NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|530401197|ref|XP_005253892|]
View 

DNA oxidative demethylase ALKBH2 isoform X1 [Homo sapiens]

Protein Classification

2OG-Fe(II) oxygenase family protein( domain architecture ID 229412)

2OG-Fe(II) oxygenase family protein belongs to the large and diverse Fe(II)- and 2-oxoglutarate (2-OG)-dependent dioxygenase superfamily and may share a common reaction mechanism, using Fe(II) and the cosubstrate 2-OG in the active site to activate oxygen, resulting in the two-electron oxidation of a target substrate

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
AlkB COG3145
Alkylated DNA repair dioxygenase AlkB [Replication, recombination and repair];
72-256 6.75e-68

Alkylated DNA repair dioxygenase AlkB [Replication, recombination and repair];


:

Pssm-ID: 442379  Cd Length: 200  Bit Score: 208.47  E-value: 6.75e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530401197  72 LFGKAEADEIFQELEKEVEYFTgalARVQVFGKWHSVPRKQATYGDAGLTYTFSGLTLSPKPWIPVLERIRDHVSGVTGQ 151
Cdd:COG3145   24 FLSPEEADALLAALRAEAPWRQ---PVIPIFGKTMSVPRLNAWYGWVGAGYRYSGTDPEPPPWPPALLALKRRVEAAAGF 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530401197 152 TFNFVLINRYKDGCDHIGEHRDDERELAPGSPIASVSFGACRDFVFRHKDSRGKspsrrvaVVRLPLAHGSLLMMNHPTN 231
Cdd:COG3145  101 PFNSCLLNLYRDGQDRMGWHQDDEEELGFNPPIASVSLGATRRFRFGHKERKDP-------TRSLPLEHGDLLVMGGPTQ 173

                        170       180
                 ....*....|....*....|....*
gi 530401197 232 THWYHSLPVRKKVLAPRVNLTFRKI 256
Cdd:COG3145  174 LAWQHGVPKTKKGTGPRINLTFRRI 198
 
Name Accession Description Interval E-value
AlkB COG3145
Alkylated DNA repair dioxygenase AlkB [Replication, recombination and repair];
72-256 6.75e-68

Alkylated DNA repair dioxygenase AlkB [Replication, recombination and repair];


Pssm-ID: 442379  Cd Length: 200  Bit Score: 208.47  E-value: 6.75e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530401197  72 LFGKAEADEIFQELEKEVEYFTgalARVQVFGKWHSVPRKQATYGDAGLTYTFSGLTLSPKPWIPVLERIRDHVSGVTGQ 151
Cdd:COG3145   24 FLSPEEADALLAALRAEAPWRQ---PVIPIFGKTMSVPRLNAWYGWVGAGYRYSGTDPEPPPWPPALLALKRRVEAAAGF 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530401197 152 TFNFVLINRYKDGCDHIGEHRDDERELAPGSPIASVSFGACRDFVFRHKDSRGKspsrrvaVVRLPLAHGSLLMMNHPTN 231
Cdd:COG3145  101 PFNSCLLNLYRDGQDRMGWHQDDEEELGFNPPIASVSLGATRRFRFGHKERKDP-------TRSLPLEHGDLLVMGGPTQ 173

                        170       180
                 ....*....|....*....|....*
gi 530401197 232 THWYHSLPVRKKVLAPRVNLTFRKI 256
Cdd:COG3145  174 LAWQHGVPKTKKGTGPRINLTFRRI 198
2OG-FeII_Oxy_2 pfam13532
2OG-Fe(II) oxygenase superfamily;
72-254 1.42e-30

2OG-Fe(II) oxygenase superfamily;


Pssm-ID: 433285  Cd Length: 191  Bit Score: 112.41  E-value: 1.42e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530401197   72 LFGKAEADEIFQELEKEVEYFTGALARVQVFGKWHSVPRKQATYGDaGLTYTFSGLT-LSPKPWIPVLERIRD------H 144
Cdd:pfam13532   8 FLSPEEAAELLRELLEEGPFRQPTTQGGRPMSVRMTNCGQLGWVTD-GPGYRYSGVDpVTGEPWPPFPEALLQlaerlaA 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530401197  145 VSGVTGQTFNFVLINRYKDGcDHIGEHRDDErELAPGSPIASVSFGACRDFVFRHKdsrgkspSRRVAVVRLPLAHGSLL 224
Cdd:pfam13532  87 EAGYPGWSPNACLVNFYRDG-ARMGLHQDRD-ESGPGAPIVSLSLGASATFRFGGK-------SRSDPTISLRLESGDVL 157

                         170       180       190
                  ....*....|....*....|....*....|....
gi 530401197  225 MMNHPTNTHWYHSLPVRK----KVLAPRVNLTFR 254
Cdd:pfam13532 158 VMGGESRLAYHGVPPIRRgthpLLGGGRINLTFR 191
PRK15401 PRK15401
DNA oxidative demethylase AlkB;
157-255 3.27e-05

DNA oxidative demethylase AlkB;


Pssm-ID: 237957  Cd Length: 213  Bit Score: 43.70  E-value: 3.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530401197 157 LINRYKDGCdHIGEHRD-DERELapGSPIASVSFGACRDFVF---RHKDsrgksPSRRVavvrlPLAHGSLLMMNHPTNT 232
Cdd:PRK15401 119 LINRYAPGA-KLSLHQDkDERDF--RAPIVSVSLGLPAVFQFgglKRSD-----PLQRI-----LLEHGDVVVWGGPSRL 185

                         90       100
                 ....*....|....*....|....*..
gi 530401197 233 HWYHSLPVRKKVL----APRVNLTFRK 255
Cdd:PRK15401 186 RYHGILPLKAGEHpltgECRINLTFRK 212
 
Name Accession Description Interval E-value
AlkB COG3145
Alkylated DNA repair dioxygenase AlkB [Replication, recombination and repair];
72-256 6.75e-68

Alkylated DNA repair dioxygenase AlkB [Replication, recombination and repair];


Pssm-ID: 442379  Cd Length: 200  Bit Score: 208.47  E-value: 6.75e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530401197  72 LFGKAEADEIFQELEKEVEYFTgalARVQVFGKWHSVPRKQATYGDAGLTYTFSGLTLSPKPWIPVLERIRDHVSGVTGQ 151
Cdd:COG3145   24 FLSPEEADALLAALRAEAPWRQ---PVIPIFGKTMSVPRLNAWYGWVGAGYRYSGTDPEPPPWPPALLALKRRVEAAAGF 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530401197 152 TFNFVLINRYKDGCDHIGEHRDDERELAPGSPIASVSFGACRDFVFRHKDSRGKspsrrvaVVRLPLAHGSLLMMNHPTN 231
Cdd:COG3145  101 PFNSCLLNLYRDGQDRMGWHQDDEEELGFNPPIASVSLGATRRFRFGHKERKDP-------TRSLPLEHGDLLVMGGPTQ 173

                        170       180
                 ....*....|....*....|....*
gi 530401197 232 THWYHSLPVRKKVLAPRVNLTFRKI 256
Cdd:COG3145  174 LAWQHGVPKTKKGTGPRINLTFRRI 198
2OG-FeII_Oxy_2 pfam13532
2OG-Fe(II) oxygenase superfamily;
72-254 1.42e-30

2OG-Fe(II) oxygenase superfamily;


Pssm-ID: 433285  Cd Length: 191  Bit Score: 112.41  E-value: 1.42e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530401197   72 LFGKAEADEIFQELEKEVEYFTGALARVQVFGKWHSVPRKQATYGDaGLTYTFSGLT-LSPKPWIPVLERIRD------H 144
Cdd:pfam13532   8 FLSPEEAAELLRELLEEGPFRQPTTQGGRPMSVRMTNCGQLGWVTD-GPGYRYSGVDpVTGEPWPPFPEALLQlaerlaA 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530401197  145 VSGVTGQTFNFVLINRYKDGcDHIGEHRDDErELAPGSPIASVSFGACRDFVFRHKdsrgkspSRRVAVVRLPLAHGSLL 224
Cdd:pfam13532  87 EAGYPGWSPNACLVNFYRDG-ARMGLHQDRD-ESGPGAPIVSLSLGASATFRFGGK-------SRSDPTISLRLESGDVL 157

                         170       180       190
                  ....*....|....*....|....*....|....
gi 530401197  225 MMNHPTNTHWYHSLPVRK----KVLAPRVNLTFR 254
Cdd:pfam13532 158 VMGGESRLAYHGVPPIRRgthpLLGGGRINLTFR 191
PRK15401 PRK15401
DNA oxidative demethylase AlkB;
157-255 3.27e-05

DNA oxidative demethylase AlkB;


Pssm-ID: 237957  Cd Length: 213  Bit Score: 43.70  E-value: 3.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530401197 157 LINRYKDGCdHIGEHRD-DERELapGSPIASVSFGACRDFVF---RHKDsrgksPSRRVavvrlPLAHGSLLMMNHPTNT 232
Cdd:PRK15401 119 LINRYAPGA-KLSLHQDkDERDF--RAPIVSVSLGLPAVFQFgglKRSD-----PLQRI-----LLEHGDVVVWGGPSRL 185

                         90       100
                 ....*....|....*....|....*..
gi 530401197 233 HWYHSLPVRKKVL----APRVNLTFRK 255
Cdd:PRK15401 186 RYHGILPLKAGEHpltgECRINLTFRK 212
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH