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Conserved domains on  [gi|530412634|ref|XP_005257618|]
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mitochondrial thiamine pyrophosphate carrier isoform X1 [Homo sapiens]

Protein Classification

solute carrier family 25 protein( domain architecture ID 13506698)

solute carrier 25 family (SLC25) protein which transfers molecules across the membranes of organelles, usually mitochondria

Gene Ontology:  GO:0016020|GO:1990542
TCDB:  2.A.29

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
Mito_carr pfam00153
Mitochondrial carrier protein;
118-203 2.41e-22

Mitochondrial carrier protein;


:

Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 89.25  E-value: 2.41e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412634  118 FSVHFVCGGLAACMATLTVHPVDVLRTRFAAQGEP--KVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSC 195
Cdd:pfam00153   5 FLASLLAGGIAGAIAVTVTYPLDVVKTRLQVQGGSgkSKGRGILDCFKKIYKEEGIRGLYKGLLPNLLRVAPAAAIYFGT 84

                  ....*...
gi 530412634  196 YSSLKHLY 203
Cdd:pfam00153  85 YETLKRLL 92
PTZ00169 super family cl36523
ADP/ATP transporter on adenylate translocase; Provisional
20-293 2.41e-22

ADP/ATP transporter on adenylate translocase; Provisional


The actual alignment was detected with superfamily member PTZ00169:

Pssm-ID: 240302 [Multi-domain]  Cd Length: 300  Bit Score: 94.83  E-value: 2.41e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412634  20 VAGSVSGLVTRALISPFDVIKIRFQLQHerlsrSDPSAK------YHGILQASRQILQEEGPTAFWKGHVPAQILSIGYG 93
Cdd:PTZ00169  12 LMGGISAAISKTAVAPIERVKMLIQTQD-----SIPEIKsgkvprYSGIVNCFRRVSKEQGVLSLWRGNTANVIRYFPTQ 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412634  94 AVQFLSFEMLTELVHRgsvYDARE-----FSVHFVCGGLAACMATLTVHPVDVLRTRFAA---QGEPKVYNTLRHAVGTM 165
Cdd:PTZ00169  87 AFNFAFKDYFKNMFPK---YNQKTdfwkfFGVNILSGGLAGASSLLIVYPLDFARTRLASdigKGGDREFTGLFDCLMKI 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412634 166 YRSEGPQVFYKGLAPTLIAIFPYAGLQFSCYSSLKH-----------LYKWAIPAEGKKNenlqnllcgsgAGVISktlt 234
Cdd:PTZ00169 164 SKQTGFLSLYQGFGVSVQGIIVYRGAYFGLYDSAKAllfgndkntniLYKWAVAQTVTIL-----------AGLIS---- 228
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 530412634 235 YPLDLFKKRLQVggfeHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAA 293
Cdd:PTZ00169 229 YPFDTVRRRMMM----MSGRKAKSEIQYTGTLDCWKKILKNEGLGGFFKGAWANVLRGA 283
 
Name Accession Description Interval E-value
Mito_carr pfam00153
Mitochondrial carrier protein;
118-203 2.41e-22

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 89.25  E-value: 2.41e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412634  118 FSVHFVCGGLAACMATLTVHPVDVLRTRFAAQGEP--KVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSC 195
Cdd:pfam00153   5 FLASLLAGGIAGAIAVTVTYPLDVVKTRLQVQGGSgkSKGRGILDCFKKIYKEEGIRGLYKGLLPNLLRVAPAAAIYFGT 84

                  ....*...
gi 530412634  196 YSSLKHLY 203
Cdd:pfam00153  85 YETLKRLL 92
PTZ00169 PTZ00169
ADP/ATP transporter on adenylate translocase; Provisional
20-293 2.41e-22

ADP/ATP transporter on adenylate translocase; Provisional


Pssm-ID: 240302 [Multi-domain]  Cd Length: 300  Bit Score: 94.83  E-value: 2.41e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412634  20 VAGSVSGLVTRALISPFDVIKIRFQLQHerlsrSDPSAK------YHGILQASRQILQEEGPTAFWKGHVPAQILSIGYG 93
Cdd:PTZ00169  12 LMGGISAAISKTAVAPIERVKMLIQTQD-----SIPEIKsgkvprYSGIVNCFRRVSKEQGVLSLWRGNTANVIRYFPTQ 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412634  94 AVQFLSFEMLTELVHRgsvYDARE-----FSVHFVCGGLAACMATLTVHPVDVLRTRFAA---QGEPKVYNTLRHAVGTM 165
Cdd:PTZ00169  87 AFNFAFKDYFKNMFPK---YNQKTdfwkfFGVNILSGGLAGASSLLIVYPLDFARTRLASdigKGGDREFTGLFDCLMKI 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412634 166 YRSEGPQVFYKGLAPTLIAIFPYAGLQFSCYSSLKH-----------LYKWAIPAEGKKNenlqnllcgsgAGVISktlt 234
Cdd:PTZ00169 164 SKQTGFLSLYQGFGVSVQGIIVYRGAYFGLYDSAKAllfgndkntniLYKWAVAQTVTIL-----------AGLIS---- 228
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 530412634 235 YPLDLFKKRLQVggfeHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAA 293
Cdd:PTZ00169 229 YPFDTVRRRMMM----MSGRKAKSEIQYTGTLDCWKKILKNEGLGGFFKGAWANVLRGA 283
Mito_carr pfam00153
Mitochondrial carrier protein;
216-306 1.80e-21

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 86.94  E-value: 1.80e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412634  216 NLQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGfEHARAafgqvrRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALS 295
Cdd:pfam00153   5 FLASLLAGGIAGAIAVTVTYPLDVVKTRLQVQG-GSGKS------KGRGILDCFKKIYKEEGIRGLYKGLLPNLLRVAPA 77
                          90
                  ....*....|.
gi 530412634  296 TGFMFFSYEFF 306
Cdd:pfam00153  78 AAIYFGTYETL 88
 
Name Accession Description Interval E-value
Mito_carr pfam00153
Mitochondrial carrier protein;
118-203 2.41e-22

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 89.25  E-value: 2.41e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412634  118 FSVHFVCGGLAACMATLTVHPVDVLRTRFAAQGEP--KVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSC 195
Cdd:pfam00153   5 FLASLLAGGIAGAIAVTVTYPLDVVKTRLQVQGGSgkSKGRGILDCFKKIYKEEGIRGLYKGLLPNLLRVAPAAAIYFGT 84

                  ....*...
gi 530412634  196 YSSLKHLY 203
Cdd:pfam00153  85 YETLKRLL 92
PTZ00169 PTZ00169
ADP/ATP transporter on adenylate translocase; Provisional
20-293 2.41e-22

ADP/ATP transporter on adenylate translocase; Provisional


Pssm-ID: 240302 [Multi-domain]  Cd Length: 300  Bit Score: 94.83  E-value: 2.41e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412634  20 VAGSVSGLVTRALISPFDVIKIRFQLQHerlsrSDPSAK------YHGILQASRQILQEEGPTAFWKGHVPAQILSIGYG 93
Cdd:PTZ00169  12 LMGGISAAISKTAVAPIERVKMLIQTQD-----SIPEIKsgkvprYSGIVNCFRRVSKEQGVLSLWRGNTANVIRYFPTQ 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412634  94 AVQFLSFEMLTELVHRgsvYDARE-----FSVHFVCGGLAACMATLTVHPVDVLRTRFAA---QGEPKVYNTLRHAVGTM 165
Cdd:PTZ00169  87 AFNFAFKDYFKNMFPK---YNQKTdfwkfFGVNILSGGLAGASSLLIVYPLDFARTRLASdigKGGDREFTGLFDCLMKI 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412634 166 YRSEGPQVFYKGLAPTLIAIFPYAGLQFSCYSSLKH-----------LYKWAIPAEGKKNenlqnllcgsgAGVISktlt 234
Cdd:PTZ00169 164 SKQTGFLSLYQGFGVSVQGIIVYRGAYFGLYDSAKAllfgndkntniLYKWAVAQTVTIL-----------AGLIS---- 228
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 530412634 235 YPLDLFKKRLQVggfeHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAA 293
Cdd:PTZ00169 229 YPFDTVRRRMMM----MSGRKAKSEIQYTGTLDCWKKILKNEGLGGFFKGAWANVLRGA 283
Mito_carr pfam00153
Mitochondrial carrier protein;
216-306 1.80e-21

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 86.94  E-value: 1.80e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412634  216 NLQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGfEHARAafgqvrRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALS 295
Cdd:pfam00153   5 FLASLLAGGIAGAIAVTVTYPLDVVKTRLQVQG-GSGKS------KGRGILDCFKKIYKEEGIRGLYKGLLPNLLRVAPA 77
                          90
                  ....*....|.
gi 530412634  296 TGFMFFSYEFF 306
Cdd:pfam00153  78 AAIYFGTYETL 88
Mito_carr pfam00153
Mitochondrial carrier protein;
16-111 7.60e-20

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 82.70  E-value: 7.60e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412634   16 FQVAVAGSVSGLVTRALISPFDVIKIRFQLQherlsRSDPSAKYHGILQASRQILQEEGPTAFWKGHVPAQILSIGYGAV 95
Cdd:pfam00153   6 LASLLAGGIAGAIAVTVTYPLDVVKTRLQVQ-----GGSGKSKGRGILDCFKKIYKEEGIRGLYKGLLPNLLRVAPAAAI 80
                          90
                  ....*....|....*.
gi 530412634   96 QFLSFEMLTELVHRGS 111
Cdd:pfam00153  81 YFGTYETLKRLLLKKL 96
PTZ00168 PTZ00168
mitochondrial carrier protein; Provisional
16-284 3.65e-11

mitochondrial carrier protein; Provisional


Pssm-ID: 185494 [Multi-domain]  Cd Length: 259  Bit Score: 62.25  E-value: 3.65e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412634  16 FQVAVAGSVSGLVTRALISPFDVIKIRFQLQHErLSRSDPSAKYHGILqasrqilqeegPTAFwkGHVPAqilSIGYGAV 95
Cdd:PTZ00168   4 FHNLVTGALSGVIVDAVLYPIDSIKTNIQAKKS-FSFSDIKKLYSGIL-----------PTLV--GTVPA---SAFFYCF 66
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412634  96 QFLSFEMLTElvHRGSVYDAREFSVHFVCGGLAACMATLtvhPVDVLRTRFAAQGEPKVYNTLRHavgTMYRSEGPQVFY 175
Cdd:PTZ00168  67 YELSKKLLTE--YRENISKTNLYLISTSIAEITACIVRL---PFEIVKQNMQVSGNISVLKTIYE---ITQREGLPSFLG 138
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412634 176 KGLAPTLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENLQNLLCGSGAGVISKTLTYPLDLFKKRlqvggfeharaa 255
Cdd:PTZ00168 139 KSYFVMIVREIPFDCIQYFLWETLKEKAKKDFGKFSKKYPSITSAICGGLAGGIAGFLTTPVDVIKSR------------ 206
                        250       260
                 ....*....|....*....|....*....
gi 530412634 256 fgQVRRYKGLMDCAKQVlQKEGALGFFKG 284
Cdd:PTZ00168 207 --QIIYGKSYIETVTEI-AEEGYLTFYKG 232
PTZ00169 PTZ00169
ADP/ATP transporter on adenylate translocase; Provisional
118-309 1.20e-04

ADP/ATP transporter on adenylate translocase; Provisional


Pssm-ID: 240302 [Multi-domain]  Cd Length: 300  Bit Score: 43.22  E-value: 1.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412634 118 FSVHFVCGGLAACMATLTVHPVDVLRTRFAAQ--------GEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYA 189
Cdd:PTZ00169   7 FATDFLMGGISAAISKTAVAPIERVKMLIQTQdsipeiksGKVPRYSGIVNCFRRVSKEQGVLSLWRGNTANVIRYFPTQ 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412634 190 GLQFScyssLKHLYKWAIPAEGKKNENLQ----NLLCGSGAGVISKTLTYPLDLFKKRL--QVGGfeharaafGQVRRYK 263
Cdd:PTZ00169  87 AFNFA----FKDYFKNMFPKYNQKTDFWKffgvNILSGGLAGASSLLIVYPLDFARTRLasDIGK--------GGDREFT 154
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 530412634 264 GLMDCakqvlqkegalgffkglspsLLKAALSTGFMFFSYEFFCNV 309
Cdd:PTZ00169 155 GLFDC--------------------LMKISKQTGFLSLYQGFGVSV 180
PTZ00169 PTZ00169
ADP/ATP transporter on adenylate translocase; Provisional
212-310 2.00e-04

ADP/ATP transporter on adenylate translocase; Provisional


Pssm-ID: 240302 [Multi-domain]  Cd Length: 300  Bit Score: 42.45  E-value: 2.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530412634 212 KKNENLQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGfEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLK 291
Cdd:PTZ00169   3 KKTNFATDFLMGGISAAISKTAVAPIERVKMLIQTQD-SIPEIKSGKVPRYSGIVNCFRRVSKEQGVLSLWRGNTANVIR 81
                         90
                 ....*....|....*....
gi 530412634 292 AALSTGFMFFSYEFFCNVF 310
Cdd:PTZ00169  82 YFPTQAFNFAFKDYFKNMF 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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