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Conserved domains on  [gi|530408880|ref|XP_005255536|]
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target of rapamycin complex subunit LST8 isoform X3 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
10-326 3.56e-57

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 190.12  E-value: 3.56e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408880  10 SDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAvqpvslGYQH-IRMYDLNSnnPNPIISYD 88
Cdd:COG2319   88 PDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASG------SADGtVRLWDLAT--GKLLRTLT 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408880  89 GVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRnlQCQRIFQV-NAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDH 167
Cdd:COG2319  160 GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG--KLLRTLTGhTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGK 237

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408880 168 NEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGigdevtQLIpkTKIPAHTRYALQCRFSPDSTLLATCSAD 247
Cdd:COG2319  238 LLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG------ELL--RTLTGHSGGVNSVAFSPDGKLLASGSDD 309

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530408880 248 QTCKIWRTSNFSLMTELSiksgnpgeSSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAF 326
Cdd:COG2319  310 GTVRLWDLATGKLLRTLT--------GHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAF 380
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
10-326 3.56e-57

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 190.12  E-value: 3.56e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408880  10 SDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAvqpvslGYQH-IRMYDLNSnnPNPIISYD 88
Cdd:COG2319   88 PDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASG------SADGtVRLWDLAT--GKLLRTLT 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408880  89 GVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRnlQCQRIFQV-NAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDH 167
Cdd:COG2319  160 GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG--KLLRTLTGhTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGK 237

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408880 168 NEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGigdevtQLIpkTKIPAHTRYALQCRFSPDSTLLATCSAD 247
Cdd:COG2319  238 LLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG------ELL--RTLTGHSGGVNSVAFSPDGKLLASGSDD 309

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530408880 248 QTCKIWRTSNFSLMTELSiksgnpgeSSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAF 326
Cdd:COG2319  310 GTVRLWDLATGKLLRTLT--------GHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAF 380
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 14-303 8.34e-43

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 149.41  E-value: 8.34e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408880  14 ILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAvqpvSLGYQhIRMYDLNSNNPnpIISYDGVNKN 93
Cdd:cd00200   23 LLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASG----SSDKT-IRLWDLETGEC--VRTLTGHTSY 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408880  94 IASVGFHEDGRWMYTGGEDCTARIWDLRSRnlQCQRIFQ-VNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLI 172
Cdd:cd00200   96 VSSVAFSPDGRILSSSSRDKTIKVWDVETG--KCLTTLRgHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATL 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408880 173 PEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGigDEVTQLIpktkipAHTRYALQCRFSPDSTLLATCSADQTCKI 252
Cdd:cd00200  174 TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG--KCLGTLR------GHENGVNSVAFSPDGYLLASGSEDGTIRV 245

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 530408880 253 WRTSNFSLMTELSiksgnpgeSSRGWMWGCAFSGDSQYIVTASSDNLARLW 303
Cdd:cd00200  246 WDLRTGECVQTLS--------GHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 218-253 7.72e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 7.72e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 530408880   218 PKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIW 253
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
218-253 3.59e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 3.59e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 530408880  218 PKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIW 253
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
10-326 3.56e-57

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 190.12  E-value: 3.56e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408880  10 SDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAvqpvslGYQH-IRMYDLNSnnPNPIISYD 88
Cdd:COG2319   88 PDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASG------SADGtVRLWDLAT--GKLLRTLT 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408880  89 GVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRnlQCQRIFQV-NAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDH 167
Cdd:COG2319  160 GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG--KLLRTLTGhTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGK 237

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408880 168 NEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGigdevtQLIpkTKIPAHTRYALQCRFSPDSTLLATCSAD 247
Cdd:COG2319  238 LLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG------ELL--RTLTGHSGGVNSVAFSPDGKLLASGSDD 309

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530408880 248 QTCKIWRTSNFSLMTELSiksgnpgeSSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAF 326
Cdd:COG2319  310 GTVRLWDLATGKLLRTLT--------GHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAF 380
WD40 COG2319
WD40 repeat [General function prediction only];
14-303 1.31e-49

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 170.48  E-value: 1.31e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408880  14 ILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAvqpvsLGYQHIRMYDLNSNNPnpIISYDGVNKN 93
Cdd:COG2319  134 TLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASG-----SDDGTVRLWDLATGKL--LRTLTGHTGA 206

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408880  94 IASVGFHEDGRWMYTGGEDCTARIWDLRSRnlQCQRIFQV-NAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLI 172
Cdd:COG2319  207 VRSVAFSPDGKLLASGSADGTVRLWDLATG--KLLRTLTGhSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTL 284

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408880 173 PEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGigdevtQLIpkTKIPAHTRYALQCRFSPDSTLLATCSADQTCKI 252
Cdd:COG2319  285 TGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATG------KLL--RTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRL 356

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 530408880 253 WRTSNFSLMTELsiksgnpgESSRGWMWGCAFSGDSQYIVTASSDNLARLW 303
Cdd:COG2319  357 WDLATGELLRTL--------TGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 14-303 8.34e-43

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 149.41  E-value: 8.34e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408880  14 ILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAvqpvSLGYQhIRMYDLNSNNPnpIISYDGVNKN 93
Cdd:cd00200   23 LLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASG----SSDKT-IRLWDLETGEC--VRTLTGHTSY 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408880  94 IASVGFHEDGRWMYTGGEDCTARIWDLRSRnlQCQRIFQ-VNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLI 172
Cdd:cd00200   96 VSSVAFSPDGRILSSSSRDKTIKVWDVETG--KCLTTLRgHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATL 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408880 173 PEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGigDEVTQLIpktkipAHTRYALQCRFSPDSTLLATCSADQTCKI 252
Cdd:cd00200  174 TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG--KCLGTLR------GHENGVNSVAFSPDGYLLASGSEDGTIRV 245

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 530408880 253 WRTSNFSLMTELSiksgnpgeSSRGWMWGCAFSGDSQYIVTASSDNLARLW 303
Cdd:cd00200  246 WDLRTGECVQTLS--------GHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
8-326 1.39e-40

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 146.59  E-value: 1.39e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408880   8 VGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAVQPVSLGyqhirmyDLNSNNPNPIISY 87
Cdd:COG2319    2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLL-------LLDAAAGALLATL 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408880  88 DGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQcQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDH 167
Cdd:COG2319   75 LGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLL-RTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGK 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408880 168 NEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGigdevtQLIpkTKIPAHTRYALQCRFSPDSTLLATCSAD 247
Cdd:COG2319  154 LLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG------KLL--RTLTGHTGAVRSVAFSPDGKLLASGSAD 225

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530408880 248 QTCKIWRTSNFSLMTELsiksgnpgESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAF 326
Cdd:COG2319  226 GTVRLWDLATGKLLRTL--------TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAF 296
WD40 COG2319
WD40 repeat [General function prediction only];
14-257 1.03e-39

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 144.28  E-value: 1.03e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408880  14 ILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAvqpvsLGYQHIRMYDLNSnnPNPIISYDGVNKN 93
Cdd:COG2319  176 LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASG-----SADGTVRLWDLAT--GKLLRTLTGHSGS 248

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408880  94 IASVGFHEDGRWMYTGGEDCTARIWDLRSRnlQCQRIFQV-NAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLI 172
Cdd:COG2319  249 VRSVAFSPDGRLLASGSADGTVRLWDLATG--ELLRTLTGhSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL 326

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408880 173 PEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIgdevtqliPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKI 252
Cdd:COG2319  327 TGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGE--------LLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRL 398


                 ....*
gi 530408880 253 WRTSN 257
Cdd:COG2319  399 WDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 15-254 1.07e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 135.93  E-value: 1.07e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408880  15 LATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAvqpvslGYQH-IRMYDLNSNNPnpIISYDGVNKN 93
Cdd:cd00200   66 LASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSS------SRDKtIKVWDVETGKC--LTTLRGHTDW 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408880  94 IASVGFHEDGRWMYTGGEDCTARIWDLRSrnLQCQRIFQV-NAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLI 172
Cdd:cd00200  138 VNSVAFSPDGTFVASSSQDGTIKLWDLRT--GKCVATLTGhTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTL 215

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408880 173 PEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGigdevtqlIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKI 252
Cdd:cd00200  216 RGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTG--------ECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRI 287


                 ..
gi 530408880 253 WR 254
Cdd:cd00200  288 WD 289
WD40 COG2319
WD40 repeat [General function prediction only];
98-327 8.84e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.45  E-value: 8.84e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408880  98 GFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVcLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEV 177
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLA-ASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408880 178 SITSAHIDPDASYMAAVNSTGNCYVWNLTGGIgdevtqliPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSN 257
Cdd:COG2319   80 AVLSVAFSPDGRLLASASADGTVRLWDLATGL--------LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT 151

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408880 258 FSLMTELSiksgnpgeSSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFN 327
Cdd:COG2319  152 GKLLRTLT--------GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS 213
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 178-329 1.02e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.17  E-value: 1.02e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408880 178 SITSAHIDPDASYMAAVNSTGNCYVWNLTGGIgdevtqliPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSN 257
Cdd:cd00200   11 GVTCVAFSPDGKLLATGSGDGTIKVWDLETGE--------LLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET 82

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530408880 258 FSLMTELsiksgnpgESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDS 329
Cdd:cd00200   83 GECVRTL--------TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD 146
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 222-329 3.91e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 91.24  E-value: 3.91e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408880 222 IPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGnpgessrgWMWGCAFSGDSQYIVTASSDNLAR 301
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTG--------PVRDVAASADGTYLASGSSDKTIR 76

                         90       100
                 ....*....|....*....|....*...
gi 530408880 302 LWCVETGEIKREYGGHQKAVVCLAFNDS 329
Cdd:cd00200   77 LWDLETGECVRTLTGHTSYVSSVAFSPD 104
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-162 1.31e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 90.09  E-value: 1.31e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408880   8 VGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAVqpvslGYQHIRMYDLNSnnPNPIISY 87
Cdd:cd00200  143 FSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSS-----SDGTIKLWDLST--GKCLGTL 215

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 530408880  88 DGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLqCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWD 162
Cdd:cd00200  216 RGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGEC-VQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 218-253 7.72e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 7.72e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 530408880   218 PKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIW 253
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
218-253 3.59e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 3.59e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 530408880  218 PKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIW 253
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
82-119 6.87e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 6.87e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 530408880   82 NPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWD 119
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 80-119 1.11e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 1.11e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 530408880    80 NPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWD 119
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 276-303 5.14e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.21  E-value: 5.14e-03
                           10        20
                   ....*....|....*....|....*...
gi 530408880   276 RGWMWGCAFSGDSQYIVTASSDNLARLW 303
Cdd:smart00320  12 TGPVTSVAFSPDGKYLASGSDDGTIKLW 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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