682
Cdd:pfam07699   1 GTYSNTGLEPCIPCPRGTYQPEEGQLSCLACPLGTTT---DSPGATSISDC 48
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
49-84 3.23e-09

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 52.99  E-value: 3.23e-09
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 578820665   49 CAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQC 84
Cdd:pfam12947   1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
286-321 6.35e-09

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 52.24  E-value: 6.35e-09
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 578820665  286 CAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTC 321
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
132-167 2.16e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 50.70  E-value: 2.16e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 578820665  132 CLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTC 167
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
312-361 1.48e-07

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 53.16  E-value: 1.48e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 578820665 312 FTLQLDGKTCKDIDECQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKS 361
Cdd:cd01475  175 LTKKFQGKICVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
217-252 1.14e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 45.70  E-value: 1.14e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 578820665  217 CNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSC 252
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
359-395 1.29e-06

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 50.46  E-value: 1.29e-06
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 578820665 359 EKSCQDVDECS-LDRTCDHSCINHPGTFACACNRGYTL 395
Cdd:cd01475  181 GKICVVPDLCAtLSHVCQQVCISTPGSYLCACTEGYAL 218
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
327-362 1.75e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 45.31  E-value: 1.75e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 578820665  327 CQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSC 362
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
45-85 6.38e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 6.38e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 578820665  45 DVDECAQGlDDCHADALCQNTPTSYKCSCKPGYqgEGRQCE 85
Cdd:cd00054    1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGY--TGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
45-85 6.47e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 6.47e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 578820665    45 DVDECAQGlDDCHADALCQNTPTSYKCSCKPGYQgEGRQCE 85
Cdd:smart00179   1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGYT-DGRNCE 39
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
95-126 7.95e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 43.39  E-value: 7.95e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 578820665   95 NGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNC 126
Cdd:pfam14670   5 NGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
126-166 1.26e-04

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 44.30  E-value: 1.26e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 578820665 126 CLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHT 166
Cdd:cd01475  184 CVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
177-213 6.74e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 37.99  E-value: 6.74e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 578820665  177 CMNKDHGCSHICKEAPrGSVACECRPGFELAKNQRDC 213
Cdd:pfam14670   1 CSVNNGGCSHLCLNTP-GGYTCSCPEGYELQDDGRTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
128-158 1.26e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 1.26e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 578820665   128 DVDECLENNGgCQH--TCVNVMGSYECCCKEGF 158
Cdd:smart00179   1 DIDECASGNP-CQNggTCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
86-126 1.36e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 1.36e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 578820665    86 DIDECgnELNGGCVHD--CLNIPGNYRCTCFDGFmlaHDGHNC 126
Cdd:smart00179   1 DIDEC--ASGNPCQNGgtCVNTVGSYRCECPPGY---TDGRNC 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
364-394 1.59e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 1.59e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 578820665   364 DVDECSLDRTCDH--SCINHPGTFACACNRGYT 394
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
323-363 4.22e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.69  E-value: 4.22e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 578820665   323 DIDECQTRNGgCDH--FCKNIVGSFDCGCKKGFkllTDEKSCQ 363
Cdd:smart00179   1 DIDECASGNP-CQNggTCVNTVGSYRCECPPGY---TDGRNCE 39
 
Name Accession Description Interval E-value
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
797-908 1.81e-23

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 96.33  E-value: 1.81e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578820665 797 CGGEL-GDFTGYIESPNYPGNYPANTECTWTINPPPKRRILIVVPEIFLPIEDDCG-DYLVMRKTSSSNSVTTYETCqTY 874
Cdd:cd00041    1 CGGTLtASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSyDYLEIYDGPSTSSPLLGRFC-GS 79
                         90       100       110
                 ....*....|....*....|....*....|....
gi 578820665 875 ERPIAFTSRSKKLWIQFKSNEGNSARGFQVPYVT 908
Cdd:cd00041   80 TLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB pfam00431
CUB domain;
797-906 2.27e-20

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 87.35  E-value: 2.27e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578820665  797 CGGELGDFTGYIESPNYPGNYPANTECTWTINPPPKRRILIVVPEIFLPIEDDCG-DYLVMRKTSSSNSVTTYETCqTYE 875
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGyDYVEIRDGPSASSPLLGRFC-GSG 79
                          90       100       110
                  ....*....|....*....|....*....|.
gi 578820665  876 RPIAFTSRSKKLWIQFKSNEGNSARGFQVPY 906
Cdd:pfam00431  80 IPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
806-906 2.18e-18

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 81.28  E-value: 2.18e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578820665   806 GYIESPNYPGNYPANTECTWTINPPPKRRILIVVPEIFLPIEDDCG-DYLVMRKTSSSNSVTTYETCQTYERPIAFTSRS 884
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEyDYVEIYDGPSASSPLLGRFCGSEAPPPVISSSS 80
                           90       100
                   ....*....|....*....|..
gi 578820665   885 KKLWIQFKSNEGNSARGFQVPY 906
Cdd:smart00042  81 NSLTLTFVSDSSVQKRGFSARY 102
Ephrin_rec_like pfam07699
Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region ...
745-792 2.79e-13

Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region rich in cysteines. It is found in various ephrin type A and B receptors, which have tyrosine kinase activity.


Pssm-ID: 429604 [Multi-domain]  Cd Length: 48  Bit Score: 65.06  E-value: 2.79e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 578820665  745 GHFYNTTTHRCIRCPVGTYQPEFGKNNCVSCPGNTTTDFDGSTNITQC 792
Cdd:pfam07699   1 GTYSNTGLEPCIPCPRGTYQPEEGQLSCLACPLGTTTDSPGATSISDC 48
Ephrin_rec_like pfam07699
Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region ...
689-736 6.73e-12

Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region rich in cysteines. It is found in various ephrin type A and B receptors, which have tyrosine kinase activity.


Pssm-ID: 429604 [Multi-domain]  Cd Length: 48  Bit Score: 60.83  E-value: 6.73e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 578820665  689 GEYSADGFAPCQLCALGTFQPEAGRTSCFPCGGGLATKHQGATSFQDC 736
Cdd:pfam07699   1 GTYSNTGLEPCIPCPRGTYQPEEGQLSCLACPLGTTTDSPGATSISDC 48
Ephrin_rec_like pfam07699
Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region ...
632-682 7.72e-10

Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region rich in cysteines. It is found in various ephrin type A and B receptors, which have tyrosine kinase activity.


Pssm-ID: 429604 [Multi-domain]  Cd Length: 48  Bit Score: 55.05  E-value: 7.72e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 578820665  632 GTYYDGARERCILCPNGTFQNEEGQMTCEPCPRPGNSgalKTPEAWNMSEC 682
Cdd:pfam07699   1 GTYSNTGLEPCIPCPRGTYQPEEGQLSCLACPLGTTT---DSPGATSISDC 48
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
49-84 3.23e-09

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 52.99  E-value: 3.23e-09
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 578820665   49 CAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQC 84
Cdd:pfam12947   1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
286-321 6.35e-09

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 52.24  E-value: 6.35e-09
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 578820665  286 CAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTC 321
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
132-167 2.16e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 50.70  E-value: 2.16e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 578820665  132 CLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTC 167
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
312-361 1.48e-07

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 53.16  E-value: 1.48e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 578820665 312 FTLQLDGKTCKDIDECQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKS 361
Cdd:cd01475  175 LTKKFQGKICVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224
EGF_CA pfam07645
Calcium-binding EGF domain;
45-76 1.09e-06

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 45.69  E-value: 1.09e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 578820665   45 DVDECAQGLDDCHADALCQNTPTSYKCSCKPG 76
Cdd:pfam07645   1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
217-252 1.14e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 45.70  E-value: 1.14e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 578820665  217 CNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSC 252
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
359-395 1.29e-06

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 50.46  E-value: 1.29e-06
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 578820665 359 EKSCQDVDECS-LDRTCDHSCINHPGTFACACNRGYTL 395
Cdd:cd01475  181 GKICVVPDLCAtLSHVCQQVCISTPGSYLCACTEGYAL 218
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
327-362 1.75e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 45.31  E-value: 1.75e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 578820665  327 CQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSC 362
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
45-85 6.38e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 6.38e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 578820665  45 DVDECAQGlDDCHADALCQNTPTSYKCSCKPGYqgEGRQCE 85
Cdd:cd00054    1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGY--TGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
45-85 6.47e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 6.47e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 578820665    45 DVDECAQGlDDCHADALCQNTPTSYKCSCKPGYQgEGRQCE 85
Cdd:smart00179   1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGYT-DGRNCE 39
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
95-126 7.95e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 43.39  E-value: 7.95e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 578820665   95 NGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNC 126
Cdd:pfam14670   5 NGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
126-166 1.26e-04

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 44.30  E-value: 1.26e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 578820665 126 CLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHT 166
Cdd:cd01475  184 CVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
305-326 1.78e-04

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


Pssm-ID: 463661  Cd Length: 22  Bit Score: 39.31  E-value: 1.78e-04
                          10        20
                  ....*....|....*....|..
gi 578820665  305 HCSCPVGFTLQLDGKTCKDIDE 326
Cdd:pfam12662   1 TCSCPPGYQLDPDGRTCVDIDE 22
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
177-213 6.74e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 37.99  E-value: 6.74e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 578820665  177 CMNKDHGCSHICKEAPrGSVACECRPGFELAKNQRDC 213
Cdd:pfam14670   1 CSVNNGGCSHLCLNTP-GGYTCSCPEGYELQDDGRTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
128-158 1.26e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 1.26e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 578820665   128 DVDECLENNGgCQH--TCVNVMGSYECCCKEGF 158
Cdd:smart00179   1 DIDECASGNP-CQNggTCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
86-126 1.36e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 1.36e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 578820665    86 DIDECgnELNGGCVHD--CLNIPGNYRCTCFDGFmlaHDGHNC 126
Cdd:smart00179   1 DIDEC--ASGNPCQNGgtCVNTVGSYRCECPPGY---TDGRNC 38
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
110-131 1.49e-03

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


Pssm-ID: 463661  Cd Length: 22  Bit Score: 36.62  E-value: 1.49e-03
                          10        20
                  ....*....|....*....|..
gi 578820665  110 RCTCFDGFMLAHDGHNCLDVDE 131
Cdd:pfam12662   1 TCSCPPGYQLDPDGRTCVDIDE 22
EGF_CA smart00179
Calcium-binding EGF-like domain;
364-394 1.59e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 1.59e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 578820665   364 DVDECSLDRTCDH--SCINHPGTFACACNRGYT 394
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
364-395 3.38e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 3.38e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 578820665 364 DVDECSLDRTCDHS--CINHPGTFACACNRGYTL 395
Cdd:cd00054    1 DIDECASGNPCQNGgtCVNTVGSYRCSCPPGYTG 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
323-363 4.22e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.69  E-value: 4.22e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 578820665   323 DIDECQTRNGgCDH--FCKNIVGSFDCGCKKGFkllTDEKSCQ 363
Cdd:smart00179   1 DIDECASGNP-CQNggTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
48-85 4.35e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 35.92  E-value: 4.35e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 578820665  48 ECAQGlDDCHADALCQNTPTSYKCSCKPGYQGEGRqCE 85
Cdd:cd00053    1 ECAAS-NPCSNGGTCVNTPGSYRCVCPPGYTGDRS-CE 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
128-158 8.12e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 34.92  E-value: 8.12e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 578820665 128 DVDECLENNG-GCQHTCVNVMGSYECCCKEGF 158
Cdd:cd00054    1 DIDECASGNPcQNGGTCVNTVGSYRCSCPPGY 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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