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Conserved domains on  [gi|530405670|ref|XP_005254354|]
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RNA polymerase II-associated protein 1 isoform X1 [Homo sapiens]

Protein Classification

RPAP1 family protein( domain architecture ID 10554390)

RPAP1 family protein similar to human RNA polymerase II-associated protein 1 (RPAP1) that is required for interaction of the RNA polymerase II complex with acetylated histone H3

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RPAP1_C pfam08620
RPAP1-like, C-terminal; Inhibition of RPAP1 synthesis in Saccharomyces cerevisiae results in ...
 356-421 8.82e-28

RPAP1-like, C-terminal; Inhibition of RPAP1 synthesis in Saccharomyces cerevisiae results in changes in global gene expression that are similar to those caused by the loss of the RNAPII subunit Rpb11. This entry represents the C-terminal region that contains the motif GLHHH. This region is conserved from yeast to humans.


:

Pssm-ID: 462538  Cd Length: 69  Bit Score: 107.24  E-value: 8.82e-28
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530405670   356 QARFSLQGELLAP--DVDLPTHLGLHHHGEEAERAGYSLQELFHLTRSQVSQQRALALHVLAQVISRA 421
Cdd:pfam08620    1 ELRFDFKGNLIPPseSSDIPTHLGLHHHGDDPEAAGYTLPELAHLSRSTVPAQRCIALQTLGRILYKL 68
RPAP1_N pfam08621
RPAP1-like, N-terminal; Inhibition of RPAP1 synthesis in Saccharomyces cerevisiae results in ...
 225-270 1.76e-16

RPAP1-like, N-terminal; Inhibition of RPAP1 synthesis in Saccharomyces cerevisiae results in changes in global gene expression that are similar to those caused by the loss of the RNAPII subunit Rpb11. This entry represents the N-terminal region of RPAP-1 that is conserved from yeast to humans.


:

Pssm-ID: 462539 [Multi-domain]  Cd Length: 46  Bit Score: 74.47  E-value: 1.76e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 530405670   225 QTIHEENIARLQAMAPEEILQEQQRLLAQLDPSLVAFLRSHSHTQE 270
Cdd:pfam08621    1 QRIDEENRARLASMSPEEIEEEREELLESLDPKLLEFLLKRANKKE 46
 
Name Accession Description Interval E-value
RPAP1_C pfam08620
RPAP1-like, C-terminal; Inhibition of RPAP1 synthesis in Saccharomyces cerevisiae results in ...
 356-421 8.82e-28

RPAP1-like, C-terminal; Inhibition of RPAP1 synthesis in Saccharomyces cerevisiae results in changes in global gene expression that are similar to those caused by the loss of the RNAPII subunit Rpb11. This entry represents the C-terminal region that contains the motif GLHHH. This region is conserved from yeast to humans.


Pssm-ID: 462538  Cd Length: 69  Bit Score: 107.24  E-value: 8.82e-28
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530405670   356 QARFSLQGELLAP--DVDLPTHLGLHHHGEEAERAGYSLQELFHLTRSQVSQQRALALHVLAQVISRA 421
Cdd:pfam08620    1 ELRFDFKGNLIPPseSSDIPTHLGLHHHGDDPEAAGYTLPELAHLSRSTVPAQRCIALQTLGRILYKL 68
RPAP1_N pfam08621
RPAP1-like, N-terminal; Inhibition of RPAP1 synthesis in Saccharomyces cerevisiae results in ...
 225-270 1.76e-16

RPAP1-like, N-terminal; Inhibition of RPAP1 synthesis in Saccharomyces cerevisiae results in changes in global gene expression that are similar to those caused by the loss of the RNAPII subunit Rpb11. This entry represents the N-terminal region of RPAP-1 that is conserved from yeast to humans.


Pssm-ID: 462539 [Multi-domain]  Cd Length: 46  Bit Score: 74.47  E-value: 1.76e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 530405670   225 QTIHEENIARLQAMAPEEILQEQQRLLAQLDPSLVAFLRSHSHTQE 270
Cdd:pfam08621    1 QRIDEENRARLASMSPEEIEEEREELLESLDPKLLEFLLKRANKKE 46
 
Name Accession Description Interval E-value
RPAP1_C pfam08620
RPAP1-like, C-terminal; Inhibition of RPAP1 synthesis in Saccharomyces cerevisiae results in ...
 356-421 8.82e-28

RPAP1-like, C-terminal; Inhibition of RPAP1 synthesis in Saccharomyces cerevisiae results in changes in global gene expression that are similar to those caused by the loss of the RNAPII subunit Rpb11. This entry represents the C-terminal region that contains the motif GLHHH. This region is conserved from yeast to humans.


Pssm-ID: 462538  Cd Length: 69  Bit Score: 107.24  E-value: 8.82e-28
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530405670   356 QARFSLQGELLAP--DVDLPTHLGLHHHGEEAERAGYSLQELFHLTRSQVSQQRALALHVLAQVISRA 421
Cdd:pfam08620    1 ELRFDFKGNLIPPseSSDIPTHLGLHHHGDDPEAAGYTLPELAHLSRSTVPAQRCIALQTLGRILYKL 68
RPAP1_N pfam08621
RPAP1-like, N-terminal; Inhibition of RPAP1 synthesis in Saccharomyces cerevisiae results in ...
 225-270 1.76e-16

RPAP1-like, N-terminal; Inhibition of RPAP1 synthesis in Saccharomyces cerevisiae results in changes in global gene expression that are similar to those caused by the loss of the RNAPII subunit Rpb11. This entry represents the N-terminal region of RPAP-1 that is conserved from yeast to humans.


Pssm-ID: 462539 [Multi-domain]  Cd Length: 46  Bit Score: 74.47  E-value: 1.76e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 530405670   225 QTIHEENIARLQAMAPEEILQEQQRLLAQLDPSLVAFLRSHSHTQE 270
Cdd:pfam08621    1 QRIDEENRARLASMSPEEIEEEREELLESLDPKLLEFLLKRANKKE 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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