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Conserved domains on  [gi|530407082|ref|XP_005254944|]
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vacuolar protein sorting-associated protein 33B isoform X1 [Homo sapiens]

Protein Classification

Sec1 family protein( domain architecture ID 10469995)

Sec1 family protein such as syntaxin-binding proteins, which participate in the regulation of synaptic vesicle docking and fusion, and vacuolar protein sorting-associated protein 33A/33B/45, which play a role in vesicle-mediated protein trafficking from the Golgi stack through the trans-Golgi network

CATH:  3.40.50.1910
PubMed:  8769846|15642380
SCOP:  4002933

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Sec1 pfam00995
Sec1 family;
12-519 7.34e-72

Sec1 family;


:

Pssm-ID: 460020  Cd Length: 506  Bit Score: 237.60  E-value: 7.34e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530407082   12 KLAGRTRKYKVIFSPQKfyaCEMVLEE--EGIYGDVSCDEWAFSLLPLDVDLLSM---ELPEFFRDYFLE-GDQRW---I 82
Cdd:pfam00995  65 SSRPKYKSYHIFFTSRL---SRELLEGlaEGDEVVKKVKEINLDFIPLESDLFSLndpELPLYFPSYYLDlNDPVWldeL 141
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530407082   83 NTVAQALH-LLSTLyGPFPNCYGIGRCAKM-AYELWRNLEEEEDGETKGRRPEIGHIFLLDRDVDFVTALCSQVVYEGLV 160
Cdd:pfam00995 142 DRIAKGLLsVCLTL-GEIPIIRYKGPAAEMvAKKLADKLRDKIDSFAKLSSDSRPVLIILDRSVDLVTPLLHQWTYQALV 220
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530407082  161 DDTF-RIKCGSVDFGPEVTSSDKSLKVLLNaEDKVFNEIRNEHFSNVFGFLSQKARNLQAQYDRRR----GMDIKQMKNF 235
Cdd:pfam00995 221 HDLLgILKLNRVTLETGGKEEEKKVELLDS-SDPFWVENRHLHFADVGEKLKKKLKEYKAKNKETRktkgIASIADLKDF 299
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530407082  236 VSQeLKGLKQEHRLLSLHIGACESIMKKKTKQDFQELIKTEHALLEGFNIRESTSYIEEHI---DRQVSPIESLRLMCLL 312
Cdd:pfam00995 300 VAK-LPELQEEKRKLSLHTNLAEELLKIIKKRKLDELLELEQDLATGEDSKQKDKLIEELIallDADVSPLDKLRLLLLY 378
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530407082  313 SITENGlIPKDYRSLKTQYLQS-YGpehlltfsnlrragllteqapgdtltaveskvsklvtdkaagkitdafsslakrs 391
Cdd:pfam00995 379 SLTENG-KSKELEDLKRELLQAiYG------------------------------------------------------- 402
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530407082  392 nfraiskklnliprvdgeydlkvprdmayvfggaYVPLSCRIIEQVLERRSWQGLDEVVRLLNCSDFAFTDMTKEDKAS- 470
Cdd:pfam00995 403 ----------------------------------YVPLLTRLVEALIKGGLLSSEFPSLKPPDPLGADLSGSVSARSKSg 448
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 530407082  471 --------SESLRLILVVFLGGCTFSEISALRFLGREKGYRFIFLTTAVTNSARLME 519
Cdd:pfam00995 449 assggsrrSSFRQRVIVFVVGGVTYSEIRALRELAKKKNKEIIIGSTSILNPNSFLE 505
 
Name Accession Description Interval E-value
Sec1 pfam00995
Sec1 family;
12-519 7.34e-72

Sec1 family;


Pssm-ID: 460020  Cd Length: 506  Bit Score: 237.60  E-value: 7.34e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530407082   12 KLAGRTRKYKVIFSPQKfyaCEMVLEE--EGIYGDVSCDEWAFSLLPLDVDLLSM---ELPEFFRDYFLE-GDQRW---I 82
Cdd:pfam00995  65 SSRPKYKSYHIFFTSRL---SRELLEGlaEGDEVVKKVKEINLDFIPLESDLFSLndpELPLYFPSYYLDlNDPVWldeL 141
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530407082   83 NTVAQALH-LLSTLyGPFPNCYGIGRCAKM-AYELWRNLEEEEDGETKGRRPEIGHIFLLDRDVDFVTALCSQVVYEGLV 160
Cdd:pfam00995 142 DRIAKGLLsVCLTL-GEIPIIRYKGPAAEMvAKKLADKLRDKIDSFAKLSSDSRPVLIILDRSVDLVTPLLHQWTYQALV 220
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530407082  161 DDTF-RIKCGSVDFGPEVTSSDKSLKVLLNaEDKVFNEIRNEHFSNVFGFLSQKARNLQAQYDRRR----GMDIKQMKNF 235
Cdd:pfam00995 221 HDLLgILKLNRVTLETGGKEEEKKVELLDS-SDPFWVENRHLHFADVGEKLKKKLKEYKAKNKETRktkgIASIADLKDF 299
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530407082  236 VSQeLKGLKQEHRLLSLHIGACESIMKKKTKQDFQELIKTEHALLEGFNIRESTSYIEEHI---DRQVSPIESLRLMCLL 312
Cdd:pfam00995 300 VAK-LPELQEEKRKLSLHTNLAEELLKIIKKRKLDELLELEQDLATGEDSKQKDKLIEELIallDADVSPLDKLRLLLLY 378
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530407082  313 SITENGlIPKDYRSLKTQYLQS-YGpehlltfsnlrragllteqapgdtltaveskvsklvtdkaagkitdafsslakrs 391
Cdd:pfam00995 379 SLTENG-KSKELEDLKRELLQAiYG------------------------------------------------------- 402
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530407082  392 nfraiskklnliprvdgeydlkvprdmayvfggaYVPLSCRIIEQVLERRSWQGLDEVVRLLNCSDFAFTDMTKEDKAS- 470
Cdd:pfam00995 403 ----------------------------------YVPLLTRLVEALIKGGLLSSEFPSLKPPDPLGADLSGSVSARSKSg 448
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 530407082  471 --------SESLRLILVVFLGGCTFSEISALRFLGREKGYRFIFLTTAVTNSARLME 519
Cdd:pfam00995 449 assggsrrSSFRQRVIVFVVGGVTYSEIRALRELAKKKNKEIIIGSTSILNPNSFLE 505
SEC1 COG5158
Proteins involved in synaptic transmission and general secretion, Sec1 family [Intracellular ...
15-522 1.83e-49

Proteins involved in synaptic transmission and general secretion, Sec1 family [Intracellular trafficking and secretion];


Pssm-ID: 227487  Cd Length: 582  Bit Score: 179.15  E-value: 1.83e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530407082  15 GRTRKYKVIFSPQKFYACEMVLEEEGIYGDV-SCDEWAFSLLPLDVDLLSMELPEFFRDYFLEGDQRWINTVAQALH--L 91
Cdd:COG5158   93 PFYLNYHISFLNTVTESLLELLAESGVFEKIlSVYEIYLDFFVLESDLFSLNLPESFLESSLPSTTEALIKIVNGLFslC 172
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530407082  92 LSTLYGPFPNCYGIGRCAKMAYELWRNLEEEED---GETKGRRPEIGHIFLLDRDVDFVTALCSQVVYEGLVDDTFRIKC 168
Cdd:COG5158  173 VSLGRIPIIRYSGGKNAEHMAKKLSDEIRNELSinfDGVVSKNPLRPILIILDRSLDPITPLLHQWTYQAMLHDLLGINN 252
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530407082 169 GSVDFGPEVTSSDKSLKVLLNAEDKVFNEIRNEHFSNVFGFLSQKARNLQAQYDRR---RGMDIKQMKNFVSqELKGLKQ 245
Cdd:COG5158  253 NIVTIPSSSVNGPEKKFSLSDKDDPFWNDNKFLNFGEVGEKLKKLAKELKTKAQLRhkeNAKSVNDIKEFVD-KLPELQK 331
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530407082 246 EHRLLSLHIGACESIMKKKTKQDFQELIKTEHALLEGFNIRESTSYIEEHIDRQVSPIESLRLMCLLSITENGLIpKDYR 325
Cdd:COG5158  332 RSRSLNKHLTLASELLKVVEERYLDDFSEIEQNLSTGNDVKSDISDLIELLESGVEEDDKLRLLILYSLTKDGLI-KDID 410
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530407082 326 SLKTQYLQSYGPEHLLTFSNLRRAGLLTEQAPGDTLTaveskvsklvtdkaagkitdafsslaKRSNFRAISKKLNLIPR 405
Cdd:COG5158  411 ELRLLRIQGYGIEALNFFQRLKELGFLTLKDSKTISL--------------------------KRGDKDSLFQWFNTYSL 464
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530407082 406 VDgeyDLKVPRDMAYVFGGaYVPLSCRIIEQVLERRSwqgLDEVVRLLNCSDFAFTDMTKEDKASSESLRLILVVFLGGC 485
Cdd:COG5158  465 SR---EHQGVPDLENVYSG-LIPLKKDIPIDLLVRRL---FEPLKSSQQQSLRLSRPKGRSRSNKKIPQQRILVFVIGGV 537
                        490       500       510
                 ....*....|....*....|....*....|....*...
gi 530407082 486 TFSEISALR-FLGREKGYRFIFLTTAVTNSARLMEAMS 522
Cdd:COG5158  538 TYEELRVLYeLNESQNSVRIIYGSTEILTPAEFLDEVK 575
 
Name Accession Description Interval E-value
Sec1 pfam00995
Sec1 family;
12-519 7.34e-72

Sec1 family;


Pssm-ID: 460020  Cd Length: 506  Bit Score: 237.60  E-value: 7.34e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530407082   12 KLAGRTRKYKVIFSPQKfyaCEMVLEE--EGIYGDVSCDEWAFSLLPLDVDLLSM---ELPEFFRDYFLE-GDQRW---I 82
Cdd:pfam00995  65 SSRPKYKSYHIFFTSRL---SRELLEGlaEGDEVVKKVKEINLDFIPLESDLFSLndpELPLYFPSYYLDlNDPVWldeL 141
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530407082   83 NTVAQALH-LLSTLyGPFPNCYGIGRCAKM-AYELWRNLEEEEDGETKGRRPEIGHIFLLDRDVDFVTALCSQVVYEGLV 160
Cdd:pfam00995 142 DRIAKGLLsVCLTL-GEIPIIRYKGPAAEMvAKKLADKLRDKIDSFAKLSSDSRPVLIILDRSVDLVTPLLHQWTYQALV 220
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530407082  161 DDTF-RIKCGSVDFGPEVTSSDKSLKVLLNaEDKVFNEIRNEHFSNVFGFLSQKARNLQAQYDRRR----GMDIKQMKNF 235
Cdd:pfam00995 221 HDLLgILKLNRVTLETGGKEEEKKVELLDS-SDPFWVENRHLHFADVGEKLKKKLKEYKAKNKETRktkgIASIADLKDF 299
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530407082  236 VSQeLKGLKQEHRLLSLHIGACESIMKKKTKQDFQELIKTEHALLEGFNIRESTSYIEEHI---DRQVSPIESLRLMCLL 312
Cdd:pfam00995 300 VAK-LPELQEEKRKLSLHTNLAEELLKIIKKRKLDELLELEQDLATGEDSKQKDKLIEELIallDADVSPLDKLRLLLLY 378
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530407082  313 SITENGlIPKDYRSLKTQYLQS-YGpehlltfsnlrragllteqapgdtltaveskvsklvtdkaagkitdafsslakrs 391
Cdd:pfam00995 379 SLTENG-KSKELEDLKRELLQAiYG------------------------------------------------------- 402
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530407082  392 nfraiskklnliprvdgeydlkvprdmayvfggaYVPLSCRIIEQVLERRSWQGLDEVVRLLNCSDFAFTDMTKEDKAS- 470
Cdd:pfam00995 403 ----------------------------------YVPLLTRLVEALIKGGLLSSEFPSLKPPDPLGADLSGSVSARSKSg 448
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 530407082  471 --------SESLRLILVVFLGGCTFSEISALRFLGREKGYRFIFLTTAVTNSARLME 519
Cdd:pfam00995 449 assggsrrSSFRQRVIVFVVGGVTYSEIRALRELAKKKNKEIIIGSTSILNPNSFLE 505
SEC1 COG5158
Proteins involved in synaptic transmission and general secretion, Sec1 family [Intracellular ...
15-522 1.83e-49

Proteins involved in synaptic transmission and general secretion, Sec1 family [Intracellular trafficking and secretion];


Pssm-ID: 227487  Cd Length: 582  Bit Score: 179.15  E-value: 1.83e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530407082  15 GRTRKYKVIFSPQKFYACEMVLEEEGIYGDV-SCDEWAFSLLPLDVDLLSMELPEFFRDYFLEGDQRWINTVAQALH--L 91
Cdd:COG5158   93 PFYLNYHISFLNTVTESLLELLAESGVFEKIlSVYEIYLDFFVLESDLFSLNLPESFLESSLPSTTEALIKIVNGLFslC 172
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530407082  92 LSTLYGPFPNCYGIGRCAKMAYELWRNLEEEED---GETKGRRPEIGHIFLLDRDVDFVTALCSQVVYEGLVDDTFRIKC 168
Cdd:COG5158  173 VSLGRIPIIRYSGGKNAEHMAKKLSDEIRNELSinfDGVVSKNPLRPILIILDRSLDPITPLLHQWTYQAMLHDLLGINN 252
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530407082 169 GSVDFGPEVTSSDKSLKVLLNAEDKVFNEIRNEHFSNVFGFLSQKARNLQAQYDRR---RGMDIKQMKNFVSqELKGLKQ 245
Cdd:COG5158  253 NIVTIPSSSVNGPEKKFSLSDKDDPFWNDNKFLNFGEVGEKLKKLAKELKTKAQLRhkeNAKSVNDIKEFVD-KLPELQK 331
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530407082 246 EHRLLSLHIGACESIMKKKTKQDFQELIKTEHALLEGFNIRESTSYIEEHIDRQVSPIESLRLMCLLSITENGLIpKDYR 325
Cdd:COG5158  332 RSRSLNKHLTLASELLKVVEERYLDDFSEIEQNLSTGNDVKSDISDLIELLESGVEEDDKLRLLILYSLTKDGLI-KDID 410
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530407082 326 SLKTQYLQSYGPEHLLTFSNLRRAGLLTEQAPGDTLTaveskvsklvtdkaagkitdafsslaKRSNFRAISKKLNLIPR 405
Cdd:COG5158  411 ELRLLRIQGYGIEALNFFQRLKELGFLTLKDSKTISL--------------------------KRGDKDSLFQWFNTYSL 464
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530407082 406 VDgeyDLKVPRDMAYVFGGaYVPLSCRIIEQVLERRSwqgLDEVVRLLNCSDFAFTDMTKEDKASSESLRLILVVFLGGC 485
Cdd:COG5158  465 SR---EHQGVPDLENVYSG-LIPLKKDIPIDLLVRRL---FEPLKSSQQQSLRLSRPKGRSRSNKKIPQQRILVFVIGGV 537
                        490       500       510
                 ....*....|....*....|....*....|....*...
gi 530407082 486 TFSEISALR-FLGREKGYRFIFLTTAVTNSARLMEAMS 522
Cdd:COG5158  538 TYEELRVLYeLNESQNSVRIIYGSTEILTPAEFLDEVK 575
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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