NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|530395775|ref|XP_005253179|]
View 

zinc finger protein 143 isoform X2 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
265-438 1.08e-14

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 77.04  E-value: 1.08e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530395775 265 AHHLKVHERSHTGdRPYQCEHAGCGKAFATGYGLKSHVRT--HTGE--KPYRCSEDNCTKSFKTSGDLQKHIRTHTGERP 340
Cdd:COG5048  273 SSPNESDSSSEKG-FSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSISP 351

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530395775 341 FKCPFEGCGRSFTTSNIRKVHVRTH-----TGERPYYCTEPGCGRAFASATNYKNHVRIHTGEKPYVCTVPGCDKRFTEY 415
Cdd:COG5048  352 AKEKLLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRH 431

                        170       180
                 ....*....|....*....|...
gi 530395775 416 SSLYKHHVVHTHSKPYNCNHCGK 438
Cdd:COG5048  432 YNLIPHKKIHTNHAPLLCSILKS 454
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
265-438 1.08e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 77.04  E-value: 1.08e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530395775 265 AHHLKVHERSHTGdRPYQCEHAGCGKAFATGYGLKSHVRT--HTGE--KPYRCSEDNCTKSFKTSGDLQKHIRTHTGERP 340
Cdd:COG5048  273 SSPNESDSSSEKG-FSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSISP 351

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530395775 341 FKCPFEGCGRSFTTSNIRKVHVRTH-----TGERPYYCTEPGCGRAFASATNYKNHVRIHTGEKPYVCTVPGCDKRFTEY 415
Cdd:COG5048  352 AKEKLLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRH 431

                        170       180
                 ....*....|....*....|...
gi 530395775 416 SSLYKHHVVHTHSKPYNCNHCGK 438
Cdd:COG5048  432 YNLIPHKKIHTNHAPLLCSILKS 454
zf-H2C2_2 pfam13465
Zinc-finger double domain;
327-354 1.06e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.36  E-value: 1.06e-05
                          10        20
                  ....*....|....*....|....*...
gi 530395775  327 DLQKHIRTHTGERPFKCPFegCGRSFTT 354
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
265-438 1.08e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 77.04  E-value: 1.08e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530395775 265 AHHLKVHERSHTGdRPYQCEHAGCGKAFATGYGLKSHVRT--HTGE--KPYRCSEDNCTKSFKTSGDLQKHIRTHTGERP 340
Cdd:COG5048  273 SSPNESDSSSEKG-FSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSISP 351

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530395775 341 FKCPFEGCGRSFTTSNIRKVHVRTH-----TGERPYYCTEPGCGRAFASATNYKNHVRIHTGEKPYVCTVPGCDKRFTEY 415
Cdd:COG5048  352 AKEKLLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRH 431

                        170       180
                 ....*....|....*....|...
gi 530395775 416 SSLYKHHVVHTHSKPYNCNHCGK 438
Cdd:COG5048  432 YNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
369-444 4.93e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.94  E-value: 4.93e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530395775 369 RPYYCtePGCGRAFASATNYKNHVRIHTGEKPYVCTVPGCDKRFTEYSSLYKHHVVHTHSKPYNCNHCGKTYKQIS 444
Cdd:COG5048   32 RPDSC--PNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKA 105
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 397-454 5.29e-08

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 55.49  E-value: 5.29e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530395775 397 GEKPYVCTVPGCDKRFTEYSSLyKHHVVHTH--------------------SKPYNCNHCGKTYKQISTLAMHKRTAH 454
Cdd:COG5189  346 DGKPYKCPVEGCNKKYKNQNGL-KYHMLHGHqnqklhenpspekmnifsakDKPYRCEVCDKRYKNLNGLKYHRKHSH 422
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 263-427 1.29e-07

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 54.34  E-value: 1.29e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530395775 263 TTAHHLKVHERSHTGDRPYQCEHAGCGK---AFATGYGLKSHVRTHTGEKPYRCSEDNCTKSFKTSGDLQKHIrthtGER 339
Cdd:COG5189  273 SQGSAELFEESSLGFDYEFIHKSVGNKEirgGISTGEMIDVRKLPCTNSSSNGKLAHGGERNIDTPSRMLKVK----DGK 348

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530395775 340 PFKCPFEGCGRSFTTSNIRKVHvRTHTGERPYYCTEPgcgrafasatNYKNHVRIHTGEKPYVCTVpgCDKRFTEYSSLy 419
Cdd:COG5189  349 PYKCPVEGCNKKYKNQNGLKYH-MLHGHQNQKLHENP----------SPEKMNIFSAKDKPYRCEV--CDKRYKNLNGL- 414


                 ....*...
gi 530395775 420 KHHVVHTH 427
Cdd:COG5189  415 KYHRKHSH 422
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
278-336 2.54e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.46  E-value: 2.54e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 530395775 278 DRPYQCEhaGCGKAFATGYGLKSHVRTHTGEKPYRCSEDNCTKSFKTSGDLQKHIRTHT 336
Cdd:COG5048   31 PRPDSCP--NCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHH 87
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
373-456 7.91e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.92  E-value: 7.91e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530395775 373 CTEPGCGRAFASATNYKNHVR--IHTGE--KPYVCTVPGCDKRFTEYSSLYKHHVVHTHSKPYNC--NHCGKTYKQIST- 445
Cdd:COG5048  290 IKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNn 369

                         90
                 ....*....|....*
gi 530395775 446 ----LAMHKRTAHND 456
Cdd:COG5048  370 eppqSLQQYKDLKND 384
zf-H2C2_2 pfam13465
Zinc-finger double domain;
327-354 1.06e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.36  E-value: 1.06e-05
                          10        20
                  ....*....|....*....|....*...
gi 530395775  327 DLQKHIRTHTGERPFKCPFegCGRSFTT 354
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
246-422 1.35e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.15  E-value: 1.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530395775 246 SGEKAFRCEYDGCGKLYTTAHHLKVHERSHTGDRPYQCEHAGCGKafatgyglkshvrTHTGEKPYrcsednctksfKTS 325
Cdd:COG5048  317 ESLKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSS-------------KFSPLLNN-----------EPP 372

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530395775 326 GDLQKHIRTHTgERPFKCPFEGCGRSFTTSNIRKVHVRTHTGERPYYCTEPGCGRAFASATNYKNHVRIHTGEKPYVCtv 405
Cdd:COG5048  373 QSLQQYKDLKN-DKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC-- 449

                        170
                 ....*....|....*..
gi 530395775 406 pgCDKRFTEYSSLYKHH 422
Cdd:COG5048  450 --SILKSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
298-324 1.57e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.97  E-value: 1.57e-05
                          10        20
                  ....*....|....*....|....*..
gi 530395775  298 LKSHVRTHTGEKPYRCSEdnCTKSFKT 324
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPE--CGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
309-459 2.20e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.38  E-value: 2.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530395775 309 KPYRCseDNCTKSFKTSGDLQKHIRTHTGERPFKCPFEGCGRSFTTSNIRKVHVRTHTgERPYYCTEPGCGRAFASATNY 388
Cdd:COG5048   32 RPDSC--PNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHH-NNPSDLNSKSLPLSNSKASSS 108

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530395775 389 KNHvrIHTGEKPYVCTVPGCDKRFTEYSSLYKHHVVHTHS---KPYNCNHCGKTYKQISTLAMHKRTAHNDTEP 459
Cdd:COG5048  109 SLS--SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLrnnPLPGNNSSSVNTPQSNSLHPPLPANSLSKDP 180
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 283-370 3.12e-05

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 43.18  E-value: 3.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530395775  283 CEHAGCGKAFATGYGLKSHVRTHTGE------KPYRCSEDNCTKSFKTSGDLQKHIRTH-TGERPFKCpfEGCGRSFTT- 354
Cdd:pfam15909   2 CSSPGCCLSFPSVRDLAQHLRTHCPPtqslegKLFRCSALSCTETFPSMQELVAHSKLHyKPNRYFKC--ENCLLRFRTh 79

                          90
                  ....*....|....*..
gi 530395775  355 -SNIRKVHVRTHTGERP 370
Cdd:pfam15909  80 rSLFKHLHVCAEHAQSP 96
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 247-306 1.08e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.09  E-value: 1.08e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530395775 247 GEKAFRCEYDGCGKLYTTAHHLKVH---------------ERSHTG----DRPYQCEHagCGKAFATGYGLKSHvRTHT 306
Cdd:COG5189  346 DGKPYKCPVEGCNKKYKNQNGLKYHmlhghqnqklhenpsPEKMNIfsakDKPYRCEV--CDKRYKNLNGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
267-294 1.13e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 1.13e-04
                          10        20
                  ....*....|....*....|....*...
gi 530395775  267 HLKVHERSHTGDRPYQCEHagCGKAFAT 294
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
387-413 1.57e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.57e-04
                          10        20
                  ....*....|....*....|....*..
gi 530395775  387 NYKNHVRIHTGEKPYVCTVpgCDKRFT 413
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFK 25
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 313-429 1.03e-03

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 38.94  E-value: 1.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530395775  313 CSEDNCTKSFKTSGDLQKHIRTHTgerPFKCPFEGcgrsfttsnirkvhvrthtgeRPYYCTEPGCGRAFASATNYKNHV 392
Cdd:pfam15909   2 CSSPGCCLSFPSVRDLAQHLRTHC---PPTQSLEG---------------------KLFRCSALSCTETFPSMQELVAHS 57

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 530395775  393 RIHTGEKPYVcTVPGCDKRFTEYSSLYKH-HVVHTHSK 429
Cdd:pfam15909  58 KLHYKPNRYF-KCENCLLRFRTHRSLFKHlHVCAEHAQ 94
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 311-335 1.42e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.51  E-value: 1.42e-03
                          10        20
                  ....*....|....*....|....*
gi 530395775  311 YRCSEdnCTKSFKTSGDLQKHIRTH 335
Cdd:pfam00096   1 YKCPD--CGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
235-472 1.71e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 1.71e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530395775 235 HATRVTAKS-QQSGEKAFRCEY-DGCGKLYTTAHHLKVHERSHTGDRPYQCEHAGCGKAFATGYGLKSHVRTHTGEKPYR 312
Cdd:COG5048   14 SVLSSTPKStLKSLSNAPRPDScPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDL 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530395775 313 CSEDNCTKSFKTSGDL----------------------QKHIRTHTGERP---FKCPFEGCGRSFT----TSNIRKVHVR 363
Cdd:COG5048   94 NSKSLPLSNSKASSSSlsssssnsndnnllsshslppsSRDPQLPDLLSIsnlRNNPLPGNNSSSVntpqSNSLHPPLPA 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530395775 364 THTGERPYYCTEPGCGRAFASA--TNYKNHVRIHTGEKPYVCTVPGCDKRFTEYSSLYKHHVVHTHS---------KPYN 432
Cdd:COG5048  174 NSLSKDPSSNLSLLISSNVSTSipSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLlsqspsslsSSDS 253

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 530395775 433 CNHCGKTYKQISTLAMHKRTAHNDTEpiEEEQEAFFEPPP 472
Cdd:COG5048  254 SSSASESPRSSLPTASSQSSSPNESD--SSSEKGFSLPIK 291
zf-H2C2_2 pfam13465
Zinc-finger double domain;
359-384 1.95e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.95e-03
                          10        20
                  ....*....|....*....|....*.
gi 530395775  359 KVHVRTHTGERPYYCTEpgCGRAFAS 384
Cdd:pfam13465   3 KRHMRTHTGEKPYKCPE--CGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH