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Conserved domains on  [gi|530407976|ref|XP_005255336|]
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ubinuclein-1 isoform X3 [Homo sapiens]

Protein Classification

HUN and UBN_AB domain-containing protein( domain architecture ID 10555281)

HUN and UBN_AB domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UBN_AB pfam14075
Ubinuclein conserved middle domain; Ubinuclein 1 and 2 (UBN1, UBN2) are members of a histone ...
 353-525 9.47e-67

Ubinuclein conserved middle domain; Ubinuclein 1 and 2 (UBN1, UBN2) are members of a histone chaperone complex involved in the formation of a certain type of facultative heterochromatin, called senescence-associated heterochromatin foci (SAHF). The domain described here is conserved in many eukaryotes such as human, rat, drosophila, and zebra-fish and has been targeted for protein structure determination by the Joint Center for Structural Genomics.


:

Pssm-ID: 464081  Cd Length: 212  Bit Score: 223.72  E-value: 9.47e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530407976   353 LPEGLPAPLEKRVKELAQAARAAEGESRQKFFTQDINGILLDIEAQTRELSSQVRSGVYAYLASFLPCSKDALLKRARKL 432
Cdd:pfam14075    1 LPESLPAELQEAIESLKEAAKSSDAEGKKNFFDPELNPLLLDIELQARCLGTNYRSNVYAHLESFLPCNKDTLLKRAKKL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530407976   433 HLYEQGGRLKEPLQKLKEAIGRAMPEQMAKYQDECQAHTQAKVAKMLEEEKDKEQRDricsdeeeDEEKGGRRIMGPRKK 512
Cdd:pfam14075   81 RLKEEDDRLKEPLEKLKEAIDEVMPEQIAKYELECQAWAEAKAAKKAEDGPDTDEDD--------DDEKKEKRPKGPRKK 152

                          170
                   ....*....|...
gi 530407976   513 FQWNDEIRTLFKE 525
Cdd:pfam14075  153 FQWNEELRTLLWD 165
HUN pfam08729
HPC2 and ubinuclein domain; HPC2 (Histone promoter control 2) is required for cell-cycle ...
 117-168 3.27e-23

HPC2 and ubinuclein domain; HPC2 (Histone promoter control 2) is required for cell-cycle regulation of histone transcription. It regulates transcription of the histone genes during the S-phase of the cell cycle by repressing transcription at other cell cycle stages. HPC2 mutants display synthetic interactions with FACT complex which allows RNA Pol II to elongate through nucleosomes. Hpc2 is one of the proteins of one of the multi-subunit complexes that mediate replication- independent nucleosome assembly, along with histone chaperone proteins. the Hip4 sequence from SCH. pombe is an integral component of this complex that is required for transcriptional silencing at multiple loci. HPC2, ubinuclein/yemanuclein, and the cell cycle regulator FLJ25778 share a conserved domain that is predicted to bind histone tails. This domain is also referred to as the HRD or Hpc2-related domain.


:

Pssm-ID: 462581 [Multi-domain]  Cd Length: 52  Bit Score: 93.49  E-value: 3.27e-23
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 530407976   117 RRKDRIQDLIDMGYGYDESDSFIDNSEAYDELVPASLTTKYGGFYINSGTLQ 168
Cdd:pfam08729    1 KRRKRKDDYADDGMGYDEEDPFIDDSELYDELVPSELTTKHGGFYVNSGELE 52
 
Name Accession Description Interval E-value
UBN_AB pfam14075
Ubinuclein conserved middle domain; Ubinuclein 1 and 2 (UBN1, UBN2) are members of a histone ...
 353-525 9.47e-67

Ubinuclein conserved middle domain; Ubinuclein 1 and 2 (UBN1, UBN2) are members of a histone chaperone complex involved in the formation of a certain type of facultative heterochromatin, called senescence-associated heterochromatin foci (SAHF). The domain described here is conserved in many eukaryotes such as human, rat, drosophila, and zebra-fish and has been targeted for protein structure determination by the Joint Center for Structural Genomics.


Pssm-ID: 464081  Cd Length: 212  Bit Score: 223.72  E-value: 9.47e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530407976   353 LPEGLPAPLEKRVKELAQAARAAEGESRQKFFTQDINGILLDIEAQTRELSSQVRSGVYAYLASFLPCSKDALLKRARKL 432
Cdd:pfam14075    1 LPESLPAELQEAIESLKEAAKSSDAEGKKNFFDPELNPLLLDIELQARCLGTNYRSNVYAHLESFLPCNKDTLLKRAKKL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530407976   433 HLYEQGGRLKEPLQKLKEAIGRAMPEQMAKYQDECQAHTQAKVAKMLEEEKDKEQRDricsdeeeDEEKGGRRIMGPRKK 512
Cdd:pfam14075   81 RLKEEDDRLKEPLEKLKEAIDEVMPEQIAKYELECQAWAEAKAAKKAEDGPDTDEDD--------DDEKKEKRPKGPRKK 152

                          170
                   ....*....|...
gi 530407976   513 FQWNDEIRTLFKE 525
Cdd:pfam14075  153 FQWNEELRTLLWD 165
HUN pfam08729
HPC2 and ubinuclein domain; HPC2 (Histone promoter control 2) is required for cell-cycle ...
 117-168 3.27e-23

HPC2 and ubinuclein domain; HPC2 (Histone promoter control 2) is required for cell-cycle regulation of histone transcription. It regulates transcription of the histone genes during the S-phase of the cell cycle by repressing transcription at other cell cycle stages. HPC2 mutants display synthetic interactions with FACT complex which allows RNA Pol II to elongate through nucleosomes. Hpc2 is one of the proteins of one of the multi-subunit complexes that mediate replication- independent nucleosome assembly, along with histone chaperone proteins. the Hip4 sequence from SCH. pombe is an integral component of this complex that is required for transcriptional silencing at multiple loci. HPC2, ubinuclein/yemanuclein, and the cell cycle regulator FLJ25778 share a conserved domain that is predicted to bind histone tails. This domain is also referred to as the HRD or Hpc2-related domain.


Pssm-ID: 462581 [Multi-domain]  Cd Length: 52  Bit Score: 93.49  E-value: 3.27e-23
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 530407976   117 RRKDRIQDLIDMGYGYDESDSFIDNSEAYDELVPASLTTKYGGFYINSGTLQ 168
Cdd:pfam08729    1 KRRKRKDDYADDGMGYDEEDPFIDDSELYDELVPSELTTKHGGFYVNSGELE 52
 
Name Accession Description Interval E-value
UBN_AB pfam14075
Ubinuclein conserved middle domain; Ubinuclein 1 and 2 (UBN1, UBN2) are members of a histone ...
 353-525 9.47e-67

Ubinuclein conserved middle domain; Ubinuclein 1 and 2 (UBN1, UBN2) are members of a histone chaperone complex involved in the formation of a certain type of facultative heterochromatin, called senescence-associated heterochromatin foci (SAHF). The domain described here is conserved in many eukaryotes such as human, rat, drosophila, and zebra-fish and has been targeted for protein structure determination by the Joint Center for Structural Genomics.


Pssm-ID: 464081  Cd Length: 212  Bit Score: 223.72  E-value: 9.47e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530407976   353 LPEGLPAPLEKRVKELAQAARAAEGESRQKFFTQDINGILLDIEAQTRELSSQVRSGVYAYLASFLPCSKDALLKRARKL 432
Cdd:pfam14075    1 LPESLPAELQEAIESLKEAAKSSDAEGKKNFFDPELNPLLLDIELQARCLGTNYRSNVYAHLESFLPCNKDTLLKRAKKL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530407976   433 HLYEQGGRLKEPLQKLKEAIGRAMPEQMAKYQDECQAHTQAKVAKMLEEEKDKEQRDricsdeeeDEEKGGRRIMGPRKK 512
Cdd:pfam14075   81 RLKEEDDRLKEPLEKLKEAIDEVMPEQIAKYELECQAWAEAKAAKKAEDGPDTDEDD--------DDEKKEKRPKGPRKK 152

                          170
                   ....*....|...
gi 530407976   513 FQWNDEIRTLFKE 525
Cdd:pfam14075  153 FQWNEELRTLLWD 165
HUN pfam08729
HPC2 and ubinuclein domain; HPC2 (Histone promoter control 2) is required for cell-cycle ...
 117-168 3.27e-23

HPC2 and ubinuclein domain; HPC2 (Histone promoter control 2) is required for cell-cycle regulation of histone transcription. It regulates transcription of the histone genes during the S-phase of the cell cycle by repressing transcription at other cell cycle stages. HPC2 mutants display synthetic interactions with FACT complex which allows RNA Pol II to elongate through nucleosomes. Hpc2 is one of the proteins of one of the multi-subunit complexes that mediate replication- independent nucleosome assembly, along with histone chaperone proteins. the Hip4 sequence from SCH. pombe is an integral component of this complex that is required for transcriptional silencing at multiple loci. HPC2, ubinuclein/yemanuclein, and the cell cycle regulator FLJ25778 share a conserved domain that is predicted to bind histone tails. This domain is also referred to as the HRD or Hpc2-related domain.


Pssm-ID: 462581 [Multi-domain]  Cd Length: 52  Bit Score: 93.49  E-value: 3.27e-23
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 530407976   117 RRKDRIQDLIDMGYGYDESDSFIDNSEAYDELVPASLTTKYGGFYINSGTLQ 168
Cdd:pfam08729    1 KRRKRKDDYADDGMGYDEEDPFIDDSELYDELVPSELTTKHGGFYVNSGELE 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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